{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T09:44:45Z","timestamp":1784454285611,"version":"3.55.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/086"],"award-info":[{"award-number":["C24\/17\/086"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C16\/17\/010"],"award-info":[{"award-number":["C16\/17\/010"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C16\/17\/010"],"award-info":[{"award-number":["C16\/17\/010"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C24\/17\/086"],"award-info":[{"award-number":["C24\/17\/086"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G091218N"],"award-info":[{"award-number":["G091218N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G091218N"],"award-info":[{"award-number":["G091218N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12602-024-10253-z","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T08:01:51Z","timestamp":1713168111000},"page":"3041-3055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral Biofilm Composition, Dissemination to Keratinocytes, and Inflammatory Attenuation Depend on Probiotic and Synbiotic Strain Specificity"],"prefix":"10.1007","volume":"17","author":[{"given":"Wannes","family":"Van Holm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiera","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalina","family":"Lauwens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehraveh","family":"Saghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Axelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve K\u00fcbra","family":"Aktan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Braem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Simoens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Vanbrabant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Proost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Van Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Bernaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Teughels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"10253_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nri.2017.7","volume":"17","author":"M Levy","year":"2017","unstructured":"Levy M, Kolodziejczyk AA, Thaiss CA, Elinav E (2017) Dysbiosis and the immune system. Nat Rev Immunol 17:219\u2013232. https:\/\/doi.org\/10.1038\/nri.2017.7","journal-title":"Nat Rev Immunol"},{"key":"10253_CR2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nrmicro2337","volume":"8","author":"RP Darveau","year":"2010","unstructured":"Darveau RP (2010) Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol 8:481\u2013490. https:\/\/doi.org\/10.1038\/nrmicro2337","journal-title":"Nat Rev Microbiol"},{"key":"10253_CR3","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill C, Guarner F, Reid G et al (2014) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11:506\u2013514. https:\/\/doi.org\/10.1038\/nrgastro.2014.66","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10253_CR4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","volume":"17","author":"KS Swanson","year":"2020","unstructured":"Swanson KS, Gibson GR, Hutkins R et al (2020) The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol 17:687\u2013701. https:\/\/doi.org\/10.1038\/s41575-020-0344-2","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10253_CR5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","volume":"14","author":"GR Gibson","year":"2017","unstructured":"Gibson GR, Hutkins R, Sanders ME et al (2017) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14:491\u2013502. https:\/\/doi.org\/10.1038\/nrgastro.2017.75","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"63","key":"10253_CR6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/prd.12034.Natural","volume":"2000","author":"M Freire","year":"2013","unstructured":"Freire M, Van Dyke TE (2013) Natural resolution of inflammation Periodontol 2000(63):149\u2013164. https:\/\/doi.org\/10.1111\/prd.12034.Natural","journal-title":"Natural resolution of inflammation Periodontol"},{"key":"10253_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","volume":"35","author":"G Hajishengallis","year":"2014","unstructured":"Hajishengallis G (2014) Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol 35:3\u201311. https:\/\/doi.org\/10.1016\/j.it.2013.09.001","journal-title":"Trends Immunol"},{"key":"10253_CR8","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","volume":"16","author":"RJ Lamont","year":"2018","unstructured":"Lamont RJ, Koo H, Hajishengallis G (2018) The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol 16:745\u2013759. https:\/\/doi.org\/10.1038\/s41579-018-0089-x","journal-title":"Nat Rev Microbiol"},{"key":"10253_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-16","author":"SC Ligaarden","year":"2010","unstructured":"Ligaarden SC, Axelsson L, Naterstad K et al (2010) A candidate probiotic with unfavourable effects in subjects with irritable bowel syndrome: a randomised controlled trial. BMC Gastroenterol. https:\/\/doi.org\/10.1186\/1471-230X-10-16","journal-title":"BMC Gastroenterol"},{"key":"10253_CR10","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.3748\/wjg.v18.i30.4012","volume":"18","author":"P Ducrott\u00e9","year":"2012","unstructured":"Ducrott\u00e9 P, Sawant P, Jayanthi V (2012) Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 18:4012\u20134018. https:\/\/doi.org\/10.3748\/wjg.v18.i30.4012","journal-title":"World J Gastroenterol"},{"key":"10253_CR11","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fmed.2018.00124","volume":"5","author":"LV McFarland","year":"2018","unstructured":"McFarland LV, Evans CT, Goldstein EJC (2018) Strain-specificity and disease-specificity of probiotic efficacy: a systematic review and meta-analysis. Front Med 5:124. https:\/\/doi.org\/10.3389\/fmed.2018.00124","journal-title":"Front Med"},{"key":"10253_CR12","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41564-020-0721-1","volume":"5","author":"P Veiga","year":"2020","unstructured":"Veiga P, Suez J, Derrien M, Elinav E (2020) Moving from probiotics to precision probiotics. Nat Microbiol 5:878\u2013880. https:\/\/doi.org\/10.1038\/s41564-020-0721-1","journal-title":"Nat Microbiol"},{"key":"10253_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41415-021-3624-5","volume":"23","author":"N Canut-Delgado","year":"2021","unstructured":"Canut-Delgado N, Giovannoni ML, Chimenos-k\u00fcstner E (2021) Are probiotics a possible treatment of periodontitis? Probiotics against periodontal disease: a systematic review. Br Dent J 23:1\u20137. https:\/\/doi.org\/10.1038\/s41415-021-3624-5","journal-title":"Br Dent J"},{"key":"10253_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/prd.12382","volume":"87","author":"T Nguyen","year":"2000","unstructured":"Nguyen T, Brody H, Radaic A (2000) Kapila Y (2021) Probiotics for periodontal health\u2014current molecular findings. Periodontol 87:254\u2013267. https:\/\/doi.org\/10.1111\/prd.12382","journal-title":"Periodontol"},{"key":"10253_CR15","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1111\/jcpe.12155","volume":"40","author":"W Teughels","year":"2013","unstructured":"Teughels W, Durukan A, Ozcelik O et al (2013) Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 40:1025\u20131035. https:\/\/doi.org\/10.1111\/jcpe.12155","journal-title":"J Clin Periodontol"},{"key":"10253_CR16","first-page":"197","volume":"31","author":"S Sabatini","year":"2017","unstructured":"Sabatini S, Lauritano D, Candotto V et al (2017) Oral probiotics in the management of gingivitis in diabetic patients: a double blinded randomized controlled study. J Biol Regul Homeost Agents 31:197\u2013202","journal-title":"J Biol Regul Homeost Agents"},{"key":"10253_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.682656","volume":"12","author":"T Sang-Ngoen","year":"2021","unstructured":"Sang-Ngoen T, Czumbel LM, Sadaeng W et al (2021) Orally administered probiotics decrease Aggregatibacter actinomycetemcomitans but not other periodontal pathogenic bacteria counts in the oral cavity: a systematic review and meta-analysis. Front Pharmacol 12:682656. https:\/\/doi.org\/10.3389\/fphar.2021.682656","journal-title":"Front Pharmacol"},{"key":"10253_CR18","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3109\/00016357.2012.734406","volume":"71","author":"H Hallstr\u00f6m","year":"2013","unstructured":"Hallstr\u00f6m H, Lindgren S, Yucel-Lindberg T et al (2013) Effect of probiotic lozenges on inflammatory reactions and oral biofilm during experimental gingivitis. Acta Odontol Scand 71:828\u2013833. https:\/\/doi.org\/10.3109\/00016357.2012.734406","journal-title":"Acta Odontol Scand"},{"key":"10253_CR19","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1111\/jcpe.13191","volume":"46","author":"G Pelekos","year":"2019","unstructured":"Pelekos G, Ho SN, Acharya A et al (2019) A double-blind, paralleled-arm, placebo-controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care. J Clin Periodontol 46:1217\u20131227. https:\/\/doi.org\/10.1111\/jcpe.13191","journal-title":"J Clin Periodontol"},{"key":"10253_CR20","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1111\/jcpe.12464","volume":"42","author":"I Laleman","year":"2015","unstructured":"Laleman I, Yilmaz E, Ozcelik O et al (2015) The effect of a streptococci containing probiotic in periodontal therapy: a randomized controlled trial. J Clin Periodontol 42:1032\u20131041. https:\/\/doi.org\/10.1111\/jcpe.12464","journal-title":"J Clin Periodontol"},{"key":"10253_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41522-023-00370-y","volume":"9","author":"W Van Holm","year":"2023","unstructured":"Van Holm W, Carvalho R, Delanghe L et al (2023) Antimicrobial potential of known and novel probiotics on in vitro periodontitis biofilms. npj Biofilms Microbiomes 9:3. https:\/\/doi.org\/10.1038\/s41522-023-00370-y","journal-title":"npj Biofilms Microbiomes"},{"key":"10253_CR22","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/omi.12386","volume":"37","author":"W Van Holm","year":"2022","unstructured":"Van Holm W, Verspecht T, Carvalho R et al (2022) Glycerol strengthens probiotic effect of Limosilactobacillus reuteri in oral biofilms: a synergistic synbiotic approach. Mol Oral Microbiol 37:266\u2013275. https:\/\/doi.org\/10.1111\/omi.12386","journal-title":"Mol Oral Microbiol"},{"key":"10253_CR23","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1177\/0022034509347296","volume":"88","author":"I Sliepen","year":"2009","unstructured":"Sliepen I, Van Damme J, Van Esshe M et al (2009) Microbial interactions influence inflammatory host cell responses. J Dent Res 88:1026\u20131030. https:\/\/doi.org\/10.1177\/0022034509347296","journal-title":"J Dent Res"},{"key":"10253_CR24","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1002\/JPER.17-0437","volume":"89","author":"V Slomka","year":"2018","unstructured":"Slomka V, Herrero ER, Daep C et al (2018) Oral prebiotics and the influence of environmental conditions in vitro. J Periodontol 89:708\u2013717. https:\/\/doi.org\/10.1002\/JPER.17-0437","journal-title":"J Periodontol"},{"key":"10253_CR25","doi-asserted-by":"crossref","unstructured":"\u00c0lvarez G, Gonz\u00e1lez M, Isabal S, et al (2013) Method to quantify live and dead cells in multi-species oral biofilm by real-time PCR with propidium monoazide. AMB Express 3","DOI":"10.1186\/2191-0855-3-1"},{"key":"10253_CR26","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1111\/j.1574-6941.2010.00974.x","volume":"74","author":"R De Weirdt","year":"2010","unstructured":"De Weirdt R, Possemiers S, Vermeulen G et al (2010) Human faecal microbiota display variable patterns of glycerol metabolism. FEMS Microbiol Ecol 74:601\u2013611. https:\/\/doi.org\/10.1111\/j.1574-6941.2010.00974.x","journal-title":"FEMS Microbiol Ecol"},{"key":"10253_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0168-1605(00)00191-4","volume":"55","author":"N Sauvageot","year":"2000","unstructured":"Sauvageot N, Gouffi K, Laplace JM, Auffray Y (2000) Glycerol metabolism in Lactobacillus collinoides: production of 3-hydroxypropionaldehyde, a precursor of acrolein. Int J Food Microbiol 55:167\u2013170. https:\/\/doi.org\/10.1016\/S0168-1605(00)00191-4","journal-title":"Int J Food Microbiol"},{"key":"10253_CR28","unstructured":"Bio-Rad (1995) Bulletin 1928 Rev B: Overview and Strategies for Bio-Organic Molecule Purification. 81"},{"key":"10253_CR29","doi-asserted-by":"publisher","first-page":"02653","DOI":"10.1128\/AEM.02653-20","volume":"87","author":"W Van Holm","year":"2021","unstructured":"Van Holm W, Ghesqui\u00e8re J, Boon N et al (2021) A viability quantitative PCR dilemma: are longer amplicons better? Appl Environ Microbiol 87:02653\u201302720. https:\/\/doi.org\/10.1128\/AEM.02653-20","journal-title":"Appl Environ Microbiol"},{"key":"10253_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340022","volume":"1218","author":"MK Aktan","year":"2022","unstructured":"Aktan MK, Van Der GM, Hendrix H et al (2022) Anti-infective DNase I coatings on polydopamine functionalized titanium surfaces by alternating current electrophoretic deposition. Anal Chim Acta 1218:340022. https:\/\/doi.org\/10.1016\/j.aca.2022.340022","journal-title":"Anal Chim Acta"},{"key":"10253_CR31","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1902\/jop.2012.120422.Blocking","volume":"84","author":"E Berker","year":"2013","unstructured":"Berker E, Kantarci A, Hasturk H, Van Dyke TE (2013) Blocking pro-inflammatory cytokine release modulates peripheral blood mononuclear cell response to Porphyromonas gingivalis. J Periodontol 84:1337\u20131345. https:\/\/doi.org\/10.1902\/jop.2012.120422.Blocking","journal-title":"J Periodontol"},{"key":"10253_CR32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/jcpe.13232","volume":"47","author":"N Donos","year":"2019","unstructured":"Donos N, Calciolari E, Brusselaers N et al (2019) The adjunctive use of host modulators in non-surgical periodontal therapy. A systematic review of randomized, placebo-controlled clinical studies. J Clin Periodontol 47:199\u2013238. https:\/\/doi.org\/10.1111\/jcpe.13232","journal-title":"J Clin Periodontol"},{"key":"10253_CR33","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1099\/mic.0.035642-0","volume":"156","author":"L Schaefer","year":"2010","unstructured":"Schaefer L, Auchtung TA, Hermans KE et al (2010) The antimicrobial compound reuterin (3- hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups. Microbiology 156:1589\u20131599. https:\/\/doi.org\/10.1099\/mic.0.035642-0","journal-title":"Microbiology"},{"key":"10253_CR34","doi-asserted-by":"publisher","first-page":"36246","DOI":"10.1038\/srep36246","volume":"6","author":"C Engels","year":"2016","unstructured":"Engels C, Schwab C, Zhang J et al (2016) Acrolein contributes strongly to antimicrobial and heterocyclic amine transformation activities of reuterin. Sci Rep 6:36246. https:\/\/doi.org\/10.1038\/srep36246","journal-title":"Sci Rep"},{"key":"10253_CR35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/1471-2180-7-101","volume":"7","author":"V Cleusix","year":"2007","unstructured":"Cleusix V, Lacroix C, Vollenweider S et al (2007) Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria. BMC Microbiol 7:101. https:\/\/doi.org\/10.1186\/1471-2180-7-101","journal-title":"BMC Microbiol"},{"key":"10253_CR36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00253-005-1895-4","volume":"68","author":"Y Doleyres","year":"2005","unstructured":"Doleyres Y, Beck P, Vollenweider S, Lacroix C (2005) Production of 3-hydroxypropionaldehyde using a two-step process with Lactobacillus reuteri. Appl Microbiol Biotechnol 68:467\u2013474. https:\/\/doi.org\/10.1007\/s00253-005-1895-4","journal-title":"Appl Microbiol Biotechnol"},{"key":"10253_CR37","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3389\/fchem.2019.00731","volume":"7","author":"H Nakagawa","year":"2019","unstructured":"Nakagawa H, Oyama T (2019) Molecular basis of water activity in glycerol \u2013 water mixtures. Front Chem 7:731. https:\/\/doi.org\/10.3389\/fchem.2019.00731","journal-title":"Front Chem"},{"key":"10253_CR38","first-page":"345","volume":"26","author":"LR Beuchat","year":"1981","unstructured":"Beuchat LR (1981) Microbial stability as affected by water activity [Bacteria, fungi, spoilage]. Cereal Foods World 26:345\u2013349","journal-title":"Cereal Foods World"},{"key":"10253_CR39","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.crfs.2021.11.013","volume":"4","author":"FJ Rodrigues","year":"2021","unstructured":"Rodrigues FJ, Cedran MF, Bicas JL, Sato HH (2021) Reuterin production in alginate-based filmogenic solutions. Curr Res Food Sci 4:926\u2013931. https:\/\/doi.org\/10.1016\/j.crfs.2021.11.013","journal-title":"Curr Res Food Sci"},{"key":"10253_CR40","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1128\/aem.56.4.1195-1197.1990","volume":"56","author":"WJ Dobrogosz","year":"1990","unstructured":"Dobrogosz WJ (1990) Purification and characterization of glycerol dehydratase from Lactobacillus reuteri. Appl Environ Microbiol 56:1195\u20131197","journal-title":"Appl Environ Microbiol"},{"key":"10253_CR41","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s00253-003-1536-8","volume":"64","author":"MG G\u00e4nzle","year":"2004","unstructured":"G\u00e4nzle MG (2004) Reutericyclin: biological activity, mode of action, and potential applications. Appl Microbiol Biotechnol 64:326\u2013332. https:\/\/doi.org\/10.1007\/s00253-003-1536-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"10253_CR42","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nrmicro1273","volume":"3","author":"PD Cotter","year":"2005","unstructured":"Cotter PD, Hill C, Ross RP (2005) Bacteriocins: developing innate immunity for food. Nat Rev Microbiol 3:777\u2013788. https:\/\/doi.org\/10.1038\/nrmicro1273","journal-title":"Nat Rev Microbiol"},{"key":"10253_CR43","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3389\/fmicb.2014.00241","volume":"5","author":"SC Yang","year":"2014","unstructured":"Yang SC, Lin CH, Sung CT, Fang JY (2014) Antibacterial activities of bacteriocins: application in foods and pharmaceuticals. Front Microbiol 5:241. https:\/\/doi.org\/10.3389\/fmicb.2014.00241","journal-title":"Front Microbiol"},{"key":"10253_CR44","doi-asserted-by":"publisher","first-page":"1274582","DOI":"10.1080\/20002297.2016.1274582","volume":"9","author":"MR J\u00f8rgensen","year":"2017","unstructured":"J\u00f8rgensen MR, Kragelund C, Jensen P\u00d8 (2017) Probiotic Lactobacillus reuteri has antifungal effects on oral Candida species in vitro. J Oral Microbiol 9:1274582. https:\/\/doi.org\/10.1080\/20002297.2016.1274582","journal-title":"J Oral Microbiol"},{"key":"10253_CR45","first-page":"01271","volume":"85","author":"LP Cornacchione","year":"2019","unstructured":"Cornacchione LP, Klein BA, Duncan MJ, Hu LT (2019) Interspecies inhibition of Porphyromonas gingivalis by yogurt-derived Lactobacillus delbrueckii requires active pyruvate oxidase. Food Microbiol 85:01271\u201301319","journal-title":"Food Microbiol"},{"key":"10253_CR46","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1128\/AEM.66.5.2001-2005.2000","volume":"66","author":"M Saarela","year":"2000","unstructured":"Saarela M (2000) Lactic acid permeabilizes gram-negative bacteria by disrupting the outer membrane. Appl Environ Microbiol 66:2001\u20132005","journal-title":"Appl Environ Microbiol"},{"key":"10253_CR47","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.3389\/fmicb.2017.01205","volume":"8","author":"H Mathur","year":"2017","unstructured":"Mathur H, Field D, Rea MC et al (2017) Bacteriocin-antimicrobial synergy: a medical and food perspective. Front Microbiol 8:1205. https:\/\/doi.org\/10.3389\/fmicb.2017.01205","journal-title":"Front Microbiol"},{"key":"10253_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fdmed.2021.708666","volume":"2","author":"U Schlagenhauf","year":"2021","unstructured":"Schlagenhauf U, Jockel-schneider Y (2021) Probiotics in the management of gingivitis and periodontitis. A review Front Dent Med 2:708666. https:\/\/doi.org\/10.3389\/fdmed.2021.708666","journal-title":"A review Front Dent Med"},{"key":"10253_CR49","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12866-019-1403-0","volume":"19","author":"PM Ryan","year":"2019","unstructured":"Ryan PM, Stolte EH, London LEE et al (2019) Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe. BMC Microbiol 19:33. https:\/\/doi.org\/10.1186\/s12866-019-1403-0","journal-title":"BMC Microbiol"},{"key":"10253_CR50","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.archoralbio.2010.09.019","volume":"56","author":"LC Pham","year":"2011","unstructured":"Pham LC, Hoogenkamp MA, Exterkate RAM et al (2011) Effects of Lactobacillus rhamnosus GG on saliva-derived microcosms. Arch Oral Biol 56:136\u2013147. https:\/\/doi.org\/10.1016\/j.archoralbio.2010.09.019","journal-title":"Arch Oral Biol"},{"key":"10253_CR51","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1159\/000047484","volume":"35","author":"L N\u00e4se","year":"2001","unstructured":"N\u00e4se L, Hatakka K, Savilahti E et al (2001) Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res 35:412\u2013420. https:\/\/doi.org\/10.1159\/000047484","journal-title":"Caries Res"},{"key":"10253_CR52","doi-asserted-by":"publisher","first-page":"14147","DOI":"10.1111\/jfpp.14147","volume":"43","author":"S Piwat","year":"2019","unstructured":"Piwat S, Pahumunto N, Mapaisansin C, Teanpaisan R (2019) Effect of probiotic delivery vehicles for probiotic Lactobacillus rhamnosus SD11 in caries prevention: a clinical study. J Food Process Preserv 43:14147. https:\/\/doi.org\/10.1111\/jfpp.14147","journal-title":"J Food Process Preserv"},{"key":"10253_CR53","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000355907","volume":"48","author":"F Schwendicke","year":"2014","unstructured":"Schwendicke F, D\u00f6rfer C, Kneist S, Paris HMS (2014) Cariogenic effects of probiotic Lactobacillus rhamnosus GG in a dental biofilm model. Caries Res 48:186\u2013192. https:\/\/doi.org\/10.1159\/000355907","journal-title":"Caries Res"},{"key":"10253_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/froh.2021.774115","volume":"2","author":"P Zhou","year":"2021","unstructured":"Zhou P, Manoil D, Belibasakis GN, Kotsakis GA (2021) Veillonellae: beyond bridging species in oral biofilm ecology. Front Oral Heal 2:1\u201311. https:\/\/doi.org\/10.3389\/froh.2021.774115","journal-title":"Front Oral Heal"},{"key":"10253_CR55","doi-asserted-by":"publisher","first-page":"4632","DOI":"10.1128\/JB.00276-08","volume":"190","author":"J Kreth","year":"2008","unstructured":"Kreth J, Zhang Y, Herzberg MC (2008) Streptococcal antagonism in oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans. J Bacteriol 190:4632\u20134640. https:\/\/doi.org\/10.1128\/JB.00276-08","journal-title":"J Bacteriol"},{"key":"10253_CR56","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1111\/j.1365-2958.2010.07420.x","volume":"78","author":"A Chawla","year":"2010","unstructured":"Chawla A, Hirano T, Bainbridge BW et al (2010) Community signalling between Streptococcus gordonii and Porphyromonas gingivalis is controlled by the transcriptional regulator CdhR. Mol Microbiol 78:1510\u20131522. https:\/\/doi.org\/10.1111\/j.1365-2958.2010.07420.x","journal-title":"Mol Microbiol"},{"key":"10253_CR57","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785.Periodontitis","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis G (2015) Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 15:30\u201344. https:\/\/doi.org\/10.1038\/nri3785.Periodontitis","journal-title":"Nat Rev Immunol"},{"key":"10253_CR58","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3390\/pathogens10101280","volume":"10","author":"D Celik","year":"2021","unstructured":"Celik D, Kantarci A (2021) Vascular changes and hypoxia in periodontal disease as a link to systemic complications. Pathogens 10:1280. https:\/\/doi.org\/10.3390\/pathogens10101280","journal-title":"Pathogens"},{"key":"10253_CR59","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/omi.12330","volume":"36","author":"KH Ishikawa","year":"2020","unstructured":"Ishikawa KH, Bueno MR, Kawamoto D et al (2020) Lactobacilli postbiotics reduce biofilm formation and alter transcription of virulence genes of Aggregatibacter actinomycetemcomitans. Mol Oral Microbiol 36:92\u2013102. https:\/\/doi.org\/10.1111\/omi.12330","journal-title":"Mol Oral Microbiol"},{"key":"10253_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.578386","volume":"12","author":"F Cristofori","year":"2021","unstructured":"Cristofori F, Dargenio VN, Dargenio C et al (2021) Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body. Front Immunol 12:578386. https:\/\/doi.org\/10.3389\/fimmu.2021.578386","journal-title":"Front Immunol"},{"key":"10253_CR61","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1002\/ibd.20448","volume":"14","author":"YP Lin","year":"2008","unstructured":"Lin YP, Thibodeaux CH, Pe\u00f1a JA et al (2008) Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun. Inflamm Bowel Dis 14:1068\u20131083. https:\/\/doi.org\/10.1002\/ibd.20448","journal-title":"Inflamm Bowel Dis"},{"key":"10253_CR62","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.3390\/ijms22115921","volume":"22","author":"G Kim","year":"2021","unstructured":"Kim G, Choi KH, Kim H, Chung DK (2021) Alleviation of LPS-induced inflammation and septic shock by Lactiplantibacillus plantarum K8 lysates. Int J Mol Sci 22:5921. https:\/\/doi.org\/10.3390\/ijms22115921","journal-title":"Int J Mol Sci"},{"key":"10253_CR63","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2180-9-35","volume":"9","author":"SE Jones","year":"2009","unstructured":"Jones SE, Versalovic J (2009) Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors. BMC Microbiol 9:35. https:\/\/doi.org\/10.1186\/1471-2180-9-35","journal-title":"BMC Microbiol"},{"key":"10253_CR64","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1053\/j.gastro.2004.09.001","volume":"127","author":"EO Petrof","year":"2004","unstructured":"Petrof EO, Kojima K, Ropeleski MJ et al (2004) Probiotics inhibit nuclear factor-\u03baB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology 127:1474\u20131487. https:\/\/doi.org\/10.1053\/j.gastro.2004.09.001","journal-title":"Gastroenterology"},{"key":"10253_CR65","doi-asserted-by":"publisher","first-page":"14719","DOI":"10.14814\/phy2.14719","volume":"9","author":"MA Engevik","year":"2021","unstructured":"Engevik MA, Ruan W, Esparza M et al (2021) Immunomodulation of dendritic cells by Lactobacillus reuteri surface components and metabolites. Physiol Rep 9:14719. https:\/\/doi.org\/10.14814\/phy2.14719","journal-title":"Physiol Rep"},{"key":"10253_CR66","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.3168\/jds.2017-13868","volume":"101","author":"R Kaji","year":"2018","unstructured":"Kaji R, Kiyoshima-Shibata J, Tsujibe S et al (2018) Short communication: Probiotic induction of interleukin-10 and interleukin-12 production by macrophages is modulated by co-stimulation with microbial components. J Dairy Sci 101:2838\u20132841. https:\/\/doi.org\/10.3168\/jds.2017-13868","journal-title":"J Dairy Sci"},{"key":"10253_CR67","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s12263-013-0347-5","volume":"8","author":"V Aparna Sudhakaran","year":"2013","unstructured":"Aparna Sudhakaran V, Panwar H, Chauhan R et al (2013) Modulation of anti-inflammatory response in lipopolysaccharide stimulated human THP-1 cell line and mouse model at gene expression level with indigenous putative probiotic lactobacilli. Genes Nutr 8:637\u2013648. https:\/\/doi.org\/10.1007\/s12263-013-0347-5","journal-title":"Genes Nutr"},{"key":"10253_CR68","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.crfs.2020.02.002","volume":"3","author":"MP Jeffrey","year":"2020","unstructured":"Jeffrey MP, Jones Taggart H, Strap JL et al (2020) Milk fermented with Lactobacillus rhamnosus R0011 induces a regulatory cytokine profile in LPS-challenged U937 and THP-1 macrophages. Curr Res Food Sci 3:51\u201358. https:\/\/doi.org\/10.1016\/j.crfs.2020.02.002","journal-title":"Curr Res Food Sci"},{"key":"10253_CR69","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/thx.51.2.143","volume":"51","author":"L Armstrong","year":"1996","unstructured":"Armstrong L, Jordan N, Millar A (1996) Interleukin 10 (IL-10) regulation of tumour necrosis factor a (TNF-a) from human alveolar macrophages and peripheral blood monocytes. Thorax 51:143\u2013149","journal-title":"Thorax"},{"key":"10253_CR70","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1756308","author":"S De Marco","year":"2018","unstructured":"De Marco S, Sichetti M, Muradyan D et al (2018) Probiotic cell-free supernatants and antioxidant activity on human gut epithelial cells and macrophages stimulated with LPS. Evidence-Based Complement Altern Med. https:\/\/doi.org\/10.1155\/2018\/1756308","journal-title":"Evidence-Based Complement Altern Med"},{"key":"10253_CR71","doi-asserted-by":"publisher","first-page":"1032202","DOI":"10.3389\/fmicb.2022.1032202","volume":"13","author":"LE Lundberg","year":"2022","unstructured":"Lundberg LE, Forsberg MM, Ahl D et al (2022) Extracellular membrane vesicles from Limosilactobacillus reuteri strengthen the intestinal epithelial integrity, modulate cytokine responses and antagonize activation of TRPV1. Front Microbiol 13:1032202. https:\/\/doi.org\/10.3389\/fmicb.2022.1032202","journal-title":"Front Microbiol"},{"key":"10253_CR72","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1002\/cti2.1213","volume":"9","author":"L Jia","year":"2020","unstructured":"Jia L, Wu R, Han N et al (2020) Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17\/Treg balance in colitis via TLR4 and TLR2. Clin Transl Immunol 9:1213. https:\/\/doi.org\/10.1002\/cti2.1213","journal-title":"Clin Transl Immunol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10253-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10253-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10253-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:02:37Z","timestamp":1760659357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10253-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10253"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10253-z","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]},"assertion":[{"value":"1 April 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"JA is an employee of BioGaia AB. Part of materials cost was covered by BioGaia AB. WT has lectured for BioGaia AB. The KU Leuven has received a research grant and has conducted several clinical studies for BioGaia AB. The other authors report no conflicts of interest related to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}