{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:46:18Z","timestamp":1794491178218,"version":"4.9.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003194","name":"Agent\u00fara Ministerstva \u0160kolstva, Vedy, V\u00fdskumu a \u0160portu SR","doi-asserted-by":"publisher","award":["VEGA 1\/0505\/19"],"award-info":[{"award-number":["VEGA 1\/0505\/19"]}],"id":[{"id":"10.13039\/501100003194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12602-019-09626-6","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T23:02:14Z","timestamp":1578438134000},"page":"929-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Effect of Application of Probiotic Pollen Suspension on Immune Response and Gut Microbiota of Honey Bees (Apis mellifera)"],"prefix":"10.1007","volume":"12","author":[{"given":"Ivana Cinge\u013eov\u00e1","family":"Maru\u0161\u010d\u00e1kov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Schusterov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohumil","family":"Bielik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Topor\u010d\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katar\u00edna","family":"B\u00edlikov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8007-6237","authenticated-orcid":false,"given":"Dagmar","family":"Mudro\u0148ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"9626_CR1","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s13592-016-0440-z","volume":"47","author":"MP Chauzat","year":"2016","unstructured":"EPILOBEE Consortium, Chauzat MP, Jacques A, Laurent M, Bougeard S, Hendrikx P, Ribi\u00e8re-Chabert M (2016) Risk indicators affecting honey bee colony survival in Europe: one year of surveillance. Apidologie 47:348\u2013378. https:\/\/doi.org\/10.1007\/s13592-016-0440-z","journal-title":"Apidologie"},{"issue":"3","key":"9626_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0172591","volume":"12","author":"A Jacques","year":"2017","unstructured":"Jacques A, Laurent M, Epilobee Consortium (Topor\u010d\u00e1k J et al.), Ribi\u00e8re-Chabert M, Saussac M, Bougeard S, Budge GE, Hendrikx P, Chauzat MP (2017) A pan-European epidemiological study reveals honey bee colony survival depends on beekeeper education and disease control. PLoS One 12(3):1\u201317. https:\/\/doi.org\/10.1371\/journal.pone.0172591","journal-title":"PLoS One"},{"key":"9626_CR3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jip.2010.08.004","volume":"105","author":"N Bacandritsos","year":"2010","unstructured":"Bacandritsos N, Granato A, Budge G, Papanastasiou I, Roinioti E, Caldon M, Falcaro C, Gallina A, Mutinelli F (2010) Sudden deaths and colony population decline in Greek honey bee colonies. J Invertebr Pathol 105:335\u2013340. https:\/\/doi.org\/10.1016\/j.jip.2010.08.004","journal-title":"J Invertebr Pathol"},{"issue":"4","key":"9626_CR4","first-page":"127","volume":"55","author":"D Mudro\u0148ov\u00e1","year":"2011","unstructured":"Mudro\u0148ov\u00e1 D, Rumanovsk\u00e1 K, Topor\u010d\u00e1k J, Nemcov\u00e1 R, Gancar\u010d\u00edkov\u00e1 S, Hajdu\u010dkov\u00e1 V (2011) Selection of probiotic lactobacilli designed for the prevention of American foulbrood. Folia Vet 55(4):127\u2013132","journal-title":"Folia Vet"},{"issue":"3","key":"9626_CR5","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3920\/BM2016.0114","volume":"8","author":"V Karaffov\u00e1","year":"2017","unstructured":"Karaffov\u00e1 V, Csank T, Mudro\u0148ov\u00e1 D, Kir\u00e1ly J, Revajov\u00e1 V, Gancar\u010d\u00edkov\u00e1 S, Nemcov\u00e1 R, Pistl J, Vil\u010dek \u0160, Levkut M (2017) Influence of Lactobacillus reuteri L26 Biocenol\u2122 on immune response against porcine circovirus type 2 infection in germ-free mice. Benefic Microbes 8(3):367\u2013378. https:\/\/doi.org\/10.3920\/BM2016.0114","journal-title":"Benefic Microbes"},{"issue":"2","key":"9626_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3920\/BM2017.0075","volume":"9","author":"D Arredondo","year":"2018","unstructured":"Arredondo D, Castelli L, Porrini MP, Garrido PM, Eguaras MJ, Zunino P, Ant\u00fanez K (2018) Lactobacillus kunkeei strains decreased the infection by honey bee pathogens Paenibacillus larvae and Nosema ceranae. Benefic Microbes 9(2):279\u2013290. https:\/\/doi.org\/10.3920\/BM2017.0075","journal-title":"Benefic Microbes"},{"key":"9626_CR7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.11178\/jdsa.8.85","volume":"8","author":"M Wu","year":"2013","unstructured":"Wu M, Sugimura Y, Taylor D, Yoshiyama M (2013) Honey bee gastrointestinal bacteria for novel and sustainable diesease control strategies. J Develop Sustain Agr 8:85\u201390. https:\/\/doi.org\/10.11178\/jdsa.8.85","journal-title":"J Develop Sustain Agr"},{"issue":"37","key":"9626_CR8","doi-asserted-by":"publisher","first-page":"5941","DOI":"10.3748\/wjg.v12.i37.5941","volume":"12","author":"JB Ewaschuk","year":"2006","unstructured":"Ewaschuk JB, Dieleman LA (2006) Probiotics and prebiotics in chronic inflammatory bowel diseases. World J Gastroenterol 12(37):5941\u20135950. https:\/\/doi.org\/10.3748\/wjg.v12.i37.5941","journal-title":"World J Gastroenterol"},{"key":"9626_CR9","volume-title":"Imunitn\u00ed system v\u010del. Univerzita veterin\u00e1rskeho lek\u00e1rstva a farm\u00e1cie v Ko\u0161iciach","author":"J Bzdil","year":"2016","unstructured":"Bzdil J, Topor\u010d\u00e1k J, Bil\u00edkov\u00e1 K (2016) Imunitn\u00ed system v\u010del. Univerzita veterin\u00e1rskeho lek\u00e1rstva a farm\u00e1cie v Ko\u0161iciach. Ko\u0161ice, Slovakia"},{"key":"9626_CR10","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jip.2009.06.019","volume":"103","author":"JD Evans","year":"2010","unstructured":"Evans JD, Spivak M (2010) Socialized medicine: individual and communal disease barriers in honey bees. J Invertebr Pathol 103:62\u201372. https:\/\/doi.org\/10.1016\/j.jip.2009.06.019","journal-title":"J Invertebr Pathol"},{"key":"9626_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.cyto.2017.06.007","volume":"97","author":"D Luongo","year":"2017","unstructured":"Luongo D, Treppiccione L, Sorrentino A, Ferrocino I, Turroni S, Gatti M, Di Cagno R, Sanz Y, Ross M (2017) Immune-modulating effects in mouse dendritic cells of lactobacilli and bifidobacteria isolated from individuals following omnivorous, vegetarian and vegan diets. Cytokine 97:141\u2013148. https:\/\/doi.org\/10.1016\/j.cyto.2017.06.007","journal-title":"Cytokine"},{"key":"9626_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cois.2015.04.016","volume":"10","author":"LM Brutscher","year":"2015","unstructured":"Brutscher LM, Daughenbaugh KF, Flenniken ML (2015) Antiviral defense mechanisms in honey bees. Curr Opin Insect Sci 10:71\u201382. https:\/\/doi.org\/10.1016\/j.cois.2015.04.016","journal-title":"Curr Opin Insect Sci"},{"key":"9626_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jip.2006.04.004","volume":"93","author":"JD Evans","year":"2006","unstructured":"Evans JD (2006) Bee path: an ordered quantitative-PCR array for exploring honey bee immunity and disease. J Invertebr Pathol 93:135\u2013139. https:\/\/doi.org\/10.1016\/j.jip.2006.04.004","journal-title":"J Invertebr Pathol"},{"key":"9626_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jinsphys.2014.11.005","volume":"72","author":"K Khongphinitbunjong","year":"2015","unstructured":"Khongphinitbunjong K, De Guzman LI, Tarver MR, Rinderer TE, Chen Y, Chantawannakul P (2015) Differential viral levels and immune gene expression in three stocks of Apis mellifera induced by different numbers of Varroa destructor. J Insect Physiol 72:28\u201334. https:\/\/doi.org\/10.1016\/j.jinsphys.2014.11.005","journal-title":"J Insect Physiol"},{"key":"9626_CR15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.pestbp.2015.09.015","volume":"128","author":"I Cizelj","year":"2016","unstructured":"Cizelj I, Glavan G, Bo\u017ei\u010d J, Oven I, Mrak V, Narat M (2016) Prochloraz and coumaphos induce different gene expression patterns in three developmental stages of the Carniolan honey bee (Apis mellifera carnica Pollmann). Pestic Biochem Physiol 128:68\u201375. https:\/\/doi.org\/10.1016\/j.pestbp.2015.09.015","journal-title":"Pestic Biochem Physiol"},{"key":"9626_CR16","doi-asserted-by":"publisher","first-page":"36393","DOI":"10.1371\/journal.pone.0036393","volume":"7","author":"NA Moran","year":"2012","unstructured":"Moran NA, Hansen AK, Powell JE, Sabree ZL (2012) Distinctive gut microbiota of honey bees assessed using deep sampling from individual worker bees. PLoS One 7:36393. https:\/\/doi.org\/10.1371\/journal.pone.0036393","journal-title":"PLoS One"},{"key":"9626_CR17","doi-asserted-by":"publisher","first-page":"11002","DOI":"10.1073\/pnas.1202970109","volume":"109","author":"P Engel","year":"2012","unstructured":"Engel P, Martinson VG, Moran NA (2012) Functional diversity within the simple gut microbiota of the honey bee. Proc Natl Acad Sci U S A 109:11002\u201311007. https:\/\/doi.org\/10.1073\/pnas.1202970109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"9626_CR18","first-page":"95","volume":"3","author":"J Brindza","year":"2010","unstructured":"Brindza J, Gr\u00f3f J, Bacig\u00e1lov\u00e1 K, Ferianc P, T\u00f3th D (2010) Pollen microbial colonization and food safety. Acta Chim Slov 3(1):95\u2013102","journal-title":"Acta Chim Slov"},{"issue":"3","key":"9626_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jee\/tow065","volume":"109","author":"I Janashia","year":"2016","unstructured":"Janashia I, Alaux C (2016) Specific immune stimulation by endogenous bacteria in honey bees (Hymenoptera: Apidae). J Econ Entomol 109(3):1\u20134. https:\/\/doi.org\/10.1093\/jee\/tow065","journal-title":"J Econ Entomol"},{"key":"9626_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jip.2012.09.002","volume":"112","author":"M Yoshiyama","year":"2013","unstructured":"Yoshiyama M, Wu M, Sugimura Y, Takaya N, Kimoto-Nira H, Suzuki C (2013) Inhibition of Paenibacillus larvae by lactic acid bacteria isolated from fermented materials. J Invertebr Pathol 112:62\u201367. https:\/\/doi.org\/10.1016\/j.jip.2012.09.002","journal-title":"J Invertebr Pathol"},{"key":"9626_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.molimm.2018.12.012","volume":"106","author":"Q Wang","year":"2019","unstructured":"Wang Q, Ren M, Liu X, Xia H, Chen K (2019) Peptidoglycan recognition proteins in insect immunity. Mol Immunol 106:69\u201376. https:\/\/doi.org\/10.1016\/j.molimm.2018.12.012","journal-title":"Mol Immunol"},{"issue":"9","key":"9626_CR22","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1111\/mec.14058","volume":"26","author":"O Emery","year":"2017","unstructured":"Emery O, Schmidt K, Engel P (2017) Immune system stimulation by the gut symbiont Frischella perrara in the honey bee (Apis mellifera). Mol Ecol 26(9):2576\u20132590. https:\/\/doi.org\/10.1111\/mec.14058","journal-title":"Mol Ecol"},{"key":"9626_CR23","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nri3089","volume":"11","author":"J Royet","year":"2011","unstructured":"Royet J, Gupta D, Dziarski R (2011) Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nat Rev Immunol 11:837\u2013851. https:\/\/doi.org\/10.1038\/nri3089","journal-title":"Nat Rev Immunol"},{"key":"9626_CR24","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.cois.2015.05.007","volume":"10","author":"G De Grandi-Hoffman","year":"2015","unstructured":"De Grandi-Hoffman G, Chen Y (2015) Nutrition, immunity and viral infections in honey bees. Curr Opin Insect Sci 10:170\u2013176. https:\/\/doi.org\/10.1016\/j.cois.2015.05.007","journal-title":"Curr Opin Insect Sci"},{"key":"9626_CR25","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.ibmb.2013.03.001","volume":"43","author":"AP Louren\u00e7o","year":"2013","unstructured":"Louren\u00e7o AP, Guidugli-Lazzarini KR, Freitas FCP, Bitondi MMG, Sim\u00f5es ZLP (2013) Bacterial infection activates the immune system response and dysregulates microRNA expression in honey bees. Insect Biochem Molec 43:474\u2013482. https:\/\/doi.org\/10.1016\/j.ibmb.2013.03.001","journal-title":"Insect Biochem Molec"},{"issue":"3","key":"9626_CR26","doi-asserted-by":"publisher","first-page":"18126","DOI":"10.1371\/journal.pone.0018126","volume":"6","author":"S Erler","year":"2011","unstructured":"Erler S, Popp M, Lattorff HMG (2011) Dynamics of immune system gene expression upon bacterial challenge and wounding in a social insect (Bombus terrestris). PLoS One 6(3):18126. https:\/\/doi.org\/10.1371\/journal.pone.0018126","journal-title":"PLoS One"},{"issue":"5","key":"9626_CR27","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/imb.12498","volume":"27","author":"AP Louren\u00e7o","year":"2018","unstructured":"Louren\u00e7o AP, Florecki MM, Sim\u00f5es ZLP, Evans JD (2018) Silencing of Apis mellifera dorsal genes reveals their role in expression of the antimicrobial peptide defensin-1. Insect Mol Biol 27(5):577\u2013589. https:\/\/doi.org\/10.1111\/imb.12498","journal-title":"Insect Mol Biol"},{"key":"9626_CR28","doi-asserted-by":"publisher","first-page":"7470","DOI":"10.1073\/pnas.0501860102","volume":"102","author":"X Yang","year":"2005","unstructured":"Yang X, Cox-Foster DL (2005) Impact of an ectoparasite on the immunity and pathology of an invertebrate: evidence for host immunosuppression and viral amplification. Proc Natl Acad Sci U S A 102:7470\u20137475. https:\/\/doi.org\/10.1073\/pnas.0501860102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9626_CR29","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.jinsphys.2012.04.016","volume":"58","author":"V Chaimanee","year":"2012","unstructured":"Chaimanee V, Chantawannakul P, Chen Y, Evans YD, Pettis JS (2012) Differential expression of immune genes of adult honey bee (Apis mellifera) after inoculated by Nosema ceranae. J Insect Physiol 58:1090\u20131095. https:\/\/doi.org\/10.1016\/j.jinsphys.2012.04.016","journal-title":"J Insect Physiol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-019-09626-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12602-019-09626-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-019-09626-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:43:19Z","timestamp":1609893799000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12602-019-09626-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["9626"],"URL":"https:\/\/doi.org\/10.1007\/s12602-019-09626-6","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]},"assertion":[{"value":"7 January 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}