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The cell-free supernatants of the two isolates exhibited inhibitory activity towards <jats:italic>Escherichia coli<\/jats:italic> ATCC 25,922 and <jats:italic>Salmonella enterica<\/jats:italic> UC3605, which was ultimately due to the low pH of supernatants. <jats:italic>W. cibaria<\/jats:italic> SP19 showed a co-aggregation ability similar to that of <jats:italic>L. rhamnosus<\/jats:italic> GG when incubated with <jats:italic>S. enterica<\/jats:italic>. Whole genome sequencing and analysis revealed that both strains harbored several genes involved in carbohydrate metabolism and general stress responses, indicating bacterial adaptation to the gastrointestinal environment. We also detected genes involved in the adhesion to host epithelial cells or extracellular matrix. No evidence of acquired antibiotic resistance or hemolytic activity was found in either strain. These findings shed light on the potential of <jats:italic>W. cibaria<\/jats:italic> for probiotic use in livestock and on the mechanisms underlying host-microbe interaction in the gut. <jats:italic>W. cibaria`<\/jats:italic> strain SP19 exhibited the best combination of in vitro probiotic properties and genetic markers, and is a promising candidate for further investigation.<\/jats:p>","DOI":"10.1007\/s12602-020-09715-x","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T07:02:58Z","timestamp":1603263778000},"page":"809-823","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Integrated Phenotypic-Genotypic Analysis of Candidate Probiotic Weissella Cibaria\u00a0Strains Isolated from Dairy Cows in Kuwait"],"prefix":"10.1007","volume":"13","author":[{"given":"Vania","family":"Patrone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahani","family":"Al-Surrayai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Romaniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Sagheddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Puglisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Callegari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamad","family":"Al-Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Waheed","family":"Kishk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"9715_CR1","doi-asserted-by":"publisher","unstructured":"Markowiak P, \u015ali\u017cewska K (2018) The role of probiotics, prebiotics and synbiotics in animal nutrition. 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