{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:33:40Z","timestamp":1790354020665,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s12602-023-10185-0","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:02:05Z","timestamp":1698109325000},"page":"875-883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Understanding Osteoporosis: Human Bone Density, Genetic Mechanisms, Gut Microbiota, and Future Prospects"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-8630","authenticated-orcid":false,"given":"Jayesh J.","family":"Ahire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Rohilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"10185_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1177\/1759720X11430858","volume":"4","author":"O Demontiero","year":"2012","unstructured":"Demontiero O, Vidal C, Duque G (2012) Aging and bone loss: new insights for the clinician. Ther Adv Musculoskelet Dis 4:61\u201376. https:\/\/doi.org\/10.1177\/1759720X11430858","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10185_CR2","unstructured":"Office of the Surgeon General (US) (2004) Bone health and osteoporosis: a report of the surgeon general. Rockville (MD): Office of the Surgeon General (US) 2004"},{"key":"10185_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","volume":"4","author":"T Sozen","year":"2017","unstructured":"Sozen T, Ozisik L, Calik Basaran N (2017) An overview and management of osteoporosis. Eur J Rheumatol 4:46\u201356. https:\/\/doi.org\/10.5152\/eurjrheum.2016.048","journal-title":"Eur J Rheumatol"},{"key":"10185_CR4","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.2147\/TCRM.S138000","volume":"14","author":"F Pouresmaeili","year":"2018","unstructured":"Pouresmaeili F, Kamalidehghan B, Kamarehei M, Goh YM (2018) A comprehensive overview on osteoporosis and its risk factors. Ther Clin Risk Manag 14:2029\u20132049. https:\/\/doi.org\/10.2147\/TCRM.S138000","journal-title":"Ther Clin Risk Manag"},{"key":"10185_CR5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1152\/physiol.00061.2014","volume":"31","author":"JA Siddiqui","year":"2016","unstructured":"Siddiqui JA, Partridge NC (2016) Physiological bone remodeling: systemic regulation and growth factor involvement. Physiology 31:233\u2013245. https:\/\/doi.org\/10.1152\/physiol.00061.2014","journal-title":"Physiology"},{"key":"10185_CR6","first-page":"92","volume":"43","author":"KN Tu","year":"2018","unstructured":"Tu KN, Lie JD, Wan CKV et al (2018) Osteoporosis: a review of treatment options. Pharm Ther 43:92\u2013104","journal-title":"Pharm Ther"},{"key":"10185_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13018-021-02821-8","volume":"16","author":"N Salari","year":"2021","unstructured":"Salari N, Darvishi N, Bartina Y et al (2021) Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis. J Orthop Surg Res 16:1\u201313. https:\/\/doi.org\/10.1186\/s13018-021-02821-8","journal-title":"J Orthop Surg Res"},{"key":"10185_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.maturitas.2020.05.004","volume":"138","author":"S Rozenberg","year":"2020","unstructured":"Rozenberg S, Bruy\u00e8re O, Bergmann P et al (2020) How to manage osteoporosis before the age of 50. Maturitas 138:14\u201325. https:\/\/doi.org\/10.1016\/j.maturitas.2020.05.004","journal-title":"Maturitas"},{"key":"10185_CR9","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.5534\/WJMH.200099","volume":"38","author":"M De Martinis","year":"2020","unstructured":"De Martinis M, Sirufo MM, Polsinelli M et al (2020) Gender differences in osteoporosis: a single-center observational study. World J Mens Health 38:2287\u20134690. https:\/\/doi.org\/10.5534\/WJMH.200099","journal-title":"World J Mens Health"},{"key":"10185_CR10","doi-asserted-by":"publisher","unstructured":"Alswat KA (2017) Gender disparities in osteoporosis. J Clin Med Res 9:382\u2013387. https:\/\/doi.org\/10.14740\/jocmr2970w","DOI":"10.14740\/jocmr2970w"},{"key":"10185_CR11","doi-asserted-by":"publisher","unstructured":"Bj\u00f6rnsdottir S, Clarke BL, Mannstadt M, Langdahl BL (2022) Male osteoporosis-what are the causes, diagnostic challenges, and management. Best Pract Res Clin Rheumatol 36. https:\/\/doi.org\/10.1016\/j.berh.2022.101766","DOI":"10.1016\/j.berh.2022.101766"},{"key":"10185_CR12","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","volume":"33","author":"MS LeBoff","year":"2022","unstructured":"LeBoff MS, Greenspan SL, Insogna KL et al (2022) The clinician\u2019s guide to prevention and treatment of osteoporosis. Osteoporos Int 33:2049\u20132102. https:\/\/doi.org\/10.1007\/s00198-021-05900-y","journal-title":"Osteoporos Int"},{"key":"10185_CR13","unstructured":"Release notice (2021) Osteoporosis and related fractures in Canada: report from the Canadian Chronic Disease Surveillance System 2020"},{"key":"10185_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2020.600181","volume":"8","author":"J Hou","year":"2020","unstructured":"Hou J, He C, He W et al (2020) Obesity and bone health: a complex link. Front Cell Dev Biol 8:1\u201316. https:\/\/doi.org\/10.3389\/fcell.2020.600181","journal-title":"Front Cell Dev Biol"},{"key":"10185_CR15","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1002\/jbmr.4417","volume":"36","author":"SE Noel","year":"2021","unstructured":"Noel SE, Santos MP, Wright NC (2021) Racial and ethnic disparities in bone health and outcomes in the United States. J Bone Miner Res 36:1881\u20131905. https:\/\/doi.org\/10.1002\/jbmr.4417","journal-title":"J Bone Miner Res"},{"key":"10185_CR16","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1007\/s11999-011-1863-5","volume":"469","author":"JA Cauley","year":"2011","unstructured":"Cauley JA (2011) Defining ethnic and racial differences in osteoporosis and fragility fractures. Clin Orthop Relat Res 469:1891\u20131899. https:\/\/doi.org\/10.1007\/s11999-011-1863-5","journal-title":"Clin Orthop Relat Res"},{"key":"10185_CR17","doi-asserted-by":"publisher","first-page":"e337","DOI":"10.1016\/S2542-5196(17)30136-5","volume":"1","author":"D Prada","year":"2017","unstructured":"Prada D, Zhong J, Colicino E et al (2017) Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies. Lancet Planet Heal 1:e337\u2013e347. https:\/\/doi.org\/10.1016\/S2542-5196(17)30136-5","journal-title":"Lancet Planet Heal"},{"key":"10185_CR18","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s40615-019-00569-w","volume":"6","author":"NC Wright","year":"2019","unstructured":"Wright NC, Melton ME, Sohail M et al (2019) Race plays a role in the knowledge, attitudes, and beliefs of women with osteoporosis. J Racial Ethn Heal Disparities 6:707\u2013718. https:\/\/doi.org\/10.1007\/s40615-019-00569-w","journal-title":"J Racial Ethn Heal Disparities"},{"key":"10185_CR19","doi-asserted-by":"publisher","unstructured":"F\u00f6ger-Samwald U, Dovjak P, Azizi-Semrad U et al (2020) Osteoporosis: pathophysiology and therapeutic options. Excli J 19:1017\u20131037. https:\/\/doi.org\/10.17179\/excli2020-2591","DOI":"10.17179\/excli2020-2591"},{"key":"10185_CR20","doi-asserted-by":"publisher","unstructured":"Marini F, Brandi ML (2010) Genetic determinants of osteoporosis: common bases to cardiovascular diseases? Int J Hypertens 2010. https:\/\/doi.org\/10.4061\/2010\/394579","DOI":"10.4061\/2010\/394579"},{"key":"10185_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2019.00070","volume":"10","author":"RE M\u00e4kitie","year":"2019","unstructured":"M\u00e4kitie RE, Costantini A, K\u00e4mpe A et al (2019) New insights into monogenic causes of osteoporosis. Front Endocrinol 10:1\u201315. https:\/\/doi.org\/10.3389\/fendo.2019.00070","journal-title":"Front Endocrinol"},{"key":"10185_CR22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bone.2019.04.005","volume":"126","author":"K Trajanoska","year":"2019","unstructured":"Trajanoska K, Rivadeneira F (2019) The genetic architecture of osteoporosis and fracture risk. Bone 126:2\u201310. https:\/\/doi.org\/10.1016\/j.bone.2019.04.005","journal-title":"Bone"},{"issue":"1","key":"10185_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41413-021-00143-3","volume":"9","author":"X Zhu","year":"2021","unstructured":"Zhu X, Bai W, Zheng H (2021) Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications. Bone Res 9(1):23. https:\/\/doi.org\/10.1038\/s41413-021-00143-3","journal-title":"Bone Res"},{"key":"10185_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature14878","volume":"526","author":"Z Hou-Feng","year":"2015","unstructured":"Hou-Feng Z, Vincenzo F, Yi-Hsiang H et al (2015) Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature 526:112\u2013117. https:\/\/doi.org\/10.1038\/nature14878","journal-title":"Nature"},{"key":"10185_CR25","doi-asserted-by":"publisher","unstructured":"Alonso N, Albagha OME, Azfer A et al (2023) Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy. Ann Rheum Dis 985\u2013991. https:\/\/doi.org\/10.1136\/ard-2022-223618","DOI":"10.1136\/ard-2022-223618"},{"key":"10185_CR26","doi-asserted-by":"publisher","unstructured":"Seely KD, Kotelko CA, Douglas H et al (2021) The human gut microbiota: a key mediator of osteoporosis and osteogenesis. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms22179452","DOI":"10.3390\/ijms22179452"},{"key":"10185_CR27","doi-asserted-by":"publisher","unstructured":"Chen Y, Wang X, Zhang C et al (2022) Gut microbiota and bone diseases: a growing partnership. Front Microbiol 13. https:\/\/doi.org\/10.3389\/fmicb.2022.877776","DOI":"10.3389\/fmicb.2022.877776"},{"key":"10185_CR28","doi-asserted-by":"publisher","unstructured":"Ke K, Arra M, Abu-Amer Y (2019) Mechanisms underlying bone loss associated with gut inflammation. Int J Mol Sci 20.\u00a0https:\/\/doi.org\/10.3390\/ijms20246323","DOI":"10.3390\/ijms20246323"},{"key":"10185_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2022.821429","volume":"12","author":"Q Yan","year":"2022","unstructured":"Yan Q, Cai L, Guo W (2022) New advances in improving bone health based on specific gut microbiota. Front Cell Infect Microbiol 12:1\u201311. https:\/\/doi.org\/10.3389\/fcimb.2022.821429","journal-title":"Front Cell Infect Microbiol"},{"key":"10185_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115317","volume":"135","author":"J Behera","year":"2020","unstructured":"Behera J, Ison J, Tyagi SC, Tyagi N (2020) The role of gut microbiota in bone homeostasis. Bone 135:115317. https:\/\/doi.org\/10.1016\/j.bone.2020.115317","journal-title":"Bone"},{"key":"10185_CR31","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1302\/2046-3758.98.BJR-2020-0089.R1","volume":"9","author":"S Li","year":"2020","unstructured":"Li S, Mao Y, Zhou F et al (2020) Gut microbiome and osteoporosis. Bone Jt Res 9:524\u2013530. https:\/\/doi.org\/10.1302\/2046-3758.98.BJR-2020-0089.R1","journal-title":"Bone Jt Res"},{"key":"10185_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2020.620466","volume":"11","author":"OD Cooney","year":"2021","unstructured":"Cooney OD, Nagareddy PR, Murphy AJ, Lee MKS (2021) Healthy gut, healthy bones: targeting the gut microbiome to promote bone health. Front Endocrinol (Lausanne) 11:1\u20137. https:\/\/doi.org\/10.3389\/fendo.2020.620466","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10185_CR33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4161\/gmic.19320","volume":"3","author":"HJ Wu","year":"2012","unstructured":"Wu HJ, Wu E (2012) The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 3:4\u201314. https:\/\/doi.org\/10.4161\/gmic.19320","journal-title":"Gut Microbes"},{"key":"10185_CR34","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","volume":"30","author":"D Zheng","year":"2020","unstructured":"Zheng D, Liwinski T, Elinav E (2020) Interaction between microbiota and immunity in health and disease. Cell Res 30:492\u2013506. https:\/\/doi.org\/10.1038\/s41422-020-0332-7","journal-title":"Cell Res"},{"key":"10185_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu13062099","volume":"13","author":"Y Chen","year":"2021","unstructured":"Chen Y, Xu J, Chen Y (2021) Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders. Nutrients 13:1\u201321. https:\/\/doi.org\/10.3390\/nu13062099","journal-title":"Nutrients"},{"key":"10185_CR36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1302\/2046-3758.101.BJR-2020-0273.R1","volume":"10","author":"J Li","year":"2021","unstructured":"Li J, Ho WTP, Liu C et al (2021) The role of gut microbiota in bone homeostasis. Bone Jt Res 10:51\u201359. https:\/\/doi.org\/10.1302\/2046-3758.101.BJR-2020-0273.R1","journal-title":"Bone Jt Res"},{"key":"10185_CR37","doi-asserted-by":"publisher","first-page":"1237727","DOI":"10.3389\/fendo.2023.1237727","volume":"14","author":"PC Okoro","year":"2023","unstructured":"Okoro PC, Orwoll ES, Huttenhower C et al (2023) A two-cohort study on the association between the gut microbiota and bone density, microarchitecture, and strength. Front Endocrinol 14:1237727. https:\/\/doi.org\/10.3389\/fendo.2023.1237727","journal-title":"Front Endocrinol"},{"key":"10185_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00223-021-00924-2","volume":"110","author":"O Cronin","year":"2022","unstructured":"Cronin O, Lanham-New SA, Corfe BM et al (2022) Role of the microbiome in regulating bone metabolism and susceptibility to osteoporosis. Calcif Tissue Int 110:273\u2013284. https:\/\/doi.org\/10.1007\/s00223-021-00924-2","journal-title":"Calcif Tissue Int"},{"key":"10185_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI146619","volume":"131","author":"J Lorenzo","year":"2021","unstructured":"Lorenzo J (2021) From the gut to bone: connecting the gut microbiota with Th17 T lymphocytes and postmenopausal osteoporosis. J Clin Invest 131:1\u20133. https:\/\/doi.org\/10.1172\/JCI146619","journal-title":"J Clin Invest"},{"key":"10185_CR40","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.cmet.2020.08.012","volume":"32","author":"C Chevalier","year":"2020","unstructured":"Chevalier C, Kieser S, \u00c7olako\u011flu M et al (2020) Warmth prevents bone loss through the gut microbiota. Cell Metab 32:575-590.e7. https:\/\/doi.org\/10.1016\/j.cmet.2020.08.012","journal-title":"Cell Metab"},{"key":"10185_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108252","volume":"33","author":"H Wei","year":"2020","unstructured":"Wei H, Xu Y, Wang Y et al (2020) Identification of fibroblast activation protein as an osteogenic suppressor and anti-osteoporosis drug target. Cell Rep 33:108252. https:\/\/doi.org\/10.1016\/j.celrep.2020.108252","journal-title":"Cell Rep"},{"key":"10185_CR42","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5582\/irdr.2018.01055","volume":"7","author":"J Zhang","year":"2018","unstructured":"Zhang J, Lu Y, Wang Y et al (2018) The impact of the intestinal microbiome on bone health. Intractable Rare Dis Res 7:148\u2013155. https:\/\/doi.org\/10.5582\/irdr.2018.01055","journal-title":"Intractable Rare Dis Res"},{"key":"10185_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biology11101402","volume":"11","author":"N Zemanova","year":"2022","unstructured":"Zemanova N, Omelka R, Mondockova V et al (2022) Roles of gut microbiome in bone homeostasis and its relationship with bone-related diseases. Biology (Basel) 11:1\u201324. https:\/\/doi.org\/10.3390\/biology11101402","journal-title":"Biology (Basel)"},{"key":"10185_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2021.579323","volume":"11","author":"C Li","year":"2021","unstructured":"Li C, Pi G, Li F (2021) The role of intestinal flora in the regulation of bone homeostasis. Front Cell Infect Microbiol 11:1\u201316. https:\/\/doi.org\/10.3389\/fcimb.2021.579323","journal-title":"Front Cell Infect Microbiol"},{"key":"10185_CR45","doi-asserted-by":"publisher","first-page":"e154","DOI":"10.1016\/S2665-9913(19)30068-2","volume":"1","author":"PA Jansson","year":"2019","unstructured":"Jansson PA, Curiac D, Lazou Ahr\u00e9n I et al (2019) Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet Rheumatol 1:e154\u2013e162. https:\/\/doi.org\/10.1016\/S2665-9913(19)30068-2","journal-title":"Lancet Rheumatol"},{"key":"10185_CR46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bone.2017.04.009","volume":"115","author":"RM Jones","year":"2018","unstructured":"Jones RM, Mulle JG, Pacifici R (2018) Osteomicrobiology: the influence of gut microbiota on bone in health and disease. Bone 115:59\u201367. https:\/\/doi.org\/10.1016\/j.bone.2017.04.009","journal-title":"Bone"},{"key":"10185_CR47","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nri2062","volume":"7","author":"H Takayanagi","year":"2007","unstructured":"Takayanagi H (2007) Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7:292\u2013304. https:\/\/doi.org\/10.1038\/nri2062","journal-title":"Nat Rev Immunol"},{"key":"10185_CR48","doi-asserted-by":"publisher","first-page":"E7554","DOI":"10.1073\/pnas.1607235113","volume":"113","author":"J Yan","year":"2016","unstructured":"Yan J, Herzog JW, Tsang K et al (2016) Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A 113:E7554\u2013E7563. https:\/\/doi.org\/10.1073\/pnas.1607235113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10185_CR49","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.bmt.2022.11.007","volume":"1","author":"Z Chen","year":"2023","unstructured":"Chen Z, Cai Z, Zhuang P et al (2023) Living probiotic biomaterials for osteoporosis therapy. Biomed Technol 1:52\u201364. https:\/\/doi.org\/10.1016\/j.bmt.2022.11.007","journal-title":"Biomed Technol"},{"key":"10185_CR50","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1093\/ps\/85.9.1621","volume":"85","author":"R Mutu\u015f","year":"2006","unstructured":"Mutu\u015f R, Kocaba\u01e7li N, Alp M et al (2006) The effect of dietary probiotic supplementation on tibial bone characteristics and strength in broilers. Poult Sci 85:1621\u20131625. https:\/\/doi.org\/10.1093\/ps\/85.9.1621","journal-title":"Poult Sci"},{"key":"10185_CR51","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1089\/jmf.2011.0296","volume":"15","author":"FC Rodrigues","year":"2012","unstructured":"Rodrigues FC, Castro ASB, Rodrigues VC et al (2012) Yacon flour and bifidobacterium longum modulate bone health in rats. J Med Food 15:664\u2013670. https:\/\/doi.org\/10.1089\/jmf.2011.0296","journal-title":"J Med Food"},{"key":"10185_CR52","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.nutres.2012.03.006","volume":"32","author":"T Tomofuji","year":"2012","unstructured":"Tomofuji T, Ekuni D, Azuma T et al (2012) Supplementation of broccoli or Bifidobacterium longum-fermented broccoli suppresses serum lipid peroxidation and osteoclast differentiation on alveolar bone surface in rats fed a high-cholesterol diet. Nutr Res 32:301\u2013307. https:\/\/doi.org\/10.1016\/j.nutres.2012.03.006","journal-title":"Nutr Res"},{"key":"10185_CR53","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jcp.24340","volume":"228","author":"LR Mccabe","year":"2013","unstructured":"Mccabe LR, Irwin R, Schaefer L, Britton RA (2013) Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol 228:1793\u20131798. https:\/\/doi.org\/10.1002\/jcp.24340","journal-title":"J Cell Physiol"},{"key":"10185_CR54","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1051\/dst\/2009012","volume":"89","author":"MC Kruger","year":"2009","unstructured":"Kruger MC, Fear A, Chua WH et al (2009) The effect of Lactobacillus rhamnosus HN001 on mineral absorption and bone health in growing male and ovariectomised female rats. Dairy Sci Technol 89:219\u2013231. https:\/\/doi.org\/10.1051\/dst\/2009012","journal-title":"Dairy Sci Technol"},{"key":"10185_CR55","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/BOR.0000000000000681","volume":"32","author":"LJ Favazzo","year":"2020","unstructured":"Favazzo LJ, Hendesi H, Villani DA et al (2020) The gut microbiome-joint connection: Implications in osteoarthritis. Curr Opin Rheumatol 32:92\u2013101. https:\/\/doi.org\/10.1097\/BOR.0000000000000681","journal-title":"Curr Opin Rheumatol"},{"key":"10185_CR56","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1002\/art.41729","volume":"73","author":"J Wei","year":"2021","unstructured":"Wei J, Zhang C, Zhang Y et al (2021) Association between gut microbiota and symptomatic hand osteoarthritis: data from the Xiangya Osteoarthritis Study. Arthritis Rheumatol 73:1656\u20131662. https:\/\/doi.org\/10.1002\/art.41729","journal-title":"Arthritis Rheumatol"},{"key":"10185_CR57","doi-asserted-by":"publisher","first-page":"7734","DOI":"10.1021\/jf2013716","volume":"59","author":"SS Chiang","year":"2011","unstructured":"Chiang SS, Pan TM (2011) Antiosteoporotic effects of lactobacillus-fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice. J Agric Food Chem 59:7734\u20137742. https:\/\/doi.org\/10.1021\/jf2013716","journal-title":"J Agric Food Chem"},{"key":"10185_CR58","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.idairyj.2009.06.009","volume":"19","author":"JG Kim","year":"2009","unstructured":"Kim JG, Lee E, Kim SH et al (2009) Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats. Int Dairy J 19:690\u2013695. https:\/\/doi.org\/10.1016\/j.idairyj.2009.06.009","journal-title":"Int Dairy J"},{"key":"10185_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2040622319860653","volume":"10","author":"H Liu","year":"2019","unstructured":"Liu H, Gu R, Li W et al (2019) Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation. Ther Adv Chronic Dis 10:1\u201323. https:\/\/doi.org\/10.1177\/2040622319860653","journal-title":"Ther Adv Chronic Dis"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-023-10185-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-023-10185-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-023-10185-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T12:32:09Z","timestamp":1716553929000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-023-10185-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10185"],"URL":"https:\/\/doi.org\/10.1007\/s12602-023-10185-0","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]},"assertion":[{"value":"18 October 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"J. J. A. was employed by Dr. Reddy\u2019s Laboratories Limited. Dr. Reddy\u2019s Laboratories had no direct and indirect role in the design\/analysis\/writing\/publication of this review article. Other authors have no conflict of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}