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In this study, we investigated the\u00a0effects of\n                    <jats:italic>Limosilactobacillus fermentum<\/jats:italic>\n                    (\n                    <jats:italic>L. fermentum<\/jats:italic>\n                    ) KBL674 in a mouse model of vaginal candidiasis.\n                    <jats:italic>L. fermentum<\/jats:italic>\n                    KBL674 inhibited\n                    <jats:italic>C. albicans<\/jats:italic>\n                    hyphal growth. Moreover, oral administration of\n                    <jats:italic>L. fermentum<\/jats:italic>\n                    KBL674 significantly suppressed vaginal\n                    <jats:italic>C. albicans<\/jats:italic>\n                    infection and associated symptoms, including tissue thickness and immune cell infiltration. A substantial quantity of\n                    <jats:italic>L. fermentum<\/jats:italic>\n                    KBL674 was excreted by the mice within 6\u00a0h after oral administration, indicating that most\n                    <jats:italic>L. fermentum<\/jats:italic>\n                    KBL674 did not settle within the gastrointestinal tract.\n                    <jats:italic>L. fermentum<\/jats:italic>\n                    KBL674 modulated gut microbiome diversity, increasing abundances of the\u00a0genera\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    ,\n                    <jats:italic>Eubacterium<\/jats:italic>\n                    , and\n                    <jats:italic>Faecalibaculum<\/jats:italic>\n                    and family\n                    <jats:italic>Muribaculaceae<\/jats:italic>\n                    . Abundances of these bacteria showed negative correlations with the vaginal\n                    <jats:italic>C. albicans<\/jats:italic>\n                    burden in the mouse model, suggesting links between the gut microbiome composition and the vaginal\n                    <jats:italic>C. albicans<\/jats:italic>\n                    burden\n                    <jats:italic>.<\/jats:italic>\n                    Therefore,\n                    <jats:italic>L. fermentum<\/jats:italic>\n                    KBL674 can reduce the vaginal\n                    <jats:italic>C. albicans<\/jats:italic>\n                    burden via direct or indirect inhibition and modulation of the gut microbiome composition preventively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s12602-024-10403-3","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T13:33:43Z","timestamp":1732023223000},"page":"4580-4589","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis"],"prefix":"10.1007","volume":"17","author":[{"given":"Sung Jae","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheonghoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ram","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jeong","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Soo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanhee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungjin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SungJun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GwangPyo","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"issue":"9577","key":"10403_CR1","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1016\/S0140-6736(07)60917-9","volume":"369","author":"JD Sobel","year":"2017","unstructured":"Sobel JD (2017) Vulvovaginal candidosis. 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