{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:59:53Z","timestamp":1788965993373,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s12602-024-10233-3","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T12:02:28Z","timestamp":1708344148000},"page":"1615-1623","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide"],"prefix":"10.1007","volume":"17","author":[{"given":"Zhongjie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbin","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shegan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"issue":"7","key":"10233_CR1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.it.2016.04.007","volume":"37","author":"SW Kashem","year":"2016","unstructured":"Kashem SW, Kaplan DH (2016) Skin immunity to Candida albicans. Trends Immunol 37(7):440\u2013450. https:\/\/doi.org\/10.1016\/j.it.2016.04.007","journal-title":"Trends Immunol"},{"issue":"2","key":"10233_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4161\/viru.22913","volume":"4","author":"FL Mayer","year":"2013","unstructured":"Mayer FL, Wilson D, Hube B (2013) Candida albicans pathogenicity mechanisms. Virulence 4(2):119\u2013128. https:\/\/doi.org\/10.4161\/viru.22913","journal-title":"Virulence"},{"key":"10233_CR3","doi-asserted-by":"publisher","unstructured":"Wagener J, MacCallum DM, Brown GD et al (2017) Candida albicans chitin increases arginase-1 activity in human macrophages, with an impact on macrophage antimicrobial functions. mBio 8(1). https:\/\/doi.org\/10.1128\/mBio.01820-16","DOI":"10.1128\/mBio.01820-16"},{"key":"10233_CR4","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.2147\/IJN.S150648","volume":"13","author":"VS Radhakrishnan","year":"2018","unstructured":"Radhakrishnan VS, Reddy Mudiam MK, Kumar M et al (2018) Silver nanoparticles induced alterations in multiple cellular targets, which are critical for drug susceptibilities and pathogenicity in fungal pathogen (Candida albicans). Int J Nanomedicine 13:2647\u20132663. https:\/\/doi.org\/10.2147\/IJN.S150648","journal-title":"Int J Nanomedicine"},{"key":"10233_CR5","doi-asserted-by":"publisher","unstructured":"Gregor JB, Gutierrez-Schultz VA, Hoda S et al (2023) An expanded toolkit of drug resistance cassettes for Candida glabrata, Candida auris, and Candida albicans leads to new insights into the ergosterol pathway. mSphere e0031123. https:\/\/doi.org\/10.1128\/msphere.00311-23","DOI":"10.1128\/msphere.00311-23"},{"key":"10233_CR6","doi-asserted-by":"publisher","unstructured":"Sowers A, Wang G, Xing M et al (2023) Advances in antimicrobial peptide discovery via machine learning and delivery via nanotechnology. Microorganisms 11(5). https:\/\/doi.org\/10.3390\/microorganisms11051129","DOI":"10.3390\/microorganisms11051129"},{"issue":"1","key":"10233_CR7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1124\/pr.55.1.2","volume":"55","author":"MR Yeaman","year":"2003","unstructured":"Yeaman MR, Yount NY (2003) Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev 55(1):27\u201355. https:\/\/doi.org\/10.1124\/pr.55.1.2","journal-title":"Pharmacol Rev"},{"key":"10233_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.915368","volume":"13","author":"J Svenson","year":"2022","unstructured":"Svenson J, Molchanova N, Schroeder CI (2022) Antimicrobial peptide mimics for clinical use: Does size matter? Front Immunol 13:915368. https:\/\/doi.org\/10.3389\/fimmu.2022.915368","journal-title":"Front Immunol"},{"key":"10233_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.887763","volume":"9","author":"B Amorim-Carmo","year":"2022","unstructured":"Amorim-Carmo B, Parente AMS, Souza ES et al (2022) Antimicrobial peptide analogs from scorpions: Modifications and structure-activity. Front Mol Biosci 9:887763. https:\/\/doi.org\/10.3389\/fmolb.2022.887763","journal-title":"Front Mol Biosci"},{"key":"10233_CR10","doi-asserted-by":"publisher","unstructured":"Lourenco ALP, Rios TB, da Silva AP et al (2023) Peptide stapling applied to antimicrobial peptides. Antibiotics (Basel) 12(9). https:\/\/doi.org\/10.3390\/antibiotics12091400","DOI":"10.3390\/antibiotics12091400"},{"key":"10233_CR11","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.toxicon.2022.09.004","volume":"218","author":"S Li","year":"2022","unstructured":"Li S, Shui Y, Ma J et al (2022) Antimicrobial activity of CT-K3K7, a modified peptide by lysine substitutions from ctry2459 - a Chaerilus tryznai scorpion venom peptide. Toxicon 218:88\u201398. https:\/\/doi.org\/10.1016\/j.toxicon.2022.09.004","journal-title":"Toxicon"},{"key":"10233_CR12","unstructured":"CLSI (2019) Performance Standards for Antimicrobial Susceptibility Testing. CLSI document M100, 29th ed (ISBN 978-1-68440-032-4). https:\/\/clsi.org\/"},{"key":"10233_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.862834","volume":"13","author":"Z Li","year":"2022","unstructured":"Li Z, Jing X, Yuan Y et al (2022) In vitro and in vivo activity of Phibilin against Candida albicans. Front Microbiol 13:862834. https:\/\/doi.org\/10.3389\/fmicb.2022.862834","journal-title":"Front Microbiol"},{"key":"10233_CR14","doi-asserted-by":"publisher","unstructured":"Wang Q, Xu Y, Dong M et al (2018) Hjh-1, a broad-spectrum antimicrobial activity and low cytotoxicity antimicrobial peptide. Molecules 23(8). https:\/\/doi.org\/10.3390\/molecules23082026","DOI":"10.3390\/molecules23082026"},{"key":"10233_CR15","doi-asserted-by":"publisher","first-page":"5193","DOI":"10.1016\/j.bbagen.2013.07.016","volume":"11","author":"IK Maurya","year":"1830","unstructured":"Maurya IK, Thota CK, Sharma J et al (1830) (2013) Mechanism of action of novel synthetic dodecapeptides against Candida albicans. Biochim Biophys Acta 11:5193\u20135203. https:\/\/doi.org\/10.1016\/j.bbagen.2013.07.016","journal-title":"Biochim Biophys Acta"},{"key":"10233_CR16","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3389\/fcimb.2018.00445","volume":"8","author":"C Jia","year":"2018","unstructured":"Jia C, Zhang J, Yu L et al (2018) Antifungal activity of coumarin against Candida albicans is related to apoptosis. Front Cell Infect Microbiol 8:445. https:\/\/doi.org\/10.3389\/fcimb.2018.00445","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10233_CR17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.mycmed.2017.12.011","volume":"28","author":"LF Yang","year":"2018","unstructured":"Yang LF, Liu X, Lv LL et al (2018) Dracorhodin perchlorate inhibits biofilm formation and virulence factors of Candida albicans. J Mycol Med 28(1):36\u201344. https:\/\/doi.org\/10.1016\/j.mycmed.2017.12.011","journal-title":"J Mycol Med"},{"key":"10233_CR18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.peptides.2015.07.023","volume":"71","author":"M Scarsini","year":"2015","unstructured":"Scarsini M, Tomasinsig L, Arzese A et al (2015) Antifungal activity of cathelicidin peptides against planktonic and biofilm cultures of Candida species isolated from vaginal infections. Peptides 71:211\u2013221. https:\/\/doi.org\/10.1016\/j.peptides.2015.07.023","journal-title":"Peptides"},{"key":"10233_CR19","doi-asserted-by":"publisher","unstructured":"Garcia A, Fan YY, Vellanki S et al (2019) Nanoemulsion as an effective treatment against human-pathogenic fungi. mSphere 4(6). https:\/\/doi.org\/10.1128\/mSphere.00729-19","DOI":"10.1128\/mSphere.00729-19"},{"key":"10233_CR20","doi-asserted-by":"publisher","unstructured":"Buda De Cesare G, Cristy SA, Garsin DA et al (2020) Antimicrobial peptides: A new frontier in antifungal therapy. mBio 11(6). https:\/\/doi.org\/10.1128\/mBio.02123-20","DOI":"10.1128\/mBio.02123-20"},{"issue":"1","key":"10233_CR21","doi-asserted-by":"publisher","first-page":"10327","DOI":"10.1038\/s41598-020-67041-2","volume":"10","author":"J do Nascimento Dias","year":"2020","unstructured":"do Nascimento Dias J, de de Souza Silva C, de Araujo AR et al (2020) Mechanisms of action of antimicrobial peptides toap2 and ndbp-5.7 against Candida albicans planktonic and biofilm cells. Sci Rep 10(1):10327. https:\/\/doi.org\/10.1038\/s41598-020-67041-2","journal-title":"Sci Rep"},{"key":"10233_CR22","doi-asserted-by":"publisher","unstructured":"Jayasinghe JNC, Whang I, De Zoysa M (2023) Antifungal efficacy of antimicrobial peptide Octominin II against Candida albicans. Int J Mol Sci 24(18). https:\/\/doi.org\/10.3390\/ijms241814053","DOI":"10.3390\/ijms241814053"},{"issue":"9","key":"10233_CR23","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tibtech.2011.05.001","volume":"29","author":"LT Nguyen","year":"2011","unstructured":"Nguyen LT, Haney EF, Vogel HJ (2011) The expanding scope of antimicrobial peptide structures and their modes of action. Trends Biotechnol 29(9):464\u2013472. https:\/\/doi.org\/10.1016\/j.tibtech.2011.05.001","journal-title":"Trends Biotechnol"},{"issue":"1","key":"10233_CR24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrd3591","volume":"11","author":"CD Fjell","year":"2011","unstructured":"Fjell CD, Hiss JA, Hancock RE et al (2011) Designing antimicrobial peptides: Form follows function. Nat Rev Drug Discov 11(1):37\u201351. https:\/\/doi.org\/10.1038\/nrd3591","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"10233_CR25","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/1348-0421.12538","volume":"61","author":"A Vrablikova","year":"2017","unstructured":"Vrablikova A, Czernekova L, Cahlikova R et al (2017) Lasioglossins LLIII affect the morphogenesis of Candida albicans and reduces the duration of experimental vaginal candidiasis in mice. Microbiol Immunol 61(11):474\u2013481. https:\/\/doi.org\/10.1111\/1348-0421.12538","journal-title":"Microbiol Immunol"},{"issue":"1","key":"10233_CR26","doi-asserted-by":"publisher","first-page":"R14","DOI":"10.1016\/j.cub.2015.11.017","volume":"26","author":"LJ Zhang","year":"2016","unstructured":"Zhang LJ, Gallo RL (2016) Antimicrobial peptides. Curr Biol 26(1):R14\u2013R19. https:\/\/doi.org\/10.1016\/j.cub.2015.11.017","journal-title":"Curr Biol"},{"issue":"7","key":"10233_CR27","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1007\/s00253-015-7265-y","volume":"100","author":"L Li","year":"2016","unstructured":"Li L, Sun J, Xia S et al (2016) Mechanism of antifungal activity of antimicrobial peptide app, a cell-penetrating peptide derivative, against Candida albicans: Intracellular DNA binding and cell cycle arrest. Appl Microbiol Biotechnol 100(7):3245\u20133253. https:\/\/doi.org\/10.1007\/s00253-015-7265-y","journal-title":"Appl Microbiol Biotechnol"},{"key":"10233_CR28","doi-asserted-by":"publisher","first-page":"9912436","DOI":"10.1155\/2021\/9912436","volume":"2021","author":"GE Villalpando-Rodriguez","year":"2021","unstructured":"Villalpando-Rodriguez GE, Gibson SB (2021) Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat. Oxid Med Cell Longev 2021:9912436. https:\/\/doi.org\/10.1155\/2021\/9912436","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10233_CR29","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.celrep.2012.12.021","volume":"3","author":"P Belenky","year":"2013","unstructured":"Belenky P, Camacho D, Collins JJ (2013) Fungicidal drugs induce a common oxidative-damage cellular death pathway. Cell Rep 3(2):350\u2013358. https:\/\/doi.org\/10.1016\/j.celrep.2012.12.021","journal-title":"Cell Rep"},{"issue":"8","key":"10233_CR30","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1016\/j.biochi.2012.04.010","volume":"94","author":"JH Hwang","year":"2012","unstructured":"Hwang JH, Hwang IS, Liu QH et al (2012) (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie 94(8):1784\u20131793. https:\/\/doi.org\/10.1016\/j.biochi.2012.04.010","journal-title":"Biochimie"},{"key":"10233_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/bs.apcsb.2020.12.004","volume":"125","author":"T Atriwal","year":"2021","unstructured":"Atriwal T, Chawla M, Hussain A et al (2021) Reactive oxygen mediated apoptosis as a therapeutic approach against opportunistic Candida albicans. Adv Protein Chem Struct Biol 125:25\u201349. https:\/\/doi.org\/10.1016\/bs.apcsb.2020.12.004","journal-title":"Adv Protein Chem Struct Biol"},{"key":"10233_CR32","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.bbagen.2011.08.011","volume":"12","author":"J Cho","year":"1810","unstructured":"Cho J (1810) Lee DG (2011) The antimicrobial peptide arenicin-1 promotes generation of reactive oxygen species and induction of apoptosis. Biochim Biophys Acta 12:1246\u20131251. https:\/\/doi.org\/10.1016\/j.bbagen.2011.08.011","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10233_CR33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bbrc.2011.03.125","volume":"408","author":"B Hwang","year":"2011","unstructured":"Hwang B, Hwang JS, Lee J et al (2011) Induction of yeast apoptosis by an antimicrobial peptide. Papiliocin Biochem Biophys Res Commun 408(1):89\u201393. https:\/\/doi.org\/10.1016\/j.bbrc.2011.03.125","journal-title":"Papiliocin Biochem Biophys Res Commun"},{"issue":"1","key":"10233_CR34","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bbrc.2010.02.138","volume":"394","author":"C Park","year":"2010","unstructured":"Park C, Lee DG (2010) Melittin induces apoptotic features in Candida albicans. Biochem Biophys Res Commun 394(1):170\u2013172. https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.138","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10233_CR35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10123-022-00274-5","volume":"26","author":"H Ma","year":"2023","unstructured":"Ma H, Yang L, Tian Z et al (2023) Antimicrobial peptide AMP-17 exerts anti-Candida albicans effects through Ros-mediated apoptosis and necrosis. Int Microbiol 26(1):81\u201390. https:\/\/doi.org\/10.1007\/s10123-022-00274-5","journal-title":"Int Microbiol"},{"key":"10233_CR36","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1146\/annurev.micro.61.080706.093341","volume":"61","author":"M Whiteway","year":"2007","unstructured":"Whiteway M, Bachewich C (2007) Morphogenesis in Candida albicans. Annu Rev Microbiol 61:529\u2013553. https:\/\/doi.org\/10.1146\/annurev.micro.61.080706.093341","journal-title":"Annu Rev Microbiol"},{"issue":"6","key":"10233_CR37","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1080\/08927014.2021.1948538","volume":"37","author":"F Khan","year":"2021","unstructured":"Khan F, Bamunuarachchi NI, Tabassum N et al (2021) Suppression of hyphal formation and virulence of Candida albicans by natural and synthetic compounds. Biofouling 37(6):626\u2013655. https:\/\/doi.org\/10.1080\/08927014.2021.1948538","journal-title":"Biofouling"},{"key":"10233_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.561298","volume":"11","author":"G Abirami","year":"2020","unstructured":"Abirami G, Alexpandi R, Durgadevi R et al (2020) Inhibitory effect of morin against Candida albicans pathogenicity and virulence factor production: An in vitro and in vivo approaches. Front Microbiol 11:561298. https:\/\/doi.org\/10.3389\/fmicb.2020.561298","journal-title":"Front Microbiol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10233-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10233-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10233-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T06:41:19Z","timestamp":1746513679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10233-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10233"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10233-3","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"2 February 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the animal associated experiments were conducted following the Animal Care Ethics guidelines with protocols approved by the Animal Care and Use Committee of Henan University of Technology and Science. The mice were humanely euthanized (anesthetized by intra-peritoneal pentobarbital injection and sacrificed by cervical dislocation) at the end of the experiments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}