{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:57:34Z","timestamp":1766181454440,"version":"3.37.3"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Research Foundation of SA"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12602-020-09688-x","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T16:04:58Z","timestamp":1598371498000},"page":"1310-1320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Does the Future of Antibiotics Lie in Secondary Metabolites Produced by Xenorhabdus spp.? A Review"],"prefix":"10.1007","volume":"12","author":[{"given":"E.","family":"Booysen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-9046","authenticated-orcid":false,"given":"L. M. T.","family":"Dicks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"9688_CR1","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/JB.00275-16","volume":"198","author":"RM Stubbendieck","year":"2016","unstructured":"Stubbendieck RM, Straight PD (2016) Multifaceted interfaces of bacterial competition. J Bacteriol 198:2145\u20132155","journal-title":"J Bacteriol"},{"key":"9688_CR2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrmicro2259","volume":"8","author":"ME Hibbing","year":"2010","unstructured":"Hibbing ME, Fuqua C, Parsek MR, Peterson BS (2010) Bacterial competition: surviving and thriving in the microbial jungle. Nat Rev Micro 8:15\u201325","journal-title":"Nat Rev Micro"},{"key":"9688_CR3","doi-asserted-by":"crossref","first-page":"E1639","DOI":"10.1073\/pnas.1323632111","volume":"111","author":"W Kim","year":"2014","unstructured":"Kim W, Racimo F, Schluter J, Levy SB, Foster KR (2014) Importance of positioning for microbial evolution. Proc Natl Acad Sci U S A 111:E1639\u2013E1647","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9688_CR4","doi-asserted-by":"crossref","first-page":"18891","DOI":"10.1073\/pnas.1212429109","volume":"109","author":"M Asally","year":"2012","unstructured":"Asally M, Kittisopikul M, Ru\u00e9 P, Du Y, Hu Z, \u00c7a\u011fatay T, Robison AB, Lu H, Garcia-Ojalvo J, S\u00fcel GM (2012) Localized cell death focuses mechanical forces during 3D patterning in a biofilm. Proc Natl Acad Sci U S A 109:18891\u201318896","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9688_CR5","doi-asserted-by":"crossref","unstructured":"Kreth J, Zhang Y, Herzberg MC (2008) Streptococcal antagonism in oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans. J Bacteriol 2008 190: 4632\u20134640","DOI":"10.1128\/JB.00276-08"},{"key":"9688_CR6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/0022034513498598","volume":"92","author":"X Zheng","year":"2013","unstructured":"Zheng X, Zhang K, Zhou X, Liu C, Li M, Li Y, Wang R, Li Y, Li J, Shi W, Xu X (2013) Involvement of gshAB in the interspecies competition within oral biofilm. J Dent Res 92:819\u2013824","journal-title":"J Dent Res"},{"key":"9688_CR7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijfoodmicro.2003.12.004","volume":"93","author":"J Chen","year":"2004","unstructured":"Chen J, Lee SM, Mao Y (2004) Protective effect of exopolysaccharide colanic acid of Escherichia coli O157:H7 to osmotic and oxidative stress. Int J Food Microbiol 93:281\u2013286","journal-title":"Int J Food Microbiol"},{"key":"9688_CR8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature12365","volume":"500","author":"MG Prokopenko","year":"2013","unstructured":"Prokopenko MG, Hirst MB, De Brabandere L, Lawrence DJP, Berelson WM, Granger J, Chang BX, Dawson S, Crane EJ, Chong L, Thamdrup B, Townsend-Small A, Sigman DM (2013) Nitrogen losses in anoxic marine sediments driven by Thioploca-anammox bacterial consortia. Nature 500:194\u2013198","journal-title":"Nature"},{"key":"9688_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1002787","volume":"8","author":"S Koskiniemi","year":"2012","unstructured":"Koskiniemi S, Sun S, Berg OG, Andersson DI (2012) Selection-driven gene loss in bacteria. PLoS Genet 8:1\u20138","journal-title":"PLoS Genet"},{"key":"9688_CR10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tig.2015.05.004","volume":"31","author":"JJ Morris","year":"2015","unstructured":"Morris JJ (2015) Black Queen evolution: the role of leakiness in structuring microbial communities. Trends Genet 31:475\u2013482","journal-title":"Trends Genet"},{"key":"9688_CR11","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/ismej.2012.46","volume":"6","author":"DR Johnson","year":"2012","unstructured":"Johnson DR, Goldschmidt F, Lilja EE, Achermann (2012) Metabolic specialization and the assembly of microbial communities. ISME J 6:1985\u20131991","journal-title":"ISME J"},{"key":"9688_CR12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.7748\/ns.25.38.49.s53","volume":"24","author":"G Kaufman","year":"2011","unstructured":"Kaufman G (2011) Antibiotics: mode of action and mechanisms of resistance. Nurs Stand 24:49\u201355","journal-title":"Nurs Stand"},{"key":"9688_CR13","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.addr.2005.04.003","volume":"57","author":"PA Lambert","year":"2005","unstructured":"Lambert PA (2005) Bacterial resistance to antibiotics: modified target sites. Adv Drug Deliv Rev 57:1471\u20131485","journal-title":"Adv Drug Deliv Rev"},{"key":"9688_CR14","doi-asserted-by":"crossref","unstructured":"Peterson E, Kaur P (2018) Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front Microbiol 9 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27227291","DOI":"10.3389\/fmicb.2018.02928"},{"key":"9688_CR15","doi-asserted-by":"crossref","unstructured":"Munita JM, Arias CA (2016) Mechanisms of antibiotic resistance. Microbiol Spectr 4 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27227291","DOI":"10.1128\/microbiolspec.VMBF-0016-2015"},{"key":"9688_CR16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/CMR.00036-08","volume":"22","author":"GA Jacoby","year":"2009","unstructured":"Jacoby GA (2009) AmpC \u0392-Lactamases. Clin Microbiol Rev 22:161\u2013182","journal-title":"Clin Microbiol Rev"},{"key":"9688_CR17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/146837a0","volume":"146","author":"E Abraham","year":"1940","unstructured":"Abraham E, Chain E (1940) An enzyme from bacteria able to destroy penicillin. Nature 146:677\u2013678","journal-title":"Nature"},{"key":"9688_CR18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.micro.56.012302.160310","volume":"56","author":"REW Hancock","year":"2002","unstructured":"Hancock REW, Brinkman FSL (2002) Function of Pseudomonas porins in uptake and efflux. Annu Rev Microbiol 56:17\u201338","journal-title":"Annu Rev Microbiol"},{"key":"9688_CR19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/infdis\/154.2.289","volume":"154","author":"JP Quinn","year":"1986","unstructured":"Quinn JP, Dudek EJ, Divincenzo CA, Lucks DA, Lerner SA (1986) Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections. J Infect Dis 154:289\u2013294","journal-title":"J Infect Dis"},{"key":"9688_CR20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/jac\/dki171","volume":"56","author":"K Poole","year":"2005","unstructured":"Poole K (2005) Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56:20\u201351","journal-title":"J Antimicrob Chemother"},{"key":"9688_CR21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/MMBR.67.4.593-656.2003","volume":"67","author":"H Nikaido","year":"2003","unstructured":"Nikaido H (2003) Molecular basis of bacterial outer membrane permeability revisited. Microbiol Mol Biol Rev 67:593\u2013656","journal-title":"Microbiol Mol Biol Rev"},{"key":"9688_CR22","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1073\/pnas.122108599","volume":"99","author":"MC Enright","year":"2002","unstructured":"Enright MC, Robinson AD, Randle G, Feil EJ, Grundmann H, Spratt BG (2002) The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci U S A 99:7687\u20137692","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9688_CR23","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1128\/AAC.40.4.829","volume":"40","author":"T Grebe","year":"1996","unstructured":"Grebe T, Hakenbeck R (1996) Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of \u03b2-lactam antibiotics. Antimicrob Agents Chemother 40:829\u2013834","journal-title":"Antimicrob Agents Chemother"},{"key":"9688_CR24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AAC.46.3.769-777.2002","volume":"46","author":"PA Ropp","year":"2002","unstructured":"Ropp PA, Hu M, Olesky M, Nicholas RA (2002) Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother 46:769\u2013777","journal-title":"Antimicrob Agents Chemother"},{"key":"9688_CR25","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.257.5073.1064","volume":"257","author":"HC Neu","year":"1992","unstructured":"Neu HC (1992) The crisis in antibiotic resistance. Science 257:1064\u20131073","journal-title":"Science"},{"key":"9688_CR26","first-page":"1","volume":"8","author":"A Colavecchio","year":"2017","unstructured":"Colavecchio A, Cadieux B, Lo A, Goodridge LD (2017) Bacteriophages contribute to the spread of antibiotic resistance genes among foodborne pathogens of the Enterobacteriaceae family - a review. Front Microbiol 8:1\u201313","journal-title":"Front Microbiol"},{"key":"9688_CR27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0022-2011(91)90160-R","volume":"58","author":"GB Dunphy","year":"1991","unstructured":"Dunphy GB, Webster JM (1991) Antihemocytic surface components of Xenorhabdus nematophilus var. dutki and their modification by serum nonimmune larvae of Galleria mellonella. J Invertebr Pathol 58:40\u201351","journal-title":"J Invertebr Pathol"},{"key":"9688_CR28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jip.2012.02.006","volume":"110","author":"J Yang","year":"2012","unstructured":"Yang J, Zeng H-M, Lin H-F, Yang X-F, Liu Z, Guo L-H, Yuan J-J, Qiu D-W (2012) An insecticidal protein from Xenorhabdus budapestensis that results in prophenoloxidase activation in the wax moth, Galleria mellonella. J Invertebr Pathol 110:60\u201367","journal-title":"J Invertebr Pathol"},{"key":"9688_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2018.03177","volume":"9","author":"J Dreyer","year":"2018","unstructured":"Dreyer J, Malan AP, Dicks LMT (2018) Bacteria of the genus Xenorhabdus, a novel source of bioactive compounds. Front Microbiol 9:1\u201314","journal-title":"Front Microbiol"},{"key":"9688_CR30","doi-asserted-by":"crossref","first-page":"16772","DOI":"10.1002\/chem.201302481","volume":"19","author":"Q Zhou","year":"2013","unstructured":"Zhou Q, Grundmann F, Kaiser M, Schiell M, Gaudriault S, Batzer A, Kurz M, Bode HB (2013) Structure and biosynthesis of xenoamicins from entomopathogenic Xenorhabdus. Chem Eur J 19:16772\u201316779","journal-title":"Chem Eur J"},{"key":"9688_CR31","doi-asserted-by":"crossref","first-page":"17478","DOI":"10.1002\/chem.201403979","volume":"20","author":"M Kronenwerth","year":"2014","unstructured":"Kronenwerth M, Bozh\u00fcy\u00fck KAJ, Kahnt AS, Steinhilber D, Gaudriault S, Kaiser M, Bode HB (2014) Characterisation of taxlllaids A-G; natural products from Xenorhabdus indica. Chem - A Eur J 20:17478\u201317487","journal-title":"Chem - A Eur J"},{"key":"9688_CR32","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1021\/ol2020237","volume":"13","author":"JM Crawford","year":"2011","unstructured":"Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy J (2011) NRPS substrate promiscuity diversifies the xenematides. Org Lett 13:5144\u20135147","journal-title":"Org Lett"},{"key":"9688_CR33","doi-asserted-by":"crossref","first-page":"22072","DOI":"10.1039\/c3ra44721a","volume":"3","author":"F Grundmann","year":"2013","unstructured":"Grundmann F, Kaiser M, Kurz M, Schiell M, Batzer A, Bode HB (2013) Structure determination of the bioactive depsipeptide xenobactin from Xenorhabdus sp. PB30.3. RSC Adv 3:22072\u201322077","journal-title":"RSC Adv"},{"key":"9688_CR34","first-page":"1247","volume":"6","author":"B Ohlendorf","year":"2011","unstructured":"Ohlendorf B, Simon S, Wiese J, Imhoff JF (2011) Szentiamide, an N-formylated cyclic depsipeptide from Xenorhabdus szentirmaii DSM 16338 T. Nat Prod Commun 6:1247\u20131250","journal-title":"Nat Prod Commun"},{"key":"9688_CR35","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3762\/bjoc.8.60","volume":"8","author":"FI Nollmann","year":"2012","unstructured":"Nollmann FI, Dowling A, Kaiser M, Deckmann K, Gr\u00f6sch S, French-Constant R, Bode H (2012) Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum. Beilstein J Org Chem 8:528\u2013533","journal-title":"Beilstein J Org Chem"},{"key":"9688_CR36","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1021\/np500390b","volume":"77","author":"D Reimer","year":"2014","unstructured":"Reimer D, Nollmann FI, Schultz K, Kaiser M, Bode HB (2014) Xenortide biosynthesis by entomopathogenic Xenorhabdus nematophila. J Nat Prod 77:1976\u20131980","journal-title":"J Nat Prod"},{"key":"9688_CR37","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1039\/C8OB00452H","volume":"16","author":"N Esmati","year":"2018","unstructured":"Esmati N, Maddirala AR, Hussein N, Amawi H, Tiwari AK, Andreana PR (2018) Efficient syntheses and anti-cancer activity of xenortides A-D including ent\/epi-stereoisomers. Org Biomol Chem 16:5332\u20135342","journal-title":"Org Biomol Chem"},{"key":"9688_CR38","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1038\/s41467-018-06712-1","volume":"9","author":"C Hacker","year":"2018","unstructured":"Hacker C, Cai X, Kegler C, Zhao L, Weickmann K, Wurm JP, Bode HB, W\u00f6hnert J (2018) Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. Nat Commun 9:4366\u20134377","journal-title":"Nat Commun"},{"key":"9688_CR39","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1021\/acs.orglett.8b01975","volume":"20","author":"L Zhao","year":"2018","unstructured":"Zhao L, Kaiser M, Bode HB (2018) Rhabdopeptide\/xenortide-like peptides from Xenorhabdus innexi with terminal amines showing potent antiprotozoal activity. Org Lett 20:5116\u20135120","journal-title":"Org Lett"},{"key":"9688_CR40","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1021\/ac300372p","volume":"84","author":"SW Fuchs","year":"2012","unstructured":"Fuchs SW, Sachs CC, Kegler C, Nollmann FI, Karas M, Bode HB (2012) Neutral loss fragmentation pattern based screening for arginine-rich natural products in Xenorhabdus and Photorhabdus. Anal Chem 84:6948\u20139655","journal-title":"Anal Chem"},{"key":"9688_CR41","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1039\/c1ob05097d","volume":"9","author":"SW Fuchs","year":"2011","unstructured":"Fuchs SW, Proschak A, Jaskolla TW, Karas M, Bode HB (2011) Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus namtophila. Org Biomol Chem 9:3130\u20133132","journal-title":"Org Biomol Chem"},{"key":"9688_CR42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ja.2009.31","volume":"62","author":"M Gualtieri","year":"2009","unstructured":"Gualtieri M, Aumelas A, Thaler J-O (2009) Identification of a new antimicrobial lysine-rich cyclolipopeptide family from Xenorhabdus nematophila. J Antibiot (Tokyo) 62:295\u2013302","journal-title":"J Antibiot (Tokyo)"},{"key":"9688_CR43","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1021\/acs.orglett.6b03796","volume":"19","author":"X Cai","year":"2017","unstructured":"Cai X, Challinor VL, Zhao L, Reimer D, Adihou H, Gr\u00fcn P, Kaiser M, Bode HB (2017) Biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria. Org Lett 19:806\u2013809","journal-title":"Org Lett"},{"key":"9688_CR44","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1128\/JB.00209-08","volume":"190","author":"J Singh","year":"2008","unstructured":"Singh J, Banerjee N (2008) Transcriptional analysis and functional characterization of a gene pair encoding iron-regulated xenocin and immunity proteins of Xenorhabdus nematophila. J Bacteriol 190:3877\u20133885","journal-title":"J Bacteriol"},{"key":"9688_CR45","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1128\/aem.61.5.2049-2052.1995","volume":"61","author":"JO Thaler","year":"1995","unstructured":"Thaler JO, Baghdiguian S, Boemare N (1995) Purification and characterization of xenorhabdicin, a phage tail-like bacteriocin, from the lysogenic strain F1 of Xenorhabdus nematophilus. Appl Environ Microbiol 61:2049\u20132052","journal-title":"Appl Environ Microbiol"},{"key":"9688_CR46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/cbic.201300694","volume":"15","author":"A Proschak","year":"2014","unstructured":"Proschak A, Zhou Q, Sch\u00f6ner T, Thanwisai A, Kresovic D, Dowling A, Ffrench-constant R, Proschak E, Bode HB (2014) Biosynthesis of the insecticidal xenocyloins in Xenorhabdus bovienii. ChemBioChem 15:369\u2013372","journal-title":"ChemBioChem"},{"key":"9688_CR47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-016-0616-2","volume":"16","author":"S Guo","year":"2017","unstructured":"Guo S, Zhang S, Fang X, Liu Q, Gao J, Bilal M, Wang Y, Zhang X (2017) Regulation of antimicrobial activity and xenocoumacins biosynthesis by pH in Xenorhabdus nematophila. Microb Cell Factories 16:1\u201314","journal-title":"Microb Cell Factories"},{"key":"9688_CR48","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/cbic.201300802","volume":"15","author":"SW Fuchs","year":"2014","unstructured":"Fuchs SW, Grundmann F, Kurz M, Kaiser M, Bode HB (2014) Fabclavines: bioactive peptide \u2013 polyketide-polyamino hybrids from Xenorhabdus. Chem Bio Chem 15:512\u2013516","journal-title":"Chem Bio Chem"},{"key":"9688_CR49","doi-asserted-by":"crossref","first-page":"12086","DOI":"10.1002\/anie.201205384","volume":"51","author":"AO Brachmann","year":"2012","unstructured":"Brachmann AO, Reimer D, Lorenzen W, Alonso EA, Kopp Y, Piel J, Bode HB (2012) Reciprocal cross talk between fatty acid and antibiotic biosynthesis in a nematode symbiont. Angew Chemie - Int Ed 51:12086\u201312089","journal-title":"Angew Chemie - Int Ed"},{"key":"9688_CR50","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.3390\/md11103970","volume":"11","author":"Z Qin","year":"2013","unstructured":"Qin Z, Huang S, Yu Y, Deng H (2013) Dithiolopyrrolone natural products: isolation, synthesis and biosynthesis. Mar Drugs 11:3970\u20133997","journal-title":"Mar Drugs"},{"key":"9688_CR51","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1039\/C3NP70106A","volume":"31","author":"B Li","year":"2014","unstructured":"Li B, Wever WJ, Walsh CT, Bowers AA (2014) Dithiolopyrrolones: biosynthesis, synthesis and activity of a unique class of disulfide containing antibiotics. Nat Prod Rep 31:905\u2013923","journal-title":"Nat Prod Rep"},{"key":"9688_CR52","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/ja.2013.58","volume":"66","author":"J Houard","year":"2013","unstructured":"Houard J, Aumelas A, No\u00ebl T, Pages S, Givaudan A, Fitton-Ouhabi V, Villain-Guillot P, Gaultieri M (2013) Cabanillasin, a new antifungal metabolite, produced by entomopathogenic Xenorhabdus cabanillasii JM26. J Antibiot 66:617\u2013620","journal-title":"J Antibiot"},{"key":"9688_CR53","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1039\/C7NP00010C","volume":"34","author":"J Masschelein","year":"2017","unstructured":"Masschelein J, Jenner M, Challis GL (2017) Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights. Nat Prod Rep 34:712\u2013783","journal-title":"Nat Prod Rep"},{"key":"9688_CR54","doi-asserted-by":"crossref","first-page":"10821","DOI":"10.1073\/pnas.1201160109","volume":"109","author":"JM Crawford","year":"2012","unstructured":"Crawford JM, Portmann C, Zhang X, Roeffaers MBJ, Clardy J (2012) Small molecule perimeter defense in entomopathogenic bacteria. Proc Natl Acad Sci U S A 109:10821\u201310826","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9688_CR55","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.femsle.2004.08.041","volume":"239","author":"D Ji","year":"2004","unstructured":"Ji D, Yi Y, Kang GH, Choi Y-H, Kim P, Baek N-I, Kim Y (2004) Identification of an antibacterial compound, benzylideneacetone, from Xenorhabdus nematophila against major plant-pathogenic bacteria. FEMS Microbiol Lett 239:241\u2013248","journal-title":"FEMS Microbiol Lett"},{"key":"9688_CR56","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.peptides.2012.03.027","volume":"35","author":"Y Xiao","year":"2012","unstructured":"Xiao Y, Meng F, Qiu D, Yang X (2012) Two novel antimicrobial peptides purified from the symbiotic bacteria Xenorhabdus budapestensis NMC-10. Peptides 35:253\u2013260","journal-title":"Peptides"},{"key":"9688_CR57","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1021\/acssynbio.9b00167","volume":"8","author":"ADP Van Staden","year":"2019","unstructured":"Van Staden ADP, Faure LM, Vermeulen RR, Dicks LMT, Smith C (2019) Functional expression of GFP-fused class I lanthipeptides in Escherichia coli. ACS Synth Biol 8:2220\u20132227","journal-title":"ACS Synth Biol"},{"key":"9688_CR58","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.284.5413.486","volume":"284","author":"PJ Belshaw","year":"1999","unstructured":"Belshaw PJ, Walsh CT, Stachelhaus T (1999) Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis. Science 284:486\u2013489","journal-title":"Science"},{"key":"9688_CR59","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1021\/cr960029e","volume":"97","author":"MA Marahiel","year":"1997","unstructured":"Marahiel MA, Stachelhaus T, Mootz HD (1997) Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem Rev 97:2651\u20132674","journal-title":"Chem Rev"},{"key":"9688_CR60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.femsle.2005.08.041","volume":"252","author":"N Roongsawang","year":"2005","unstructured":"Roongsawang N, Siew PL, Washio K, Takano K, Kanaya S, Morikawa M (2005) Phylogenetic analysis of condensation domains in the nonribosomal peptide synthetases. FEMS Microbiol Lett 252:143\u2013151","journal-title":"FEMS Microbiol Lett"},{"key":"9688_CR61","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.chembiol.2016.05.001","volume":"23","author":"DF Ackerley","year":"2016","unstructured":"Ackerley DF (2016) Cracking the nonribosomal code. Cell Chem Biol 23:535\u2013537","journal-title":"Cell Chem Biol"},{"key":"9688_CR62","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/tcr.201100014","volume":"11","author":"M Inoue","year":"2011","unstructured":"Inoue M (2011) Total synthesis and functional analysis of non-ribosomal peptides. Chem Rec 11:284\u2013294","journal-title":"Chem Rec"},{"key":"9688_CR63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40508-016-0057-6","volume":"4","author":"MA Mart\u00ednez-N\u00fa\u00f1ez","year":"2016","unstructured":"Mart\u00ednez-N\u00fa\u00f1ez MA, L\u00f3pez VEL (2016) Nonribosomal peptides synthetases and their applications in industry. Sustain Chem Process 4:13\u201320","journal-title":"Sustain Chem Process"},{"key":"9688_CR64","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1146\/annurev.micro.58.030603.123615","volume":"58","author":"R Finking","year":"2004","unstructured":"Finking R, Marahiel MA (2004) Biosynthesis of nonribosomal peptides. Annu Rev Microbiol 58:4530\u20134488","journal-title":"Annu Rev Microbiol"},{"key":"9688_CR65","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1021\/acssynbio.8b00541","volume":"8","author":"C Steiniger","year":"2019","unstructured":"Steiniger C, Hoffmann S, S\u00fcssmuth RD (2019) Desymmetrization of cyclodepsipeptides by assembly mode switching of iterative nonribosomal peptide synthetases. ACS Synth Biol 8:661\u2013667","journal-title":"ACS Synth Biol"},{"key":"9688_CR66","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.chembiol.2009.03.010","volume":"16","author":"M Juguet","year":"2009","unstructured":"Juguet M, Lautru S, Francou FX, Nezbedov\u00e0 S, Leblond P, Gondry M, Pernodet J-L (2009) An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens. Chem Biol 16:421\u2013431","journal-title":"Chem Biol"},{"key":"9688_CR67","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1039\/c2np20025b","volume":"29","author":"GH Hur","year":"2012","unstructured":"Hur GH, Vickery CR, Burkart MD (2012) Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology. Nat Prod Rep 29:1074\u20131098","journal-title":"Nat Prod Rep"},{"key":"9688_CR68","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.1128\/AEM.01639-15","volume":"81","author":"C Luo","year":"2015","unstructured":"Luo C, Liu X, Zhou X, Guo J, Truong J, Wang X, Xhou H, Li X, Chen Z (2015) Unusual biosynthesis and structure of locillomycins from Bacillus subtilis 916. Appl Environ Microbiol 81:6601\u20136609","journal-title":"Appl Environ Microbiol"},{"key":"9688_CR69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1039\/C6MB00675B","volume":"13","author":"JAE Payne","year":"2017","unstructured":"Payne JAE, Schoppet M, Hansen MH, Cryle MJ (2017) Diversity of nature\u2019s assembly lines-recent discoveries in non-ribosomal peptide synthesis. Mol BioSyst 13:9\u201322","journal-title":"Mol BioSyst"},{"key":"9688_CR70","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-5521(00)00091-0","volume":"7","author":"GL Challis","year":"2000","unstructured":"Challis GL, Ravel J, Townsend CA (2000) Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol 7:211\u2013224","journal-title":"Chem Biol"},{"key":"9688_CR71","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/AAC.43.6.1317","volume":"43","author":"REW Hancock","year":"1999","unstructured":"Hancock REW, Chapple DS (1999) Peptide antibiotics. Antimicrob Agents Chemother 43:1317\u20131323","journal-title":"Antimicrob Agents Chemother"},{"key":"9688_CR72","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.sbi.2004.10.005","volume":"14","author":"GL Challis","year":"2004","unstructured":"Challis GL, Naismith JH (2004) Structural aspects of non-ribosomal peptide biosynthesis. Curr Opin Struct Biol 14:748\u2013756","journal-title":"Curr Opin Struct Biol"},{"key":"9688_CR73","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1002\/anie.201609079","volume":"56","author":"RD S\u00fcssmuth","year":"2017","unstructured":"S\u00fcssmuth RD, Mainz A (2017) Nonribosomal peptide synthesis \u2014 principles and prospects. Angew Chemie - Int Ed 56:3770\u20133821","journal-title":"Angew Chemie - Int Ed"},{"key":"9688_CR74","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1021\/cr0503097","volume":"106","author":"MA Fischbach","year":"2006","unstructured":"Fischbach MA, Walsh CT (2006) Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery and mechanisms. Chem Rev 106:3468\u20133496","journal-title":"Chem Rev"},{"key":"9688_CR75","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10295-013-1322-2","volume":"41","author":"D Barana\u0161i\u0107","year":"2014","unstructured":"Barana\u0161i\u0107 D, Zucko J, Diminic J, Gacesa R, Long PF, Cullum J, Hranueli D, Starcevic A (2014) Predicting substrate specificity of adenylation domains of nonribosomal peptide synthetases and other protein properties by latent semantic indexing. J Ind Microbiol Biotechnol 41:461\u2013467","journal-title":"J Ind Microbiol Biotechnol"},{"key":"9688_CR76","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1039\/c2np20062g","volume":"29","author":"J Crosby","year":"2012","unstructured":"Crosby J, Crump MP (2012) The structural role of the carrier protein - active controller or passive carrier. Nat Prod Rep 29:1111\u20131137","journal-title":"Nat Prod Rep"},{"key":"9688_CR77","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-3375-4_1","volume":"1401","author":"BR Miller","year":"2016","unstructured":"Miller BR, Gulick AM (2016) Structural biology of non-ribosomal peptide synthetases. Methods Mol Biol 1401:3\u201329","journal-title":"Methods Mol Biol"},{"key":"9688_CR78","doi-asserted-by":"crossref","first-page":"12710","DOI":"10.1016\/S0021-9258(18)99934-5","volume":"269","author":"K Hoffmanns","year":"1994","unstructured":"Hoffmanns K, Schneider-scherzers E, Kleinkauf H, Rainer Z (1994) Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis. J Biol Chem 269:12710\u201312714","journal-title":"J Biol Chem"},{"key":"9688_CR79","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1021\/bi00014a017","volume":"34","author":"T Stein","year":"1995","unstructured":"Stein T, Kluge B, Vater J, Franke P, Otto A, Wittmann-Liebold B (1995) Gramicidin S synthetase 1 (phenylalanine racemase), a prototype of amino acid racemases containing the cofactor 4\u2032-phosphopantetheinet. Biochem 34:4633\u20134642","journal-title":"Biochem"},{"key":"9688_CR80","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/anie.201205674","volume":"52","author":"J Chatterjee","year":"2013","unstructured":"Chatterjee J, Rechenmacher F, Kessler H (2013) N-Methylation of peptides and proteins: an important element for modulating biological functions. Angew Chem Int Ed Engl 52:254\u2013269","journal-title":"Angew Chem Int Ed Engl"},{"key":"9688_CR81","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41589-018-0014-7","volume":"14","author":"S Mori","year":"2018","unstructured":"Mori S, Pang AH, Lundy TA, Garzan A, Tsodikov OV, Garneau-Tsodikova S (2018) Structural basis for backbone N-methylation by an interrupted adenylation domain. Nat Chem Biol 14:428\u2013430","journal-title":"Nat Chem Biol"},{"key":"9688_CR82","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1574-6968.1995.tb07328.x","volume":"125","author":"T Stachelhaus","year":"1995","unstructured":"Stachelhaus T, Marahiel MA (1995) Modular structure of genes encoding multifuctional peptide synthetases required for non-ribosomal peptide synthesis. FEMS Microbiol Lett 125:3\u201314","journal-title":"FEMS Microbiol Lett"},{"key":"9688_CR83","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/mben.2000.0171","volume":"3","author":"L Du","year":"2001","unstructured":"Du L, S\u00e1nchez C, Shen B (2001) Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules. Metab Eng 3:78\u201395","journal-title":"Metab Eng"},{"key":"9688_CR84","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1039\/b603600g","volume":"24","author":"S Smith","year":"2007","unstructured":"Smith S, Tsai SC (2007) The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat Prod Rep 24:1041\u20131072","journal-title":"Nat Prod Rep"},{"key":"9688_CR85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2019.00302","volume":"10","author":"S Caulier","year":"2019","unstructured":"Caulier S, Nannan C, Gillis A, Licciardi F, Bragard C, Mahillon J (2019) Overview of the antimicrobial compounds produced by members of the Bacillus subtilis group. Front Microbiol 10:1\u201319","journal-title":"Front Microbiol"},{"key":"9688_CR86","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1002\/anie.200806121","volume":"48","author":"C Hertweck","year":"2009","unstructured":"Hertweck C (2009) The biosynthetic logic of polyketide diversity. Angew Chemie - Int Ed 48:4688\u20134716","journal-title":"Angew Chemie - Int Ed"},{"key":"9688_CR87","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1039\/np9971400523","volume":"14","author":"BJ Rawlings","year":"1997","unstructured":"Rawlings BJ (1997) Biosynthesis of polyketides. Nat Prod Rep 14:523\u2013556","journal-title":"Nat Prod Rep"},{"key":"9688_CR88","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1039\/b704420h","volume":"5","author":"RJ Cox","year":"2007","unstructured":"Cox RJ (2007) Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets. Org Biomol Chem 5:2010\u20132026","journal-title":"Org Biomol Chem"},{"key":"9688_CR89","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jbiotec.2006.03.046","volume":"124","author":"J Sch\u00fcmann","year":"2006","unstructured":"Sch\u00fcmann J, Hertweck C (2006) Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes. J Biotechnol 124:690\u2013703","journal-title":"J Biotechnol"},{"key":"9688_CR90","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00253-015-7093-0","volume":"100","author":"H Chen","year":"2016","unstructured":"Chen H, Du L (2016) Iterative polyketide biosynthesis by modular polyketide synthases in bacteria. Appl Microbiol Biotechnol 100:541\u2013557","journal-title":"Appl Microbiol Biotechnol"},{"key":"9688_CR91","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.282.5386.63","volume":"282","author":"DE Cane","year":"1998","unstructured":"Cane DE, Walsh CT, Khosla C (1998) Harnessing the biosynthetic code: combinations, permutations, and mutations. Science 282:63\u201368","journal-title":"Science"},{"key":"9688_CR92","doi-asserted-by":"crossref","unstructured":"Tang GL, Zhang Z, Pan HX (2017) New insights into bacterial type II polyketide biosynthesis. F1000Research 6: 1\u201312","DOI":"10.12688\/f1000research.10466.1"},{"key":"9688_CR93","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1039\/a909079g","volume":"18","author":"J Staunton","year":"2001","unstructured":"Staunton J, Weissman KJ (2001) Polyketide biosynthesis: a millennium review. Nat Prod Rep 18:380\u2013416","journal-title":"Nat Prod Rep"},{"key":"9688_CR94","doi-asserted-by":"crossref","unstructured":"Katsuyama Y, Ohnishi Y (2012) Type III polyketide synthases in microorganisms. 1st ed. Elsevier Inc.","DOI":"10.1016\/B978-0-12-394290-6.00017-3"},{"key":"9688_CR95","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/14712598.2017.1315402","volume":"17","author":"JM Sierra","year":"2017","unstructured":"Sierra JM, Fust\u00e9 E, Rabanal F, Vinuesa T, Vi\u00f1as M (2017) An overview of antimicrobial peptides and the latest advances in their development. Expert Opin Biol Ther 17:663\u2013676","journal-title":"Expert Opin Biol Ther"},{"key":"9688_CR96","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1128\/JB.00407-09","volume":"191","author":"C Nakano","year":"2009","unstructured":"Nakano C, Ozawa H, Akanuma G, Funa N, Hornouchi S (2009) Biosynthesis of aliphatic polyketides by type III Polyketide synthase and methyltransferase in Bacillus subtilis. J Bacteriol 191:4916\u20134923","journal-title":"J Bacteriol"},{"key":"9688_CR97","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/cbic.200900187","volume":"10","author":"D Reimer","year":"2009","unstructured":"Reimer D, Luxenberger E, Brachmann AO, Bode HB (2009) A new type of pyrrolidine biosynthesis is involved in the late steps of xenocoumacin production in Xenorhabdus nematophila. Chem Bio Chem 10:1997\u20132001","journal-title":"Chem Bio Chem"},{"key":"9688_CR98","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1163\/187529296X00139","volume":"42","author":"G Chen","year":"1996","unstructured":"Chen G, Maxwell P, Dunphy GB, Webster JM (1996) Culture conditions for Xenorhabdus and Photorhabdus symbionts of entomopathogenic nematodes. Nematologica 42:127\u2013130","journal-title":"Nematologica"},{"key":"9688_CR99","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1365-2672.2007.03599.x","volume":"104","author":"YH Wang","year":"2008","unstructured":"Wang YH, Feng JT, Zhang Q, Zhang X (2008) Optimization of fermentation condition for antibiotic production by Xenorhabdus nematophila with response surface methodology. J Appl Microbiol 104:735\u2013744","journal-title":"J Appl Microbiol"},{"key":"9688_CR100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3965851","volume":"2018","author":"C Sa-uth","year":"2018","unstructured":"Sa-uth C, Rattanasena P, Chandrapatya A, Bussaman P (2018) Modification of medium composition for enhancing the production of antifungal activity from Xenorhabdus stockiae PB09 by using response surface methodology. Int J Microbiol 2018:1\u201310 https:\/\/www.hindawi.com\/journals\/ijmicro\/2018\/3965851\/","journal-title":"Int J Microbiol"},{"key":"9688_CR101","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/cbic.201402065","volume":"15","author":"O Schimming","year":"2014","unstructured":"Schimming O, Fleischhacker F, Nollmann FI, Bode HB (2014) Yeast homologous recombination cloning leading to the novel peptides ambactin and xenolindicin. Chem Bio Chem 15:1290\u20131294","journal-title":"Chem Bio Chem"},{"key":"9688_CR102","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/cbic.201500094","volume":"16","author":"E Bode","year":"2015","unstructured":"Bode E, Brachmann AO, Kegler C, Simsek R, Dauth C, Zhou Q, Kaiser M, Klemmt P, Bode HB (2015) Simple \u2018on-demand\u2019 production of bioactive natural products. Chem Bio Chem 16:1115\u20131119","journal-title":"Chem Bio Chem"},{"key":"9688_CR103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.00209","volume":"8","author":"Y Engel","year":"2017","unstructured":"Engel Y, Windhorst C, Lu X, Goodrich-Blair H, Bode HB (2017) The global regulators Lrp, LeuO, and HexA control secondary metabolism in entomopathogenic bacteria. Front Microbiol 8:1\u201313","journal-title":"Front Microbiol"},{"key":"9688_CR104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/207504","volume":"2011","author":"Y Wang","year":"2011","unstructured":"Wang Y, Fang X, Cheng Y, Zhang X (2011) Manipulation of pH shift to enhance the growth and antibiotic activity of Xenorhabdus nematophila. J Biomed Biotechnol 2011:1\u20139","journal-title":"J Biomed Biotechnol"},{"key":"9688_CR105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cub.2009.10.059","volume":"20","author":"JM Crawford","year":"2010","unstructured":"Crawford JM, Kontnik R, Clardy J (2010) Regulating alternative lifestyles in entomopathogenic bacteria. Curr Biol 20:69\u201374","journal-title":"Curr Biol"},{"key":"9688_CR106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2859-10-1","volume":"10","author":"Y Wang","year":"2011","unstructured":"Wang Y, Fang X, An F, Wang G, Zhang X (2011) Improvement of antibiotic activity of Xenorhabdus bovienii by medium optimization using response surface methodology. Microb Cell Factories 10:1\u201315","journal-title":"Microb Cell Factories"},{"key":"9688_CR107","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.biortech.2007.03.053","volume":"99","author":"YH Wang","year":"2008","unstructured":"Wang YH, Li YP, Zhang Q, Zhang X (2008) Enhanced antibiotic activity of Xenorhabdus nematophila by medium optimization. Bioresour Technol 99:1708\u20131715","journal-title":"Bioresour Technol"},{"key":"9688_CR108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkr648","volume":"40","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Werling U, Edelmann W (2012) SLiCE: a novel bacterial cell extract-based DNA cloning method. Nucleic Acids Res 40:1\u201310","journal-title":"Nucleic Acids Res"},{"key":"9688_CR109","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1093\/nar\/18.20.6069","volume":"18","author":"C Aslanidis","year":"1990","unstructured":"Aslanidis C, de Jong PJ (1990) Ligation-independent cloning of PCR products (LIC-PCR). Nucleic Acids Res 18:6069\u20136074","journal-title":"Nucleic Acids Res"},{"key":"9688_CR110","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.chembiol.2004.12.012","volume":"12","author":"SC Wenzel","year":"2005","unstructured":"Wenzel SC, Gross F, Zhang Y, Fu J, Stewart F, M\u00fcller R (2005) Heterologous expression of a myxobacterial natural products assembly line in Pseudomonas via Red\/ET recombineering. Chem Biol 12:349\u2013356","journal-title":"Chem Biol"},{"key":"9688_CR111","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","volume":"6","author":"DG Gibson","year":"2009","unstructured":"Gibson DG, Young L, Chuang RY, Venter JC, Hutchison CA, Smith H (2009) Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods 6:343\u2013345","journal-title":"Nat Methods"},{"key":"9688_CR112","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/protein\/9.11.1055","volume":"9","author":"MK Ramjee","year":"1996","unstructured":"Ramjee MK, Petithory JR, McElver J, Weber SC, Kirsch JF (1996) A novel yeast expression\/secretion system for the recombinant plant thiol endoprotease propapain. Protein Eng 9:1055\u20131061","journal-title":"Protein Eng"},{"key":"9688_CR113","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/nar\/25.2.451","volume":"25","author":"KR Oldenburg","year":"1997","unstructured":"Oldenburg KR, Vo KT, Michaelis S, Paddon C (1997) Recombination-mediated PCR-directed plasmid construction in vivo in yeast. Nucleic Acids Res 25:451\u2013452","journal-title":"Nucleic Acids Res"},{"key":"9688_CR114","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-60761-854-6_2","volume-title":"Computational biology of transcription factor binding, methods in molecular biology,1st ed","author":"A Yilmaz","year":"2010","unstructured":"Yilmaz A, Grotewold E (2010) Components and mechanisms of regulation of gene expression. In: Ladunga I (ed) Computational biology of transcription factor binding, methods in molecular biology,1st ed. Humana Press, Totowa, NJ, pp 23\u201332"},{"key":"9688_CR115","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1046\/j.1365-2958.2002.03100.x","volume":"45","author":"K Heungens","year":"2002","unstructured":"Heungens K, Cowles CE, Goodrich-Blair H (2002) Identification of Xenorhabdus nematophila genes required for mutualistic colonization of Steinernema carpocapsae nematodes. Mol Microbiol 45:1337\u20131353","journal-title":"Mol Microbiol"},{"key":"9688_CR116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1003915","volume":"9","author":"G Jubelin","year":"2013","unstructured":"Jubelin G, Lanois A, Severac D, Rialle S, Longin C, Gaudriault S, Givaudan A (2013) FliZ is a global regulatory protein affecting the expression of flagellar and virulence genes in individual Xenorhabdus nematophila bacterial cells. PLoS Genet 9:1\u201315","journal-title":"PLoS Genet"},{"key":"9688_CR117","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/j.1462-5822.2006.00873.x","volume":"9","author":"KN Cowles","year":"2007","unstructured":"Cowles KN, Cowles CE, Richards GR, Martens EC, Goodrich-Blair H (2007) The global regulator Lrp contributes to mutualism, pathogenesis and phenotypic variation in the bacterium Xenorhabdus nematophila. Cell Microbiol 9:1311\u20131323","journal-title":"Cell Microbiol"},{"key":"9688_CR118","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1875414701003010101","volume":"3","author":"SJ Hinchliffe","year":"2013","unstructured":"Hinchliffe SJ (2013) Insecticidal toxins from the Photorhabdus and Xenorhabdus bacteria. Open Toxinology J 3:101\u2013118","journal-title":"Open Toxinology J"},{"key":"9688_CR119","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/mmi.12500","volume":"91","author":"E Espinosa","year":"2014","unstructured":"Espinosa E, Casades\u00fas J (2014) Regulation of Salmonella enterica pathogenicity island 1 (SPI-1) by the LysR-type regulator LeuO. Mol Microbiol 91:1057\u20131069","journal-title":"Mol Microbiol"},{"key":"9688_CR120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3391\/mbi.2013.4.1.01","volume":"4","author":"XR Bina","year":"2013","unstructured":"Bina XR, Taylor DL, Vikram A, Ante VM, Bine JE (2013) Vibrio cholerae ToxR downregulates virulence factor production in response to cyclo (Phe-pro). MBio 4:1\u20139","journal-title":"MBio"},{"key":"9688_CR121","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1128\/IAI.06284-11","volume":"80","author":"WB Whitaker","year":"2012","unstructured":"Whitaker WB, Parent MA, Boyd A, Richards GP, Boyd F (2012) The Vibrio parahaemolyticus ToxRS regulator is required for stress tolerance and colonization in a novel orogastric streptomycin-induced adult murine model. Infect Immun 80:1834\u20131845","journal-title":"Infect Immun"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-020-09688-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-020-09688-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-020-09688-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T14:01:25Z","timestamp":1723471285000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-020-09688-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":121,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["9688"],"URL":"https:\/\/doi.org\/10.1007\/s12602-020-09688-x","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"type":"print","value":"1867-1306"},{"type":"electronic","value":"1867-1314"}],"subject":[],"published":{"date-parts":[[2020,8,25]]},"assertion":[{"value":"25 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}