{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:27:40Z","timestamp":1782368860617,"version":"3.54.5"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s12602-022-09964-y","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T05:02:40Z","timestamp":1657083760000},"page":"149-159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Early-Life Intervention of Lactoferrin and Probiotic in Suckling Piglets: Effects on Immunoglobulins, Intestinal Integrity, and Neonatal Mortality"],"prefix":"10.1007","volume":"15","author":[{"given":"Varun Kumar","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-4726","authenticated-orcid":false,"given":"Ujjwal Kumar","family":"De","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Kala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babul Rudra","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srishti","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra Singh","family":"Gandhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas Kumar","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethan Gollahalli","family":"Eregowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanendra Kumar","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"9964_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.animal.2021.100352","volume":"15","author":"E Sell-Kubiak","year":"2021","unstructured":"Sell-Kubiak E (2021) Selection for litter size and litter birthweight in Large White pigs: maximum, mean and variability of reproduction traits. Animal 15:100352. https:\/\/doi.org\/10.1016\/j.animal.2021.100352","journal-title":"Animal"},{"key":"9964_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2049-1891-3-42","volume":"3","author":"RA Cabrera","year":"2012","unstructured":"Cabrera RA, Lin X, Campbell JM, Moeser AJ, Odle J (2012) Influence of birth order, birth weight, colostrum and serum immunoglobulin G on neonatal piglet survival. J Anim Sci Biotechnol 3:1\u201310. https:\/\/doi.org\/10.1186\/2049-1891-3-42","journal-title":"J Anim Sci Biotechnol"},{"key":"9964_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.dci.2008.06.015","volume":"33","author":"JE Butler","year":"2009","unstructured":"Butler JE, Zhao Y, Sinkora M, Wertz N, Kacskovics I (2009) Immunoglobulins, antibody repertoire and B cell development. Dev Comp Immunol 33:321\u2013333. https:\/\/doi.org\/10.1016\/j.dci.2008.06.015","journal-title":"Dev Comp Immunol"},{"key":"9964_CR4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.dci.2008.07.007","volume":"33","author":"H Salmon","year":"2009","unstructured":"Salmon H, Berri M, Gerdts V, Meurens F (2009) Humoral and cellular factors of maternal immunity in swine. Dev Comp Immunol 33:384\u2013393. https:\/\/doi.org\/10.1016\/j.dci.2008.07.007","journal-title":"Dev Comp Immunol"},{"key":"9964_CR5","doi-asserted-by":"publisher","first-page":"442","DOI":"10.3390\/nu3040442","volume":"3","author":"WL Hurley","year":"2011","unstructured":"Hurley WL, Theil PK (2011) Perspectives on immunoglobulins in colostrum and milk. Nutrients 3:442\u2013474. https:\/\/doi.org\/10.3390\/nu3040442","journal-title":"Nutrients"},{"key":"9964_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fvets.2021.574250","volume":"8","author":"E Navarro","year":"2021","unstructured":"Navarro E, Mainau E, de Miguel R, Temple D, Salas M, Manteca X (2021) Oral meloxicam administration in sows at farrowing and its effects on piglet immunity transfer and growth. Front Vet Sci 8:72. https:\/\/doi.org\/10.3389\/fvets.2021.574250","journal-title":"Front Vet Sci"},{"key":"9964_CR7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000354907","volume":"63","author":"WA Walker","year":"2013","unstructured":"Walker WA (2013) Initial intestinal colonization in the human infant and immune homeostasis. Ann Nutr Metab 63:8\u201315. https:\/\/doi.org\/10.1159\/000354907","journal-title":"Ann Nutr Metab"},{"key":"9964_CR8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1017\/S1466252312000084","volume":"13","author":"R Isaacson","year":"2012","unstructured":"Isaacson R, Kim HB (2012) The intestinal microbiome of the pig. Anim Health Res Rev 13:100. https:\/\/doi.org\/10.1017\/S1466252312000084","journal-title":"Anim Health Res Rev"},{"key":"9964_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2323\/jgam.60.140","volume":"60","author":"EA Pajarillo","year":"2014","unstructured":"Pajarillo EA, Chae JP, Balolong MP, Kim HB, Kang DK (2014) Assessment of fecal bacterial diversity among healthy piglets during the weaning transition. J Gen Appl Microbiol 60:140\u2013146. https:\/\/doi.org\/10.2323\/jgam.60.140","journal-title":"J Gen Appl Microbiol"},{"key":"9964_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.anaerobe.2017.12.002","volume":"49","author":"X Chen","year":"2018","unstructured":"Chen X, Xu J, Ren E, Su Y, Zhu W (2018) Co-occurrence of early gut colonization in neonatal piglets with microbiota in the maternal and surrounding delivery environments. Anaerobe 49:30\u201340. https:\/\/doi.org\/10.1016\/j.anaerobe.2017.12.002","journal-title":"Anaerobe"},{"key":"9964_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2017.9","volume":"6","author":"D Bauche","year":"2017","unstructured":"Bauche D, Marie JC (2017) Transforming growth factor \u03b2: a master regulator of the gut microbiota and immune cell interactions. Clin Transl Immunol 6:e136. https:\/\/doi.org\/10.1038\/cti.2017.9","journal-title":"Clin Transl Immunol"},{"key":"9964_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/biom11010017","volume":"11","author":"C Stolfi","year":"2021","unstructured":"Stolfi C, Troncone E, Marafini I, Monteleone G (2021) Role of TGF-beta and Smad7 in gut inflammation, fibrosis and cancer. Biomolecules 11:17. https:\/\/doi.org\/10.3390\/biom11010017","journal-title":"Biomolecules"},{"key":"9964_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1079\/BJN20041302","volume":"93","author":"J Mei","year":"2005","unstructured":"Mei J, Xu RJ (2005) Transient changes of transforming growth factor-\u03b2 expression in the small intestine of the pig in association with weaning. Br J Nutr 93:37\u201345. https:\/\/doi.org\/10.1079\/BJN20041302","journal-title":"Br J Nutr"},{"key":"9964_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/antibiotics9010035","volume":"9","author":"R Xu","year":"2020","unstructured":"Xu R, Wan J, Lin C, Su Y (2020) Effects of early intervention with antibiotics and maternal faecal microbiota on transcriptomic profiling ileal mucosa in neonatal pigs. Antibiotics 9:35. https:\/\/doi.org\/10.3390\/antibiotics9010035","journal-title":"Antibiotics"},{"key":"9964_CR15","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1111\/1462-2920.13272","volume":"18","author":"G Bian","year":"2016","unstructured":"Bian G, Ma S, Zhu Z, Su Y, Zoetendal EG, Mackie R, Liu J, Mu C, Huang R, Smidt H, Zhu W (2016) Age, introduction of solid feed and weaning are more important determinants of gut bacterial succession in piglets than breed and nursing mother as revealed by a reciprocal cross-fostering model. Environ Microbiol 18:1566\u20131577. https:\/\/doi.org\/10.1111\/1462-2920.13272","journal-title":"Environ Microbiol"},{"key":"9964_CR16","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1111\/1751-7915.12370","volume":"9","author":"JP Chae","year":"2016","unstructured":"Chae JP, Pajarillo EA, Oh JK, Kim H, Kang DK (2016) Revealing the combined effects of lactulose and probiotic enterococci on the swine faecal microbiota using 454 pyrosequencing. Microb Biotechnol 9:486\u2013495. https:\/\/doi.org\/10.1111\/1751-7915.12370","journal-title":"Microb Biotechnol"},{"key":"9964_CR17","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3389\/fimmu.2020.00903","volume":"11","author":"Q Hu","year":"2020","unstructured":"Hu Q, Liu C, Zhang D, Wang R, Qin L, Xu Q, Che L, Gao F (2020) Effects of low-dose antibiotics on gut immunity and antibiotic resistomes in weaned piglets. Front Immunol 11:903. https:\/\/doi.org\/10.3389\/fimmu.2020.00903","journal-title":"Front Immunol"},{"key":"9964_CR18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10534-010-9335-z","volume":"23","author":"R Paesano","year":"2010","unstructured":"Paesano R, Berlutti F, Pietropaoli M, Pantanella F, Pacifici E, Goolsbee W, Valenti P (2010) Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. Biometals 23:411\u2013417. https:\/\/doi.org\/10.1007\/s10534-010-9335-z","journal-title":"Biometals"},{"key":"9964_CR19","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3945\/jn.113.190264","volume":"144","author":"SS Comstock","year":"2014","unstructured":"Comstock SS, Reznikov EA, Contractor N, Donovan SM (2014) Dietary bovine lactoferrin alters mucosal and systemic immune cell responses in neonatal piglets. J Nutr 144:525\u2013532. https:\/\/doi.org\/10.3945\/jn.113.190264","journal-title":"J Nutr"},{"key":"9964_CR20","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/jsfa.9214","volume":"99","author":"HA Elbarbary","year":"2019","unstructured":"Elbarbary HA, Ejima A, Sato K (2019) Generation of antibacterial peptides from crude cheese whey using pepsin and rennet enzymes at various pH conditions. J Sci Food Agric 99:555\u2013563. https:\/\/doi.org\/10.1002\/jsfa.9214","journal-title":"J Sci Food Agric"},{"key":"9964_CR21","doi-asserted-by":"publisher","unstructured":"Donker\u00a0AE, van der Staaij\u00a0H, Swinkels DW (2021) The critical roles of iron during the journey from fetus to adolescent: developmental aspects of iron homeostasis. Blood Rev 50:100866. https:\/\/doi.org\/10.1016\/j.blre.2021.100866","DOI":"10.1016\/j.blre.2021.100866"},{"key":"9964_CR22","doi-asserted-by":"publisher","unstructured":"Zhao X, Zhang X, Xu T, Luo J, Luo Y, An P (2022) Comparative effects between oral lactoferrin and ferrous sulfate supplementation on iron-deficiency anemia: a comprehensive review and meta-analysis of clinical trials. Nutrients 14:543. https:\/\/doi.org\/10.3390\/nu14030543","DOI":"10.3390\/nu14030543"},{"key":"9964_CR23","doi-asserted-by":"publisher","unstructured":"Majka G, \u015apiewak K, Kurpiewska K, Heczko P, Stochel G, Strus M, Brindell MA (2013) A high-throughput method for the quantification of iron saturation in lactoferrin preparations. Anal Bioanal Chem 405:5191\u2013200. https:\/\/doi.org\/10.1007\/s00216-013-6943-9","DOI":"10.1007\/s00216-013-6943-9"},{"key":"9964_CR24","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1159\/000244182","volume":"67","author":"S Oguchi","year":"1995","unstructured":"Oguchi S, Walker WA, Sanderson IR (1995) Iron saturation alters the effect of lactoferrin on the proliferation and differentiation of human enterocytes (Caco-2 cells). Biol Neonate 67:330\u2013339. https:\/\/doi.org\/10.1159\/000244182","journal-title":"Biol Neonate"},{"key":"9964_CR25","doi-asserted-by":"publisher","unstructured":"Vega-Bautista A, de la Garza M, Carrero JC, Campos-Rodr\u00edguez R, God\u00ednez-Victoria M, Drago-Serrano ME (2019) The impact of lactoferrin on the growth of intestinal inhabitant bacteria. Int J Mol Sci 20:4707. https:\/\/doi.org\/10.3390\/ijms20194707","DOI":"10.3390\/ijms20194707"},{"key":"9964_CR26","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1139\/o2012-003","volume":"90","author":"W Hu","year":"2012","unstructured":"Hu W, Zhao J, Wang J, Yu T, Wang J, Li N (2012) Transgenic milk containing recombinant human lactoferrin modulates the intestinal flora in piglets. Biochem Cell Biol 90:485\u2013496. https:\/\/doi.org\/10.1139\/o2012-003","journal-title":"Biochem Cell Biol"},{"key":"9964_CR27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/nyas.13405","volume":"1405","author":"NA Hering","year":"2017","unstructured":"Hering NA, Luettig J, Krug SM, Wiegand S, Gross G, van Tol EA, Schulzke JD, Rosenthal R (2017) Lactoferrin protects against intestinal inflammation and bacteria-induced barrier dysfunction in vitro. Ann N Y Acad Sci 1405:177\u2013188. https:\/\/doi.org\/10.1111\/nyas.13405","journal-title":"Ann N Y Acad Sci"},{"key":"9964_CR28","doi-asserted-by":"publisher","first-page":"G851","DOI":"10.1152\/ajpgi.00327.2009","volume":"298","author":"J Karczewski","year":"2010","unstructured":"Karczewski J, Troost FJ, Konings I, Dekker J, Kleerebezem M, Brummer RJM, Wells JM (2010) Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol Gastrointest Liver Physiol 298:G851\u2013G859. https:\/\/doi.org\/10.1152\/ajpgi.00327.2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9964_CR29","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3390\/nu3010104","volume":"3","author":"S Ahrne","year":"2011","unstructured":"Ahrne S, Hagslatt ML (2011) Effect of lactobacilli on paracellular permeability in the gut. Nutrients 3:104\u2013117. https:\/\/doi.org\/10.3390\/nu3010104","journal-title":"Nutrients"},{"key":"9964_CR30","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.2527\/jas.2007-0603","volume":"86","author":"ME Davis","year":"2008","unstructured":"Davis ME, Parrott T, Brown DC, De Rodas BZ, Johnson ZB, Maxwell CV, Rehberger T (2008) Effect of a Bacillus-based direct-fed microbial feed supplement on growth performance and pen cleaning characteristics of growing-finishing pigs. J Anim Sci 86:1459\u20131467. https:\/\/doi.org\/10.2527\/jas.2007-0603","journal-title":"J Anim Sci"},{"key":"9964_CR31","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1111\/j.1365-2672.2009.04294.x","volume":"107","author":"AN Wang","year":"2009","unstructured":"Wang AN, Yi XW, Yu HF, Dong B, Qiao SY (2009) Free radical scavenging activity of Lactobacillus fermentum in vitro and its antioxidative effect on growing\u2013finishing pigs. J Appl Microbiol 107:1140\u20131148. https:\/\/doi.org\/10.1111\/j.1365-2672.2009.04294.x","journal-title":"J Appl Microbiol"},{"key":"9964_CR32","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1128\/CVI.00406-06","volume":"14","author":"CM Galdeano","year":"2007","unstructured":"Galdeano CM, De Leblanc ADM, Vinderola G, Bonet MB, Perdigon G (2007) Proposed model: mechanisms of immunomodulation induced by probiotic bacteria. Clin Vaccine Immunol 14:485\u2013492. https:\/\/doi.org\/10.1128\/CVI.00406-06","journal-title":"Clin Vaccine Immunol"},{"key":"9964_CR33","doi-asserted-by":"publisher","first-page":"451","DOI":"10.5958\/0974-181X.2016.00042.1","volume":"16","author":"R Dowarah","year":"2016","unstructured":"Dowarah R, Verma AK, Agarwal N, Singh P (2016) Effect of swine-based probiotic on growth performance, nutrient utilization and immune status of early weaned grower-finisher crossbred pigs. Anim Nutr Feed Technol 16:451\u2013461. https:\/\/doi.org\/10.5958\/0974-181X.2016.00042.1","journal-title":"Anim Nutr Feed Technol"},{"key":"9964_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192978","volume":"13","author":"R Dowarah","year":"2018","unstructured":"Dowarah R, Verma AK, Agarwal N, Singh P, Singh BR (2018) Selection and characterization of probiotic lactic acid bacteria and its impact on growth, nutrient digestibility, health and antioxidant status in weaned piglets. PLoS ONE 13:e0192978. https:\/\/doi.org\/10.1371\/journal.pone.0192978","journal-title":"PLoS ONE"},{"key":"9964_CR35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.livsci.2016.11.006","volume":"195","author":"R Dowarah","year":"2017","unstructured":"Dowarah R, Verma AK, Agarwal N, Patel BHM, Singh P (2017) Effect of swine-based probiotic on performance, diarrhoea scores, intestinal microbiota and gut health of grower-finisher crossbred pigs. Livest Sci 195:74\u201379. https:\/\/doi.org\/10.1016\/j.livsci.2016.11.006","journal-title":"Livest Sci"},{"key":"9964_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103591","volume":"63","author":"Y Li","year":"2019","unstructured":"Li Y, Hou S, Chen J, Peng W, Wen W, Chen F, Huang X (2019) Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets. J Func Food 63:103591. https:\/\/doi.org\/10.1016\/j.jff.2019.103591","journal-title":"J Func Food"},{"key":"9964_CR37","doi-asserted-by":"publisher","first-page":"6919803","DOI":"10.1155\/2019\/6919803","volume":"2019","author":"Y Li","year":"2019","unstructured":"Li Y, Hou S, Peng W, Lin Q, Chen F, Yang L, Li F, Huang X (2019) Oral administration of Lactobacillus delbrueckii during the suckling phase improves antioxidant activities and immune responses after the weaning event in a piglet model. Oxid Med Cell Longev 2019:6919803. https:\/\/doi.org\/10.1155\/2019\/6919803","journal-title":"Oxid Med Cell Longev"},{"key":"9964_CR38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/2049-1891-4-35","volume":"4","author":"PA Thacker","year":"2013","unstructured":"Thacker PA (2013) Alternatives to antibiotics as growth promoters for use in swine production: a review. J Anim Sci Biotechnol 4:35. https:\/\/doi.org\/10.1186\/2049-1891-4-35","journal-title":"J Anim Sci Biotechnol"},{"key":"9964_CR39","doi-asserted-by":"crossref","unstructured":"Muurinen J, Richert J, Wickware CL, Richert B, Johnson TA (2021) Swine growth promotion with antibiotics or alternatives can increase antibiotic resistance gene mobility potential. Sci Rep 11:1\u20133. https:\/\/github.com\/sjmuurine\/ZnCu","DOI":"10.1038\/s41598-021-84759-9"},{"key":"9964_CR40","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/apa.13270","volume":"105","author":"Y Vandenplas","year":"2016","unstructured":"Vandenplas Y, Benninga M, Broekaert I, Falconer J, Gottrand F, Guarino A, Lifschitz C, Lionetti P, Orel R, Papadopoulou A (2016) Functional gastro-intestinal disorder algorithms focus on early recognition, parental reassurance and nutritional strategies. Acta Paediatr 105:244\u2013252. https:\/\/doi.org\/10.1111\/apa.13270","journal-title":"Acta Paediatr"},{"key":"9964_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-019-1991-9","volume":"15","author":"S Wang","year":"2019","unstructured":"Wang S, Yao B, Gao H, Zang J, Tao S, Zhang S, Huang S, He B, Wang J (2019) Combined supplementation of Lactobacillus fermentum and Pediococcus acidilactici promoted growth performance, alleviated inflammation, and modulated intestinal microbiota in weaned pigs. BMC Vet Res 15:1\u201311. https:\/\/doi.org\/10.1186\/s12917-019-1991-9","journal-title":"BMC Vet Res"},{"key":"9964_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-91427-5","volume":"11","author":"P Pupa","year":"2021","unstructured":"Pupa P, Apiwatsiri P, Sirichokchatchawan W, Pirarat N, Maison T, Koontanatechanon A, Prapasarakul N (2021) Use of Lactobacillus plantarum (strains 22F and 25F) and Pediococcus acidilactici (strain 72N) as replacements for antibiotic-growth promotants in pigs. Sci Rep 11:1\u201312. https:\/\/doi.org\/10.1038\/s41598-021-91427-5","journal-title":"Sci Rep"},{"key":"9964_CR43","doi-asserted-by":"publisher","first-page":"5276","DOI":"10.3168\/jds.2007-0361","volume":"90","author":"EA English","year":"2007","unstructured":"English EA, Hopkins BA, Stroud JS, Davidson S, Smith G, Brownie C, Whitlow LW (2007) Lactoferrin supplementation to Holstein calves during the preweaning and postweaning phases. J Dairy Sci 90:5276\u20135281. https:\/\/doi.org\/10.3168\/jds.2007-0361","journal-title":"J Dairy Sci"},{"key":"9964_CR44","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1080\/00071668.2011.607429","volume":"52","author":"MS Geier","year":"2011","unstructured":"Geier MS, Torok VA, GuoP AGE, Boulianne M, Janardhana V, Bean AG, Hughes RJ (2011) The effects of lactoferrin on the intestinal environment of broiler chickens. Br Poult Sci 52:564\u2013572. https:\/\/doi.org\/10.1080\/00071668.2011.607429","journal-title":"Br Poult Sci"},{"key":"9964_CR45","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.2527\/jas.2006-754","volume":"85","author":"T Shan","year":"2007","unstructured":"Shan T, Wang Y, Wang Y, Liu J, Xu Z (2007) Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets. J Anim Sci 85:2140\u20132146. https:\/\/doi.org\/10.2527\/jas.2006-754","journal-title":"J Anim Sci"},{"key":"9964_CR46","doi-asserted-by":"publisher","first-page":"5361","DOI":"10.1039\/C9FO00676A","volume":"10","author":"P Hu","year":"2019","unstructured":"Hu P, Zhao F, Zhu W, Wang J (2019) Effects of early-life lactoferrin intervention on growth performance, small intestinal function and gut microbiota in suckling piglets. Food Funct 10:5361\u20135373. https:\/\/doi.org\/10.1039\/C9FO00676A","journal-title":"Food Funct"},{"key":"9964_CR47","unstructured":"Wajda S, Smiecinska K, Jankowski J, Matusevicius P, Buteikis G (2010) The efficacy of lactic acid bacteria Pediococcus acidilactici, lactose and formic acid as dietary supplements for turkeys.\u00a0Pol J Vet Sci\u00a013:45. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21077430"},{"key":"9964_CR48","doi-asserted-by":"publisher","first-page":"212","DOI":"10.4103\/ejh.ejh_30_18","volume":"43","author":"M El Barbary","year":"2018","unstructured":"El Barbary M, Shady NA, Shaaban HA, Shaaban MA, Ahmed OY (2018) Effect of enteral bovine lactoferrin on neonatal iron status. Egypt J Haematol 43:212. https:\/\/doi.org\/10.4103\/ejh.ejh_30_18","journal-title":"Egypt J Haematol"},{"key":"9964_CR49","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.3168\/jds.2016-11969","volume":"100","author":"G Habing","year":"2017","unstructured":"Habing G, Harris K, Schuenemann GM, Pi\u00f1eiro JM, Lakritz J, Clavijo XA (2017) Lactoferrin reduces mortality in preweaned calves with diarrhea. J Dairy Sci 100:3940\u20133948. https:\/\/doi.org\/10.3168\/jds.2016-11969","journal-title":"J Dairy Sci"},{"key":"9964_CR50","doi-asserted-by":"publisher","unstructured":"Joysowal M, Saikia BN, Dowarah R, Tamuly S, Kalita D, Choudhury KD (2018) Effect of probiotic Pediococcus acidilactici FT28 on growth performance, nutrient digestibility, health status, meat quality, and intestinal morphology in growing pigs.\u00a0Vet World\u00a011:1669. https:\/\/doi.org\/10.14202\/2Fvetworld.2018.1669-1676","DOI":"10.14202\/2Fvetworld.2018.1669-1676"},{"key":"9964_CR51","doi-asserted-by":"publisher","first-page":"6185","DOI":"10.1007\/s00253-020-10675-z","volume":"104","author":"P Hu","year":"2020","unstructured":"Hu P, Zhao F, WangJ ZhuW (2020) Early-life lactoferrin intervention modulates the colonic microbiota, colonic microbial metabolites and intestinal function in suckling piglets. Appl Microbiol Biotechnol 104:6185\u20136197. https:\/\/doi.org\/10.1007\/s00253-020-10675-z","journal-title":"Appl Microbiol Biotechnol"},{"key":"9964_CR52","doi-asserted-by":"publisher","unstructured":"Washington IM, Van Hoosier G (2012) Clinical biochemistry and hematology. In\u00a0The laboratory rabbit, guinea pig, hamster, and other rodents,\u00a0Academic Press, Pp. 57\u2013116. https:\/\/doi.org\/10.1016\/B978-0-12-380920-9.00003-1","DOI":"10.1016\/B978-0-12-380920-9.00003-1"},{"key":"9964_CR53","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1071\/AN12372","volume":"54","author":"X Dong","year":"2013","unstructured":"Dong X, Zhang N, Zhou M, Tu Y, Deng K, Diao Q (2013) Effects of dietary probiotics on growth performance, faecal microbiota and serum profiles in weaned piglets. Anim Prod Sci 54:616\u2013621. https:\/\/doi.org\/10.1071\/AN12372","journal-title":"Anim Prod Sci"},{"key":"9964_CR54","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1039\/D0FO01747G","volume":"12","author":"P Hu","year":"2021","unstructured":"Hu P, Zhao F, Wang J, Zhu W (2021) Metabolomic profiling reveals the effects of early-life lactoferrin intervention on protein synthesis, energy production and antioxidative capacity in the liver of suckling piglets. Food Funct 12:3405\u20133419. https:\/\/doi.org\/10.1039\/D0FO01747G","journal-title":"Food Funct"},{"key":"9964_CR55","unstructured":"Al-Zubaidi HJ, Falih IB (2018) Immunological and pathological effect of lactoferrin against murine leishmaniasis.\u00a0J Entomol Zool Stud\u00a06:1108\u20131111. https:\/\/www.entomoljournal.com\/archives\/2018\/vol6issue1\/PartP\/5-6-345-520.pdf"},{"key":"9964_CR56","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1093\/jn\/134.2.403","volume":"134","author":"RM Sfeir","year":"2004","unstructured":"Sfeir RM, Dubarry M, Boyaka PN, Rautureau M, Tome D (2004) The mode of oral bovine lactoferrin administration influences mucosal and systemic immune responses in mice. J Nutr 134:403\u2013409. https:\/\/doi.org\/10.1093\/jn\/134.2.403","journal-title":"J Nutr"},{"key":"9964_CR57","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/mi.2014.121","volume":"8","author":"YS Jang","year":"2015","unstructured":"Jang YS, Seo GY, Lee JM, Seo HY, Han HJ, Kim SJ, Jin BR, Kim HJ, Park SR, Rhee KJ, Kim WS, Kim PH (2015) Lactoferrin causes IgA and IgG2b isotype switching through betaglycan binding and activation of canonical TGF-\u03b2 signaling. Mucosal Immunol 8:906\u2013917. https:\/\/doi.org\/10.1038\/mi.2014.121","journal-title":"Mucosal Immunol"},{"key":"9964_CR58","doi-asserted-by":"publisher","unstructured":"Lee JM, Jang YS, Jin BR, Kim SJ, Kim HJ, Kwon BE, Ko HJ, Yoon SI, Lee GS, Kim WS, Seo GY, Kim PH, (2016) Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression. Cell Mol Immunol 13:862\u2013870. https:\/\/doi.org\/10.1038\/cmi.2015.73","DOI":"10.1038\/cmi.2015.73"},{"key":"9964_CR59","doi-asserted-by":"publisher","unstructured":"Yu LT, Ju CC, Ju J, Wu HL, Yen HT (2004) Effect of probiotics and selenium combination on the immune and blood cholesterol concentration of pigs. J Anim Feed Sci 13:625\u2013634. https:\/\/doi.org\/10.22358\/jafs\/67630\/2004","DOI":"10.22358\/jafs\/67630\/2004"},{"key":"9964_CR60","unstructured":"Karamese M, Aydin H, Sengul E, Gelen V, Sevim C, Ustek D, Karakus E (2016) The immunostimulatory effect of lactic acid bacteria in a rat model.\u00a0Iran J Immunol\u00a013:220\u2013228. http:\/\/iji.sums.ac.ir\/article_33410_0.html"},{"key":"9964_CR61","doi-asserted-by":"publisher","unstructured":"Aiyegoro O, Dlamini Z, Okoh A, Langa1 R (2017) Effects of probiotics on growth performance, blood parameters, and antibody stimulation in piglets.\u00a0S Afr J Anim Sci 47:766-775. http:\/\/dx.doi.org\/https:\/\/doi.org\/10.4314\/sajas.v47i6.4","DOI":"10.4314\/sajas.v47i6.4"},{"key":"9964_CR62","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.imlet.2009.11.005","volume":"128","author":"AA Resendiz-Albor","year":"2010","unstructured":"Resendiz-Albor AA, Reina-Garfias H, Rojas-Hernandez S, Jarillo-Luna A, Rivera-Aguilar V, Miliar-Garcia A, Campos-Rodriguez R (2010) Regionalization of pIgR expression in the mucosa of mouse small intestine. Immunol Lett 128:59\u201367. https:\/\/doi.org\/10.1016\/j.imlet.2009.11.005","journal-title":"Immunol Lett"},{"key":"9964_CR63","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.anifeedsci.2014.12.005","volume":"201","author":"IA Naqid","year":"2015","unstructured":"Naqid IA, Owen JP, Maddison BC, Gardner DS, Foster N, Tch\u00f3rzewska MA, La Ragione RM, Gough KC (2015) Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella typhimurium infection in pigs. Anim Feed Sci Technol 201:57\u201365. https:\/\/doi.org\/10.1016\/j.anifeedsci.2014.12.005","journal-title":"Anim Feed Sci Technol"},{"key":"9964_CR64","doi-asserted-by":"publisher","unstructured":"Kim SH, Jeung W, Choi ID, Jeong JW, Lee DE, Huh CS,\u00a0Kim GB, Hong SS, Shim JJ, Lee, Sim SH, JL, Ahn YT (2016) Lactic acid bacteria improve Peyer's patch cell-mediated immunoglobulin A and tight-junction expression in a destructed gut microbial environment.\u00a0J Microbiol Biotechnol\u00a026:1035\u20131045.https:\/\/doi.org\/10.4014\/jmb.1512.12002","DOI":"10.4014\/jmb.1512.12002"},{"key":"9964_CR65","doi-asserted-by":"publisher","unstructured":"Liu H, Wang S, Zhang D, Wang J, Zhang W, Wang Y, Ji H (2020) Effects of dietary supplementation with Pediococcus acidilactici ZPA017 on reproductive performance, fecal microbial flora and serum indices in sows during late gestation and lactation.\u00a0Asian-Australas J Anim Sci\u00a033:120. https:\/\/doi.org\/10.5713\/2Fajas.18.0764","DOI":"10.5713\/2Fajas.18.0764"},{"key":"9964_CR66","doi-asserted-by":"publisher","unstructured":"Vadopalas L, Ruzauskas M, Lele V, Starkute V, Zavistanaviciute P, Zokaityte E, Bartkevics V, Pugajeva I, Reinolds I, Badaras S, Klupsaite D, Bartkiene E (2020) Combination of antimicrobial starters for feed fermentation: influence on piglet feces microbiota and health and growth performance, including mycotoxin biotransformation in vivo. Front Vet Sci\u00a07:528990. https:\/\/doi.org\/10.3389\/2Ffvets.2020.528990","DOI":"10.3389\/2Ffvets.2020.528990"},{"key":"9964_CR67","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3923\/javaa.2010.604.609","volume":"9","author":"MY Al-Saiady","year":"2010","unstructured":"Al-Saiady MY (2010) Effect of probiotic bacteria on immunoglobulin G concentration and other blood components of newborn calves. J Anim Vet Adv 9:604\u2013609. https:\/\/doi.org\/10.3923\/javaa.2010.604.609","journal-title":"J Anim Vet Adv"},{"key":"9964_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.animal.2020.100124","volume":"15","author":"A Karamzadeh-Dehaghani","year":"2021","unstructured":"Karamzadeh-Dehaghani A, Towhidi A, Zhandi M, Mojgani N, Fouladi-Nashta A (2021) Combined effect of probiotics and specific immunoglobulin Y directed against Escherichia coli on growth performance, diarrhea incidence, and immune system in calves. Animal 15:100124. https:\/\/doi.org\/10.1016\/j.animal.2020.100124","journal-title":"Animal"},{"key":"9964_CR69","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.3389\/fimmu.2018.01407","volume":"9","author":"E Troncone","year":"2018","unstructured":"Troncone E, Marafini I, Stolfi C, Monteleone G (2018) Transforming growth factor-\u03b21\/Smad7 in intestinal immunity, inflammation, and cancer. Front Immunol 9:1407. https:\/\/doi.org\/10.3389\/fimmu.2018.01407","journal-title":"Front Immunol"},{"key":"9964_CR70","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1053\/j.gastro.2021.04.064","volume":"161","author":"NR Gough","year":"2021","unstructured":"Gough NR, Xiang X, Mishra L (2021) TGF-\u03b2 signaling in liver, pancreas, and gastrointestinal diseases and cancer. Gastroenterol 161:434-452.e15. https:\/\/doi.org\/10.1053\/j.gastro.2021.04.064","journal-title":"Gastroenterol"},{"key":"9964_CR71","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1093\/intimm\/dxp084","volume":"21","author":"SA Hwang","year":"2009","unstructured":"Hwang SA, Actor JK (2009) Lactoferrin modulation of BCG-infected dendritic cell functions. Int Immunol 21:1185\u20131197. https:\/\/doi.org\/10.1093\/intimm\/dxp084","journal-title":"Int Immunol"},{"key":"9964_CR72","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1139\/bcb-2020-0182","volume":"99","author":"B L\u00f6nnerdal","year":"2021","unstructured":"L\u00f6nnerdal B, Du X, Jiang R (2021) Biological activities of commercial bovine lactoferrin sources. Biochem Cell Biol 99:35\u201346. https:\/\/doi.org\/10.1139\/bcb-2020-0182","journal-title":"Biochem Cell Biol"},{"key":"9964_CR73","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1074\/jbc.m303654200","volume":"279","author":"G Monteleone","year":"2004","unstructured":"Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Del Vecchio BG, Tersigni R, Alessandroni L, Mann D, Pallone F, MacDonald TT (2004) A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. J Biol Chem 279:3925\u20133932. https:\/\/doi.org\/10.1074\/jbc.m303654200","journal-title":"J Biol Chem"},{"key":"9964_CR74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105370","volume":"9","author":"F Sakai","year":"2014","unstructured":"Sakai F, Hosoya T, Ono-Ohmachi A, Ukibe K, Ogawa A, Moriya T, Kadooka Y, Shiozaki T, Nakagawa H, Nakayama Y, Miyazaki T (2014) Lactobacillus gasseri SBT2055 induces TGF-\u03b2 expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine. PLoS ONE 9:e105370. https:\/\/doi.org\/10.1371\/journal.pone.0105370","journal-title":"PLoS ONE"},{"key":"9964_CR75","doi-asserted-by":"publisher","unstructured":"Huang IF, Lin IC, Liu PF, Cheng MF, Liu YC, Hsieh YD, Chen JJ, Chen CL, Chang HW, Shu CW (2015) Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-\u03b2 signaling. BMC Microbiol 15:203. https:\/\/doi.org\/10.1186\/2Fs12866-015-0546-x","DOI":"10.1186\/2Fs12866-015-0546-x"},{"key":"9964_CR76","doi-asserted-by":"publisher","unstructured":"Barigela A, Bhukya B (2021) Probiotic Pediococcus acidilactici strain from tomato pickle displays anti-cancer activity and alleviates gut inflammation in-vitro.\u00a03Biotech\u00a011:1\u201311. https:\/\/doi.org\/10.1007\/s13205-020-02570-1","DOI":"10.1007\/s13205-020-02570-1"},{"key":"9964_CR77","doi-asserted-by":"publisher","unstructured":"Foye OT, Huang IF, Chiou CC, Walker WA, Shi HN (2012) Early administration of probiotic Lactobacillus acidophilus and\/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling. FEMS Immunol Med Microbiol 65(3):467\u201380. https:\/\/doi.org\/10.1111\/2Fj.1574-695X.2012.00978.x","DOI":"10.1111\/2Fj.1574-695X.2012.00978.x"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-022-09964-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-022-09964-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-022-09964-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T09:34:52Z","timestamp":1673602492000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-022-09964-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["9964"],"URL":"https:\/\/doi.org\/10.1007\/s12602-022-09964-y","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"assertion":[{"value":"9 June 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. All procedures used during the research were approved by the Institute Animal Ethics Committee, and the research protocol was approved by the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Fisheries, Animal Husbandry and Dairying, Government of India (approval number V-11\u201311 (13)\/19\/2021-CPCSEA-DADF).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}