{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:30:28Z","timestamp":1790771428148,"version":"4.1.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s12602-024-10221-7","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T16:02:20Z","timestamp":1707408140000},"page":"1096-1116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Diabetic Potentials of\u00a0Lactobacillus Strains by Modulating Gut Microbiota Structure and \u03b2-Cells Regeneration in the Pancreatic Islets of Alloxan-Induced Diabetic Rats"],"prefix":"10.1007","volume":"17","author":[{"given":"Manoj","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharmar","family":"Muthurayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukumaran","family":"Karthika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhalingam","family":"Gayathri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perumal","family":"Varalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramaniem","family":"Ashokkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"issue":"7","key":"10221_CR1","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.2337\/dc22-2376","volume":"46","author":"MR Rooney","year":"2023","unstructured":"Rooney MR, Fang M, Ogurtsova K, Ozkan B, Echouffo-Tcheugui JB, Boyko EJ, Magliano DJ, Selvin E (2023) Global prevalence of prediabetes. Diabetes Care 46(7):1388\u20131394. https:\/\/doi.org\/10.2337\/dc22-2376","journal-title":"Diabetes Care"},{"key":"10221_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.690379","volume":"12","author":"F Leenders","year":"2021","unstructured":"Leenders F, Groen N, de Graaf N et al (2021) Oxidative stress leads to \u03b2-cell dysfunction through loss of \u03b2-cell identity. Front Immunol 12:690379. https:\/\/doi.org\/10.3389\/fimmu.2021.690379","journal-title":"Front Immunol"},{"issue":"1","key":"10221_CR3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13098-022-00873-2","volume":"14","author":"T Jiang","year":"2022","unstructured":"Jiang T, Zhang Y, Dai F, Liu C, Hu H, Zhang Q (2022) Advanced glycation end products and diabetes and other metabolic indicators. Diabetol Metab Syndr 14(1):104. https:\/\/doi.org\/10.1186\/s13098-022-00873-2","journal-title":"Diabetol Metab Syndr"},{"issue":"1","key":"10221_CR4","doi-asserted-by":"publisher","first-page":"13264","DOI":"10.1038\/s41598-021-92630-0","volume":"11","author":"D Indyk","year":"2021","unstructured":"Indyk D, Bronowicka-Szyde\u0142ko A, Gamian A, Kuzan A (2021) Advanced glycation end products and their receptors in serum of patients with type 2 diabetes. Sci Rep 11(1):13264. https:\/\/doi.org\/10.1038\/s41598-021-92630-0","journal-title":"Sci Rep"},{"key":"10221_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1749-6632.2011.06320.x","volume":"1243","author":"R Ramasamy","year":"2011","unstructured":"Ramasamy R, Yan SF, Schmidt AM (2011) Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications. Ann NY Acad Sci 1243:88\u2013102. https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06320.x","journal-title":"Ann NY Acad Sci"},{"key":"10221_CR6","doi-asserted-by":"publisher","first-page":"1128872","DOI":"10.3389\/fphar.2023.1128872","volume":"14","author":"K Taguchi","year":"2023","unstructured":"Taguchi K, Fukami K (2023) RAGE signaling regulates the progression of diabetic complications. Front Pharmacol 14:1128872. https:\/\/doi.org\/10.3389\/fphar.2023.1128872","journal-title":"Front Pharmacol"},{"issue":"1","key":"10221_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.15420\/ecr.2018.33.1","volume":"14","author":"S Tsalamandris","year":"2019","unstructured":"Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S, Tousoulis D (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol 14(1):50\u201359. https:\/\/doi.org\/10.15420\/ecr.2018.33.1","journal-title":"Eur Cardiol"},{"issue":"17","key":"10221_CR8","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.3390\/ijms21176275","volume":"21","author":"U Galicia-Garcia","year":"2020","unstructured":"Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Mart\u00edn C (2020) Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci 21(17):6275. https:\/\/doi.org\/10.3390\/ijms21176275","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10221_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s43162-021-00081-w","volume":"33","author":"A Chakraborty","year":"2021","unstructured":"Chakraborty A, Sami SA, Marma KKS (2021) A comprehensive review on RAGE-facilitated pathological pathways connecting Alzheimer\u2019s disease, diabetes mellitus, and cardiovascular diseases. Egypt J Intern Med 33(1):47. https:\/\/doi.org\/10.1186\/s43162-021-00081-w","journal-title":"Egypt J Intern Med"},{"key":"10221_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/mnfr.201700118","volume":"61","author":"W Qu","year":"2017","unstructured":"Qu W, Yuan X, Zhao J, Zhang Y, Hu J, Wang J, Li J (2017) Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats. Mol Nutr Food Res 61:1\u201314","journal-title":"Mol Nutr Food Res"},{"issue":"6","key":"10221_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09725","volume":"8","author":"BA Tegegne","year":"2022","unstructured":"Tegegne BA, Kebede B (2022) Probiotics, their prophylactic and therapeutic applications in human health development: a review of the literature. Heliyon 8(6):e09725. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09725","journal-title":"Heliyon"},{"issue":"7","key":"10221_CR12","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.1039\/c9fo02761k","volume":"11","author":"G Wang","year":"2020","unstructured":"Wang G, Si Q, Yang S, Jiao T, Zhu H, Tian P, Chen W (2020) Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners. Food Funct 11(7):5898\u20135914. https:\/\/doi.org\/10.1039\/c9fo02761k","journal-title":"Food Funct"},{"issue":"15","key":"10221_CR13","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.3390\/nu14153001","volume":"14","author":"M Samtiya","year":"2022","unstructured":"Samtiya M, Samtiya S, Badgujar PC, Puniya AK, Dhewa T, Aluko RE (2022) Health-promoting and therapeutic attributes of milk-derived bioactive peptides. Nutrients 14(15):3001. https:\/\/doi.org\/10.3390\/nu14153001","journal-title":"Nutrients"},{"key":"10221_CR14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3390\/nu15020277","volume":"15","author":"S-W Lin","year":"2023","unstructured":"Lin S-W, Wu C-H, Jao Y-C, Tsai Y-S, Chen Y-L, Chen C-C, Fang TJ, Chau C-F (2023) Fermented supernatants of Lactobacillus plantarum GKM3 and Bifidobacterium lactis GKK2 protect against protein glycation and inhibit glycated protein ligation. Nutrients 15:277. https:\/\/doi.org\/10.3390\/nu15020277","journal-title":"Nutrients"},{"key":"10221_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/5110276","volume":"2021","author":"L Zhang","year":"2021","unstructured":"Zhang L, Chu J, Hao W et al (2021) Gut Microbiota and type 2 diabetes mellitus: association, mechanism, and translational applications. Mediators Inflamm 2021:1\u201312. https:\/\/doi.org\/10.1155\/2021\/5110276","journal-title":"Mediators Inflamm"},{"issue":"6","key":"10221_CR16","doi-asserted-by":"publisher","first-page":"688","DOI":"10.4161\/19490976.2014.983763","volume":"5","author":"A Mathias","year":"2014","unstructured":"Mathias A, Pais B, Favre L, Benyacoub J, Corth\u00e9sy B (2014) Role of secretory IgA in the mucosal sensing of commensal bacteria. Gut Microbes 5(6):688\u2013695. https:\/\/doi.org\/10.4161\/19490976.2014.983763","journal-title":"Gut Microbes"},{"key":"10221_CR17","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.3389\/fmicb.2018.01835","volume":"9","author":"ZY Kho","year":"2018","unstructured":"Kho ZY, Lal SK (2018) The human gut microbiome - a potential controller of wellness and disease. Front Microbiol 9:1835. https:\/\/doi.org\/10.3389\/fmicb.2018.01835","journal-title":"Front Microbiol"},{"issue":"6","key":"10221_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251646","volume":"16","author":"PS Hsieh","year":"2021","unstructured":"Hsieh PS, Ho HH, Tsao SP, Hsieh SH, Lin WY, Chen JF, Huang HY (2021) Multi-strain probiotic supplement attenuates streptozotocin-induced type-2 diabetes by reducing inflammation and \u03b2-cell death in rats. PLoS ONE 16(6):e0251646. https:\/\/doi.org\/10.1371\/journal.pone.0251646","journal-title":"PLoS ONE"},{"issue":"3","key":"10221_CR19","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1080\/08905436.2022.2092494","volume":"36","author":"M Kumar","year":"2022","unstructured":"Kumar M, Karthika S, Anjitha N, Varalakshmi P, Ashokkumar B (2022) Screening for probiotic attributes of lactic acid bacteria isolated from human milk and evaluation of their anti-diabetic potentials. Food Biotechnol 36(3):234\u2013265. https:\/\/doi.org\/10.1080\/08905436.2022.2092494","journal-title":"Food Biotechnol"},{"key":"10221_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.clinbiochem.2006.10.004","volume":"40","author":"MS Even","year":"2007","unstructured":"Even MS, Sandusky CB, Barnard ND, Mistry J, Sinha K (2007) Development of a novel ELISA for human insulin using monoclonal antibodies produced in serum-free cell culture medium. Clin Biochem 40:98\u2013103","journal-title":"Clin Biochem"},{"issue":"7","key":"10221_CR21","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1369\/0022155416649579","volume":"64","author":"C Perry","year":"2016","unstructured":"Perry C, Chung JY, Ylaya K et al (2016) A buffered alcohol-based fixative for histomorphologic and molecular applications. J Histochem Cytochem 64(7):425\u2013440. https:\/\/doi.org\/10.1369\/0022155416649579","journal-title":"J Histochem Cytochem"},{"issue":"2","key":"10221_CR22","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","volume":"51","author":"S Lenzen","year":"2008","unstructured":"Lenzen S (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51(2):216\u2013226. https:\/\/doi.org\/10.1007\/s00125-007-0886-7","journal-title":"Diabetologia"},{"issue":"3","key":"10221_CR23","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","volume":"166","author":"AJ King","year":"2012","unstructured":"King AJ (2012) The use of animal models in diabetes research. Br J Pharmacol 166(3):877\u2013894. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.01911.x","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10221_CR24","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1089\/jmf.2007.0544","volume":"12","author":"IP Kaur","year":"2009","unstructured":"Kaur IP, Kuhad A, Garg A, Chopra K (2009) Probiotics: delineation of prophylactic and therapeutic benefits. J Med Food 12(2):219\u2013235","journal-title":"J Med Food"},{"key":"10221_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109914","volume":"125","author":"Y Wang","year":"2020","unstructured":"Wang Y, Dilidaxi D, Wu Y, Sailike J, Sun X, Nabi X-H (2020) Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db\/db mice. Biomed Pharmacother 125:109914. https:\/\/doi.org\/10.1016\/j.biopha.2020.109914","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10221_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284303","volume":"18","author":"J Nopparat","year":"2023","unstructured":"Nopparat J, Khuituan P, Peerakietkhajorn S, Teanpaisan R (2023) Probiotics of Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 attenuate inflammation and \u03b2-cell death in streptozotocin-induced type 1 diabetic mice. PLoS ONE 18(4):e0284303. https:\/\/doi.org\/10.1371\/journal.pone.0284303","journal-title":"PLoS ONE"},{"issue":"6","key":"10221_CR27","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","volume":"54","author":"M Brownlee","year":"2005","unstructured":"Brownlee M (2005) The pathobiology of diabetic complications. Diabetes 54(6):1615\u20131625. https:\/\/doi.org\/10.2337\/diabetes.54.6.1615","journal-title":"Diabetes"},{"key":"10221_CR28","doi-asserted-by":"publisher","unstructured":"Nakagawa P, Gomez J, Grobe JL, Sigmund CD (2020) The renin-angiotensin system in the central nervous system and its role in blood pressure regulation. Curr Hypertens Rep 22(1). https:\/\/doi.org\/10.1007\/s11906-019-1011-2","DOI":"10.1007\/s11906-019-1011-2"},{"issue":"2","key":"10221_CR29","doi-asserted-by":"publisher","first-page":"M75","DOI":"10.1111\/j.1750-3841.2007.00643.x","volume":"73","author":"L Ramchandran","year":"2008","unstructured":"Ramchandran L, Shah NP (2008) Proteolytic profiles and angiotensin-I converting enzyme and \u03b1-glucosidase inhibitory activities of selected lactic acid bacteria. J Food Sci 73(2):M75\u2013M81. https:\/\/doi.org\/10.1111\/j.1750-3841.2007.00643.x","journal-title":"J Food Sci"},{"key":"10221_CR30","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/bcp.13002","volume":"83","author":"S Marcone","year":"2017","unstructured":"Marcone S, Belton O, Fitzgerald DJ (2017) Milk derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis. Br J Clin Pharmacol 83:152\u2013162. https:\/\/doi.org\/10.1111\/bcp.13002","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"10221_CR31","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.3168\/jds.2015-9382","volume":"98","author":"Y Chen","year":"2015","unstructured":"Chen Y, Li C, Xue J, Kwok LY, Yang J, Zhang H, Menghe B (2015) Characterization of angiotensin-converting enzyme inhibitory activity of fermented milk produced by Lactobacillus helveticus. J Dairy Sci 98(8):5113\u20135124. https:\/\/doi.org\/10.3168\/jds.2015-9382","journal-title":"J Dairy Sci"},{"key":"10221_CR32","doi-asserted-by":"publisher","unstructured":"Yang G,\u00a0Jiang Y, Yang W,\u00a0Du F,\u00a0Yao Y,\u00a0Shi C,\u00a0Wang C (2015) Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide. Microb Cell Fact 14(1). https:\/\/doi.org\/10.1186\/s12934-015-0394-2","DOI":"10.1186\/s12934-015-0394-2"},{"issue":"15","key":"10221_CR33","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.3390\/foods11152332","volume":"11","author":"L Yuan","year":"2022","unstructured":"Yuan L, Li Y, Chen M, Xue L, Wang J, Ding Y, Wu Q (2022) Antihypertensive activity of milk fermented by Lactiplantibacillus plantarum SR37-3 and SR61-2 in L-NAME-induced hypertensive rats. Foods (Basel, Switzerland) 11(15):2332. https:\/\/doi.org\/10.3390\/foods11152332","journal-title":"Foods (Basel, Switzerland)"},{"issue":"10","key":"10221_CR34","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.2337\/diabetes.54.10.2939","volume":"54","author":"P Plomgaard","year":"2005","unstructured":"Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK (2005) Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes 54(10):2939\u20132945. https:\/\/doi.org\/10.2337\/diabetes.54.10.2939","journal-title":"Diabetes"},{"key":"10221_CR35","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2337\/diab.44.1.112","volume":"44","author":"C Mueller","year":"1995","unstructured":"Mueller C, Held W, Imobden MA, Carnaud C (1995) Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-\u03b1 and granzyme A in the intra-islet infiltrates. Diabetes 44:112\u2013117","journal-title":"Diabetes"},{"key":"10221_CR36","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.4014\/jmb.1601.01044","volume":"26","author":"YD Lee","year":"2016","unstructured":"Lee YD, Hong YF, Jeon B, Jung BJ, Chung DK, Kim H (2016) Differential cytokine regulatory effect of three lactobacillus strains isolated from fermented foods. J Microbiol Biotechnol 26:1517\u20131526","journal-title":"J Microbiol Biotechnol"},{"issue":"1","key":"10221_CR37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1743-7075-10-35","volume":"10","author":"FC Hsieh","year":"2013","unstructured":"Hsieh FC, Lee CL, Chai CY, Chen WT, Lu YC, Wu CS (2013) Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats. Nutr Metab (Lond) 10(1):35. https:\/\/doi.org\/10.1186\/1743-7075-10-35","journal-title":"Nutr Metab (Lond)"},{"issue":"8","key":"10221_CR38","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00615-20","volume":"89","author":"HS Youn","year":"2021","unstructured":"Youn HS, Kim J-H, Lee JS, Yoon YY, Choi SJ, Lee JY, Hwang KW (2021) Lactobacillus plantarum reduces low-grade inflammation and glucose levels in a mouse model of chronic stress and diabetes. Infect Immun 89(8):e0061520. https:\/\/doi.org\/10.1128\/IAI.00615-20","journal-title":"Infect Immun"},{"key":"10221_CR39","doi-asserted-by":"publisher","first-page":"754401","DOI":"10.3389\/fendo.2022.754401","volume":"13","author":"CH Wang","year":"2022","unstructured":"Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, Kuo YW, Huang YY, Tsai SY, Lin HC (2022) Adjuvant probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 attenuate glycemic levels and inflammatory cytokines in patients with type 1\u00a0diabetes\u00a0mellitus. Front Endocrinol 13:754401. https:\/\/doi.org\/10.3389\/fendo.2022.754401","journal-title":"Front Endocrinol"},{"issue":"6","key":"10221_CR40","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/mi.2011.41","volume":"4","author":"NJ Mantis","year":"2011","unstructured":"Mantis NJ, Rol N, Corth\u00e9sy B (2011) Secretory IgA\u2019s complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol 4(6):603\u2013611. https:\/\/doi.org\/10.1038\/mi.2011.41","journal-title":"Mucosal Immunol"},{"issue":"1\u20132","key":"10221_CR41","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/s0168-1605(98)00056-7","volume":"42","author":"Y Fukushima","year":"1998","unstructured":"Fukushima Y, Kawata Y, Hara H, Terada A, Mitsuoka T (1998) Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol 42(1\u20132):39\u201344. https:\/\/doi.org\/10.1016\/s0168-1605(98)00056-7","journal-title":"Int J Food Microbiol"},{"issue":"2","key":"10221_CR42","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1248\/bpb.33.289","volume":"33","author":"H Jin","year":"2010","unstructured":"Jin H, Higashikaw F, Noda M, Zhao X, Matoba Y, Kumagai T, Sugiyama M (2010) Establishment of an in vitro Peyer\u2019s patch cell culture system correlative to in vivo study using intestine and screening of lactic acid bacteria enhancing intestinal immunity. Biol Pharm Bull 33(2):289\u2013293. https:\/\/doi.org\/10.1248\/bpb.33.289","journal-title":"Biol Pharm Bull"},{"key":"10221_CR43","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.3390\/foods10071455","volume":"10","author":"P Toejing","year":"2021","unstructured":"Toejing P, Khampithum N, Sirilun S, Chaiyasut C, Lailerd N (2021) Influence of Lactobacillus paracasei HII01 supplementation on glycemia and inflammatory biomarkers in type 2 diabetes: a randomized clinical trial. Foods 10:1455. https:\/\/doi.org\/10.3390\/foods10071455","journal-title":"Foods"},{"issue":"1","key":"10221_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086416","volume":"9","author":"Y Kikuchi","year":"2014","unstructured":"Kikuchi Y, Kunitoh-Asari A, Hayakawa K et al (2014) Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice. PLoS ONE 9(1):e86416. https:\/\/doi.org\/10.1371\/journal.pone.0086416","journal-title":"PLoS ONE"},{"key":"10221_CR45","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/jn\/134.1.153","volume":"134","author":"M Roller","year":"2004","unstructured":"Roller M, Rechkemmer G, Watzl B (2004) Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune functions in rats. J Nutr 134:153\u2013156","journal-title":"J Nutr"},{"key":"10221_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2021.100093","volume":"10","author":"A Pegah","year":"2021","unstructured":"Pegah A, Abbasi-Oshaghi E, Khodadadi I, Mirzaei F, Tayebinia H (2021) Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats. Metabolism Open 10:100093. https:\/\/doi.org\/10.1016\/j.metop.2021.100093","journal-title":"Metabolism Open"},{"issue":"104367","key":"10221_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104367","volume":"147","author":"P Dey","year":"2019","unstructured":"Dey P (2019) Gut microbiota in phytopharmacology: a comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions. Pharmacol Res 147(104367):104367. https:\/\/doi.org\/10.1016\/j.phrs.2019.104367","journal-title":"Pharmacol Res"},{"key":"10221_CR48","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrmicro3552","volume":"14","author":"GP Donaldson","year":"2016","unstructured":"Donaldson GP, Lee SM, Mazmanian SK (2016) Gut biogeography of the bacterial microbiota. Nat Rev Microbiol 14:20\u201332","journal-title":"Nat Rev Microbiol"},{"issue":"8","key":"10221_CR49","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.2174\/1871527313666141023153506","volume":"13","author":"I Khan","year":"2014","unstructured":"Khan I, Yasir M, Azhar E, Kumosani T, Barbour KE, Bibi F, Kamal AM (2014) Implication of gut Microbiota in human health. CNS Neurol Disord Drug Targets 13(8):1325\u20131333. https:\/\/doi.org\/10.2174\/1871527313666141023153506","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10221_CR50","doi-asserted-by":"publisher","unstructured":"Chen X, Devaraj S (2018) Gut microbiome in obesity, metabolic syndrome, and diabetes. Curr Diab Rep 18(12). https:\/\/doi.org\/10.1007\/s11892-018-1104-3","DOI":"10.1007\/s11892-018-1104-3"},{"issue":"6","key":"10221_CR51","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00125-","volume":"60","author":"L Brunkwall","year":"2017","unstructured":"Brunkwall L, Orho-Melander M (2017) The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities. Diabetologia 60(6):943\u2013951. https:\/\/doi.org\/10.1007\/s00125-","journal-title":"Diabetologia"},{"key":"10221_CR52","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.phrs.2017.11.008","volume":"129","author":"SZ Vahed","year":"2018","unstructured":"Vahed SZ, Barzegari A, Zuluaga M, Letourneur D, Pavon-Djavid G (2018) Myocardial infarction and gut microbiota: an incidental connection. Pharmacol Res 129:308\u2013317. https:\/\/doi.org\/10.1016\/j.phrs.2017.11.008","journal-title":"Pharmacol Res"},{"key":"10221_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0183-1","author":"M He","year":"2017","unstructured":"He M, Shi B (2017) Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell Biosci. https:\/\/doi.org\/10.1186\/s13578-017-0183-1","journal-title":"Cell Biosci"},{"key":"10221_CR54","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.26355\/eurrev_202002_20213","volume":"24","author":"D Pitocco","year":"2020","unstructured":"Pitocco D, Di Leo M, Tartaglione L, De Leva F, Petruzziello C, Saviano A, Pontecorvi A, Ojetti V (2020) The role of gut microbiota in mediating obesity and diabetes mellitus. Eur Rev Med Pharmacol Sci 24:1548\u20131562. https:\/\/doi.org\/10.26355\/eurrev_202002_20213","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"6","key":"10221_CR55","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1128\/AEM.66.6.2578-2588.2000","volume":"66","author":"GW Tannock","year":"2000","unstructured":"Tannock GW, Munro K, Harmsen HJ, Welling GW, Smart J, Gopal PK (2000) Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl Environ Microbiol 66(6):2578\u20132588","journal-title":"Appl Environ Microbiol"},{"issue":"4","key":"10221_CR56","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3390\/biology10040348","volume":"10","author":"A Gulnaz","year":"2021","unstructured":"Gulnaz A, Nadeem J, Han J-H, Lew L-C, Son J-D, Park Y-H, Hor Y-Y (2021) Lactobacillus sps in reducing the risk of diabetes in high-fat diet-induced diabetic mice by modulating the gut microbiome and inhibiting key digestive enzymes associated with diabetes. Biology 10(4):348. https:\/\/doi.org\/10.3390\/biology10040348","journal-title":"Biology"},{"issue":"10","key":"10221_CR57","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.3390\/nu11102530","volume":"11","author":"M Cabello-Olmo","year":"2019","unstructured":"Cabello-Olmo M, Oneca M, Torre P, Sainz N, Moreno-Aliaga MJ, Guruceaga E, Arana M (2019) A fermented food product containing lactic acid bacteria protects ZDF rats from the development of type 2 diabetes. Nutrients 11(10):2530. https:\/\/doi.org\/10.3390\/nu11102530","journal-title":"Nutrients"},{"issue":"7285","key":"10221_CR58","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"J Qin","year":"2010","unstructured":"Qin J, Li R, Raes J et al (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464(7285):59\u201365. https:\/\/doi.org\/10.1038\/nature08821","journal-title":"Nature"},{"key":"10221_CR59","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","volume":"473","author":"M Arumugam","year":"2011","unstructured":"Arumugam M, Raes J, Pelletier E et al (2011) Enterotypes of the human gut microbiome. Nature 473:174\u2013180. https:\/\/doi.org\/10.1038\/nature09944","journal-title":"Nature"},{"key":"10221_CR60","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.2147\/jir.s358807","volume":"15","author":"W Gu","year":"2022","unstructured":"Gu W, Zhang L, Han T, Huang H, Chen J (2022) Dynamic changes in gut microbiome of ulcerative colitis: initial study from animal model. J Inflamm Res 15:2631\u20132647. https:\/\/doi.org\/10.2147\/jir.s358807","journal-title":"J Inflamm Res"},{"issue":"1","key":"10221_CR61","doi-asserted-by":"publisher","first-page":"65","DOI":"10.12938\/bmfh.2019-031","volume":"40","author":"KS Ibrahim","year":"2021","unstructured":"Ibrahim KS, Bourwis N, Dolan S, Lang S, Spencer J, Craft JA (2021) Characterisation of gut microbiota of obesity and type 2 diabetes in a rodent model. Biosci Microbiota Food Health 40(1):65\u201374. https:\/\/doi.org\/10.12938\/bmfh.2019-031","journal-title":"Biosci Microbiota Food Health"},{"issue":"18","key":"10221_CR62","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.3390\/nu14183707","volume":"14","author":"X Hu","year":"2022","unstructured":"Hu X, He X, Peng C, He Y, Wang C, Tang W, He L (2022) Improvement of ulcerative colitis by aspartate via RIPK pathway modulation and gut microbiota composition in mice. Nutrients 14(18):3707. https:\/\/doi.org\/10.3390\/nu14183707","journal-title":"Nutrients"},{"issue":"109873","key":"10221_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109873","volume":"124","author":"Q Ma","year":"2020","unstructured":"Ma Q, Li Y, Wang J, Li P, Duan Y, Dai H, Zhao B (2020) Investigation of gut microbiome changes in type 1 diabetic mellitus rats based on high-throughput sequencing. Biomed Pharmacother [Biomed Pharmacother] 124(109873):109873. https:\/\/doi.org\/10.1016\/j.biopha.2020.109873","journal-title":"Biomed Pharmacother [Biomed Pharmacother]"},{"issue":"1","key":"10221_CR64","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1099\/mic.0.082610-0","volume":"161","author":"E Patterson","year":"2015","unstructured":"Patterson E, Marques TM, Sullivan O, Fitzgerald P, Fitzgerald GF, Cotter PD, Ross RP (2015) Streptozotocin-induced type-1-diabetes disease onset in Sprague-Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity. Microbiology (Reading, England) 161(1):182\u2013193. https:\/\/doi.org\/10.1099\/mic.0.082610-0","journal-title":"Microbiology (Reading, England)"},{"issue":"7122","key":"10221_CR65","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/4441022a","volume":"444","author":"RE Ley","year":"2006","unstructured":"Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Human gut microbes associated with obesity. Nature 444(7122):1022\u20131023. https:\/\/doi.org\/10.1038\/4441022a","journal-title":"Nature"},{"issue":"10","key":"10221_CR66","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1038\/ismej.2014.45","volume":"8","author":"A Everard","year":"2014","unstructured":"Everard A, Lazarevic V, Ga\u00efa N, Johansson M, St\u00e5hlman M, Backhed F, Cani PD (2014) Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J 8(10):2116\u20132130. https:\/\/doi.org\/10.1038\/ismej.2014.45","journal-title":"ISME J"},{"issue":"1","key":"10221_CR67","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/oby.2009.167","volume":"18","author":"A Schwiertz","year":"2010","unstructured":"Schwiertz A, Taras D, Sch\u00e4fer K, Beijer S, Bos NA, Donus C, Hardt PD (2010) Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring, Md.) 18(1):190\u2013195. https:\/\/doi.org\/10.1038\/oby.2009.167","journal-title":"Obesity (Silver Spring, Md.)"},{"issue":"2","key":"10221_CR68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009085","volume":"5","author":"N Larsen","year":"2010","unstructured":"Larsen N, Vogensen FK, van den Berg FWJ, Nielsen DS, Andreasen AS, Pedersen BK, Jakobsen M (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS ONE 5(2):e9085. https:\/\/doi.org\/10.1371\/journal.pone.0009085","journal-title":"PLoS ONE"},{"key":"10221_CR69","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"PD Cani","year":"2007","unstructured":"Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delm\u00e9e E, Cousin B, Sulpice T, Chamontin B, Ferri\u00e8res J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56:1761\u20131772","journal-title":"Diabetes"},{"issue":"15","key":"10221_CR70","doi-asserted-by":"publisher","first-page":"6809","DOI":"10.1039\/d1fo00515d","volume":"12","author":"Z Zeng","year":"2021","unstructured":"Zeng Z, Guo X, Zhang J, Yuan Q, Chen S (2021) Lactobacillus paracasei modulates the gut microbiota and improves inflammation in type 2 diabetic rats. Food Funct 12(15):6809\u20136820. https:\/\/doi.org\/10.1039\/d1fo00515d","journal-title":"Food Funct"},{"key":"10221_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.718564","author":"E Fabersani","year":"2021","unstructured":"Fabersani E, Marquez A, Russo M, Ross R, Torres S, Fontana C, Gauffin-Cano P (2021) Lactic acid bacteria strains differently modulate gut microbiota and metabolic and immunological parameters in high-fat diet-fed mice. Front Nutr. https:\/\/doi.org\/10.3389\/fnut.2021.718564","journal-title":"Front Nutr"},{"key":"10221_CR72","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5281639","author":"Y Yue","year":"2020","unstructured":"Yue Y, Xu X, Yang B, Lu J, Zhang S, Liu L, Nassar K, Zhang C, Zhang M, Pang X, Lv J (2020) Stable colonization of orally administered Lactobacillus casei SY13 alters the gut microbiota. BioMed Res Int. https:\/\/doi.org\/10.1155\/2020\/5281639","journal-title":"BioMed Res Int"},{"key":"10221_CR73","doi-asserted-by":"publisher","first-page":"S130","DOI":"10.1080\/10408398.2018.1542587","volume":"59","author":"X Fu","year":"2019","unstructured":"Fu X, Liu Z, Zhu C, Mou H, Kong Q (2019) Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria. Crit Rev Food Sci Nutr 59:S130\u2013S152","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10221_CR74","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00554","author":"T-L Lin","year":"2020","unstructured":"Lin T-L, Shu C-C, Chen Y-M, Lu J-J, Wu T-S, Lai W-F, Lu C-C (2020) Like cures like: pharmacological activity of anti-inflammatory lipopolysaccharides from gut microbiome. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2020.00554","journal-title":"Front Pharmacol"},{"key":"10221_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.11.051","volume":"51","author":"M Gurung","year":"2020","unstructured":"Gurung M, Li Z, You H et al (2020) Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine 51:102590. https:\/\/doi.org\/10.1016\/j.ebiom.2019.11.051","journal-title":"EBioMedicine"},{"issue":"7","key":"10221_CR76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041079","volume":"7","author":"PG Cano","year":"2012","unstructured":"Cano PG, Santacruz A, Moya A, Sanz Y (2012) Bacteroides uniformis CECT 7771 ameliorates metabolic and immunological dysfunction in mice with high-fat-diet induced obesity. PLoS ONE 7(7):e41079. https:\/\/doi.org\/10.1371\/journal.pone.0041079","journal-title":"PLoS ONE"},{"key":"10221_CR77","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nature07008","volume":"453","author":"SK Mazmanian","year":"2008","unstructured":"Mazmanian SK, Round JL, Kasper DL (2008) A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453:620\u2013625","journal-title":"Nature"},{"key":"10221_CR78","doi-asserted-by":"publisher","first-page":"206","DOI":"10.4172\/2168-9652.1000206","volume":"5","author":"C Chen","year":"2016","unstructured":"Chen C, Shao Y, Wu X, Huang C, Lu W (2016) Elevated interleukin-17 levels in patients with newly diagnosed type 2 diabetes mellitus. Biochem Physiol 5:206. https:\/\/doi.org\/10.4172\/2168-9652.1000206","journal-title":"Biochem Physiol"},{"key":"10221_CR79","doi-asserted-by":"publisher","unstructured":"Girdhar K, Huang Q, Chow I-T, Vatanen T, Brady C, Raisingani A, Altindis E (2022) A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes. Proc Natl Acad Sci USA 119(31). https:\/\/doi.org\/10.1073\/pnas.2120028119","DOI":"10.1073\/pnas.2120028119"},{"issue":"1","key":"10221_CR80","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/QCO.0000000000000028","volume":"27","author":"C Schneeberger","year":"2014","unstructured":"Schneeberger C, Kazemier BM, Geerlings SE (2014) Asymptomatic bacteriuria and urinary tract infections in special patient groups: women with diabetes mellitus and pregnant women. Curr Opin Infect Dis 27(1):108\u2013114. https:\/\/doi.org\/10.1097\/QCO.0000000000000028","journal-title":"Curr Opin Infect Dis"},{"key":"10221_CR81","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1741-7015-11-46","volume":"11","author":"M Murri","year":"2013","unstructured":"Murri M, Leiva I, Gomez-Zumaquero JM, Tinahones FJ, Cardona F, Soriguer F, Queipo-Ortu\u00f1o MI (2013) Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study. BMC Med 11:46. https:\/\/doi.org\/10.1186\/1741-7015-11-46","journal-title":"BMC Med"},{"key":"10221_CR82","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1042\/BJ20082222","volume":"420","author":"N Burger-van Paassen","year":"2009","unstructured":"Burger-van Paassen N, Vincent A, Puiman PJ, van der Sluis M, Bouma J, Boehm G, van Goudoever JB, van Seuningen I, Renes IB (2009) The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection. Biochem J 420:211\u2013219","journal-title":"Biochem J"},{"key":"10221_CR83","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.jdiacomp.2016.01.005","volume":"30","author":"A Malmartel","year":"2016","unstructured":"Malmartel A, Ghasarossian C (2016) Bacterial resistance in urinary tract infections in patients with diabetes matched with patients without diabetes. J Diabetes Complicat 30:705\u2013709. https:\/\/doi.org\/10.1016\/j.jdiacomp.2016.01.005","journal-title":"J Diabetes Complicat"},{"key":"10221_CR84","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3168\/jds.2016-11870","volume":"100","author":"F Zhang","year":"2017","unstructured":"Zhang F, Qiu L, Xu X, Liu Z, Zhan H, Tao X, Shah NP, Wei H (2017) Beneficial effects of probiotic cholesterol-lowering strain of Enterococcus faecium WEFA23 from infants on diet-induced metabolic syndrome in rats. J Dairy Sci 100:1618\u20131628","journal-title":"J Dairy Sci"},{"issue":"4","key":"10221_CR85","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.3168\/jds.2019-17185","volume":"103","author":"M Wei","year":"2020","unstructured":"Wei M, Gu E, Luo J, Zhang Z, Xu D, Tao X, Wei H (2020) Enterococcus hirae WEHI01 isolated from a healthy Chinese infant ameliorates the symptoms of type 2 diabetes by elevating the abundance of Lactobacillales in rats. J Dairy Sci 103(4):2969\u20132981. https:\/\/doi.org\/10.3168\/jds.2019-17185","journal-title":"J Dairy Sci"},{"key":"10221_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.133974","volume":"399","author":"D Peng","year":"2023","unstructured":"Peng D, Tian WN, An MQ, Chen YL, Zeng WS, Zhu SY, Li P, Du B (2023) Characterization of antidiabetic effects of Dendrobium officinale derivatives in a mouse model of type 2 diabetes mellitus. Food Chem 399:133974","journal-title":"Food Chem"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10221-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10221-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10221-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T06:40:44Z","timestamp":1746513644000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10221-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,8]]},"references-count":86,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10221"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10221-7","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,8]]},"assertion":[{"value":"17 January 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}