{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:46:57Z","timestamp":1773794817684,"version":"3.50.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12602-020-09651-w","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T03:24:24Z","timestamp":1586661864000},"page":"1542-1554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lactobacillus brevis CD2: Fermentation Strategies and Extracellular Metabolites Characterization"],"prefix":"10.1007","volume":"12","author":[{"given":"Alberto","family":"Alfano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Perillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Savio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Michela","family":"Corsaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Donnarumma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Schiraldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4961-8819","authenticated-orcid":false,"given":"Donatella","family":"Cimini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"9651_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.mimet.2003.11.014","volume":"57","author":"S Vesterlund","year":"2004","unstructured":"Vesterlund S, Paltta J, Laukov\u00e1 A, Karp M, Ouwehand AC (2004) Rapid screening method for the detection of antimicrobial substances. J Microbiol Methods 57:23\u201331. https:\/\/doi.org\/10.1016\/j.mimet.2003.11.014","journal-title":"J Microbiol Methods"},{"key":"9651_CR2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.micpath.2017.05.046","volume":"109","author":"A Mahdhi","year":"2017","unstructured":"Mahdhi A, Leban N, Chakroun I, Chaouch MA, Hafsa J, Fdhila K, Mahdouani K, Majdoub H (2017) Extracellular polysaccharide derived from potential probiotic strain with antioxidant and antibacterial activities as a prebiotic agent to control pathogenic bacterial biofilm formation. Microb Pathog 109:214\u2013220. https:\/\/doi.org\/10.1016\/j.micpath.2017.05.046","journal-title":"Microb Pathog"},{"key":"9651_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.9790\/3013-0220276281","volume":"2","author":"S Tapan Kumar","year":"2012","unstructured":"Tapan Kumar S (2012) Microbial extracellular polymeric substances: production, isolation and applications. Iosr-phr 2:276\u2013281. https:\/\/doi.org\/10.9790\/3013-0220276281","journal-title":"Iosr-phr"},{"key":"9651_CR4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s10295-005-0068-x","volume":"33","author":"C Schiraldi","year":"2006","unstructured":"Schiraldi C, Valli V, Molinaro A, Carten\u00ec M, De Rosa M (2006) Exopolysaccharides production in Lactobacillus bulgaricus and Lactobacillus casei exploiting microfiltration. J Ind Microbiol Biotechnol 33:384\u2013390. https:\/\/doi.org\/10.1007\/s10295-005-0068-x","journal-title":"J Ind Microbiol Biotechnol"},{"key":"9651_CR5","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1007\/s00253-016-7471-2","volume":"100","author":"G Caggianiello","year":"2016","unstructured":"Caggianiello G, Kleerebezem M, Spano G (2016) Exopolysaccharides produced by lactic acid bacteria: from health-promoting benefits to stress tolerance mechanisms. Appl Microbiol Biotechnol 100:3877\u20133886. https:\/\/doi.org\/10.1007\/s00253-016-7471-2","journal-title":"Appl Microbiol Biotechnol"},{"key":"9651_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules23020398","volume":"23","author":"ES Khalil","year":"2018","unstructured":"Khalil ES, Abd Manap MY, Mustafa S, Alhelli AM, Shokryazdan P (2018) Probiotic properties of exopolysaccharide-producing Lactobacillus strains isolated from Tempoyak. Molecules. 23:1\u201320. https:\/\/doi.org\/10.3390\/molecules23020398","journal-title":"Molecules."},{"key":"9651_CR7","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ijbiomac.2017.10.155","volume":"108","author":"Y Abid","year":"2019","unstructured":"Abid Y, Casillo A, Gharsallah H, Joulak I, Lanzetta R, Corsaro MM, Attia H, Azabou S (2019) Production and structural characterization of exopolysaccharides from newly isolated probiotic lactic acid bacteria. Int J Biol Macromol 108:719\u2013728. https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.10.155","journal-title":"Int J Biol Macromol"},{"key":"9651_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.carbpol.2019.04.025","volume":"217","author":"Y Rahbar Saadat","year":"2019","unstructured":"Rahbar Saadat Y, Yari Khosroushahi A, Pourghassem Gargari B (2019) A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides. Carbohydr Polym 217:79\u201389. https:\/\/doi.org\/10.1016\/j.carbpol.2019.04.025","journal-title":"Carbohydr Polym"},{"key":"9651_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fphar.2012.00171","volume":"3","author":"ZQ Toh","year":"2012","unstructured":"Toh ZQ, Anzela A, Tang ML, Licciardi PV (2012) Probiotic therapy as a novel approach for allergic disease. Front Pharmacol 3:171\u2013184. https:\/\/doi.org\/10.3389\/fphar.2012.00171","journal-title":"Front Pharmacol"},{"key":"9651_CR10","first-page":"759","volume":"22","author":"J Sarowska","year":"2013","unstructured":"Sarowska J, Choroszy-Kr\u00f3l I, Regulska-Ilow B, Frej-M\u0105drzak M, Jama-Kmiecik A (2013) The therapeutic effect of probiotic bacteria on gastrointestinal diseases. Adv Clin Exp Med 22:759\u2013766","journal-title":"Adv Clin Exp Med"},{"key":"9651_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/435268","volume":"435268","author":"F Scaldaferri","year":"2013","unstructured":"Scaldaferri F, Gerardi V, Lopetuso LR, Del Zompo F, Mangiola F, Bo\u0161koski I, Bruno G, Petito V, Laterza L, Cammarota G, Gaetani E, Sgambato A, Gasbarrini A (2013) Gut microbial flora, prebiotics, and probiotics in IBD: their current usage and utility. Biomed Res Int 435268:1\u20139. https:\/\/doi.org\/10.1155\/2013\/435268","journal-title":"Biomed Res Int"},{"key":"9651_CR12","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12866-018-1369-3","volume":"18","author":"F Fang","year":"2018","unstructured":"Fang F, Xu J, Li Q, Xia X, Du G (2018) Characterization of a Lactobacillus brevis strain with potential oral probiotic properties. BMC Microbiol 18:221\u2013229. https:\/\/doi.org\/10.1186\/s12866-018-1369-3","journal-title":"BMC Microbiol"},{"key":"9651_CR13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1271\/bbb.61.312","volume":"61","author":"A Hosono","year":"1997","unstructured":"Hosono A, Lee JW, Ametani A, Natsume M, Hirayama M, Adachi T, Kaminogawa S (1997) Characterization of a water-soluble polysaccharide fraction with immunopotentiating activity from Bifidobacterium adolescentis M101-4. Biosci Biotechnol Biochem 61:312\u2013316. https:\/\/doi.org\/10.1271\/bbb.61.312","journal-title":"Biosci Biotechnol Biochem"},{"key":"9651_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1475-2859-9-85","volume":"9","author":"H Li","year":"2010","unstructured":"Li H, Qiu T, Huang G, Cao Y (2010) Production of gamma-aminobutyric acid by Lactobacillus brevis NCL912 using fed-batch fermentation. Microb Cell Factories 9:85\u201391. https:\/\/doi.org\/10.1186\/1475-2859-9-85","journal-title":"Microb Cell Factories"},{"key":"9651_CR15","unstructured":"Karamese M, Aydin H, Sengul E, Gelen V, Sevim C, Ustek D, Karakus E (2016) The Immunostimulatory effect of lactic acid bacteria in a rat model. Iran J Immunol 13:220-228. IJIv13i3A7"},{"key":"9651_CR16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3168\/jds.S0022-0302(93)77483-4","volume":"63","author":"H Kitazawa","year":"1991","unstructured":"Kitazawa H, Toba T, Itoh T, Kumano N, Adachi S, Yamaguchi T (1991) Antitumoral activity of slime-forming, encapsulated Lactococcus lactis subsp. cremoris isolated from scandinavian ropy sour milk, Viili. Anim Sci Technol 63:277\u2013283. https:\/\/doi.org\/10.3168\/jds.S0022-0302(93)77483-4","journal-title":"Anim Sci Technol"},{"key":"9651_CR17","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.foodres.2019.05.002","volume":"123","author":"MS Riaz Rajoka","year":"2019","unstructured":"Riaz Rajoka MS, Zhao H, Mehwish HM, Li N, Lu Y, Lian Z, Shao D, Jin M, Li Q, Zhao L, Shi J (2019) Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk. Food Res Int 123:286\u2013297. https:\/\/doi.org\/10.1016\/j.foodres.2019.05.002","journal-title":"Food Res Int"},{"key":"9651_CR18","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12906-019-2528-2","volume":"19","author":"LO Chuah","year":"2019","unstructured":"Chuah LO, Foo HL, Loh TC, Mohammed Alitheen NB, Yeap SK, Abdul Mutalib NE, Abdul Rahim R, Yusoff K (2019) Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells. BMC Complement Altern Med 19:114\u2013125. https:\/\/doi.org\/10.1186\/s12906-019-2528-2","journal-title":"BMC Complement Altern Med"},{"key":"9651_CR19","doi-asserted-by":"publisher","first-page":"17127","DOI":"10.1002\/jcp.28473","volume":"234","author":"M Eslami","year":"2019","unstructured":"Eslami M, Yousefi B, Kokhaei P, Hemati M, Nejad ZR, Arabkari V, Namdar A (2019) Importance of probiotics in the prevention and treatment of colorectal cancer. J Cell Physiol 234:17127\u201317143. https:\/\/doi.org\/10.1002\/jcp.28473","journal-title":"J Cell Physiol"},{"key":"9651_CR20","doi-asserted-by":"publisher","unstructured":"Nakajima H, Suzuki Y, Kaizu H (1992) Cholesterol lowering activity of ropy fermented milk. J Food Sci:1365\u20132621. https:\/\/doi.org\/10.1111\/j.1365-2621.1992.tb06848.x","DOI":"10.1111\/j.1365-2621.1992.tb06848.x"},{"key":"9651_CR21","doi-asserted-by":"crossref","unstructured":"Kitazawa H, Harata T, Uemura J, Saito T, Kaneko T, Itoh T (1998) Phosphate group requirement for mitogenic activation of lymphocytes by an extracellular phosphopolysaccharide from Lactobacillus delbrueckii ssp. bulgaricus. Int J Food Microbiol 40:169\u2013175. 10.1016\/s0168-1605(98)00030-0","DOI":"10.1016\/S0168-1605(98)00030-0"},{"key":"9651_CR22","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.biortech.2008.07.002","volume":"100","author":"F Freitas","year":"2009","unstructured":"Freitas F, Alves VD, Paism J, Costa N, Oliveira C, Mafrac L, Hilliou L, Oliveira R, Reis MAM (2009) Characterization of an extracellular polysaccharide produced by a Pseudomonas strain grown on glycerol. Bioresour Technol 100:859\u2013865. https:\/\/doi.org\/10.1016\/j.biortech.2008.07.002","journal-title":"Bioresour Technol"},{"key":"9651_CR23","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.procbio.2006.01.014","volume":"41","author":"D Shaofeng","year":"2006","unstructured":"Shaofeng D, Tianwei T (2006) L-lactic acid production by Lactobacillus casei fermentation using different fed-batch feeding strategies. Process Biochem 41:1451\u20131454. https:\/\/doi.org\/10.1016\/j.procbio.2006.01.014","journal-title":"Process Biochem"},{"key":"9651_CR24","doi-asserted-by":"publisher","unstructured":"Oleksy-Sobczak M, Klewicka E (2019) Optimization of media composition to maximize the yield of exopolysaccharides production by Lactobacillus rhamnosus strains. Probiotics Antimicrob Proteins:1\u201310. https:\/\/doi.org\/10.1007\/s12602-019-09581-2","DOI":"10.1007\/s12602-019-09581-2"},{"key":"9651_CR25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.17179\/excli2015-356","volume":"15","author":"Q Liu","year":"2016","unstructured":"Liu Q, Huang X, Yang D, Si T, Pan S, Yang F (2016) Yield improvement of exopolysaccharides by screening of the Lactobacillus acidophilus ATCC and optimization of the fermentation and extraction conditions. EXCLI J 15:119\u2013133. https:\/\/doi.org\/10.17179\/excli2015-356","journal-title":"EXCLI J"},{"key":"9651_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/7356173","volume":"2018","author":"A Abdelazez","year":"2018","unstructured":"Abdelazez A, Abdelmotaal H, Evivie SE, Melak S, Jia FF, Khoso MH, Zhu ZT, Zhang LJ, Sami R, Meng XC (2018) Screening potential probiotic characteristics of Lactobacillus brevis strains in vitro and intervention effect on type I diabetes in vivo. Biomed Res Int 2018:1\u201320. https:\/\/doi.org\/10.1155\/2018\/7356173","journal-title":"Biomed Res Int"},{"key":"9651_CR27","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1139\/cjm-2013-0115","volume":"59","author":"S Suzuki","year":"2013","unstructured":"Suzuki S, Yakabe T, Suganuma H, Fukao M, Saito T, Yajima N (2013) Cell-bound exopolysaccharides of Lactobacillus brevis KB290: protective role and monosaccharide composition. Can J Microbiol 59:549\u2013555. https:\/\/doi.org\/10.1139\/cjm-2013-0115","journal-title":"Can J Microbiol"},{"key":"9651_CR28","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1080\/07315724.1996.10718617","volume":"15","author":"A Kishi","year":"1996","unstructured":"Kishi A, Uno K, Matsubara Y, Okuda C, Kishida T (1996) Effect of the oral administration of Lactobacillus brevis subsp. coagulans on interferon-alpha producing capacity in humans. J Am Coll Nutr 15:408\u2013412. https:\/\/doi.org\/10.1080\/07315724.1996.10718617","journal-title":"J Am Coll Nutr"},{"key":"9651_CR29","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1080\/10408398.2016.1147418","volume":"57","author":"Q Wu","year":"2017","unstructured":"Wu Q, Shah NP (2017) High \u03b3-aminobutyric acid production from lactic acid bacteria: emphasis on Lactobacillus brevis as a functional dairy starter. Crit Rev Food Sci Nutr 57:3661\u20133672. https:\/\/doi.org\/10.1080\/10408398.2016.1147418","journal-title":"Crit Rev Food Sci Nutr"},{"key":"9651_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.fm.2017.08.006","volume":"69","author":"Q Wu","year":"2018","unstructured":"Wu Q, Shap NP (2018) Restoration of GABA production machinery in Lactobacillus brevis by accessible carbohydrates, anaerobiosis and early acidification. Food Microbiol 69:151\u2013158. https:\/\/doi.org\/10.1016\/j.fm.2017.08.006","journal-title":"Food Microbiol"},{"issue":"3","key":"9651_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0060521","volume":"8","author":"M Fukao","year":"2013","unstructured":"Fukao M, Oshima K, Morita H, Toh H, Suda W, Kim SW, Suzuki S, Yakabe T, Hattori M, Yajima N (2013) Genomic analysis by deep sequencing of the probiotic Lactobacillus brevis KB290 harboring nine plasmids reveals genomic stability. PLoS One 8(3):1\u201310. https:\/\/doi.org\/10.1371\/journal.pone.0060521","journal-title":"PLoS One"},{"issue":"19","key":"9651_CR32","doi-asserted-by":"publisher","first-page":"30063","DOI":"10.1016\/j.jbiosc.2019.04.008","volume":"S1389-1723","author":"M Fukao","year":"2019","unstructured":"Fukao M, Zendo T, Inoue T, Nakayama J, Suzuki S, Fukaya T, Yajima N, Sonomoto K (2019) Plasmid-encoded glycosyltransferase operon is responsible for exopolysaccharide production, cell aggregation, and bile resistance in a probiotic strain, Lactobacillus brevis KB290. J Biosci Bioeng S1389-1723(19):30063\u201330065. https:\/\/doi.org\/10.1016\/j.jbiosc.2019.04.008","journal-title":"J Biosci Bioeng"},{"key":"9651_CR33","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1751-0759-6-16","volume":"6","author":"K Murakami","year":"2012","unstructured":"Murakami K, Habukawa C, Nobuta Y, Moriguchi N, Takemura T (2012) The effect of Lactobacillus brevis KB290 against irritable bowel syndrome: a placebo controlled double-blind crossover trial. Biopsychosoc Med 6:16\u201323. https:\/\/doi.org\/10.1186\/1751-0759-6-16","journal-title":"Biopsychosoc Med"},{"key":"9651_CR34","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1080\/09637486.2017.1311843","volume":"68","author":"N Fuke","year":"2017","unstructured":"Fuke N, Aizawa K, Suganuma H, Takagi T, Naito Y (2017) Effect of combined consumption of Lactobacillus brevis KB290 and b-carotene on minor diarrhea-predominant irritable bowel syndrome-like symptoms in healthysubjects: a randomised, double-blind, placebo-controlled, parallel-group trial. Int J Food Sci Nutr 68:973\u2013986. https:\/\/doi.org\/10.1080\/09637486.2017.1311843","journal-title":"Int J Food Sci Nutr"},{"key":"9651_CR35","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/lam.12340","volume":"59","author":"N Waki","year":"2014","unstructured":"Waki N, Matsumono M, Fukui Y, Suganuma H (2014) Effects of probiotic Lactobacillus brevis KB290 on incidence of influenza infection among school children. Lett Appl Microbiol 59:565\u2013571. https:\/\/doi.org\/10.1111\/lam.12340","journal-title":"Lett Appl Microbiol"},{"issue":"6","key":"9651_CR36","doi-asserted-by":"publisher","first-page":"e000138","DOI":"10.1136\/esmoopen-2016-000138","volume":"1","author":"A Sharma","year":"2017","unstructured":"Sharma A, Tilak T, Bakhshi S, Raina V, Kumar L, Chaudhary SP, Sahoo RK, Gupta R, Thulkar S (2017) Lactobacillus brevis CD2 lozenges prevent oral mucositis in patients undergoing high dose chemotherapy followed by haematopoietic stem cell transplantation. SMO Open 1(6):e000138. https:\/\/doi.org\/10.1136\/esmoopen-2016-000138","journal-title":"SMO Open"},{"key":"9651_CR37","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1083-4389.2004.00214.x","volume":"9","author":"M Linsalata","year":"2004","unstructured":"Linsalata M, Russo F, Berloco P, Caruso ML, Matteo GD, Cifone MG, Simone CD, Ierardi E, Di Leo A (2004) The influence of Lactobacillus brevis on ornithine decarboxylase activity and polyamine profiles in Helicobacter pylori-infected gastric mucosa. Helicobacter 9:165\u2013172. https:\/\/doi.org\/10.1111\/j.1083-4389.2004.00214.x","journal-title":"Helicobacter"},{"key":"9651_CR38","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1601-0825.2006.01291.x","volume":"13","author":"DN Riccia","year":"2007","unstructured":"Riccia DN, Bizzini F, Perilli MG, Polimeni A, Trinchieri V, Amicosante G, Cifone MG (2007) Anti-inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease. Oral Dis 13:376\u2013378. https:\/\/doi.org\/10.1111\/j.1601-0825.2006.01291.x","journal-title":"Oral Dis"},{"key":"9651_CR39","first-page":"107","volume":"45","author":"AS Shrikant","year":"2007","unstructured":"Shrikant AS, Parag SS, Ishwar BB, Rekha S (2007) Fermentative production, downstream processing and applications. Food Technol Biotechnol 45:107\u2013118","journal-title":"Food Technol Biotechnol"},{"key":"9651_CR40","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/odi.12186","volume":"20","author":"C Vuotto","year":"2014","unstructured":"Vuotto C, Barbanti F, Mastrantonio P, Donelli G (2014) Lactobacillus brevis CD2 inhibits Prevotella melaninogenica biofilm. Oral Dis 20:668\u2013674. https:\/\/doi.org\/10.1111\/odi.12186","journal-title":"Oral Dis"},{"key":"9651_CR41","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1007\/s00253-009-2261-8","volume":"85","author":"D Cimini","year":"2010","unstructured":"Cimini D, Restaino OF, Catapano A, De Rosa M, Schiraldi C (2010) Production of capsular polysaccharide from Escherichia coli K4 for biotechnological applications. Appl Microbiol Biotechnol 85:1779\u20131787. https:\/\/doi.org\/10.1007\/s00253-009-2261-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"9651_CR42","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1021\/ac60083a023","volume":"25","author":"TA Scott","year":"1953","unstructured":"Scott TA, Melvin EH (1953) Determination of dextran with anthrone. Anal Chem 25:1656\u20131661. https:\/\/doi.org\/10.1021\/ac60083a023","journal-title":"Anal Chem"},{"key":"9651_CR43","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.1007\/s00253-019-09969-8","volume":"103","author":"D Cimini","year":"2019","unstructured":"Restaino OF, Cimini D, Cassese E, Ventriglia R, Alfano A, Marrazzo A, D\u2019ambrosio S, Barbuto Ferraiuolo S, De Rosa M, Schiraldi C (2019) Molecular weight determination of heparosan- and chondroitin-like capsular polysaccharides: figuring out differences between wild type and engineered Escherichia coli strains. Appl Microbiol Biotechnol 103:6771\u20136782. https:\/\/doi.org\/10.1007\/s00253-019-09969-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"9651_CR44","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0378-1097(03)00214-3","volume":"221","author":"S Petry","year":"2003","unstructured":"Petry S, Furlan S, Waghorne E, Saulnier L, Cerning L, Maguin E (2003) Comparison of the thickening properties of four Lactobacillus delbrueckii subsp. bulgaricus strains and physicochemical characterization of their exopolysaccharides. FEMS Microbiol Lett 221:285\u2013291. https:\/\/doi.org\/10.1016\/S0378-1097(03)00214-3","journal-title":"FEMS Microbiol Lett"},{"key":"9651_CR45","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s10482-017-0834-6","volume":"110","author":"A Casillo","year":"2017","unstructured":"Casillo A, St\u00e5hle J, Parrilli E, Sannino F, Mitchell DE, Pieretti G, Lanetta R, Parrilli M, Widmalm G, Tutino ML, Corsaro MM (2017) Structural characterization of an all-amino sugar-containing capsular polysaccharide from Colwellia psychrerythraea 34H. Antonie Leeuwenhoek 110:1377\u20131387. https:\/\/doi.org\/10.1007\/s10482-017-0834-6","journal-title":"Antonie Leeuwenhoek"},{"key":"9651_CR46","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.carbpol.2016.09.037","volume":"156","author":"A Casillo","year":"2017","unstructured":"Casillo A, Parrilli E, Sannino F, Mitchell DE, Gibson MI, Marino G, Lanzetta R, Parrilli M, Cosconati S, Novellino E, Randazzo A, Tutino ML, Corsaro MM (2017) Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: a strategy for cryoprotection. Carbohydr Polym 156:364\u2013371. https:\/\/doi.org\/10.1016\/j.carbpol.2016.09.037","journal-title":"Carbohydr Polym"},{"key":"9651_CR47","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","volume":"6","author":"M Balouiri","year":"2016","unstructured":"Balouiri M, Sadiki M, Ibnsouda SK (2016) Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal 6:71\u201379. https:\/\/doi.org\/10.1016\/j.jpha.2015.11.005","journal-title":"J Pharm Anal"},{"key":"9651_CR48","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1590\/S1517-83822007000200034","volume":"38","author":"C Valgas","year":"2007","unstructured":"Valgas C, de Souza SM, Sm\u00e2nia EFA, Sm\u00e2nia A Jr (2007) Screening methods to determine antibacterial activity of natural products. Braz J Microbiol 38:369\u2013380. https:\/\/doi.org\/10.1590\/S1517-83822007000200034","journal-title":"Braz J Microbiol"},{"key":"9651_CR49","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1574-6968.1990.tb04885.x","volume":"87","author":"SW Lindgren","year":"1990","unstructured":"Lindgren SW, Dobrogosz WJ (1990) Antagonistic activities of lactic acid bacteria in food and feed fermentations. FEMS Microbiol Rev 87:149\u2013164. https:\/\/doi.org\/10.1111\/j.1574-6968.1990.tb04885.x","journal-title":"FEMS Microbiol Rev"},{"key":"9651_CR50","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jbiosc.2014.06.003","volume":"119","author":"Y Wang","year":"2015","unstructured":"Wang Y, Tashiro Y, Sonomoto K (2015) Fermentative production of lactic acid from renewable materials: recent achievements, prospects, and limits. J Biosci Bioeng 119:10\u201318. https:\/\/doi.org\/10.1016\/j.jbiosc.2014.06.003","journal-title":"J Biosci Bioeng"},{"key":"9651_CR51","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jrras.2014.03.002","volume":"7","author":"T Ghaffar","year":"2014","unstructured":"Ghaffar T, Irshad M, Anwar Z, Aqil T, Zulifqar Z, Tariq A, Kamran M, Ehsan N, Mehmood S (2014) Recent trends in lactic acid biotechnology: a brief review on production to purification. J Radiat Res Appl Sc 7:222\u2013229. https:\/\/doi.org\/10.1016\/j.jrras.2014.03.002","journal-title":"J Radiat Res Appl Sc"},{"key":"9651_CR52","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1016\/j.biortech.2009.10.047","volume":"101","author":"EJ Aguirre-Ezkauriatza","year":"2010","unstructured":"Aguirre-Ezkauriatza EJ, Aguilar-Y\u00e1\u00f1ez JM, Ram\u00edrez-Medrano A, Alvarez MM (2010) Production of probiotic biomass (Lactobacillus casei) in goat milk whey: comparison of batch, continuous and fed-batch cultures. Bioresour Technol 101:2837\u20132844. https:\/\/doi.org\/10.1016\/j.biortech.2009.10.047","journal-title":"Bioresour Technol"},{"key":"9651_CR53","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1016\/j.biotechadv.2018.10.007","volume":"36","author":"V Juturu","year":"2018","unstructured":"Juturu V, Wu JC (2018) Microbial production of bacteriocins: latest research development and applications. Biotechnol Adv 36:2187\u20132200. https:\/\/doi.org\/10.1016\/j.biotechadv.2018.10.007","journal-title":"Biotechnol Adv"},{"key":"9651_CR54","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jbiotec.2017.07.033","volume":"259","author":"N Vivek","year":"2017","unstructured":"Vivek N, Aswathi TV, Sven PR, Pandey A, Binod P (2017) Self-cycling fermentation for 1,3-propanediol production: comparative evaluation of metabolite flux in cell recycling, simple batch and continuous processes using Lactobacillus brevis N1E9.3.3 strain. J Biotechnol 259:110\u2013119. https:\/\/doi.org\/10.1016\/j.jbiotec.2017.07.033","journal-title":"J Biotechnol"},{"key":"9651_CR55","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.jbiosc.2017.10.003","volume":"125","author":"M Hasegawa","year":"2018","unstructured":"Hasegawa M, Yamane D, Funato K, Yoshida A, Sambongi Y (2018) Gamma-aminobutyric acid fermentation with date residue by a lactic acid bacterium, Lactobacillus brevis. J Biosci Bioeng 125:316\u2013319. https:\/\/doi.org\/10.1016\/j.jbiosc.2017.10.003","journal-title":"J Biosci Bioeng"},{"key":"9651_CR56","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.3389\/fmicb.2019.01541","volume":"10","author":"C Xie","year":"2019","unstructured":"Xie C, Coda R, Chamlagain B, Varmanen P, Piironen V, Katina K (2019) Co-fermentation of Propionibacterium freudenreichii and Lactobacillus brevis in wheat bran for in situ production of vitamin B12. Front Microbiol 10:1541\u20131551. https:\/\/doi.org\/10.3389\/fmicb.2019.01541","journal-title":"Front Microbiol"},{"key":"9651_CR57","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jbiosc.2014.10.027","volume":"119","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Vadlani PV (2015) Lactic acid production from biomass-derived sugars via co-fermentation of Lactobacillus brevis and Lactobacillus plantarum. J Biosci Bioeng 119:694\u2013699. https:\/\/doi.org\/10.1016\/j.jbiosc.2014.10.027","journal-title":"J Biosci Bioeng"},{"key":"9651_CR58","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1159\/000322350","volume":"156","author":"CY Li","year":"2011","unstructured":"Li CY, Lin HC, Lai CH, Lu JJ, Wu SF, Fang SH (2011) Immunomodulatory effects of Lactobacillus and Bifidobacterium on both murine and human mitogen-activated T cells. Int Arch Allergy Immunol 156:128\u2013136. https:\/\/doi.org\/10.1159\/000322350","journal-title":"Int Arch Allergy Immunol"},{"key":"9651_CR59","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00284-012-0186-4","volume":"65","author":"DP Neveling","year":"2012","unstructured":"Neveling DP, Endo A, Dicks LMT (2012) Fructophilic Lactobacillus kunkeei and Lactobacillus brevis isolated from fresh flowers, bees and bee-hives. Curr Microbiol 65:507\u2013515. https:\/\/doi.org\/10.1007\/s00284-012-0186-4","journal-title":"Curr Microbiol"},{"key":"9651_CR60","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/btpr.2037","volume":"31","author":"A Alfano","year":"2015","unstructured":"Alfano A, Donnarumma G, Cimini D, Fusco A, Marzaioli I, De Rosa M, Schiraldi C (2015) Lactobacillus plantarum: microfiltration experiments for the production of probiotic biomass to be used in food and nutraceutical preparations. Biotechnol Prog 31:325\u2013333. https:\/\/doi.org\/10.1002\/btpr.2037","journal-title":"Biotechnol Prog"},{"key":"9651_CR61","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/bit.10557","volume":"2003","author":"C Schiraldi","year":"2003","unstructured":"Schiraldi C, Adduci V, Valli V, Maresca C, Giuliano M, Lamberti M, Carteni M, De Rosa M (2003) High cell density cultivation of probiotics and lactic acid production. Biotechnol Bioeng 2003:213\u2013222. https:\/\/doi.org\/10.1002\/bit.10557","journal-title":"Biotechnol Bioeng"},{"key":"9651_CR62","unstructured":"Schlothauer RC, Morgan AJ, Rademacher I, Christensen T, Martel I (2004) Use of lactobacillus to produce exopolysaccharides in food and pharmaceutical compositions WO2004013343 (A2)"},{"key":"9651_CR63","doi-asserted-by":"publisher","first-page":"7818","DOI":"10.1128\/AEM.02377-13","volume":"79","author":"T Sun Kang","year":"2013","unstructured":"Sun Kang T, Korber DR, Tanaka T (2013) Regulation of dual glycolytic pathways for fructose metabolism in heterofermentative Lactobacillus panis PM1. Appl Environ Microbiol 79:7818\u20137826. https:\/\/doi.org\/10.1128\/AEM.02377-13","journal-title":"Appl Environ Microbiol"},{"key":"9651_CR64","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1128\/AEM.01659-17","volume":"17","author":"T Guo","year":"2017","unstructured":"Guo T, Zhang L, Xin Y, Xu Z, He H, Kong J (2017) Oxygen-inducible conversion of lactate to acetate in heterofermentative Lactobacillus brevis ATCC 367. Appl Environ Microbiol 17:83\u2013104. https:\/\/doi.org\/10.1128\/AEM.01659-17","journal-title":"Appl Environ Microbiol"},{"key":"9651_CR65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1475-2859-8-28","volume":"8","author":"R Brooijmans","year":"2009","unstructured":"Brooijmans R, Smit B, Santos F, Riel JV, deVos WM, Hugenholtz J (2009) Heme and menaquinone induced electron transport in lactic acid bacteria. Microb Cell Factories 8:28\u201338. https:\/\/doi.org\/10.1186\/1475-2859-8-28","journal-title":"Microb Cell Factories"},{"key":"9651_CR66","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1128\/AEM.66.2.606-613.2000","volume":"66","author":"R Callewaert","year":"2000","unstructured":"Callewaert R, De Vuyst L (2000) Bacteriocin production with Lactobacillus amylovorus DCE471 is improved and stabilized by fed-batch fermentation. Appl Environ Microbiol 66:606\u2013613","journal-title":"Appl Environ Microbiol"},{"key":"9651_CR67","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.enzmictec.2007.03.009","volume":"41","author":"LP Castro","year":"2007","unstructured":"Castro LP, Bernardez PF, Guerra NP, Guseva EV, Fick M (2007) Fed-batch pediocin production on whey using different feeding media. Enzym Microb Technol 41:397\u2013406","journal-title":"Enzym Microb Technol"},{"key":"9651_CR68","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.procbio.2007.09.001","volume":"42","author":"FM Racine","year":"2007","unstructured":"Racine FM, Saha BC (2007) Production of mannitol by Lactobacillus intermedius NRRL B-3693 in fed-batch and continuous cell-recycle fermentations. Process Biochem 42:1609\u20131613","journal-title":"Process Biochem"},{"key":"9651_CR69","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1556\/AAlim.42.2013.2.9","volume":"42","author":"M Polak-Bereckaa","year":"2013","unstructured":"Polak-Bereckaa M, Wa\u015bko A, Skrzypekb H, Kreftc A (2013) Production of exopolysaccharides by a probiotic strain of Lactobacillus rhamnosus: biosynthesis and purification methods. Acta Aliment 42:220\u2013228. https:\/\/doi.org\/10.1556\/AAlim.42.2013.2.9","journal-title":"Acta Aliment"},{"key":"9651_CR70","first-page":"341","volume":"45","author":"BI Bajaj","year":"2007","unstructured":"Bajaj BI, Survase SA, Saudagar PS, Singhal RS (2007) Gellan gum: fermentative production, downstream processing and applications. Food Technol Biotechnol 45:341\u2013354","journal-title":"Food Technol Biotechnol"},{"key":"9651_CR71","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.tibtech.2011.03.008","volume":"29","author":"F Freitas","year":"2011","unstructured":"Freitas F, Alves VD, Reis AM (2011) Advances in bacterial exopolysaccharides: from production to biotechnological applications. Trends Biotechnol 29:388\u2013398. https:\/\/doi.org\/10.1016\/j.tibtech.2011.03.008","journal-title":"Trends Biotechnol"},{"key":"9651_CR72","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/jre.12164","volume":"49","author":"T Maekawa","year":"2014","unstructured":"Maekawa T, Hajishengallis G (2014) Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. Periodontal Res 49:785\u2013791. https:\/\/doi.org\/10.1111\/jre.12164","journal-title":"Periodontal Res"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-020-09651-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-020-09651-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-020-09651-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T23:27:41Z","timestamp":1618183661000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-020-09651-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,12]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["9651"],"URL":"https:\/\/doi.org\/10.1007\/s12602-020-09651-w","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,12]]},"assertion":[{"value":"12 April 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no conflict of interest.Bioteknet s.p.a. is a public body of which the L. Vanvitelli University is the majority shareholder.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}