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Prot."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Weizmannia coagulans<\/jats:italic> GBI-30, 6086 (BC30) has previously been shown to increase protein digestion in an in vitro model of the stomach and small intestine and amino acid appearance in healthy men and women after ingestion of milk protein concentrate. The impact of ingesting BC30 with other protein sources or in other demographics is largely unknown. The purpose of this study was to examine the impact of adding BC30 to a 20-g dose of a blend of rice and pea protein on postprandial changes in blood amino acids concentrations in healthy, older women. Healthy, older females (<jats:italic>n<\/jats:italic>\u2009=\u200930, 58.5\u2009\u00b1\u20095.2\u00a0years, 165.4\u2009\u00b1\u20096.8\u00a0cm, 65.6\u2009\u00b1\u20098.8\u00a0kg, 23.7\u2009\u00b1\u20093.2\u00a0kg\/m<jats:sup>2<\/jats:sup>) completed two separate 14-day supplementation protocols separated by a 3-week washout period. Participants were instructed to ingest a 20-g protein dose of a blend of rice and pea protein concentrates (ProDiem Plant Protein Solutions, Kerry) with (PPCBC30) or without (PPC) the addition of 1\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\u00a0CFU BC30 (Kerry). Body composition and demographics were assessed upon arrival to the laboratory. Upon ingestion of their final assigned supplemental dose, blood samples were taken at 0 (baseline), 30-, 60-, 90-, 120-, 180-, and 240-min post-consumption and analyzed for amino acid concentrations. Alanine (<jats:italic>p<\/jats:italic>\u2009=\u20090.018), tryptophan (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), cysteine (<jats:italic>p<\/jats:italic>\u2009=\u20090.041), essential amino acids (<jats:italic>p<\/jats:italic>\u2009=\u20090.050), and total amino acids (<jats:italic>p<\/jats:italic>\u2009=\u20090.039) all exhibited significantly (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05) greater AUC with PPCBC30 when compared to PPC. In addition, tryptophan (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), cysteine (<jats:italic>p<\/jats:italic>\u2009=\u20090.021), essential amino acids (<jats:italic>p<\/jats:italic>\u2009=\u20090.049), and total amino acids (<jats:italic>p<\/jats:italic>\u2009=\u20090.035) displayed significantly greater (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05) concentration maximum (<jats:italic>C<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub>) values in PPCBC30 when compared to PPC. Finally, time to reach <jats:italic>C<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub> (<jats:italic>T<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub>) was similar between conditions with 80% of all measured amino acids and amino acid combinations achieving <jats:italic>C<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub> at a similar time (~\u200960\u00a0min). Only phenylalanine <jats:italic>T<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub> was found to be different (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) between the two conditions with PPC displaying a greater proportion of <jats:italic>T<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub> values after 30\u00a0min. Following qualitative (non-inferential) assessment, 88% of all measured outcomes achieved a higher AUC with PPCBC30 and 100% of all outcomes achieved a higher <jats:italic>C<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub> with PPCBC30. In concert with previous findings in a younger mixed gender cohort with milk protein, the addition of BC30 to a daily 20-g dose of plant protein concentrate in healthy older women improved AUC and <jats:italic>C<\/jats:italic><jats:sub><jats:italic>Max<\/jats:italic><\/jats:sub> values in several individual amino acids and amino acid combinations. Retrospectively registered on April 6, 2022, at ClinicalTrials.gov\u00a0as NCT05313178.<\/jats:p>","DOI":"10.1007\/s12602-022-10028-4","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:02:51Z","timestamp":1670994171000},"page":"125-137","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Probiotic BC30 Improves Amino Acid Absorption from Plant Protein Concentrate in Older Women"],"prefix":"10.1007","volume":"16","author":[{"given":"Kylie E.","family":"Walden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Hagele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan S.","family":"Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen N.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joesi M.","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-7294","authenticated-orcid":false,"given":"Chad M.","family":"Kerksick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"10028_CR1","doi-asserted-by":"publisher","unstructured":"Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document. 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