{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:54:38Z","timestamp":1792853678398,"version":"4.5.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12602-020-09652-9","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T10:02:35Z","timestamp":1587290555000},"page":"1300-1309","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["A Review of the Role of Probiotic Supplementation in Dental Caries"],"prefix":"10.1007","volume":"12","author":[{"given":"Bhagavathi Sundaram","family":"Sivamaruthi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periyanaina","family":"Kesika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaiyavat","family":"Chaiyasut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"issue":"19","key":"9652_CR1","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","volume":"192","author":"FE Dewhirst","year":"2010","unstructured":"Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, Lakshmanan A, Wade WG (2010) The human oral microbiome. J Bacteriol 192(19):5002\u20135017","journal-title":"J Bacteriol"},{"issue":"3","key":"9652_CR2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.4161\/21505594.2014.983783","volume":"6","author":"RP Allaker","year":"2015","unstructured":"Allaker RP, Ian Douglas CW (2015) Non-conventional therapeutics for oral infections. Virulence 6(3):196\u2013207","journal-title":"Virulence"},{"issue":"6 Suppl 1","key":"9652_CR3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1875-595X.2004.tb00009.x","volume":"54","author":"PE Petersen","year":"2004","unstructured":"Petersen PE (2004) Challenges to improvement of oral health in the 21st century - the approach of the WHO Global Oral Health Programme. Int Dent J 54(6 Suppl 1):329\u2013343","journal-title":"Int Dent J"},{"issue":"5","key":"9652_CR4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0022034517750572","volume":"97","author":"AJ Righolt","year":"2018","unstructured":"Righolt AJ, Jevdjevic M, Marcenes W, Listl S (2018) Global-, regional-, and country-level economic impacts of dental diseases in 2015. J Dent Res 97(5):501\u2013507","journal-title":"J Dent Res"},{"issue":"3","key":"9652_CR5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jphd.12141","volume":"76","author":"CY Atkins","year":"2016","unstructured":"Atkins CY, Thomas TK, Lenaker D, Day GM, Hennessy TW, Meltzer MI (2016) Cost-effectiveness of preventing dental caries and full mouth dental reconstructions among Alaska Native children in the Yukon-Kuskokwim delta region of Alaska. J Public Health Dent 76(3):228\u2013240","journal-title":"J Public Health Dent"},{"issue":"4","key":"9652_CR6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/10454411950060040401","volume":"6","author":"TM Hassell","year":"1995","unstructured":"Hassell TM, Harris EL (1995) Genetic influences in caries and periodontal diseases. Crit Rev Oral Biol Med 6(4):319\u2013342","journal-title":"Crit Rev Oral Biol Med"},{"issue":"8","key":"9652_CR7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1538-5442(03)00093-2","volume":"33","author":"DM Krol","year":"2003","unstructured":"Krol DM (2003) Dental caries, oral health, and pediatricians. Curr Probl Pediatr Adolesc Health Care 33(8):253\u2013270","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"issue":"3","key":"9652_CR8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/19424396.2003.12224161","volume":"31","author":"JD Featherstone","year":"2003","unstructured":"Featherstone JD, Adair SM, Anderson MH, Berkowitz RJ, Bird WF, Crall JJ, Den Besten PK, Donly KJ, Glassman P, Milgrom P, Roth JR, Snow R, Stewart RE (2003) Caries management by risk assessment: consensus statement, April 2002. J Calif Dent Assoc 31(3):257\u2013269","journal-title":"J Calif Dent Assoc"},{"issue":"9555","key":"9652_CR9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","volume":"369","author":"RH Selwitz","year":"2007","unstructured":"Selwitz RH, Ismail AI, Pitts NB (2007) Dental caries. Lancet 369(9555):51\u201359","journal-title":"Lancet"},{"issue":"3","key":"9652_CR10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/2221-1691.228000","volume":"8","author":"BS Sivamaruthi","year":"2018","unstructured":"Sivamaruthi BS (2018) A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases. Asian Pac J Trop Biomed 8(3):179\u2013186","journal-title":"Asian Pac J Trop Biomed"},{"issue":"12","key":"9652_CR11","doi-asserted-by":"publisher","first-page":"E1973","DOI":"10.3390\/nu10121973","volume":"10","author":"BS Sivamaruthi","year":"2018","unstructured":"Sivamaruthi BS, Kesika P, Prasanth MI, Chaiyasut C (2018) A mini review on antidiabetic properties of fermented foods. Nutrients 10(12):E1973. https:\/\/doi.org\/10.3390\/nu10121973","journal-title":"Nutrients"},{"issue":"6","key":"9652_CR12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.22159\/ijap.2018v10i6.29156","volume":"10","author":"BS Sivamaruthi","year":"2018","unstructured":"Sivamaruthi BS, Kesika P, Chaiyasut C (2018) Influence of probiotic supplementation on climacteric symptoms in menopausal women-a mini review. Int J Appl Pharm 10(6):43\u201346","journal-title":"Int J Appl Pharm"},{"issue":"5","key":"9652_CR13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.22159\/ijap.2018v10i5.28249","volume":"10","author":"BS Sivamaruthi","year":"2018","unstructured":"Sivamaruthi BS, Kesika P, Chaiyasut C (2018) A review on anti-aging properties of probiotics. Int J Appl Pharm 10(5):23\u201327","journal-title":"Int J Appl Pharm"},{"issue":"6","key":"9652_CR14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4103\/2221-1691.235328","volume":"8","author":"BS Sivamaruthi","year":"2018","unstructured":"Sivamaruthi BS, Kesika P, Chaiyasut C (2018) Probiotic based therapy for atopic dermatitis: outcomes of clinical studies. Asian Pac J Trop Biomed 8(6):328\u2013332","journal-title":"Asian Pac J Trop Biomed"},{"key":"9652_CR15","doi-asserted-by":"publisher","first-page":"3291367","DOI":"10.1155\/2019\/3291367","volume":"2019","author":"BS Sivamaruthi","year":"2019","unstructured":"Sivamaruthi BS, Kesika P, Suganthy N, Chaiyasut C (2019) A review on role of microbiome in obesity and antiobesity properties of probiotic supplements. Biomed Res Int 2019:3291367\u20133291320. https:\/\/doi.org\/10.1155\/2019\/3291367","journal-title":"Biomed Res Int"},{"issue":"4","key":"9652_CR16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.4314\/tjpr.v18i4.29","volume":"18","author":"BS Sivamaruthi","year":"2019","unstructured":"Sivamaruthi BS, Prasanth MI, Kesika P, Chaiyasut C (2019) Probiotics in human mental health and diseases-a mini review. Trop J Pharm Res 18(4):889\u2013895","journal-title":"Trop J Pharm Res"},{"key":"9652_CR17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/scipharm87040026","volume":"87","author":"BS Sivamaruthi","year":"2019","unstructured":"Sivamaruthi BS, Kesika P, Chaiyasut C (2019) A mini-review of human studies on cholesterol-lowering properties of probiotics. Sci Pharm 87:26. https:\/\/doi.org\/10.3390\/scipharm87040026","journal-title":"Sci Pharm"},{"key":"9652_CR18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-0722.2005.00191.x","volume":"113","author":"JH Meurman","year":"2005","unstructured":"Meurman JH (2005) Probiotics: do they have a role in oral medicine and dentistry? Eur J Oral Sci 113:188\u2013196","journal-title":"Eur J Oral Sci"},{"key":"9652_CR19","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7502","volume":"7","author":"N Hasan","year":"2019","unstructured":"Hasan N, Yang H (2019) Factors affecting the composition of the gut microbiota, and its modulation. PeerJ 7:e7502. https:\/\/doi.org\/10.7717\/peerj.7502","journal-title":"PeerJ"},{"issue":"6","key":"9652_CR20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1159\/000488948","volume":"52","author":"F Manji","year":"2018","unstructured":"Manji F, Dahlen G, Fejerskov O (2018) Caries and periodontitis: contesting the conventional wisdom on their aetiology. Caries Res 52(6):548\u2013564","journal-title":"Caries Res"},{"issue":"11","key":"9652_CR21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1177\/154405910808701104","volume":"87","author":"BJ Keijser","year":"2008","unstructured":"Keijser BJ, Zaura E, Huse SM, van der Vossen JM, Schuren FH, Montjin RC, ten Cate JM, Crielaard W (2008) Pyrosequencing analysis of the oral microflora of healthy adults. J Dent Res 87(11):1016\u20131020","journal-title":"J Dent Res"},{"issue":"3","key":"9652_CR22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1462-2920.12502","volume":"17","author":"X Xu","year":"2015","unstructured":"Xu X, He J, Xue J, Wang Y, Li K, Zhang K, Guo Q, Liu X, Zhou Y, Cheng L, Li M, Li Y, Li Y, Shi W, Zhou X (2015) Oral cavity contains distinct niches with dynamic microbial communities. Environ Microbiol 17(3):699\u2013710","journal-title":"Environ Microbiol"},{"issue":"2","key":"9652_CR23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000345367","volume":"47","author":"B Nyvad","year":"2013","unstructured":"Nyvad B, Crielaard W, Mira A, Takahashi N, Beighton D (2013) Dental caries from a molecular microbiological perspective. Caries Res 47(2):89\u2013102","journal-title":"Caries Res"},{"issue":"4","key":"9652_CR24","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1128\/JCM.01410-07","volume":"46","author":"JA Aas","year":"2008","unstructured":"Aas JA, Griffen AL, Dardis SR, Lee AM, Olsen I, Dewhirst FE, Leys EJ, Paster BJ (2008) Bacteria of dental caries in primary and permanent teeth in children and young adults. J Clin Microbiol 46(4):1407\u20131417","journal-title":"J Clin Microbiol"},{"issue":"11","key":"9652_CR25","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","volume":"43","author":"JA Aas","year":"2005","unstructured":"Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43(11):5721\u20135732","journal-title":"J Clin Microbiol"},{"key":"9652_CR26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fcimb.2015.00010","volume":"5","author":"MI Klein","year":"2015","unstructured":"Klein MI, Hwang G, Santos PH, Campanella OH, Koo H (2015) Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms. Front Cell Infect Microbiol 5:10. https:\/\/doi.org\/10.3389\/fcimb.2015.00010","journal-title":"Front Cell Infect Microbiol"},{"issue":"10","key":"9652_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164242","volume":"11","author":"J Xiao","year":"2016","unstructured":"Xiao J, Moon Y, Li L, Rustchenko E, Wakabayashi H, Zhao X, Feng C, Gill SR, McLaren S, Malmstrom H, Ren Y, Quivey R, Koo H, Kopycka-Kedzierawski DT (2016) Candida albicans carriage in children with severe early childhood caries (S-ECC) and maternal relatedness. PLoS One 11(10):e0164242. https:\/\/doi.org\/10.1371\/journal.pone.0164242","journal-title":"PLoS One"},{"issue":"4","key":"9652_CR28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/odi.12691","volume":"24","author":"D Pereira","year":"2018","unstructured":"Pereira D, Seneviratne CJ, Koga-Ito CY, Samaranayake LP (2018) Is the oral fungal pathogen Candida albicans a cariogen? Oral Dis 24(4):518\u2013526","journal-title":"Oral Dis"},{"issue":"11","key":"9652_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2017.35","volume":"9","author":"AS Hemadi","year":"2017","unstructured":"Hemadi AS, Huang R, Zhou Y, Zou J (2017) Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment. Int J Oral Sci 9(11):e1. https:\/\/doi.org\/10.1038\/ijos.2017.35","journal-title":"Int J Oral Sci"},{"issue":"1\u20132","key":"9652_CR30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000481833","volume":"52","author":"J Xiao","year":"2018","unstructured":"Xiao J, Huang X, Alkhers N, Alzamil H, Alzoubi S, Wu TT, Castillo DA, Campbell F, Davis J, Herzog K, Billings R, Kopycka-Kedzierawski DT, Hajishengallis E, Koo H (2018) Candida albicans and early childhood caries: a systematic review and meta-analysis. Caries Res 52(1\u20132):102\u2013112","journal-title":"Caries Res"},{"issue":"9 Suppl","key":"9652_CR31","doi-asserted-by":"crossref","first-page":"110S","DOI":"10.1177\/0022034515576052","volume":"94","author":"PW Caufield","year":"2015","unstructured":"Caufield PW, Sch\u00f6n CN, Saraithong P, Li Y, Argim\u00f3n S (2015) Oral Lactobacilli and dental caries: a model for niche adaptation in humans. J Dent Res 94(9 Suppl):110S\u2013118S","journal-title":"J Dent Res"},{"issue":"4","key":"9652_CR32","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/JCM.02427-10","volume":"49","author":"AC Tanner","year":"2011","unstructured":"Tanner AC, Mathney JM, Kent RL, Chalmers NI, Hughes CV, Loo CY, Pradhan N, Kanasi E, Hwang J, Dahlan MA, Papadopolou E, Dewhirst FE (2011) Cultivable anaerobic microbiota of severe early childhood caries. J Clin Microbiol 49(4):1464\u20131474","journal-title":"J Clin Microbiol"},{"issue":"12","key":"9652_CR33","doi-asserted-by":"crossref","first-page":"E1978","DOI":"10.3390\/ijms17121978","volume":"17","author":"S Jiang","year":"2016","unstructured":"Jiang S, Gao X, Jin L, Lo EC (2016) Salivary microbiome diversity in caries-free and caries-affected children. International Int J Mol Sci 17(12):E1978","journal-title":"International Int J Mol Sci"},{"issue":"12","key":"9652_CR34","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1177\/0022034517718819","volume":"96","author":"M Agnello","year":"2017","unstructured":"Agnello M, Marques J, Cen L, Mittermuller B, Huang A, Chaichanasakul Tran N, Shi W, He X, Schroth RJ (2017) Microbiome associated with severe caries in Canadian First Nations children. J Dent Res 96(12):1378\u20131385","journal-title":"J Dent Res"},{"issue":"4","key":"9652_CR35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1177\/0022034509360010","volume":"89","author":"E Kanasi","year":"2010","unstructured":"Kanasi E, Johansson I, Lu SC, Kressin NR, Nunn ME, Kent R Jr, Tanner AC (2010) Microbial risk markers for childhood caries in pediatricians\u2019 offices. J Dent Res 89(4):378\u2013383","journal-title":"J Dent Res"},{"issue":"12","key":"9652_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000785","volume":"5","author":"M Ventura","year":"2009","unstructured":"Ventura M, Turroni F, Zomer A, Foroni E, Giubellini V, Bottacini F, Canchaya C, Claesson MJ, He F, Mantzourani M, Mulas L, Ferrarini A, Gao B, Delledonne M, Henrissat B, Coutinho P, Oggioni M, Gupta RS, Zhang Z, Beighton D, Fitzgerald GF, O'Toole PW, van Sinderen D (2009) The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS Genet 5(12):e1000785. https:\/\/doi.org\/10.1371\/journal.pgen.1000785","journal-title":"PLoS Genet"},{"issue":"3","key":"9652_CR37","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1128\/JCM.40.3.1001-1009.2002","volume":"40","author":"MR Becker","year":"2002","unstructured":"Becker MR, Paster BJ, Leys EJ, Moeschberger ML, Kenyon SG, Galvin JL, Boches SK, Dewhirst FE, Griffen AL (2002) Molecular analysis of bacterial species associated with childhood caries. J Clin Microbiol 40(3):1001\u20131009","journal-title":"J Clin Microbiol"},{"issue":"6","key":"9652_CR38","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1375\/twin.10.6.821","volume":"10","author":"PM Corby","year":"2007","unstructured":"Corby PM, Bretz WA, Hart TC, Schork NJ, Wessel J, Lyons-Weiler J, Paster BJ (2007) Heritability of oral microbial species in caries-active and caries-free twins. Twin Res Hum Genet 10(6):821\u2013828","journal-title":"Twin Res Hum Genet"},{"issue":"13","key":"9652_CR39","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1128\/JB.00276-08","volume":"190","author":"J Kreth","year":"2008","unstructured":"Kreth J, Zhang Y, Herzberg MC (2008) Streptococcal antagonism in oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans. J Bacteriol 190(13):4632\u20134640","journal-title":"J Bacteriol"},{"key":"9652_CR40","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1755-8794-4-22","volume":"4","author":"W Crielaard","year":"2011","unstructured":"Crielaard W, Zaura E, Schuller AA, Huse SM, Montijn RC, Keijser BJ (2011) Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health. BMC Med Genet 4:22. https:\/\/doi.org\/10.1186\/1755-8794-4-22","journal-title":"BMC Med Genet"},{"issue":"10","key":"9652_CR41","doi-asserted-by":"crossref","first-page":"e47722","DOI":"10.1371\/journal.pone.0047722","volume":"7","author":"EL Gross","year":"2012","unstructured":"Gross EL, Beall CJ, Kutsch SR, Firestone ND, Leys EJ, Griffen AL (2012) Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis. PLoS One 7(10):e47722","journal-title":"PLoS One"},{"issue":"4","key":"9652_CR42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/archdischild-2017-313196","volume":"103","author":"NPT Innes","year":"2018","unstructured":"Innes NPT, Robertson MD (2018) Recent advances in the management of childhood dental caries. Arch Dis Child 103(4):311\u2013315","journal-title":"Arch Dis Child"},{"issue":"6","key":"9652_CR43","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1159\/000047484","volume":"35","author":"L N\u00e4se","year":"2001","unstructured":"N\u00e4se L, Hatakka K, Savilahti E, Saxelin M, P\u00f6nk\u00e4 A, Poussa T, Korpela R, Meurman JH (2001) Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res 35(6):412\u2013420","journal-title":"Caries Res"},{"issue":"4","key":"9652_CR44","first-page":"221","volume":"5","author":"S Pohjavuori","year":"2010","unstructured":"Pohjavuori S, Ahola AJ, Yli-Knuuttila H, Piirainen L, Poussa T, Meurman JH, Korpela R (2010) Effect of consumption of Lactobacillus rhamnosus GG and calcium, in carrot-pineapple juice on dental caries risk in children. Int J Probiotics Prebiotics 5(4):221\u2013228","journal-title":"Int J Probiotics Prebiotics"},{"issue":"1","key":"9652_CR45","first-page":"56","volume":"16","author":"N Cort\u00e9s-Dorantes","year":"2015","unstructured":"Cort\u00e9s-Dorantes N, Ruiz-Rodr\u00edguez MS, Karakowsky-Kleiman L, Garrocho-Rangel JA, S\u00e1nchez-Vargas LO, Pozos-Guill\u00e9n AJ (2015) Probiotics and their effect on oral bacteria count in children: a pilot study. Eur J Paediatr Dent 16(1):56\u201360","journal-title":"Eur J Paediatr Dent"},{"issue":"1","key":"9652_CR46","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12903-015-0096-5","volume":"15","author":"T Hedayati-Hajikand","year":"2015","unstructured":"Hedayati-Hajikand T, Lundberg U, Eldh C, Twetman S (2015) Effect of probiotic chewing tablets on early childhood caries - a randomized controlled trial. BMC Oral Health 15(1):112. https:\/\/doi.org\/10.1186\/s12903-015-0096-5","journal-title":"BMC Oral Health"},{"issue":"4","key":"9652_CR47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF03262809","volume":"12","author":"G Jindal","year":"2011","unstructured":"Jindal G, Pandey RK, Agarwal J, Singh M (2011) A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children. Eur Arch Paediatr Dent 12(4):211\u2013215","journal-title":"Eur Arch Paediatr Dent"},{"issue":"Pt 6","key":"9652_CR48","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1099\/jmm.0.056663-0","volume":"62","author":"JP Burton","year":"2013","unstructured":"Burton JP, Drummond BK, Chilcott CN, Tagg JR, Thomson WM, Hale JD, Wescombe PA (2013) Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: a randomized double-blind, placebo-controlled trial. J Med Microbiol 62(Pt 6):875\u2013884","journal-title":"J Med Microbiol"},{"issue":"1","key":"9652_CR49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.17796\/jcpd.38.1.b481624264142082","volume":"38","author":"M Cannon","year":"2013","unstructured":"Cannon M, Trent B, Vorachek A, Kramer S, Esterly R (2013) Effectiveness of CRT at measuring the salivary level of bacteria in caries prone children with probiotic therapy. J Clin Pediatr Dent 38(1):55\u201360","journal-title":"J Clin Pediatr Dent"},{"issue":"2","key":"9652_CR50","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000354412","volume":"48","author":"M Stensson","year":"2014","unstructured":"Stensson M, Koch G, Coric S, Abrahamsson TR, Jenmalm MC, Birkhed D, Wendt LK (2014) Oral administration of Lactobacillus reuteri during the first year of life reduces caries prevalence in the primary dentition at 9 years of age. Caries Res 48(2):111\u2013117","journal-title":"Caries Res"},{"issue":"5","key":"9652_CR51","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000235581","volume":"43","author":"C Stecks\u00e9n-Blicks","year":"2009","unstructured":"Stecks\u00e9n-Blicks C, Sj\u00f6str\u00f6m I, Twetman S (2009) Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study. Caries Res 43(5):374\u2013381","journal-title":"Caries Res"},{"key":"9652_CR52","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2147\/CCIDE.S93066","volume":"7","author":"F Di Pierro","year":"2015","unstructured":"Di Pierro F, Zanvit A, Nobili P, Risso P, Fornaini C (2015) Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study. Clin Cosmet Investig Dent 7:107\u2013113","journal-title":"Clin Cosmet Investig Dent"},{"issue":"3","key":"9652_CR53","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jebdp.2017.07.005","volume":"17","author":"EK Kaye","year":"2017","unstructured":"Kaye EK (2017) Daily intake of probiotic lactobacilli may reduce caries risk in young children. J Evid Based Dent Pract 17(3):284\u2013286","journal-title":"J Evid Based Dent Pract"},{"issue":"2","key":"9652_CR54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jds.2016.09.005","volume":"12","author":"YJ Lin","year":"2017","unstructured":"Lin YJ, Chou CC, Hsu CS (2017) Effects of Lactobacillus casei Shirota intake on caries risk in children. J Dent Sci 12(2):179\u2013184","journal-title":"J Dent Sci"},{"issue":"5","key":"9652_CR55","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4103\/jioh.jioh_170_18","volume":"10","author":"K Kaur","year":"2018","unstructured":"Kaur K, Nekkanti S, Madiyal M, Choudhary P (2018) Effect of chewing gums containing probiotics and xylitol on oral health in children: a randomized controlled trial. J Int Oral Health 10(5):237\u2013243","journal-title":"J Int Oral Health"},{"issue":"2","key":"9652_CR56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/dj3020043","volume":"3","author":"R Teanpaisan","year":"2015","unstructured":"Teanpaisan R, Piwat S, Tianviwat S, Sophatha B, Kampoo T (2015) Effect of long-term consumption of Lactobacillus paracasei SD1 on reducing mutans streptococci and caries risk: a randomized placebo-controlled trial. Dent J (Basel) 3(2):43\u201354","journal-title":"Dent J (Basel)"},{"issue":"5","key":"9652_CR57","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/00016357.2018.1453083","volume":"76","author":"N Pahumunto","year":"2018","unstructured":"Pahumunto N, Piwat S, Chankanka O, Akkarachaneeyakorn N, Rangsitsathian K, Teanpaisan R (2018) Reducing mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children: a randomized placebo-controlled trial. Acta Odontol Scand 76(5):331\u2013337","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"9652_CR58","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jds.2019.01.008","volume":"14","author":"N Pahumunto","year":"2019","unstructured":"Pahumunto N, Sophatha B, Piwat S, Teanpaisan R (2019) Increasing salivary IgA and reducing Streptococcus mutans by probiotic Lactobacillus paracasei SD1: a double-blind, randomized, controlled study. J Dent Sci 14(2):178\u2013184","journal-title":"J Dent Sci"},{"issue":"6","key":"9652_CR59","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1159\/000350524","volume":"47","author":"P Hassl\u00f6f","year":"2013","unstructured":"Hassl\u00f6f P, West CE, Videhult FK, Brandelius C, Stecks\u00e9n-Blicks C (2013) Early intervention with probiotic Lactobacillus paracasei F19 has no long-term effect on caries experience. Caries Res 47(6):559\u2013565","journal-title":"Caries Res"},{"key":"9652_CR60","doi-asserted-by":"publisher","first-page":"e20170318","DOI":"10.1590\/1678-7757-2017-0318","volume":"26","author":"J Villavicencio","year":"2018","unstructured":"Villavicencio J, Villegas LM, Arango MC, Arias S, Triana F (2018) Effects of a food enriched with probiotics on Streptococcus mutans and Lactobacillus spp. salivary counts in preschool children: a cluster randomized trial. J Appl Oral Sci 26:e20170318. https:\/\/doi.org\/10.1590\/1678-7757-2017-0318","journal-title":"J Appl Oral Sci"},{"issue":"10","key":"9652_CR61","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.14147","volume":"43","author":"S Piwat","year":"2019","unstructured":"Piwat S, Pahumunto N, Srisommai P, Mapaisansin C, Teanpaisan R (2019) Effect of probiotic delivery vehicles for probiotic Lactobacillus rhamnosus SD11 in caries prevention: a clinical study. J Food Process Preserv 43(10):e14147. https:\/\/doi.org\/10.1111\/jfpp.14147","journal-title":"J Food Process Preserv"},{"key":"9652_CR62","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s40368-019-00468-y","volume":"21","author":"MP Angarita-D\u00edaz","year":"2019","unstructured":"Angarita-D\u00edaz MP, Forero-Escobar D, Cer\u00f3n-Bastidas XA, Cisneros-Hidalgo CA, D\u00e1vila-Narvaez F, Bedoya-Correa CM, Freitas SC, Cabrera-Arango CL, Melo-Colina R (2019) Effects of a functional food supplemented with probiotics on biological factors related to dental caries in children: a pilot study. Eur Arch Paediatr Dent 21:161\u2013169. https:\/\/doi.org\/10.1007\/s40368-019-00468-y","journal-title":"Eur Arch Paediatr Dent"},{"issue":"11","key":"9652_CR63","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0003-9969(02)00112-7","volume":"47","author":"AJ Ahola","year":"2002","unstructured":"Ahola AJ, Yli-Knuuttila H, Suomalainen T, Poussa T, Ahlstr\u00f6m A, Meurman JH, Korpela R (2002) Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors. Arch Oral Biol 47(11):799\u2013804","journal-title":"Arch Oral Biol"},{"issue":"6","key":"9652_CR64","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/00016350510020070","volume":"63","author":"E Caglar","year":"2005","unstructured":"Caglar E, Sandalli N, Twetman S, Kavaloglu S, Ergeneli S, Selvi S (2005) Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adult. Acta Odontol Scand 63(6):317\u2013320","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"9652_CR65","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1365-2672.2009.04243.x","volume":"107","author":"RT Zahradnik","year":"2009","unstructured":"Zahradnik RT, Magnusson I, Walker C, McDonell E, Hillman CH, Hillman JD (2009) Preliminary assessment of safety and effectiveness in humans of ProBiora3\u2122 a probiotic mouthwash. J Appl Microbiol 107(2):682\u2013690","journal-title":"J Appl Microbiol"},{"issue":"7","key":"9652_CR66","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ejcn.2011.45","volume":"65","author":"S Slawik","year":"2011","unstructured":"Slawik S, Staufenbiel I, Schilke R, Nicksch S, Weinspach K, Stiesch M, Eberhard J (2011) Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans. Eur J Clin Nutr 65(7):857\u2013863","journal-title":"Eur J Clin Nutr"},{"issue":"4","key":"9652_CR67","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00784-010-0423-9","volume":"15","author":"LC Chuang","year":"2011","unstructured":"Chuang LC, Huang CS, Ou-Yang LW, Lin SY (2011) Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora. Clin Oral Investig 15(4):471\u2013476","journal-title":"Clin Oral Investig"},{"issue":"3","key":"9652_CR68","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00784-013-1057-5","volume":"18","author":"R Teanpaisan","year":"2014","unstructured":"Teanpaisan R, Piwat S (2014) Lactobacillus paracasei SD1, a novel probiotic, reduces mutans streptococci in human volunteers: a randomized placebo-controlled trial. Clin Oral Investig 18(3):857\u2013862","journal-title":"Clin Oral Investig"},{"key":"9652_CR69","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1472-6831-14-110","volume":"14","author":"T Nishihara","year":"2014","unstructured":"Nishihara T, Suzuki N, Yoneda M, Hirofuji T (2014) Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial. BMC Oral Health 14:110. https:\/\/doi.org\/10.1186\/1472-6831-14-110","journal-title":"BMC Oral Health"},{"issue":"6","key":"9652_CR70","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/00016357.2011.568962","volume":"69","author":"LG Petersson","year":"2011","unstructured":"Petersson LG, Magnusson K, Hakestam U, Baigi A, Twetman S (2011) Reversal of primary root caries lesions after daily intake of milk supplemented with fluoride and probiotic lactobacilli in older adults. Acta Odontol Scand 69(6):321\u2013327","journal-title":"Acta Odontol Scand"},{"issue":"3","key":"9652_CR71","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/jioh.jioh_82_18","volume":"10","author":"RTC Tandelilin","year":"2018","unstructured":"Tandelilin RTC, Widita E, Agustina D, Saini R (2018) The effect of oral probiotic consumption on the caries risk factors among high-risk caries population. J Int Oral Health 10(3):132\u2013137","journal-title":"J Int Oral Health"},{"issue":"7","key":"9652_CR72","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1128\/AEM.03887-15","volume":"82","author":"X Huang","year":"2016","unstructured":"Huang X, Palmer SR, Ahn SJ, Richards VP, Williams ML, Nascimento MM, Burne R (2016) A highly arginolytic Streptococcus species that potently antagonizes Streptococcus mutans. Appl Environ Microbiol 82(7):2187\u20132201","journal-title":"Appl Environ Microbiol"},{"key":"9652_CR73","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3389\/fmicb.2017.00379","volume":"8","author":"A L\u00f3pez-L\u00f3pez","year":"2017","unstructured":"L\u00f3pez-L\u00f3pez A, Camelo-Castillo A, Ferrer MD, Simon-Soro \u00c1, Mira A (2017) Health-associated niche inhabitants as oral probiotics: the case of Streptococcus dentisani. Front Microbiol 8:379. https:\/\/doi.org\/10.3389\/fmicb.2017.00379","journal-title":"Front Microbiol"},{"issue":"3","key":"9652_CR74","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1099\/mic.0.000237","volume":"162","author":"GV Walker","year":"2016","unstructured":"Walker GV, Heng NCK, Carne A, Tagg JR, Wescombe PA (2016) Salivaricin E and abundant dextranase activity may contribute to the anti-cariogenic potential of the probiotic candidate Streptococcus salivarius JH. Microbiology 162(3):476\u2013486","journal-title":"Microbiology"},{"key":"9652_CR75","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12903-015-0003-0","volume":"15","author":"O Wattanarat","year":"2015","unstructured":"Wattanarat O, Makeudom A, Sastraruji T, Piwat S, Tianviwat S, Teanpaisan R, Krisanaprakornkit S (2015) Enhancement of salivary human neutrophil peptide 1-3 levels by probiotic supplementation. BMC Oral Health 15:19. https:\/\/doi.org\/10.1186\/s12903-015-0003-0","journal-title":"BMC Oral Health"},{"issue":"5","key":"9652_CR76","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000348424","volume":"47","author":"T Taipale","year":"2013","unstructured":"Taipale T, Pienih\u00e4kkinen K, Alanen P, Jokela J, S\u00f6derling E (2013) Administration of Bifidobacterium animalis subsp. lactis bb-12 in early childhood: a post-trial effect on caries occurrence at four years of age. Caries Res 47(5):364\u2013372","journal-title":"Caries Res"},{"issue":"1","key":"9652_CR77","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/ejo\/cjv015","volume":"38","author":"S Gizani","year":"2016","unstructured":"Gizani S, Petsi G, Twetman S, Caroni C, Makou M, Papagianoulis L (2016) Effect of the probiotic bacterium Lactobacillus reuteri on white spot lesion development in orthodontic patients. Eur J Orthod 38(1):85\u201389","journal-title":"Eur J Orthod"},{"issue":"2","key":"9652_CR78","first-page":"107","volume":"3","author":"Y Lee","year":"2013","unstructured":"Lee Y (2013) Diagnosis and prevention strategies for dental caries. J Lifestyle Med 3(2):107\u2013109","journal-title":"J Lifestyle Med"},{"key":"9652_CR79","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.3389\/fmicb.2018.03323","volume":"9","author":"JL Baker","year":"2019","unstructured":"Baker JL, Edlund A (2019) Exploiting the oral microbiome to prevent tooth decay: has evolution already provided the best tools? Front Microbiol 9:3323. https:\/\/doi.org\/10.3389\/fmicb.2018.03323","journal-title":"Front Microbiol"},{"issue":"3","key":"9652_CR80","first-page":"262","volume":"4","author":"MM Nascimento","year":"2019","unstructured":"Nascimento MM, Alvarez AJ, Huang X, Hanway S, Perry S, Luce A, Richards VP, Burne RA (2019) Arginine metabolism in supragingival oral biofilms as a potential predictor of caries risk. JDR Clin Trans Res 4(3):262\u2013270","journal-title":"JDR Clin Trans Res"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-020-09652-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-020-09652-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-020-09652-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:26:45Z","timestamp":1696044405000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-020-09652-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,19]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["9652"],"URL":"https:\/\/doi.org\/10.1007\/s12602-020-09652-9","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,19]]},"assertion":[{"value":"19 April 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}