{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:00:51Z","timestamp":1788217251376,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12602-024-10425-x","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T02:20:35Z","timestamp":1735179635000},"page":"4891-4910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intestinal Goblet Cell-Expressed Reg4 Ameliorates Intestinal Inflammation Potentially by Restraining Pathogenic Escherichia coli Infection"],"prefix":"10.1007","volume":"17","author":[{"given":"Ying","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"issue":"313\u2013321","key":"10425_CR1","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1053\/j.gastro.2016.10.020","volume":"152","author":"GG Kaplan","year":"2017","unstructured":"Kaplan GG, Ng SC (2017) Understanding and preventing the global increase of inflammatory bowel disease. Gastroenterology 152(313\u2013321):e2. https:\/\/doi.org\/10.1053\/j.gastro.2016.10.020","journal-title":"Gastroenterology"},{"key":"10425_CR2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41575-020-0331-7","volume":"17","author":"MR Kudelka","year":"2020","unstructured":"Kudelka MR, Stowell SR, Cummings RD, Neish AS (2020) Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD. Nat Rev Gastroenterol Hepatol 17:597\u2013617. https:\/\/doi.org\/10.1038\/s41575-020-0331-7","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10425_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrgastro.2018.15","volume":"15","author":"A Lavelle","year":"2018","unstructured":"Lavelle A, Sokol H (2018) Gut microbiota: beyond metagenomics, metatranscriptomics illuminates microbiome functionality in IBD. Nat Rev Gastroenterol Hepatol 15:193\u2013194. https:\/\/doi.org\/10.1038\/nrgastro.2018.15","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10425_CR4","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","volume":"569","author":"J Lloyd-Price","year":"2019","unstructured":"Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW et al (2019) Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature 569:655\u2013662. https:\/\/doi.org\/10.1038\/s41586-019-1237-9","journal-title":"Nature"},{"key":"10425_CR5","doi-asserted-by":"publisher","first-page":"e132","DOI":"10.1038\/ctg.2017.58","volume":"9","author":"A Moustafa","year":"2018","unstructured":"Moustafa A, Li W, Anderson EL, Wong EHM, Dulai PS, Sandborn WJ et al (2018) Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease. Clin Transl Gastroenterol 9:e132. https:\/\/doi.org\/10.1038\/ctg.2017.58","journal-title":"Clin Transl Gastroenterol"},{"key":"10425_CR6","doi-asserted-by":"publisher","first-page":"2143218","DOI":"10.1080\/19490976.2022.2143218","volume":"14","author":"M Baumgartner","year":"2022","unstructured":"Baumgartner M, Zirnbauer R, Schlager S, Mertens D, Gasche N, Sladek B et al (2022) Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis. Gut Microbes. 14:2143218. https:\/\/doi.org\/10.1080\/19490976.2022.2143218","journal-title":"Gut Microbes."},{"key":"10425_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","volume":"63","author":"ME Johansson","year":"2014","unstructured":"Johansson ME, Gustafsson JK, Holmen-Larsson J, Jabbar KS, Xia L, Xu H et al (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63:281\u2013291. https:\/\/doi.org\/10.1136\/gutjnl-2012-303207","journal-title":"Gut"},{"key":"10425_CR8","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/S0140-6736(17)30317-3","volume":"389","author":"S Kugathasan","year":"2017","unstructured":"Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M et al (2017) Prediction of complicated disease course for children newly diagnosed with Crohn\u2019s disease: a multicentre inception cohort study. Lancet 389:1710\u20131718. https:\/\/doi.org\/10.1016\/S0140-6736(17)30317-3","journal-title":"Lancet"},{"key":"10425_CR9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.chom.2017.07.011","volume":"22","author":"JD Lewis","year":"2017","unstructured":"Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D et al (2017) Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn\u2019s disease. Cell Host Microbe 22:247. https:\/\/doi.org\/10.1016\/j.chom.2017.07.011","journal-title":"Cell Host Microbe"},{"key":"10425_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1053\/j.gastro.2004.03.054","volume":"127","author":"HM Martin","year":"2004","unstructured":"Martin HM, Campbell BJ, Hart CA, Mpofu C, Nayar M, Singh R et al (2004) Enhanced Escherichia coli adherence and invasion in Crohn\u2019s disease and colon cancer. Gastroenterology 127:80\u201393. https:\/\/doi.org\/10.1053\/j.gastro.2004.03.054","journal-title":"Gastroenterology"},{"key":"10425_CR11","doi-asserted-by":"publisher","first-page":"e1002414","DOI":"10.1371\/journal.ppat.1002414","volume":"7","author":"MH Ruchaud-Sparagano","year":"2011","unstructured":"Ruchaud-Sparagano MH, Muhlen S, Dean P, Kenny B (2011) The enteropathogenic E. coli (EPEC) Tir effector inhibits NF-kappaB activity by targeting TNFalpha receptor-associated factors. PLoS Pathog. 7:e1002414. https:\/\/doi.org\/10.1371\/journal.ppat.1002414","journal-title":"PLoS Pathog."},{"issue":"3","key":"10425_CR12","doi-asserted-by":"publisher","first-page":"e00619","DOI":"10.1128\/IAI.00619-20","volume":"89","author":"VE Watson","year":"2021","unstructured":"Watson VE, Hazen TH, Rasko DA, Jacob ME, Elfenbein JR, Stauffer SH, Gookin JL (2021) Comparative genomics of atypical enteropathogenic Escherichia coli from kittens and children identifies bacterial factors associated with virulence in kittens. Infect Immun 89(3):e00619-e620. https:\/\/doi.org\/10.1128\/IAI.00619-20","journal-title":"Infect Immun"},{"key":"10425_CR13","doi-asserted-by":"publisher","first-page":"e1003141","DOI":"10.1371\/journal.ppat.1003141","volume":"9","author":"N Dreux","year":"2013","unstructured":"Dreux N, Denizot J, Martinez-Medina M, Mellmann A, Billig M, Kisiela D et al (2013) Point mutations in FimH adhesin of Crohn\u2019s disease-associated adherent-invasive Escherichia coli enhance intestinal inflammatory response. PLoS Pathog 9:e1003141. https:\/\/doi.org\/10.1371\/journal.ppat.1003141","journal-title":"PLoS Pathog"},{"key":"10425_CR14","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.1128\/IAI.69.9.5529-5537.2001","volume":"69","author":"AL Glasser","year":"2001","unstructured":"Glasser AL, Boudeau J, Barnich N, Perruchot MH, Colombel JF, Darfeuille-Michaud A (2001) Adherent invasive Escherichia coli strains from patients with Crohn\u2019s disease survive and replicate within macrophages without inducing host cell death. Infect Immun 69:5529\u20135537. https:\/\/doi.org\/10.1128\/IAI.69.9.5529-5537.2001","journal-title":"Infect Immun"},{"key":"10425_CR15","doi-asserted-by":"publisher","unstructured":"Hartland EL, Leong JM (2013) Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution. Front Cell Infect Microbiol. 30:3:15. https:\/\/doi.org\/10.3389\/fcimb.2013.00015","DOI":"10.3389\/fcimb.2013.00015"},{"issue":"5","key":"10425_CR16","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/QCO.0b013e32834a8b8b","volume":"24","author":"TJ Ochoa","year":"2011","unstructured":"Ochoa TJ, Contreras CA (2011) Enteropathogenic E. coli (EPEC) infection in children. Curr Opin Infect Dis. 24(5):478\u201383. https:\/\/doi.org\/10.1097\/QCO.0b013e32834a8b8b","journal-title":"Curr Opin Infect Dis."},{"key":"10425_CR17","doi-asserted-by":"publisher","unstructured":"Mohammad A. Islam M. Badrul A et al. (2019) Fecal colonization with multidrug-resistant E. coli among healthy infants in rural Bangladesh, Front Microbiol. 2:10:640. https:\/\/doi.org\/10.3389\/fmicb.2019.00640","DOI":"10.3389\/fmicb.2019.00640"},{"key":"10425_CR18","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature10863","volume":"483","author":"JR McDole","year":"2012","unstructured":"McDole JR, Wheeler LW, McDonald KG, Wang B, Konjufca V, Knoop KA et al (2012) Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483:345\u2013349. https:\/\/doi.org\/10.1038\/nature10863","journal-title":"Nature"},{"key":"10425_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/77783","volume":"1","author":"T Ayabe","year":"2000","unstructured":"Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1:113\u2013118. https:\/\/doi.org\/10.1038\/77783","journal-title":"Nat Immunol"},{"key":"10425_CR20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/s0167-4781(00)00284-0","volume":"1518","author":"JC Hartupee","year":"2001","unstructured":"Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (2001) Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim Biophys Acta 1518:287\u2013293. https:\/\/doi.org\/10.1016\/s0167-4781(00)00284-0","journal-title":"Biochim Biophys Acta"},{"key":"10425_CR21","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.jmb.2010.07.061","volume":"402","author":"MR Ho","year":"2010","unstructured":"Ho MR, Lou YC, Wei SY, Luo SC, Lin WC, Lyu PC, Chen C (2010) Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. J Mol Biol 402:682\u2013695. https:\/\/doi.org\/10.1016\/j.jmb.2010.07.061","journal-title":"J Mol Biol"},{"key":"10425_CR22","doi-asserted-by":"publisher","first-page":"109310","DOI":"10.1016\/j.intimp.2022.109310","volume":"113","author":"W Wang","year":"2022","unstructured":"Wang W, Wang Y, Lu Y, Zhu J, Tian X, Wu B et al (2022) Reg4 protects against Salmonella infection-associated intestinal inflammation via adopting a calcium-dependent lectin-like domain. Int Immunopharmacol 113:109310. https:\/\/doi.org\/10.1016\/j.intimp.2022.109310","journal-title":"Int Immunopharmacol"},{"key":"10425_CR23","doi-asserted-by":"publisher","first-page":"e0390523","DOI":"10.1128\/spectrum.03905-23","volume":"12","author":"X Wan","year":"2024","unstructured":"Wan X, Wang W, Zhu J, Xiao Y (2024) Antibacterial peptide Reg4 ameliorates Pseudomonas aeruginosa-induced pulmonary inflammation and fibrosis. Microbiol Spectr 12:e0390523. https:\/\/doi.org\/10.1128\/spectrum.03905-23","journal-title":"Microbiol Spectr"},{"key":"10425_CR24","doi-asserted-by":"publisher","first-page":"100700","DOI":"10.1016\/j.jhepr.2023.100700","volume":"5","author":"Y Wang","year":"2023","unstructured":"Wang Y, Yan W, Lu Y, Du J, Tian X, Wu B et al (2023) Intestinal Reg4 deficiency confers susceptibility to high-fat diet-induced liver steatosis by increasing intestinal fat absorption in mice. JHEP Rep 5:100700. https:\/\/doi.org\/10.1016\/j.jhepr.2023.100700","journal-title":"JHEP Rep"},{"key":"10425_CR25","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1172\/JCI75436","volume":"124","author":"Y Haberman","year":"2014","unstructured":"Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R et al (2014) Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest 124:3617\u20133633. https:\/\/doi.org\/10.1172\/JCI75436","journal-title":"J Clin Invest"},{"key":"10425_CR26","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/s41385-018-0114-4","volume":"12","author":"Y Haberman","year":"2019","unstructured":"Haberman Y, Schirmer M, Dexheimer PJ, Karns R, Braun T, Kim MO et al (2019) Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn disease patients despite already established dysbiosis. Mucosal Immunol 12:491\u2013502. https:\/\/doi.org\/10.1038\/s41385-018-0114-4","journal-title":"Mucosal Immunol"},{"key":"10425_CR27","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1038\/ng.3936","volume":"49","author":"UM Marigorta","year":"2017","unstructured":"Marigorta UM, Denson LA, Hyams JS, Mondal K, Prince J, Walters TD et al (2017) Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn\u2019s disease. Nat Genet 49:1517\u20131521. https:\/\/doi.org\/10.1038\/ng.3936","journal-title":"Nat Genet"},{"key":"10425_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41467-018-07841-3","volume":"10","author":"Y Haberman","year":"2019","unstructured":"Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I et al (2019) Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun 10:38. https:\/\/doi.org\/10.1038\/s41467-018-07841-3","journal-title":"Nat Commun"},{"key":"10425_CR29","doi-asserted-by":"publisher","unstructured":"Pai N, Palmer NP, Silvester JA, Lee JJ, Beam AL, Fried I et al. (2019) Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease. Plos One. 14. https:\/\/doi.org\/10.1371\/journal.pone.0222952","DOI":"10.1371\/journal.pone.0222952"},{"issue":"10","key":"10425_CR30","doi-asserted-by":"publisher","first-page":"e0139985","DOI":"10.1371\/journal.pone.0139985","volume":"10","author":"D Wong","year":"2015","unstructured":"Wong D, Lima-J\u00fanior R, Carvalho C, Borges VF, Wanderley C, Bem A et al (2015) The adaptor protein Myd88 is a key signaling molecule in the pathogenesis of irinotecan-induced intestinal mucositis. PLoS ONE 10(10):e0139985. https:\/\/doi.org\/10.1371\/journal.pone.0139985","journal-title":"PLoS ONE"},{"key":"10425_CR31","doi-asserted-by":"publisher","unstructured":"Ledwaba SE, Costa DVS, Bolick DT, Giallourou N, Medeiros PHQS, Swann JR et al. (2020) Enteropathogenic Escherichia coli infection induces diarrhea, intestinal damage, metabolic alterations, and increased intestinal permeability in a murine model. Front Cell Infect Microbiol. 10.https:\/\/doi.org\/10.3389\/fcimb.2020.595266","DOI":"10.3389\/fcimb.2020.595266"},{"key":"10425_CR32","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/s41419-021-03931-1","volume":"12","author":"X Tian","year":"2021","unstructured":"Tian X, Wang Y, Lu Y, Wang W, Du J, Chen S et al (2021) Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19. Cell Death Dis 12:646. https:\/\/doi.org\/10.1038\/s41419-021-03931-1","journal-title":"Cell Death Dis"},{"key":"10425_CR33","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature17406","volume":"532","author":"R Okumura","year":"2016","unstructured":"Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D et al (2016) Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532:117\u2013121. https:\/\/doi.org\/10.1038\/nature17406","journal-title":"Nature"},{"key":"10425_CR34","doi-asserted-by":"publisher","unstructured":"Minami M, Takase H, Nakamura M, Makino T (2019) Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has anti-motility and anti-biofilm activity against enteropathogenic Escherichia coli. Drug Discov Therapeut. 13(6):335\u2013342. https:\/\/doi.org\/10.5582\/ddt.2019.01087","DOI":"10.5582\/ddt.2019.01087"},{"key":"10425_CR35","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/s41564-021-00939-3","volume":"6","author":"B Malleret","year":"2021","unstructured":"Malleret B, El Sahili A, Tay MZ, Carissimo G, Ong ASM, Novera W et al (2021) Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells. Nat Microbiol 6:991\u2013999. https:\/\/doi.org\/10.1038\/s41564-021-00939-3","journal-title":"Nat Microbiol"},{"key":"10425_CR36","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1038\/s41467-020-15738-3","volume":"11","author":"JA Horstmann","year":"2020","unstructured":"Horstmann JA, Lunelli M, Cazzola H, Heidemann J, Kuhne C, Steffen P et al (2020) Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion. Nat Commun 11:2013. https:\/\/doi.org\/10.1038\/s41467-020-15738-3","journal-title":"Nat Commun"},{"key":"10425_CR37","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s42003-024-05785-7","volume":"7","author":"W Yan","year":"2024","unstructured":"Yan W, Chen S, Wang Y, You Y, Lu Y, Wang W et al (2024) Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol 7:94. https:\/\/doi.org\/10.1038\/s42003-024-05785-7","journal-title":"Commun Biol"},{"key":"10425_CR38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s41232-017-0056-3","volume":"37","author":"CC Hsu","year":"2017","unstructured":"Hsu CC, Okumura R, Takeda K (2017) Human LYPD8 protein inhibits motility of flagellated bacteria. Inflamm Regen 37:23. https:\/\/doi.org\/10.1186\/s41232-017-0056-3","journal-title":"Inflamm Regen"},{"key":"10425_CR39","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.chom.2012.07.004","volume":"12","author":"FA Carvalho","year":"2012","unstructured":"Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD et al (2012) Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe 12:139\u2013152. https:\/\/doi.org\/10.1016\/j.chom.2012.07.004","journal-title":"Cell Host Microbe"},{"key":"10425_CR40","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nature14966","volume":"525","author":"D Grun","year":"2015","unstructured":"Grun D, Lyubimova A, Kester L, Wiebrands K, Basak O, Sasaki N et al (2015) Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature 525:251\u2013255. https:\/\/doi.org\/10.1038\/nature14966","journal-title":"Nature"},{"key":"10425_CR41","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature24489","volume":"551","author":"AL Haber","year":"2017","unstructured":"Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C et al (2017) A single-cell survey of the small intestinal epithelium. Nature 551:333\u2013339. https:\/\/doi.org\/10.1038\/nature24489","journal-title":"Nature"},{"key":"10425_CR42","doi-asserted-by":"publisher","unstructured":"Nystrom EEL, Martinez-Abad B, Arike L, Birchenough GMH, Nonnecke EB, Castillo PA et al. (2021) An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function. Science. 372(6539):eabb1590. https:\/\/doi.org\/10.1126\/science.abb1590","DOI":"10.1126\/science.abb1590"},{"issue":"1333\u201345","key":"10425_CR43","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1053\/j.gastro.2009.06.044","volume":"137","author":"A Gregorieff","year":"2009","unstructured":"Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J et al (2009) The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology 137(1333\u201345):e1-3. https:\/\/doi.org\/10.1053\/j.gastro.2009.06.044","journal-title":"Gastroenterology"},{"issue":"9","key":"10425_CR44","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1089\/fpd.2019.2766","volume":"17","author":"J D\u00e1vila-Avia","year":"2020","unstructured":"D\u00e1vila-Avia J, Gil-Sol\u00eds C, Merino-Mascorro J, Garc\u00eda S, Heredia N (2020) Phenolics with bactericidal activity alter motility and biofilm formation in enterotoxigenic, enteropathogenic, and enterohemorrhagic Escherichia coli. Foodborne Pathog Dis 17(9):568\u2013575. https:\/\/doi.org\/10.1089\/fpd.2019.2766","journal-title":"Foodborne Pathog Dis"},{"key":"10425_CR45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.semcdb.2015.10.032","volume":"46","author":"B Chaban","year":"2015","unstructured":"Chaban B, Hughes HV, Beeby M (2015) The flagellum in bacterial pathogens: for motility and a whole lot more. Semin Cell Dev Biol 46:91\u2013103. https:\/\/doi.org\/10.1016\/j.semcdb.2015.10.032","journal-title":"Semin Cell Dev Biol"},{"key":"10425_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4110\/in.2017.17.1.1","volume":"17","author":"H Nagao-Kitamoto","year":"2017","unstructured":"Nagao-Kitamoto H, Kamada N (2017) Host-microbial cross-talk in inflammatory bowel disease. Immune Netw 17:1\u201312. https:\/\/doi.org\/10.4110\/in.2017.17.1.1","journal-title":"Immune Netw"},{"key":"10425_CR47","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/s0016-5085(98)70019-8","volume":"115","author":"A Darfeuille-Michaud","year":"1998","unstructured":"Darfeuille-Michaud A, Neut C, Barnich N, Lederman E, Di Martino P, Desreumaux P et al (1998) Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn\u2019s disease. Gastroenterology 115:1405\u20131413. https:\/\/doi.org\/10.1016\/s0016-5085(98)70019-8","journal-title":"Gastroenterology"},{"key":"10425_CR48","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.molimm.2017.11.020","volume":"93","author":"HJ Zhang","year":"2018","unstructured":"Zhang HJ, Xu B, Wang H, Xu B, Wang GD, Jiang MZ et al (2018) IL-17 is a protection effector against the adherent-invasive Escherichia coli in murine colitis. Mol Immunol 93:166\u2013172. https:\/\/doi.org\/10.1016\/j.molimm.2017.11.020","journal-title":"Mol Immunol"},{"key":"10425_CR49","doi-asserted-by":"publisher","first-page":"G348","DOI":"10.1152\/ajpgi.00047.2013","volume":"305","author":"AM Rodriguez-Pineiro","year":"2013","unstructured":"Rodriguez-Pineiro AM, Bergstrom JH, Ermund A, Gustafsson JK, Schutte A, Johansson ME, Hansson GC (2013) Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins. Am J Physiol Gastrointest Liver Physiol 305:G348\u2013G356. https:\/\/doi.org\/10.1152\/ajpgi.00047.2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10425_CR50","doi-asserted-by":"publisher","first-page":"E5399","DOI":"10.1073\/pnas.1607327113","volume":"113","author":"N Sasaki","year":"2016","unstructured":"Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A et al (2016) Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon. Proc Natl Acad Sci U S A 113:E5399\u2013E5407. https:\/\/doi.org\/10.1073\/pnas.1607327113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10425_CR51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41586-019-0992-y","volume":"567","author":"K Parikh","year":"2019","unstructured":"Parikh K, Antanaviciute A, Fawkner-Corbett D, Jagielowicz M, Aulicino A, Lagerholm C et al (2019) Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature 567:49\u201355. https:\/\/doi.org\/10.1038\/s41586-019-0992-y","journal-title":"Nature"},{"key":"10425_CR52","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature12729","volume":"505","author":"S Mukherjee","year":"2014","unstructured":"Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D et al (2014) Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature 505:103\u2013107. https:\/\/doi.org\/10.1038\/nature12729","journal-title":"Nature"},{"key":"10425_CR53","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fcell.2019.00235","volume":"7","author":"Z Chen","year":"2019","unstructured":"Chen Z, Downing S, Tzanakakis ES (2019) Four decades after the discovery of regenerating islet-derived (Reg) proteins: current understanding and challenges. Front Cell Dev Biol 7:235. https:\/\/doi.org\/10.3389\/fcell.2019.00235","journal-title":"Front Cell Dev Biol"},{"key":"10425_CR54","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s42003-020-01219-2","volume":"3","author":"H Qi","year":"2020","unstructured":"Qi H, Wei J, Gao Y, Yang Y, Li Y, Zhu H et al (2020) Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut. Commun Biol 3:483. https:\/\/doi.org\/10.1038\/s42003-020-01219-2","journal-title":"Commun Biol"},{"key":"10425_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jobm.201100335","volume":"53","author":"Q Duan","year":"2013","unstructured":"Duan Q, Zhou M, Zhu L, Zhu G (2013) Flagella and bacterial pathogenicity. J Basic Microbiol 53:1\u20138. https:\/\/doi.org\/10.1002\/jobm.201100335","journal-title":"J Basic Microbiol"},{"issue":"2","key":"10425_CR56","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1046\/j.1365-2958.2002.02899.x","volume":"44","author":"JA Gir\u00f3n","year":"2002","unstructured":"Gir\u00f3n JA, Torres AG, Freer E, Kaper JB (2002) The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells. Mol Microbiol 44(2):361\u2013379. https:\/\/doi.org\/10.1046\/j.1365-2958.2002.02899.x","journal-title":"Mol Microbiol"},{"issue":"10","key":"10425_CR57","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.1128\/IAI.00177-09","volume":"77","author":"SCF Sampaio","year":"2009","unstructured":"Sampaio SCF, Gomes TAT, Pichon C, Du Merle L, Guadagnini S, Abe CM et al (2009) The flagella of an atypical enteropathogenic Escherichia coli strain are required for efficient interaction with and stimulation of interleukin-8 production by enterocytes in vitro. Infect Immun 77(10):4406\u20134413. https:\/\/doi.org\/10.1128\/IAI.00177-09","journal-title":"Infect Immun"},{"key":"10425_CR58","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1086\/650203","volume":"201","author":"MA Kinnebrew","year":"2010","unstructured":"Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG (2010) Bacterial flagellin stimulates Toll-like receptor 5\u2013dependent defense against vancomycin-resistant Enterococcus infection. J Infect Dis 201:534\u2013543. https:\/\/doi.org\/10.1086\/650203","journal-title":"J Infect Dis"},{"issue":"4","key":"10425_CR59","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1128\/IAI.01001-15","volume":"84","author":"S Sampaio","year":"2016","unstructured":"Sampaio S, Luiz WB, Vieira MAM, Ferreira RC, Gomes TAT (2016) Flagellar cap protein FliD mediates adherence of atypical enteropathogenic Escherichia coli to enterocyte microvillI. Infect Immun 84(4):1112\u20131122. https:\/\/doi.org\/10.1128\/IAI.01001-15","journal-title":"Infect Immun"},{"key":"10425_CR60","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1126\/science.1209791","volume":"334","author":"S Vaishnava","year":"2011","unstructured":"Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O et al (2011) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334:255\u2013258. https:\/\/doi.org\/10.1126\/science.1209791","journal-title":"Science"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10425-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10425-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10425-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:44:07Z","timestamp":1763642647000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10425-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10425"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10425-x","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"5 December 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Experiments involved in this study were approved by the Faculty of Medicine\u2019s Ethics Committee of Xin Hua Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}