{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:45:36Z","timestamp":1788403536920,"version":"build-2803163510"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.506517\/2020-00"],"award-info":[{"award-number":["88887.506517\/2020-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.506517\/2020-00"],"award-info":[{"award-number":["88887.506517\/2020-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.506517\/2020-00"],"award-info":[{"award-number":["88887.506517\/2020-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s12602-022-09998-2","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T08:02:38Z","timestamp":1667894558000},"page":"1513-1528","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lactobacillus rhamnosus Restores Antiviral Signaling and Attenuates Cytokines Secretion from Human Bronchial Epithelial Cells Exposed to Cigarette Smoke and Infected with SARS-CoV-2"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-3904","authenticated-orcid":false,"given":"Fabiana","family":"Ol\u00edmpio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-3756","authenticated-orcid":false,"given":"Robert","family":"Andreata-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-056X","authenticated-orcid":false,"given":"Paloma Cristina","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-773X","authenticated-orcid":false,"given":"Wellington","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-2850","authenticated-orcid":false,"given":"Carlos","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-541X","authenticated-orcid":false,"given":"Flavio","family":"Aimbire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"9998_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ccm.2013.09.011","volume":"35","author":"S Salvi","year":"2014","unstructured":"Salvi S (2014) Tobacco smoking and environmental risk factors for chronic obstructive pulmonary disease. Clin Chest Med 35:17\u201327. https:\/\/doi.org\/10.1016\/j.ccm.2013.09.011","journal-title":"Clin Chest Med"},{"issue":"2","key":"9998_CR2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/imm.12077","volume":"139","author":"E Pace","year":"2013","unstructured":"Pace E, Ferraro M, Di Vincenzo S et al (2013) Cigarette smoke increases BLT2 receptor functions in bronchial epithelial cells: in vitro and ex vivo evidence. Immunology 139(2):245\u2013255. https:\/\/doi.org\/10.1111\/imm.12077","journal-title":"Immunology"},{"key":"9998_CR3","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.2147\/COPD.S176122","volume":"13","author":"Y Wang","year":"2014","unstructured":"Wang Y, Xu J, Meng Y et al (2014) Role of inflammatory cells in airway remodeling in COPD. Int J Chron Obstruct Dis 13:3341\u20133348. https:\/\/doi.org\/10.2147\/COPD.S176122","journal-title":"Int J Chron Obstruct Dis"},{"issue":"2","key":"9998_CR4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/1945892420946968","volume":"35","author":"S Kwak","year":"2020","unstructured":"Kwak S, Choi YS, Na HG et al (2020) Glyoxal and methylglyoxal as e-cigarette vapor ingredients-induced pro-inflammatory cytokine and mucins expression in human nasal epithelial cells. Am J Rhinol Allergy 35(2):213\u2013220. https:\/\/doi.org\/10.1177\/1945892420946968","journal-title":"Am J Rhinol Allergy"},{"issue":"10 Suppl","key":"9998_CR5","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1097\/INF.0b013e3181684d67","volume":"27","author":"MB Sikkel","year":"2008","unstructured":"Sikkel MB, Quint JK, Mallia P et al (2008) Respiratory syncytial virus persistence in chronic obstructive pulmonary disease. Pediatr Infect Dis J 27(10 Suppl):S63-70. https:\/\/doi.org\/10.1097\/INF.0b013e3181684d67","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"9998_CR6","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.rmed.2005.06.001","volume":"100","author":"TE McManus","year":"2006","unstructured":"McManus TE, Coyle PV, Kidney JC (2006) Childhood respiratory infections and hospital admissions for COPD. Respir Med 100(3):512\u2013518. https:\/\/doi.org\/10.1016\/j.rmed.2005.06.001. Epub 2005 Jul 25","journal-title":"Respir Med"},{"key":"9998_CR7","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.3389\/fimmu.2019.02765","volume":"10","author":"M Menzel","year":"2019","unstructured":"Menzel M, Ramu S, Calv\u00e9n J et al (2019) Oxidative stress attenuates TLR3 responsiveness and impairs anti-viral mechanisms in bronchial epithelial cells from COPD and asthma patients. Front Immunol 10:2765. https:\/\/doi.org\/10.3389\/fimmu.2019.02765","journal-title":"Front Immunol"},{"issue":"11","key":"9998_CR8","doi-asserted-by":"publisher","first-page":"L848","DOI":"10.1152\/ajplung.00158.2014","volume":"307","author":"W Wu","year":"2014","unstructured":"Wu W, Zhang W, More S et al (2014) Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models. Am J Physiol Lung Cell Mol Physiol 307(11):L848\u2013L858. https:\/\/doi.org\/10.1152\/ajplung.00158.2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"9998_CR9","doi-asserted-by":"publisher","first-page":"e0217803","DOI":"10.1371\/journal.pone.0217803","volume":"14","author":"J Garc\u00eda-Valero","year":"2019","unstructured":"Garc\u00eda-Valero J, Olloquequi J, Montes JF et al (2019) Deficient pulmonary IFN-\u03b2 expression in COPD patients. PLoS ONE 14(6):e0217803. https:\/\/doi.org\/10.1371\/journal.pone.0217803","journal-title":"PLoS ONE"},{"issue":"1","key":"9998_CR10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1465-9921-11-64","volume":"11","author":"MA Modestou","year":"2010","unstructured":"Modestou MA, Manzel LJ, El-Mahdy S et al (2010) Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke. Respir Res 11(1):64. https:\/\/doi.org\/10.1186\/1465-9921-11-64","journal-title":"Respir Res"},{"issue":"3","key":"9998_CR11","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.intimp.2012.04.007","volume":"13","author":"I Mahmutovic-Persson","year":"2012","unstructured":"Mahmutovic-Persson I, Johansson M, Brandelius A et al (2012) Capacity of capsazepinoids to relax human small airways and inhibit TLR3-induced TSLP and IFN\u03b2 production in diseased bronchial epithelial cells. Int Immunopharmacol 13(3):292\u2013300. https:\/\/doi.org\/10.1016\/j.intimp.2012.04.007","journal-title":"Int Immunopharmacol"},{"key":"9998_CR12","doi-asserted-by":"publisher","first-page":"153583","DOI":"10.1016\/j.phymed.2021.153583","volume":"87","author":"J Gasparello","year":"2021","unstructured":"Gasparello J, D\u2019Aversa E, Papi C et al (2021) Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3\u20131 cells by exposure to the SARS-CoV-2 Spike protein. Phytomedicine 87:153583. https:\/\/doi.org\/10.1016\/j.phymed.2021.153583","journal-title":"Phytomedicine"},{"issue":"7","key":"9998_CR13","doi-asserted-by":"publisher","first-page":"5571","DOI":"10.1074\/jbc.M410592200","volume":"280","author":"L Guillot","year":"2005","unstructured":"Guillot L, Le Goffic R, Bloch S et al (2005) Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 280(7):5571\u20135580. https:\/\/doi.org\/10.1074\/jbc.M410592200","journal-title":"J Biol Chem"},{"issue":"4\u20135","key":"9998_CR14","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.micinf.2020.04.009","volume":"22","author":"MA Moreno-Eutimio","year":"2020","unstructured":"Moreno-Eutimio MA, L\u00f3pez-Mac\u00edas C, Pastelin-Palacios R (2020) Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7\/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes. Microbes Infect 22(4\u20135):226\u2013229. https:\/\/doi.org\/10.1016\/j.micinf.2020.04.009. Epub 2020 Apr 30","journal-title":"Microbes Infect"},{"issue":"9","key":"9998_CR15","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.3390\/microorganisms9091820","volume":"9","author":"D Bortolotti","year":"2021","unstructured":"Bortolotti D, Gentili V, Rizzo S et al (2021) TLR3 and TLR7 RNA sensor activation during SARS-CoV-2 infection. Microorganisms 9(9):1820. https:\/\/doi.org\/10.3390\/microorganisms9091820","journal-title":"Microorganisms"},{"issue":"8","key":"9998_CR16","doi-asserted-by":"publisher","first-page":"e1004320","DOI":"10.1371\/journal.ppat.1004320","volume":"10","author":"JM Jimenez-Guarde\u00f1o","year":"2014","unstructured":"Jimenez-Guarde\u00f1o JM, Nieto-Torres JL, DeDiego ML et al (2014) The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis. PLoS Pathog 10(8):e1004320. https:\/\/doi.org\/10.1371\/journal.ppat.1004320","journal-title":"PLoS Pathog"},{"issue":"12","key":"9998_CR17","doi-asserted-by":"publisher","first-page":"e12931","DOI":"10.1111\/cpr.12931","volume":"53","author":"Z Zhao","year":"2020","unstructured":"Zhao Z, Zhao Y, Zhou Y et al (2020) Single-cell analysis identified lung progenitor cells in COVID-19 patients. Cell Prolif 53(12):e12931. https:\/\/doi.org\/10.1111\/cpr.12931","journal-title":"Cell Prolif"},{"key":"9998_CR18","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.3389\/fimmu.2020.01205","volume":"11","author":"H Guo-Parke","year":"2020","unstructured":"Guo-Parke H, Linden D, Weldon S et al (2020) Mechanisms of virus-induced airway immunity dysfunction in disease pathogenesis, progression and exacerbation of COPD. Front Immunol 11:1205. https:\/\/doi.org\/10.3389\/fimmu.2020.01205","journal-title":"Front Immunol"},{"key":"9998_CR19","unstructured":"Coronavirus Brazil COVID-19 (2020) Ministry of Health. https:\/\/covid.saude.gov.br. Accessed 2020\u201305\u201308"},{"key":"9998_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19057-5","author":"J Fajnzylber","year":"2020","unstructured":"Fajnzylber J, Regan J, Coxen K et al (2020) SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-020-19057-5","journal-title":"Nat Commun"},{"issue":"5","key":"9998_CR21","doi-asserted-by":"publisher","first-page":"C1318","DOI":"10.1152\/ajpcell.00036.2009","volume":"297","author":"M Iwata","year":"2009","unstructured":"Iwata M, Silva Enciso JE, Greenberg BH (2009) Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme. Am J Physiol Cell Physiol 297(5):C1318\u2013C1329. https:\/\/doi.org\/10.1152\/ajpcell.00036.2009. Epub 2009 Sep 16","journal-title":"Am J Physiol Cell Physiol"},{"key":"9998_CR22","doi-asserted-by":"publisher","first-page":"e70658","DOI":"10.7554\/eLife.70658","volume":"10","author":"MI Barton","year":"2021","unstructured":"Barton MI, MacGowan SA, Kutuzov MA et al (2021) Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetiCSE. Elife 10:e70658. https:\/\/doi.org\/10.7554\/eLife.70658","journal-title":"Elife"},{"key":"9998_CR23","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg3055","author":"NG Davies","year":"2021","unstructured":"Davies NG, Abbott S, Barnard RC et al (2021) Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science. https:\/\/doi.org\/10.1126\/science.abg3055","journal-title":"Science"},{"key":"9998_CR24","doi-asserted-by":"publisher","first-page":"619453","DOI":"10.3389\/fmed.2020.619453","volume":"7","author":"J Yin","year":"2020","unstructured":"Yin J, Kasper B, Petersen F et al (2020) Association of cigarette smoking, COPD, and lung cancer with expression of SARS-CoV-2 entry genes in human airway epithelial cells. Front Med (Lausanne) 7:619453. https:\/\/doi.org\/10.3389\/fmed.2020.619453","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"9998_CR25","doi-asserted-by":"publisher","first-page":"2000688","DOI":"10.1183\/13993003.00688-2020","volume":"55","author":"JM Leung","year":"2020","unstructured":"Leung JM, Yang CX, Tam A et al (2020) ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. Eur Respir J 55(5):2000688. https:\/\/doi.org\/10.1183\/13993003.00688-2020","journal-title":"Eur Respir J"},{"key":"9998_CR26","doi-asserted-by":"publisher","unstructured":"Vardavas CI, Nikitara K (2020) COVID-19 and smoking: a systematic review of the evidence. Tob Induc Dis 18:20. https:\/\/doi.org\/10.18332\/tid\/119324","DOI":"10.18332\/tid\/119324"},{"key":"9998_CR27","doi-asserted-by":"publisher","first-page":"CD010257","DOI":"10.1002\/14651858.CD010257","volume":"12","author":"DJ Vollenweider","year":"2012","unstructured":"Vollenweider DJ, Jarrett H, Steurer-Stey CA et al (2012) Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 12:CD010257. https:\/\/doi.org\/10.1002\/14651858.CD010257","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"9998_CR28","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1080\/19490976.2020.1766345","volume":"11","author":"I Spacova","year":"2020","unstructured":"Spacova I, Van Beeck W, Seys S et al (2020) Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model. Gut Microbes 11(6):1729\u20131744. https:\/\/doi.org\/10.1080\/19490976.2020.1766345","journal-title":"Gut Microbes"},{"issue":"8","key":"9998_CR29","doi-asserted-by":"publisher","first-page":"e0136455","DOI":"10.1371\/journal.pone.0136455","volume":"10","author":"E Mortaz","year":"2015","unstructured":"Mortaz E, Adcock IM, Ricciardolo FL et al (2015) Anti-inflammatory effects of Lactobacillus rhamnosus and Bifidobacterium breve on cigarette smoke activated human macrophages. PLoS ONE 10(8):e0136455. https:\/\/doi.org\/10.1371\/journal.pone.0136455","journal-title":"PLoS ONE"},{"issue":"8","key":"9998_CR30","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00011-015-0837-6","volume":"64","author":"H Zelaya","year":"2015","unstructured":"Zelaya H, Tada A, Vizoso-Pinto MG et al (2015) Nasal priming with immunobiotic Lactobacillus rhamnosus modulates inflammation-coagulation interactions and reduces influenza virus-associated pulmonary damage. Inflamm Res 64(8):589\u2013602. https:\/\/doi.org\/10.1007\/s00011-015-0837-6","journal-title":"Inflamm Res"},{"issue":"15","key":"9998_CR31","doi-asserted-by":"publisher","first-page":"8883","DOI":"10.1111\/jcmm.15574","volume":"24","author":"CW Shi","year":"2020","unstructured":"Shi CW, Zeng Y, Yang GL et al (2020) Effect of Lactobacillus rhamnosus on the development of B cells in gut-associated lymphoid tissue of BALB\/c mice. J Cell Mol Med 24(15):8883\u20138886. https:\/\/doi.org\/10.1111\/jcmm.15574","journal-title":"J Cell Mol Med"},{"issue":"7","key":"9998_CR32","doi-asserted-by":"publisher","first-page":"e38890","DOI":"10.1371\/journal.pone.0038890","volume":"7","author":"Y Huang","year":"2012","unstructured":"Huang Y, Cai B, Xu M et al (2012) Gene silencing of Toll-like receptor 2 inhibits proliferation of human liver cancer cells and secretion of inflammatory cytokines. PLoS ONE 7(7):e38890. https:\/\/doi.org\/10.1371\/journal.pone.0038890","journal-title":"PLoS ONE"},{"issue":"32","key":"9998_CR33","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.3748\/wjg.v17.i32.3745","volume":"17","author":"I Sheyhidin","year":"2011","unstructured":"Sheyhidin I, Nabi G, Hasim A et al (2011) Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma. World J Gastroenterol 17(32):3745\u20133751. https:\/\/doi.org\/10.3748\/wjg.v17.i32.3745","journal-title":"World J Gastroenterol"},{"issue":"1","key":"9998_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3109\/13651501.2013.859708","volume":"18","author":"B Hajebrahimi","year":"2014","unstructured":"Hajebrahimi B, Bagheri M, Hassanshahi G et al (2014) The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals. Int J Psychiatry Clin Pract 18(1):41\u201344. https:\/\/doi.org\/10.3109\/13651501.2013.859708","journal-title":"Int J Psychiatry Clin Pract"},{"issue":"9","key":"9998_CR35","doi-asserted-by":"publisher","first-page":"e45136","DOI":"10.1371\/journal.pone.0045136","volume":"7","author":"F Xing","year":"2012","unstructured":"Xing F, Matsumiya T, Onomoto K et al (2012) Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors. PLoS ONE 7(9):e45136. https:\/\/doi.org\/10.1371\/journal.pone.0045136","journal-title":"PLoS ONE"},{"key":"9998_CR36","doi-asserted-by":"publisher","first-page":"109568","DOI":"10.1016\/j.cbi.2021.109568","volume":"345","author":"KS Alharbi","year":"2021","unstructured":"Alharbi KS, Fuloria NK, Fuloria S et al (2021) Nuclear factor-kappa B and its role in inflammatory lung disease. Chem Biol Interact 345:109568. https:\/\/doi.org\/10.1016\/j.cbi.2021.109568","journal-title":"Chem Biol Interact"},{"key":"9998_CR37","doi-asserted-by":"publisher","first-page":"119090","DOI":"10.1016\/j.lfs.2021.119090","volume":"269","author":"MY Zhang","year":"2021","unstructured":"Zhang MY, Jiang YX, Yang YC et al (2021) Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS\/NLRP3\/caspase-1 pathway. Life Sci 269:119090. https:\/\/doi.org\/10.1016\/j.lfs.2021.119090","journal-title":"Life Sci"},{"issue":"12","key":"9998_CR38","doi-asserted-by":"publisher","first-page":"e1009130","DOI":"10.1371\/journal.ppat.1009130","volume":"16","author":"AM Gamage","year":"2020","unstructured":"Gamage AM, Tan KS, Chan WOY et al (2020) Infection of human nasal epithelial cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles. PLoS Pathog 16(12):e1009130. https:\/\/doi.org\/10.1371\/journal.ppat.1009130","journal-title":"PLoS Pathog"},{"key":"9998_CR39","doi-asserted-by":"publisher","DOI":"10.1101\/2020.09.11.293951","author":"CDSG Pedrosa","year":"2021","unstructured":"Pedrosa CDSG, Goto-Silva L, Temerozo JR et al (2021) Non-permissive SARS-CoV-2 infection in human neurospheres. BioRxiv. https:\/\/doi.org\/10.1101\/2020.09.11.293951","journal-title":"BioRxiv"},{"issue":"12","key":"9998_CR40","doi-asserted-by":"publisher","first-page":"e1009130","DOI":"10.1371\/journal.ppat.1009130","volume":"16","author":"AM Gamage","year":"2020","unstructured":"Gamage AM, Tan KS, Chan WOY et al (2020) Infection of human nasal epithelial cells with SARS-CoV-2 and a 382- nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles. PLoS Pathog 16(12):e1009130. https:\/\/doi.org\/10.1371\/journal.ppat.1009130","journal-title":"PLoS Pathog"},{"issue":"3","key":"9998_CR41","doi-asserted-by":"publisher","first-page":"e20201707","DOI":"10.1084\/jem.20201707","volume":"218","author":"TS Rodrigues","year":"2021","unstructured":"Rodrigues TS, de S\u00e1 KSG, Ishimoto AY et al (2021) Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients. DS. J Exp Med 218(3):e20201707. https:\/\/doi.org\/10.1084\/jem.20201707","journal-title":"DS. J Exp Med"},{"issue":"8","key":"9998_CR42","doi-asserted-by":"publisher","first-page":"e43124","DOI":"10.1371\/journal.pone.0043124","volume":"7","author":"SE Budulac","year":"2012","unstructured":"Budulac SE, Boezen HM, Hiemstra PS et al (2012) Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease. PLoS ONE 7(8):e43124. https:\/\/doi.org\/10.1371\/journal.pone.0043124","journal-title":"PLoS ONE"},{"issue":"33","key":"9998_CR43","doi-asserted-by":"publisher","first-page":"eabb7238","DOI":"10.1126\/sciadv.abb7238","volume":"6","author":"HC Do-Umehara","year":"2020","unstructured":"Do-Umehara HC, Chen C, Zhang Q et al (2020) Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice. Sci Adv 6(33):eabb7238. https:\/\/doi.org\/10.1126\/sciadv.abb7238","journal-title":"Sci Adv."},{"issue":"1","key":"9998_CR44","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s42003-021-02983-5","volume":"5","author":"CJ Neufeldt","year":"2022","unstructured":"Neufeldt CJ, Cerikan B, Cortese M et al (2022) SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-\u03baB. Commun Biol 5(1):45. https:\/\/doi.org\/10.1038\/s42003-021-02983-5","journal-title":"Commun Biol"},{"key":"9998_CR45","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.2147\/COPD.S117652","volume":"11","author":"KM Beeh","year":"2016","unstructured":"Beeh KM, Beier J, Candler H et al (2016) Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype - a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial. Int J Chron Obstruct Pulmon Dis 11:2877\u20132884. https:\/\/doi.org\/10.2147\/COPD.S117652","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"13","key":"9998_CR46","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1001\/jama.2020.170","volume":"324","author":"BM Tomazini","year":"2020","unstructured":"Tomazini BM, Maia IS, Cavalcanti AB, COALITION COVID-19 Brazil III Investigators et al (2020) Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: The CoDEX Randomized Clinical Trial. JAMA 324(13):1307\u20131316. https:\/\/doi.org\/10.1001\/jama.2020.170","journal-title":"JAMA"},{"key":"9998_CR47","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1183\/09031936.00193908","volume":"34","author":"C Crim","year":"2009","unstructured":"Crim C, Calverley PM, Anderson JA et al (2009) Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results. Eur Respir J 34:641\u2013647. https:\/\/doi.org\/10.1183\/09031936.00193908","journal-title":"Eur Respir J"},{"key":"9998_CR48","doi-asserted-by":"publisher","first-page":"CD010115","DOI":"10.1002\/14651858.CD010115.pub2","volume":"10","author":"K Kew","year":"2014","unstructured":"Kew K, Seniukovich A (2014) Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 10:CD010115. https:\/\/doi.org\/10.1002\/14651858.CD010115.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"9998_CR49","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1164\/rccm.200611-1630OC","volume":"176","author":"P Ernst","year":"2007","unstructured":"Ernst P, Gonzalez AV, Brassard P et al (2007) Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia. Am J Respir Crit Care Med 176:162\u2013166. https:\/\/doi.org\/10.1164\/rccm.200611-1630OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"9998_CR50","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jmii.2019.03.002","volume":"52","author":"CT Wu","year":"2019","unstructured":"Wu CT, Lin FH, Lee YT et al (2019) Effect of Lactobacillus rhamnosus GG immunopathologic changes in chronic mouse asthma model. J Microbiol Immunol Infect 52(6):911\u2013919. https:\/\/doi.org\/10.1016\/j.jmii.2019.03.002","journal-title":"J Microbiol Immunol Infect"},{"issue":"3","key":"9998_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12088-021-00949-z","volume":"61","author":"L Zhao","year":"2021","unstructured":"Zhao L, Mao Y, Yu H et al (2021) The preventive effects of Lactobacillus casei on acute lung injury induced by lipopolysaccharide. Indian J Microbiol 61(3):1\u201313. https:\/\/doi.org\/10.1007\/s12088-021-00949-z","journal-title":"Indian J Microbiol"},{"issue":"1","key":"9998_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0954422420000116","volume":"34","author":"SA Jamalkandi","year":"2021","unstructured":"Jamalkandi SA, Ahmadi A, Ahrari I et al (2021) Oral and nasal probiotic administration for the prevention and alleviation of allergic diseases, asthma and chronic obstructive pulmonary disease. Nutr Res Rev 34(1):1\u201316. https:\/\/doi.org\/10.1017\/S0954422420000116","journal-title":"Nutr Res Rev"},{"issue":"8","key":"9998_CR53","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1177\/1060028020983021","volume":"55","author":"T Ji","year":"2021","unstructured":"Ji T, Zhu X, Shang F et al (2021) Preventive effect of probiotics on ventilator-associated pneumonia: a meta-analysis of 2428 patients. Ann Pharmacother 55(8):949\u2013962. https:\/\/doi.org\/10.1177\/1060028020983021","journal-title":"Ann Pharmacother"},{"issue":"4","key":"9998_CR54","doi-asserted-by":"publisher","first-page":"e0225560","DOI":"10.1371\/journal.pone.0225560","volume":"15","author":"JL Carvalho","year":"2020","unstructured":"Carvalho JL, Miranda M, Fialho AK et al (2020) Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl\/6 mice: relevance to inflammatory markers in human bronchial epithelial cells. PLoS ONE 15(4):e0225560. https:\/\/doi.org\/10.1371\/journal.pone.0225560","journal-title":"PLoS ONE"},{"issue":"77","key":"9998_CR55","doi-asserted-by":"publisher","first-page":"100021","DOI":"10.1016\/j.clinsp.2022.100021","volume":"15","author":"F Olimpio","year":"2022","unstructured":"Olimpio F, da Silva JRM, Vieira RP et al (2022) Lacticaseibacillus rhamnosus modulates the inflammatory response and the subsequent lung damage in a murine model of acute lung inflammation. Clinics (Sao Paulo) 15(77):100021. https:\/\/doi.org\/10.1016\/j.clinsp.2022.100021","journal-title":"Clinics (Sao Paulo)"},{"issue":"1","key":"9998_CR56","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1465-9921-15-46","volume":"15","author":"S Sagar","year":"2014","unstructured":"Sagar S, Morgan ME, Chen S et al (2014) Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma. Respir Res 15(1):46. https:\/\/doi.org\/10.1186\/1465-9921-15-46","journal-title":"Respir Res"},{"issue":"4","key":"9998_CR57","doi-asserted-by":"publisher","first-page":"e0231865","DOI":"10.1371\/journal.pone.0231865","volume":"15","author":"L Li","year":"2020","unstructured":"Li L, Fang Z, Liu X et al (2020) Lactobacillus reuteri attenuated allergic inflammation induced by HDM in the mouse and modulated gut microbes. PLoS ONE 15(4):e0231865. https:\/\/doi.org\/10.1371\/journal.pone.0231865","journal-title":"PLoS ONE"},{"issue":"11","key":"9998_CR58","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3390\/life10110260","volume":"10","author":"SW Jin","year":"2020","unstructured":"Jin SW, Lee GH, Jang MJ et al (2020) Lactic acid bacteria ameliorate diesel exhaust particulate matter-exacerbated allergic inflammation in a murine model of asthma. Life (Basel) 10(11):260. https:\/\/doi.org\/10.3390\/life10110260","journal-title":"Life (Basel)"},{"issue":"3","key":"9998_CR59","doi-asserted-by":"publisher","first-page":"150","DOI":"10.4168\/aair.2012.4.3.150","volume":"4","author":"SO Jang","year":"2012","unstructured":"Jang SO, Kim HJ, Kim YJ et al (2012) Asthma prevention by Lactobacillus rhamnosus in a mouse model is associated with CD4(+)CD25(+)Foxp3(+) T cells. Allergy Asthma Immunol Res 4(3):150\u2013156. https:\/\/doi.org\/10.4168\/aair.2012.4.3.150","journal-title":"Allergy Asthma Immunol Res"},{"issue":"2","key":"9998_CR60","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.intimp.2013.06.024","volume":"17","author":"E Chiba","year":"2013","unstructured":"Chiba E, Tomosada Y, Vizoso-Pinto MG et al (2013) Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection. Int Immunopharmacol 17(2):373\u2013382. https:\/\/doi.org\/10.1016\/j.intimp.2013.06.024","journal-title":"Int Immunopharmacol"},{"key":"9998_CR61","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2172-14-40","volume":"14","author":"Y Tomosada","year":"2013","unstructured":"Tomosada Y, Chiba E, Zelaya H et al (2013) Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BMC Immunol 14:40. https:\/\/doi.org\/10.1186\/1471-2172-14-40","journal-title":"BMC Immunol"},{"issue":"1","key":"9998_CR62","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3920\/BM2020.0068","volume":"12","author":"GP DeMuri","year":"2021","unstructured":"DeMuri GP, Lehtoranta LM, Eickhoff JC et al (2021) Ex vivo peripheral blood mononuclear cell response to R848 in children after supplementation with the probiotic Lactobacillus acidophilus NCFM\/Bifidobacterium lactis Bi-07. Benef Microbes 12(1):85\u201393. https:\/\/doi.org\/10.3920\/BM2020.0068","journal-title":"Benef Microbes"},{"issue":"4","key":"9998_CR63","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/foods10040902","volume":"10","author":"W Lu","year":"2021","unstructured":"Lu W, Fang Z, Liu X et al (2021) The potential role of probiotics in protection against influenza a virus infection in mice. Foods 10(4):902. https:\/\/doi.org\/10.3390\/foods10040902","journal-title":"Foods"},{"key":"9998_CR64","doi-asserted-by":"publisher","first-page":"102981","DOI":"10.1016\/j.ebiom.2020.102981","volume":"60","author":"D Groeger","year":"2020","unstructured":"Groeger D, Schiavi E, Grant R et al (2020) Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection. EBioMedicine 60:102981. https:\/\/doi.org\/10.1016\/j.ebiom.2020.102981","journal-title":"EBioMedicine"},{"issue":"1","key":"9998_CR65","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12906-020-02964-x","volume":"20","author":"L Yang","year":"2020","unstructured":"Yang L, Wen M, Liu X et al (2020) Granules ameliorate pulmonary inflammation in the rat model of chronic obstructive pulmonary disease via TLR2\/4-mediated NF-\u03baB pathway. BMC Complement Med Ther 20(1):170. https:\/\/doi.org\/10.1186\/s12906-020-02964-x","journal-title":"BMC Complement Med Ther"},{"issue":"8","key":"9998_CR66","doi-asserted-by":"publisher","first-page":"e0136455","DOI":"10.1371\/journal.pone.0136455","volume":"10","author":"E Mortaz","year":"2015","unstructured":"Mortaz E, Adcock IM, Ricciardolo FL et al (2015) Anti-Inflammatory effects of Lactobacillus rahmnosus and Bifidobacterium breve on cigarette smoke activated human macrophages. PLoS ONE 10(8):e0136455. https:\/\/doi.org\/10.1371\/journal.pone.0136455","journal-title":"PLoS ONE"},{"key":"9998_CR67","doi-asserted-by":"publisher","first-page":"e68563","DOI":"10.7554\/eLife.68563","volume":"10","author":"S Khan","year":"2021","unstructured":"Khan S, Shafiei MS, Longoria C et al (2021) SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-\u03baB pathway. Elife 10:e68563. https:\/\/doi.org\/10.7554\/eLife.68563","journal-title":"Elife"},{"issue":"5","key":"9998_CR68","doi-asserted-by":"publisher","first-page":"e97861","DOI":"10.1371\/journal.pone.0097861","volume":"9","author":"L Khailova","year":"2014","unstructured":"Khailova L, Petrie B, Baird CH, Dominguez Rieg JA, Wischmeyer PE (2014) Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis. PLoS ONE 9(5):e97861. https:\/\/doi.org\/10.1371\/journal.pone.0097861","journal-title":"PLoS ONE"},{"key":"9998_CR69","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8874339","author":"MM Aboudounya","year":"2021","unstructured":"Aboudounya MM, Heads RJ (2021) COVID-19 and Toll-like receptor 4 (TLR4): SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation. Mediators Inflamm. https:\/\/doi.org\/10.1155\/2021\/8874339","journal-title":"Mediators Inflamm"},{"key":"9998_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2020.12.014","volume":"87","author":"K Singh","year":"2021","unstructured":"Singh K, Rao A (2021) A potential immunomodulator in COVID-19 infection management. Nutr Res 87:1\u201312. https:\/\/doi.org\/10.1016\/j.nutres.2020.12.014","journal-title":"Nutr Res"},{"issue":"1\u20132","key":"9998_CR71","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.virusres.2008.03.004","volume":"136","author":"S Wang","year":"2008","unstructured":"Wang S, Guo F, Liu K et al (2008) Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2. Virus Res 136(1\u20132):8\u201315. https:\/\/doi.org\/10.1016\/j.virusres.2008.03.004","journal-title":"Virus Res"},{"key":"9998_CR72","doi-asserted-by":"publisher","first-page":"100306","DOI":"10.1016\/j.jbc.2021.100306","volume":"296","author":"A Bayati","year":"2021","unstructured":"Bayati A, Kumar R, Francis V et al (2021) SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis. J Biol Chem 296:100306. https:\/\/doi.org\/10.1016\/j.jbc.2021.100306","journal-title":"J Biol Chem"},{"issue":"1","key":"9998_CR73","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1186\/s13054-020-03398-0","volume":"24","author":"JF Bermejo-Martin","year":"2020","unstructured":"Bermejo-Martin JF, Gonz\u00e1lez-Rivera M, Almansa R et al (2020) Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19. Crit Care 24(1):691. https:\/\/doi.org\/10.1186\/s13054-020-03398-0","journal-title":"Crit Care"},{"issue":"2","key":"9998_CR74","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1128\/JVI.02202-13","volume":"88","author":"A Heurich","year":"2014","unstructured":"Heurich A, Hofmann-Winkler H, Gierer S et al (2014) TMPRSS2 and ADAM17 cleave ACE2 diferentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J Virol 88(2):1293\u20131307. https:\/\/doi.org\/10.1128\/JVI.02202-13","journal-title":"J Virol"},{"issue":"34","key":"9998_CR75","doi-asserted-by":"publisher","first-page":"30113","DOI":"10.1074\/jbc.M505111200","volume":"280","author":"DW Lambert","year":"2005","unstructured":"Lambert DW, Yarski M, Warner FJ et al (2005) Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem 280(34):30113\u201330119. https:\/\/doi.org\/10.1074\/jbc.M505111200","journal-title":"J Biol Chem"},{"issue":"3","key":"9998_CR76","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.antiviral.2009.12.001","volume":"85","author":"S Haga","year":"2010","unstructured":"Haga S, Nagata N, Okamura T et al (2010) TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res 85(3):551\u2013555. https:\/\/doi.org\/10.1016\/j.antiviral.2009.12.001","journal-title":"Antiviral Res"},{"key":"9998_CR77","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.devcel.2020.05.012","volume":"53","author":"JC Smith","year":"2020","unstructured":"Smith JC, Sausville EL, Girish V et al (2020) Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE-2 in the respiratory tract. Dev Cell 53:514\u2013529. https:\/\/doi.org\/10.1016\/j.devcel.2020.05.012","journal-title":"Dev Cell"},{"key":"9998_CR78","doi-asserted-by":"publisher","first-page":"2001116","DOI":"10.1183\/13993003.01116-2020","volume":"55","author":"P Russo","year":"2020","unstructured":"Russo P, Bonassi S, Giacconi R et al (2020) COVID-19 and smoking. Is nicotine the hidden link Eur Respir J 55:2001116. https:\/\/doi.org\/10.1183\/13993003.01116-2020","journal-title":"Is nicotine the hidden link Eur Respir J"},{"issue":"9","key":"9998_CR79","doi-asserted-by":"publisher","first-page":"6597","DOI":"10.1002\/jcp.30343","volume":"236","author":"MS Adil","year":"2021","unstructured":"Adil MS, Verma A, Rudraraju M et al (2021) Akt-independent effects of triciribine on ACE2 expression in human lung epithelial cells: potential benefits in restricting SARS-CoV2 infection. J Cell Physiol 236(9):6597\u20136606. https:\/\/doi.org\/10.1002\/jcp.30343","journal-title":"J Cell Physiol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-022-09998-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-022-09998-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-022-09998-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T05:28:34Z","timestamp":1701235714000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-022-09998-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,8]]},"references-count":79,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["9998"],"URL":"https:\/\/doi.org\/10.1007\/s12602-022-09998-2","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,8]]},"assertion":[{"value":"28 September 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}