{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:14:15Z","timestamp":1792761255062,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s12602-018-9489-5","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T09:28:49Z","timestamp":1543310929000},"page":"910-920","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Assessing the Safety and Efficacy of Lactobacillus plantarum MTCC 5690 and Lactobacillus fermentum MTCC 5689 in Colitis Mouse Model"],"prefix":"10.1007","volume":"11","author":[{"given":"Diwas","family":"Pradhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"H.M.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender K.","family":"Batish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Grover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"issue":"1","key":"9489_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jped.2014.08.005","volume":"91","author":"Y Vandenplas","year":"2015","unstructured":"Vandenplas Y, Huys G, Daube G (2015) Probiotics: an update. J Pediatr (Rio J) 91(1):6\u201321","journal-title":"J Pediatr (Rio J)"},{"issue":"2","key":"9489_CR2","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.tifs.2007.07.013","volume":"19","author":"V Vankerckhoven","year":"2008","unstructured":"Vankerckhoven V, Huys G, Vancanneyt M, Vael C, Klare I, Romond MB, Entenza JM, Moreillon P, Wind RD, Knol J, Wiertz E (2008) Biosafety assessment of probiotics used for human consumption: recommendations from the EU-PROSAFE project. Trends Food Sci Technol 19(2):102\u2013114","journal-title":"Trends Food Sci Technol"},{"issue":"4","key":"9489_CR3","first-page":"283","volume":"42","author":"A Avlami","year":"2001","unstructured":"Avlami A, Kordossis T, Vrizidis N, Sipsas NV (2001) Lactobacillus rhamnosus endocarditis complicating colonoscopy. J Inf Secur 42(4):283\u2013285","journal-title":"J Inf Secur"},{"issue":"5","key":"9489_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/01.smj.0000257630.31898.6f","volume":"100","author":"V Chanet","year":"2007","unstructured":"Chanet V, Brazille P, Honore S, Michel M, Schaeffer A, Zarrouk V (2007) Lactobacillus septic arthritis. South Med J 100(5):531\u2013532","journal-title":"South Med J"},{"key":"9489_CR5","volume-title":"Guidelines for the evaluation of probiotics in food Report of a Joint FAO\/WHO Working Group on Drafting Guidelines for the evaluation of probiotics in food","author":"FAO\/WHO","year":"2002","unstructured":"FAO\/WHO (2002) Guidelines for the evaluation of probiotics in food Report of a Joint FAO\/WHO Working Group on Drafting Guidelines for the evaluation of probiotics in food. World Health Organization, London"},{"issue":"1","key":"9489_CR6","first-page":"22","volume":"134","author":"NK Ganguly","year":"2011","unstructured":"Ganguly NK, Bhattacharya SK, Sesikeran B, Nair GB, Ramakrishna BS, Sachdev HPS, Batish VK, Kanagasabapathy AS, Muthuswamy V, Kathuria SC, Katoch VM (2011) ICMR-DBT guidelines for evaluation of probiotics in food. Indian J Med Res 134(1):22\u201325","journal-title":"Indian J Med Res"},{"issue":"3","key":"9489_CR7","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4161\/gmic.1.3.12127","volume":"1","author":"ME Sanders","year":"2010","unstructured":"Sanders ME, Akkermans LMA, Haller D, Hammerman C, Heimbach JT, H\u00f6rmannsperger G, Huys G (2010) Safety assessment of probiotics for human use. Gut Microbes 1(3):164\u2013185","journal-title":"Gut Microbes"},{"issue":"5\u20136","key":"9489_CR8","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.foodres.2009.02.004","volume":"42","author":"R Frias","year":"2009","unstructured":"Frias R, Ouwehand A, Spillmann T, Vankerckhoven V, Hewicker-Trautwein M, Salminen S, Gueimonde M (2009) Effect of clinical and probiotic Lactobacillus rhamnosus strains on intestinal permeability and bacterial translocation in healthy and colitic rats. Food Res Int 42(5\u20136):636\u2013640","journal-title":"Food Res Int"},{"issue":"4","key":"9489_CR9","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1128\/CDLI.10.4.696-701.2003","volume":"10","author":"S Pavan","year":"2003","unstructured":"Pavan S, Desreumaux P, Mercenier A (2003) Use of mouse models to evaluate the persistence, safety, and immune modulation capacities of lactic acid bacteria. Clin Diagn Lab Immunol 10(4):696\u2013701","journal-title":"Clin Diagn Lab Immunol"},{"issue":"9","key":"9489_CR10","doi-asserted-by":"publisher","first-page":"5799","DOI":"10.1128\/AEM.00109-06","volume":"72","author":"C Daniel","year":"2006","unstructured":"Daniel C, Poiret S, Goudercourt D, Dennin V, Leyer G, Pot B (2006) Selecting lactic acid bacteria for their safety and functionality by use of a mouse colitis model. Appl Environ Microbiol 72(9):5799\u20135805","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"9489_CR11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ijfoodmicro.2004.11.032","volume":"103","author":"MV Herias","year":"2005","unstructured":"Herias MV, Koninkx JFJG, Vos JG, In't Veld JH, Van Dijk JE (2005) Probiotic effects of Lactobacillus casei on DSS-induced ulcerative colitis in mice. Int J Food Microbiol 103(2):143\u2013155","journal-title":"Int J Food Microbiol"},{"issue":"9","key":"9489_CR12","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.micres.2013.04.010","volume":"168","author":"A Chandran","year":"2013","unstructured":"Chandran A, Duary RK, Grover S, Batish VK (2013) Relative expression of bacterial and host specific genes associated with probiotic survival and viability in the mice gut fed with Lactobacillus plantarum Lp91. Microbiol Res 168(9):555\u2013562","journal-title":"Microbiol Res"},{"issue":"5","key":"9489_CR13","doi-asserted-by":"publisher","first-page":"664","DOI":"10.4103\/0971-5916.90992","volume":"134","author":"RK Duary","year":"2011","unstructured":"Duary RK, Rajput YS, Batish VK, Grover S (2011) Assessing the adhesion of putative indigenous probiotic lactobacilli to human colonic epithelial cells. Indian J Med Res 134(5):664\u2013671","journal-title":"Indian J Med Res"},{"issue":"8","key":"9489_CR14","doi-asserted-by":"publisher","first-page":"7887","DOI":"10.1007\/s11033-012-1633-9","volume":"39","author":"AA Achuthan","year":"2012","unstructured":"Achuthan AA, Duary RK, Madathil A, Panwar H, Kumar H, Batish VK, Grover S (2012) Antioxidative potential of lactobacilli isolated from the gut of Indian people. Mol Biol Rep 39(8):7887\u20137897","journal-title":"Mol Biol Rep"},{"key":"9489_CR15","volume":"2014","author":"R Chauhan","year":"2014","unstructured":"Chauhan R, Sudhakaran VA, Panwar H, Mallapa RH, Duary RK, Batish VK, Grover S (2014) Amelioration of colitis in mouse model by exploring antioxidative potentials of an indigenous probiotic strain of Lactobacillus fermentum Lf1. Biomed Res Int 2014:206732","journal-title":"Biomed Res Int"},{"issue":"4","key":"9489_CR16","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.1007\/s11033-011-1269-1","volume":"39","author":"R Duary","year":"2012","unstructured":"Duary R, Bhausaheb M, Batish V, Grover S (2012) Anti-inflammatory and immunomodulatory efficacy of indigenous probiotic Lactobacillus plantarum Lp91 in colitis mouse model. Mol Biol Rep 39(4):4765\u20134775","journal-title":"Mol Biol Rep"},{"key":"9489_CR17","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1017\/S0007114510003740","volume":"105","author":"R Kumar","year":"2011","unstructured":"Kumar R, Grover S, Batish VK (2011) Hypocholesterolaemic effect of dietary inclusion of two putative probiotic bile salt hydrolase-producing Lactobacillus plantarum strains in Sprague\u2013Dawley rats. Br J Nutr 105:561\u2013573","journal-title":"Br J Nutr"},{"issue":"12","key":"9489_CR18","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1099\/jmm.0.000366","volume":"65","author":"N Rokana","year":"2016","unstructured":"Rokana N, Singh R, Mallappa RH, Batish VK, Grover S (2016) Modulation of intestinal barrier function to ameliorate Salmonella infection in mice by oral administration of fermented milks produced with Lactobacillus plantarum MTCC 5690\u2013a probiotic strain of Indian gut origin. J Med Microbiol 65(12):1482\u20131493","journal-title":"J Med Microbiol"},{"key":"9489_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yrtph.2018.10.011","volume":"101","author":"D Pradhan","year":"2019","unstructured":"Pradhan D, Singh R, Tyagi A, Rashmi HM, Batish VK, Grover S (2019) Assessing safety of Lactobacillus plantarum MTCC 5690 and Lactobacillus fermentum MTCC 5689 using in vitro approaches and an in vivo murine model. Regul Toxicol Pharmacol 101:1\u201311","journal-title":"Regul Toxicol Pharmacol"},{"issue":"12","key":"9489_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008099","volume":"4","author":"JK Kaushik","year":"2009","unstructured":"Kaushik JK, Kumar A, Duary RK, Mohanty AK, Grover S, Batish VK (2009) Functional and probiotic attributes of an indigenous isolate of Lactobacillus plantarum. PLoS One 4(12):e8099","journal-title":"PLoS One"},{"issue":"3","key":"9489_CR21","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1099\/jmm.0.45770-0","volume":"54","author":"EM Dickson","year":"2005","unstructured":"Dickson EM, Riggio MP, Macpherson L (2005) A novel species-specific PCR assay for identifying Lactobacillus fermentum. J Med Microbiol 54(3):299\u2013303","journal-title":"J Med Microbiol"},{"issue":"2","key":"9489_CR22","first-page":"238","volume":"69","author":"HS Cooper","year":"1993","unstructured":"Cooper HS, Murthy SN, Shah RS, Sedergran DJ (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Investig 69(2):238\u2013249","journal-title":"Lab Investig"},{"issue":"5","key":"9489_CR23","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.3945\/ajcn.2009.28095","volume":"90","author":"PD Cani","year":"2009","unstructured":"Cani PD, Lecourt E, Dewulf EM, Sohet FM, Pachikian BD, Naslain D, De Backer F, Neyrinck AM, Delzenne NM (2009) Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr 90(5):1236\u20131243","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"9489_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12876-014-0189-7","volume":"14","author":"SC Bischoff","year":"2014","unstructured":"Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM (2014) Intestinal permeability\u2013a new target for disease prevention and therapy. BMC Gastroenterol 14(1):189","journal-title":"BMC Gastroenterol"},{"key":"9489_CR25","doi-asserted-by":"publisher","first-page":"628157","DOI":"10.1155\/2015\/628157","volume":"2015","author":"A Michielan","year":"2015","unstructured":"Michielan A, D\u2019Inc\u00e0 R (2015) Intestinal permeability in inflammatory bowel disease: pathogenesis, clinical evaluation, and therapy of leaky gut. Mediat Inflamm 2015:628157","journal-title":"Mediat Inflamm"},{"issue":"6","key":"9489_CR26","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.4014\/jmb.1512.12002","volume":"26","author":"SH Kim","year":"2016","unstructured":"Kim SH, Jeung W, Choi ID, Jeong JW, LDE HCS, Kim GB, Hong SS, Shim JJ, Lee JL (2016) Lactic acid bacteria improves Peyer\u2019s patch cell-mediated immunoglobulin A and tight-junction expression in a destructed gut microbial environment. J Microbiol Biotechnol 26(6):1035\u20131045","journal-title":"J Microbiol Biotechnol"},{"key":"9489_CR27","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.lwt.2016.08.021","volume":"84","author":"N Rokana","year":"2017","unstructured":"Rokana N, Mallappa RH, Batish VK, Grover S (2017) Interaction between putative probiotic Lactobacillus strains of Indian gut origin and Salmonella: impact on intestinal barrier function. LWT-Food Sci Technol 84:851\u2013860","journal-title":"LWT-Food Sci Technol"},{"issue":"7","key":"9489_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134050","volume":"10","author":"D Srutkova","year":"2015","unstructured":"Srutkova D, Schwarzer M, Hudcovic T, Zakostelska Z, Drab V, Spanova A, Rittich B, Kozakova H, Schabussova I (2015) Bifidobacterium longum CCM 7952 promotes epithelial barrier function and prevents acute DSS-induced colitis in strictly strain-specific manner. PLoS One 10(7):e0134050","journal-title":"PLoS One"},{"issue":"4","key":"9489_CR29","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1002\/jsfa.6467","volume":"94","author":"M Bosch","year":"2014","unstructured":"Bosch M, Fuentes MC, Audivert S, Bonachera MA, Peir\u00f3 S, Cu\u00f1\u00e9 J (2014) Lactobacillus plantarum CECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels. J Sci Food Agric 94(4):803\u2013809","journal-title":"J Sci Food Agric"},{"issue":"3","key":"9489_CR30","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/liv.12566","volume":"35","author":"E Sanchez","year":"2015","unstructured":"Sanchez E, Nieto JC, Boullosa A, Vidal S, Sancho FJ, Rossi G, Sancho-Bru P, Oms R, Mirelis B, Ju\u00e1rez C, Guarner C (2015) VSL# 3 probiotic treatment decreases bacterial translocation in rats with carbon tetrachloride-induced cirrhosis. Liver Int 35(3):735\u2013745","journal-title":"Liver Int"},{"issue":"2\u20133","key":"9489_CR31","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0278-6915(99)00154-4","volume":"38","author":"JS Zhou","year":"2000","unstructured":"Zhou JS, Shu Q, Rutherfurd KJ, Prasad J, Gopal PK, Gill HS (2000) Acute oral toxicity and bacterial translocation studies on potentially probiotic strains of lactic acid bacteria. Food Chem Toxicol 38(2\u20133):153\u2013161","journal-title":"Food Chem Toxicol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-018-9489-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12602-018-9489-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-018-9489-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T02:18:39Z","timestamp":1605493119000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12602-018-9489-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["9489"],"URL":"https:\/\/doi.org\/10.1007\/s12602-018-9489-5","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"assertion":[{"value":"27 November 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal studies were conducted as per current legislation on animal experiments with approval from the Institutional Animal Ethical Committee (IAEC approval no. 76\/14) of Indian Council of Agricultural Research-National Dairy Research Institute, Deemed University, Karnal-132001, Haryana, India (Reg. No. 1705\/GO\/ac\/13\/CPCSA\/2013).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}