{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:43:18Z","timestamp":1790221398997,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32200154"],"award-info":[{"award-number":["32200154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Traditional Chinese Medicine Science and Technology Development","award":["MS2022051"],"award-info":[{"award-number":["MS2022051"]}]},{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"publisher","award":["(YKK21185).BJ23035"],"award-info":[{"award-number":["(YKK21185).BJ23035"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12602-024-10369-2","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T20:01:41Z","timestamp":1726862501000},"page":"4215-4223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of the Effectiveness of Probiotics-assisted Physical Interventions in the Management of Chronic Periodontitis: A Randomized Controlled Clinical Trial"],"prefix":"10.1007","volume":"17","author":[{"given":"Lijun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-2891","authenticated-orcid":false,"given":"Jingpeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuna","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"issue":"6","key":"10369_CR1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.tim.2020.11.004","volume":"29","author":"M Freire","year":"2021","unstructured":"Freire M, Nelson KE, Edlund A (2021) The oral host-microbial interactome: an ecological chronometer of health? Trends Microbiol 29(6):551\u2013561. https:\/\/doi.org\/10.1016\/j.tim.2020.11.004","journal-title":"Trends Microbiol"},{"issue":"1","key":"10369_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s40168-021-01056-3","volume":"9","author":"K Altabtbaei","year":"2021","unstructured":"Altabtbaei K, Maney P, Ganesan SM, Dabdoub SM, Nagaraja HN, Kumar PS (2021) Anna Karenina and the subgingival microbiome associated with periodontitis. Microbiome 9(1):97. https:\/\/doi.org\/10.1186\/s40168-021-01056-3","journal-title":"Microbiome"},{"issue":"1","key":"10369_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1600-0757.2012.00450.x","volume":"62","author":"PM Bartold","year":"2000","unstructured":"Bartold PM, Van Dyke TE (2000) Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts Periodontol 62(1):203\u2013217. https:\/\/doi.org\/10.1111\/j.1600-0757.2012.00450.x","journal-title":"Unlearning learned concepts Periodontol"},{"issue":"4","key":"10369_CR4","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1093\/femsre\/fuaa015","volume":"44","author":"F De Filippis","year":"2020","unstructured":"De Filippis F, Pasolli E, Ercolini D (2020) The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health. FEMS Microbiol Rev 44(4):454\u2013489. https:\/\/doi.org\/10.1093\/femsre\/fuaa015","journal-title":"FEMS Microbiol Rev"},{"key":"10369_CR5","doi-asserted-by":"publisher","first-page":"105174","DOI":"10.1016\/j.archoralbio.2021.105174","volume":"128","author":"GC Vale","year":"2021","unstructured":"Vale GC, Mayer MPA (2021) Effect of probiotic Lactobacillus rhamnosus by-products on gingival epithelial cells challenged with Porphyromonas gingivalis. Arch Oral Biol 128:105174. https:\/\/doi.org\/10.1016\/j.archoralbio.2021.105174","journal-title":"Arch Oral Biol"},{"issue":"6","key":"10369_CR6","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.3390\/nu13061908","volume":"13","author":"A Tremblay","year":"2021","unstructured":"Tremblay A, Xu X, Colee J, Tompkins TA (2021) Efficacy of a multi-strain probiotic formulation in pediatric populations: a comprehensive review of clinical studies. Nutrients 13(6):1908. https:\/\/doi.org\/10.3390\/nu13061908","journal-title":"Nutrients"},{"issue":"2","key":"10369_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/ccd.ccd_135_20","volume":"12","author":"AA Jebin","year":"2021","unstructured":"Jebin AA, Nisha KJ, Padmanabhan S (2021) Oral microbial shift following 1-month supplementation of probiotic chewable tablets containing Lactobacillus reuteri UBLRu-87 as an adjunct to phase 1 periodontal therapy in chronic periodontitis patients: a randomized controlled clinical trial. Contemp Clin Dent 12(2):121\u2013127. https:\/\/doi.org\/10.4103\/ccd.ccd_135_20","journal-title":"Contemp Clin Dent"},{"issue":"1","key":"10369_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/JPER.21-0078","volume":"93","author":"AM de Oliveira","year":"2022","unstructured":"de Oliveira AM, Louren\u00e7o TGB, Colombo APV (2022) Impact of systemic probiotics as adjuncts to subgingival instrumentation on the oral-gut microbiota associated with periodontitis: a randomized controlled clinical trial. J Periodontol 93(1):31\u201344. https:\/\/doi.org\/10.1002\/JPER.21-0078","journal-title":"J Periodontol"},{"key":"10369_CR9","doi-asserted-by":"publisher","unstructured":"Rui W, Zhong S, Li X, Tang X, Wang L, Yang J (2024) Evaluating the role of postbiotics in the modulation of human oral microbiota: a randomized controlled clinical trial. Probiotics Antimicrob Proteins Mar 19. https:\/\/doi.org\/10.1007\/s12602-024-10238-y","DOI":"10.1007\/s12602-024-10238-y"},{"issue":"1","key":"10369_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","volume":"6","author":"NA Bokulich","year":"2018","unstructured":"Bokulich NA, Kaehler BD, Rideout JR, Dillon M, Bolyen E, Knight R, Huttley GA, Gregory Caporaso J (2018) Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2\u2019s q2-feature-classifier plugin. Microbiome 6(1):90. https:\/\/doi.org\/10.1186\/s40168-018-0470-z","journal-title":"Microbiome"},{"issue":"21","key":"10369_CR11","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","volume":"27","author":"T Mago\u010d","year":"2011","unstructured":"Mago\u010d T, Salzberg SL (2011) FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics 27(21):2957\u20132963. https:\/\/doi.org\/10.1093\/bioinformatics\/btr507","journal-title":"Bioinformatics"},{"issue":"7","key":"10369_CR12","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","volume":"13","author":"BJ Callahan","year":"2016","unstructured":"Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP (2016) DADA2: High-resolution sample inference from Illumina amplicon data. Nat Methods 13(7):581\u2013583. https:\/\/doi.org\/10.1038\/nmeth.3869","journal-title":"Nat Methods"},{"issue":"14","key":"10369_CR13","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1093\/nar\/gkf436","volume":"30","author":"K Katoh","year":"2002","unstructured":"Katoh K, Misawa K, Kuma K, Miyata T (2002) MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res 30(14):3059\u20133066. https:\/\/doi.org\/10.1093\/nar\/gkf436","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10369_CR14","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1093\/molbev\/msp077","volume":"26","author":"MN Price","year":"2009","unstructured":"Price MN, Dehal PS, Arkin AP (2009) FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Mol Biol Evol 26(7):1641\u20131650. https:\/\/doi.org\/10.1093\/molbev\/msp077","journal-title":"Mol Biol Evol"},{"issue":"3","key":"10369_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/j.1538-7305.1948.tb01338.x","volume":"27","author":"CE Shannon","year":"1948","unstructured":"Shannon CE (1948) A mathematical theory of communication. The Bell system technical journal 27(3):379\u2013423","journal-title":"The Bell system technical journal"},{"issue":"4","key":"10369_CR16","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2307\/1942268","volume":"27","author":"JR Bray","year":"1957","unstructured":"Bray JR, Curtis JT (1957) An ordination of the upland forest communities of southern Wisconsin. Ecol Monogr 27(4):326\u2013349","journal-title":"Ecol Monogr"},{"issue":"49","key":"10369_CR17","doi-asserted-by":"publisher","first-page":"E7996","DOI":"10.1073\/pnas.1616564113","volume":"113","author":"R Zgadzaj","year":"2016","unstructured":"Zgadzaj R, Garrido-Oter R, Jensen DB, Koprivova A, Schulze-Lefert P, Radutoiu S (2016) Root nodule symbiosis in Lotus japonicus drives the establishment of distinctive rhizosphere, root, and nodule bacterial communities. Proc Natl Acad Sci U S A 113(49):E7996\u2013E8005. https:\/\/doi.org\/10.1073\/pnas.1616564113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10369_CR18","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C (2011) Metagenomic biomarker discovery and explanation. Genome Biol 12(6):R60. https:\/\/doi.org\/10.1186\/gb-2011-12-6-r60","journal-title":"Genome Biol"},{"issue":"1","key":"10369_CR19","doi-asserted-by":"publisher","first-page":"fuab039","DOI":"10.1093\/femsre\/fuab039","volume":"46","author":"A Barbour","year":"2022","unstructured":"Barbour A, Elebyary O, Fine N, Oveisi M, Glogauer M (2022) Metabolites of the oral microbiome: important mediators of multikingdom interactions. FEMS Microbiol Rev 46(1):fuab039. https:\/\/doi.org\/10.1093\/femsre\/fuab039","journal-title":"FEMS Microbiol Rev"},{"issue":"10","key":"10369_CR20","doi-asserted-by":"publisher","first-page":"4670","DOI":"10.1039\/d1fo00409c","volume":"12","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Xu W, Xu X, Lu W, Zhao J, Zhang H, Chen W (2021) Effects of Limosilactobacillus fermentum CCFM1139 on experimental periodontitis in rats. Food Funct 12(10):4670\u20134678. https:\/\/doi.org\/10.1039\/d1fo00409c","journal-title":"Food Funct"},{"issue":"5","key":"10369_CR21","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.3168\/jds.2020-19625","volume":"104","author":"Y Choi","year":"2021","unstructured":"Choi Y, Park E, Kim S, Ha J, Oh H, Kim Y, Lee Y, Seo Y, Kang J, Lee S, Lee H, Yoon Y, Choi KH (2021) Fermented milk with Lactobacillus curvatus SMFM2016-NK alleviates periodontal and gut inflammation, and alters oral and gut microbiota. J Dairy Sci 104(5):5197\u20135207. https:\/\/doi.org\/10.3168\/jds.2020-19625","journal-title":"J Dairy Sci"},{"issue":"7","key":"10369_CR22","doi-asserted-by":"publisher","first-page":"793","DOI":"10.3390\/antibiotics10070793","volume":"10","author":"A Sta\u0161kov\u00e1","year":"2021","unstructured":"Sta\u0161kov\u00e1 A, Sondorov\u00e1 M, Nemcov\u00e1 R, Ka\u010d\u00edrov\u00e1 J, Ma\u010far M (2021) Antimicrobial and antibiofilm activity of the probiotic strain Streptococcus salivarius K12 against oral potential pathogens. Antibiotics (Basel) 10(7):793. https:\/\/doi.org\/10.3390\/antibiotics10070793","journal-title":"Antibiotics (Basel)"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10369-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10369-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10369-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:43:46Z","timestamp":1763642626000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10369-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10369"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10369-2","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]},"assertion":[{"value":"17 September 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted with the informed consent of all participants and was approved by the Ethics Committee of Nanjing Stomatological Hospital Medical School of Nanjing University (NJSH-2023NL-069). All subjects gave their written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}