{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:52:48Z","timestamp":1793195568424,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"crossref","award":["88882.430751\/2019-01"],"award-info":[{"award-number":["88882.430751\/2019-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12602-023-10167-2","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:01:51Z","timestamp":1697274111000},"page":"588-605","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Lactobacillus rhamnosus Modulates Lung Inflammation and Mitigates Gut Dysbiosis in a Murine Model of Asthma-COPD Overlap Syndrome"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-9965","authenticated-orcid":false,"given":"J\u00e9ssica Aparecida","family":"Vasconcelos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-5297","authenticated-orcid":false,"given":"Amanda Sodre","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-3904","authenticated-orcid":false,"given":"Fabiana","family":"Ol\u00edmpio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-056X","authenticated-orcid":false,"given":"Paloma Cristina","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-9167","authenticated-orcid":false,"given":"Nilsa","family":"Damaceno-Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-1143","authenticated-orcid":false,"given":"Rodolfo","family":"de Paula Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-0651","authenticated-orcid":false,"given":"Carla Romano","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-541X","authenticated-orcid":false,"given":"Flavio","family":"Aimbire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"10167_CR1","unstructured":"GINA-GOLD (2015) Asthma, COPD and asthma-COPD overlap syndrome (ACOS). Available at: http:\/\/www.goldcopd.org\/asthma-copd-overlap.html. Accessed 18 Jun 2023"},{"key":"10167_CR2","doi-asserted-by":"publisher","unstructured":"Habener A, Happle C, Grychtol R et al (2021) Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model. J Allergy Clin Immunol 147(6):2281\u20132294.e7. https:\/\/doi.org\/10.1016\/j.jaci.2020.09.041","DOI":"10.1016\/j.jaci.2020.09.041"},{"key":"10167_CR3","first-page":"76","volume":"50","author":"JL Cai","year":"2010","unstructured":"Cai JL, Wang HL, Wang AP (2010) Relationship between mmp-1 genetic polymorphism with the susceptibility of COPD of 80 Han nationality in Jiangxi province. Shandong Medical Journal 50:76\u201377","journal-title":"Shandong Medical Journal"},{"key":"10167_CR4","doi-asserted-by":"publisher","unstructured":"Leung JM, Sin DD (2017) Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets. BMJ 358:j3772. https:\/\/doi.org\/10.1136\/bmj.j3772","DOI":"10.1136\/bmj.j3772"},{"key":"10167_CR5","doi-asserted-by":"publisher","unstructured":"Ding B, Enstone A et al (2016) Asthma and chronic obstructive pulmonary disease overlap syndrome (ACOS): structured literature review and physician insights. Expert Rev Respir Med 10(3):363\u201371. https:\/\/doi.org\/10.1586\/17476348.2016.1144476","DOI":"10.1586\/17476348.2016.1144476"},{"key":"10167_CR6","doi-asserted-by":"publisher","unstructured":"Hirai K, Shirai T, Suzuki M et al (2017) A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype. Clin Exp Allergy 47(11):1374\u20131382. https:\/\/doi.org\/10.1111\/cea.12970","DOI":"10.1111\/cea.12970"},{"key":"10167_CR7","doi-asserted-by":"publisher","unstructured":"Lu Y, Kared H, Tan SW et al (2018) Dynamics of helper CD4 T cells during acute and stable allergic asthma. Mucosal Immunol 11(6):1640\u20131652. https:\/\/doi.org\/10.1038\/s41385-018-0057-9","DOI":"10.1038\/s41385-018-0057-9"},{"key":"10167_CR8","doi-asserted-by":"publisher","unstructured":"Barnes PJ (2016) Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 138(1):16\u201327. https:\/\/doi.org\/10.1016\/j.jaci.2016.05.011","DOI":"10.1016\/j.jaci.2016.05.011"},{"key":"10167_CR9","doi-asserted-by":"publisher","unstructured":"Yang CH, Tian JJ, Ko WS et al (2019) Oligo-fucoidan improved unbalance the Th1\/Th2 and Treg\/Th17 ratios in asthmatic patients: an ex vivo study. Exp Ther Med 17(1):3\u201310. https:\/\/doi.org\/10.3892\/etm.2018.6939","DOI":"10.3892\/etm.2018.6939"},{"key":"10167_CR10","doi-asserted-by":"publisher","unstructured":"Silva LEF, Louren\u00e7o JD, Silva KR et al (2020) Th17\/Treg imbalance in COPD development: suppressors of cytokine signaling and signal transducers and activators of transcription proteins. Sci Rep 10(1):15287. https:\/\/doi.org\/10.1038\/s41598-020-72305-y","DOI":"10.1038\/s41598-020-72305-y"},{"key":"10167_CR11","doi-asserted-by":"publisher","unstructured":"Ma P, Li S, Yang H et al (2021) Comparative RNA-Seq transcriptome analysis on pulmonary inflammation in a mouse model of asthma-COPD overlap syndrome. Front Cell Dev Biol 25(9):628957. https:\/\/doi.org\/10.3389\/fcell.2021.628957","DOI":"10.3389\/fcell.2021.628957"},{"key":"10167_CR12","doi-asserted-by":"publisher","unstructured":"Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383:787\u201393. https:\/\/doi.org\/10.1038\/383787a0","DOI":"10.1038\/383787a0"},{"key":"10167_CR13","doi-asserted-by":"publisher","unstructured":"Lighvani AA, Frucht DM, Jankovic D et al (2001) T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci USA 98(26):15137\u201342. https:\/\/doi.org\/10.1073\/pnas.261570598","DOI":"10.1073\/pnas.261570598"},{"key":"10167_CR14","doi-asserted-by":"publisher","unstructured":"Kannan AK, Sahu N, Mohanan S et al (2013) IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-\u03b3 in naive CD4+ T cells. J Allergy Clin Immunol 132(4):811\u201320.e1\u20135. https:\/\/doi.org\/10.1016\/j.jaci.2013.04.033","DOI":"10.1016\/j.jaci.2013.04.033"},{"key":"10167_CR15","doi-asserted-by":"publisher","unstructured":"Rhee CK (2015) Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome. Korean J Intern Med 30(4):443\u2013449. https:\/\/doi.org\/10.3904\/kjim.2015.30.4.443","DOI":"10.3904\/kjim.2015.30.4.443"},{"key":"10167_CR16","doi-asserted-by":"publisher","unstructured":"Bullens DM, Truyen E, Coteur L et al (2006) IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res 3;7(1):135. https:\/\/doi.org\/10.1186\/1465-9921-7-135","DOI":"10.1186\/1465-9921-7-135"},{"key":"10167_CR17","doi-asserted-by":"publisher","unstructured":"Gurczynski SJ and Moore BB (2018) IL-17 in the lung: the good, the bad, and the ugly. Am J Physiol Lung Cell Mol Physiol 1;314(1):L6\u2013L16. https:\/\/doi.org\/10.1152\/ajplung.00344.2017","DOI":"10.1152\/ajplung.00344.2017"},{"key":"10167_CR18","doi-asserted-by":"publisher","unstructured":"Lo CY, Huang HY, He JR et al (2018) Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline. Int J Chron Obstruct Pulmon Dis 13:1135\u20131144. https:\/\/doi.org\/10.2147\/COPD.S161257","DOI":"10.2147\/COPD.S161257"},{"key":"10167_CR19","doi-asserted-by":"publisher","unstructured":"Koo HK, Hong Y, Lim MN et al (2016) Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity. Int J Chron Obstruct Pulmon Dis 11:1129\u201337. https:\/\/doi.org\/10.2147\/COPD.S103281","DOI":"10.2147\/COPD.S103281"},{"key":"10167_CR20","doi-asserted-by":"publisher","unstructured":"Duan MC, Zhang JQ, Liang Y et al (2016) Infiltration of IL-17-producing T cells and Treg cells in a mouse model of smoke-induced emphysema. Inflammation 39(4):1334\u201344. https:\/\/doi.org\/10.1007\/s10753-016-0365-8","DOI":"10.1007\/s10753-016-0365-8"},{"key":"10167_CR21","doi-asserted-by":"publisher","unstructured":"Huang AX, Lu LW, Liu WJ et al (2016) Plasma inflammatory cytokine IL-4, IL-8, IL-10, and TNF-\u03b1 levels correlate with pulmonary function in patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome. Med Sci Monit 22:2800\u20138. https:\/\/doi.org\/10.12659\/msm.896458","DOI":"10.12659\/msm.896458"},{"key":"10167_CR22","doi-asserted-by":"publisher","unstructured":"Chakir J, Shannon J, Molet S et al (2003) Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 111(6):1293\u20138. https:\/\/doi.org\/10.1067\/mai.2003.1557","DOI":"10.1067\/mai.2003.1557"},{"key":"10167_CR23","doi-asserted-by":"publisher","unstructured":"Menezes AMB, Montes de Oca M, P\u00e9rez-Padilla R et al (2014) Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest 145(2):297\u2013304. https:\/\/doi.org\/10.1378\/chest.13-0622","DOI":"10.1378\/chest.13-0622"},{"key":"10167_CR24","doi-asserted-by":"publisher","unstructured":"Kauppi P, Kupiainen H, Lindqvist A et al (2011) Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma 48(3):279\u201385. https:\/\/doi.org\/10.3109\/02770903.2011.555576","DOI":"10.3109\/02770903.2011.555576"},{"key":"10167_CR25","doi-asserted-by":"publisher","unstructured":"Feleszko W, Jaworska J, Rha RD et al (2007) Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy 37(4):498\u2013505. https:\/\/doi.org\/10.1111\/j.1365-2222.2006.02629.x","DOI":"10.1111\/j.1365-2222.2006.02629.x"},{"key":"10167_CR26","doi-asserted-by":"publisher","unstructured":"Rao AV, Bested AC, Beaulne TM et al (2009) A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathogens 1(1):6. https:\/\/doi.org\/10.1186\/1757-4749-1-6","DOI":"10.1186\/1757-4749-1-6"},{"key":"10167_CR27","doi-asserted-by":"publisher","unstructured":"Curciarello R, Canziani KE, Salto I et al (2021) Probiotic lactobacilli isolated from kefir promote down-regulation of inflammatory lamina propria T cells from patients with active IBD. Front Pharmacol 12:658026. https:\/\/doi.org\/10.3389\/fphar.2021.658026","DOI":"10.3389\/fphar.2021.658026"},{"key":"10167_CR28","doi-asserted-by":"publisher","unstructured":"Brzostek D, Kokot M (2014) Asthma-chronic obstructive pulmonary disease overlap syndrome in Poland. Findings of an epidemiological study. Postepy Dermatol Alergol 31(6):372\u20139. https:\/\/doi.org\/10.5114\/pdia.2014.47120","DOI":"10.5114\/pdia.2014.47120"},{"key":"10167_CR29","first-page":"76","volume":"50","author":"JL Cai","year":"2010","unstructured":"Cai JL, Wang HL, Wang AP (2010) Relationship between mmp-1 genetic polymorphism with the susceptibility of COPD of 80 Han nationality in Jiangxi province. Shandong Medical Journal 50:76\u201377","journal-title":"Shandong Medical J"},{"key":"10167_CR30","doi-asserted-by":"publisher","unstructured":"Pouwels SD, Zijlstra GJ, van der Toorn M et al (2016) Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol 310(4):L377\u201386. https:\/\/doi.org\/10.1152\/ajplung.00174.2015","DOI":"10.1152\/ajplung.00174.2015"},{"key":"10167_CR31","doi-asserted-by":"publisher","unstructured":"Suzuki Y, Aono Y, Akiyama N et al (2022) Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma. Autophagy 18(9):2216\u20132228. https:\/\/doi.org\/10.1080\/15548627.2022.2025571","DOI":"10.1080\/15548627.2022.2025571"},{"key":"10167_CR32","doi-asserted-by":"publisher","unstructured":"Kumar S, Lanckacker E, Dentener M et al (2016) Aggravation of allergic airway inflammation by cigarette smoke in mice is CD44-dependent. PLoS One 11(3):e0151113. https:\/\/doi.org\/10.1371\/journal.pone.0151113","DOI":"10.1371\/journal.pone.0151113"},{"key":"10167_CR33","doi-asserted-by":"publisher","unstructured":"Branchett WJ, Walker SA, Lloyd CM (2021) Experimental mouse models of asthma and analysis of CD4 T cells. Methods Mol Biol 2285:329\u2013348. https:\/\/doi.org\/10.1007\/978-1-0716-1311-5_25","DOI":"10.1007\/978-1-0716-1311-5_25"},{"key":"10167_CR34","doi-asserted-by":"publisher","unstructured":"Hodge G, Jersmann H, Tran HB et al (2022) COPD is associated with increased pro-inflammatory CD28null CD8 T and NKT-like cells in the small airways. Clin Exp Immunol 207(3):351\u2013359. https:\/\/doi.org\/10.1093\/cei\/uxab037","DOI":"10.1093\/cei\/uxab037"},{"key":"10167_CR35","doi-asserted-by":"publisher","unstructured":"Rahimi RA, Nepal K, Cetinbas M et al (2020) Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease. J Exp Med 217(9):e20190865. https:\/\/doi.org\/10.1084\/jem.20190865","DOI":"10.1084\/jem.20190865"},{"issue":"7","key":"10167_CR36","first-page":"7661","volume":"8","author":"X Yun","year":"2015","unstructured":"Yun X, Shang Y, Li M (2015) Effect of Lactobacillus salivarius on Th1\/Th2 cytokines and the number of spleen CD4+ CD25+ Foxp3+ Treg in asthma Balb\/c mouse. Int J Clin Exp Pathol 8(7):7661\u20137674. PMID: 26339333","journal-title":"Int J Clin Exp Pathol"},{"key":"10167_CR37","doi-asserted-by":"publisher","unstructured":"Anatriello E, Cunha M, Nogueira J et al (2019) Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: relevance to the Th1\/Th2 cytokines and STAT6\/T-bet. Cell Immunol 341:103928. https:\/\/doi.org\/10.1016\/j.cellimm.2019.103928","DOI":"10.1016\/j.cellimm.2019.103928"},{"key":"10167_CR38","doi-asserted-by":"publisher","unstructured":"Malaviya R, Zhou Z, Raymond H et al (2021) Repeated exposure of house dust mite induces progressive airway inflammation in mice: differential roles of CCL17 and IL-13. Pharmacol Res Perspect 9(3):e00770. https:\/\/doi.org\/10.1002\/prp2.770","DOI":"10.1002\/prp2.770"},{"key":"10167_CR39","doi-asserted-by":"publisher","unstructured":"Firszt R, Francisco D, Church TD et al (2014) Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-\u03b21 in airway fibroblasts in asthma. Eur Respir J 43(2):464\u201373. https:\/\/doi.org\/10.1183\/09031936.00068712","DOI":"10.1183\/09031936.00068712"},{"key":"10167_CR40","doi-asserted-by":"publisher","unstructured":"Shang Q, Zhu L, Shang W et al (2022) Dioscin exhibits protective effects on in vivo and in vitro asthma models via suppressing TGF-\u03b21\/Smad2\/3 and AKT pathways. J Biochem Mol Toxicol 36(8):e23084. https:\/\/doi.org\/10.1002\/jbt.23084","DOI":"10.1002\/jbt.23084"},{"key":"10167_CR41","doi-asserted-by":"publisher","unstructured":"Jung DH, Lee A, Hwang YH et al (2023) Therapeutic effects of Pulsatilla koreana Nakai extract on ovalbumin-induced allergic rhinitis by inhibition of Th2 cell activation and differentiation via the IL-4\/STAT6\/GATA3 pathway. Biomed Pharmacother 162:114730. https:\/\/doi.org\/10.1016\/j.biopha.2023.114730","DOI":"10.1016\/j.biopha.2023.114730"},{"key":"10167_CR42","doi-asserted-by":"publisher","unstructured":"El-Mezayen RE, Matsumoto T (2004) In vitro responsiveness to IL-18 in combination with IL-12 or IL-2 by PBMC from patients with bronchial asthma and atopic dermatitis. Clin Immunol 111(1):61\u20138. https:\/\/doi.org\/10.1016\/j.clim.2003.12.006","DOI":"10.1016\/j.clim.2003.12.006"},{"key":"10167_CR43","doi-asserted-by":"publisher","unstructured":"Wang Z, Ji N, Chen Z et al (2020) MiR-1165\u20133p Suppresses Th2 differentiation via targeting IL-13 and PPM1A in a mouse model of allergic airway inflammation.  Allergy Asthma Immunol Res 12(5):859\u2013876. https:\/\/doi.org\/10.4168\/aair.2020.12.5.859","DOI":"10.4168\/aair.2020.12.5.859"},{"key":"10167_CR44","doi-asserted-by":"publisher","unstructured":"Verma AK, Pandey AK, Singh A et al (2022) Increased serum levels of matrix-metalloproteinase-9, cyclo-oxygenase-2 and prostaglandin E-2 in patients with chronic obstructive pulmonary disease (COPD). Indian J Clin Biochem 37(2):169\u2013177. https:\/\/doi.org\/10.1007\/s12291-021-00973-2","DOI":"10.1007\/s12291-021-00973-2"},{"key":"10167_CR45","doi-asserted-by":"publisher","unstructured":"Carvalho JL, Miranda M, Fialho AK et al (2020) Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced\u00a0COPD\u00a0in C57Bl\/6 mice: relevance to inflammatory markers in human bronchial epithelial cells. PLoS One 24(4):e0225560. https:\/\/doi.org\/10.1371\/journal.pone.0225560","DOI":"10.1371\/journal.pone.0225560"},{"key":"10167_CR46","doi-asserted-by":"publisher","unstructured":"Selman M, Cisneros-Lira J, Gaxiola M et al (2003) Matrix mielloproteinases inhibition attenuates tobacco smoke-induced emphysema in guinea pigs. Chest 123:1633\u201341. https:\/\/doi.org\/10.1378\/chest.123.5.1633","DOI":"10.1378\/chest.123.5.1633"},{"key":"10167_CR47","doi-asserted-by":"publisher","unstructured":"Barnes PJ (2008) Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8(3):183\u201392. https:\/\/doi.org\/10.1038\/nri2254","DOI":"10.1038\/nri2254"},{"key":"10167_CR48","doi-asserted-by":"publisher","unstructured":"Yang L, Zheng Y, Miao YM et al (2022) Bergenin, a PPAR\u03b3 agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis. Acta Pharmacol Sin 43(4):963\u2013976. https:\/\/doi.org\/10.1038\/s41401-021-00717-1","DOI":"10.1038\/s41401-021-00717-1"},{"key":"10167_CR49","doi-asserted-by":"publisher","unstructured":"Reece SW, Varikuti S, Kilburg-Basnyat B et al (2021) Scavenger receptor BI attenuates IL-17A-dependent neutrophilic inflammation in asthma. Am J Respir Cell Mol Biol 64(6):698\u2013708. https:\/\/doi.org\/10.1165\/rcmb.2020-0007OC","DOI":"10.1165\/rcmb.2020-0007OC"},{"key":"10167_CR50","doi-asserted-by":"publisher","unstructured":"Lu LF, Thai TH, Calado DP et al (2009) Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 16;30(1):80\u201391. https:\/\/doi.org\/10.1016\/j.immuni.2008.11.010","DOI":"10.1016\/j.immuni.2008.11.010"},{"key":"10167_CR51","doi-asserted-by":"publisher","unstructured":"Song J, Li Y, Li J et al (2020) Lactobacillus rhamnosus 2016SWU.05.0601 regulates immune balance in ovalbumin-sensitized mice by modulating expression of the immune-related transcription factors and gut microbiota. J Sci Food Agric 100(13):4930\u20134939. https:\/\/doi.org\/10.1002\/jsfa.10554","DOI":"10.1002\/jsfa.10554"},{"key":"10167_CR52","doi-asserted-by":"publisher","unstructured":"Chen W, Ten Dijke P (2016) Immunoregulation by members of the TGF\u03b2 superfamily. Nat Rev Immunol 25;16(12):723\u2013740. https:\/\/doi.org\/10.1038\/nri.2016.112","DOI":"10.1038\/nri.2016.112"},{"key":"10167_CR53","doi-asserted-by":"publisher","unstructured":"Zheng X, Zhang L, Chen J et al (2018) Dendritic cells and Th17\/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease. Biomed Pharmacother 108:1141\u20131151. https:\/\/doi.org\/10.1016\/j.biopha.2018.09.113","DOI":"10.1016\/j.biopha.2018.09.113"},{"key":"10167_CR54","doi-asserted-by":"publisher","unstructured":"Zhou Y, Zhao H, Wang T et al (2022) Anti-inflammatory and anti-asthmatic effects of TMDCT decoction in eosinophilic asthma through Treg\/Th17 balance. Front Pharmacol 13:819728. https:\/\/doi.org\/10.3389\/fphar.2022.819728","DOI":"10.3389\/fphar.2022.819728"},{"key":"10167_CR55","doi-asserted-by":"publisher","unstructured":"Oliveira CR, Carvalho J, Ol\u00edmpio F et al (2023) Transfer factors peptides (Imuno TF\u00ae) modulate the lung inflammation and airway remodeling in allergic asthma. Front Immunol 13:1030252. https:\/\/doi.org\/10.3389\/fimmu.2022.1030252","DOI":"10.3389\/fimmu.2022.1030252"},{"key":"10167_CR56","doi-asserted-by":"publisher","unstructured":"Keely S, Talley NJ, Hansbro PM (2012) Pulmonary-intestinal cross-talk in mucosal inflammatory disease. Mucosal Immunol 5(1):7\u201318. https:\/\/doi.org\/10.1038\/mi.2011.55","DOI":"10.1038\/mi.2011.55"},{"key":"10167_CR57","doi-asserted-by":"publisher","unstructured":"Herp S, Brugiroux S, Garzetti D et al (2019) Mucispirillum schaedleri antagonizes Salmonella virulence to protect mice against colitis. Cell Host Microbe 8;25(5):681\u2013694.e8. https:\/\/doi.org\/10.1016\/j.chom.2019.03.004","DOI":"10.1016\/j.chom.2019.03.004"},{"key":"10167_CR58","doi-asserted-by":"publisher","unstructured":"Raftery AL, Tsantikos E, Harris NL et al (2020) Links between inflammatory bowel disease and chronic obstructive pulmonary disease. Frontiers Immunol 11;11:2144. https:\/\/doi.org\/10.3389\/fimmu.2020.02144","DOI":"10.3389\/fimmu.2020.02144"},{"key":"10167_CR59","doi-asserted-by":"publisher","unstructured":"Bunker JJ, Flynn TM, Koval JC et al (2015) Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A. Immunity 15;43(3):541\u201353. https:\/\/doi.org\/10.1016\/j.immuni.2015.08.007","DOI":"10.1016\/j.immuni.2015.08.007"},{"key":"10167_CR60","doi-asserted-by":"publisher","unstructured":"Bachert C, Humbert M, Hanania NA et al (2020) Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge. Eur Respir J 3;55(4):1901592. https:\/\/doi.org\/10.1183\/13993003.01592-2019","DOI":"10.1183\/13993003.01592-2019"},{"key":"10167_CR61","doi-asserted-by":"publisher","unstructured":"Davis MF, Ludwig S, Brigham EP et al (2018) Effect of home exposure to Staphylococcus aureus on asthma in adolescents. J Allergy Clin Immunol 141(1):402\u2013405.e10. https:\/\/doi.org\/10.1016\/j.jaci.2017.06.031","DOI":"10.1016\/j.jaci.2017.06.031"},{"key":"10167_CR62","doi-asserted-by":"publisher","unstructured":"Dzoro S, Mittermann I, Resch-Marat Y et al (2018) House dust mites as potential carriers for IgE sensitization to bacterial antigens. Allergy 73(1):115\u2013124. https:\/\/doi.org\/10.1111\/all.13260","DOI":"10.1111\/all.13260"},{"key":"10167_CR63","doi-asserted-by":"publisher","unstructured":"Liu C, Yang L, Han Y et al (2019) Mast cells participate in regulation of lung-gut axis during Staphylococcus aureus pneumonia. Cell Prolif 52(2):e12565. https:\/\/doi.org\/10.1111\/cpr.12565","DOI":"10.1111\/cpr.12565"},{"key":"10167_CR64","doi-asserted-by":"publisher","unstructured":"Hand TW, Vujkovic-Cvijin I, Ridaura VK et al (2016) Linking the microbiota, chronic disease, and the immune system. Trends Endocrinol Metab 27(12):831\u2013843. https:\/\/doi.org\/10.1016\/j.tem.2016.08.003","DOI":"10.1016\/j.tem.2016.08.003"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-023-10167-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-023-10167-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-023-10167-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T13:27:24Z","timestamp":1742477244000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-023-10167-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,14]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10167"],"URL":"https:\/\/doi.org\/10.1007\/s12602-023-10167-2","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,14]]},"assertion":[{"value":"18 September 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}