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The overall isolation percentage was 39% and differentiated serologically into ten different serotypes: O158, O128, O125, O124, O91, O78, O55, O44, O2, and O1. The isolates represented absolute resistance to ampicillin, cefotaxime, and cephalexin. The effectiveness of CE (commercial probiotic product;\u00a0Gro2MAX) on ESBL-producing\u00a0<jats:italic>E. coli\u00a0<\/jats:italic>(O78) isolate transmission and excretion was studied in vivo. The results showed that the CE product has interesting properties, making it an excellent candidate for targeted drug delivery by inhibiting bacterial growth and downregulating biofilm, adhesins, and toxin-associated genes loci. The histopathological findings demonstrated the capability of CE in repairing internal organ tissues. Our outcomes suggested that the administration of CE (probiotic products) in broiler farms could be a safe and alternative approach to control the transmission of ESBL-producing\u00a0virulent <jats:italic>E. coli<\/jats:italic>\u00a0in broiler chickens.<\/jats:p>","DOI":"10.1007\/s12602-023-10095-1","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T02:50:34Z","timestamp":1686019834000},"page":"1087-1098","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Modulatory Effect of Competitive Exclusion on the Transmission of ESBL E. coli in Chickens"],"prefix":"10.1007","volume":"16","author":[{"given":"Amera F.","family":"Ebrahem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-9776","authenticated-orcid":false,"given":"Azza S.","family":"El-Demerdash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania M.","family":"Orady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal M.","family":"Nabil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"10095_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/pathogens10040467","volume":"10","author":"D Kathayat","year":"2021","unstructured":"Kathayat D, Lokesh D, Ranjit S, Rajashekara G (2021) Avian pathogenic Escherichia coli (APEC): an overview of virulence and pathogenesis factors, zoonotic potential, and control strategies. 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