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(1) The positive rate of SIBO and methane, hsCRP levels in SCH group were higher than those in control group (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), the total score of GSRS scale, mean score of indigestion\u00a0syndrome, and constipation syndrome in SCH group were higher (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). (2) The mean abundance of hydrogen and methane were higher in SCH group. (3) After treatment, serum levels of thyrotropin(TSH), total cholesterol(TC), triglyceride(TG), low-density lipoprotein (LDL), and hsCRP in intervention group were decreased, and high-density lipoprotein (HDL) was increased compared with before treatment (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). (4) After treatment, methane positive rate, total score of GSRS scale, mean score of diarrhea syndrome, dyspepsia syndrome, and constipation syndrome were decreased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). (5) The average abundance of methane and hydrogen were lower. Probiotics combined with prebiotics are effective in the treatment of SIBO in pregnant SCH patients.\n                  <\/jats:p>\n                  <jats:p>Clinical Trial Registration Number: ChiCTR1900026326.<\/jats:p>","DOI":"10.1007\/s12602-023-10068-4","type":"journal-article","created":{"date-parts":[[2023,4,9]],"date-time":"2023-04-09T23:13:32Z","timestamp":1681082012000},"page":"579-588","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Probiotics and Prebiotics in Subclinical Hypothyroidism of Pregnancy with Small Intestinal Bacterial Overgrowth"],"prefix":"10.1007","volume":"16","author":[{"given":"Qian","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongzong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinkai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"issue":"10","key":"10068_CR1","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1089\/thy.2011.0087","volume":"21","author":"A Stagnaro-Green","year":"2011","unstructured":"Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R et al (2011) Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. 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