{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:05:16Z","timestamp":1787616316386,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Project Global Initiatives for Preliferation Prevention","award":["T2- 298, ISTC A-1866P"],"award-info":[{"award-number":["T2- 298, ISTC A-1866P"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s12602-019-09569-y","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T15:03:09Z","timestamp":1563894189000},"page":"716-724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Characteristic of Bacteriocins of Lactobacillus rhamnosus BTK 20-12 Potential Probiotic Strain"],"prefix":"10.1007","volume":"12","author":[{"given":"Flora N.","family":"Tkhruni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armen E.","family":"Aghajanyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsovinar R.","family":"Balabekyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana V.","family":"Khachatryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina J.","family":"Karapetyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"9569_CR1","volume-title":"Indigenous fermented foods of South Asia. Fermented foods and beverages series","author":"VK Joshi","year":"2015","unstructured":"Joshi VK (2015) Indigenous fermented foods of South Asia. Fermented foods and beverages series. CRC, Boca Raton ISBN 9781439887837 - CAT# K14059"},{"key":"9569_CR2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.fshw.2015.06.002","volume":"4","author":"EB-M Daliri","year":"2015","unstructured":"Daliri EB-M, Lee BH (2015) New perspectives on probiotics in health and disease. Food Sci Hum Wellness 4:56\u201365","journal-title":"Food Sci Hum Wellness"},{"issue":"7","key":"9569_CR3","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1128\/AEM.04272-13","volume":"80","author":"R Hertzberger","year":"2014","unstructured":"Hertzberger R, Arents J, Dekker HL, Pridmore RD, Gysler C, Kleerebezem M, de Mattos MJT (2014) H2O2 production in species of the Lactobacillus acidophilus group: a central role for a novel NADH-dependent flavin reductase. Appl Environ Microbiol 80(7):2229\u20132239. \nhttps:\/\/doi.org\/10.1128\/AEM.04272-13","journal-title":"Appl Environ Microbiol"},{"issue":"20399","key":"9569_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3402\/mehd.v24i0.20399","volume":"24","author":"BA Shenderov","year":"2013","unstructured":"Shenderov BA (2013) Metabiotics: novel idea or natural development of probiotic conception. Microb Ecol Health Dis 24(20399):1. \nhttps:\/\/doi.org\/10.3402\/mehd.v24i0.20399","journal-title":"Microb Ecol Health Dis"},{"issue":"4","key":"9569_CR5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00253-008-1726-5","volume":"81","author":"O Gillor","year":"2008","unstructured":"Gillor O, Etzion A, Riley MA (2008) The dual role of bacteriocins as anti- and probiotics. Appl Microbiol Biotechnol 81(4):591\u2013606","journal-title":"Appl Microbiol Biotechnol"},{"issue":"6","key":"9569_CR6","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1111\/j.1365-2672.2009.04539.x","volume":"107","author":"R Dimitrijevi\u0107","year":"2009","unstructured":"Dimitrijevi\u0107 R, Stojanovi\u0107 M, Zivkovi\u0107 I, Petersen A, Jankov RM, Dimitrijevi\u0107 L, Gavrovi\u0107-Jankulovi\u0107 M (2009) The identification of a low molecular mass bacteriocin rhamnosin A, produced by Lactobacillus rhamnosus strain 68. J Appl Microbiol 107(6):2108\u20132115","journal-title":"J Appl Microbiol"},{"issue":"2","key":"9569_CR7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/jac\/dkl246","volume":"58","author":"M Falagas","year":"2006","unstructured":"Falagas M, Betsi G, Athanasiou S (2006) Probiotics for prevention of recurrent vulvovaginal candidiasis: a review. J Antimicrob Chemother 58(2):266\u2013272","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"9569_CR8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0928-8244(02)00465-0","volume":"35","author":"G Reid","year":"2003","unstructured":"Reid G, Charbonneau D, Erb J, Kochanowski B, Beuerman D, Poehner R, Bruce AW (2003) Oral use of Lactobacillus rhamnosus GR-1 and L.fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol 35(2):131\u2013134","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"10","key":"9569_CR9","first-page":"771","volume":"43","author":"SJ Weese","year":"2002","unstructured":"Weese SJ, Anderson ME (2002) Preliminary evaluation of Lactobacillus rhamnosus strain GG, a potential probiotic in dogs. Can Vet J 43(10):771\u2013774","journal-title":"Can Vet J"},{"issue":"12","key":"9569_CR10","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/nmo.12232","volume":"25","author":"F Ammoscato","year":"2013","unstructured":"Ammoscato F, Scirocco A, Altomare A, Matarrese P, Petitta C, Ascione B, Caronna R, Guarino M, Marignani M, Cicala M, Chirletti P, Malorni W, Severi C (2013) Lactobacillus rhamnosus protects human colonic muscle from pathogen lipopolysaccharide-induced damage. Neurogastroenterol Motil 25(12):984\u2013e777","journal-title":"Neurogastroenterol Motil"},{"issue":"6","key":"9569_CR11","first-page":"2462","volume":"2","author":"BR Aguilar-Uscanga","year":"2013","unstructured":"Aguilar-Uscanga BR, Sol\u00eds-Pacheco JR, Plascencia L, Aguilar-Uscanga MG, Garc\u00eda HS, Lacroix M (2013) Effect of culture medium on bacteriocin production by Lactobacillus rhamnosus HN001 and Lactobacillus reuteri ATCC 53608. J Microbiol Biotechnol Food Sci 2(6):2462\u20132468","journal-title":"J Microbiol Biotechnol Food Sci"},{"issue":"4","key":"9569_CR12","first-page":"283","volume":"55","author":"SD Todorov","year":"2005","unstructured":"Todorov SD, Dicks LMT (2005) Growth parameters influencing the production of Lactobacillus rhamnosus bacteriocins ST461BZ and ST462BZ. Ann Microbiol 55(4):283\u2013289","journal-title":"Ann Microbiol"},{"key":"9569_CR13","unstructured":"World Health Organization (WHO) (2012) World health statistics. [Electronic Book] France: WHO Press; [cited 17 July 2012]; Available from: \nhttp:\/\/www.who.int\/healthinfo\/EN_WHS.Full.pdf"},{"issue":"6","key":"9569_CR14","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1128\/AAC.01736-10","volume":"55","author":"MM D\u2019Andrea","year":"2011","unstructured":"D\u2019Andrea MM, Literacka E, Zioga A, Giani T, Baraniak A, Fiett J, Sadowy E, Tassios PT, Rossolini GM, Gniadkowski M, Miriagou V (2011) Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe. Antimicrob Agents Chemother 55(6):2735\u20132742","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"9569_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/jmbe.v18i2.1348","volume":"18","author":"MH Wright","year":"2017","unstructured":"Wright MH, Adelskov J, Greene AC (2017) Bacterial DNA extraction using individual enzymes and phenol\/chloroform separation. J Microbiol Biol Educ 18(2):1\u20133","journal-title":"J Microbiol Biol Educ"},{"issue":"1","key":"9569_CR16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0167-7012(01)00213-5","volume":"45","author":"H B\u00fcrgmann","year":"2001","unstructured":"B\u00fcrgmann H, Pesaro M, Widmer F, Zeyer J (2001) A strategy for optimizing quality and quantity of DNA extracted from soil. J Microbiol Methods 45(1):7\u201320","journal-title":"J Microbiol Methods"},{"issue":"3","key":"9569_CR17","first-page":"97","volume":"45","author":"A Pavlicek","year":"1999","unstructured":"Pavlicek A et al (1999) Fre-tree-freeware program for construction of phylogenetic trees on the basis of distance data and bootstrap\\jackknife analysis of tree robustness. Application in the RAPD analysis of genus Frenkelia. Folia Biol (Praha) 45(3):97\u201399","journal-title":"Folia Biol (Praha)"},{"key":"9569_CR18","first-page":"32","volume":"3","author":"AE Aghajanyan","year":"2015","unstructured":"Aghajanyan AE, Tkhruni FN, Hovhannisyan GZ, Yeghiyan KI, Vardanyan AA, Saghyan AS (2015) Isolation and purification of bioinhibitory product from culture liquid of lactic acid bacteria Lactobacillus acidophilus 1991 VKPM 6257 and Lactobacillus rhamnosus INMIA 9614. J Biotechnol 3:32\u201340","journal-title":"J Biotechnol"},{"issue":"18","key":"9569_CR19","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.5897\/AJMR11.225","volume":"5","author":"M Aslam","year":"2011","unstructured":"Aslam M, Shahid M, Rehman FU, Naveed NH, Batool AI, Sharif S, Asia A (2011) Purification and characterization of bacteriocin, isolated from Streptococcus thermophilus. Afr J Microbiol Res 5(18):2642\u20132648","journal-title":"Afr J Microbiol Res"},{"issue":"1","key":"9569_CR20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0167-7012(94)00068-I","volume":"22","author":"E Parente","year":"1995","unstructured":"Parente E, Brienza C, Moles M, Ricciardi A (1995) A comparison of methods for the measurement of bacteriocin activity. J Microbiol Methods 22(1):95\u2013108","journal-title":"J Microbiol Methods"},{"issue":"3","key":"9569_CR21","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s11274-011-0895-z","volume":"28","author":"SD Todorov","year":"2012","unstructured":"Todorov SD, Leblanc JG, Franco BD (2012) Evaluation of the probiotic potential and effect of encapsulation on survival for Lactobacillus plantarum ST16Pa isolated from papaya. World J Microbiol Biotechnol 28(3):973\u2013984","journal-title":"World J Microbiol Biotechnol"},{"key":"9569_CR22","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3389\/fmicb.2017.00846","volume":"8","author":"DM Linares","year":"2017","unstructured":"Linares DM, G\u00f3mez C, Renes E, Fresno JM, Tornadijo ME, Ross RP, Stanton C (2017) Lactic acid bacteria and bifidobacteria with potential to design natural biofunctional health-promoting dairy foods. Front Microbiol 8:846. \nhttps:\/\/doi.org\/10.3389\/fmicb.2017.00846","journal-title":"Front Microbiol"},{"issue":"2","key":"9569_CR23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1128\/AEM.57.2.499-502.1991","volume":"57","author":"A Henriksson","year":"1991","unstructured":"Henriksson A, Szewzyk R, Conway P (1991) Characteristics of the adhesive determinants of Lactobacillus fermentum 104. Appl Environ Microbiol 57(2):499\u2013502","journal-title":"Appl Environ Microbiol"},{"issue":"4","key":"9569_CR24","doi-asserted-by":"crossref","first-page":"399","DOI":"10.18097\/pbmc20135904399","volume":"59","author":"TV Sirota","year":"2013","unstructured":"Sirota TV (2013) Use of nitro blue tetrazolium in the reaction of adrenaline autooxidation for the determination of superoxide dismutase activity. Biomed Khim 59(4):399\u2013410 (Article in Russian)","journal-title":"Biomed Khim"},{"issue":"5","key":"9569_CR25","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00217-008-0870-6","volume":"227","author":"P Fernandes","year":"2008","unstructured":"Fernandes P, Lopez P, Corbi A, Pelaez C, Requena T (2008) Probiotic strains: survival under simulated gastrointestinal conditions, in vitro adhesion to Caco-2 cells and effect of cytokine secretion. Eur Food Res Technol 227(5):1475\u20131484","journal-title":"Eur Food Res Technol"},{"key":"9569_CR26","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fmicb.2013.00202","volume":"4","author":"M Gueimonde","year":"2013","unstructured":"Gueimonde M, S\u00e1nchez B, de los Reyes-Gavil\u00e1n CG, Margolles A (2013) Antibiotic resistance in probiotic bacteria. Front Microbiol 4:202. \nhttps:\/\/doi.org\/10.3389\/fmicb.2013.00202","journal-title":"Front Microbiol"},{"issue":"1","key":"9569_CR27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1128\/AEM.57.1.114-121.1991","volume":"57","author":"TR Klaenhammer","year":"1991","unstructured":"Klaenhammer TR, Muriana PM (1991) Purification and partial characterization of lactacin F, a bacteriocin produced by Lactobacillus acidophilus 11088. Appl Environ Microbiol 57(1):114\u2013121","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"9569_CR28","first-page":"291","volume":"2","author":"AR Sarika","year":"2010","unstructured":"Sarika AR, Lipton AP, Aishwarya MS (2010) Bacteriocin production by a new isolate of Lactobacillus rhamnosus GP1 under different culture conditions. Adv J Food Sci Technol 2(5):291\u2013297","journal-title":"Adv J Food Sci Technol"},{"key":"9569_CR29","first-page":"1","volume":"3","author":"FN Tkhruni","year":"2016","unstructured":"Tkhruni FN (2016) Efficiency of metabiotics from lactic acid bacteria against pathogens. Int J Curr Res Acad Rev 3:1\u201311","journal-title":"Int J Curr Res Acad Rev"},{"key":"9569_CR30","first-page":"61","volume":"3","author":"A Israyelyan","year":"2015","unstructured":"Israyelyan A, Karapetyan K, Tkhruni F, Arstamyan L, Balabekyan T (2015) Sensitivity of different pathogens to biological antimicrobial agents. Eur J Biol Life Sci 3:61\u201366","journal-title":"Eur J Biol Life Sci"},{"issue":"7","key":"9569_CR31","first-page":"357","volume":"6","author":"K Karapetyan","year":"2017","unstructured":"Karapetyan K, Tkhruni F, Israyelyan A, Yermolenko E, Verdyan A (2017) Comparative characterization of endemic lactic acid bacteria of Enterococcus Genus. Int J Sci Technol Res 6(7):357\u2013361","journal-title":"Int J Sci Technol Res"},{"key":"9569_CR32","unstructured":"Tkhruni FN, Saghyan AS, Balabekyan TsR, Karapetyan KJ, Khachatryan TV, Aghajanyan AE (2015) Lactobacillus rhamnosus B\u0422\u041a 20-12 bacteria strain, producing Rhamn 20-12 BCN1 and Rhamn 20-12 BCN2 bacteriocins RA Patent: \u2116 2924 \u0410. Available at https:\/\/armpat@aipa.am"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-019-09569-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12602-019-09569-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-019-09569-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T23:26:45Z","timestamp":1595374005000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12602-019-09569-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["9569"],"URL":"https:\/\/doi.org\/10.1007\/s12602-019-09569-y","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"assertion":[{"value":"23 July 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}