{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:53:00Z","timestamp":1790034780795,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12602-021-09753-z","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:50:37Z","timestamp":1613782237000},"page":"655-663","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bacillus Toyonensis BCT-7112T Spores as Parenteral Adjuvant of BoHV-5 Vaccine in a Murine Model"],"prefix":"10.1007","volume":"13","author":[{"given":"Francisco Denis Souza","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Reichert","family":"Maubrigades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria Sequeira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Cabaldi","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Ricardo Centeno","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Casquero","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0941-7286","authenticated-orcid":false,"given":"F\u00e1bio Pereira Leivas","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"issue":"2","key":"9753_CR1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.fm.2010.03.007","volume":"28","author":"SM Cutting","year":"2011","unstructured":"Cutting SM (2011) Bacillus probiotics. Food Microbiol 28(2):214\u2013220. https:\/\/doi.org\/10.1016\/j.fm.2010.03.007","journal-title":"Food Microbiol"},{"issue":"1","key":"9753_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.coi.2009.01.004","volume":"21","author":"BN Lambrecht","year":"2009","unstructured":"Lambrecht BN, Kool M, Willart MA, Hammad H (2009) Mechanism of action of clinically approved adjuvants. Curr Opin Immunol 21(1):23\u201329. https:\/\/doi.org\/10.1016\/j.coi.2009.01.004","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"9753_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.it.2008.09.006","volume":"30","author":"SG Reed","year":"2009","unstructured":"Reed SG, Bertholet S, Coler RN, Friede M (2009) New horizons in adjuvants for vaccine development. Trends Immunol 30(1):23\u201332. https:\/\/doi.org\/10.1016\/j.it.2008.09.006","journal-title":"Trends Immunol"},{"issue":"7","key":"9753_CR4","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1586\/erv.11.48","volume":"10","author":"E Montomoli","year":"2011","unstructured":"Montomoli E, Piccirella S, Khadang B, Mennitto E, Camerini R, De Rosa A (2011) Current adjuvants and new perspectives in vaccine formulation. Expert Rev Vaccines 10(7):1053\u20131061. https:\/\/doi.org\/10.1586\/erv.11.48","journal-title":"Expert Rev Vaccines"},{"key":"9753_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12934-014-0115-2","volume":"13","author":"E Ricca","year":"2014","unstructured":"Ricca E, Baccigalupi L, Cangiano G, Felice M, Isticato R (2014) Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis. Microb Cell Fact 13:1\u20139. https:\/\/doi.org\/10.1186\/s12934-014-0115-2","journal-title":"Microb Cell Fact"},{"issue":"6","key":"9753_CR6","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1002\/eji.200636875","volume":"37","author":"AGC Barnes","year":"2007","unstructured":"Barnes AGC, Cerovic V, Hobson PS, Klavinskis LS (2007) Bacillus subtilis spores: a novel microparticle adjuvant which can instruct a balanced Th1 and Th2 immune response to specific antigen. Eur J Immunol 37(6):1538\u20131547. https:\/\/doi.org\/10.1002\/eji.200636875","journal-title":"Eur J Immunol"},{"issue":"4","key":"9753_CR7","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.vaccine.2009.10.127","volume":"28","author":"J Huang","year":"2010","unstructured":"Huang J, Hong HA, Tong HV, Hoang TH, Brisson A, Cutting SM (2010) Mucosal delivery of antigens using adsorption to bacterial spores. Vaccine 28(4):1021\u20131030. https:\/\/doi.org\/10.1016\/j.vaccine.2009.10.127","journal-title":"Vaccine"},{"issue":"1","key":"9753_CR8","doi-asserted-by":"publisher","first-page":"e87454","DOI":"10.1371\/journal.pone.0087454","volume":"9","author":"RD de Souza","year":"2014","unstructured":"de Souza RD, Batista MT, Luiz WB, Cavalcante RCM, Amorim JH, Bizerra RSP, Martins EG, Ferreira LCS (2014) Bacillus subtilis spores as vaccine adjuvants: further insights into the mechanisms of action. PLoS One 9(1):e87454. https:\/\/doi.org\/10.1371\/journal.pone.0087454","journal-title":"PLoS One"},{"issue":"10","key":"9753_CR9","doi-asserted-by":"publisher","first-page":"4512","DOI":"10.1128\/JCM.41.10.4512-4520.2003","volume":"41","author":"FSF Vogel","year":"2003","unstructured":"Vogel FSF, Caron L, Flores EF, Weiblen R, Winkelmann ER, Mayer SV, Bastos RG (2003) Distribution of bovine herpesvirus type 5 DNA in the central nervous systems of latently, experimentally infected calves. J Clin Microbiol 41(10):4512\u20134520. https:\/\/doi.org\/10.1128\/JCM.41.10.4512-4520.2003","journal-title":"J Clin Microbiol"},{"issue":"1","key":"9753_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.vetmic.2010.08.004","volume":"148","author":"FS Campos","year":"2011","unstructured":"Campos FS, Dezen D, Antunes DA, Santos HF, Arantes TS, Cenci A, Gomes F, Lima FES, Brito WMED, Filho HCK, Batista HBCR, Spilki FR, Franco AC, Rijsewijk FAM, Roehe PM (2011) Efficacy of an inactivated, recombinant bovine herpesvirus type 5 (BoHV-5) vaccine. Vet Microbiol 148(1):18\u201326. https:\/\/doi.org\/10.1016\/j.vetmic.2010.08.004","journal-title":"Vet Microbiol"},{"issue":"1","key":"9753_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13567-014-0111-x","volume":"45","author":"LA Dummer","year":"2014","unstructured":"Dummer LA, Leite FPL, Van Den Hurk SVDL (2014) Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology. Vet Res 45(1):111. https:\/\/doi.org\/10.1186\/s13567-014-0111-x","journal-title":"Vet Res"},{"issue":"1\u20132","key":"9753_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0378-1135(96)01232-1","volume":"53","author":"LA Babiuk","year":"1996","unstructured":"Babiuk LA, Van Drunen Littel-Van Den Hurk S, Tikoo SK (1996) Immunology of bovine herpesvirus 1 infection. Vet Microbiol 53(1\u20132):31\u201342. https:\/\/doi.org\/10.1016\/S0378-1135(96)01232-1","journal-title":"Vet Microbiol"},{"issue":"3\u20134","key":"9753_CR13","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.vetmic.2009.10.016","volume":"142","author":"APM Varela","year":"2010","unstructured":"Varela APM, Holz CL, Cibulski SP, Teixeira TF, Antunes DA, Franco AC, Roehe LR, Oliveira MT, Campos FS, Dezen D, Cenci A, Brito WD, Roehe PM (2010) Neutralizing antibodies to bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) and its subtypes. Vet Microbiol 142(3\u20134):254\u2013260. https:\/\/doi.org\/10.1016\/j.vetmic.2009.10.016","journal-title":"Vet Microbiol"},{"key":"9753_CR14","doi-asserted-by":"publisher","unstructured":"Jim\u00e9nez G, Urdiain M, Cifuentes A, L\u00f3pez-l\u00f3pez A, Blanch AR, Tamames J, K\u00e4mpfer P, Kolst\u00f8 A, Ram\u00f3n D, Rossell\u00f3-m\u00f3ra R, Mart\u00ednez JF, Codo FM (2013) Description of Bacillus toyonensis sp. nov., a novel species of the Bacillus cereus group, and pairwise genome comparisons of the species of the group by means of ANI calculations. Syst Appl Microbiol 36(6):383\u2013391. https:\/\/doi.org\/10.1016\/j.syapm.2013.04.008","DOI":"10.1016\/j.syapm.2013.04.008"},{"issue":"3","key":"9753_CR15","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/jam.12729","volume":"118","author":"D Kantas","year":"2015","unstructured":"Kantas D, Papatsiros VG, Tassis PD, Giavasis I, Bouki P, Tzika ED (2015) A feed additive containing Bacillus toyonensis (Toyocerin\u00ae) protects against enteric pathogens in postweaning piglets. J Appl Microbiol 118(3):727\u2013738. https:\/\/doi.org\/10.1111\/jam.12729","journal-title":"J Appl Microbiol"},{"key":"9753_CR16","doi-asserted-by":"publisher","unstructured":"Williams LD, Burdock GA, Jim\u00e9nez G, Castillo M (2009) Literature review on the safety of Toyocerin, a non-toxigenic and non-pathogenic Bacillus cereus var. toyoi preparation. Regul Toxicol Pharmacol 55(2):236\u2013246. https:\/\/doi.org\/10.1016\/j.yrtph.2009.07.009","DOI":"10.1016\/j.yrtph.2009.07.009"},{"key":"9753_CR17","doi-asserted-by":"publisher","unstructured":"Roos TB, de Lara AP SS, Dummer LA, Fischer G, Leite FPL (2012) The immune modulation of Bacillus cereus var. Toyoi in mice immunized with experimental inactivated Bovine Herpesvirus Type 5 vaccine. Vaccine 30(12):2173\u20132177.\u00a0https:\/\/doi.org\/10.1016\/j.vaccine.2012.01.007","DOI":"10.1016\/j.vaccine.2012.01.007"},{"issue":"1","key":"9753_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3920\/BM2017.0021","volume":"9","author":"FDS Santos","year":"2018","unstructured":"Santos FDS, Menegon YA, Piraine REA, Rodrigues PRC, Cunha RC, Leite FPL (2018) Bacillus toyonensis improves immune response in the mice vaccinated with recombinant antigen of bovine herpesvirus type 5. Benef Microbes 9(1):133\u2013142. https:\/\/doi.org\/10.3920\/BM2017.0021","journal-title":"Benef Microbes"},{"issue":"1","key":"9753_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12934-020-01308-1","volume":"19","author":"FDS Santos","year":"2020","unstructured":"Santos FDS, Mazzoli A, Maia AR, Saggese A, Isticato R, Leite F, Iossa S, Ricca E, Baccigalupi L (2020) A probiotic treatment increases the immune response induced by the nasal delivery of spore-adsorbed TTFC. Microb Cell Fact 19(1):42. https:\/\/doi.org\/10.1186\/s12934-020-01308-1","journal-title":"Microb Cell Fact"},{"key":"9753_CR20","first-page":"315","volume":"3","author":"AA Yousten","year":"1984","unstructured":"Yousten AA (1984) Bacillus sphaericus: microbiological factors related to its potential as a mosquito larvicide. Adv Biotechnol Processes 3:315\u2013343","journal-title":"Adv Biotechnol Processes"},{"issue":"3","key":"9753_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00284-012-0269-2","volume":"66","author":"MB Tavares","year":"2013","unstructured":"Tavares MB, de Souza RD, Luiz WB, Cavalcante RCM, Casaroli C, Martins EG, Ferreira RCC, Ferreira LCS (2013) Bacillus subtilis endospores at high purity and recovery yields: optimization of growth conditions and purification method. Curr Microbiol 66(3):279\u2013285. https:\/\/doi.org\/10.1007\/s00284-012-0269-2","journal-title":"Curr Microbiol"},{"issue":"1","key":"9753_CR22","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jviromet.2009.05.022","volume":"161","author":"LA Dummer","year":"2009","unstructured":"Dummer LA, Concei\u00e7\u00e3o FR, Nizoli LQ, de Moraes CM, Rocha AR, de Souza LL, Roos T, Vidor T, Leite FPL (2009) Cloning and expression of a truncated form of envelope glycoprotein D of bovine herpesvirus type 5 in methylotrophic yeast Pichia pastoris. J Virol Methods 161(1):84\u201390. https:\/\/doi.org\/10.1016\/j.jviromet.2009.05.022","journal-title":"J Virol Methods"},{"issue":"21","key":"9753_CR23","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1016\/j.vaccine.2014.03.011","volume":"32","author":"LA Dummer","year":"2014","unstructured":"Dummer LA, Araujo IL, Finger PF, dos Santos AG, da Rosa MC, Concei\u00e7\u00e3o FR, Fischer G, van Drunen Littel-van den Hurk S, Leite FPL (2014) Immune responses of mice against recombinant bovine herpesvirus 5 glycoprotein D. Vaccine 32(21):2413\u20132419. https:\/\/doi.org\/10.1016\/j.vaccine.2014.03.011","journal-title":"Vaccine"},{"issue":"7","key":"9753_CR24","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.vaccine.2006.10.005","volume":"25","author":"G Fischer","year":"2007","unstructured":"Fischer G, Concei\u00e7\u00e3o FR, Leite FPL, Dummer LA, Vargas GDA, H\u00fcbner SO, Dellagostin OA, Paulino N, Paulino AS, Vidor T (2007) Immunomodulation produced by a green propolis extract on humoral and cellular responses of mice immunized with SuHV-1. Vaccine 25(7):1250\u20131256. https:\/\/doi.org\/10.1016\/j.vaccine.2006.10.005","journal-title":"Vaccine"},{"issue":"10","key":"9753_CR25","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1128\/IAI.71.10.5845-5854.2003","volume":"71","author":"PJ Cardona","year":"2003","unstructured":"Cardona PJ, Gordillo S, D\u00edaz J, Tapia G, Amat I, Pallar\u00e9s \u00c1, Vilaplana C, Ariza A, Ausina V (2003) Widespread bronchogenic dissemination makes DBA\/2 mice more susceptible than C57BL\/6 mice to experimental aerosol infection with Mycobacterium tuberculosis. Infect Immun 71(10):5845\u20135854. https:\/\/doi.org\/10.1128\/IAI.71.10.5845-5854.2003","journal-title":"Infect Immun"},{"key":"9753_CR26","doi-asserted-by":"publisher","unstructured":"Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele JWC (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55(4):611\u2013622. https:\/\/doi.org\/10.1373\/clinchem.2008.112797","DOI":"10.1373\/clinchem.2008.112797"},{"issue":"4","key":"9753_CR27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"9753_CR28","doi-asserted-by":"publisher","unstructured":"Schierack P, Wieler LH, Taras D, Herwig V, Tachu B, Hlinak A, Schmidt MFG, Scharek L (2007) Bacillus cereus var. toyoi enhanced systemic immune response in piglets. Vet Immunol Immunopathol 118(1\u22122):1\u221211.\u00a0https:\/\/doi.org\/10.1016\/j.vetimm.2007.03.006","DOI":"10.1016\/j.vetimm.2007.03.006"},{"issue":"13","key":"9753_CR29","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1084\/jem.20061884","volume":"203","author":"M Chieppa","year":"2006","unstructured":"Chieppa M, Rescigno M, Huang AYC, Germain RN (2006) Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 203(13):2841\u20132852. https:\/\/doi.org\/10.1084\/jem.20061884","journal-title":"J Exp Med"},{"issue":"5","key":"9753_CR30","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1128\/IAI.71.5.2810-2818.2003","volume":"71","author":"LH Duc","year":"2003","unstructured":"Duc LH, Hong HA, Fairweather N, Ricca E, Cutting SM (2003) Bacterial spores as vaccine vehicles. Infect Immun 71(5):2810\u20132818. https:\/\/doi.org\/10.1128\/IAI.71.5.2810-2818.2003","journal-title":"Infect Immun"},{"key":"9753_CR31","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nrmicro2297","volume":"8","author":"S Lebeer","year":"2010","unstructured":"Lebeer S, Vanderleyden J, Keersmaecker SCJ (2010) Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol 8:171\u2013184. https:\/\/doi.org\/10.1038\/nrmicro2297","journal-title":"Nat Rev Microbiol"},{"key":"9753_CR32","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.femsre.2004.12.001","volume":"29","author":"HA Hong","year":"2005","unstructured":"Hong HA, Duc LH, Cutting SM (2005) The use of bacterial spore formers as probiotics. FEMS Microbiol Rev 29:813\u2013835. https:\/\/doi.org\/10.1016\/j.femsre.2004.12.001","journal-title":"FEMS Microbiol Rev"},{"key":"9753_CR33","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1016\/j.vaccine.2015.03.043","volume":"33","author":"LRMM Aps","year":"2015","unstructured":"Aps LRMM, Diniz MO, Porchia BFMM, Sales NS, Moreno ACR, Ferreira LCS (2015) Bacillus subtilis spores as adjuvants for DNA vaccines. Vaccine 33:2328\u20132334. https:\/\/doi.org\/10.1016\/j.vaccine.2015.03.043","journal-title":"Vaccine"},{"key":"9753_CR34","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.4049\/jimmunol.0802318","volume":"182","author":"V Cerovic","year":"2009","unstructured":"Cerovic V, Jenkins CD, Barnes AGC, Milling SWF, MacPherson GG, Klavinskis LS (2009) Hyporesponsiveness of intestinal dendritic cells to TLR stimulation is limited to TLR4. J Immunol 182:2405\u20132415. https:\/\/doi.org\/10.4049\/jimmunol.0802318","journal-title":"J Immunol"},{"key":"9753_CR35","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/j.1348-0421.2012.00508.x","volume":"56","author":"X Xu","year":"2012","unstructured":"Xu X, Huang Q, Mao Y, Cui Z, Li Y, Huang Y, Rajput IR, Yu D, Li W (2012) Immunomodulatory effects of Bacillus subtilis (natto) B4 spores on murine macrophages. Microbiol Immunol 56:817\u2013824. https:\/\/doi.org\/10.1111\/j.1348-0421.2012.00508.x","journal-title":"Microbiol Immunol"},{"key":"9753_CR36","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","volume":"32","author":"S Gordon","year":"2010","unstructured":"Gordon S, Martinez FO (2010) Alternative activation of macrophages: mechanism and functions. Immunity 32:593\u2013604. https:\/\/doi.org\/10.1016\/j.immuni.2010.05.007","journal-title":"Immunity"},{"key":"9753_CR37","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1126\/science.1204351","volume":"332","author":"SJ Jenkins","year":"2011","unstructured":"Jenkins SJ, Ruckerl D, Cook PC, Jones LH, Finkelman FD, van Rooijen N, MacDonald AS, Allen JE (2011) Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 332:1284\u20131288. https:\/\/doi.org\/10.1126\/science.1204351","journal-title":"Science"},{"key":"9753_CR38","doi-asserted-by":"publisher","first-page":"221","DOI":"10.4049\/jimmunol.167.1.221","volume":"167","author":"U Grohmann","year":"2001","unstructured":"Grohmann U, Belladonna ML, Vacca C, Bianchi R, Fallarino F, Orabona C, Fioretti MC, Puccetti P (2001) Positive regulatory role of IL-12 in macrophages and modulation by IFN-\u03b3. J Immunol 167:221\u2013227. https:\/\/doi.org\/10.4049\/jimmunol.167.1.221","journal-title":"J Immunol"},{"key":"9753_CR39","unstructured":"United States Department of Agriculture (USDA) (2005) Animal and Plant Health Inspection Service. pp. 683\u2013684"},{"key":"9753_CR40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1084\/jem.165.1.64","volume":"165","author":"JT Coutelier","year":"1987","unstructured":"Coutelier JT, Van der Logt JTM, Heessen FW, Warnier G, Van Snick J (1987) IgG2a restriction of murine antibodies elicited by viral infections. J Exp Med 165:64\u201369","journal-title":"J Exp Med"},{"key":"9753_CR41","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1128\/JVI.76.1.432-435.2002","volume":"76","author":"D Markine-Goriaynoff","year":"2002","unstructured":"Markine-Goriaynoff D, Coutelier JP (2002) Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants. J Virol 76:432\u2013435. https:\/\/doi.org\/10.1128\/JVI.76.1.432-435.2002","journal-title":"J Virol"},{"issue":"2014","key":"9753_CR42","doi-asserted-by":"publisher","first-page":"157895","DOI":"10.1155\/2014\/157895","volume":"2014","author":"PJ Klasse","year":"2014","unstructured":"Klasse PJ (2014) Neutralization of virus infectivity by antibodies\u202f: old problems in new perspectives. Adv Biol 2014(2014):157895. https:\/\/doi.org\/10.1155\/2014\/157895","journal-title":"Adv Biol"},{"key":"9753_CR43","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.4049\/jimmunol.171.8.4187","volume":"171","author":"M Giroux","year":"2003","unstructured":"Giroux M, Schmidt M, Descoteaux A (2003) IFN-\u03b3-induced MHC class II expression: transactivation of class II transactivator promoter IV by IFN regulatory factor-1 is regulated by protein kinase C-\u03b1. J Immunol 171:4187\u20134194. https:\/\/doi.org\/10.4049\/jimmunol.171.8.4187","journal-title":"J Immunol"},{"key":"9753_CR44","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nri1001","volume":"3","author":"G Trinchieri","year":"2003","unstructured":"Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133\u2013146. https:\/\/doi.org\/10.1038\/nri1001","journal-title":"Nat Rev Immunol"},{"key":"9753_CR45","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev.iy.08.040190.001511","volume":"8","author":"FD Finkelman","year":"1990","unstructured":"Finkelman FD, Holmes J, Katona IM, Urban JF, Beckmann MP, Park LS, Schooley KA, Coffman RL, Mosmann TR, Paul WE (1990) Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 8:303\u2013333. https:\/\/doi.org\/10.1146\/annurev.iy.08.040190.001511","journal-title":"Annu Rev Immunol"},{"key":"9753_CR46","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nri2735","volume":"28","author":"WE Paul","year":"2010","unstructured":"Paul WE, Zhu J, Yamane H (2010) Determination of effector CD4 T cell populations. Annu Rev Immunol 28:445\u2013489. https:\/\/doi.org\/10.1038\/nri2735","journal-title":"Annu Rev Immunol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-021-09753-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-021-09753-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-021-09753-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T07:15:06Z","timestamp":1623654906000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-021-09753-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["9753"],"URL":"https:\/\/doi.org\/10.1007\/s12602-021-09753-z","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,19]]},"assertion":[{"value":"1 February 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Mice used in this study were provided by the animal unit at Federal University of Pelotas (UFPel). All protocols and procedures were reviewed and approved by the Ethics Committee on Animal Experimentation (CEEA No. 1981) of the UFPel. The CEEA of UFPel is accredited by the Brazilian National Council for the Control of Animal Experimentation (CONCEA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All authors of this paper have approved the submission of this manuscript. The contents of this manuscript have not been copyrighted or published previously.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"The authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}