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In addition, the charcoal meal test showed that <jats:italic>L. plantarum<\/jats:italic> PS128 significantly increased the small intestine transit in na\u00efve mice, but not in the Lop-treated mice. Since intestinal serotonin has been found to modulate motility, we further analyzed the expression of genes related to serotonin signal transduction in the small intestine of na\u00efve mice. The results showed that <jats:italic>L. plantarum<\/jats:italic> PS128 significantly altered the expression levels of <jats:italic>Tph1<\/jats:italic>, <jats:italic>Chga<\/jats:italic>, <jats:italic>Slc6a4<\/jats:italic>, and <jats:italic>Htr4<\/jats:italic>, but did not affect the expression levels of <jats:italic>Tph2<\/jats:italic>, <jats:italic>Htr3a<\/jats:italic>, and <jats:italic>Maoa<\/jats:italic>. Furthermore, immunohistochemistry revealed that <jats:italic>L. plantarum<\/jats:italic> PS128 significantly increased the number of serotonin-containing intestinal cells in mice. Taken together, our results suggest that <jats:italic>L. plantarum<\/jats:italic> PS128 could promote intestinal motility, mucin production, and serotonin signal transduction, leading to a laxative effect in mice.<\/jats:p>","DOI":"10.1007\/s12602-021-09814-3","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T22:02:26Z","timestamp":1627596146000},"page":"535-545","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice"],"prefix":"10.1007","volume":"14","author":[{"given":"Chih-Ming","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-4742","authenticated-orcid":false,"given":"Ying-Chieh","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"9814_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03873","volume-title":"Guidelines for the evaluation of probiotics in food","author":"FAO, WHO,","year":"2002","unstructured":"FAO\/WHO (2002) Guidelines for the evaluation of probiotics in food. 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