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We aimed to confirm whether<jats:italic>A. faecalis<\/jats:italic>A12C is safe and has adequate intestinal colonization in experimental rats, and evaluate its efficacy in an animal model of peritonitis<jats:italic>.<\/jats:italic>We used 30 male rats, randomly divided into 6 groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a05): three groups (HA7, HA15, HA30) received<jats:italic>A. faecalis<\/jats:italic>A12C in drinking water (6\u00a0\u00d7\u00a010<jats:sup>8<\/jats:sup>\u00a0CFU\/mL) for 7\u00a0days, and three control groups received drinking water only. All groups were evaluated at 7, 15, and 30\u00a0days. Survival after<jats:italic>A. faecalis<\/jats:italic>A12C administration was 100% in all groups. Mild eosinophilia (1.5%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and increased aspartate aminotransferase (86\u00a0IU\/L,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) were observed in HA7, followed by progressive normalization. No histological signs of organ injury were found. We observed significant<jats:italic>E. coli<\/jats:italic>decline in faeces, parallel to an increase in<jats:italic>A. faecalis<\/jats:italic>A12C at 7\u00a0days.<jats:italic>E. coli<\/jats:italic>had a tendency to recover initial values, while<jats:italic>A. faecalis<\/jats:italic>A12C disappeared from the intestinal microbiota at 30\u00a0days. To evaluate its efficacy against peritonitis, we studied two additional groups of animals: IA group pretreated with<jats:italic>A. faecalis<\/jats:italic>A12C before<jats:italic>E. coli<\/jats:italic>intra-abdominal inoculation, and IC group inoculated with no<jats:italic>A. faecalis<\/jats:italic>A12C. We found an increase in C-reactive protein, alanine aminotransferase, urea, and eosinophils in IC animals when compared with IA. Peritonitis was more evident in IC than in IA animals. Our findings suggest that<jats:italic>A. faecalis<\/jats:italic>A12C altered clinically relevant parameters in sepsis and was associated with a lesser spread of infection.<\/jats:p>","DOI":"10.1007\/s12602-021-09767-7","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T13:02:50Z","timestamp":1615640570000},"page":"1326-1337","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Probiotic Properties of Alcaligenes faecalis Isolated from Argyrosomus regius in Experimental Peritonitis\u00a0(Rat Model)"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2672-9356","authenticated-orcid":false,"given":"A. I.","family":"Guti\u00e9rrez-Falc\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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