{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:37:33Z","timestamp":1788518253896,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"crossref","award":["DMR-106-176"],"award-info":[{"award-number":["DMR-106-176"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"crossref","award":["CMU107-ASIA-07"],"award-info":[{"award-number":["CMU107-ASIA-07"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100022298","name":"Hualien Tzu Chi Hospital","doi-asserted-by":"crossref","award":["IMAR-110-01-13"],"award-info":[{"award-number":["IMAR-110-01-13"]}],"id":[{"id":"10.13039\/501100022298","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s12602-022-09982-w","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T06:04:44Z","timestamp":1661925884000},"page":"1287-1297","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats"],"prefix":"10.1007","volume":"15","author":[{"given":"Jing-Ying","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce Chi-Kang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chuan","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yi","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Shao-Tsu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Jung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-0411","authenticated-orcid":false,"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"issue":"2","key":"9982_CR1","first-page":"V","volume":"1","author":"SA Tabish","year":"2007","unstructured":"Tabish SA (2007) Is diabetes becoming the biggest epidemic of the twenty-first century? Int J Health Sci (Qassim). 1(2):V\u2013VIII","journal-title":"Int J Health Sci (Qassim)."},{"key":"9982_CR2","doi-asserted-by":"publisher","DOI":"10.1051\/bmdcn\/2018080424","author":"FS Shad","year":"2018","unstructured":"Shad FS, Haghighi MJ (2018) Study of the effect of the essential oil (extract) of rhubarb stem (shoot) on glycosylated hemoglobin and fasting blood glucose levels in patients with type II diabetes. Biomedicine (Taipei). https:\/\/doi.org\/10.1051\/bmdcn\/2018080424","journal-title":"Biomedicine (Taipei)"},{"issue":"1","key":"9982_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1900\/RDS.2009.6.37","volume":"6","author":"AA Sima","year":"2009","unstructured":"Sima AA, Zhang W, Kreipke CW, Rafols JA, Hoffman WH (2009) Inflammation in diabetic encephalopathy is prevented by C-peptide. Rev Diabet Stud 6(1):37. https:\/\/doi.org\/10.1900\/RDS.2009.6.37","journal-title":"Rev Diabet Stud"},{"issue":"1","key":"9982_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41231-019-0043-6","volume":"4","author":"AK Thakur","year":"2019","unstructured":"Thakur AK, Tyagi S, Shekhar N (2019) Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugs. Transl Med Commun 4(1):1\u201313. https:\/\/doi.org\/10.1186\/s41231-019-0043-6","journal-title":"Transl Med Commun"},{"issue":"2","key":"9982_CR5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0006-8993(02)02887-1","volume":"946","author":"ZG Li","year":"2002","unstructured":"Li ZG, Zhang W, Grunberger G, Sima AA (2002) Hippocampal neuronal apoptosis in type 1 diabetes. Brain Res 946(2):221\u2013231. https:\/\/doi.org\/10.1016\/S0006-8993(02)02887-1","journal-title":"Brain Res"},{"issue":"2","key":"9982_CR6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.nbd.2006.03.015","volume":"23","author":"C Toth","year":"2006","unstructured":"Toth C, Schmidt AM, Tuor UI, Francis G, Foniok T, Brussee V, Kaur J, Yan SF, Martinez JA, Barber PA, Buchan A, Zochodne DW (2006) Diabetes, leukoencephalopathy and rage. Neurobiol Dis 23(2):445\u2013461. https:\/\/doi.org\/10.1016\/j.nbd.2006.03.015","journal-title":"Neurobiol Dis"},{"issue":"3","key":"9982_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1900\/RDS.2009.6.211","volume":"6","author":"AA Sima","year":"2009","unstructured":"Sima AA, Zhang W, Muzik O, Kreipke CW, Rafols JA, Hoffman WH (2009) Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-peptide. Rev Diabet Stud 6(3):211\u2013222. https:\/\/doi.org\/10.1900\/RDS.2009.6.211","journal-title":"Rev Diabet Stud"},{"issue":"12","key":"9982_CR8","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1590\/S0100-879X2008001200001","volume":"41","author":"CD Munhoz","year":"2008","unstructured":"Munhoz CD, Garcia-Bueno B, Madrigal JL, Lepsch LB, Scavone C, Leza JC (2008) Stress-induced neuroinflammation: mechanisms and new pharmacological targets. Braz J Med Biol Res 41(12):1037\u20131046. https:\/\/doi.org\/10.1590\/S0100-879X2008001200001","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"9982_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.2174\/156720506778249461","volume":"3","author":"C Culmsee","year":"2006","unstructured":"Culmsee C, Landshamer S (2006) Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders. Curr Alzheimer Res 3(4):269\u2013283. https:\/\/doi.org\/10.2174\/156720506778249461","journal-title":"Curr Alzheimer Res"},{"key":"9982_CR10","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.jff.2013.11.020","volume":"6","author":"CY Huang","year":"2014","unstructured":"Huang CY, Kuo WW, Wang HF, Lin CJ, Lin YM, Chen JL, Kuo CH, Chen PK, Lin JY (2014) GABA tea ameliorates cerebral cortex apoptosis and autophagy in streptozotocin-induced rats. J Funct Foods 6:534\u2013544. https:\/\/doi.org\/10.1016\/j.jff.2013.11.020","journal-title":"J Funct Foods"},{"issue":"7530","key":"9982_CR11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/nature13788","volume":"516","author":"JR Lukens","year":"2014","unstructured":"Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Vande Walle L, Lamkanfi M, Kanneganti TD (2014) Dietary modulation of the microbiome affects autoinflammatory disease. Nature 516(7530):246\u2013249. https:\/\/doi.org\/10.1038\/nature13788","journal-title":"Nature"},{"issue":"1","key":"9982_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0928-0987(01)00209-3","volume":"15","author":"IP Kaur","year":"2002","unstructured":"Kaur IP, Chopra K, Saini A (2002) Probiotics: potential pharmaceutical applications. Eur J Pharm Sci 15(1):1\u20139. https:\/\/doi.org\/10.1016\/S0928-0987(01)00209-3","journal-title":"Eur J Pharm Sci"},{"issue":"2S Suppl","key":"9982_CR13","doi-asserted-by":"publisher","first-page":"410S","DOI":"10.1093\/jn\/130.2.410S","volume":"130","author":"LJ Brady","year":"2000","unstructured":"Brady LJ, Gallaher DD, Busta FF (2000) The role of probiotic cultures in the prevention of colon cancer. J Nutr 130(2S Suppl):410S-414S. https:\/\/doi.org\/10.1093\/jn\/130.2.410S","journal-title":"J Nutr"},{"issue":"6","key":"9982_CR14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2323\/jgam.56.481","volume":"56","author":"TW Liang","year":"2010","unstructured":"Liang TW, Wu YY, Huang TY, Wang CY, Yen YH, Liu CP, Chen YC, Wang SL (2010) Conversion of squid pen by a novel strain Lactobacillus paracasei subsp. paracasei TKU010, and its application in antimicrobial and antioxidants activity. J Gen Appl Microbiol 56(6):481\u2013489. https:\/\/doi.org\/10.2323\/jgam.56.481","journal-title":"J Gen Appl Microbiol"},{"issue":"6","key":"9982_CR15","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jbiosc.2010.07.006","volume":"110","author":"YC Lu","year":"2010","unstructured":"Lu YC, Yin LT, Chang WT, Huang JS (2010) Effect of Lactobacillus reuteri GMNL-263 treatment on renal fibrosis in diabetic rats. J Biosci Bioeng 110(6):709\u2013715. https:\/\/doi.org\/10.1016\/j.jbiosc.2010.07.006","journal-title":"J Biosci Bioeng"},{"issue":"4","key":"9982_CR16","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1007\/s12602-021-09745-z","volume":"13","author":"KP Koay","year":"2021","unstructured":"Koay KP, Tsai BCK, Kuo CH, Kuo WW, Luk HN, Day CH, Chen RJ, Chen MYC, Padma VV, Huang CY (2021) Hyperglycemia-induced cardiac damage is alleviated by heat-inactivated lactobacillus reuteri GMNL-263 via activation of the IGF1R survival pathway. Probiotics Antimicrob Proteins 13(4):1044\u20131053. https:\/\/doi.org\/10.1007\/s12602-021-09745-z","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"6","key":"9982_CR17","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1007\/s00394-020-02474-z","volume":"60","author":"CJ Chiang","year":"2021","unstructured":"Chiang CJ, Tsai BCK, Lu TL, Chao YP, Day CH, Ho TJ, Wang PN, Lin SC, Padma VV, Kuo WW (2021) Diabetes-induced cardiomyopathy is ameliorated by heat-killed Lactobacillus reuteri GMNL-263 in diabetic rats via the repression of the Toll-like receptor 4 pathway. Eur J Nutr 60(6):3211\u20133223. https:\/\/doi.org\/10.1007\/s00394-020-02474-z","journal-title":"Eur J Nutr"},{"issue":"3","key":"9982_CR18","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10123-018-00051-3","volume":"22","author":"G Mohammadi","year":"2019","unstructured":"Mohammadi G, Dargahi L, Naserpour T, Mirzanejad Y, Alizadeh SA, Peymani A, Nassiri-Asl M (2019) Probiotic mixture of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 attenuates hippocampal apoptosis induced by lipopolysaccharide in rats. Int Microbiol 22(3):317\u2013323. https:\/\/doi.org\/10.1007\/s10123-018-00051-3","journal-title":"Int Microbiol"},{"issue":"38","key":"9982_CR19","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","volume":"108","author":"JA Bravo","year":"2011","unstructured":"Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A 108(38):16050\u201316055. https:\/\/doi.org\/10.1073\/pnas.1102999108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"9982_CR20","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1073\/pnas.1102999108","volume":"139","author":"P Bercik","year":"2010","unstructured":"Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang X, Malinowski P, Jackson W, Blennerhassett P, Neufeld KA, Lu J, Khan WI, Corthesy-Theulaz I, Cherbut C, Bergonzelli GE, Collins SM (2010) Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology 139(6):2102-2112.e1. https:\/\/doi.org\/10.1073\/pnas.1102999108","journal-title":"Gastroenterology"},{"key":"9982_CR21","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuroscience.2013.02.055","volume":"240","author":"S Davari","year":"2013","unstructured":"Davari S, Talaei SA, Alaei H, Salami M (2013) Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome-gut-brain axis. Neuroscience 240:287\u2013296. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.02.055","journal-title":"Neuroscience"},{"issue":"5","key":"9982_CR22","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1017\/S0007114515002469","volume":"114","author":"WJ Ting","year":"2015","unstructured":"Ting WJ, Kuo WW, Kuo CH, Yeh YL, Shen CY, Chen YH, Ho TJ, Viswanadha VP, Chen YH, Huang CY (2015) Supplementary heat-killed Lactobacillus reuteri GMNL-263 ameliorates hyperlipidaemic and cardiac apoptosis in high-fat diet-fed hamsters to maintain cardiovascular function. Br J Nutr 114(5):706\u2013712. https:\/\/doi.org\/10.1017\/S0007114515002469","journal-title":"Br J Nutr"},{"key":"9982_CR23","volume-title":"Guide for the care and use of laboratory animals","author":"U Albus","year":"2012","unstructured":"Albus U (2012) Guide for the care and use of laboratory animals, 8th edn. London, England, SAGE Publications Sage UK","edition":"8"},{"issue":"2","key":"9982_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7603\/s40681-014-0012-3","volume":"4","author":"WC Chiu","year":"2014","unstructured":"Chiu WC, Yang HH, Chiang SC, Chou YX, Yang HT (2014) Auricularia polytricha aqueous extract supplementation decreases hepatic lipid accumulation and improves antioxidative status in animal model of nonalcoholic fatty liver. Biomedicine (Taipei) 4(2):1\u201310. https:\/\/doi.org\/10.7603\/s40681-014-0012-3","journal-title":"Biomedicine (Taipei)"},{"issue":"1","key":"9982_CR25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12602-020-09668-1","volume":"13","author":"YL Yeh","year":"2021","unstructured":"Yeh YL, Lu MC, Tsai BCK, Tzang BS, Cheng SM, Zhang X, Yang LY, Mahalakshmi B, Kuo WW, Xiang P, Huang CY (2021) Heat-killed Lactobacillus reuteri GMNL-263 inhibits systemic lupus erythematosus\u2013induced cardiomyopathy in NZB\/W F1 mice. Probiotics Antimicro Prot 13(1):51\u201359. https:\/\/doi.org\/10.1007\/s12602-020-09668-1","journal-title":"Probiotics Antimicro Prot"},{"key":"9982_CR26","doi-asserted-by":"publisher","unstructured":"Achudhan D, Chang SL-Y, Liu S-C, Lin Y-Y, Huang W-C, Wu Y-C, Huang C-C, Tsai C-H, Ko C-Y, Kuo Y-H (2022) Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res 66. https:\/\/doi.org\/10.29219\/fnr.v66.8645","DOI":"10.29219\/fnr.v66.8645"},{"issue":"1","key":"9982_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12986-020-0432-x","volume":"17","author":"S-P Liu","year":"2020","unstructured":"Liu S-P, Shibu MA, Tsai F-J, Hsu Y-M, Tsai C-H, Chung J-G, Yang J-S, Tang C-H, Wang S, Li Q, Huang C-Y (2020) Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1\u03b1 induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis. Nutr Metab (Lond) 17(1):1\u20139. https:\/\/doi.org\/10.1186\/s12986-020-0432-x","journal-title":"Nutr Metab (Lond)"},{"issue":"8","key":"9982_CR28","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1002\/tox.23153","volume":"36","author":"WY Lin","year":"2021","unstructured":"Lin WY, Tsai BCK, Day CH, Chiu PL, Chen RJ, Chen MYC, Padma VV, Luk HN, Lee HC, Huang CY (2021) Arecoline induces heart injure via Fas\/Fas ligand apoptotic pathway in heart of Sprague-Dawley rat. Environ Toxicol 36(8):1567\u20131575. https:\/\/doi.org\/10.1002\/tox.23153","journal-title":"Environ Toxicol"},{"issue":"6","key":"9982_CR29","doi-asserted-by":"publisher","first-page":"e13666","DOI":"10.1111\/jfbc.13666","volume":"45","author":"WS Chang","year":"2021","unstructured":"Chang WS, Tsai CW, Yang JS, Hsu YM, Shih LC, Chiu HY, Bau DT, Tsai FJ (2021) Resveratrol inhibited the metastatic behaviors of cisplatin-resistant human oral cancer cells via phosphorylation of ERK\/p-38 and suppression of MMP-2\/9. J Food Biochem 45(6):e13666. https:\/\/doi.org\/10.1111\/jfbc.13666","journal-title":"J Food Biochem"},{"key":"9982_CR30","doi-asserted-by":"publisher","first-page":"109810","DOI":"10.1016\/j.cbi.2022.109810","volume":"354","author":"TJ Ho","year":"2022","unstructured":"Ho TJ, Tsai BC, Kuo CH, Luk HN, Day CH, Hsieh DJ, Chen RJ, Kuo WW, Kumar VB, Yao CH, Huang CY (2022) Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague-Dawley rats. Chem Biol Interact 354:109810. https:\/\/doi.org\/10.1016\/j.cbi.2022.109810","journal-title":"Chem Biol Interact"},{"issue":"4","key":"9982_CR31","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1017\/S0007114513002791","volume":"111","author":"CH Lin","year":"2014","unstructured":"Lin CH, Lin CC, Shibu MA, Liu CS, Kuo CH, Tsai FJ, Tsai CH, Hsieh CH, Chen YH, Huang CY (2014) Oral Lactobacillus reuteri GMN-32 treatment reduces blood glucose concentrations and promotes cardiac function in rats with streptozotocin-induced diabetes mellitus. Br J Nutr 111(4):598\u2013605. https:\/\/doi.org\/10.1017\/S0007114513002791","journal-title":"Br J Nutr"},{"issue":"3","key":"9982_CR32","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1017\/S0007114513002791","volume":"57","author":"J Luo","year":"2014","unstructured":"Luo J, Wang T, Liang S, Hu X, Li W, Jin F (2014) Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat. Sci China Life Sci 57(3):327\u2013335. https:\/\/doi.org\/10.1017\/S0007114513002791","journal-title":"Sci China Life Sci"},{"issue":"11","key":"9982_CR33","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.3390\/nu9111247","volume":"9","author":"T Cerd\u00f3","year":"2017","unstructured":"Cerd\u00f3 T, Ru\u00edz A, Su\u00e1rez A, Campoy C (2017) Probiotic, prebiotic, and brain development. Nutrients 9(11):1247. https:\/\/doi.org\/10.3390\/nu9111247","journal-title":"Nutrients"},{"issue":"1","key":"9982_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-7075-10-35","volume":"10","author":"FC Hsieh","year":"2013","unstructured":"Hsieh FC, Lee CL, Chai CY, Chen WT, Lu YC, Wu CS (2013) Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats. Nutr Metab (Lond) 10(1):1\u201314. https:\/\/doi.org\/10.1186\/1743-7075-10-35","journal-title":"Nutr Metab (Lond)"},{"key":"9982_CR35","doi-asserted-by":"publisher","first-page":"626019","DOI":"10.1155\/2015\/626019","volume":"2015","author":"D Zhang","year":"2015","unstructured":"Zhang D, Jiang S, Meng H (2015) Role of the insulin-like growth factor type 1 receptor in the pathogenesis of diabetic encephalopathy. Int J Endocrinol 2015:626019. https:\/\/doi.org\/10.1155\/2015\/626019","journal-title":"Int J Endocrinol"},{"issue":"1\u20132","key":"9982_CR36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.brainres.2004.02.042","volume":"1009","author":"VC Russo","year":"2004","unstructured":"Russo VC, Kobayashi K, Najdovska S, Baker NL, Werther GA (2004) Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: a role for the insulin-like growth factor system. Brain Res 1009(1\u20132):40\u201353. https:\/\/doi.org\/10.1016\/j.brainres.2004.02.042","journal-title":"Brain Res"},{"key":"9982_CR37","doi-asserted-by":"publisher","unstructured":"Genis L, D\u00e1vila D, Fernandez S, Pozo-Rodrig\u00e1lvarez A, Mart\u00ednez-Murillo R, Torres-Aleman I (2014) Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury. F1000Research 3:28. https:\/\/doi.org\/10.12688\/f1000research.3-28.v2","DOI":"10.12688\/f1000research.3-28.v2"},{"key":"9982_CR38","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3389\/fncel.2019.00298","volume":"13","author":"W Chen","year":"2019","unstructured":"Chen W, He B, Tong W, Zeng J, Zheng P (2019) Astrocytic insulin-like growth factor-1 protects neurons against excitotoxicity. Front Cell Neurosci 13:298. https:\/\/doi.org\/10.3389\/fncel.2019.00298","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"9982_CR39","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.neulet.2012.10.045","volume":"531","author":"I Aksu","year":"2012","unstructured":"Aksu I, Ates M, Baykara B, Kiray M, Sisman AR, Buyuk E, Baykara B, Cetinkaya C, Gumus H, Uysal N (2012) Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes. Neurosci Lett 531(2):176\u2013181. https:\/\/doi.org\/10.1016\/j.neulet.2012.10.045","journal-title":"Neurosci Lett"},{"key":"9982_CR40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jare.2020.06.015","volume":"28","author":"S Lay","year":"2021","unstructured":"Lay S, Kuo WW, Shibu MA, Ho TJ, Cheng SM, Day CH, Ban B, Wang S, Li Q, Huang CY (2021) Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis. J Adv Res 28:35\u201341. https:\/\/doi.org\/10.1016\/j.jare.2020.06.015","journal-title":"J Adv Res"},{"issue":"5","key":"9982_CR41","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s10522-021-09929-8","volume":"22","author":"JY Lin","year":"2021","unstructured":"Lin JY, Ho TJ, Tsai BCK, Chiang CY, Kao HC, Kuo WW, Chen RJ, Viswanadha VP, Huang CW, Huang CY (2021) Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex. Biogerontology 22(5):495\u2013506. https:\/\/doi.org\/10.1007\/s10522-021-09929-8","journal-title":"Biogerontology"},{"key":"9982_CR42","doi-asserted-by":"publisher","first-page":"108862","DOI":"10.1016\/j.foodres.2019.108862","volume":"129","author":"BCK Tsai","year":"2020","unstructured":"Tsai BCK, Hsieh DJY, Lin WT, Tamilselvi S, Day CH, Ho TJ, Chang RL, Viswanadha VP, Kuo CH, Huang CY (2020) Functional potato bioactive peptide intensifies Nrf2-dependent antioxidant defense against renal damage in hypertensive rats. Food Res Int 129:108862. https:\/\/doi.org\/10.1016\/j.foodres.2019.108862","journal-title":"Food Res Int"},{"issue":"15","key":"9982_CR43","doi-asserted-by":"publisher","first-page":"8142","DOI":"10.3390\/ijms22158142","volume":"22","author":"L Szablewski","year":"2021","unstructured":"Szablewski L (2021) Brain glucose transporters: role in pathogenesis and potential targets for the treatment of Alzheimer\u2019s disease. Int J Mol Sci 22(15):8142. https:\/\/doi.org\/10.3390\/ijms22158142","journal-title":"Int J Mol Sci"},{"issue":"10","key":"9982_CR44","doi-asserted-by":"publisher","first-page":"12629","DOI":"10.3390\/ijms131012629","volume":"13","author":"K Shah","year":"2012","unstructured":"Shah K, Desilva S, Abbruscato T (2012) The role of glucose transporters in brain disease: diabetes and Alzheimer\u2019s disease. Int J Mol Sci 13(10):12629\u201312655. https:\/\/doi.org\/10.3390\/ijms131012629","journal-title":"Int J Mol Sci"},{"issue":"10","key":"9982_CR45","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.2337\/dc10-0770","volume":"33","author":"S Teppala","year":"2010","unstructured":"Teppala S, Shankar A (2010) Association between serum IGF-1 and diabetes among U.S. adults. Diabetes Care 33(10):2257\u20132259. https:\/\/doi.org\/10.2337\/dc10-0770","journal-title":"Diabetes Care"},{"key":"9982_CR46","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.brainres.2011.10.046","volume":"1430","author":"J Yu","year":"2012","unstructured":"Yu J, Li J, Zhang S, Xu X, Zheng M, Jiang G, Li F (2012) IGF-1 induces hypoxia-inducible factor 1\u03b1-mediated GLUT3 expression through PI3K\/Akt\/mTOR dependent pathways in PC12 cells. Brain Res 1430:18\u201324. https:\/\/doi.org\/10.1016\/j.brainres.2011.10.046","journal-title":"Brain Res"},{"issue":"3","key":"9982_CR47","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1161\/01.ATV.0000105902.89459.09","volume":"24","author":"P Delafontaine","year":"2004","unstructured":"Delafontaine P, Song YH, Li Y (2004) Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 24(3):435\u2013444. https:\/\/doi.org\/10.1161\/01.ATV.0000105902.89459.09","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9982_CR48","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.molmet.2018.11.008","volume":"20","author":"MR Aghanoori","year":"2019","unstructured":"Aghanoori MR, Smith DR, Shariati-Ievari S, Ajisebutu A, Nguyen A, Desmond F, Jesus CH, Zhou X, Calcutt NA, Aliani M (2019) Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes. Mol Metab 20:149\u2013165. https:\/\/doi.org\/10.1016\/j.molmet.2018.11.008","journal-title":"Mol Metab"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-022-09982-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-022-09982-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-022-09982-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:08:22Z","timestamp":1694160502000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-022-09982-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["9982"],"URL":"https:\/\/doi.org\/10.1007\/s12602-022-09982-w","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"17 August 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols were approved by the Institutional Animal Care and Use Committee of China Medical University, Taichung, Taiwan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors agree the publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}