{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:32:02Z","timestamp":1789792322047,"version":"4.0.1"},"reference-count":198,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s12602-024-10433-x","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T22:33:32Z","timestamp":1736894012000},"page":"2438-2460","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Gut Microbiota-Based Interventions for Parkinson\u2019s Disease: Neuroprotective Mechanisms and Current Perspective"],"prefix":"10.1007","volume":"17","author":[{"given":"Deepak","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Bishnoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanthi Kiran","family":"Kondepudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam Sunder","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"10433_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41531-023-00449-5","volume":"9","author":"Y Qu","year":"2023","unstructured":"Qu Y, Li J, Qin Q et al (2023) A systematic review and meta-analysis of inflammatory biomarkers in Parkinson\u2019s disease. NPJ Parkinsons Dis 9:18","journal-title":"NPJ Parkinsons Dis"},{"key":"10433_CR2","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","volume":"16","author":"VL Feigin","year":"2017","unstructured":"Feigin VL, Krishnamurthi RV, Theadom AM et al (2017) Global, regional, and national burden of neurological disorders during 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol 16:877\u2013897. https:\/\/doi.org\/10.1016\/S1474-4422(17)30299-5","journal-title":"Lancet Neurol"},{"key":"10433_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.20471\/may.2023.59.01.24","volume":"59","author":"S Telarovi\u0107","year":"2023","unstructured":"Telarovi\u0107 S (2023) Epidemiology of Parkinson\u2019s disease. Arch Psychiatry Res: An Int J Psychiatry Related Sci 59:147\u2013148","journal-title":"Arch Psychiatry Res: An Int J Psychiatry Related Sci"},{"key":"10433_CR4","doi-asserted-by":"publisher","first-page":"4647","DOI":"10.1039\/D2FO03379H","volume":"14","author":"J Tao","year":"2023","unstructured":"Tao J, An Y, Xu L et al (2023) The protective role of microbiota in the prevention of MPTP\/P-induced Parkinson\u2019s disease by resveratrol. Food Funct 14:4647\u20134661","journal-title":"Food Funct"},{"key":"10433_CR5","doi-asserted-by":"crossref","unstructured":"Kouli A, Torsney KM, Kuan WL (2018) Parkinson\u2019s disease: etiology, neuropathology, and pathogenesis. In: Stoker TB, Greenland JC (eds) Parkinson\u2019s disease: pathogenesis and clinical aspects [Internet]. Codon Publications,\u00a0Brisbane (AU), pp 3\u201326","DOI":"10.15586\/codonpublications.parkinsonsdisease.2018.ch1"},{"key":"10433_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s12264-022-00957-z","volume":"39","author":"R Wang","year":"2023","unstructured":"Wang R, Ren H, Kaznacheyeva E et al (2023) Association of glial activation and \u03b1-synuclein pathology in Parkinson\u2019s disease. Neurosci Bull 39:479\u2013490","journal-title":"Neurosci Bull"},{"key":"10433_CR7","doi-asserted-by":"publisher","unstructured":"Abdel-Haq R, Schlachetzki JCM, Boktor JC, et al (2022) A prebiotic diet modulates microglial states and motor deficits in \u03b1-synuclein overexpressing mice. Elife 11:. https:\/\/doi.org\/10.7554\/ELIFE.81453","DOI":"10.7554\/ELIFE.81453"},{"key":"10433_CR8","doi-asserted-by":"publisher","first-page":"937555","DOI":"10.3389\/fimmu.2022.937555","volume":"13","author":"M Zhu","year":"2022","unstructured":"Zhu M, Liu X, Ye Y et al (2022) Gut microbiota: a novel therapeutic target for Parkinson\u2019s disease. Front Immunol 13:937555","journal-title":"Front Immunol"},{"key":"10433_CR9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3390\/microbiolres15020033","volume":"15","author":"A Philip Mani","year":"2024","unstructured":"Philip Mani A, Balasubramanian B, Mali LA et al (2024) The role of the gut microbiota in neurodegenerative diseases. Microbiol Res (Pavia) 15:489\u2013507","journal-title":"Microbiol Res (Pavia)"},{"key":"10433_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.parkreldis.2017.02.002","volume":"38","author":"A Parashar","year":"2017","unstructured":"Parashar A, Udayabanu M (2017) Gut microbiota: Implications in Parkinson\u2019s disease. Parkinsonism Relat Disord 38:1\u20137","journal-title":"Parkinsonism Relat Disord"},{"key":"10433_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuroscience.2023.02.014","volume":"518","author":"N Molinero","year":"2023","unstructured":"Molinero N, Ant\u00f3n-Fern\u00e1ndez A, Hern\u00e1ndez F et al (2023) Gut microbiota, an additional hallmark of human aging and neurodegeneration. Neuroscience 518:141\u2013161","journal-title":"Neuroscience"},{"key":"10433_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.parkreldis.2016.03.012","volume":"27","author":"VD Felice","year":"2016","unstructured":"Felice VD, Quigley EM, Sullivan AM et al (2016) Microbiota-gut-brain signalling in Parkinson\u2019s disease: implications for non-motor symptoms. Parkinsonism Relat Disord 27:1\u20138","journal-title":"Parkinsonism Relat Disord"},{"key":"10433_CR13","doi-asserted-by":"publisher","first-page":"101834","DOI":"10.1016\/j.arr.2022.101834","volume":"84","author":"ABRL Silva","year":"2023","unstructured":"Silva ABRL, de Oliveira RWG, Di\u00f3genes GP et al (2023) Premotor, nonmotor and motor symptoms of Parkinson\u2019s disease: a new clinical state of the art. Ageing Res Rev 84:101834","journal-title":"Ageing Res Rev"},{"key":"10433_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bbi.2021.07.026","volume":"98","author":"V Leta","year":"2021","unstructured":"Leta V, Chaudhuri KR, Milner O et al (2021) Neurogenic and anti-inflammatory effects of probiotics in Parkinson\u2019s disease: a systematic review of preclinical and clinical evidence. Brain Behav Immun 98:59\u201373","journal-title":"Brain Behav Immun"},{"key":"10433_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13099-023-00536-1","volume":"15","author":"JM Park","year":"2023","unstructured":"Park JM, Lee SC, Ham C, Kim YW (2023) Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson\u2019s disease: a meta-analysis of randomized controlled trials. Gut Pathog 15:1\u201317","journal-title":"Gut Pathog"},{"key":"10433_CR16","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/ana.25364","volume":"84","author":"AJ Espay","year":"2018","unstructured":"Espay AJ, Morgante F, Merola A et al (2018) Levodopa-induced dyskinesia in Parkinson disease: current and evolving concepts. Ann Neurol 84:797\u2013811","journal-title":"Ann Neurol"},{"key":"10433_CR17","doi-asserted-by":"crossref","unstructured":"Rakshit D, Nayak S, Kundu S et al (2023) The pharmacological activity of garlic (Allium sativum) in Parkinson\u2019s disease: from molecular mechanisms to the therapeutic potential. ACS Chem Neurosci 14:1033\u20131044","DOI":"10.1021\/acschemneuro.2c00789"},{"key":"10433_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1017\/cjn.2023.8","volume":"51","author":"S Sarkar","year":"2024","unstructured":"Sarkar S, Roy A, Choudhury S et al (2024) Levodopa-induced dyskinesia in Parkinson\u2019s disease: plausible inflammatory and oxidative stress biomarkers. Can J Neurol Sci 51:104\u2013109","journal-title":"Can J Neurol Sci"},{"key":"10433_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40801-015-0008-7","volume":"2","author":"A Bitner","year":"2015","unstructured":"Bitner A, Zalewski P, Klawe JJ, Newton JL (2015) Drug interactions in Parkinson\u2019s disease: safety of pharmacotherapy for arterial hypertension. Drugs-Real World Outcomes 2:1\u201312","journal-title":"Drugs-Real World Outcomes"},{"key":"10433_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3109\/10401239709147768","volume":"9","author":"JL Ritter","year":"1997","unstructured":"Ritter JL, Alexander B (1997) Retrospective study of selegiline\u2013antidepressant drug interactions and a review of the literature. Ann Clin Psychiatry 9:7\u201313","journal-title":"Ann Clin Psychiatry"},{"key":"10433_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/YCO.0000000000000758","volume":"35","author":"K Berding","year":"2022","unstructured":"Berding K, Cryan JF (2022) Microbiota-targeted interventions for mental health. Curr Opin Psychiatry 35:3\u20139","journal-title":"Curr Opin Psychiatry"},{"key":"10433_CR22","doi-asserted-by":"publisher","unstructured":"Yang J, Deng Y, Cai Y et al (2022) Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: a bibliometric analysis of global research (2002\u20132022). Front Neurosci 16:. https:\/\/doi.org\/10.3389\/fnins.2022.1048565","DOI":"10.3389\/fnins.2022.1048565"},{"key":"10433_CR23","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/nutrit\/nuv019","volume":"73","author":"J Bienenstock","year":"2015","unstructured":"Bienenstock J, Kunze W, Forsythe P (2015) Microbiota and the gut\u2013brain axis. Nutr Rev 73:28\u201331","journal-title":"Nutr Rev"},{"key":"10433_CR24","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.3390\/nu15061496","volume":"15","author":"G Marano","year":"2023","unstructured":"Marano G, Mazza M, Lisci FM et al (2023) The microbiota\u2013gut\u2013brain axis: psychoneuroimmunological insights. Nutrients 15:1496","journal-title":"Nutrients"},{"key":"10433_CR25","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","volume":"19","author":"LH Morais","year":"2021","unstructured":"Morais LH, Schreiber HL IV, Mazmanian SK (2021) The gut microbiota\u2013brain axis in behaviour and brain disorders. Nat Rev Microbiol 19:241\u2013255","journal-title":"Nat Rev Microbiol"},{"key":"10433_CR26","unstructured":"Dinan TG, Cryan JF (2017) Gut feelings on Parkinson's and Depression. In: Cerebrum: the Dana forum on brain science, vol 2017.\u00a0cer-04-17"},{"key":"10433_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12640-023-00681-0","volume":"42","author":"F Villavicencio-Tejo","year":"2024","unstructured":"Villavicencio-Tejo F, Olesen MA, Navarro L et al (2024) Gut-brain axis deregulation and its possible contribution to neurodegenerative disorders. Neurotox Res 42:1\u201320","journal-title":"Neurotox Res"},{"key":"10433_CR28","doi-asserted-by":"publisher","first-page":"e2316579120","DOI":"10.1073\/pnas.2316579120","volume":"120","author":"SE Winter","year":"2023","unstructured":"Winter SE, B\u00e4umler AJ (2023) Gut dysbiosis: ecological causes and causative effects on human disease. Proc Natl Acad Sci 120:e2316579120","journal-title":"Proc Natl Acad Sci"},{"key":"10433_CR29","first-page":"1","volume":"13","author":"A Megur","year":"2021","unstructured":"Megur A, Baltriukien\u0117 D, Bukelskien\u0117 V, Burokas A (2021) The microbiota\u2013gut\u2013brain axis and Alzheimer\u2019s disease: neuroinflammation is to blame? Nutrients 13:1\u201324","journal-title":"Nutrients"},{"key":"10433_CR30","doi-asserted-by":"publisher","unstructured":"Cryan JF, O KJ, M Cowan CS, et al (2019) The microbiota-gut-brain axis. Physiol Rev 99:1877\u20132013. https:\/\/doi.org\/10.1152\/physrev.00018.2018.-The","DOI":"10.1152\/physrev.00018.2018.-The"},{"key":"10433_CR31","doi-asserted-by":"publisher","first-page":"8460","DOI":"10.3390\/ijms24108460","volume":"24","author":"D Lana","year":"2023","unstructured":"Lana D, Giovannini MG (2023) The microbiota\u2013gut\u2013brain axis in behaviour and brain disorders. Int J Mol Sci 24:8460","journal-title":"Int J Mol Sci"},{"key":"10433_CR32","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/cns.13990","volume":"29","author":"Z Li","year":"2023","unstructured":"Li Z, Liang H, Hu Y et al (2023) Gut bacterial profiles in Parkinson\u2019s disease: a systematic review. CNS Neurosci Ther 29:140\u2013157. https:\/\/doi.org\/10.1111\/cns.13990","journal-title":"CNS Neurosci Ther"},{"key":"10433_CR33","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1007\/s10571-023-01319-7","volume":"43","author":"B Aktas","year":"2023","unstructured":"Aktas B (2023) Gut microbial alteration in MPTP mouse model of Parkinson disease is administration regimen dependent. Cell Mol Neurobiol 43:2815\u20132829. https:\/\/doi.org\/10.1007\/s10571-023-01319-7","journal-title":"Cell Mol Neurobiol"},{"key":"10433_CR34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbi.2020.07.036","volume":"90","author":"J-F Liao","year":"2020","unstructured":"Liao J-F, Cheng Y-F, You S-T et al (2020) Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse models of Parkinson\u2019s disease. Brain Behav Immun 90:26\u201346","journal-title":"Brain Behav Immun"},{"key":"10433_CR35","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.14336\/AD.2023.0309","volume":"14","author":"Z Xie","year":"2023","unstructured":"Xie Z, Zhang M, Luo Y et al (2023) Healthy human fecal microbiota transplantation into mice attenuates MPTP-induced neurotoxicity via AMPK\/SOD2 pathway. Aging Dis 14:2193","journal-title":"Aging Dis"},{"key":"10433_CR36","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00702-023-02633-6","volume":"130","author":"P Borghammer","year":"2023","unstructured":"Borghammer P (2023) The brain-first vs. body-first model of Parkinson\u2019s disease with comparison to alternative models. J Neural Transm 130:737\u2013753. https:\/\/doi.org\/10.1007\/s00702-023-02633-6","journal-title":"J Neural Transm"},{"key":"10433_CR37","doi-asserted-by":"publisher","first-page":"7272","DOI":"10.1523\/JNEUROSCI.0837-06.2006","volume":"26","author":"JM Van Kampen","year":"2006","unstructured":"Van Kampen JM, Eckman CB (2006) Dopamine D3 receptor agonist delivery to a model of Parkinson\u2019s disease restores the nigrostriatal pathway and improves locomotor behavior. J Neurosci 26:7272\u20137280. https:\/\/doi.org\/10.1523\/JNEUROSCI.0837-06.2006","journal-title":"J Neurosci"},{"key":"10433_CR38","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1093\/brain\/awaa293","volume":"143","author":"NI Bohnen","year":"2020","unstructured":"Bohnen NI, Postuma RB (2020) Body-first versus brain-first biological subtyping of Parkinson\u2019s disease. Brain 143:2871\u20132873","journal-title":"Brain"},{"key":"10433_CR39","doi-asserted-by":"publisher","first-page":"S281","DOI":"10.3233\/JPD-191721","volume":"9","author":"P Borghammer","year":"2019","unstructured":"Borghammer P, Van Den Berge N (2019) Brain-first versus gut-first Parkinson\u2019s disease: a hypothesis. J Parkinsons Dis 9:S281\u2013S295","journal-title":"J Parkinsons Dis"},{"key":"10433_CR40","doi-asserted-by":"publisher","first-page":"105626","DOI":"10.1016\/j.nbd.2022.105626","volume":"164","author":"J Horsager","year":"2022","unstructured":"Horsager J, Knudsen K, Sommerauer M (2022) Clinical and imaging evidence of brain-first and body-first Parkinson\u2019s disease. Neurobiol Dis 164:105626. https:\/\/doi.org\/10.1016\/j.nbd.2022.105626","journal-title":"Neurobiol Dis"},{"key":"10433_CR41","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/0016-5085(84)90079-9","volume":"87","author":"SJ Qualman","year":"1984","unstructured":"Qualman SJ, Haupt HM, Yang P, Hamilton SR (1984) Esophageal Lewy bodies associated with ganglion cell loss in achalasia: similarity to Parkinson\u2019s disease. Gastroenterology 87:848\u2013856. https:\/\/doi.org\/10.1016\/0016-5085(84)90079-9","journal-title":"Gastroenterology"},{"key":"10433_CR42","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, R\u00fcb U et al (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211","journal-title":"Neurobiol Aging"},{"key":"10433_CR43","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.neuron.2019.05.035","volume":"103","author":"S Kim","year":"2019","unstructured":"Kim S, Kwon S-H, Kam T-I et al (2019) Transneuronal propagation of pathologic \u03b1-synuclein from the gut to the brain models Parkinson\u2019s disease. Neuron 103:627\u2013641","journal-title":"Neuron"},{"key":"10433_CR44","doi-asserted-by":"crossref","unstructured":"Pan-Montojo F, Anichtchik O, Dening Y et al (2010) Progression of Parkinson\u2019s disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One 5(1):e8762","DOI":"10.1371\/journal.pone.0008762"},{"key":"10433_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-018-0257-5","volume":"13","author":"N Uemura","year":"2018","unstructured":"Uemura N, Yagi H, Uemura MT et al (2018) Inoculation of \u03b1-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve. Mol Neurodegener 13:1\u201311","journal-title":"Mol Neurodegener"},{"key":"10433_CR46","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41593-020-0589-7","volume":"23","author":"C Challis","year":"2020","unstructured":"Challis C, Hori A, Sampson TR et al (2020) Gut-seeded \u03b1-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nat Neurosci 23:327\u2013336","journal-title":"Nat Neurosci"},{"key":"10433_CR47","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41419-022-05531-z","volume":"14","author":"Z Yang","year":"2023","unstructured":"Yang Z, Wang Y, Wei M et al (2023) Intrastriatal injection of Parkinson\u2019s disease intestine and vagus lysates initiates \u03b1-synucleinopathy in rat brain. Cell Death Dis 14:4","journal-title":"Cell Death Dis"},{"key":"10433_CR48","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/nsmb.3433","volume":"24","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Kang SS, Liu X et al (2017) Asparagine endopeptidase cleaves \u03b1-synuclein and mediates pathologic activities in Parkinson\u2019s disease. Nat Struct Mol Biol 24:632\u2013642","journal-title":"Nat Struct Mol Biol"},{"key":"10433_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41531-022-00430-8","volume":"9","author":"H Wang","year":"2023","unstructured":"Wang H, Chen G, Ahn EH et al (2023) C\/EBP\u03b2\/AEP is age-dependently activated in Parkinson\u2019s disease and mediates \u03b1-synuclein in the gut and brain. NPJ Parkinsons Dis 9:1","journal-title":"NPJ Parkinsons Dis"},{"key":"10433_CR50","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/s41380-020-0687-7","volume":"26","author":"Z Wu","year":"2021","unstructured":"Wu Z, Xia Y, Wang Z et al (2021) C\/EBP\u03b2\/\u03b4-secretase signaling mediates Parkinson\u2019s disease pathogenesis via regulating transcription and proteolytic cleavage of \u03b1-synuclein and MAOB. Mol Psychiatry 26:568\u2013585","journal-title":"Mol Psychiatry"},{"key":"10433_CR51","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41586-019-1405-y","volume":"571","author":"D Matheoud","year":"2019","unstructured":"Matheoud D, Cannon T, Voisin A et al (2019) Intestinal infection triggers Parkinson\u2019s disease-like symptoms in Pink1\u2212\/\u2212 mice. Nature 571:565\u2013569","journal-title":"Nature"},{"key":"10433_CR52","doi-asserted-by":"publisher","first-page":"34477","DOI":"10.1038\/srep34477","volume":"6","author":"SG Chen","year":"2016","unstructured":"Chen SG, Stribinskis V, Rane MJ et al (2016) Exposure to the functional bacterial amyloid protein curli enhances alpha-synuclein aggregation in aged Fischer 344 rats and Caenorhabditis elegans. Sci Rep 6:34477","journal-title":"Sci Rep"},{"key":"10433_CR53","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1002\/mds.25736","volume":"29","author":"LP Kelly","year":"2014","unstructured":"Kelly LP, Carvey PM, Keshavarzian A et al (2014) Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson\u2019s disease. Mov Disord 29:999\u20131009","journal-title":"Mov Disord"},{"key":"10433_CR54","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/s41380-022-01910-2","volume":"28","author":"EH Ahn","year":"2023","unstructured":"Ahn EH, Liu X, Alam AM et al (2023) Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson\u2019s disease. Mol Psychiatry 28:1337\u20131350","journal-title":"Mol Psychiatry"},{"key":"10433_CR55","doi-asserted-by":"crossref","unstructured":"Zhu M, Liu X, Ye Y et al (2022) Gut microbiota: a novel therapeutic target for Parkinson\u2019s disease. Front Immunol 13:937555","DOI":"10.3389\/fimmu.2022.937555"},{"key":"10433_CR56","doi-asserted-by":"publisher","first-page":"114081","DOI":"10.1016\/j.bbr.2022.114081","volume":"436","author":"D Rathour","year":"2023","unstructured":"Rathour D, Shah S, Khan S et al (2023) Role of gut microbiota in depression: understanding molecular pathways, recent research, and future direction. Behav Brain Res 436:114081","journal-title":"Behav Brain Res"},{"key":"10433_CR57","doi-asserted-by":"publisher","unstructured":"Yuan X, Chai J, Xu W, Zhao Y (2024) Exploring the potential of probiotics and prebiotics in major depression: from molecular function to clinical therapy. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10326-z","DOI":"10.1007\/s12602-024-10326-z"},{"key":"10433_CR58","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.1039\/D0FO02855J","volume":"12","author":"HN Methiwala","year":"2021","unstructured":"Methiwala HN, Vaidya B, Addanki VK et al (2021) Gut microbiota in mental health and depression: Role of pre\/pro\/synbiotics in their modulation. Food Funct 12:4284\u20134314","journal-title":"Food Funct"},{"key":"10433_CR59","doi-asserted-by":"publisher","first-page":"105691","DOI":"10.1016\/j.neuint.2024.105691","volume":"174","author":"S Valvaikar","year":"2024","unstructured":"Valvaikar S, Vaidya B, Sharma S et al (2024) Supplementation of probiotic Bifidobacterium breve Bif11 reverses neurobehavioural deficits, inflammatory changes and oxidative stress in Parkinson\u2019s disease model. Neurochem Int 174:105691","journal-title":"Neurochem Int"},{"key":"10433_CR60","doi-asserted-by":"publisher","first-page":"123326","DOI":"10.1016\/j.ijbiomac.2023.123326","volume":"231","author":"S Sharma","year":"2023","unstructured":"Sharma S, Bhatia R, Devi K et al (2023) A synbiotic combination of Bifidobacterium longum Bif10 and Bifidobacterium breve Bif11, isomaltooligosaccharides and finger millet arabinoxylan prevents dextran sodium sulphate induced ulcerative colitis in mice. Int J Biol Macromol 231:123326","journal-title":"Int J Biol Macromol"},{"key":"10433_CR61","first-page":"6378","volume":"10","author":"P Sharma","year":"2023","unstructured":"Sharma P, Das S, Sadhu P et al (2023) Therapeutic role of probiotics in managing various diseases. J Surv Fish Sci 10:6378\u20136380","journal-title":"J Surv Fish Sci"},{"key":"10433_CR62","doi-asserted-by":"publisher","unstructured":"Chakravarty K, Gaur S, Kumar R et al (2024) Exploring the multifaceted therapeutic potential of probiotics: a review of current insights and applications. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10328-x","DOI":"10.1007\/s12602-024-10328-x"},{"key":"10433_CR63","doi-asserted-by":"publisher","unstructured":"Shirkhan F, Safaei F, Mirdamadi S, Zandi M (2024) The role of probiotics in skin care: advances, challenges, and future needs. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10319-y","DOI":"10.1007\/s12602-024-10319-y"},{"key":"10433_CR64","doi-asserted-by":"publisher","unstructured":"Pujari R, Jadhav D, Angal A, et al (2024) Beneficial effect of synbiotic combination of Limosilactobacillus fermentum FS-10, Lactiplantibacillus plantarum Lp1-IC and short-chain fructooligosaccharides in colitis murine model. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10320-5","DOI":"10.1007\/s12602-024-10320-5"},{"key":"10433_CR65","doi-asserted-by":"publisher","unstructured":"Lashkarbolouk N, Mazandarani M, Pakmehr A, Ejtahed H-S (2024) Evaluating the role of probiotics, prebiotics, and synbiotics supplementation in age-related musculoskeletal disorders in older adults: a systematic review. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10306-3","DOI":"10.1007\/s12602-024-10306-3"},{"key":"10433_CR66","doi-asserted-by":"publisher","unstructured":"da Silva TF, Gl\u00f3ria R de A, Americo MF et al (2024) Unlocking the potential of probiotics: a comprehensive review on research, production, and regulation of probiotics. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10247-x","DOI":"10.1007\/s12602-024-10247-x"},{"key":"10433_CR67","doi-asserted-by":"publisher","unstructured":"Aljohani A, Rashwan N, Vasani S et al (2024) The health benefits of probiotic Lactiplantibacillus plantarum: a systematic review and meta-analysis. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10287-3","DOI":"10.1007\/s12602-024-10287-3"},{"key":"10433_CR68","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.3390\/microorganisms10081544","volume":"10","author":"S Thangaleela","year":"2022","unstructured":"Thangaleela S, Sivamaruthi BS, Kesika P et al (2022) Role of the gut\u2013brain axis, gut microbial composition, diet, and probiotic intervention in Parkinson\u2019s disease. Microorganisms 10:1544","journal-title":"Microorganisms"},{"key":"10433_CR69","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1039\/D2FO03825K","volume":"14","author":"C Chu","year":"2023","unstructured":"Chu C, Yu L, Li Y et al (2023) Meta-analysis of randomized controlled trials of the effects of probiotics in Parkinson\u2019s disease. Food Funct 14:3406\u20133422","journal-title":"Food Funct"},{"key":"10433_CR70","doi-asserted-by":"publisher","first-page":"101347","DOI":"10.1016\/j.arr.2021.101347","volume":"69","author":"S-Y Zheng","year":"2021","unstructured":"Zheng S-Y, Li H-X, Xu R-C et al (2021) Potential roles of gut microbiota and microbial metabolites in Parkinson\u2019s disease. Ageing Res Rev 69:101347","journal-title":"Ageing Res Rev"},{"key":"10433_CR71","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.ijbiomac.2020.07.180","volume":"164","author":"X-L Dong","year":"2020","unstructured":"Dong X-L, Wang X, Liu F et al (2020) Polymannuronic acid prevents dopaminergic neuronal loss via brain-gut-microbiota axis in Parkinson\u2019s disease model. Int J Biol Macromol 164:994\u20131005","journal-title":"Int J Biol Macromol"},{"key":"10433_CR72","doi-asserted-by":"publisher","unstructured":"Chu C, Yu L, Li Y et al (2023) Lactobacillus plantarum CCFM405 against rotenone-induced Parkinson\u2019s disease mice via regulating gut microbiota and branched-chain amino acids biosynthesis. Nutrients 15:. https:\/\/doi.org\/10.3390\/nu15071737","DOI":"10.3390\/nu15071737"},{"key":"10433_CR73","doi-asserted-by":"publisher","first-page":"e10455","DOI":"10.1002\/btm2.10455","volume":"8","author":"H Fan","year":"2023","unstructured":"Fan H, Sheng S, Li D et al (2023) Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome. Bioeng Transl Med 8:e10455","journal-title":"Bioeng Transl Med"},{"key":"10433_CR74","doi-asserted-by":"publisher","first-page":"6794","DOI":"10.3390\/ijms24076794","volume":"24","author":"YZ Lee","year":"2023","unstructured":"Lee YZ, Cheng S-H, Chang M-Y et al (2023) Neuroprotective effects of Lactobacillus plantarum PS128 in a mouse model of Parkinson\u2019s disease: the role of gut microbiota and MicroRNAs. Int J Mol Sci 24:6794","journal-title":"Int J Mol Sci"},{"key":"10433_CR75","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbi.2020.07.036","volume":"90","author":"JF Liao","year":"2020","unstructured":"Liao JF, Cheng YF, You ST et al (2020) Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson\u2019s disease. Brain Behav Immun 90:26\u201346. https:\/\/doi.org\/10.1016\/j.bbi.2020.07.036","journal-title":"Brain Behav Immun"},{"key":"10433_CR76","doi-asserted-by":"crossref","unstructured":"Sancandi M, De Caro C, Cypaite N et al (2023) Effects of a probiotic suspension SymproveTM on a rat early-stage Parkinson\u2019s disease model. Front Aging Neurosci 14:986127","DOI":"10.3389\/fnagi.2022.986127"},{"key":"10433_CR77","doi-asserted-by":"publisher","first-page":"e03208","DOI":"10.1128\/spectrum.03208-22","volume":"11","author":"L Zhou","year":"2023","unstructured":"Zhou L, Han D, Wang X, Chen Z (2023) Probiotic formulation VSL# 3 interacts with mesenchymal stromal cells to protect dopaminergic neurons via centrally and peripherally suppressing NOD-like receptor protein 3 inflammasome-mediated inflammation in Parkinson\u2019s disease mice. Microbiol Spectr 11:e03208-e3222","journal-title":"Microbiol Spectr"},{"key":"10433_CR78","doi-asserted-by":"publisher","first-page":"4678","DOI":"10.3390\/nu14214678","volume":"14","author":"T Li","year":"2022","unstructured":"Li T, Chu C, Yu L et al (2022) Neuroprotective effects of Bifidobacterium breve CCFM1067 in MPTP-induced mouse models of Parkinson\u2019s disease. Nutrients 14:4678","journal-title":"Nutrients"},{"key":"10433_CR79","doi-asserted-by":"publisher","first-page":"4886","DOI":"10.3390\/nu14224886","volume":"14","author":"M Yue","year":"2022","unstructured":"Yue M, Wei J, Chen W et al (2022) Neurotrophic role of the next-generation probiotic strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson\u2019s disease via inhibiting ferroptosis. Nutrients 14:4886","journal-title":"Nutrients"},{"key":"10433_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13568-020-01014-6","volume":"10","author":"X Fang","year":"2020","unstructured":"Fang X, Zhou X, Miao Y et al (2020) Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer\u2019s disease and Parkinson\u2019s disease. AMB Express 10:1\u201313","journal-title":"AMB Express"},{"key":"10433_CR81","doi-asserted-by":"publisher","unstructured":"Wang L, Li S, Jiang Y et al (2021) Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson\u2019s disease model mice. J Funct Foods 85:. https:\/\/doi.org\/10.1016\/j.jff.2021.104635","DOI":"10.1016\/j.jff.2021.104635"},{"key":"10433_CR82","doi-asserted-by":"publisher","first-page":"e10351","DOI":"10.1002\/btm2.10351","volume":"8","author":"H Wu","year":"2023","unstructured":"Wu H, Wei J, Zhao X et al (2023) Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson\u2019s disease in mice by delivering GLP-1 and modulating gut microbiota. Bioeng Transl Med 8:e10351","journal-title":"Bioeng Transl Med"},{"key":"10433_CR83","doi-asserted-by":"crossref","unstructured":"Ryu Y-K, Chang D-H, Park H-Y et al (2022) Agathobaculum butyriciproducens shows neuroprotective effects in a 6-OHDA-induced mouse model of Parkinson\u2019s disease. J Microbiol Biotechnol 32:1168","DOI":"10.4014\/jmb.2205.05032"},{"key":"10433_CR84","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.bbi.2020.10.014","volume":"91","author":"J Sun","year":"2021","unstructured":"Sun J, Li H, Jin Y et al (2021) Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson\u2019s disease via gut microbiota-GLP-1 pathway. Brain Behav Immun 91:703\u2013715","journal-title":"Brain Behav Immun"},{"key":"10433_CR85","doi-asserted-by":"crossref","unstructured":"Wang Y, Chen W, Han Y et al (2023) Neuroprotective effect of engineered Clostridium butyricum\u2010pMTL007\u2010GLP\u20101 on Parkinson\u2019s disease mice models via promoting mitophagy. Bioeng Transl Med 8:e10505","DOI":"10.1002\/btm2.10505"},{"key":"10433_CR86","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/biomedicines9020167","volume":"9","author":"T Ishii","year":"2021","unstructured":"Ishii T, Furuoka H, Kaya M, Kuhara T (2021) Oral administration of probiotic bifidobacterium breve improves facilitation of hippocampal memory extinction via restoration of aberrant higher induction of neuropsin in an MPTP-induced mouse model of Parkinson\u2019s disease. Biomedicines 9:167","journal-title":"Biomedicines"},{"key":"10433_CR87","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1080\/15321819.2020.1833917","volume":"42","author":"E Alipour Nosrani","year":"2021","unstructured":"Alipour Nosrani E, Tamtaji OR, Alibolandi Z et al (2021) Neuroprotective effects of probiotics bacteria on animal model of Parkinson\u2019s disease induced by 6-hydroxydopamine: a behavioral, biochemical, and histological study. J Immunoassay Immunochem 42:106\u2013120","journal-title":"J Immunoassay Immunochem"},{"key":"10433_CR88","doi-asserted-by":"publisher","first-page":"668775","DOI":"10.3389\/fnagi.2021.668775","volume":"13","author":"BA Nurrahma","year":"2021","unstructured":"Nurrahma BA, Tsao S-P, Wu C-H et al (2021) Probiotic supplementation facilitates recovery of 6-OHDA-induced motor deficit via improving mitochondrial function and energy metabolism. Front Aging Neurosci 13:668775","journal-title":"Front Aging Neurosci"},{"key":"10433_CR89","doi-asserted-by":"crossref","unstructured":"Ma Y-F, Lin Y-A, Huang C-L et al (2023) Lactiplantibacillus plantarum PS128 alleviates exaggerated cortical beta oscillations and motor deficits in the 6-hydroxydopamine rat model of Parkinson\u2019s disease. Probiotics Antimicrob Proteins 15:312\u2013325","DOI":"10.1007\/s12602-021-09828-x"},{"key":"10433_CR90","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.18632\/aging.102927","volume":"12","author":"V Castelli","year":"2020","unstructured":"Castelli V, d\u2019Angelo M, Lombardi F et al (2020) Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson\u2019s disease models. Aging (albany NY) 12:4641","journal-title":"Aging (albany NY)"},{"key":"10433_CR91","doi-asserted-by":"crossref","unstructured":"Vis\u00f1uk DP, de Giori GS, LeBlanc JG, de LeBlanc ADM (2020) Neuroprotective effects associated with immune modulation by selected lactic acid bacteria in a Parkinson\u2019s disease model. Nutrition 79:110995","DOI":"10.1016\/j.nut.2020.110995"},{"key":"10433_CR92","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/jnc.14694","volume":"150","author":"X Fang","year":"2019","unstructured":"Fang X, Tian P, Zhao X et al (2019) Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1. J Neurochem 150:441\u2013452. https:\/\/doi.org\/10.1111\/jnc.14694","journal-title":"J Neurochem"},{"key":"10433_CR93","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jnutbio.2019.03.021","volume":"69","author":"S Srivastav","year":"2019","unstructured":"Srivastav S, Neupane S, Bhurtel S et al (2019) Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity. J Nutr Biochem 69:73\u201386","journal-title":"J Nutr Biochem"},{"key":"10433_CR94","doi-asserted-by":"publisher","unstructured":"Aktas B, Aslim B, Ozdemir DA (2024) A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson\u2019s disease. Sci Rep 14:. https:\/\/doi.org\/10.1038\/s41598-024-65061-w","DOI":"10.1038\/s41598-024-65061-w"},{"key":"10433_CR95","doi-asserted-by":"publisher","first-page":"111067","DOI":"10.1016\/j.foodres.2022.111067","volume":"155","author":"X Liu","year":"2022","unstructured":"Liu X, Du ZR, Wang X et al (2022) Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection against Parkinson\u2019s disease. Food Res Int 155:111067","journal-title":"Food Res Int"},{"key":"10433_CR96","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jns.2017.08.3235","volume":"381","author":"J Liu","year":"2017","unstructured":"Liu J, Wang F, Liu S et al (2017) Sodium butyrate exerts protective effect against Parkinson\u2019s disease in mice via stimulation of glucagon like peptide-1. J Neurol Sci 381:176\u2013181","journal-title":"J Neurol Sci"},{"key":"10433_CR97","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3390\/nu15040930","volume":"15","author":"T-T Guo","year":"2023","unstructured":"Guo T-T, Zhang Z, Sun Y et al (2023) Neuroprotective effects of sodium butyrate by restoring gut microbiota and inhibiting TLR4 signaling in mice with MPTP-induced Parkinson\u2019s disease. Nutrients 15:930","journal-title":"Nutrients"},{"key":"10433_CR98","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.bbr.2015.05.052","volume":"291","author":"S Sharma","year":"2015","unstructured":"Sharma S, Taliyan R, Singh S (2015) Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity. Behav Brain Res 291:306\u2013314","journal-title":"Behav Brain Res"},{"key":"10433_CR99","doi-asserted-by":"publisher","first-page":"147749","DOI":"10.1016\/j.brainres.2021.147749","volume":"1776","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Xu S, Qian Y et al (2022) Sodium butyrate attenuates rotenone-induced toxicity by activation of autophagy through epigenetically regulating PGC-1\u03b1 expression in PC12 cells. Brain Res 1776:147749","journal-title":"Brain Res"},{"key":"10433_CR100","doi-asserted-by":"publisher","first-page":"1099018","DOI":"10.3389\/fnagi.2023.1099018","volume":"15","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Xu S, Qian Y et al (2023) Sodium butyrate ameliorates gut dysfunction and motor deficits in a mouse model of Parkinson\u2019s disease by regulating gut microbiota. Front Aging Neurosci 15:1099018","journal-title":"Front Aging Neurosci"},{"key":"10433_CR101","doi-asserted-by":"publisher","unstructured":"Kakoty V, K C S, Dubey SK et al (2021) Neuroprotective effects of trehalose and sodium butyrate on preformed fibrillar form of \u03b1-synuclein-induced rat model of Parkinson\u2019s disease. ACS Chem Neurosci 12:2643\u20132660. https:\/\/doi.org\/10.1021\/acschemneuro.1c00144","DOI":"10.1021\/acschemneuro.1c00144"},{"key":"10433_CR102","doi-asserted-by":"publisher","unstructured":"Hou Y fang, Shan C, Zhuang S yue et al (2021) Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson\u2019s disease. Microbiome 9:. https:\/\/doi.org\/10.1186\/s40168-020-00988-6","DOI":"10.1186\/s40168-020-00988-6"},{"key":"10433_CR103","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1007\/s11064-021-03411-0","volume":"46","author":"Z Zhong","year":"2021","unstructured":"Zhong Z, Chen W, Gao H et al (2021) Fecal microbiota transplantation exerts a protective role in MPTP-induced Parkinson\u2019s disease via the TLR4\/PI3K\/AKT\/NF-\u03baB Pathway Stimulated by \u03b1-Synuclein. Neurochem Res 46:3050\u20133058","journal-title":"Neurochem Res"},{"key":"10433_CR104","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbi.2018.02.005","volume":"70","author":"M-F Sun","year":"2018","unstructured":"Sun M-F, Zhu Y-L, Zhou Z-L et al (2018) Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson\u2019s disease mice: gut microbiota, glial reaction and TLR4\/TNF-\u03b1 signaling pathway. Brain Behav Immun 70:48\u201360. https:\/\/doi.org\/10.1016\/j.bbi.2018.02.005","journal-title":"Brain Behav Immun"},{"key":"10433_CR105","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1007\/s13311-023-01420-1","volume":"20","author":"C-M Qiao","year":"2023","unstructured":"Qiao C-M, Zhou Y, Quan W et al (2023) Fecal microbiota transplantation from aged mice render recipient mice resistant to MPTP-induced nigrostriatal degeneration via a neurogenesis-dependent but inflammation-independent manner. Neurotherapeutics 20:1405\u20131426. https:\/\/doi.org\/10.1007\/s13311-023-01420-1","journal-title":"Neurotherapeutics"},{"key":"10433_CR106","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s40168-021-01107-9","volume":"9","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Ning J, Bao X et al (2021) Fecal microbiota transplantation protects rotenone-induced Parkinson\u2019s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis. Microbiome 9:226. https:\/\/doi.org\/10.1186\/s40168-021-01107-9","journal-title":"Microbiome"},{"key":"10433_CR107","doi-asserted-by":"publisher","unstructured":"Cruz-Pereira JS, Moloney GM, Bastiaanssen TFS et al (2022) Prebiotic supplementation modulates selective effects of stress on behavior and brain metabolome in aged mice. Neurobiol Stress 21:. https:\/\/doi.org\/10.1016\/j.ynstr.2022.100501","DOI":"10.1016\/j.ynstr.2022.100501"},{"key":"10433_CR108","doi-asserted-by":"crossref","unstructured":"Megur A, Daliri EB-M, Baltriukien\u0117 D, Burokas A (2022) Prebiotics as a tool for the prevention and treatment of obesity and diabetes: classification and ability to modulate the gut microbiota. Int J Mol Sci 23:6097","DOI":"10.3390\/ijms23116097"},{"key":"10433_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-023-36497-x","volume":"14","author":"DA Hall","year":"2023","unstructured":"Hall DA, Voigt RM, Cantu-Jungles TM et al (2023) An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson\u2019s disease participants. Nat Commun 14:1\u201314","journal-title":"Nat Commun"},{"key":"10433_CR110","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.gpb.2021.08.009","volume":"20","author":"A Becker","year":"2022","unstructured":"Becker A, Schmartz GP, Gr\u00f6ger L et al (2022) Effects of resistant starch on symptoms, fecal markers, and gut microbiota in parkinson\u2019s disease\u2014the RESISTA-PD trial. Genomics Proteomics Bioinformatics 20:274\u2013287","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10433_CR111","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/1028415X.2020.1751509","volume":"25","author":"Z Paknahad","year":"2022","unstructured":"Paknahad Z, Sheklabadi E, Moravejolahkami AR et al (2022) The effects of Mediterranean diet on severity of disease and serum Total Antioxidant Capacity (TAC) in patients with Parkinson\u2019s disease: a single center, randomized controlled trial. Nutr Neurosci 25:313\u2013320. https:\/\/doi.org\/10.1080\/1028415X.2020.1751509","journal-title":"Nutr Neurosci"},{"key":"10433_CR112","doi-asserted-by":"publisher","unstructured":"Sun H, Zhao F, Liu Y et al (2022) Probiotics synergized with conventional regimen in managing Parkinson\u2019s disease. NPJ Parkinsons Dis 8:. https:\/\/doi.org\/10.1038\/s41531-022-00327-6","DOI":"10.1038\/s41531-022-00327-6"},{"key":"10433_CR113","doi-asserted-by":"publisher","first-page":"e772","DOI":"10.1212\/WNL.0000000000010998","volume":"96","author":"AH Tan","year":"2021","unstructured":"Tan AH, Lim S-Y, Chong KK et al (2021) Probiotics for constipation in Parkinson disease: a randomized placebo-controlled study. Neurology 96:e772\u2013e782","journal-title":"Neurology"},{"key":"10433_CR114","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.clnu.2018.05.018","volume":"38","author":"OR Tamtaji","year":"2019","unstructured":"Tamtaji OR, Taghizadeh M, Daneshvar Kakhaki R et al (2019) Clinical and metabolic response to probiotic administration in people with Parkinson\u2019s disease: a randomized, double-blind, placebo-controlled trial. Clin Nutr 38:1031\u20131035. https:\/\/doi.org\/10.1016\/j.clnu.2018.05.018","journal-title":"Clin Nutr"},{"key":"10433_CR115","unstructured":"Borzabadi S, Oryan S, Eidi A, Asemi Z (2018) The effects of probiotic supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson\u2019s disease: a randomized, double-blind, placebocontrolled trial. Arch Iran Med 21:289\u2013295"},{"key":"10433_CR116","doi-asserted-by":"crossref","unstructured":"Georgescu D, Ancusa OE, Georgescu LA et al (2016) Nonmotor gastrointestinal disorders in older patients with Parkinson\u2019s disease: is there hope? Clin Interv Aging 1601\u20131608","DOI":"10.2147\/CIA.S106284"},{"key":"10433_CR117","doi-asserted-by":"publisher","unstructured":"Lu CS, Chang HC, Weng YH et al (2021) The add-on effect of Lactobacillus plantarum PS128 in patients with Parkinson\u2019s disease: a pilot study. Front Nutr 8:. https:\/\/doi.org\/10.3389\/fnut.2021.650053","DOI":"10.3389\/fnut.2021.650053"},{"key":"10433_CR118","doi-asserted-by":"publisher","first-page":"105397","DOI":"10.1016\/j.jff.2022.105397","volume":"100","author":"S Mehrabani","year":"2023","unstructured":"Mehrabani S, Khorvash F, Heidari Z et al (2023) The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson\u2019s disease: a double-blind, placebo-controlled, randomized controlled trial. J Funct Foods 100:105397","journal-title":"J Funct Foods"},{"key":"10433_CR119","doi-asserted-by":"publisher","first-page":"e0244680","DOI":"10.1371\/journal.pone.0244680","volume":"15","author":"A Ibrahim","year":"2020","unstructured":"Ibrahim A, Ali RAR, Manaf MRA et al (2020) Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson\u2019s disease: a randomised controlled trial. PLoS ONE 15:e0244680","journal-title":"PLoS ONE"},{"key":"10433_CR120","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1212\/WNL.0000000000003127","volume":"87","author":"M Barichella","year":"2016","unstructured":"Barichella M, Pacchetti C, Bolliri C et al (2016) Probiotics and prebiotic fiber for constipation associated with Parkinson disease: an RCT. Neurology 87:1274\u20131280","journal-title":"Neurology"},{"key":"10433_CR121","doi-asserted-by":"publisher","unstructured":"Bruggeman A, Vandendriessche C, Hamerlinck H et al (2024) Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson\u2019s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial. EClinicalMedicine 71:. https:\/\/doi.org\/10.1016\/j.eclinm.2024.102563","DOI":"10.1016\/j.eclinm.2024.102563"},{"key":"10433_CR122","doi-asserted-by":"publisher","unstructured":"Cheng Y, Tan G, Zhu Q et al (2023) Efficacy of fecal microbiota transplantation in patients with Parkinson\u2019s disease: clinical trial results from a randomized, placebo-controlled design. Gut Microbes 15:. https:\/\/doi.org\/10.1080\/19490976.2023.2284247","DOI":"10.1080\/19490976.2023.2284247"},{"key":"10433_CR123","doi-asserted-by":"crossref","unstructured":"DuPont HL, Suescun J, Jiang ZD et al (2023) Fecal microbiota transplantation in Parkinson\u2019s disease-a randomized repeat-dose, placebo-controlled clinical pilot study. Front Neurol 14: 1104759","DOI":"10.3389\/fneur.2023.1104759"},{"key":"10433_CR124","doi-asserted-by":"publisher","unstructured":"Kuai X yi, Yao X han, Xu L juan et al (2021) Evaluation of fecal microbiota transplantation in Parkinson\u2019s disease patients with constipation. Microb Cell Fact 20:. https:\/\/doi.org\/10.1186\/s12934-021-01589-0","DOI":"10.1186\/s12934-021-01589-0"},{"key":"10433_CR125","doi-asserted-by":"publisher","first-page":"E22035","DOI":"10.1097\/MD.0000000000022035","volume":"99","author":"LJ Xue","year":"2020","unstructured":"Xue LJ, Yang XZ, Tong Q et al (2020) Fecal microbiota transplantation therapy for Parkinson\u2019s disease: a preliminary study. Medicine (United States) 99:E22035. https:\/\/doi.org\/10.1097\/MD.0000000000022035","journal-title":"Medicine (United States)"},{"key":"10433_CR126","doi-asserted-by":"publisher","unstructured":"Sergeev IN, Aljutaily T, Walton G, Huarte E (2020) Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients 12:. https:\/\/doi.org\/10.3390\/nu12010222","DOI":"10.3390\/nu12010222"},{"key":"10433_CR127","doi-asserted-by":"crossref","unstructured":"Balasubramanian R, Schneider E, Gunnigle E et al (2024) Fermented foods: harnessing their potential to modulate the microbiota-gut-brain axis for mental health. Neurosci Biobehav Rev 105562","DOI":"10.1016\/j.neubiorev.2024.105562"},{"key":"10433_CR128","doi-asserted-by":"publisher","first-page":"109502","DOI":"10.1016\/j.foodres.2020.109502","volume":"136","author":"PF Cuevas-Gonz\u00e1lez","year":"2020","unstructured":"Cuevas-Gonz\u00e1lez PF, Liceaga AM, Aguilar-Toal\u00e1 JE (2020) Postbiotics and paraprobiotics: from concepts to applications. Food Res Int 136:109502","journal-title":"Food Res Int"},{"key":"10433_CR129","doi-asserted-by":"crossref","unstructured":"Rui W, Zhong S, Li X et al (2024) Evaluating the role of postbiotics in the modulation of human oral microbiota: a randomized controlled clinical trial. Probiotics Antimicrob Proteins 1\u201311","DOI":"10.1007\/s12602-024-10238-y"},{"key":"10433_CR130","doi-asserted-by":"publisher","first-page":"113138","DOI":"10.1016\/j.biopha.2022.113138","volume":"153","author":"Y Bourebaba","year":"2022","unstructured":"Bourebaba Y, Marycz K, Mularczyk M, Bourebaba L (2022) Postbiotics as potential new therapeutic agents for metabolic disorders management. Biomed Pharmacother 153:113138","journal-title":"Biomed Pharmacother"},{"key":"10433_CR131","doi-asserted-by":"publisher","first-page":"108273","DOI":"10.1016\/j.pharmthera.2022.108273","volume":"239","author":"T Ikeda","year":"2022","unstructured":"Ikeda T, Nishida A, Yamano M, Kimura I (2022) Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases. Pharmacol Ther 239:108273","journal-title":"Pharmacol Ther"},{"key":"10433_CR132","doi-asserted-by":"publisher","first-page":"6587","DOI":"10.3390\/jcm11216587","volume":"11","author":"A G\u0105siorowska","year":"2022","unstructured":"G\u0105siorowska A, Romanowski M, Walecka-Kapica E et al (2022) Effects of microencapsulated sodium butyrate, probiotics and short chain fructooligosaccharides in patients with irritable bowel syndrome: a study protocol of a randomized double-blind placebo-controlled trial. J Clin Med 11:6587","journal-title":"J Clin Med"},{"key":"10433_CR133","doi-asserted-by":"publisher","first-page":"113528","DOI":"10.1016\/j.biopha.2022.113528","volume":"153","author":"C Cristiano","year":"2022","unstructured":"Cristiano C, Cuozzo M, Coretti L et al (2022) Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction. Biomed Pharmacother 153:113528","journal-title":"Biomed Pharmacother"},{"key":"10433_CR134","doi-asserted-by":"publisher","first-page":"111772","DOI":"10.1016\/j.yexcr.2019.111772","volume":"387","author":"C-M Qiao","year":"2020","unstructured":"Qiao C-M, Sun M-F, Jia X-B et al (2020) Sodium butyrate causes \u03b1-synuclein degradation by an Atg5-dependent and PI3K\/Akt\/mTOR-related autophagy pathway. Exp Cell Res 387:111772","journal-title":"Exp Cell Res"},{"key":"10433_CR135","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1007\/s11064-020-03074-3","volume":"45","author":"C-M Qiao","year":"2020","unstructured":"Qiao C-M, Sun M-F, Jia X-B et al (2020) Sodium butyrate exacerbates Parkinson\u2019s disease by aggravating neuroinflammation and colonic inflammation in MPTP-induced mice model. Neurochem Res 45:2128\u20132142","journal-title":"Neurochem Res"},{"key":"10433_CR136","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.neuroscience.2013.04.037","volume":"246","author":"RS Laurent","year":"2013","unstructured":"Laurent RS, O\u2019Brien LM, Ahmad S (2013) Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson\u2019s disease. Neuroscience 246:382\u2013390","journal-title":"Neuroscience"},{"key":"10433_CR137","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3390\/ijms24021001","volume":"24","author":"J-AT Matheson","year":"2023","unstructured":"Matheson J-AT, Holsinger RMD (2023) The role of fecal microbiota transplantation in the treatment of neurodegenerative diseases: a review. Int J Mol Sci 24:1001","journal-title":"Int J Mol Sci"},{"key":"10433_CR138","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbi.2018.02.005","volume":"70","author":"M-F Sun","year":"2018","unstructured":"Sun M-F, Zhu Y-L, Zhou Z-L et al (2018) Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson\u2019s disease mice: gut microbiota, glial reaction and TLR4\/TNF-\u03b1 signaling pathway. Brain Behav Immun 70:48\u201360","journal-title":"Brain Behav Immun"},{"key":"10433_CR139","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-021-01107-9","volume":"9","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Ning J, Bao X et al (2021) Fecal microbiota transplantation protects rotenone-induced Parkinson\u2019s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis. Microbiome 9:1\u201327","journal-title":"Microbiome"},{"key":"10433_CR140","first-page":"1","volume":"23","author":"T Zhang","year":"2022","unstructured":"Zhang T, Wang T, Chen X et al (2022) Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson\u2019s disease by protecting the function of dopamine neurons. Exp Ther Med 23:1\u201310","journal-title":"Exp Ther Med"},{"key":"10433_CR141","doi-asserted-by":"publisher","first-page":"993","DOI":"10.3390\/applmicrobiol3030067","volume":"3","author":"T Vongsavath","year":"2023","unstructured":"Vongsavath T, Laeeq T, Tun KM, Hong AS (2023) The potential role of fecal microbiota transplantation in Parkinson\u2019s disease: a systematic literature review. Appl Microbiol 3:993\u20131002","journal-title":"Appl Microbiol"},{"key":"10433_CR142","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1021\/acs.jafc.1c07711","volume":"70","author":"L Wang","year":"2022","unstructured":"Wang L, Zhao Z, Zhao L et al (2022) Lactobacillus plantarum DP189 reduces \u03b1-SYN aggravation in MPTP-induced Parkinson\u2019s disease mice via regulating oxidative damage, inflammation, and gut microbiota disorder. J Agric Food Chem 70:1163\u20131173","journal-title":"J Agric Food Chem"},{"key":"10433_CR143","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","volume":"26","author":"D Heras-Sandoval","year":"2014","unstructured":"Heras-Sandoval D, P\u00e9rez-Rojas JM, Hern\u00e1ndez-Dami\u00e1n J, Pedraza-Chaverri J (2014) The role of PI3K\/AKT\/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal 26:2694\u20132701","journal-title":"Cell Signal"},{"key":"10433_CR144","doi-asserted-by":"publisher","unstructured":"Li T, Chu C, Yu L et al (2022) Neuroprotective effects of Bifidobacterium breve CCFM1067 in MPTP-induced mouse models of Parkinson\u2019s disease. Nutrients 14:. https:\/\/doi.org\/10.3390\/nu14214678","DOI":"10.3390\/nu14214678"},{"key":"10433_CR145","doi-asserted-by":"publisher","first-page":"104635","DOI":"10.1016\/j.jff.2021.104635","volume":"85","author":"L Wang","year":"2021","unstructured":"Wang L, Li S, Jiang YU et al (2021) Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson\u2019s disease model mice. J Funct Foods 85:104635","journal-title":"J Funct Foods"},{"key":"10433_CR146","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.3390\/cells9071687","volume":"9","author":"M Pajares","year":"2020","unstructured":"Pajares M, Rojo AI, Manda G et al (2020) Inflammation in Parkinson\u2019s disease: mechanisms and therapeutic implications. Cells 9:1687","journal-title":"Cells"},{"key":"10433_CR147","doi-asserted-by":"publisher","first-page":"8421","DOI":"10.3390\/ijms21228421","volume":"21","author":"C Marogianni","year":"2020","unstructured":"Marogianni C, Sokratous M, Dardiotis E et al (2020) Neurodegeneration and inflammation\u2014an interesting interplay in Parkinson\u2019s disease. Int J Mol Sci 21:8421","journal-title":"Int J Mol Sci"},{"key":"10433_CR148","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/jnc.14694","volume":"150","author":"X Fang","year":"2019","unstructured":"Fang X, Tian P, Zhao X et al (2019) Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1. J Neurochem 150:441\u2013452","journal-title":"J Neurochem"},{"key":"10433_CR149","doi-asserted-by":"crossref","unstructured":"Wu H, Wei J, Zhao X et al (2023) Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson\u2019s disease in mice by delivering GLP\u20101 and modulating gut microbiota. Bioeng Transl Med 8:e10351","DOI":"10.1002\/btm2.10351"},{"key":"10433_CR150","doi-asserted-by":"crossref","unstructured":"Zhou L, Han D, Wang X, Chen Z (2023) Probiotic formulation VSL# 3 interacts with mesenchymal stromal cells to protect dopaminergic neurons via centrally and peripherally suppressing NOD-like receptor protein 3 inflammasome-mediated inflammation in parkinson\u2019s disease mice. Microbiol Spectr 11:e03208-22","DOI":"10.1128\/spectrum.03208-22"},{"key":"10433_CR151","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.3390\/nu15071737","volume":"15","author":"C Chu","year":"2023","unstructured":"Chu C, Yu L, Li Y et al (2023) Lactobacillus plantarum CCFM405 against rotenone-induced Parkinson\u2019s disease mice via regulating gut microbiota and branched-chain amino acids biosynthesis. Nutrients 15:1737","journal-title":"Nutrients"},{"key":"10433_CR152","doi-asserted-by":"crossref","unstructured":"Parra I, Mart\u00ednez I, V\u00e1squez-Celaya L et al (2023) Neuroprotective and immunomodulatory effects of probiotics in a rat model of Parkinson\u2019s disease. Neurotox Res 41:187\u2013200","DOI":"10.1007\/s12640-022-00627-y"},{"key":"10433_CR153","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.toxrep.2017.03.005","volume":"4","author":"B Fern\u00e1ndez","year":"2017","unstructured":"Fern\u00e1ndez B, Ferrer I, Gil F, Hilfiker S (2017) Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients. Toxicol Rep 4:188\u2013193","journal-title":"Toxicol Rep"},{"key":"10433_CR154","doi-asserted-by":"publisher","first-page":"659584","DOI":"10.3389\/fphar.2021.659584","volume":"12","author":"L Wu","year":"2021","unstructured":"Wu L, Liu M, Liang J et al (2021) Ferroptosis as a new mechanism in Parkinson\u2019s disease therapy using traditional Chinese medicine. Front Pharmacol 12:659584","journal-title":"Front Pharmacol"},{"key":"10433_CR155","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2016.03.016","volume":"280","author":"C Guo","year":"2016","unstructured":"Guo C, Hao L-J, Yang Z-H et al (2016) Deferoxamine-mediated up-regulation of HIF-1\u03b1 prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice. Exp Neurol 280:13\u201323","journal-title":"Exp Neurol"},{"key":"10433_CR156","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1007\/s13311-020-00929-z","volume":"17","author":"Y Tian","year":"2020","unstructured":"Tian Y, Lu J, Hao X et al (2020) FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson\u2019s disease. Neurotherapeutics 17:1796\u20131812","journal-title":"Neurotherapeutics"},{"key":"10433_CR157","first-page":"2092","volume":"7","author":"P Xiong","year":"2012","unstructured":"Xiong P, Chen X, Guo C et al (2012) Baicalin and deferoxamine alleviate iron accumulation in different brain regions of Parkinson\u2019s disease rats. Neural Regen Res 7:2092","journal-title":"Neural Regen Res"},{"key":"10433_CR158","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.brainres.2014.05.048","volume":"1574","author":"JM Fine","year":"2014","unstructured":"Fine JM, Forsberg AC, Renner DB et al (2014) Intranasally-administered deferoxamine mitigates toxicity of 6-OHDA in a rat model of Parkinson\u05f3 s disease. Brain Res 1574:96\u2013104","journal-title":"Brain Res"},{"key":"10433_CR159","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.3390\/biom13101435","volume":"13","author":"L Nechushtai","year":"2023","unstructured":"Nechushtai L, Frenkel D, Pinkas-Kramarski R (2023) Autophagy in Parkinson\u2019s disease. Biomolecules 13:1435","journal-title":"Biomolecules"},{"key":"10433_CR160","doi-asserted-by":"crossref","unstructured":"Kapil L, Kumar V, Kaur S et al (2024) Role of autophagy and mitophagy in neurodegenerative disorders. CNS Neurol Disord Drug Targets 23:367\u2013383","DOI":"10.2174\/1871527322666230327092855"},{"key":"10433_CR161","doi-asserted-by":"publisher","first-page":"774","DOI":"10.33594\/000000172","volume":"53","author":"M Zaylaa","year":"2019","unstructured":"Zaylaa M, Alard J, Kassaa IA et al (2019) Autophagy: a novel mechanism involved in the anti-inflammatory abilities of probiotics. Cell Physiol Biochem 53:774\u2013793","journal-title":"Cell Physiol Biochem"},{"key":"10433_CR162","doi-asserted-by":"publisher","first-page":"e10505","DOI":"10.1002\/btm2.10505","volume":"8","author":"Y Wang","year":"2023","unstructured":"Wang Y, Chen W, Han Y et al (2023) Neuroprotective effect of engineered Clostridium butyricum-pMTL007-GLP-1 on Parkinson\u2019s disease mice models via promoting mitophagy. Bioeng Transl Med 8:e10505","journal-title":"Bioeng Transl Med"},{"key":"10433_CR163","doi-asserted-by":"publisher","unstructured":"Hawrysh PJ, Gao J, Tan S et al (2023) PRKN\/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and Lactococcus lactis. Autophagy 19:2094\u20132110. https:\/\/doi.org\/10.1080\/15548627.2023.2172873","DOI":"10.1080\/15548627.2023.2172873"},{"key":"10433_CR164","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41392-023-01353-3","volume":"8","author":"X Dong-Chen","year":"2023","unstructured":"Dong-Chen X, Yong C, Yang X et al (2023) Signaling pathways in Parkinson\u2019s disease: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 8:73","journal-title":"Signal Transduct Target Ther"},{"key":"10433_CR165","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/med.21714","volume":"41","author":"C Bento-Pereira","year":"2021","unstructured":"Bento-Pereira C, Dinkova-Kostova AT (2021) Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson\u2019s disease. Med Res Rev 41:785\u2013802","journal-title":"Med Res Rev"},{"key":"10433_CR166","doi-asserted-by":"crossref","unstructured":"Bhushan B, Singh NK (2024) Role of astrogliosis in the pathogenesis of Parkinson\u2019s disease: insights into astrocytic Nrf2 pathway as a potential therapeutic target. CNS Neurol Disord Drug Targets 23:1015\u20131029","DOI":"10.2174\/0118715273270473231002104610"},{"key":"10433_CR167","doi-asserted-by":"crossref","unstructured":"Villavicencio Tejo F, Quintanilla RA (2021) Contribution of the Nrf2 pathway on oxidative damage and mitochondrial failure in Parkinson and Alzheimer\u2019s disease. Antioxidants 10:1069","DOI":"10.3390\/antiox10071069"},{"key":"10433_CR168","doi-asserted-by":"publisher","first-page":"630","DOI":"10.3390\/antiox9070630","volume":"9","author":"SA Scuderi","year":"2020","unstructured":"Scuderi SA, Ardizzone A, Paterniti I et al (2020) Antioxidant and anti-inflammatory effect of Nrf2 inducer dimethyl fumarate in neurodegenerative diseases. Antioxidants 9:630","journal-title":"Antioxidants"},{"key":"10433_CR169","doi-asserted-by":"crossref","unstructured":"Khot M, Sood A, Tryphena KP et al (2023) Dimethyl fumarate ameliorates parkinsonian pathology by modulating autophagy and apoptosis via Nrf2-TIGAR-LAMP2\/Cathepsin D axis. Brain Res 1815:148462","DOI":"10.1016\/j.brainres.2023.148462"},{"key":"10433_CR170","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/00207454.2021.1924707","volume":"133","author":"L Zhang","year":"2023","unstructured":"Zhang L, Zhang W, Tian X (2023) The pleiotropic of GLP-1\/GLP-1R axis in central nervous system diseases. Int J Neurosci 133:473\u2013491","journal-title":"Int J Neurosci"},{"key":"10433_CR171","doi-asserted-by":"publisher","first-page":"7565","DOI":"10.1007\/s00253-018-9155-6","volume":"102","author":"T Chen","year":"2018","unstructured":"Chen T, Tian P, Huang Z et al (2018) Engineered commensal bacteria prevent systemic inflammation-induced memory impairment and amyloidogenesis via producing GLP-1. Appl Microbiol Biotechnol 102:7565\u20137575","journal-title":"Appl Microbiol Biotechnol"},{"key":"10433_CR172","doi-asserted-by":"publisher","first-page":"T31","DOI":"10.1530\/JOE-13-0221","volume":"221","author":"C H\u00f6lscher","year":"2014","unstructured":"H\u00f6lscher C (2014) Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. J Endocrinol 221:T31\u2013T41","journal-title":"J Endocrinol"},{"key":"10433_CR173","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3389\/fendo.2018.00672","volume":"9","author":"J Rowlands","year":"2018","unstructured":"Rowlands J, Heng J, Newsholme P, Carlessi R (2018) Pleiotropic effects of GLP-1 and analogs on cell signaling, metabolism, and function. Front Endocrinol (Lausanne) 9:672","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10433_CR174","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s11910-022-01196-5","volume":"22","author":"RA Manfready","year":"2022","unstructured":"Manfready RA, Forsyth CB, Voigt RM et al (2022) Gut-brain communication in Parkinson\u2019s disease: enteroendocrine regulation by GLP-1. Curr Neurol Neurosci Rep 22:335\u2013342","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10433_CR175","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.yfrne.2017.09.002","volume":"50","author":"JC Jurado-Coronel","year":"2018","unstructured":"Jurado-Coronel JC, Cabezas R, Rodr\u00edguez MF\u00c1 et al (2018) Sex differences in Parkinson\u2019s disease: features on clinical symptoms, treatment outcome, sexual hormones and genetics. Front Neuroendocrinol 50:18\u201330","journal-title":"Front Neuroendocrinol"},{"key":"10433_CR176","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.biopsych.2021.01.002","volume":"91","author":"C Lopez-Lee","year":"2022","unstructured":"Lopez-Lee C, Kodama L, Gan L (2022) Sex differences in neurodegeneration: the role of the immune system in humans. Biol Psychiatry 91:72\u201380","journal-title":"Biol Psychiatry"},{"key":"10433_CR177","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3233\/JPD-212892","volume":"12","author":"M Picillo","year":"2022","unstructured":"Picillo M, LaFontant D-E, Bressman S et al (2022) Sex-related longitudinal change of motor, non-motor, and biological features in early Parkinson\u2019s disease. J Parkinsons Dis 12:421\u2013436","journal-title":"J Parkinsons Dis"},{"key":"10433_CR178","doi-asserted-by":"crossref","unstructured":"Lee J-Y (2024) Sex\/gender differences in Parkinson\u2019s disease. In: Sex\/gender-specific medicine in clinical areas. Springer, pp 435\u2013442","DOI":"10.1007\/978-981-97-0130-8_26"},{"key":"10433_CR179","doi-asserted-by":"publisher","unstructured":"Vaidya B, Dhamija K, Guru P, Sharma SS (2021) Parkinson\u2019s disease in women: mechanisms underlying sex differences. Eur J Pharmacol 895:. https:\/\/doi.org\/10.1016\/j.ejphar.2021.173862","DOI":"10.1016\/j.ejphar.2021.173862"},{"key":"10433_CR180","doi-asserted-by":"crossref","unstructured":"Bianco A, Antonacci Y, Liguori M (2023) Sex and gender differences in neurodegenerative diseases: challenges for therapeutic opportunities. Int J Mol Sci 24:6354","DOI":"10.3390\/ijms24076354"},{"key":"10433_CR181","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3233\/JPD-191683","volume":"9","author":"S Cerri","year":"2019","unstructured":"Cerri S, Mus L, Blandini F (2019) Parkinson\u2019s disease in women and men: what\u2019s the difference? J Parkinsons Dis 9:501\u2013515","journal-title":"J Parkinsons Dis"},{"key":"10433_CR182","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1002\/mds.23388","volume":"25","author":"IN Miller","year":"2010","unstructured":"Miller IN, Cronin-Golomb A (2010) Gender differences in Parkinson\u2019s disease: clinical characteristics and cognition. Mov Disord 25:2695\u20132703","journal-title":"Mov Disord"},{"key":"10433_CR183","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1007\/s00415-016-8384-9","volume":"264","author":"M Picillo","year":"2017","unstructured":"Picillo M, Nicoletti A, Fetoni V et al (2017) The relevance of gender in Parkinson\u2019s disease: a review. J Neurol 264:1583\u20131607","journal-title":"J Neurol"},{"key":"10433_CR184","doi-asserted-by":"crossref","unstructured":"Khanouchi M, Laadraoui J, El Amine S et al (2023) Sex dimorphism and Parkinson\u2019s disease: what we learned. In: Experimental and clinical evidence of the neuropathology of Parkinson\u2019s disease. IGI Global, pp 144\u2013163","DOI":"10.4018\/978-1-6684-5156-4.ch009"},{"key":"10433_CR185","doi-asserted-by":"publisher","first-page":"105661","DOI":"10.1016\/j.neuint.2023.105661","volume":"173","author":"X Zhou","year":"2024","unstructured":"Zhou X, Gao Y, Wei J et al (2024) The intestinal microbiota exerts a sex-specific influence on neuroinflammation in a Parkinson\u2019s disease mouse model. Neurochem Int 173:105661","journal-title":"Neurochem Int"},{"key":"10433_CR186","doi-asserted-by":"publisher","unstructured":"Sbrini G, Mutti V, Bono F et al (2024) 17-\u03b2-estradiol potentiates the neurotrophic and neuroprotective effects mediated by the dopamine D3\/acetylcholine nicotinic receptor heteromer in dopaminergic neurons. Eur J Pharmacol 976:. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176678","DOI":"10.1016\/j.ejphar.2024.176678"},{"key":"10433_CR187","doi-asserted-by":"publisher","unstructured":"Korf JM, Ganesh BP, McCullough LD (2022) Gut dysbiosis and age-related neurological diseases in females. Neurobiol Dis 168:. https:\/\/doi.org\/10.1016\/j.nbd.2022.105695","DOI":"10.1016\/j.nbd.2022.105695"},{"key":"10433_CR188","doi-asserted-by":"publisher","unstructured":"Hall DA, Voigt RM, Cantu-Jungles TM et al (2023) An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson\u2019s disease participants. Nat Commun 14:. https:\/\/doi.org\/10.1038\/s41467-023-36497-x","DOI":"10.1038\/s41467-023-36497-x"},{"key":"10433_CR189","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.gpb.2021.08.009","volume":"20","author":"A Becker","year":"2022","unstructured":"Becker A, Schmartz GP, Gr\u00f6ger L et al (2022) Effects of resistant starch on symptoms, fecal markers, and gut microbiota in Parkinson\u2019s disease \u2014 the RESISTA-PD trial. Genomics Proteomics Bioinformatics 20:274\u2013287. https:\/\/doi.org\/10.1016\/j.gpb.2021.08.009","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10433_CR190","doi-asserted-by":"publisher","first-page":"6828","DOI":"10.1039\/d3fo00728f","volume":"14","author":"X Yang","year":"2023","unstructured":"Yang X, He X, Xu S et al (2023) Effect of Lacticaseibacillus paracasei strain Shirota supplementation on clinical responses and gut microbiome in Parkinson\u2019s disease. Food Funct 14:6828\u20136839. https:\/\/doi.org\/10.1039\/d3fo00728f","journal-title":"Food Funct"},{"key":"10433_CR191","unstructured":"Borzabadi S, Oryan S, Eidi A, Asemi Z (2018) The effects of probiotic supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson\u2019s disease: a randomized, double-blind, placebo-controlled trial. Arch Iran Med 21:289\u2013295"},{"key":"10433_CR192","doi-asserted-by":"publisher","unstructured":"Mehrabani S, Khorvash F, Heidari Z, et al (2023) The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson\u2019s disease: a double-blind, placebo-controlled, randomized controlled trial. J Funct Foods 100:. https:\/\/doi.org\/10.1016\/j.jff.2022.105397","DOI":"10.1016\/j.jff.2022.105397"},{"key":"10433_CR193","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1212\/WNL.0000000000003127","volume":"87","author":"M Barichella","year":"2016","unstructured":"Barichella M, Pacchetti C, Bolliri C et al (2016) Probiotics and prebiotic fiber for constipation associated with Parkinson disease. Neurology 87:1274\u20131280. https:\/\/doi.org\/10.1212\/WNL.0000000000003127","journal-title":"Neurology"},{"key":"10433_CR194","doi-asserted-by":"publisher","unstructured":"Ibrahim A, Raja Ali RA, Abdul Manaf MR et al (2020) Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson\u2019s disease: a randomised controlled trial. PLoS One 15:. https:\/\/doi.org\/10.1371\/journal.pone.0244680","DOI":"10.1371\/journal.pone.0244680"},{"key":"10433_CR195","doi-asserted-by":"publisher","unstructured":"Chui ZSW, Chan LML, Zhang EWH et al (2024) Effects of microbiome-based interventions on neurodegenerative diseases: a systematic review and meta-analysis. Sci Rep 14:. https:\/\/doi.org\/10.1038\/s41598-024-59250-w","DOI":"10.1038\/s41598-024-59250-w"},{"key":"10433_CR196","doi-asserted-by":"crossref","unstructured":"Zhang X, Tang B, Guo J (2023) Parkinson\u2019s disease and gut microbiota: from clinical to mechanistic and therapeutic studies. Transl Neurodegener 12:59","DOI":"10.1186\/s40035-023-00392-8"},{"key":"10433_CR197","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3748\/wjg.v30.i3.225","volume":"30","author":"XY Yuan","year":"2024","unstructured":"Yuan XY, Sen CY, Liu Z (2024) Relationship among Parkinson\u2019s disease, constipation, microbes, and microbiological therapy. World J Gastroenterol 30:225\u2013237","journal-title":"World J Gastroenterol"},{"key":"10433_CR198","doi-asserted-by":"publisher","first-page":"e00060","DOI":"10.1128\/cmr.00060-22","volume":"37","author":"Y Abbas","year":"2024","unstructured":"Abbas Y, Haggai B-Y, Marie MT et al (2024) Fecal microbiota transplantation: current challenges and future landscapes. Clin Microbiol Rev 37:e00060-e122. https:\/\/doi.org\/10.1128\/cmr.00060-22","journal-title":"Clin Microbiol Rev"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10433-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-024-10433-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-024-10433-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:05:37Z","timestamp":1756901137000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-024-10433-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":198,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10433"],"URL":"https:\/\/doi.org\/10.1007\/s12602-024-10433-x","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"assertion":[{"value":"9 December 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}