{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:06:27Z","timestamp":1792101987956,"version":"4.4.0"},"reference-count":151,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","award":["2021R1A6C101A416"],"award-info":[{"award-number":["2021R1A6C101A416"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s12602-024-10262-y","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T09:01:31Z","timestamp":1713776491000},"page":"1744-1761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-3282","authenticated-orcid":false,"given":"Vineet","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6826-6719","authenticated-orcid":false,"given":"Kanika","family":"Mahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6683-0991","authenticated-orcid":false,"given":"DaRyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-9787","authenticated-orcid":false,"given":"Jae-Ho","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"10262_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2021.100085","volume":"3","author":"J Bulsara","year":"2021","unstructured":"Bulsara J, Patel P, Soni A, Acharya S (2021) A review: brief insight into polycystic ovarian syndrome. Endocrine and Metabolic Science 3:100085. https:\/\/doi.org\/10.1016\/j.endmts.2021.100085","journal-title":"Endocrine and Metabolic Science"},{"issue":"2","key":"10262_CR2","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","volume":"91","author":"R Azziz","year":"2009","unstructured":"Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE (2009) The androgen excess and PCOS society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 91(2):456\u2013488. https:\/\/doi.org\/10.1016\/j.fertnstert.2008.06.035","journal-title":"Fertil Steril"},{"issue":"9","key":"10262_CR3","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1210\/jcem.85.9.6814","volume":"85","author":"L Ib\u00e1\u00f1ez","year":"2000","unstructured":"Ib\u00e1\u00f1ez L, Potau N, Marcos MV, de Zegher F (2000) Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide. J Clin Endocrinol Metab 85(9):3251\u20133255. https:\/\/doi.org\/10.1210\/jcem.85.9.6814","journal-title":"J Clin Endocrinol Metab"},{"issue":"39","key":"10262_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000012608","volume":"97","author":"DC Ding","year":"2018","unstructured":"Ding DC, Chen W, Wang JH, Lin SZ (2018) Association between polycystic ovarian syndrome and endometrial, ovarian, and breast cancer: a population-based cohort study in Taiwan. Medicine 97(39):e12608. https:\/\/doi.org\/10.1097\/md.0000000000012608","journal-title":"Medicine"},{"issue":"11","key":"10262_CR5","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1093\/humrep\/dey292","volume":"33","author":"C Zhang","year":"2018","unstructured":"Zhang C, Ma J, Wang W, Sun Y, Sun K (2018) Lysyl oxidase blockade ameliorates anovulation in polycystic ovary syndrome. Human reproduction (Oxford, England) 33(11):2096\u20132106. https:\/\/doi.org\/10.1093\/humrep\/dey292","journal-title":"Human reproduction (Oxford, England)"},{"issue":"7","key":"10262_CR6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.5694\/mja18.00635","volume":"209","author":"RJ Norman","year":"2018","unstructured":"Norman RJ, Teede HJ (2018) A new evidence-based guideline for assessment and management of polycystic ovary syndrome. Med J Aust 209(7):299\u2013300. https:\/\/doi.org\/10.5694\/mja18.00635","journal-title":"Med J Aust"},{"issue":"4","key":"10262_CR7","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/S1665-2681(19)31616-3","volume":"9","author":"Y Gutierrez-Grobe","year":"2010","unstructured":"Gutierrez-Grobe Y, Ponciano-Rodr\u00edguez G, Ramos MH, Uribe M, M\u00e9ndez-S\u00e1nchez N (2010) Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens. J Hepatol 9(4):402\u2013409. https:\/\/doi.org\/10.1016\/S1665-2681(19)31616-3","journal-title":"J Hepatol"},{"issue":"2","key":"10262_CR8","doi-asserted-by":"publisher","first-page":"122","DOI":"10.23736\/s0391-1977.16.02564-5","volume":"42","author":"E Makri","year":"2017","unstructured":"Makri E, Tziomalos K (2017) Prevalence, etiology and management of non-alcoholic fatty liver disease in patients with polycystic ovary syndrome. Minerva Endocrinol 42(2):122\u2013131. https:\/\/doi.org\/10.23736\/s0391-1977.16.02564-5","journal-title":"Minerva Endocrinol"},{"key":"10262_CR9","unstructured":"Rasquin L I, Anastasopoulou C, Mayrin J V (2022) Polycystic ovarian disease, in StatPearls [Internet]. StatPearls Publishing"},{"key":"10262_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cca.2019.09.010","volume":"499","author":"J-l Zhu","year":"2019","unstructured":"Zhu J-l, Chen Z, Feng W-j, Long S-l, Mo Z-C (2019) Sex hormone-binding globulin and polycystic ovary syndrome. Clin Chim Acta 499:142\u2013148. https:\/\/doi.org\/10.1016\/j.cca.2019.09.010","journal-title":"Clin Chim Acta"},{"issue":"1","key":"10262_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tem.2018.11.001","volume":"30","author":"VG Thackray","year":"2019","unstructured":"Thackray VG (2019) Sex, microbes, and polycystic ovary syndrome. Trends Endocrinol Metab 30(1):54\u201365. https:\/\/doi.org\/10.1016\/j.tem.2018.11.001","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"10262_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168390","volume":"12","author":"L Lindheim","year":"2017","unstructured":"Lindheim L, Bashir M, M\u00fcnzker J, Trummer C, Zachhuber V, Leber B, Horvath A, Pieber TR, Gorkiewicz G, Stadlbauer V, Obermayer-Pietsch B (2017) Alterations in gut microbiome composition and barrier function are associated with reproductive and metabolic defects in women with polycystic ovary syndrome (PCOS): a pilot study. PLoS ONE 12(1):e0168390. https:\/\/doi.org\/10.1371\/journal.pone.0168390","journal-title":"PLoS ONE"},{"key":"10262_CR13","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3389\/fmicb.2017.00324","volume":"8","author":"R Liu","year":"2017","unstructured":"Liu R, Zhang C, Shi Y, Zhang F, Li L, Wang X, Ling Y, Fu H, Dong W, Shen J, Reeves A, Greenberg AS, Zhao L, Peng Y, Ding X (2017) Dysbiosis of gut microbiota associated with clinical parameters in polycystic ovary syndrome. Front Microbiol 8:324. https:\/\/doi.org\/10.3389\/fmicb.2017.00324","journal-title":"Front Microbiol"},{"issue":"4","key":"10262_CR14","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1210\/jc.2017-02153","volume":"103","author":"PJ Torres","year":"2018","unstructured":"Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, Thackray VG (2018) Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism. J Clin Endocrinol Metab 103(4):1502\u20131511. https:\/\/doi.org\/10.1210\/jc.2017-02153","journal-title":"J Clin Endocrinol Metab"},{"issue":"29","key":"10262_CR15","doi-asserted-by":"publisher","first-page":"9961","DOI":"10.1080\/10408398.2022.2076651","volume":"63","author":"V Singh","year":"2023","unstructured":"Singh V, Park Y-J, Lee G, Unno T, Shin J-H (2023) Dietary regulations for microbiota dysbiosis among post-menopausal women with type 2 diabetes. Crit Rev Food Sci Nutr 63(29):9961\u20139976. https:\/\/doi.org\/10.1080\/10408398.2022.2076651","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10262_CR16","doi-asserted-by":"publisher","first-page":"1103836","DOI":"10.3389\/fmicb.2022.1103836","volume":"13","author":"V Singh","year":"2023","unstructured":"Singh V, Lee G, Son H, Koh H, Kim ES, Unno T, Shin J-H (2023) Butyrate producers, \u201cThe Sentinel of Gut\u201d: their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics. Front Microbiol 13:1103836. https:\/\/doi.org\/10.3389\/fmicb.2022.1103836","journal-title":"Front Microbiol"},{"key":"10262_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105445","volume":"194","author":"N Salva-Pastor","year":"2019","unstructured":"Salva-Pastor N, Ch\u00e1vez-Tapia NC, Uribe M, Nu\u00f1o-L\u00e1mbarri N (2019) Understanding the association of polycystic ovary syndrome and non-alcoholic fatty liver disease. J Steroid Biochem Mol Biol 194:105445. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105445","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"10262_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12020-019-02085-7","volume":"67","author":"SA Paschou","year":"2020","unstructured":"Paschou SA, Polyzos SA, Anagnostis P, Goulis DG, Kanaka-Gantenbein C, Lambrinoudaki I, Georgopoulos NA, Vryonidou A (2020) Nonalcoholic fatty liver disease in women with polycystic ovary syndrome. Endocrine 67(1):1\u20138. https:\/\/doi.org\/10.1007\/s12020-019-02085-7","journal-title":"Endocrine"},{"issue":"3","key":"10262_CR19","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/hep.28356","volume":"63","author":"J Boursier","year":"2016","unstructured":"Boursier J, Mueller O, Barret M, Machado M, Fizanne L, Araujo-Perez F, Guy CD, Seed PC, Rawls JF, David LA, Hunault G, Oberti F, Cal\u00e8s P, Diehl AM (2016) The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 63(3):764\u2013775. https:\/\/doi.org\/10.1002\/hep.28356","journal-title":"Hepatology"},{"issue":"11","key":"10262_CR20","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/s41371-022-00698-6","volume":"36","author":"SK Masenga","year":"2022","unstructured":"Masenga SK, Hamooya B, Hangoma J, Hayumbu V, Ertuglu LA, Ishimwe J, Rahman S, Saleem M, Laffer CL, Elijovich F, Kirabo A (2022) Recent advances in modulation of cardiovascular diseases by the gut microbiota. J Hum Hypertens 36(11):952\u2013959. https:\/\/doi.org\/10.1038\/s41371-022-00698-6","journal-title":"J Hum Hypertens"},{"key":"10262_CR21","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.bbrc.2023.05.041","volume":"669","author":"F Nian","year":"2023","unstructured":"Nian F, Zhu C, Jin N, Xia Q, Wu L, Lu X (2023) Gut microbiota metabolite TMAO promoted lipid deposition and fibrosis process via KRT17 in fatty liver cells in vitro. Biochem Biophys Res Commun 669:134\u2013142. https:\/\/doi.org\/10.1016\/j.bbrc.2023.05.041","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10262_CR22","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.fertnstert.2020.01.027","volume":"113","author":"W Chu","year":"2022","unstructured":"Chu W, Han Q, Xu J, Wang J, Sun Y, Li W, Chen ZJ, Du Y (2022) Metagenomic analysis identified microbiome alterations and pathological association between intestinal microbiota and polycystic ovary syndrome. Fertility and Sterility 113(6):1286\u20131298.e4. https:\/\/doi.org\/10.1016\/j.fertnstert.2020.01.027","journal-title":"Fertility and Sterility"},{"issue":"7","key":"10262_CR23","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1210\/jc.2017-02799","volume":"103","author":"M Insenser","year":"2018","unstructured":"Insenser M, Murri M, Del Campo R, Martinez-Garcia MA, Fernandez-Duran E, Escobar-Morreale HF (2018) Gut microbiota and the polycystic ovary syndrome: influence of sex, sex hormones, and obesity. J Clin Endocrinol Metab 103(7):2552\u20132562. https:\/\/doi.org\/10.1210\/jc.2017-02799","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10262_CR24","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","volume":"25","author":"X Qi","year":"2019","unstructured":"Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, Wang L, Zhang Y, Liang X, Wang L (2019) Gut microbiota\u2013bile acid\u2013interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med 25(8):1225\u20131233.\u00a0https:\/\/doi.org\/10.1038\/s41591-019-0509-0","journal-title":"Nat Med"},{"issue":"1","key":"10262_CR25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.resmic.2018.09.002","volume":"170","author":"B Zeng","year":"2019","unstructured":"Zeng B, Lai Z, Sun L, Zhang Z, Yang J, Li Z, Lin J, Zhang Z (2019) Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study. Res Microbiol 170(1):43\u201352. https:\/\/doi.org\/10.1016\/j.resmic.2018.09.002","journal-title":"Res Microbiol"},{"issue":"11","key":"10262_CR26","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1139\/cjpp-2019-0413","volume":"98","author":"Y Liang","year":"2020","unstructured":"Liang Y, Ming Q, Liang J, Zhang Y, Zhang H, Shen T (2020) Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity\u2014a preliminary report. Can J Physiol Pharmacol 98(11):803\u2013809. https:\/\/doi.org\/10.1139\/cjpp-2019-0413","journal-title":"Can J Physiol Pharmacol"},{"key":"10262_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112094","volume":"142","author":"L Duan","year":"2021","unstructured":"Duan L, An X, Zhang Y, Jin D, Zhao S, Zhou R, Duan Y, Zhang Y, Liu X, Lian F (2021) Gut microbiota as the critical correlation of polycystic ovary syndrome and type 2 diabetes mellitus. Biomed Pharmacother 142:112094. https:\/\/doi.org\/10.1016\/j.biopha.2021.112094","journal-title":"Biomed Pharmacother"},{"key":"10262_CR28","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00449-020-02320-w","volume":"44","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Yu J, Liang C, Li S, Wen X, Li Y (2021) Characterization on gut microbiome of PCOS rats and its further design by shifts in high-fat diet and dihydrotestosterone induction in PCOS rats. Bioprocess Biosyst Eng 44:953\u2013964. https:\/\/doi.org\/10.1007\/s00449-020-02320-w","journal-title":"Bioprocess Biosyst Eng"},{"key":"10262_CR29","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3389\/fendo.2020.00628","volume":"11","author":"L Zhou","year":"2020","unstructured":"Zhou L, Ni Z, Yu J, Cheng W, Cai Z, Yu C (2020) Correlation between fecal metabolomics and gut microbiota in obesity and polycystic ovary syndrome. Front Endocrinol 11:628. https:\/\/doi.org\/10.3389\/fendo.2020.00628","journal-title":"Front Endocrinol"},{"issue":"6","key":"10262_CR30","doi-asserted-by":"publisher","first-page":"e2134","DOI":"10.1210\/clinem\/dgz263","volume":"105","author":"B Jobira","year":"2020","unstructured":"Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M (2020) Obese adolescents with PCOS have altered biodiversity and relative abundance in gastrointestinal microbiota. J Clin Endocrinol Metab 105(6):e2134\u2013e2144. https:\/\/doi.org\/10.1210\/clinem\/dgz263","journal-title":"J Clin Endocrinol Metab"},{"key":"10262_CR31","doi-asserted-by":"publisher","unstructured":"Zhou J, Qiu X, Chen X, Ma S, Chen Z, Wang R, Tian Y, Jiang Y, Fan L, Wang J (2023) Comprehensive analysis of gut microbiota alteration in the patients and animal models with polycystic ovary syndrome.\u00a0J Microbiol 1\u201316. https:\/\/doi.org\/10.1007\/s12275-023-00079-9","DOI":"10.1007\/s12275-023-00079-9"},{"issue":"1","key":"10262_CR32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","volume":"81","author":"Eshre T R, Group A-S P C W","year":"2004","unstructured":"Eshre T R, Group A-S P C W (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81(1):19\u201325. https:\/\/doi.org\/10.1016\/j.fertnstert.2003.10.004","journal-title":"Fertil Steril"},{"issue":"2","key":"10262_CR33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/ajum.12096","volume":"21","author":"ME Smet","year":"2018","unstructured":"Smet ME, McLennan A (2018) Rotterdam criteria, the end. Australasian Journal of Ultrasound in Medicine 21(2):59. https:\/\/doi.org\/10.1002\/ajum.12096","journal-title":"Australasian Journal of Ultrasound in Medicine"},{"issue":"2","key":"10262_CR34","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1093\/humrep\/dep399","volume":"25","author":"WA March","year":"2010","unstructured":"March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ (2010) The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Human reproduction (Oxford, England) 25(2):544\u2013551. https:\/\/doi.org\/10.1093\/humrep\/dep399","journal-title":"Human reproduction (Oxford, England)"},{"issue":"6","key":"10262_CR35","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/jc.2003-032046","volume":"89","author":"R Azziz","year":"2004","unstructured":"Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO (2004) The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 89(6):2745\u20132749. https:\/\/doi.org\/10.1210\/jc.2003-032046","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10262_CR36","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nrendo.2018.24","volume":"14","author":"HF Escobar-Morreale","year":"2018","unstructured":"Escobar-Morreale HF (2018) Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol 14(5):270\u2013284. https:\/\/doi.org\/10.1038\/nrendo.2018.24","journal-title":"Nat Rev Endocrinol"},{"key":"10262_CR37","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ygcen.2017.12.007","volume":"260","author":"NA Malini","year":"2018","unstructured":"Malini NA, Roy George K (2018) Evaluation of different ranges of LH:FSH ratios in polycystic ovarian syndrome (PCOS) \u2013 clinical based case control study. Gen Comp Endocrinol 260:51\u201357. https:\/\/doi.org\/10.1016\/j.ygcen.2017.12.007","journal-title":"Gen Comp Endocrinol"},{"issue":"10","key":"10262_CR38","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/aogs.13395","volume":"97","author":"T Tanbo","year":"2018","unstructured":"Tanbo T, Mellembakken J, Bjercke S, Ring E, \u00c5byholm T, Fedorcsak P (2018) Ovulation induction in polycystic ovary syndrome. Acta Obstet Gynecol Scand 97(10):1162\u20131167. https:\/\/doi.org\/10.1111\/aogs.13395","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10262_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.01.001","volume":"35","author":"MA Sanchez-Garrido","year":"2020","unstructured":"Sanchez-Garrido MA, Tena-Sempere M (2020) Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies. Molecular Metabolism 35:100937. https:\/\/doi.org\/10.1016\/j.molmet.2020.01.001","journal-title":"Molecular Metabolism"},{"key":"10262_CR40","doi-asserted-by":"publisher","unstructured":"Misso M, Boyle J, Norman R, Teede H (2014) Development of evidenced-based guidelines for PCOS and implications for community health. in Seminars in reproductive medicine. Thieme Medical Publishers. https:\/\/doi.org\/10.1055\/s-0034-1371095","DOI":"10.1055\/s-0034-1371095"},{"issue":"4","key":"10262_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153196","volume":"11","author":"Y Guo","year":"2016","unstructured":"Guo Y, Qi Y, Yang X, Zhao L, Wen S, Liu Y, Tang L (2016) Association between polycystic ovary syndrome and gut microbiota. PLoS ONE 11(4):e0153196. https:\/\/doi.org\/10.1371\/journal.pone.0153196","journal-title":"PLoS ONE"},{"issue":"2","key":"10262_CR42","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/rmb2.12262","volume":"18","author":"S Osuka","year":"2019","unstructured":"Osuka S, Nakanishi N, Murase T, Nakamura T, Goto M, Iwase A, Kikkawa F (2019) Animal models of polycystic ovary syndrome: a review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides. Reproductive medicine and biology 18(2):151\u2013160. https:\/\/doi.org\/10.1002\/rmb2.12262","journal-title":"Reproductive medicine and biology"},{"issue":"1","key":"10262_CR43","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s40168-021-01046-5","volume":"9","author":"Q Han","year":"2021","unstructured":"Han Q, Wang J, Li W, Chen Z-J, Du Y (2021) Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome. Microbiome 9(1):101. https:\/\/doi.org\/10.1186\/s40168-021-01046-5","journal-title":"Microbiome"},{"issue":"1","key":"10262_CR44","doi-asserted-by":"publisher","first-page":"2183685","DOI":"10.1080\/19490976.2023.2183685","volume":"15","author":"T-H Hsiao","year":"2023","unstructured":"Hsiao T-H, Chou C-H, Chen Y-L, Wang P-H, Brandon-Mong G-J, Lee T-H, Wu T-Y, Li P-T, Li C-W, Lai Y-L (2023) Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut. Gut Microbes 15(1):2183685. https:\/\/doi.org\/10.1080\/19490976.2023.2183685","journal-title":"Gut Microbes"},{"key":"10262_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2021.100284","volume":"20","author":"AC Organski","year":"2021","unstructured":"Organski AC, Jorgensen JS, Cross T-WL (2021) Involving the life inside: the complex interplay between reproductive axis hormones and gut microbiota. Current Opinion in Endocrine and Metabolic Research 20:100284. https:\/\/doi.org\/10.1016\/j.coemr.2021.100284","journal-title":"Current Opinion in Endocrine and Metabolic Research"},{"issue":"1","key":"10262_CR46","doi-asserted-by":"publisher","first-page":"11967","DOI":"10.1038\/s41598-023-39168-5","volume":"13","author":"J Patel","year":"2023","unstructured":"Patel J, Chaudhary H, Rajput K, Parekh B, Joshi R (2023) Assessment of gut microbial \u03b2-glucuronidase and \u03b2-glucosidase activity in women with polycystic ovary syndrome. Sci Rep 13(1):11967. https:\/\/doi.org\/10.1038\/s41598-023-39168-5","journal-title":"Sci Rep"},{"issue":"1","key":"10262_CR47","doi-asserted-by":"publisher","first-page":"196","DOI":"10.4143\/crt.2022.080","volume":"55","author":"C-H Song","year":"2022","unstructured":"Song C-H, Kim N, Nam RH, Choi SI, Jang JY, Lee H-N (2022) Changes in gut microbiome upon orchiectomy and testosterone administration in AOM\/DSS-induced colon cancer mouse model. Cancer Research and Treatment: Official Journal of Korean Cancer Association 55(1):196\u2013218. https:\/\/doi.org\/10.4143\/crt.2022.080","journal-title":"Cancer Research and Treatment: Official Journal of Korean Cancer Association"},{"key":"10262_CR48","doi-asserted-by":"publisher","unstructured":"Kumari N, Kumari R, Dua A, Singh M, Kumar R, Singh P, Duyar-Ayerdi S, Pradeep S, Ojesina A I, Kumar R From gut to hormones: unraveling the role of gut microbiota in (phyto)estrogen modulation in health and disease. Molecular Nutrition & Food Research. (n\/a): 2300688. https:\/\/doi.org\/10.1002\/mnfr.202300688","DOI":"10.1002\/mnfr.202300688"},{"key":"10262_CR49","doi-asserted-by":"publisher","unstructured":"Rizk M G, Thackray V G (2020) Intersection of polycystic ovary syndrome and the gut microbiome. Journal of the Endocrine Society\u00a05(2). https:\/\/doi.org\/10.1210\/jendso\/bvaa177","DOI":"10.1210\/jendso\/bvaa177"},{"issue":"6","key":"10262_CR50","doi-asserted-by":"publisher","first-page":"5192","DOI":"10.1039\/C9FO02554E","volume":"11","author":"Y He","year":"2020","unstructured":"He Y, Wang Q, Li X, Wang G, Zhao J, Zhang H, Chen W (2020) Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota. Food Funct 11(6):5192\u20135204. https:\/\/doi.org\/10.1039\/C9FO02554E","journal-title":"Food Funct"},{"key":"10262_CR51","doi-asserted-by":"publisher","unstructured":"Guo J, Shao J, Yang Y, Niu X, Liao J, Zhao Q, Wang D, Li S, Hu J (2022) Gut microbiota in patients with polycystic ovary syndrome: a systematic review. Reproductive Sciences. 1\u201315. https:\/\/doi.org\/10.1007\/s43032-020-00430-0","DOI":"10.1007\/s43032-020-00430-0"},{"key":"10262_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.836896","volume":"13","author":"Y-L Tsai","year":"2022","unstructured":"Tsai Y-L, Liu Y-W, Wang P-N, Lin C-Y, Lan T-H (2022) Gender differences in gut microbiome composition between schizophrenia patients with normal body weight and central obesity. Front Psych 13:836896. https:\/\/doi.org\/10.3389\/fpsyt.2022.836896","journal-title":"Front Psych"},{"issue":"2","key":"10262_CR53","doi-asserted-by":"publisher","first-page":"151472","DOI":"10.1016\/j.ijmm.2021.151472","volume":"311","author":"A Iljazovic","year":"2011","unstructured":"Iljazovic A, Amend L, Galvez E J C, de Oliveira R, Strowig T (2011) Modulation of inflammatory responses by gastrointestinal Prevotella spp. \u2013 from associations to functional studies. Int J Med Microbiol 311(2):151472. https:\/\/doi.org\/10.1016\/j.ijmm.2021.151472","journal-title":"Int J Med Microbiol"},{"issue":"1","key":"10262_CR54","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12986-020-00516-1","volume":"17","author":"Q Zhou","year":"2020","unstructured":"Zhou Q, Zhang Y, Wang X, Yang R, Zhu X, Zhang Y, Chen C, Yuan H, Yang Z, Sun L (2020) Gut bacteria Akkermansia is associated with reduced risk of obesity: evidence from the American Gut Project. Nutr Metab 17(1):90. https:\/\/doi.org\/10.1186\/s12986-020-00516-1","journal-title":"Nutr Metab"},{"issue":"1","key":"10262_CR55","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","volume":"26","author":"TS Postler","year":"2017","unstructured":"Postler TS, Ghosh S (2017) Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metab 26(1):110\u2013130. https:\/\/doi.org\/10.1016\/j.cmet.2017.05.008","journal-title":"Cell Metab"},{"key":"10262_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.933110","volume":"13","author":"M Zhang","year":"2022","unstructured":"Zhang M, Hu R, Huang Y, Zhou F, Li F, Liu Z, Geng Y, Dong H, Ma W, Song K (2022) Present and future: crosstalks between polycystic ovary syndrome and gut metabolites relating to gut microbiota. Front Endocrinol 13:933110. https:\/\/doi.org\/10.3389\/fendo.2022.933110","journal-title":"Front Endocrinol"},{"issue":"28","key":"10262_CR57","doi-asserted-by":"publisher","first-page":"25481","DOI":"10.1074\/jbc.M301403200","volume":"278","author":"E Le Poul","year":"2003","unstructured":"Le Poul E, Loison C, Struyf S, Springael J-Y, Lannoy V, Decobecq M-E, Brezillon S, Dupriez V, Vassart G, Van Damme J, Parmentier M, Detheux M (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278(28):25481\u201325489. https:\/\/doi.org\/10.1074\/jbc.M301403200","journal-title":"J Biol Chem"},{"issue":"13","key":"10262_CR58","doi-asserted-by":"publisher","first-page":"11312","DOI":"10.1074\/jbc.M211609200","volume":"278","author":"AJ Brown","year":"2003","unstructured":"Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ (2003) The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278(13):11312\u201311319. https:\/\/doi.org\/10.1074\/jbc.M211609200","journal-title":"J Biol Chem"},{"issue":"3","key":"10262_CR59","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1124\/mol.115.102301","volume":"89","author":"D Bolognini","year":"2016","unstructured":"Bolognini D, Tobin AB, Milligan G, Moss CE (2016) The pharmacology and function of receptors for short-chain fatty acids. Mol Pharmacol 89(3):388\u2013398. https:\/\/doi.org\/10.1124\/mol.115.102301","journal-title":"Mol Pharmacol"},{"key":"10262_CR60","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11154-014-9288-6","volume":"15","author":"A Everard","year":"2014","unstructured":"Everard A, Cani PD (2014) Gut microbiota and GLP-1. Rev Endocr Metab Disord 15:189\u2013196. https:\/\/doi.org\/10.1007\/s11154-014-9288-6","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"10262_CR61","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1017\/S0029665120006916","volume":"80","author":"C Martin-Gallausiaux","year":"2021","unstructured":"Martin-Gallausiaux C, Marinelli L, Blotti\u00e8re HM, Larraufie P, Lapaque N (2021) SCFA: mechanisms and functional importance in the gut. Proceedings of the Nutrition Society 80(1):37\u201349. https:\/\/doi.org\/10.1017\/S0029665120006916","journal-title":"Proceedings of the Nutrition Society"},{"key":"10262_CR62","doi-asserted-by":"publisher","unstructured":"Ferreira C M, Vieira A T, Vinolo M A R, Oliveira F A, Curi R, Martins F d S (2014) The central role of the gut microbiota in chronic inflammatory diseases.\u00a0J Immunol Res. \u00a0https:\/\/doi.org\/10.1155\/2014\/689492","DOI":"10.1155\/2014\/689492"},{"issue":"35","key":"10262_CR63","doi-asserted-by":"publisher","first-page":"25088","DOI":"10.1074\/jbc.M113.452516","volume":"288","author":"H Yadav","year":"2013","unstructured":"Yadav H, Lee J-H, Lloyd J, Walter P, Rane SG (2013) Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. J Biol Chem 288(35):25088\u201325097. https:\/\/doi.org\/10.1074\/jbc.M113.452516","journal-title":"J Biol Chem"},{"issue":"9","key":"10262_CR64","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/s42255-020-0188-7","volume":"2","author":"J Frampton","year":"2020","unstructured":"Frampton J, Murphy KG, Frost G, Chambers ES (2020) Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function. Nat Metab 2(9):840\u2013848. https:\/\/doi.org\/10.1038\/s42255-020-0188-7","journal-title":"Nat Metab"},{"issue":"7","key":"10262_CR65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272124","volume":"17","author":"KS Olaniyi","year":"2022","unstructured":"Olaniyi KS, Bashir A-a M, Areloegbe SE, Sabinari IW, Akintayo CO, Oniyide AA, Aturamu A (2022) Short chain fatty acid, acetate restores ovarian function in experimentally induced PCOS rat model. PLoS ONE 17(7):e0272124. https:\/\/doi.org\/10.1371\/journal.pone.0272124","journal-title":"PLoS ONE"},{"issue":"1","key":"10262_CR66","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","volume":"9","author":"DV Guzior","year":"2021","unstructured":"Guzior DV, Quinn RA (2021) Review: microbial transformations of human bile acids. Microbiome 9(1):140. https:\/\/doi.org\/10.1186\/s40168-021-01101-1","journal-title":"Microbiome"},{"key":"10262_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111036","volume":"133","author":"L Wu","year":"2021","unstructured":"Wu L, Feng J, Li J, Yu Q, Ji J, Wu J, Dai W, Guo C (2021) The gut microbiome-bile acid axis in hepatocarcinogenesis. Biomed Pharmacother 133:111036. https:\/\/doi.org\/10.1016\/j.biopha.2020.111036","journal-title":"Biomed Pharmacother"},{"key":"10262_CR68","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jsbmb.2019.03.005","volume":"189","author":"B Zhang","year":"2019","unstructured":"Zhang B, Shen S, Gu T, Hong T, Liu J, Sun J, Wang H, Bi Y, Zhu D (2019) Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol 189:171\u2013175. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.03.005","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"10262_CR69","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1515\/jtim-2016-0018","volume":"4","author":"GH Tomkin","year":"2016","unstructured":"Tomkin GH, Owens D (2016) Obesity diabetes and the role of bile acids in metabolism. Journal of Translational Internal Medicine 4(2):73\u201380. https:\/\/doi.org\/10.1515\/jtim-2016-0018","journal-title":"Journal of Translational Internal Medicine"},{"issue":"10","key":"10262_CR70","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1136\/gutjnl-2017-314307","volume":"67","author":"N Jiao","year":"2018","unstructured":"Jiao N, Baker SS, Chapa-Rodriguez A, Liu W, Nugent CA, Tsompana M, Mastrandrea L, Buck MJ, Baker RD, Genco RJ (2018) Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut 67(10):1881\u20131891. https:\/\/doi.org\/10.1136\/gutjnl-2017-314307","journal-title":"Gut"},{"key":"10262_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105776","volume":"125","author":"LA Jones","year":"2020","unstructured":"Jones LA, Sun EW, Martin AM, Keating DJ (2020) The ever-changing roles of serotonin. Int J Biochem Cell Biol 125:105776. https:\/\/doi.org\/10.1016\/j.biocel.2020.105776","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"10262_CR72","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.tem.2007.07.003","volume":"18","author":"HF Escobar-Morreale","year":"2007","unstructured":"Escobar-Morreale HF, San Mill\u00e1n JL (2007) Abdominal adiposity and the polycystic ovary syndrome. Trends Endocrinol Metab 18(7):266\u2013272. https:\/\/doi.org\/10.1016\/j.tem.2007.07.003","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"10262_CR73","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1210\/jc.2009-2724","volume":"95","author":"RA Wild","year":"2010","unstructured":"Wild RA, Carmina E, Diamanti-Kandarakis E, Dokras A, Escobar-Morreale HF, Futterweit W, Lobo R, Norman RJ, Talbott E, Dumesic DA (2010) Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab 95(5):2038\u20132049. https:\/\/doi.org\/10.1210\/jc.2009-2724","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10262_CR74","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/pedi.13206","volume":"22","author":"J Hudnut-Beumler","year":"2021","unstructured":"Hudnut-Beumler J, Kaar JL, Taylor A, Kelsey MM, Nadeau KJ, Zeitler P, Snell-Bergeon J, Pyle L, Cree-Green M (2021) Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity. Pediatr Diabetes 22(5):699\u2013706. https:\/\/doi.org\/10.1111\/pedi.13206","journal-title":"Pediatr Diabetes"},{"issue":"7","key":"10262_CR75","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/sj.ijo.0801994","volume":"26","author":"A Gambineri","year":"2002","unstructured":"Gambineri A, Pelusi C, Vicennati V, Pagotto U, Pasquali R (2002) Obesity and the polycystic ovary syndrome. Int J Obes 26(7):883\u2013896. https:\/\/doi.org\/10.1038\/sj.ijo.0801994","journal-title":"Int J Obes"},{"issue":"9","key":"10262_CR76","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1093\/humrep\/16.9.1995","volume":"16","author":"RJ Norman","year":"2001","unstructured":"Norman RJ, Masters L, Milner CR, Wang JX, Davies MJ (2001) Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome. Human reproduction (Oxford, England) 16(9):1995\u20131998. https:\/\/doi.org\/10.1093\/humrep\/16.9.1995","journal-title":"Human reproduction (Oxford, England)"},{"issue":"1","key":"10262_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2265.1993.tb01744.x","volume":"39","author":"R Pasquali","year":"1993","unstructured":"Pasquali R, Casimirri F (1993) The impact of obesity on hyperandrogenism and polycystic ovary syndrome in premenopausal women. Clin Endocrinol 39(1):1\u201316. https:\/\/doi.org\/10.1111\/j.1365-2265.1993.tb01744.x","journal-title":"Clin Endocrinol"},{"issue":"6","key":"10262_CR78","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3109\/09513590.2012.760195","volume":"29","author":"K Ebejer","year":"2013","unstructured":"Ebejer K, Calleja-Agius J (2013) The role of cytokines in polycystic ovarian syndrome. Gynecol Endocrinol 29(6):536\u2013540. https:\/\/doi.org\/10.3109\/09513590.2012.760195","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"10262_CR79","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1080\/07315724.2019.1657515","volume":"39","author":"G Yurtda\u015f","year":"2020","unstructured":"Yurtda\u015f G, Akdevelio\u011flu Y (2020) A new approach to polycystic ovary syndrome: the gut microbiota. J Am Coll Nutr 39(4):371\u2013382. https:\/\/doi.org\/10.1080\/07315724.2019.1657515","journal-title":"J Am Coll Nutr"},{"issue":"1","key":"10262_CR80","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s12967-023-04116-4","volume":"21","author":"S Shabbir","year":"2023","unstructured":"Shabbir S, Khurram E, Moorthi VS, Eissa YTH, Kamal MA, Butler AE (2023) The interplay between androgens and the immune response in polycystic ovary syndrome. J Transl Med 21(1):259. https:\/\/doi.org\/10.1186\/s12967-023-04116-4","journal-title":"J Transl Med"},{"issue":"1","key":"10262_CR81","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.repbio.2015.12.005","volume":"16","author":"V Pandey","year":"2016","unstructured":"Pandey V, Singh A, Singh A, Krishna A, Pandey U, Tripathi YB (2016) Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat. Reprod Biol 16(1):70\u201377. https:\/\/doi.org\/10.1016\/j.repbio.2015.12.005","journal-title":"Reprod Biol"},{"issue":"3","key":"10262_CR82","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/humupd\/dms059","volume":"19","author":"M Murri","year":"2013","unstructured":"Murri M, Luque-Ram\u00edrez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF (2013) Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum Reprod Update 19(3):268\u2013288. https:\/\/doi.org\/10.1093\/humupd\/dms059","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10262_CR83","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jpag.2014.05.003","volume":"28","author":"V Turan","year":"2015","unstructured":"Turan V, Sezer ED, Zeybek B, Sendag F (2015) Infertility and the presence of insulin resistance are associated with increased oxidative stress in young, non-obese Turkish women with polycystic ovary syndrome. J Pediatr Adolesc Gynecol 28(2):119\u2013123. https:\/\/doi.org\/10.1016\/j.jpag.2014.05.003","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"6","key":"10262_CR84","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1210\/jcem.86.6.7580","volume":"86","author":"CCJ Kelly","year":"2001","unstructured":"Kelly CCJ, Lyall H, Petrie JR, Gould GW, Connell JMC, Sattar N (2001) Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 86(6):2453\u20132455. https:\/\/doi.org\/10.1210\/jcem.86.6.7580","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10262_CR85","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12863-015-0165-4","volume":"16","author":"R Guo","year":"2015","unstructured":"Guo R, Zheng Y, Yang J, Zheng N (2015) Association of TNF-alpha, IL-6 and IL-1beta gene polymorphisms with polycystic ovary syndrome: a meta-analysis. BMC Genet 16(1):5. https:\/\/doi.org\/10.1186\/s12863-015-0165-4","journal-title":"BMC Genet"},{"issue":"2","key":"10262_CR86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148531","volume":"11","author":"Z Peng","year":"2016","unstructured":"Peng Z, Sun Y, Lv X, Zhang H, Liu C, Dai S (2016) Interleukin-6 levels in women with polycystic ovary syndrome: a systematic review and meta-analysis. PLoS ONE 11(2):e0148531. https:\/\/doi.org\/10.1371\/journal.pone.0148531","journal-title":"PLoS ONE"},{"issue":"4","key":"10262_CR87","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.tjog.2019.05.003","volume":"58","author":"Q Liu","year":"2019","unstructured":"Liu Q, Xie Y-J, Qu L-H, Zhang M-X, Mo Z-C (2019) Dyslipidemia involvement in the development of polycystic ovary syndrome. Taiwan J Obstet Gynecol 58(4):447\u2013453. https:\/\/doi.org\/10.1016\/j.tjog.2019.05.003","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"3","key":"10262_CR88","doi-asserted-by":"publisher","first-page":"137","DOI":"10.5468\/ogs.2013.56.3.137","volume":"56","author":"JJ Kim","year":"2013","unstructured":"Kim JJ, Choi YM (2013) Dyslipidemia in women with polycystic ovary syndrome. Obstetrics & gynecology science 56(3):137\u2013142. https:\/\/doi.org\/10.5468\/ogs.2013.56.3.137","journal-title":"Obstetrics & gynecology science"},{"issue":"6","key":"10262_CR89","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/S0015-0282(02)03111-4","volume":"77","author":"F Ovalle","year":"2002","unstructured":"Ovalle F, Azziz R (2002) Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertil Steril 77(6):1095\u20131105. https:\/\/doi.org\/10.1016\/S0015-0282(02)03111-4","journal-title":"Fertil Steril"},{"issue":"4","key":"10262_CR90","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.3390\/ijms25042237","volume":"25","author":"G Cocomazzi","year":"2024","unstructured":"Cocomazzi G, Del Pup L, Contu V, Maggio G, Parmegiani L, Ciampaglia W, De Ruvo D, Faioli R, Maglione A, Baldini GM, Baldini D, Pazienza V (2024) Gynecological cancers and microbiota dynamics: insights into pathogenesis and therapy. Int J Mol Sci 25(4):2237","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10262_CR91","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1042\/BCJ20160510","volume":"474","author":"E Thursby","year":"2017","unstructured":"Thursby E, Juge N (2017) Introduction to the human gut microbiota. Biochem J 474(11):1823\u20131836. https:\/\/doi.org\/10.1042\/BCJ20160510","journal-title":"Biochem J"},{"issue":"43","key":"10262_CR92","doi-asserted-by":"publisher","first-page":"16731","DOI":"10.1073\/pnas.0804812105","volume":"105","author":"H Sokol","year":"2008","unstructured":"Sokol H, Pigneur B, Watterlot L, Lakhdari O, Berm\u00fadez-Humar\u00e1n LG, Gratadoux J-J, Blugeon S, Bridonneau C, Furet J-P, Corthier G (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci 105(43):16731\u201316736. https:\/\/doi.org\/10.1073\/pnas.0804812105","journal-title":"Proc Natl Acad Sci"},{"key":"10262_CR93","doi-asserted-by":"publisher","unstructured":"Gurung M, Li Z, You H, Rodrigues R, Jump D B, Morgun A, Shulzhenko N (2020) Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 51. https:\/\/doi.org\/10.1016\/j.ebiom.2019.11.051","DOI":"10.1016\/j.ebiom.2019.11.051"},{"key":"10262_CR94","doi-asserted-by":"publisher","first-page":"114985","DOI":"10.1016\/j.biopha.2023.114985","volume":"164","author":"M Zhao","year":"2023","unstructured":"Zhao MA, Chu J, Feng S, Guo C, Xue B, He K, Li L (2023) Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: a review. Biomed Pharmacother 164","journal-title":"Biomed Pharmacother"},{"key":"10262_CR95","doi-asserted-by":"publisher","unstructured":"Tejkalov\u00e1 H, Jakob L, Kvasnov\u00e1 S, Klaschka J, Sechovcov\u00e1 H, Mr\u00e1zek J, P\u00e1len\u00ed\u010dek T, Fliegerov\u00e1 KO (2023) The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide. Heliyon 9(4). https:\/\/doi.org\/10.1016\/j.heliyon.2023.e15417","DOI":"10.1016\/j.heliyon.2023.e15417"},{"key":"10262_CR96","doi-asserted-by":"publisher","unstructured":"Williams BL, Hornig M, Parekh T, Lipkin WI (2012) Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. mBio. 3(1).\u00a0https:\/\/doi.org\/10.1128\/mbio.00261-11","DOI":"10.1128\/mbio.00261-11"},{"issue":"9","key":"10262_CR97","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1111\/jgh.14129","volume":"33","author":"A Hirano","year":"2018","unstructured":"Hirano A, Umeno J, Okamoto Y, Shibata H, Ogura Y, Moriyama T, Torisu T, Fujioka S, Fuyuno Y, Kawarabayasi Y (2018) Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis. J Gastroenterol Hepatol 33(9):1590\u20131597. https:\/\/doi.org\/10.1111\/jgh.14129","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10262_CR98","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s12916-023-02975-8","volume":"21","author":"P Li","year":"2023","unstructured":"Li P, Shuai P, Shen S, Zheng H, Sun P, Zhang R, Lan S, Lan Z, Jayawardana T, Yang Y (2023) Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis. BMC Med 21(1):302. https:\/\/doi.org\/10.1186\/s12916-023-02975-8","journal-title":"BMC Med"},{"issue":"1","key":"10262_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13048-021-00799-9","volume":"14","author":"F He","year":"2021","unstructured":"He F, Li Y (2021) The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal-weight population. Journal of Ovarian Research 14(1):1\u201312. https:\/\/doi.org\/10.1186\/s13048-021-00799-9","journal-title":"Journal of Ovarian Research"},{"key":"10262_CR100","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s12020-013-0087-8","volume":"45","author":"JM Pappachan","year":"2014","unstructured":"Pappachan JM, Antonio FA, Edavalath M, Mukherjee A (2014) Non-alcoholic fatty liver disease: a diabetologist\u2019s perspective. Endocrine 45:344\u2013353. https:\/\/doi.org\/10.1007\/s12020-013-0087-8","journal-title":"Endocrine"},{"issue":"8","key":"10262_CR101","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.1210\/en.2014-1196","volume":"155","author":"ASL Caldwell","year":"2014","unstructured":"Caldwell ASL, Middleton LJ, Jimenez M, Desai R, McMahon AC, Allan CM, Handelsman DJ, Walters KA (2014) Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models. Endocrinology 155(8):3146\u20133159. https:\/\/doi.org\/10.1210\/en.2014-1196","journal-title":"Endocrinology"},{"key":"10262_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104103","volume":"73","author":"X Li","year":"2020","unstructured":"Li X, Huang Y, Song L, Xiao Y, Lu S, Xu J, Li J, Ren Z (2020) Lactobacillus plantarum prevents obesity via modulation of gut microbiota and metabolites in high-fat feeding mice. Journal of Functional Foods 73:104103. https:\/\/doi.org\/10.1016\/j.jff.2020.104103","journal-title":"Journal of Functional Foods"},{"issue":"1","key":"10262_CR103","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/cen.14198","volume":"93","author":"X Hong","year":"2020","unstructured":"Hong X, Qin P, Huang K, Ding X, Ma J, Xuan Y, Zhu X, Peng D, Wang B (2020) Association between polycystic ovary syndrome and the vaginal microbiome: a case-control study. Clin Endocrinol 93(1):52\u201360. https:\/\/doi.org\/10.1111\/cen.14198","journal-title":"Clin Endocrinol"},{"issue":"1","key":"10262_CR104","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1210\/clinem\/dgab658","volume":"107","author":"C Falzarano","year":"2021","unstructured":"Falzarano C, Lofton T, Osei-Ntansah A, Oliver T, Southward T, Stewart S, Andrisse S (2021) Nonalcoholic fatty liver disease in women and girls with polycystic ovary syndrome. J Clin Endocrinol Metab 107(1):258\u2013272. https:\/\/doi.org\/10.1210\/clinem\/dgab658","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10262_CR105","doi-asserted-by":"publisher","first-page":"3709","DOI":"10.1210\/jc.2012-1382","volume":"97","author":"H Jones","year":"2012","unstructured":"Jones H, Sprung VS, Pugh CJA, Daousi C, Irwin A, Aziz N, Adams VL, Thomas EL, Bell JD, Kemp GJ, Cuthbertson DJ (2012) Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance. J Clin Endocrinol Metab 97(10):3709\u20133716. https:\/\/doi.org\/10.1210\/jc.2012-1382","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10262_CR106","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ecl.2023.01.005","volume":"52","author":"P Vidal-Cevallos","year":"2023","unstructured":"Vidal-Cevallos P, Mijangos-Trejo A, Uribe M, Tapia NC (2023) The interlink between metabolic-associated fatty liver disease and polycystic ovary syndrome. Endocrinol Metab Clin 52(3):533\u2013545. https:\/\/doi.org\/10.1016\/j.ecl.2023.01.005","journal-title":"Endocrinol Metab Clin"},{"issue":"3","key":"10262_CR107","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","volume":"72","author":"A Albillos","year":"2020","unstructured":"Albillos A, De Gottardi A, Rescigno M (2020) The gut-liver axis in liver disease: pathophysiological basis for therapy. J Hepatol 72(3):558\u2013577. https:\/\/doi.org\/10.1016\/j.jhep.2019.10.003","journal-title":"J Hepatol"},{"issue":"1","key":"10262_CR108","doi-asserted-by":"publisher","first-page":"32002","DOI":"10.1038\/srep32002","volume":"6","author":"B Wang","year":"2016","unstructured":"Wang B, Jiang X, Cao M, Ge J, Bao Q, Tang L, Chen Y, Li L (2016) Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease. Sci Rep 6(1):32002. https:\/\/doi.org\/10.1038\/srep32002","journal-title":"Sci Rep"},{"issue":"6","key":"10262_CR109","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1007\/s12072-019-09987-8","volume":"13","author":"C Iino","year":"2019","unstructured":"Iino C, Endo T, Mikami K, Hasegawa T, Kimura M, Sawada N, Nakaji S, Fukuda S (2019) Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study. Hep Intl 13(6):748\u2013756. https:\/\/doi.org\/10.1007\/s12072-019-09987-8","journal-title":"Hep Intl"},{"issue":"6","key":"10262_CR110","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.numecd.2012.02.007","volume":"22","author":"D Compare","year":"2012","unstructured":"Compare D, Coccoli P, Rocco A, Nardone O, De Maria S, Carten\u00ec M, Nardone G (2012) Gut\u2013liver axis: the impact of gut microbiota on non alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 22(6):471\u2013476. https:\/\/doi.org\/10.1016\/j.numecd.2012.02.007","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"16","key":"10262_CR111","doi-asserted-by":"publisher","first-page":"4985","DOI":"10.1128\/AEM.00753-08","volume":"74","author":"J Walter","year":"2008","unstructured":"Walter J (2008) Ecological role of Lactobacilli in the gastrointestinal tract: implications for fundamental and biomedical research. Appl Environ Microbiol 74(16):4985\u20134996. https:\/\/doi.org\/10.1128\/AEM.00753-08","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"10262_CR112","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.immuni.2018.12.018","volume":"50","author":"J Schulthess","year":"2019","unstructured":"Schulthess J, Pandey S, Capitani M, Rue-Albrecht KC, Arnold I, Franchini F, Chomka A, Ilott NE, Johnston DG, Pires E (2019) The short chain fatty acid butyrate imprints an antimicrobial program in macrophages. Immunity 50(2):432\u2013455. e7.\u00a0https:\/\/doi.org\/10.1016\/j.immuni.2018.12.018","journal-title":"Immunity"},{"issue":"6","key":"10262_CR113","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1073\/pnas.1322269111","volume":"111","author":"PV Chang","year":"2014","unstructured":"Chang PV, Hao L, Offermanns S, Medzhitov R (2014) The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci 111(6):2247\u20132252. https:\/\/doi.org\/10.1073\/pnas.1322269111","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"10262_CR114","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1111\/jgh.16272","volume":"38","author":"IA Marcondes-de-Castro","year":"2023","unstructured":"Marcondes-de-Castro IA, Reis-Barbosa PH, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA (2023) AMPK\/mTOR pathway significance in healthy liver and non-alcoholic fatty liver disease and its progression. J Gastroenterol Hepatol 38(11):1868\u20131876. https:\/\/doi.org\/10.1111\/jgh.16272","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10262_CR115","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12902-019-0486-9","volume":"20","author":"J Huang","year":"2020","unstructured":"Huang J, Liu L, Chen C, Gao Y (2020) PCOS without hyperandrogenism is associated with higher plasma trimethylamine N-oxide levels. BMC Endocr Disord 20(1):3. https:\/\/doi.org\/10.1186\/s12902-019-0486-9","journal-title":"BMC Endocr Disord"},{"issue":"6","key":"10262_CR116","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1111\/cen.14101","volume":"91","author":"ND Eyupoglu","year":"2019","unstructured":"Eyupoglu ND, Caliskan Guzelce E, Acikgoz A, Uyanik E, Bj\u00f8rndal B, Berge RK, Svardal A, Yildiz BO (2019) Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome. Clin Endocrinol 91(6):810\u2013815. https:\/\/doi.org\/10.1111\/cen.14101","journal-title":"Clin Endocrinol"},{"issue":"1","key":"10262_CR117","doi-asserted-by":"publisher","first-page":"19076","DOI":"10.1038\/srep19076","volume":"6","author":"Y-M Chen","year":"2016","unstructured":"Chen Y-M, Liu Y, Zhou R-F, Chen X-l, Wang C, Tan X-Y, Wang L-J, Zheng R-D, Zhang H-W, Ling W-H, Zhu H-l (2016) Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. Sci Rep 6(1):19076. https:\/\/doi.org\/10.1038\/srep19076","journal-title":"Sci Rep"},{"issue":"1","key":"10262_CR118","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40168-017-0271-9","volume":"5","author":"S Rath","year":"2017","unstructured":"Rath S, Heidrich B, Pieper DH, Vital M (2017) Uncovering the trimethylamine-producing bacteria of the human gut microbiota. Microbiome 5(1):54. https:\/\/doi.org\/10.1186\/s40168-017-0271-9","journal-title":"Microbiome"},{"issue":"3","key":"10262_CR119","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.fertnstert.2010.12.027","volume":"95","author":"RA Wild","year":"2011","unstructured":"Wild RA, Rizzo M, Clifton S, Carmina E (2011) Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis. Fertil Steril 95(3):1073-1079.e11. https:\/\/doi.org\/10.1016\/j.fertnstert.2010.12.027","journal-title":"Fertil Steril"},{"issue":"12","key":"10262_CR120","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.1210\/jc.2011-1677","volume":"96","author":"J Schmidt","year":"2011","unstructured":"Schmidt J, Landin-Wilhelmsen K, Br\u00e4nnstr\u00f6m M, Dahlgren E (2011) Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study. J Clin Endocrinol Metab 96(12):3794\u20133803. https:\/\/doi.org\/10.1210\/jc.2011-1677","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10262_CR121","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.tcm.2019.08.010","volume":"30","author":"O Osibogun","year":"2020","unstructured":"Osibogun O, Ogunmoroti O, Michos ED (2020) Polycystic ovary syndrome and cardiometabolic risk: opportunities for cardiovascular disease prevention. Trends Cardiovasc Med 30(7):399\u2013404. https:\/\/doi.org\/10.1016\/j.tcm.2019.08.010","journal-title":"Trends Cardiovasc Med"},{"issue":"6","key":"10262_CR122","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1210\/jc.2003-030334","volume":"88","author":"RC Christian","year":"2003","unstructured":"Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF II, Fitzpatrick LA (2003) Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88(6):2562\u20132568. https:\/\/doi.org\/10.1210\/jc.2003-030334","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10262_CR123","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1161\/ATVBAHA.114.304136","volume":"34","author":"R Calderon-Margalit","year":"2014","unstructured":"Calderon-Margalit R, Siscovick D, Merkin SS, Wang E, Daviglus ML, Schreiner PJ, Sternfeld B, Williams OD, Lewis CE, Azziz R, Schwartz SM, Wellons MF (2014) Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness. Arterioscler Thromb Vasc Biol 34(12):2688\u20132694. https:\/\/doi.org\/10.1161\/ATVBAHA.114.304136","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10262_CR124","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1093\/humrep\/dep121","volume":"24","author":"M Rizzo","year":"2009","unstructured":"Rizzo M, Berneis K, Hersberger M, Pepe I, Di Fede G, Rini GB, Spinas GA, Carmina E (2009) Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype. Human reproduction (Oxford, England) 24(9):2286\u20132292. https:\/\/doi.org\/10.1093\/humrep\/dep121","journal-title":"Human reproduction (Oxford, England)"},{"issue":"3","key":"10262_CR125","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.fertnstert.2018.11.034","volume":"111","author":"LB Marchesan","year":"2019","unstructured":"Marchesan LB, Spritzer PM (2019) ACC\/AHA 2017 definition of high blood pressure: implications for women with polycystic ovary syndrome. Fertil Steril 111(3):579\u2013587.e1. https:\/\/doi.org\/10.1016\/j.fertnstert.2018.11.034","journal-title":"Fertil Steril"},{"issue":"11","key":"10262_CR126","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1210\/jc.2006-0399","volume":"91","author":"T Cascella","year":"2006","unstructured":"Cascella T, Palomba S, Tauchmanov\u00e0 L, Manguso F, Di Biase S, Labella D, Giallauria F, Vigorito C, Colao A, Lombardi G (2006) Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 91(11):4395\u20134400. https:\/\/doi.org\/10.1210\/jc.2006-0399","journal-title":"J Clin Endocrinol Metab"},{"key":"10262_CR127","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.toxlet.2016.12.017","volume":"267","author":"M Makrecka-Kuka","year":"2017","unstructured":"Makrecka-Kuka M, Volska K, Antone U, Vilskersts R, Grinberga S, Bandere D, Liepinsh E, Dambrova M (2017) Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett 267:32\u201338. https:\/\/doi.org\/10.1016\/j.toxlet.2016.12.017","journal-title":"Toxicol Lett"},{"key":"10262_CR128","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.trsl.2020.08.007","volume":"228","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Wang Y, Ke B, Du J (2021) TMAO: how gut microbiota contributes to heart failure. Transl Res 228:109\u2013125. https:\/\/doi.org\/10.1016\/j.trsl.2020.08.007","journal-title":"Transl Res"},{"issue":"1","key":"10262_CR129","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","volume":"165","author":"W Zhu","year":"2016","unstructured":"Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL (2016) Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165(1):111\u2013124. https:\/\/doi.org\/10.1016\/j.cell.2016.02.011","journal-title":"Cell"},{"issue":"1","key":"10262_CR130","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41522-022-00273-4","volume":"8","author":"YY Cai","year":"2022","unstructured":"Cai YY, Huang FQ, Lao X, Lu Y, Gao X, Alolga RN, Yin K, Zhou X, Wang Y, Liu B, Shang J, Qi LW, Li J (2022) Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis. npj Biofilms and Microbiomes 8(1):11. https:\/\/doi.org\/10.1038\/s41522-022-00273-4","journal-title":"npj Biofilms and Microbiomes"},{"key":"10262_CR131","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cca.2020.04.037","volume":"507","author":"W Chen","year":"2020","unstructured":"Chen W, Zhang S, Wu J, Ye T, Wang S, Wang P, Xing D (2020) Butyrate-producing bacteria and the gut-heart axis in atherosclerosis. Clin Chim Acta 507:236\u2013241. https:\/\/doi.org\/10.1016\/j.cca.2020.04.037","journal-title":"Clin Chim Acta"},{"issue":"5","key":"10262_CR132","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","volume":"11","author":"NG Frangogiannis","year":"2014","unstructured":"Frangogiannis NG (2014) The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol 11(5):255\u2013265. https:\/\/doi.org\/10.1038\/nrcardio.2014.28","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"10262_CR133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014525","volume":"6","author":"J Zhang","year":"2011","unstructured":"Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi G-P (2011) Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS ONE 6(1):e14525. https:\/\/doi.org\/10.1371\/journal.pone.0014525","journal-title":"PLoS ONE"},{"issue":"4","key":"10262_CR134","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.chom.2016.09.001","volume":"20","author":"MX Maldonado-G\u00f3mez","year":"2016","unstructured":"Maldonado-G\u00f3mez MX, Mart\u00ednez I, Bottacini F, O\u2019Callaghan A, Ventura M, van Sinderen D, Hillmann B, Vangay P, Knights D, Hutkins RW (2016) Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome. Cell Host Microbe 20(4):515\u2013526. https:\/\/doi.org\/10.1016\/j.chom.2016.09.001","journal-title":"Cell Host Microbe"},{"key":"10262_CR135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13048-018-0457-1","volume":"11","author":"M Jamilian","year":"2018","unstructured":"Jamilian M, Mansury S, Bahmani F, Heidar Z, Amirani E, Asemi Z (2018) The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome.\u00a0J Ovarian Res\u00a011:1\u20137. https:\/\/doi.org\/10.1186\/s13048-018-0457-1","journal-title":"Journal of ovarian research"},{"key":"10262_CR136","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12902-018-0248-0","volume":"18","author":"K Nasri","year":"2018","unstructured":"Nasri K, Jamilian M, Rahmani E, Bahmani F, Tajabadi-Ebrahimi M, Asemi Z (2018) The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. BMC Endocr Disord 18:1\u20138. https:\/\/doi.org\/10.1186\/s12902-018-0248-0","journal-title":"BMC Endocr Disord"},{"key":"10262_CR137","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105203","volume":"96","author":"A Arab","year":"2022","unstructured":"Arab A, Hossein-Boroujerdi M, Moini A, Sepidarkish M, Shirzad N, Karimi E (2022) Effects of probiotic supplementation on hormonal and clinical outcomes of women diagnosed with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled clinical trial.\u00a0J Funct Foods\u00a096:105203","journal-title":"Journal of Functional Foods"},{"issue":"8","key":"10262_CR138","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1007\/s00394-022-02959-z","volume":"61","author":"I Kaur","year":"2022","unstructured":"Kaur I, Suri V, Sachdeva N, Rana SV, Medhi B, Sahni N, Ahire J, Singh A (2022) Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study. Eur J Nutr 61(8):4145\u20134154","journal-title":"Eur J Nutr"},{"issue":"1","key":"10262_CR139","first-page":"1","volume":"21","author":"M Karamali","year":"2018","unstructured":"Karamali M, Eghbalpour S, Rajabi S, Jamilian M, Bahmani F, TajabadiEbrahimi M, Keneshlou F, Mirhashemi SM, Chamani M, Gelougerdi SH (2018) Effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomized, doubleblind, placebo-controlled trial. Arch Iran Med 21(1):1\u20137","journal-title":"Arch Iran Med"},{"issue":"4","key":"10262_CR140","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1017\/S0007114514004097","volume":"113","author":"CJ Hulston","year":"2015","unstructured":"Hulston CJ, Churnside AA, Venables MC (2015) Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects. Br J Nutr 113(4):596\u2013602. https:\/\/doi.org\/10.1017\/S0007114514004097","journal-title":"Br J Nutr"},{"key":"10262_CR141","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1017\/jns.2015.5","volume":"4","author":"J-i Minami","year":"2015","unstructured":"Minami J-i, Kondo S, Yanagisawa N, Odamaki T, Xiao J-Z, Abe F, Nakajima S, Hamamoto Y, Saitoh S, Shimoda T (2015) Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. Journal of Nutritional Science 4:e71.\u00a0https:\/\/doi.org\/10.1017\/jns.2015.5","journal-title":"Journal of Nutritional Science"},{"issue":"11","key":"10262_CR142","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1002\/oby.20330","volume":"21","author":"PG Cano","year":"2013","unstructured":"Cano PG, Santacruz A, Trejo FM, Sanz Y (2013) Bifidobacterium CECT 7765 improves metabolic and immunological alterations associated with obesity in high-fat diet-fed mice. Obesity 21(11):2310\u20132321. https:\/\/doi.org\/10.1002\/oby.20330","journal-title":"Obesity"},{"issue":"8","key":"10262_CR143","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1271\/bbb.100267","volume":"74","author":"S Kondo","year":"2010","unstructured":"Kondo S, Xiao J-Z, Satoh T, Odamaki T, Takahashi S, Sugahara H, Yaeshima T, Iwatsuki K, Kamei A, Abe K (2010) Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. Biosci Biotechnol Biochem 74(8):1656\u20131661. https:\/\/doi.org\/10.1271\/bbb.100267","journal-title":"Biosci Biotechnol Biochem"},{"key":"10262_CR144","doi-asserted-by":"publisher","unstructured":"Zhang J, Sun Z, Jiang S, Bai X, Ma C, Peng Q, Chen K, Chang H, Fang T, Zhang H (2019) Probiotic Bifidobacterium lactis V9 regulates the secretion of sex hormones in polycystic ovary syndrome patients through the gut-brain axis. Msystems 4(2).\u00a0https:\/\/doi.org\/10.1128\/msystems.00017-19","DOI":"10.1128\/msystems.00017-19"},{"issue":"4","key":"10262_CR145","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1080\/14647273.2017.1283446","volume":"20","author":"S Ahmadi","year":"2017","unstructured":"Ahmadi S, Jamilian M, Karamali M, Tajabadi-Ebrahimi M, Jafari P, Taghizadeh M, Memarzadeh MR, Asemi Z (2017) Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Hum Fertil 20(4):254\u2013261. https:\/\/doi.org\/10.1080\/14647273.2017.1283446","journal-title":"Hum Fertil"},{"key":"10262_CR146","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jff.2017.12.047","volume":"42","author":"N Ghanei","year":"2018","unstructured":"Ghanei N, Rezaei N, Amiri GA, Zayeri F, Makki G, Nasseri E (2018) The probiotic supplementation reduced inflammation in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.\u00a0J Funct Foods\u00a042:306\u2013311. https:\/\/doi.org\/10.1016\/j.jff.2017.12.047","journal-title":"Journal of functional foods"},{"key":"10262_CR147","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12944-020-01244-4","volume":"19","author":"E Karimi","year":"2020","unstructured":"Karimi E, Heshmati J, Shirzad N, Vesali S, Hosseinzadeh-Attar MJ, Moini A, Sepidarkish M (2020) The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial. Lipids Health Dis 19:1\u20139. https:\/\/doi.org\/10.1186\/s12944-020-01244-4","journal-title":"Lipids Health Dis"},{"issue":"4","key":"10262_CR148","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1017\/S0007114517003920","volume":"119","author":"E Karimi","year":"2018","unstructured":"Karimi E, Moini A, Yaseri M, Shirzad N, Sepidarkish M, Hossein-Boroujerdi M, Hosseinzadeh-Attar MJ (2018) Effects of synbiotic supplementation on metabolic parameters and apelin in women with polycystic ovary syndrome: a randomised double-blind placebo-controlled trial. Br J Nutr 119(4):398\u2013406. https:\/\/doi.org\/10.1017\/S0007114517003920","journal-title":"Br J Nutr"},{"key":"10262_CR149","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s12602-018-9405-z","volume":"11","author":"M Samimi","year":"2019","unstructured":"Samimi M, Dadkhah A, Haddad Kashani H, Tajabadi-Ebrahimi M, Seyed Hosseini E, Asemi Z (2019) The effects of synbiotic supplementation on metabolic status in women with polycystic ovary syndrome: a randomized double-blind clinical trial. Probiotics and antimicrobial proteins 11:1355\u20131361. https:\/\/doi.org\/10.1007\/s12602-018-9405-z","journal-title":"Probiotics and antimicrobial proteins"},{"issue":"9","key":"10262_CR150","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1210\/clinem\/dgab369","volume":"106","author":"I Chudzicka-Struga\u0142a","year":"2021","unstructured":"Chudzicka-Struga\u0142a I, Kubiak A, Banaszewska B, Zwozdziak B, Siakowska M, Pawelczyk L, Duleba AJ (2021) Effects of synbiotic supplementation and lifestyle modifications on women with polycystic ovary syndrome. J Clin Endocrinol Metab 106(9):2566\u20132573. https:\/\/doi.org\/10.1210\/clinem\/dgab369","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10262_CR151","doi-asserted-by":"publisher","first-page":"51","DOI":"10.22074\/IJFS.2021.6186","volume":"15","author":"S Darvishi","year":"2021","unstructured":"Darvishi S, Rafraf M, Asghari-Jafarabadi M, Farzadi L (2021) Synbiotic supplementation improves metabolic factors and obesity values in women with polycystic ovary syndrome independent of affecting apelin levels: a randomized double-blind placebo-controlled clinical trial. International Journal of Fertility & Sterility 15(1):51. https:\/\/doi.org\/10.22074\/IJFS.2021.6186","journal-title":"International Journal of Fertility & Sterility"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10262-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10262-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10262-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T02:10:45Z","timestamp":1727748645000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10262-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":151,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10262"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10262-y","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"13 April 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}