{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:56:40Z","timestamp":1793890600545,"version":"4.8.0"},"reference-count":139,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s12602-024-10223-5","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T08:02:37Z","timestamp":1709193757000},"page":"1553-1565","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Gut Microbiota and Polycystic Ovary Syndrome (PCOS): Understanding the Pathogenesis and the Role of Probiotics as a Therapeutic Strategy"],"prefix":"10.1007","volume":"16","author":[{"given":"Samaneh","family":"Salehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Allahverdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Pourjafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khashayar","family":"Sarabandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seid Mahdi","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"issue":"9588","key":"10223_CR1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","volume":"370","author":"RJ Norman","year":"2007","unstructured":"Norman RJ, Dewailly D, Legro RS, Hickey TE (2007) Polycystic ovary syndrome. Lancet 370(9588):685\u2013697. https:\/\/doi.org\/10.1016\/S0140-6736(07)61345-2. PMID: 17720020","journal-title":"Lancet"},{"key":"10223_CR2","first-page":"1","volume":"66","author":"W Ratajczak","year":"2019","unstructured":"Ratajczak W, Ry\u0142 A, Mizerski A et al (2019) Immunomodulatory potential of gut microbiome-derived shortchain fatty acids (SCFAs). Acta Biochim Pol 66:1\u201312","journal-title":"Acta Biochim Pol"},{"key":"10223_CR3","first-page":"1","volume":"2014","author":"GILLILAND SML and RG,","year":"2001","unstructured":"GILLILAND SML and RG, (2001) Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria 2014:1\u201334","journal-title":"Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria"},{"key":"10223_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076213","author":"V Unfer","year":"2023","unstructured":"Unfer V, Dinicola S, Russo M (2023) A PCOS paradox: does inositol therapy find a rationale in all the different phenotypes? Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24076213","journal-title":"Int J Mol Sci"},{"key":"10223_CR5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1080\/07315724.2019.1657515","volume":"39","author":"G Yurtda\u015f","year":"2020","unstructured":"Yurtda\u015f G, Akdevelio\u011flu Y (2020) A new approach to polycystic ovary syndrome: the gut microbiota. J Am Coll Nutr 39:371\u2013382","journal-title":"J Am Coll Nutr"},{"issue":"1","key":"10223_CR6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","volume":"97","author":"BC Fauser","year":"2012","unstructured":"Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina E, Chang J, Yildiz BO, Laven JS, Boivin J, Petraglia F, Wijeyeratne CN, Norman RJ, Dunaif A, Franks S, Wild RA, Dumesic D, Barnhart K (2012) Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 97(1):28\u201338.e25. https:\/\/doi.org\/10.1016\/j.fertnstert.2011.09.024. Epub 2011 Dec 6. PMID: 22153789","journal-title":"Fertil Steril"},{"key":"10223_CR7","doi-asserted-by":"publisher","first-page":"201.e1","DOI":"10.1016\/j.ajog.2010.03.008","volume":"203","author":"E Carmina","year":"2010","unstructured":"Carmina E, Oberfield SE, Lobo RA (2010) The diagnosis of polycystic ovary syndrome in adolescents. Am J Obstet Gynecol 203:201.e1\u2013201.e5. https:\/\/doi.org\/10.1016\/j.ajog.2010.03.008","journal-title":"Am J Obstet Gynecol"},{"key":"10223_CR8","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.cca.2020.07.032","volume":"510","author":"M Bhati","year":"2020","unstructured":"Bhati M, D. Prabhu Y, Renu K, et al (2020) Role of TGF-\u03b2 signalling in PCOS associated focal segmental glomerulosclerosis. Clin Chim Acta 510:244\u2013251","journal-title":"Clin Chim Acta"},{"key":"10223_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/tog.12345","volume":"19","author":"AH Balen","year":"2017","unstructured":"Balen AH, Conway GS, Kaltsas G, Techatrasak K, Manning PJ, West C, Jacobs HS (1995) Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod 10(8):2107\u20132111. https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a136243. PMID: 8567849","journal-title":"Obstet Gynaecol"},{"key":"10223_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2147\/TACG.S200341","volume":"12","author":"MJ Khan","year":"2019","unstructured":"Khan MJ, Ullah A, Basit S (2019) Genetic basis of polycystic ovary syndrome (PCOS): current perspectives. Appl Clin Genet 12:249\u2013260","journal-title":"Appl Clin Genet"},{"key":"10223_CR11","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/humupd\/dmy007","volume":"24","author":"NS Kakoly","year":"2018","unstructured":"Kakoly NS, Khomami MB, Joham AE et al (2018) Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression. Hum Reprod Update 24:455\u2013467. https:\/\/doi.org\/10.1093\/humupd\/dmy007","journal-title":"Hum Reprod Update"},{"key":"10223_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01899-9","author":"MH Dahan","year":"2019","unstructured":"Dahan MH, Reaven G (2019) Relationship among obesity, insulin resistance, and hyperinsulinemia in the polycystic ovary syndrome. Endocrine. https:\/\/doi.org\/10.1007\/s12020-019-01899-9","journal-title":"Endocrine"},{"issue":"7","key":"10223_CR13","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.3390\/ijms22073789","volume":"22","author":"E Rudnicka","year":"2021","unstructured":"Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska AM, Smolarczyk R, Meczekalski B (2021) Chronic low grade inflammation in pathogenesis of PCOS. Int J Mol Sci 22(7):3789. https:\/\/doi.org\/10.3390\/ijms22073789. PMID: 33917519; PMCID: PMC8038770","journal-title":"Int J Mol Sci"},{"key":"10223_CR14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.33545\/26164485.2020.v4.i2d.174","volume":"4","author":"P Rath","year":"2020","unstructured":"Rath P (2020) A case of infertility due to PCOS treated successfully with homoeopathy. Int J Homoeopath Sci 4:249\u2013260","journal-title":"Int J Homoeopath Sci"},{"key":"10223_CR15","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00404-019-05202-z","volume":"300","author":"P Angin","year":"2019","unstructured":"Angin P, Yoldemir T, Atasayan K (2019) Quality of life among infertile PCOS patients. Arch Gynecol Obstet 300:461\u2013467. https:\/\/doi.org\/10.1007\/s00404-019-05202-z","journal-title":"Arch Gynecol Obstet"},{"key":"10223_CR16","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1038\/ijo.2017.126","volume":"41","author":"A Couto Alves","year":"2017","unstructured":"Couto Alves A, Valcarcel B, M\u00e4kinen VP et al (2017) Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity. Int J Obes 41:1331\u20131340. https:\/\/doi.org\/10.1038\/ijo.2017.126","journal-title":"Int J Obes"},{"key":"10223_CR17","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.amjmed.2014.04.017","volume":"127","author":"TL Setji","year":"2014","unstructured":"Setji TL, Brown AJ (2014) Polycystic ovary syndrome: update on diagnosis and treatment. Am J Med 127:912\u2013919","journal-title":"Am J Med"},{"key":"10223_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.mehy.2012.04.016","volume":"79","author":"K Tremellen","year":"2012","unstructured":"Tremellen K, Pearce K (2012) Dysbiosis of gut microbiota (DOGMA) - a novel theory for the development of Polycystic Ovarian Syndrome. Med Hypotheses 79:104\u2013112. https:\/\/doi.org\/10.1016\/j.mehy.2012.04.016","journal-title":"Med Hypotheses"},{"issue":"9","key":"10223_CR19","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1080\/10408398.2016.1269054","volume":"58","author":"MG Valle Gottlieb","year":"2018","unstructured":"Valle Gottlieb MG, Closs VE, Junges VM, Schwanke CHA (2018) Impact of human aging and modern lifestyle on gut microbiota. Crit Rev Food Sci Nutr 58(9):1557\u20131564. https:\/\/doi.org\/10.1080\/10408398.2016.1269054. Epub 2017 Jul 21. PMID: 28085494","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10223_CR20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.alit.2017.08.004","volume":"66","author":"Y Yamazaki","year":"2017","unstructured":"Yamazaki Y, Nakamura Y, N\u00fa\u00f1ez G (2017) Role of the microbiota in skin immunity and atopic dermatitis. Allergol Int 66:539\u2013544","journal-title":"Allergol Int"},{"key":"10223_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cmi.2018.04.019","volume":"25","author":"J Tamarelle","year":"2019","unstructured":"Tamarelle J, Thi\u00e9baut ACM, de Barbeyrac B et al (2019) The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: a systematic review and meta-analysis. Clin Microbiol Infect 25:35\u201347","journal-title":"Clin Microbiol Infect"},{"key":"10223_CR22","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.cell.2015.03.033","volume":"161","author":"V Ridaura","year":"2015","unstructured":"Ridaura V, Belkaid Y (2015) Gut microbiota: the link to your second brain. Cell 161:193\u2013194","journal-title":"Cell"},{"issue":"1","key":"10223_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/fermentation7010010","volume":"7","author":"V Lolou","year":"2021","unstructured":"Lolou V (2021) The Role of Probiotics and Synbiotics on Hirsutism. Fermentation 7(1):10. https:\/\/doi.org\/10.3390\/fermentation7010010","journal-title":"Fermentation"},{"key":"10223_CR24","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/1574-6976.12075","volume":"38","author":"M Rajili\u0107-Stojanovi\u0107","year":"2014","unstructured":"Rajili\u0107-Stojanovi\u0107 M, de Vos WM (2014) The first 1000 cultured species of the human gastrointestinal microbiota. FEMS Microbiol Rev 38:996\u20131047. https:\/\/doi.org\/10.1111\/1574-6976.12075","journal-title":"FEMS Microbiol Rev"},{"key":"10223_CR25","doi-asserted-by":"publisher","first-page":"5281","DOI":"10.1007\/s00203-021-02516-y","volume":"203","author":"S Ghosh","year":"2021","unstructured":"Ghosh S, Pramanik S (2021) Structural diversity, functional aspects and future therapeutic applications of human gut microbiome. Arch Microbiol 203:5281\u20135308","journal-title":"Arch Microbiol"},{"key":"10223_CR26","doi-asserted-by":"publisher","first-page":"8836","DOI":"10.3748\/wjg.v21.i29.8787","volume":"21","author":"SM Jandhyala","year":"2015","unstructured":"Jandhyala SM, Talukdar R, Subramanyam C et al (2015) Role of the normal gut microbiota. World J Gastroenterol 21:8836\u20138847. https:\/\/doi.org\/10.3748\/wjg.v21.i29.8787","journal-title":"World J Gastroenterol"},{"key":"10223_CR27","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","volume":"165","author":"A Koh","year":"2016","unstructured":"Koh A, De Vadder F, Kovatcheva-Datchary P, B\u00e4ckhed F (2016) From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165:1332\u20131345","journal-title":"Cell"},{"key":"10223_CR28","doi-asserted-by":"publisher","first-page":"253","DOI":"10.12989\/sem.2011.37.2.253","volume":"37","author":"F Abed-Meraim","year":"2011","unstructured":"Abed-Meraim F, Combescure A (2011) New prismatic solid-shell element: assumed strain formulation and hourglass mode analysis. Struct Eng Mech 37:253\u2013256. https:\/\/doi.org\/10.12989\/sem.2011.37.2.253","journal-title":"Struct Eng Mech"},{"key":"10223_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biology9080203","volume":"9","author":"L Yang","year":"2020","unstructured":"Yang L, Lin H, Lin W, Xu X (2020) Exercise ameliorates insulin resistance of type 2 diabetes through motivating short-chain fatty acid-mediated skeletal muscle cell autophagy. Biology (Basel) 9:1\u201318. https:\/\/doi.org\/10.3390\/biology9080203","journal-title":"Biology (Basel)"},{"key":"10223_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14650","author":"J Gajewski","year":"2017","unstructured":"Gajewski J, Pavlovic R, Fischer M et al (2017) Engineering fungal de novo fatty acid synthesis for short chain fatty acid production. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms14650","journal-title":"Nat Commun"},{"issue":"4","key":"10223_CR31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4103\/tcmj.tcmj_86_23","volume":"35","author":"CY Chen","year":"2023","unstructured":"Chen CY, Ho HC (2023) Roles of gut microbes in metabolic-associated fatty liver disease. Tzu Chi Med J 35(4):279\u2013289. https:\/\/doi.org\/10.4103\/tcmj.tcmj_86_23. PMID: 38035063; PMCID: PMC10683521","journal-title":"Tzu Chi Med J"},{"key":"10223_CR32","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1097\/MEG.0000000000001489","volume":"31","author":"T Attila","year":"2019","unstructured":"Attila T, Adsay V, Faigel DO (2019) Response to: The efficacy and safety of endoscopic ultrasound-guided ablation of pancreatic cysts with alcohol and paclitaxel: a systematic review. Eur J Gastroenterol Hepatol 31:1475","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10223_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900521","author":"S Yan","year":"2019","unstructured":"Yan S, Shi R, Li L et al (2019) Mannan oligosaccharide suppresses lipid accumulation and appetite in western-diet-induced obese mice via reshaping gut microbiome and enhancing short-chain fatty acids production. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.201900521","journal-title":"Mol Nutr Food Res"},{"key":"10223_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21239212","volume":"21","author":"M Szczuko","year":"2020","unstructured":"Szczuko M, Kikut J, Maciejewska D et al (2020) The associations of SCFA with anthropometric parameters and carbohydrate metabolism in pregnant women. Int J Mol Sci 21:1\u201312. https:\/\/doi.org\/10.3390\/ijms21239212","journal-title":"Int J Mol Sci"},{"issue":"Suppl 2","key":"10223_CR35","first-page":"251","volume":"59","author":"H Tazoe","year":"2008","unstructured":"Tazoe H, Otomo Y, Kaji I, Tanaka R, Karaki SI, Kuwahara A (2008) Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol 59(Suppl 2):251\u2013262. PMID: 18812643","journal-title":"J Physiol Pharmacol"},{"key":"10223_CR36","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","volume":"27","author":"HM Hamer","year":"2008","unstructured":"Hamer HM, Jonkers D, Venema K et al (2008) Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 27:104\u2013119","journal-title":"Aliment Pharmacol Ther"},{"key":"10223_CR37","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fmicb.2016.00185","volume":"7","author":"D R\u00edos-Covi\u00e1n","year":"2016","unstructured":"R\u00edos-Covi\u00e1n D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavil\u00e1n CG, Salazar N (2016) Intestinal short chain fatty acids and their link with diet and human health. Front Microbiol 7:185. https:\/\/doi.org\/10.3389\/fmicb.2016.00185. PMID: 26925050; PMCID: PMC4756104","journal-title":"Front Microbiol"},{"key":"10223_CR38","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","volume":"63","author":"K Machiels","year":"2014","unstructured":"Machiels K, Joossens M, Sabino J et al (2014) A decrease of the butyrate-producing species roseburia hominis and faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut 63:1275\u20131283. https:\/\/doi.org\/10.1136\/gutjnl-2013-304833","journal-title":"Gut"},{"key":"10223_CR39","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1194\/jlr.R036012","volume":"54","author":"G Den Besten","year":"2013","unstructured":"Den Besten G, Van Eunen K, Groen AK et al (2013) The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 54:2325\u20132340","journal-title":"J Lipid Res"},{"key":"10223_CR40","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02153\/4822208","author":"PJ Torres","year":"2018","unstructured":"Torres PJ, Siakowska M, Banaszewska B et al (2018) Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/jc.2017-02153\/4822208","journal-title":"J Clin Endocrinol Metab"},{"key":"10223_CR41","doi-asserted-by":"publisher","first-page":"711137","DOI":"10.3389\/fmicb.2021.711137","volume":"12","author":"S He","year":"2021","unstructured":"He S, Li H, Yu Z, Zhang F, Liang S, Liu H, Chen H, L\u00fc M (2021) The gut microbiome and sex hormone-related diseases. Front Microbiol 12:711137. https:\/\/doi.org\/10.3389\/fmicb.2021.711137. PMID: 34650525; PMCID: PMC8506209","journal-title":"Front Microbiol"},{"issue":"8","key":"10223_CR42","doi-asserted-by":"publisher","first-page":"dgw029","DOI":"10.1093\/jnci\/djw029","volume":"108","author":"M Kwa","year":"2016","unstructured":"Kwa M, Plottel CS, Blaser MJ, Adams S (2016) The intestinal microbiome and estrogen receptor-positive female breast cancer. J Natl Cancer Inst 108(8):dgw029. https:\/\/doi.org\/10.1093\/jnci\/djw029. PMID: 27107051; PMCID: PMC5017946","journal-title":"J Natl Cancer Inst"},{"key":"10223_CR43","doi-asserted-by":"publisher","first-page":"667422","DOI":"10.3389\/fendo.2021.667422","volume":"12","author":"B Liao","year":"2021","unstructured":"Liao B, Qiao J, Pang Y (2021) Central regulation of PCOS: Abnormal neuronal-reproductive-metabolic circuits in PCOS pathophysiology. Front Endocrinol (Lausanne) 12:667422. https:\/\/doi.org\/10.3389\/fendo.2021.667422. PMID: 34122341; PMCID: PMC8194358","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10223_CR44","doi-asserted-by":"publisher","first-page":"314","DOI":"10.5056\/jnm20208","volume":"27","author":"K Yoon","year":"2021","unstructured":"Yoon K, Kim N (2021) Roles of sex hormones and gender in the Gut Microbiota. J Neurogastroenterol Motil 27:314\u2013325","journal-title":"J Neurogastroenterol Motil"},{"key":"10223_CR45","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cellsig.2013.11.037","volume":"26","author":"H Tao","year":"2014","unstructured":"Tao H, Shi KH, Yang JJ et al (2014) Histone deacetylases in cardiac fibrosis: current perspectives for therapy. Cell Signal 26:521\u2013527","journal-title":"Cell Signal"},{"key":"10223_CR46","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1073\/pnas.1322269111","volume":"111","author":"PV Chang","year":"2014","unstructured":"Chang PV, Hao L, Offermanns S, Medzhitov R (2014) The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A 111:2247\u20132252. https:\/\/doi.org\/10.1073\/pnas.1322269111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10223_CR47","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.tips.2013.02.002","volume":"34","author":"LB Bindels","year":"2013","unstructured":"Bindels LB, Dewulf EM, Delzenne NM (2013) GPR43\/FFA2: physiopathological relevance and therapeutic prospects. Trends Pharmacol Sci 34:226\u2013232","journal-title":"Trends Pharmacol Sci"},{"key":"10223_CR48","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.tim.2021.02.001","volume":"29","author":"B van der Hee","year":"2021","unstructured":"van der Hee B, Wells JM (2021) Microbial regulation of host physiology by short-chain fatty acids. Trends Microbiol 29:700\u2013712","journal-title":"Trends Microbiol"},{"issue":"17","key":"10223_CR49","doi-asserted-by":"publisher","first-page":"9641","DOI":"10.3390\/ijms22179641","volume":"22","author":"A Zaky","year":"2021","unstructured":"Zaky A, Glastras SJ, Wong MYW, Pollock CA, Saad S (2021) The role of the gut microbiome in diabetes and obesity-related kidney disease. Int J Mol Sci 22(17):9641. https:\/\/doi.org\/10.3390\/ijms22179641. PMID: 34502562; PMCID: PMC8431784","journal-title":"Int J Mol Sci"},{"key":"10223_CR50","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","volume":"121","author":"J Tan","year":"2014","unstructured":"Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L (2014) The role of short-chain fatty acids in health and disease. Adv Immunol 121:91\u2013119. https:\/\/doi.org\/10.1016\/B978-0-12-800100-4.00003-9. PMID: 24388214","journal-title":"Adv Immunol"},{"key":"10223_CR51","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.kint.2016.06.033","volume":"90","author":"JL Pluznick","year":"2016","unstructured":"Pluznick JL (2016) Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors. Kidney Int 90:1191\u20131198","journal-title":"Kidney Int"},{"key":"10223_CR52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/dmrr.2514","volume":"30","author":"S Balducci","year":"2014","unstructured":"Balducci S, Sacchetti M, Haxhi J et al (2014) Physical exercise as therapy for type 2 diabetes mellitus. Diabetes Metab Res Rev 30:13\u201323","journal-title":"Diabetes Metab Res Rev"},{"issue":"1","key":"10223_CR53","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/biomedicines8010008","volume":"8","author":"AK Sikalidis","year":"2020","unstructured":"Sikalidis AK, Maykish A (2020) The gut microbiome and Type 2 diabetes mellitus: Discussing a complex relationship. Biomedicines 8(1):8. https:\/\/doi.org\/10.3390\/biomedicines8010008. PMID: 31936158; PMCID: PMC7168169","journal-title":"Biomedicines"},{"key":"10223_CR54","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09718-3","volume-title":"Diagnosis and management of polycystic ovary syndrome","author":"NR Farid","year":"2009","unstructured":"Farid NR, Diamanti-Kandarakis E (2009) Diagnosis and management of polycystic ovary syndrome. Springer, US"},{"issue":"1","key":"10223_CR55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1089\/jwh.2010.2053","volume":"20","author":"DW Stovall","year":"2011","unstructured":"Stovall DW, Bailey AP, Pastore LM (2011) Assessment of insulin resistance and impaired glucose tolerance in lean women with polycystic ovary syndrome. J Womens Health (Larchmt) 20(1):37\u201343. https:\/\/doi.org\/10.1089\/jwh.2010.2053. Epub 2010 Dec 31. PMID: 21194310; PMCID: PMC3026650","journal-title":"J Womens Health (Larchmt)"},{"issue":"1","key":"10223_CR56","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s13643-019-1145-y","volume":"8","author":"T Rittiphairoj","year":"2019","unstructured":"Rittiphairoj T, Pongpirul K, Mueller NT, Li T (2019) Probiotics for glycemic control in patients with type 2 diabetes mellitus: protocol for a systematic review. Syst Rev 8(1):227. https:\/\/doi.org\/10.1186\/s13643-019-1145-y. PMID: 31481125; PMCID: PMC6720889","journal-title":"Syst Rev"},{"key":"10223_CR57","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1017\/S0007114509991863","volume":"103","author":"KR Freeland","year":"2010","unstructured":"Freeland KR, Wolever TMS (2010) Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-\u03b1. Br J Nutr 103:460\u2013466. https:\/\/doi.org\/10.1017\/S0007114509991863","journal-title":"Br J Nutr"},{"key":"10223_CR58","doi-asserted-by":"publisher","first-page":"S46","DOI":"10.1097\/MCG.0000000000001058","volume":"52","author":"M Pane","year":"2018","unstructured":"Pane M, Amoruso A, Deidda F et al (2018) Gut microbiota, probiotics, and sport from clinical evidence to agonistic performance. J Clin Gastroenterol 52:S46\u2013S49. https:\/\/doi.org\/10.1097\/MCG.0000000000001058","journal-title":"J Clin Gastroenterol"},{"key":"10223_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168390","author":"L Lindheim","year":"2017","unstructured":"Lindheim L, Bashir M, M\u00fcnzker J et al (2017) Alterations in gut microbiome composition and barrier function are associated with reproductive and metabolic defects in women with polycystic ovary syndrome (PCOS): a pilot study. PLoS One. https:\/\/doi.org\/10.1371\/journal.pone.0168390","journal-title":"PLoS One"},{"issue":"2","key":"10223_CR60","doi-asserted-by":"publisher","first-page":"bvaa177","DOI":"10.1210\/jendso\/bvaa177","volume":"5","author":"MG Rizk","year":"2020","unstructured":"Rizk MG, Thackray VG (2020) Intersection of Polycystic Ovary Syndrome and the Gut Microbiome. J Endocr Soc 5(2):bvaa177. https:\/\/doi.org\/10.1210\/jendso\/bvaa177. PMID: 33381671; PMCID: PMC7757431","journal-title":"J Endocr Soc"},{"issue":"7","key":"10223_CR61","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1210\/jc.2017-02799","volume":"103","author":"M Insenser","year":"2018","unstructured":"Insenser M, Murri M, Del Campo R, Mart\u00ednez-Garc\u00eda M\u00c1, Fern\u00e1ndez-Dur\u00e1n E, Escobar-Morreale HF (2018) Gut microbiota and the polycystic ovary syndrome: influence of sex, sex hormones, and obesity. J Clin Endocrinol Metab 103(7):2552\u20132562. https:\/\/doi.org\/10.1210\/jc.2017-02799. PMID: 29897462","journal-title":"J Clin Endocrinol Metab"},{"key":"10223_CR62","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.chom.2013.08.006","volume":"14","author":"CA Lozupone","year":"2013","unstructured":"Lozupone CA, Li M, Campbell TB et al (2013) Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe 14:329\u2013339. https:\/\/doi.org\/10.1016\/j.chom.2013.08.006","journal-title":"Cell Host Microbe"},{"key":"10223_CR63","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00017-19","author":"J Zhang","year":"2019","unstructured":"Zhang J, Sun Z, Jiang S et al (2019) Probiotic Bifidobacterium lactis V9 regulates the secretion of sex hormones in polycystic ovary syndrome patients through the gut-brain axis. mSystems. https:\/\/doi.org\/10.1128\/msystems.00017-19","journal-title":"mSystems"},{"key":"10223_CR64","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.fertnstert.2020.01.027","volume":"113","author":"W Chu","year":"2020","unstructured":"Chu W, Han Q, Xu J et al (2020) Metagenomic analysis identified microbiome alterations and pathological association between intestinal microbiota and polycystic ovary syndrome. Fertil Steril 113:1286\u20131298.e4. https:\/\/doi.org\/10.1016\/j.fertnstert.2020.01.027","journal-title":"Fertil Steril"},{"key":"10223_CR65","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2147\/DMSO.S29244","volume":"5","author":"BT Layden","year":"2012","unstructured":"Layden BT, Yalamanchi SK, Wolever TMS et al (2012) Negative association of acetate with visceral adipose tissue and insulin levels. Diabetes, Metabolic Syndrome and Obesity 5:49\u201355. https:\/\/doi.org\/10.2147\/DMSO.S29244","journal-title":"Diabetes, Metabolic Syndrome and Obesity"},{"key":"10223_CR66","doi-asserted-by":"crossref","unstructured":"Markowiak-Kope\u0107 P, \u015ali\u017cewska K (2020) The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome. Nutrients 12","DOI":"10.3390\/nu12041107"},{"key":"10223_CR67","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1042\/CS20171055","volume":"132","author":"P St\u00e4rkel","year":"2018","unstructured":"St\u00e4rkel P, Leclercq S, de Timary P, Schnabl B (2018) Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease. Clin Sci 132:199\u2013212","journal-title":"Clin Sci"},{"key":"10223_CR68","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1080\/13102818.2018.1481350","volume":"32","author":"H Wang","year":"2018","unstructured":"Wang H, Wei CX, Min L, Zhu LY (2018) Good or bad: gut bacteria in human health and diseases. Biotechnol Biotechnol Equip 32:1075\u20131080","journal-title":"Biotechnol Biotechnol Equip"},{"key":"10223_CR69","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.858902","author":"ZJ Dong","year":"2022","unstructured":"Dong ZJ, Lv WQ, Zhang CY, Chen S (2022) Correlation analysis of gut microbiota and serum metabolome with Porphyromonas gingivalis-induced metabolic disorders. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2022.858902","journal-title":"Front Cell Infect Microbiol"},{"issue":"7","key":"10223_CR70","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"PD Cani","year":"2007","unstructured":"Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delm\u00e9e E, Cousin B, Sulpice T, Chamontin B, Ferri\u00e8res J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56(7):1761\u20131772. https:\/\/doi.org\/10.2337\/db06-1491. Epub 2007 Apr 24 PMID: 17456850","journal-title":"Diabetes"},{"key":"10223_CR71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153196","author":"Y Guo","year":"2016","unstructured":"Guo Y, Qi Y, Yang X et al (2016) Association between polycystic ovary syndrome and gut microbiota. PLoS One. https:\/\/doi.org\/10.1371\/journal.pone.0153196","journal-title":"PLoS One"},{"key":"10223_CR72","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nrgastro.2016.4","volume":"13","author":"RE Ley","year":"2016","unstructured":"Ley RE (2016) Gut microbiota in 2015: Prevotella in the gut: choose carefully. Nat Rev Gastroenterol Hepatol 13:69","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10223_CR73","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jsbmb.2018.04.008","volume":"182","author":"S Patel","year":"2018","unstructured":"Patel S (2018) Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol 182:27\u201336. https:\/\/doi.org\/10.1016\/j.jsbmb.2018.04.008. Epub 2018 Apr 17. PMID: 29678491","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10223_CR74","doi-asserted-by":"publisher","unstructured":"Probiotic Bifidobacterium lactis V9 regulates the intestinal microbiome in patients with polycystic ovary syndrome. Zhang J, Sun Z, Jiang S, Bai X, Ma C, Peng Q, Chen K, Chang H, Fang T, Zhang H (2019) Probiotic Bifidobacterium lactis V9 regulates the secretion of sex hormones in polycystic ovary syndrome patients through the gut-brain Axis. Am Soc Microbiol 4:360\u2013368. https:\/\/doi.org\/10.1360\/N972018-00587","DOI":"10.1360\/N972018-00587"},{"key":"10223_CR75","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.rbmo.2023.03.016","volume":"47","author":"A Sola-Leyva","year":"2023","unstructured":"Sola-Leyva A, P\u00e9rez-Prieto I, Molina NM et al (2023) Microbial composition across body sites in polycystic ovary syndrome: a systematic review and meta-analysis. Reprod Biomed Online 47:129\u2013150. https:\/\/doi.org\/10.1016\/j.rbmo.2023.03.016","journal-title":"Reprod Biomed Online"},{"key":"10223_CR76","first-page":"71","volume":"4","author":"RJ Palframan","year":"2003","unstructured":"Palframan RJ, Gibson GR, Rastall RA (2003) Carbohydrate preferences of Bifidobacterium species isolated from the human gut. Curr Issues Intest Microbiol 4:71\u201375","journal-title":"Curr Issues Intest Microbiol"},{"key":"10223_CR77","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2219342","author":"J Gan","year":"2023","unstructured":"Gan J, Chen J, Ma RL et al (2023) Metagenomics study on taxonomic and functional change of gut microbiota in patients with obesity with PCOS treated with exenatide combination with metformin or metformin alone. Gynecol Endocrinol. https:\/\/doi.org\/10.1080\/09513590.2023.2219342","journal-title":"Gynecol Endocrinol"},{"key":"10223_CR78","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/19490976.2017.1406584","volume":"9","author":"LF Gomez-Arango","year":"2018","unstructured":"Gomez-Arango LF, Barrett HL, Wilkinson SA et al (2018) Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women. Gut Microbes 9:189\u2013201. https:\/\/doi.org\/10.1080\/19490976.2017.1406584","journal-title":"Gut Microbes"},{"key":"10223_CR79","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.resmic.2018.09.002","volume":"170","author":"B Zeng","year":"2019","unstructured":"Zeng B, Lai Z, Sun L et al (2019) Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study. Res Microbiol 170:43\u201352. https:\/\/doi.org\/10.1016\/j.resmic.2018.09.002","journal-title":"Res Microbiol"},{"key":"10223_CR80","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","volume":"25","author":"X Qi","year":"2019","unstructured":"Qi X, Yun C, Sun L et al (2019) Gut microbiota\u2013bile acid\u2013interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med 25:1225\u20131233. https:\/\/doi.org\/10.1038\/s41591-019-0509-0","journal-title":"Nat Med"},{"key":"10223_CR81","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.fertnstert.2020.01.027","volume":"113","author":"W Chu","year":"2020","unstructured":"Chu W, Han Q, Xu J et al (2020) Metagenomic analysis identified intestinal microbiota and polycystic pathological association between microbiome alterations and ovary syndrome. Fertil Steril 113:1286\u20131298.e4. https:\/\/doi.org\/10.1016\/j.fertnstert.2020.01.027","journal-title":"Fertil Steril"},{"key":"10223_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu12061622","volume":"12","author":"C Haudum","year":"2020","unstructured":"Haudum C, Lindheim L, Ascani A et al (2020) Impact of short-term isoflavone intervention in polycystic ovary syndrome (PCOS) patients on microbiota composition and metagenomics. Nutrients 12:1\u201322. https:\/\/doi.org\/10.3390\/nu12061622","journal-title":"Nutrients"},{"key":"10223_CR83","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1472-765X.2008.02346.x","volume":"46","author":"M Pogribna","year":"2008","unstructured":"Pogribna M, Freeman JP, Paine D, Boudreau MD (2008) Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum. Lett Appl Microbiol 46:575\u2013580. https:\/\/doi.org\/10.1111\/j.1472-765X.2008.02346.x","journal-title":"Lett Appl Microbiol"},{"key":"10223_CR84","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1210\/clinem\/dgz263","volume":"105","author":"B Jobira","year":"2020","unstructured":"Jobira B, Frank DN, Pyle L et al (2020) Obese adolescents with PCOS have altered biodiversity and relative abundance in gastrointestinal microbiota. J Clin Endocrinol Metab 105:2134\u20132144. https:\/\/doi.org\/10.1210\/clinem\/dgz263","journal-title":"J Clin Endocrinol Metab"},{"key":"10223_CR85","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1210\/jc.2017-02153","volume":"103","author":"PJ Torres","year":"2018","unstructured":"Torres PJ, Siakowska M, Banaszewska B et al (2018) Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism. J Clin Endocrinol Metab 103:1502\u20131511. https:\/\/doi.org\/10.1210\/jc.2017-02153","journal-title":"J Clin Endocrinol Metab"},{"key":"10223_CR86","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1161\/HYPERTENSIONAHA.116.07910","volume":"68","author":"LF Gomez-Arango","year":"2016","unstructured":"Gomez-Arango LF, Barrett HL, McIntyre HD et al (2016) Increased systolic and diastolic blood pressure is associated with altered gut microbiota composition and butyrate production in early pregnancy. Hypertension 68:974\u2013981. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.116.07910","journal-title":"Hypertension"},{"issue":"1","key":"10223_CR87","doi-asserted-by":"publisher","first-page":"1922241","DOI":"10.1080\/19490976.2021.1922241","volume":"13","author":"JC Ezeji","year":"2021","unstructured":"Ezeji JC, Sarikonda DK, Hopperton A, Erkkila HL, Cohen DE, Martinez SP, Cominelli F, Kuwahara T, Dichosa AEK, Good CE, Jacobs MR, Khoretonenko M, Veloo A, Rodriguez-Palacios A (2021) Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health. Gut Microbes 13(1):1922241. https:\/\/doi.org\/10.1080\/19490976.2021.1922241. PMID: 34196581; PMCID: PMC8253142","journal-title":"Gut Microbes"},{"key":"10223_CR88","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.2741\/2363","volume":"12","author":"A Amano","year":"2007","unstructured":"Amano A (2007) Disruption of epithelial barrier and impairment of cellular function by Porphyromonas gingivalis. Front Biosci 12:3965\u20133974. https:\/\/doi.org\/10.2741\/2363","journal-title":"Front Biosci"},{"key":"10223_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2022.858902","volume":"12","author":"ZJ Dong","year":"2022","unstructured":"Dong ZJ, Lv WQ, Zhang CY, Chen S (2022) Correlation analysis of gut microbiota and serum metabolome with Porphyromonas gingivalis-induced metabolic disorders. Front Cell Infect Microbiol 12:1\u201313. https:\/\/doi.org\/10.3389\/fcimb.2022.858902","journal-title":"Front Cell Infect Microbiol"},{"key":"10223_CR90","doi-asserted-by":"publisher","unstructured":"Le ARTIC, Torres PJ, Siakowska M et al (2018) Gut microbial diversity in women with polycystic ovary. 103:1502\u20131511. https:\/\/doi.org\/10.1210\/jc.2017-02153","DOI":"10.1210\/jc.2017-02153"},{"key":"10223_CR91","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1530\/EC-19-0522","volume":"9","author":"L Zhou","year":"2020","unstructured":"Zhou L, Ni Z, Cheng W et al (2020) Characteristic gut microbiota and predicted metabolic functions in women with PCOS. Endocr Connect 9:63\u201373. https:\/\/doi.org\/10.1530\/EC-19-0522","journal-title":"Endocr Connect"},{"key":"10223_CR92","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/1348-0421.12749","volume":"64","author":"A Li","year":"2020","unstructured":"Li A, li, Ni W wei, Zhang Q min, et al (2020) Effect of cinnamon essential oil on gut microbiota in the mouse model of dextran sodium sulfate-induced colitis. Microbiol Immunol 64:23\u201332. https:\/\/doi.org\/10.1111\/1348-0421.12749","journal-title":"Microbiol Immunol"},{"key":"10223_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-02995-4","volume":"7","author":"T Chen","year":"2017","unstructured":"Chen T, Long W, Zhang C et al (2017) Fiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota. Sci Rep 7:1\u20137. https:\/\/doi.org\/10.1038\/s41598-017-02995-4","journal-title":"Sci Rep"},{"key":"10223_CR94","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3389\/fmicb.2017.00324","volume":"8","author":"R Liu","year":"2017","unstructured":"Liu R, Zhang C, Shi Y, Zhang F, Li L, Wang X, Ling Y, Fu H, Dong W, Shen J, Reeves A, Greenberg AS, Zhao L, Peng Y, Ding X (2017) Dysbiosis of gut microbiota associated with clinical parameters in polycystic ovary syndrome. Front Microbiol 8:324. https:\/\/doi.org\/10.3389\/fmicb.2017.00324. PMID: 28293234; PMCID: PMC5328957","journal-title":"Front Microbiol"},{"key":"10223_CR95","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s12916-023-02975-8","volume":"21","author":"P Li","year":"2023","unstructured":"Li P, Shuai P, Shen S et al (2023) Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis. BMC Med 21:302. https:\/\/doi.org\/10.1186\/s12916-023-02975-8","journal-title":"BMC Med"},{"key":"10223_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2022.854796","volume":"12","author":"H Zhao","year":"2022","unstructured":"Zhao H, Chen R, Zheng D et al (2022) Modified Banxia Xiexin decoction ameliorates polycystic ovarian syndrome with insulin resistance by regulating intestinal microbiota. Front Cell Infect Microbiol 12:1\u201312. https:\/\/doi.org\/10.3389\/fcimb.2022.854796","journal-title":"Front Cell Infect Microbiol"},{"key":"10223_CR97","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1080\/21505594.2021.1886777","volume":"12","author":"I Mehdizadeh Gohari","year":"2021","unstructured":"Mehdizadeh Gohari I, A. Navarro M, Li J et al (2021) Pathogenicity and virulence of Clostridium perfringens. Virulence 12:723\u2013753. https:\/\/doi.org\/10.1080\/21505594.2021.1886777","journal-title":"Virulence"},{"key":"10223_CR98","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00017-19","author":"J Zhang","year":"2019","unstructured":"Zhang J, Sun Z, Jiang S et al (2019) Probiotic Bifidobacterium lactis V9 regulates the secretion of sex hormones in polycystic ovary syndrome patients through the gut-brain axis. mSystems. https:\/\/doi.org\/10.1128\/msystems.00017-19","journal-title":"mSystems"},{"key":"10223_CR99","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01642","author":"CA Devaux","year":"2020","unstructured":"Devaux CA, Million M, Raoult D (2020) The butyrogenic and lactic bacteria of the gut microbiota determine the outcome of allogenic hematopoietic cell transplant. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2020.01642","journal-title":"Front Microbiol"},{"key":"10223_CR100","doi-asserted-by":"publisher","unstructured":"Le ARTIC, Murri M, Campo R et al (2018) Gut microbiota and the polycystic ovary syndrome: Influence of sex, sex hormones, and obesity. 103:2552\u20132562. https:\/\/doi.org\/10.1210\/jc.2017-02799","DOI":"10.1210\/jc.2017-02799"},{"key":"10223_CR101","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/mnfr.200700523","volume":"83","author":"ML Stewart","year":"2009","unstructured":"Stewart ML, Savarino V, Slavin JL (2009) Assessment of dietary fiber fermentation\u202f: effect of Lactobacillus reuteri and reproducibility of short-chain fatty acid concentrations. Nutr Food Res 83:114\u2013120. https:\/\/doi.org\/10.1002\/mnfr.200700523","journal-title":"Nutr Food Res"},{"key":"10223_CR102","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1139\/cjpp-2019-0413","volume":"98","author":"Y Liang","year":"2020","unstructured":"Liang Y, Ming Q, Liang J et al (2020) Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity \u2014 a preliminary report. Can J Physiol Pharmacol 98:803\u2013809. https:\/\/doi.org\/10.1139\/cjpp-2019-0413","journal-title":"Can J Physiol Pharmacol"},{"key":"10223_CR103","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s00253-002-1078-5","volume":"60","author":"KTAKK Sonomoto","year":"2002","unstructured":"Sonomoto KTAKK, Stanbury AISJHPF (2002) Two different pathways for D-xylose metabolism and the effect of xylose concentration on the yield coefficient of L-lactate in mixed-acid fermentation by the lactic acid bacterium Lactococcus lactis IO-1. Microbiol Biotechnol 60:160\u2013167. https:\/\/doi.org\/10.1007\/s00253-002-1078-5","journal-title":"Microbiol Biotechnol"},{"key":"10223_CR104","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.idairyj.2009.10.005","volume":"20","author":"R Iyer","year":"2010","unstructured":"Iyer R, Tomar SK, Maheswari TU, Singh R (2010) Streptococcus thermophilus strains\u202f: multifunctional lactic acid bacteria. Int Dairy J 20:133\u2013141. https:\/\/doi.org\/10.1016\/j.idairyj.2009.10.005","journal-title":"Int Dairy J"},{"key":"10223_CR105","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/B978-0-12-397048-0.00008-5","volume":"2","author":"N Boisen","year":"2005","unstructured":"Boisen N, Krogfelt KA, Nataro JP (2005) Enteroaggregative Escherichia coli Gastrointestinal infections nization 2:4\u20138. https:\/\/doi.org\/10.1016\/B978-0-12-397048-0.00008-5","journal-title":"Enteroaggregative Escherichia coli Gastrointestinal infections nization"},{"key":"10223_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2016.00038","volume":"6","author":"SA Killackey","year":"2016","unstructured":"Killackey SA, Sorbara MT, Girardin SE (2016) Cellular aspects of Shigella pathogenesis: focus on the manipulation of host cell processes. Front Cell Infect Microbiol 6:38. https:\/\/doi.org\/10.3389\/fcimb.2016.00038. PMID: 27066460; PMCID: PMC4814626","journal-title":"Front Cell Infect Microbiol"},{"key":"10223_CR107","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1080\/19490976.2018.1441664","volume":"9","author":"SB Sherman","year":"2018","unstructured":"Sherman SB, Sarsour N, Salehi M et al (2018) Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. Gut Microbes 9:400\u2013421. https:\/\/doi.org\/10.1080\/19490976.2018.1441664","journal-title":"Gut Microbes"},{"key":"10223_CR108","doi-asserted-by":"crossref","unstructured":"Herman R, Sikonja J, Jensterle M et al (2023) Insulin metabolism in polycystic ovary syndrome: Secretion, signaling, and clearance. Int J Mol Sci 24","DOI":"10.3390\/ijms24043140"},{"key":"10223_CR109","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/humrep\/deh098","volume":"19","author":"BCJM Fauser","year":"2004","unstructured":"Fauser BCJM, Tarlatzis F et al (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Hum Reprod 19:41\u201347","journal-title":"Hum Reprod"},{"key":"10223_CR110","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1210\/er.2011-1034","volume":"33","author":"E Diamanti-Kandarakis","year":"2012","unstructured":"Diamanti-Kandarakis E, Dunaif A (2012) Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev 33:981\u20131030. https:\/\/doi.org\/10.1210\/er.2011-1034","journal-title":"Endocr Rev"},{"issue":"12","key":"10223_CR111","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1210\/jc.2013-2350","volume":"98","author":"Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK; Endocrine Society","year":"2013","unstructured":"Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK; Endocrine Society (2013) Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 98(12):4565\u20134592. https:\/\/doi.org\/10.1210\/jc.2013-2350. Epub 2013 Oct 22. Erratum in: J Clin Endocrinol Metab. 2021 May 13;106(6):e2462. PMID: 24151290; PMCID: PMC5399492","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10223_CR112","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1017\/S0954422418000136","volume":"31","author":"L Barrea","year":"2018","unstructured":"Barrea L, Marzullo P, Muscogiuri G, Di Somma C, Scacchi M, Orio F, Aimaretti G, Colao A, Savastano S (2018) Source and amount of carbohydrate in the diet and inflammation in women with polycystic ovary syndrome. Nutr Res Rev 31(2):291\u2013301. https:\/\/doi.org\/10.1017\/S0954422418000136. Epub 2018 Jul 23. PMID: 30033891","journal-title":"Nutr Res Rev"},{"key":"10223_CR113","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.molmet.2016.06.002","volume":"5","author":"TPM Scheithauer","year":"2016","unstructured":"Scheithauer TPM, Dallinga-Thie GM, de Vos WM et al (2016) Causality of small and large intestinal microbiota in weight regulation and insulin resistance. Mol Metab 5:759\u2013770. https:\/\/doi.org\/10.1016\/j.molmet.2016.06.002","journal-title":"Mol Metab"},{"key":"10223_CR114","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2337\/dc14-0769","volume":"38","author":"AV Hartstra","year":"2015","unstructured":"Hartstra AV, Bouter KEC, B\u00e4ckhed F, Nieuwdorp M (2015) Insights into the role of the microbiome in obesity and type 2 diabetes. Diabetes Care 38:159\u2013165","journal-title":"Diabetes Care"},{"key":"10223_CR115","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1152\/physiolgenomics.00114","volume":"50","author":"N Jiao","year":"2018","unstructured":"Jiao N, Baker SS, Nugent CA et al (2018) Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiol Genomics 50:244\u2013254. https:\/\/doi.org\/10.1152\/physiolgenomics.00114","journal-title":"Physiol Genomics"},{"key":"10223_CR116","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jsbmb.2018.01.008","volume":"178","author":"M Belani","year":"2018","unstructured":"Belani M, Deo A, Shah P et al (2018) Differential insulin and steroidogenic signaling in insulin resistant and non-insulin resistant human luteinized granulosa cells\u2014a study in PCOS patients. J Steroid Biochem Mol Biol 178:283\u2013292. https:\/\/doi.org\/10.1016\/j.jsbmb.2018.01.008","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"6","key":"10223_CR117","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.3390\/nu13061848","volume":"13","author":"V Calcaterra","year":"2021","unstructured":"Calcaterra V, Verduci E, Cena H, Magenes VC, Todisco CF, Tenuta E, Gregorio C, De Giuseppe R, Bosetti A, Di Profio E, Zuccotti G (2021) Polycystic ovary syndrome in insulin-resistant adolescents with obesity: the role of nutrition therapy and food supplements as a strategy to protect fertility. Nutrients 13(6):1848. https:\/\/doi.org\/10.3390\/nu13061848. PMID: 34071499; PMCID: PMC8228678","journal-title":"Nutrients"},{"key":"10223_CR118","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64776-w","author":"CH Kim","year":"2020","unstructured":"Kim CH, Chon SJ, Lee SH (2020) Effects of lifestyle modification in polycystic ovary syndrome compared to metformin only or metformin addition: a systematic review and meta-analysis. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-020-64776-w","journal-title":"Sci Rep"},{"key":"10223_CR119","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1080\/13102818.2019.1621208","volume":"33","author":"VY Marinova","year":"2019","unstructured":"Marinova VY, Rasheva IK, Kizheva YK et al (2019) Microbiological quality of probiotic dietary supplements. Biotechnol Biotechnol Equip 33:834\u2013841. https:\/\/doi.org\/10.1080\/13102818.2019.1621208","journal-title":"Biotechnol Biotechnol Equip"},{"key":"10223_CR120","doi-asserted-by":"publisher","first-page":"737","DOI":"10.2147\/PPA.S244273","volume":"14","author":"F AlHussain","year":"2020","unstructured":"AlHussain F, AlRuthia Y, Al-Mandeel H, Bellahwal A, Alharbi F, Almogbel Y, Awwad O, Dala\u2019een R, Alharbi FA (2020) Metformin improves the depression symptoms of women with polycystic ovary syndrome in a lifestyle modification program. Patient Prefer Adherence 14:737\u2013746. https:\/\/doi.org\/10.2147\/PPA.S244273. PMID: 32346286; PMCID: PMC7167265","journal-title":"Patient Prefer Adherence"},{"key":"10223_CR121","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1111\/j.1469-0691.2005.01228.x","volume":"11","author":"AC Senok","year":"2005","unstructured":"Senok AC, Ismaeel AY, Botta GA (2005) Probiotics: facts and myths. Clin Microbiol Infect 11:958\u2013966","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"10223_CR122","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11894-019-0740-3","volume":"22","author":"TC Judkins","year":"2020","unstructured":"Judkins TC, Archer DL, Kramer DC, Solch RJ (2020) Probiotics, Nutrition, and the Small Intestine. Curr Gastroenterol Rep 22(1):2. https:\/\/doi.org\/10.1007\/s11894-019-0740-3. PMID: 31930437","journal-title":"Curr Gastroenterol Rep"},{"key":"10223_CR123","doi-asserted-by":"crossref","unstructured":"Mills S, Stanton C, Fitzgerald GF, Ross P (2011) Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again","DOI":"10.1186\/1475-2859-10-S1-S19"},{"key":"10223_CR124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4161\/gmic.1.3.11712","volume":"1","author":"CM Thomas","year":"2010","unstructured":"Thomas CM, Versalovic J (2010) Probiotics-host communication modulation of signaling pathways in the intestine. Gut Microbes 1:1\u201316","journal-title":"Gut Microbes"},{"key":"10223_CR125","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1007\/s00394-020-02233-0","volume":"59","author":"M Cozzolino","year":"2020","unstructured":"Cozzolino M, Vitagliano A, Pellegrini L et al (2020) Therapy with probiotics and synbiotics for polycystic ovarian syndrome: a systematic review and meta-analysis. Eur J Nutr 59:2841\u20132856","journal-title":"Eur J Nutr"},{"key":"10223_CR126","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrendo.2015.128","volume":"11","author":"EE Canfora","year":"2015","unstructured":"Canfora EE, Jocken JW, Blaak EE (2015) Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol 11:577\u2013591. https:\/\/doi.org\/10.1038\/nrendo.2015.128. Epub 2015 Aug 11. PMID: 26260141","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"10223_CR127","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.3390\/nu11081943","volume":"11","author":"MAG Hern\u00e1ndez","year":"2019","unstructured":"Hern\u00e1ndez MAG, Canfora EE, Jocken JWE, Blaak EE (2019) The short-chain fatty acid acetate in body weight control and insulin sensitivity. Nutrients 11(8):1943. https:\/\/doi.org\/10.3390\/nu11081943. PMID: 31426593; PMCID: PMC6723943","journal-title":"Nutrients"},{"key":"10223_CR128","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.2337\/db08-1637","volume":"58","author":"Z Gao","year":"2009","unstructured":"Gao Z, Yin J, Zhang J et al (2009) Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58:1509\u20131517. https:\/\/doi.org\/10.2337\/db08-1637","journal-title":"Diabetes"},{"key":"10223_CR129","unstructured":"Karamali M, Eghbalpour S, Rajabi S et al (2018) Effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial"},{"key":"10223_CR130","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4183\/aeb.2017.431","volume":"13","author":"N Alihosseini","year":"2017","unstructured":"Alihosseini N, Moahboob SA, Farrin N et al (2017) Effect of probiotic fermented milk (KEFIR) on serum level of insulin and homocysteine in type 2 diabetes patients. Acta Endocrinol (Copenh) 13:431\u2013436. https:\/\/doi.org\/10.4183\/aeb.2017.431","journal-title":"Acta Endocrinol (Copenh)"},{"key":"10223_CR131","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2687734","author":"X Wang","year":"2023","unstructured":"Wang X, Wan M, Wang Z et al (2023) Effects of tributyrin supplementation on growth performance, intestinal digestive enzyme activity, antioxidant capacity, and inflammation-related gene expression of Large Yellow Croaker (Larimichthys crocea) fed with a high level of Clostridium autoethanogenum protein. Aquac Nutr. https:\/\/doi.org\/10.1155\/2023\/2687734","journal-title":"Aquac Nutr"},{"key":"10223_CR132","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.3748\/wjg.v13.i20.2826","volume":"13","author":"S Tedelind","year":"2007","unstructured":"Tedelind S, Westberg F, Kjerrulf M, Vidal A (2007) Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease clinical research. World J Gastroenterol 13:2826\u20132832","journal-title":"World J Gastroenterol"},{"key":"10223_CR133","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3390\/nu3100858","volume":"3","author":"MAR Vinolo","year":"2011","unstructured":"Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R (2011) Regulation of inflammation by short chain fatty acids. Nutrients 3:858\u2013876","journal-title":"Nutrients"},{"key":"10223_CR134","doi-asserted-by":"crossref","unstructured":"Serhan M, Sprowls M, Jackemeyer D et al (2019) Total iron measurement in human serum with a smartphone. In: AIChE Annual Meeting, Conference Proceedings. American Institute of Chemical Engineers","DOI":"10.1109\/JTEHM.2020.3005308"},{"key":"10223_CR135","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00394-019-02033-1","volume":"59","author":"SG Shamasbi","year":"2020","unstructured":"Shamasbi SG, Ghanbari-Homayi S, Mirghafourvand M (2020) The effect of probiotics, prebiotics, and synbiotics on hormonal and inflammatory indices in women with polycystic ovary syndrome: a systematic review and meta-analysis. Eur J Nutr 59:433\u2013450","journal-title":"Eur J Nutr"},{"key":"10223_CR136","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jff.2017.06.029","volume":"36","author":"NM Rashad","year":"2017","unstructured":"Rashad NM, El-Shal AS, Amin AI, Soliman MH (2017) Effects of probiotics supplementation on macrophage migration inhibitory factor and clinical laboratory feature of polycystic ovary syndrome. J Funct Foods 36:317\u2013324. https:\/\/doi.org\/10.1016\/j.jff.2017.06.029","journal-title":"J Funct Foods"},{"key":"10223_CR137","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.dsx.2018.04.015","volume":"12","author":"N Kobyliak","year":"2018","unstructured":"Kobyliak N, Falalyeyeva T, Mykhalchyshyn G et al (2018) Effect of alive probiotic on insulin resistance in type 2 diabetes patients: randomized clinical trial. Diabetes Metab Syndr 12:617\u2013624. https:\/\/doi.org\/10.1016\/j.dsx.2018.04.015","journal-title":"Diabetes Metab Syndr"},{"key":"10223_CR138","doi-asserted-by":"crossref","unstructured":"B\u00e4 ckhed F, Ding H, Wang T et al (2004) The gut microbiota as an environmental factor that regulates fat storage","DOI":"10.1073\/pnas.0407076101"},{"key":"10223_CR139","doi-asserted-by":"crossref","unstructured":"Aponte M, Murru N, Shoukat M (2020) Therapeutic, prophylactic, and functional use of probiotics: a current perspective. Front Microbiol 11","DOI":"10.3389\/fmicb.2020.562048"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10223-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10223-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10223-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T02:10:04Z","timestamp":1727748604000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10223-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":139,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10223"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10223-5","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,29]]},"assertion":[{"value":"22 January 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing of Interest"}},{"value":"All art works were designed on Adobe Photoshop (CC 2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Graphics Program"}}]}}