{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:24:14Z","timestamp":1787167454638,"version":"build-2736575974"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12602-025-10472-y","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:12:01Z","timestamp":1738581121000},"page":"5122-5147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Protective Role of Nano-encapsulated Bifidobacterium breve, Bacilllus coagulans, and Lactobacillus plantarum in Colitis Model: Insights Toward Propagation of Short-Chain Fatty Acids and Reduction of Exaggerated Inflammatory and Oxidative Response"],"prefix":"10.1007","volume":"17","author":[{"given":"Doaa","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa I.","family":"Khater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda S.","family":"Sherkawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Elgamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A.","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A.","family":"Muhammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed F. M.","family":"Farag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar A.","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer Ahmed","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemmat M.","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej A.","family":"Eskandrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa S.","family":"Alansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahran Mohamed Abd","family":"El-Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"issue":"7","key":"10472_CR1","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/s41591-021-01390-x","volume":"27","author":"BM Scott","year":"2021","unstructured":"Scott BM, Gutierrez-Vazquez C, Sanmarco LM, da Silva Pereira JA, Li Z, Plasencia A et al (2021) Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nat Med 27(7):1212\u20131222","journal-title":"Nat Med"},{"issue":"1","key":"10472_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","volume":"18","author":"GG Kaplan","year":"2021","unstructured":"Kaplan GG, Windsor JW (2021) The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 18(1):56\u201366","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10472_CR3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3389\/fimmu.2015.00551","volume":"6","author":"I Loddo","year":"2015","unstructured":"Loddo I, Romano C (2015) Inflammatory bowel disease: genetics, epigenetics, and pathogenesis. Front Immunol 6:551","journal-title":"Front Immunol"},{"key":"10472_CR4","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.jconrel.2022.05.025","volume":"347","author":"S Liu","year":"2022","unstructured":"Liu S, Cao Y, Ma L, Sun J, Ramos-Mucci L, Ma Y et al (2022) Oral antimicrobial peptide-EGCG nanomedicines for synergistic treatment of ulcerative colitis. J Control Release 347:544\u2013560","journal-title":"J Control Release"},{"issue":"4","key":"10472_CR5","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1053\/j.gastro.2017.11.003","volume":"154","author":"M Darnaud","year":"2018","unstructured":"Darnaud M, Dos Santos A, Gonzalez P, Augui S, Lacoste C, Desterke C et al (2018) Enteric delivery of regenerating family member 3 alpha alters the intestinal microbiota and controls inflammation in mice with colitis. Gastroenterology. 154(4):1009\u201323.e14","journal-title":"Gastroenterology."},{"issue":"4","key":"10472_CR6","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1152\/ajpgi.00103.2019","volume":"317","author":"X Li","year":"2019","unstructured":"Li X, Wei X, Sun Y, Du J, Li X, Xun Z et al (2019) High-fat diet promotes experimental colitis by inducing oxidative stress in the colon. Am J Physiol-Gastrointesti Liver Physiol 317(4):453\u201362","journal-title":"Am J Physiol-Gastrointesti Liver Physiol"},{"issue":"2","key":"10472_CR7","doi-asserted-by":"publisher","first-page":"2265028","DOI":"10.1080\/19490976.2023.2265028","volume":"15","author":"Y Tie","year":"2023","unstructured":"Tie Y, Huang Y, Chen R, Li L, Chen M, Zhang S (2023) Current insights on the roles of gut microbiota in inflammatory bowel disease-associated extra-intestinal manifestations: pathophysiology and therapeutic targets. Gut Microbes 15(2):2265028","journal-title":"Gut Microbes"},{"key":"10472_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-021-01028-7","volume":"9","author":"D Li","year":"2021","unstructured":"Li D, Feng Y, Tian M, Ji J, Hu X, Chen F (2021) Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPAR\u03b3 signaling activation. Microbiome 9:1\u201322","journal-title":"Microbiome"},{"issue":"6","key":"10472_CR9","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.1039\/D0FO00439A","volume":"11","author":"Y Liu","year":"2020","unstructured":"Liu Y, Gao Y, Ma F, Sun M, Mu G, Tuo Y (2020) The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet. Food Funct 11(6):5024\u20135039","journal-title":"Food Funct"},{"key":"10472_CR10","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.carbpol.2018.05.003","volume":"195","author":"X Wang","year":"2018","unstructured":"Wang X, Wang X, Jiang H, Cai C, Li G, Hao J et al (2018) Marine polysaccharides attenuate metabolic syndrome by fermentation products and altering gut microbiota: an overview. Carbohyd Polym 195:601\u2013612","journal-title":"Carbohyd Polym"},{"issue":"13","key":"10472_CR11","doi-asserted-by":"publisher","first-page":"11312","DOI":"10.1074\/jbc.M211609200","volume":"278","author":"AJ Brown","year":"2003","unstructured":"Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D et al (2003) The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278(13):11312\u201311319","journal-title":"J Biol Chem"},{"issue":"2","key":"10472_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1574-6968.2002.tb11467.x","volume":"217","author":"SE Pryde","year":"2002","unstructured":"Pryde SE, Duncan SH, Hold GL, Stewart CS, Flint HJ (2002) The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett 217(2):133\u2013139","journal-title":"FEMS Microbiol Lett"},{"key":"10472_CR13","doi-asserted-by":"publisher","first-page":"135592","DOI":"10.1016\/j.foodchem.2023.135592","volume":"412","author":"X Li","year":"2023","unstructured":"Li X, An S, Luo Z, Zhou P, Wang L, Feng R (2023) Polysaccharides from the hard shells of Juglans regia L. modulate intestinal function and gut microbiota in vivo. Food Chem. 412:135592","journal-title":"Food Chem."},{"issue":"1","key":"10472_CR14","doi-asserted-by":"publisher","first-page":"12649","DOI":"10.1038\/s41598-018-30114-4","volume":"8","author":"R Nagpal","year":"2018","unstructured":"Nagpal R, Wang S, Ahmadi S, Hayes J, Gagliano J, Subashchandrabose S et al (2018) Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome. Sci Rep 8(1):12649","journal-title":"Sci Rep"},{"issue":"1 Suppl","key":"10472_CR15","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1136\/gut.35.1_Suppl.S35","volume":"35","author":"W Scheppach","year":"1994","unstructured":"Scheppach W (1994) Effects of short chain fatty acids on gut morphology and function. Gut 35(1 Suppl):S35\u2013S38","journal-title":"Gut"},{"issue":"9","key":"10472_CR16","doi-asserted-by":"publisher","first-page":"5850","DOI":"10.3168\/jds.2014-9153","volume":"98","author":"R Huang","year":"2015","unstructured":"Huang R, Tao X, Wan C, Li S, Xu H, Xu F et al (2015) In vitro probiotic characteristics of Lactobacillus plantarum ZDY 2013 and its modulatory effect on gut microbiota of mice. J Dairy Sci 98(9):5850\u20135861","journal-title":"J Dairy Sci"},{"key":"10472_CR17","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s00535-021-01774-3","volume":"56","author":"AM Dias","year":"2021","unstructured":"Dias AM, Douhard R, Hermetet F, Regimbeau M, Lopez TE, Gonzalez D et al (2021) Lactobacillus stress protein GroEL prevents colonic inflammation. J Gastroenterol 56:442\u2013455","journal-title":"J Gastroenterol"},{"issue":"11","key":"10472_CR18","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3390\/microorganisms8111715","volume":"8","author":"S Stojanov","year":"2020","unstructured":"Stojanov S, Berlec A, \u0160trukelj B (2020) The influence of probiotics on the Firmicutes\/Bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease. Microorganisms 8(11):1715","journal-title":"Microorganisms"},{"issue":"1","key":"10472_CR19","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1016\/j.sjbs.2015.09.022","volume":"23","author":"MV Arasu","year":"2016","unstructured":"Arasu MV, Al-Dhabi NA, Ilavenil S, Choi KC, Srigopalram S (2016) In vitro importance of probiotic Lactobacillus plantarum related to medical field. Saudi J Biol Sci 23(1):S6\u2013S10","journal-title":"Saudi J Biol Sci"},{"key":"10472_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.anaerobe.2014.03.003","volume":"27","author":"J-Y Woo","year":"2014","unstructured":"Woo J-Y, Gu W, Kim K-A, Jang S-E, Han MJ, Kim D-H (2014) Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model. Anaerobe 27:22\u20136","journal-title":"Anaerobe"},{"key":"10472_CR21","doi-asserted-by":"publisher","first-page":"6337","DOI":"10.1007\/s00253-020-10693-x","volume":"104","author":"A Hassan","year":"2020","unstructured":"Hassan A, Din AU, Zhu Y, Zhang K, Li T, Wang Y et al (2020) Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE\u2212\/\u2212 mice through modulation of proinflammatory cytokines and oxidative stress. Appl Microbiol Biotechnol 104:6337\u20136350","journal-title":"Appl Microbiol Biotechnol"},{"key":"10472_CR22","doi-asserted-by":"publisher","first-page":"9416391","DOI":"10.1155\/2018\/9416391","volume":"2018","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Zhao X, Zhu Y, Ma J, Ma H, Zhang H (2018) Probiotic mixture protects dextran sulfate sodium-induced colitis by altering tight junction protein expressions and increasing Tregs. Mediators of Inflammation 2018:9416391","journal-title":"Mediators of Inflammation"},{"issue":"6","key":"10472_CR23","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3920\/BM2019.0016","volume":"10","author":"Y Mu","year":"2019","unstructured":"Mu Y, Cong Y (2019) Bacillus coagulans and its applications in medicine. Beneficial microbes 10(6):679\u2013688","journal-title":"Beneficial microbes"},{"issue":"4","key":"10472_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25(4):402\u20138","journal-title":"Methods"},{"key":"10472_CR25","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.ijbiomac.2022.01.143","volume":"203","author":"X Li","year":"2022","unstructured":"Li X, Zhou P, Luo Z, Feng R, Wang L (2022) Hohenbuehelia serotina polysaccharides self-assembled nanoparticles for delivery of quercetin and their anti-proliferative activities during gastrointestinal digestion in vitro. Int J Biol Macromol 203:244\u2013255","journal-title":"Int J Biol Macromol"},{"key":"10472_CR26","doi-asserted-by":"publisher","first-page":"102993","DOI":"10.1016\/j.ifset.2022.102993","volume":"78","author":"P Zhou","year":"2022","unstructured":"Zhou P, Wang L, An S, Wang C, Jiang Q, Li X (2022) Fabrication of quercetin-loaded nanoparticles based on Hohenbuehelia serotina polysaccharides and their modulatory effects on intestinal function and gut microbiota in vivo. Innov Food Sci Emerg Technol 78:102993","journal-title":"Innov Food Sci Emerg Technol"},{"issue":"2","key":"10472_CR27","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3390\/nano9020296","volume":"9","author":"J Jampilek","year":"2019","unstructured":"Jampilek J, Kos J, Kralova K (2019) Potential of nanomaterial applications in dietary supplements and foods for special medical purposes. Nanomaterials 9(2):296","journal-title":"Nanomaterials"},{"key":"10472_CR28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cis.2017.05.010","volume":"246","author":"DJ McClements","year":"2017","unstructured":"McClements DJ, Xiao H, Demokritou P (2017) Physicochemical and colloidal aspects of food matrix effects on gastrointestinal fate of ingested inorganic nanoparticles. Adv Colloid Interface Sci 246:165\u2013180","journal-title":"Adv Colloid Interface Sci"},{"issue":"8","key":"10472_CR29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.idairyj.2004.01.004","volume":"14","author":"W Krasaekoopt","year":"2004","unstructured":"Krasaekoopt W, Bhandari B, Deeth H (2004) The influence of coating materials on some properties of alginate beads and survivability of microencapsulated probiotic bacteria. Int Dairy J 14(8):737\u2013743","journal-title":"Int Dairy J"},{"issue":"1","key":"10472_CR30","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.1038\/s41598-022-08915-5","volume":"12","author":"AG Alkushi","year":"2022","unstructured":"Alkushi AG, Abdelfattah-Hassan A, Eldoumani H, Elazab ST, Mohamed SA, Metwally AS et al (2022) Probiotics-loaded nanoparticles attenuated colon inflammation, oxidative stress, and apoptosis in colitis. Sci Rep 12(1):5116","journal-title":"Sci Rep"},{"issue":"2","key":"10472_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3390\/biology11020303","volume":"11","author":"IA Alsharif","year":"2022","unstructured":"Alsharif IA, Fayed HM, Abdel-Rahman RF, Abd-Elsalam RM, Ogaly HA (2022) Miconazole mitigates acetic acid-induced experimental colitis in rats: insight into inflammation, oxidative stress and Keap1\/Nrf-2 signaling crosstalk. Biology 11(2):303","journal-title":"Biology"},{"issue":"8","key":"10472_CR32","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3390\/nu9080875","volume":"9","author":"K Wang","year":"2017","unstructured":"Wang K, Jin X, You M, Tian W, Le Leu RK, Topping DL et al (2017) Dietary propolis ameliorates dextran sulfate sodium-induced colitis and modulates the gut microbiota in rats fed a western diet. Nutrients 9(8):875","journal-title":"Nutrients"},{"issue":"3","key":"10472_CR33","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/ar.22641","volume":"296","author":"EC Jensen","year":"2013","unstructured":"Jensen EC (2013) Quantitative analysis of histological staining and fluorescence using ImageJ. Anat Rec 296(3):378\u2013381","journal-title":"Anat Rec"},{"key":"10472_CR34","volume-title":"Clinical hematology: theory and procedures","author":"ML Turgeon","year":"2005","unstructured":"Turgeon ML (2005) Clinical hematology: theory and procedures. Lippincott Williams & Wilkins"},{"key":"10472_CR35","doi-asserted-by":"publisher","first-page":"123511","DOI":"10.1016\/j.ijpharm.2023.123511","volume":"647","author":"D Ibrahim","year":"2023","unstructured":"Ibrahim D, Khater SI, Abdelfattah-Hassan A, Alqahtani LS, Metwally AS, Bazeed SM et al (2023) Prospects of new targeted nanotherapy combining liponiosomes with berberine to combat colorectal cancer development: an in vivo experimental model. Int J Pharm 647:123511","journal-title":"Int J Pharm"},{"issue":"6","key":"10472_CR36","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","volume":"87","author":"J Krawisz","year":"1984","unstructured":"Krawisz J, Sharon P, Stenson W (1984) Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: assessment of inflammation in rat and hamster models. Gastroenterology 87(6):1344\u20131350","journal-title":"Gastroenterology"},{"issue":"1","key":"10472_CR37","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1006\/niox.2000.0319","volume":"5","author":"KM Miranda","year":"2001","unstructured":"Miranda KM, Espey MG, Wink DA (2001) A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5(1):62\u201371","journal-title":"Nitric Oxide"},{"key":"10472_CR38","doi-asserted-by":"publisher","first-page":"106062","DOI":"10.1016\/j.intimp.2019.106062","volume":"78","author":"Z Wang","year":"2020","unstructured":"Wang Z, Zhang X, Zhu L, Yang X, He F, Wang T et al (2020) Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice. Int Immunopharmacol 78:106062","journal-title":"Int Immunopharmacol"},{"key":"10472_CR39","doi-asserted-by":"publisher","first-page":"116215","DOI":"10.1016\/j.jep.2023.116215","volume":"308","author":"Z Li","year":"2023","unstructured":"Li Z, Song Y, Xu W, Chen J, Zhou R, Yang M et al (2023) Pulsatilla chinensis saponins improve SCFAs regulating GPR43-NLRP3 signaling pathway in the treatment of ulcerative colitis. J Ethnopharmacol 308:116215","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10472_CR40","doi-asserted-by":"publisher","first-page":"7742","DOI":"10.1038\/s41598-021-86990-w","volume":"11","author":"D Ibrahim","year":"2021","unstructured":"Ibrahim D, Abdelfattah-Hassan A, Badawi M, Ismail TA, Bendary MM, Abdelaziz AM et al (2021) Thymol nanoemulsion promoted broiler chicken\u2019s growth, gastrointestinal barrier and bacterial community and conferred protection against Salmonella Typhimurium. Sci Rep 11(1):7742","journal-title":"Sci Rep"},{"issue":"3","key":"10472_CR41","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nprot.2007.41","volume":"2","author":"S Wirtz","year":"2007","unstructured":"Wirtz S, Neufert C, Weigmann B, Neurath MF (2007) Chemically induced mouse models of intestinal inflammation. Nat Protoc 2(3):541\u2013546","journal-title":"Nat Protoc"},{"issue":"9","key":"10472_CR42","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.3390\/cells10092475","volume":"10","author":"EM El Nashar","year":"2021","unstructured":"El Nashar EM, Alghamdi MA, Alasmari WA, Hussein MM, Hamza E, Taha RI et al (2021) Autophagy promotes the survival of adipose mesenchymal stem\/stromal cells and enhances their therapeutic effects in cisplatin-induced liver injury via modulating TGF-\u03b21\/Smad and PI3K\/AKT signaling pathways. Cells 10(9):2475","journal-title":"Cells"},{"issue":"4","key":"10472_CR43","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.3390\/nu12041107","volume":"12","author":"P Markowiak-Kope\u0107","year":"2020","unstructured":"Markowiak-Kope\u0107 P, \u015ali\u017cewska K (2020) The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome. Nutrients 12(4):1107","journal-title":"Nutrients"},{"issue":"11","key":"10472_CR44","first-page":"1487","volume":"51","author":"G Reid","year":"2005","unstructured":"Reid G, Hammond J-A (2005) Probiotics. Some evidence of their effectiveness. Can Fam Phys 51(11):1487\u201393","journal-title":"Can Fam Phys"},{"issue":"7","key":"10472_CR45","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.3748\/wjg.v22.i7.2219","volume":"22","author":"E Distrutti","year":"2016","unstructured":"Distrutti E, Monaldi L, Ricci P, Fiorucci S (2016) Gut microbiota role in irritable bowel syndrome: new therapeutic strategies. World J Gastroenterol 22(7):2219","journal-title":"World J Gastroenterol"},{"issue":"11","key":"10472_CR46","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1111\/bph.13632","volume":"174","author":"D Curr\u00f2","year":"2017","unstructured":"Curr\u00f2 D, Ianiro G, Pecere S, Bibb\u00f2 S, Cammarota G (2017) Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. Br J Pharmacol 174(11):1426\u20131449","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10472_CR47","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1159\/000479000","volume":"96","author":"T Ohtsu","year":"2017","unstructured":"Ohtsu T, Takagi A, Uemura N, Inoue K, Sekino H, Kawashima A et al (2017) The ameliorating effect of Lactobacillus gasseri OLL2716 on functional dyspepsia in Helicobacter pylori-uninfected individuals: a randomized controlled study. Digestion 96(2):92\u2013102","journal-title":"Digestion"},{"key":"10472_CR48","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3389\/fphar.2020.00339","volume":"11","author":"Z Tang","year":"2020","unstructured":"Tang Z, Xiong D, Song J, Ye M, Liu J, Wang Z et al (2020) Antitumor drug combretastatin-A4 phosphate aggravates the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice. Front Pharmacol 11:339","journal-title":"Front Pharmacol"},{"issue":"1","key":"10472_CR49","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1128\/CMR.15.1.79-94.2002","volume":"15","author":"BA Hendrickson","year":"2002","unstructured":"Hendrickson BA, Gokhale R, Cho JH (2002) Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev 15(1):79\u201394","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10472_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41522-021-00228-1","volume":"7","author":"M Yao","year":"2021","unstructured":"Yao M, Lu Y, Zhang T, Xie J, Han S, Zhang S et al (2021) Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation. Npj Biofilms Microbiomes 7(1):1\u201310","journal-title":"Npj Biofilms Microbiomes"},{"issue":"10","key":"10472_CR51","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-018-0034-5","volume":"15","author":"M Simr\u00e9n","year":"2018","unstructured":"Simr\u00e9n M, Tack J (2018) New treatments and therapeutic targets for IBS and other functional bowel disorders. Nat Rev Gastroenterol Hepatol 15(10):589\u2013605","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"10472_CR52","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.3390\/cells9081824","volume":"9","author":"G Leccese","year":"2020","unstructured":"Leccese G, Bibi A, Mazza S, Facciotti F, Caprioli F, Landini P et al (2020) Probiotic Lactobacillus and Bifidobacterium strains counteract adherent-invasive Escherichia coli (AIEC) virulence and hamper IL-23\/Th17 axis in ulcerative colitis, but not in Crohn\u2019s disease. Cells 9(8):1824","journal-title":"Cells"},{"issue":"1","key":"10472_CR53","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3748\/wjg.v24.i1.5","volume":"24","author":"Z-H Shen","year":"2018","unstructured":"Shen Z-H, Zhu C-X, Quan Y-S, Yang Z-Y, Wu S, Luo W-W et al (2018) Relationship between intestinal microbiota and ulcerative colitis: mechanisms and clinical application of probiotics and fecal microbiota transplantation. World J Gastroenterol 24(1):5","journal-title":"World J Gastroenterol"},{"issue":"7","key":"10472_CR54","first-page":"1329","volume":"19","author":"T Magrone","year":"2013","unstructured":"Magrone T, Jirillo E (2013) The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis. Curr Pharm Des 19(7):1329\u20131342","journal-title":"Curr Pharm Des"},{"issue":"10","key":"10472_CR55","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1139\/cjm-2015-0201","volume":"61","author":"Y Zhu","year":"2015","unstructured":"Zhu Y, Wang C, Li F (2015) Impact of dietary fiber\/starch ratio in shaping caecal microbiota in rabbits. Can J Microbiol 61(10):771\u2013784","journal-title":"Can J Microbiol"},{"issue":"3","key":"10472_CR56","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tmrv.2020.04.002","volume":"34","author":"S Dzik","year":"2020","unstructured":"Dzik S (2020) COVID-19 convalescent plasma: now is the time for better science. Transfus Med Rev 34(3):141","journal-title":"Transfus Med Rev"},{"issue":"4","key":"10472_CR57","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrg3182","volume":"13","author":"I Cho","year":"2012","unstructured":"Cho I, Blaser MJ (2012) The human microbiome: at the interface of health and disease. Nat Rev Genet 13(4):260\u2013270","journal-title":"Nat Rev Genet"},{"key":"10472_CR58","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.3389\/fmicb.2018.03260","volume":"9","author":"G Cao","year":"2019","unstructured":"Cao G, Wang K, Li Z, Tao F, Xu Y, Lan J et al (2019) Bacillus amyloliquefaciens ameliorates dextran sulfate sodium-induced colitis by improving gut microbial dysbiosis in mice model. Front Microbiol 9:3260","journal-title":"Front Microbiol"},{"key":"10472_CR59","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ijbiomac.2021.03.065","volume":"180","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Liu L, Sun Z, Ji Y, Wang D, Mei L et al (2021) Fucoidan as a marine-origin prebiotic modulates the growth and antibacterial ability of Lactobacillus rhamnosus. Int J Biol Macromol 180:599\u2013607","journal-title":"Int J Biol Macromol"},{"key":"10472_CR60","doi-asserted-by":"crossref","unstructured":"Hansberry DR, Shah K, Agarwal P, Agarwal N (2017) Fecal myeloperoxidase as a biomarker for inflammatory bowel disease. Cureus 9(1).","DOI":"10.7759\/cureus.1004"},{"issue":"11","key":"10472_CR61","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1002\/prca.201600028","volume":"10","author":"W Schr\u00f6dl","year":"2016","unstructured":"Schr\u00f6dl W, B\u00fcchler R, Wendler S, Reinhold P, Muckova P, Reindl J et al (2016) Acute phase proteins as promising biomarkers: perspectives and limitations for human and veterinary medicine. PROTEOMICS\u2013Clin Appl 10(11):1077\u201392","journal-title":"PROTEOMICS\u2013Clin Appl"},{"issue":"9","key":"10472_CR62","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.3390\/ijms22094485","volume":"22","author":"E \u017by\u0142a","year":"2021","unstructured":"\u017by\u0142a E, Dziendzikowska K, Kamola D, Wilczak J, Sapierzy\u0144ski R, Harasym J et al (2021) Anti-inflammatory activity of oat beta-glucans in a Crohn\u2019s disease model: time-and molar mass-dependent effects. Int J Mol Sci 22(9):4485","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10472_CR63","first-page":"528","volume":"33","author":"T Kirdak","year":"2020","unstructured":"Kirdak T, Uysal E, Sezgin E, Cecen GS, Cavun S (2020) Inflammatory response markers in rats undergoing abdominal surgical procedures. Ann Gastroenterol 33(5):528","journal-title":"Ann Gastroenterol"},{"issue":"2","key":"10472_CR64","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.pharep.2016.11.002","volume":"69","author":"AA Ali","year":"2017","unstructured":"Ali AA, Abd Al Haleem EN, Khaleel SA-H, Sallam AS (2017) Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats. Pharmacol Rep 69(2):268\u201375","journal-title":"Pharmacol Rep"},{"issue":"33","key":"10472_CR65","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.3748\/wjg.v16.i33.4145","volume":"16","author":"SK Hegazy","year":"2010","unstructured":"Hegazy SK, El-Bedewy MM (2010) Effect of probiotics on pro-inflammatory cytokines and NF-\u03baB activation in ulcerative colitis. World J Gastroenterol: WJG 16(33):4145","journal-title":"World J Gastroenterol: WJG"},{"issue":"1\u20132","key":"10472_CR66","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ijfoodmicro.2010.06.022","volume":"142","author":"M Ch\u00e1varri","year":"2010","unstructured":"Ch\u00e1varri M, Mara\u00f1\u00f3n I, Ares R, Ib\u00e1\u00f1ez FC, Marzo F, del Carmen VM (2010) Microencapsulation of a probiotic and prebiotic in alginate-chitosan capsules improves survival in simulated gastro-intestinal conditions. Int J Food Microbiol 142(1\u20132):185\u2013189","journal-title":"Int J Food Microbiol"},{"issue":"3","key":"10472_CR67","first-page":"2341","volume":"17","author":"Y Gong","year":"2019","unstructured":"Gong Y, Niu W, Tang Y, Zhang Q, Liu S, Liu X et al (2019) Aggravated mucosal and immune damage in a mouse model of ulcerative colitis with stress. Exp Ther Med 17(3):2341\u20132348","journal-title":"Exp Ther Med"},{"issue":"27","key":"10472_CR68","first-page":"1720","volume":"46","author":"I Gouni-Berthold","year":"1999","unstructured":"Gouni-Berthold I, Baumeister B, Berthold H, Schmidt C (1999) Immunoglobulins and IgG subclasses in patients with inflammatory bowel disease. Hepatogastroenterology 46(27):1720\u20131723","journal-title":"Hepatogastroenterology"},{"issue":"1","key":"10472_CR69","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3109\/00365529509093235","volume":"30","author":"E Philipsen","year":"1995","unstructured":"Philipsen E, Bondesen S, Andersen J, Larsen S (1995) Serum immunoglobulin G subclasses in patients with ulcerative colitis and Crohn\u2019s disease of different disease activities. Scand J Gastroenterol 30(1):50\u201353","journal-title":"Scand J Gastroenterol"},{"key":"10472_CR70","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3389\/fimmu.2019.00945","volume":"10","author":"H Kubagawa","year":"2019","unstructured":"Kubagawa H, Honjo K, Ohkura N, Sakaguchi S, Radbruch A, Melchers F et al (2019) Functional roles of the IgM Fc receptor in the immune system. Front Immunol 10:945","journal-title":"Front Immunol"},{"issue":"4","key":"10472_CR71","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1136\/gut.42.4.522","volume":"42","author":"A Berstad","year":"1998","unstructured":"Berstad A, Brandtzaeg P (1998) Expression of cell membrane complement regulatory glycoproteins along the normal and diseased human gastrointestinal tract. Gut 42(4):522\u2013529","journal-title":"Gut"},{"issue":"3","key":"10472_CR72","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/cmi.2015.97","volume":"13","author":"Z Zhou","year":"2016","unstructured":"Zhou Z, Xu M-J, Gao B (2016) Hepatocytes: a key cell type for innate immunity. Cell Mol Immunol 13(3):301\u2013315","journal-title":"Cell Mol Immunol"},{"issue":"5","key":"10472_CR73","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/1529-0131(200105)44:5<997::AID-ANR178>3.0.CO;2-C","volume":"44","author":"ET Molenaar","year":"2001","unstructured":"Molenaar ET, Voskuyl AE, Familian A, van Mierlo GJ, Dijkmans BA, Hack CE (2001) Complement activation in patients with rheumatoid arthritis mediated in part by C-reactive protein. Arthritis Rheum 44(5):997\u20131002","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10472_CR74","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.addr.2007.07.003","volume":"59","author":"S Wirtz","year":"2007","unstructured":"Wirtz S, Neurath MF (2007) Mouse models of inflammatory bowel disease. Adv Drug Del Rev 59(11):1073\u20131083","journal-title":"Adv Drug Del Rev"},{"issue":"9","key":"10472_CR75","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1089\/jmf.2016.0020","volume":"19","author":"K Rtibi","year":"2016","unstructured":"Rtibi K, Selmi S, Jabri M-A, El-Benna J, Amri M, Marzouki L et al (2016) Protective effect of Ceratonia siliqua L. against a dextran sulfate sodium-induced alterations in liver and kidney in rat. J Med Food 19(9):882\u20139","journal-title":"J Med Food"},{"issue":"5","key":"10472_CR76","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.3390\/nu12051302","volume":"12","author":"A Bartoszek","year":"2020","unstructured":"Bartoszek A, Makaro A, Bartoszek A, Kordek R, Fichna J, Salaga M (2020) Walnut oil alleviates intestinal inflammation and restores intestinal barrier function in mice. Nutrients 12(5):1302","journal-title":"Nutrients"},{"key":"10472_CR77","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.aninu.2021.11.005","volume":"8","author":"M Akhtar","year":"2022","unstructured":"Akhtar M, Chen Y, Ma Z, Zhang X, Shi D, Khan JA et al (2022) Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation. Animal nutrition 8:350\u2013360","journal-title":"Animal nutrition"},{"key":"10472_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00535-016-1242-9","volume":"52","author":"M Sun","year":"2017","unstructured":"Sun M, Wu W, Liu Z, Cong Y (2017) Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases. J Gastroenterol 52:1\u20138","journal-title":"J Gastroenterol"},{"key":"10472_CR79","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.3389\/fimmu.2019.02754","volume":"10","author":"E Russo","year":"2019","unstructured":"Russo E, Giudici F, Fiorindi C, Ficari F, Scaringi S, Amedei A (2019) Immunomodulating activity and therapeutic effects of short chain fatty acids and tryptophan post-biotics in inflammatory bowel disease. Front Immunol 10:2754","journal-title":"Front Immunol"},{"key":"10472_CR80","doi-asserted-by":"crossref","unstructured":"Parada Venegas D, De la Fuente MK, Landskron G, Gonz\u00e1lez MJ, Quera R, Dijkstra G et al (2019) Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol 277:3310\u20133389","DOI":"10.3389\/fimmu.2019.01486"},{"key":"10472_CR81","doi-asserted-by":"crossref","unstructured":"Deleu S, Machiels K, Raes J, Verbeke K, Vermeire S (2021) Short chain fatty acids and its producing organisms: an overlooked therapy for IBD?. EBioMedicine 66","DOI":"10.1016\/j.ebiom.2021.103293"},{"issue":"20","key":"10472_CR82","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.3390\/nu15204466","volume":"15","author":"Y Shin","year":"2023","unstructured":"Shin Y, Han S, Kwon J, Ju S, Choi TG, Kang I et al (2023) Roles of short-chain fatty acids in inflammatory bowel disease. Nutrients 15(20):4466","journal-title":"Nutrients"},{"issue":"4","key":"10472_CR83","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.immuni.2015.09.014","volume":"43","author":"YD Bhutia","year":"2015","unstructured":"Bhutia YD, Ganapathy V (2015) Short, but smart: SCFAs train T cells in the gut to fight autoimmunity in the brain. Immunity 43(4):629\u2013631","journal-title":"Immunity"},{"issue":"1","key":"10472_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2020.1854675","volume":"62","author":"Y Yao","year":"2022","unstructured":"Yao Y, Cai X, Fei W, Ye Y, Zhao M, Zheng C (2022) The role of short-chain fatty acids in immunity, inflammation and metabolism. Crit Rev Food Sci Nutr 62(1):1\u201312","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"10472_CR85","doi-asserted-by":"publisher","first-page":"1968257","DOI":"10.1080\/19490976.2021.1968257","volume":"13","author":"G Li","year":"2021","unstructured":"Li G, Lin J, Zhang C, Gao H, Lu H, Gao X et al (2021) Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease. Gut microbes 13(1):1968257","journal-title":"Gut microbes"},{"issue":"9","key":"10472_CR86","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1111\/jgh.15970","volume":"37","author":"K Peng","year":"2022","unstructured":"Peng K, Xia S, Xiao S, Yu Q (2022) Short-chain fatty acids affect the development of inflammatory bowel disease through intestinal barrier, immunology, and microbiota: a promising therapy? J Gastroenterol Hepatol 37(9):1710\u20131718","journal-title":"J Gastroenterol Hepatol"},{"issue":"8","key":"10472_CR87","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.tim.2021.02.001","volume":"29","author":"B van der Hee","year":"2021","unstructured":"van der Hee B, Wells JM (2021) Microbial regulation of host physiology by short-chain fatty acids. Trends Microbiol 29(8):700\u2013712","journal-title":"Trends Microbiol"},{"key":"10472_CR88","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.intimp.2019.02.038","volume":"71","author":"S Shao","year":"2019","unstructured":"Shao S, Wang D, Zheng W, Li X, Zhang H, Zhao D et al (2019) A unique polysaccharide from Hericium erinaceus mycelium ameliorates acetic acid-induced ulcerative colitis rats by modulating the composition of the gut microbiota, short chain fatty acids levels and GPR41\/43 respectors. Int Immunopharmacol 71:411\u2013422","journal-title":"Int Immunopharmacol"},{"key":"10472_CR89","volume-title":"Inflammatory bowel disease, a dysregulated host-microbiota interaction: are probiotics a new therapeutic option?","author":"GS Howarth","year":"2008","unstructured":"Howarth GS (2008) Inflammatory bowel disease, a dysregulated host-microbiota interaction: are probiotics a new therapeutic option? Blackwell Publishing Asia, Melbourne, Australia"},{"key":"10472_CR90","doi-asserted-by":"publisher","first-page":"1126579","DOI":"10.3389\/fnut.2023.1126579","volume":"10","author":"S Ashique","year":"2023","unstructured":"Ashique S, Mishra N, Garg A, Sibuh BZ, Taneja P, Rai G et al (2023) Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis. Front Nutr 10:1126579","journal-title":"Front Nutr"},{"key":"10472_CR91","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jnutbio.2018.03.005","volume":"57","author":"Y Ren","year":"2018","unstructured":"Ren Y, Geng Y, Du Y, Li W, Lu Z-M, Xu H-Y et al (2018) Polysaccharide of Hericium erinaceus attenuates colitis in C57BL\/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota. J Nutr Biochem 57:67\u201376","journal-title":"J Nutr Biochem"},{"issue":"5","key":"10472_CR92","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1258\/ebm.2011.011358","volume":"237","author":"H Zhu","year":"2012","unstructured":"Zhu H, Li YR (2012) Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence. Exp Biol Med 237(5):474\u2013480","journal-title":"Exp Biol Med"},{"key":"10472_CR93","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3389\/fphys.2020.00694","volume":"11","author":"M Sharifi-Rad","year":"2020","unstructured":"Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E et al (2020) Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol 11:694","journal-title":"Front Physiol"},{"issue":"10","key":"10472_CR94","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.phymed.2016.06.010","volume":"23","author":"R Li","year":"2016","unstructured":"Li R, Chen Y, Shi M, Xu X, Zhao Y, Wu X et al (2016) Gegen Qinlian decoction alleviates experimental colitis via suppressing TLR4\/NF-\u03baB signaling and enhancing antioxidant effect. Phytomedicine 23(10):1012\u20131020","journal-title":"Phytomedicine"},{"issue":"9","key":"10472_CR95","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1111\/j.1463-1318.2008.01487.x","volume":"10","author":"Y Suzuki","year":"2008","unstructured":"Suzuki Y, Matsumoto T, Okamoto S, Hibi T (2008) A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis. Colorectal Dis 10(9):931\u2013934","journal-title":"Colorectal Dis"},{"issue":"3","key":"10472_CR96","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.3168\/jds.2018-15811","volume":"102","author":"S-T Ho","year":"2019","unstructured":"Ho S-T, Hsieh Y-T, Wang S-Y, Chen M-J (2019) Improving effect of a probiotic mixture on memory and learning abilities in D-galactose\u2013treated aging mice. J Dairy Sci 102(3):1901\u20131909","journal-title":"J Dairy Sci"},{"issue":"1","key":"10472_CR97","doi-asserted-by":"publisher","first-page":"9416794","DOI":"10.1155\/2021\/9416794","volume":"2021","author":"Y Pan","year":"2021","unstructured":"Pan Y, Ning Y, Hu J, Wang Z, Chen X, Zhao X (2021) The preventive effect of Lactobacillus plantarum ZS62 on DSS-Induced IBD by regulating oxidative stress and the immune response. Oxid Med Cell Longev 2021(1):9416794","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10472_CR98","first-page":"8030297","volume":"2021","author":"S Yao","year":"2021","unstructured":"Yao S, Zhao Z, Wang W, Liu X (2021) Bifidobacterium longum: protection against inflammatory bowel disease. J Immunol Res 2021(1):8030297","journal-title":"J Immunol Res"},{"issue":"1","key":"10472_CR99","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s12088-023-01140-2","volume":"64","author":"NE Al-Hazmi","year":"2024","unstructured":"Al-Hazmi NE, Naguib DM (2024) Antioxidant and antibacterial activities of nano-probiotics versus free probiotics against gastrointestinal pathogenic bacteria. Indian J Microbiol 64(1):141\u2013152","journal-title":"Indian J Microbiol"},{"issue":"5","key":"10472_CR100","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","volume":"14","author":"MF Neurath","year":"2014","unstructured":"Neurath MF (2014) Cytokines in inflammatory bowel disease. Nat Rev Immunol 14(5):329\u2013342","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10472_CR101","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1053\/j.gastro.2011.02.016","volume":"140","author":"W Strober","year":"2011","unstructured":"Strober W, Fuss IJ (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140(6):1756\u201367.e1","journal-title":"Gastroenterology"},{"issue":"2","key":"10472_CR102","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1365-3083.2006.01782.x","volume":"64","author":"A Corthay","year":"2006","unstructured":"Corthay A (2006) A three-cell model for activation of naive T helper cells. Scand J Immunol 64(2):93\u201396","journal-title":"Scand J Immunol"},{"issue":"12","key":"10472_CR103","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.3382\/ps.2009-00291","volume":"88","author":"K Sato","year":"2009","unstructured":"Sato K, Takahashi K, Tohno M, Miura Y, Kamada T, Ikegami S et al (2009) Immunomodulation in gut-associated lymphoid tissue of neonatal chicks by immunobiotic diets. Poult Sci 88(12):2532\u20132538","journal-title":"Poult Sci"},{"issue":"33","key":"10472_CR104","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.3748\/wjg.v25.i33.4796","volume":"25","author":"E Tourkochristou","year":"2019","unstructured":"Tourkochristou E, Aggeletopoulou I, Konstantakis C, Triantos C (2019) Role of NLRP3 inflammasome in inflammatory bowel diseases. World J Gastroenterol 25(33):4796","journal-title":"World J Gastroenterol"},{"key":"10472_CR105","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3389\/fimmu.2019.00276","volume":"10","author":"Y Zhen","year":"2019","unstructured":"Zhen Y, Zhang H (2019) NLRP3 inflammasome and inflammatory bowel disease. Front Immunol 10:276","journal-title":"Front Immunol"},{"issue":"2","key":"10472_CR106","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.intimp.2015.10.024","volume":"29","author":"G-D Kang","year":"2015","unstructured":"Kang G-D, Lim S, Kim D-H (2015) Oleanolic acid ameliorates dextran sodium sulfate-induced colitis in mice by restoring the balance of Th17\/Treg cells and inhibiting NF-\u03baB signaling pathway. Int Immunopharmacol 29(2):393\u2013400","journal-title":"Int Immunopharmacol"},{"issue":"46","key":"10472_CR107","doi-asserted-by":"publisher","first-page":"80790","DOI":"10.18632\/oncotarget.20477","volume":"8","author":"J-H Tao","year":"2017","unstructured":"Tao J-H, Duan J-A, Jiang S, Feng N-N, Qiu W-Q, Ling Y (2017) Polysaccharides from Chrysanthemum morifolium Ramat ameliorate colitis rats by modulating the intestinal microbiota community. Oncotarget 8(46):80790","journal-title":"Oncotarget"},{"issue":"9","key":"10472_CR108","doi-asserted-by":"publisher","first-page":"e22496","DOI":"10.1096\/fj.202200749R","volume":"36","author":"S Cavalu","year":"2022","unstructured":"Cavalu S, Sharaf H, Saber S, Youssef ME, Abdelhamid AM, Mourad AA et al (2022) Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-\u03baB, and decreases the susceptibility of the inflamed rat colon to apoptosis: a new treatment option for treating ulcerative colitis. FASEB J 36(9):e22496","journal-title":"FASEB J"},{"issue":"7351","key":"10472_CR109","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10208","volume":"474","author":"KJ Maloy","year":"2011","unstructured":"Maloy KJ, Powrie F (2011) Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474(7351):298\u2013306","journal-title":"Nature"},{"issue":"6","key":"10472_CR110","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.coph.2009.06.022","volume":"9","author":"KL Edelblum","year":"2009","unstructured":"Edelblum KL, Turner JR (2009) The tight junction in inflammatory disease: communication breakdown. Curr Opin Pharmacol 9(6):715\u2013720","journal-title":"Curr Opin Pharmacol"},{"key":"10472_CR111","doi-asserted-by":"crossref","first-page":"105390","DOI":"10.1016\/j.jff.2022.105390","volume":"100","author":"C Zhao","year":"2023","unstructured":"Zhao C, Jiang Y, Yin H, Jin Z, Yuan J, Shang H et al (2023) Hericium caput-medusae (Bull.: Fr.) Pers Fermentation concentrate polysaccharide ameliorate diarrhea in DSS-induced early colitis by modulating ion channel. J Funct Foods 100:105390","journal-title":"J Funct Foods"},{"issue":"3","key":"10472_CR112","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1053\/gast.2001.27224","volume":"121","author":"K Madsen","year":"2001","unstructured":"Madsen K, Cornish A, Soper P, McKaigney C, Jijon H, Yachimec C et al (2001) Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 121(3):580\u2013591","journal-title":"Gastroenterology"},{"issue":"4","key":"10472_CR113","first-page":"453","volume":"31","author":"P Gupta","year":"2000","unstructured":"Gupta P, Andrew H, Kirschner BS, Guandalini S (2000) Is Lactobacillus GG helpful in children with Crohn\u2019s disease? Results of a preliminary, open-label study. J Pediatr Gastroenterol Nutr 31(4):453\u2013457","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10472_CR114","doi-asserted-by":"publisher","first-page":"G851","DOI":"10.1152\/ajpgi.00327.2009","volume":"298","author":"J Karczewski","year":"2010","unstructured":"Karczewski J, Troost FJ, Konings I, Dekker J, Kleerebezem M, Brummer R-JM et al (2010) Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol-Gastrointest Liver Physiol 298(6):G851\u2013G9","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"issue":"10","key":"10472_CR115","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ni.3273","volume":"16","author":"ST Shibutani","year":"2015","unstructured":"Shibutani ST, Saitoh T, Nowag H, M\u00fcnz C, Yoshimori T (2015) Autophagy and autophagy-related proteins in the immune system. Nat Immunol 16(10):1014\u20131024","journal-title":"Nat Immunol"},{"issue":"33","key":"10472_CR116","doi-asserted-by":"publisher","first-page":"20511","DOI":"10.1074\/jbc.M114.632257","volume":"290","author":"K Tsuboi","year":"2015","unstructured":"Tsuboi K, Nishitani M, Takakura A, Imai Y, Komatsu M, Kawashima H (2015) Autophagy protects against colitis by the maintenance of normal gut microflora and secretion of mucus. J Biol Chem 290(33):20511\u201320526","journal-title":"J Biol Chem"},{"issue":"1","key":"10472_CR117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12957-016-0946-x","volume":"14","author":"KJ Schmitz","year":"2016","unstructured":"Schmitz KJ, Ademi C, Bertram S, Schmid KW, Baba HA (2016) Prognostic relevance of autophagy-related markers LC3, p62\/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. World J Surg Oncol 14(1):1\u201313","journal-title":"World J Surg Oncol"},{"issue":"3","key":"10472_CR118","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1158\/1078-0432.CCR-13-2438","volume":"21","author":"M Cicchini","year":"2015","unstructured":"Cicchini M, Karantza V, Xia B (2015) Molecular pathways: autophagy in cancer\u2014a matter of timing and context. Clin Cancer Res 21(3):498\u2013504","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10472_CR119","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1152\/ajpcell.00507.2009","volume":"298","author":"M Mehrpour","year":"2010","unstructured":"Mehrpour M, Esclatine A, Beau I, Codogno P (2010) Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview. Am J Physiol-Cell Physiol 298(4):776\u201385","journal-title":"Am J Physiol-Cell Physiol"},{"issue":"1","key":"10472_CR120","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1038\/s41598-020-58177-2","volume":"10","author":"SS Baji\u0107","year":"2020","unstructured":"Baji\u0107 SS, \u0110oki\u0107 J, Dini\u0107 M, Tomi\u0107 S, Popovi\u0107 N, Brdari\u0107 E et al (2020) GABA potentiate the immunoregulatory effects of Lactobacillus brevis BGZLS10-17 via ATG5-dependent autophagy in vitro. Sci Rep 10(1):1347","journal-title":"Sci Rep"},{"issue":"4","key":"10472_CR121","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s12088-015-0542-8","volume":"55","author":"VI Moroeanu","year":"2015","unstructured":"Moroeanu VI, Vamanu E, Paun G, Neagu E, Ungureanu OR, Eremia SA et al (2015) Probiotic strains influence on infant microbiota in the in vitro colonic fermentation model GIS1. Indian J Microbiol 55(4):423\u2013429","journal-title":"Indian J Microbiol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10472-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10472-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10472-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:03:06Z","timestamp":1763647386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10472-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,3]]},"references-count":121,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10472"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10472-y","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,3]]},"assertion":[{"value":"21 January 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}