{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:07:32Z","timestamp":1774350452048,"version":"3.50.1"},"reference-count":406,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s12602-025-10577-4","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T09:44:39Z","timestamp":1753091079000},"page":"2973-3009","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly"],"prefix":"10.1007","volume":"18","author":[{"given":"Neeraj","family":"Choudhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devesh","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Fazel","family":"Nabavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon","family":"Habtemariam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Isachesku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Berindan-Neagoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Azam","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farheen Badrealam","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Akli","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"issue":"12","key":"10577_CR1","doi-asserted-by":"publisher","first-page":"4590","DOI":"10.1002\/bit.27948","volume":"118","author":"S Parhi","year":"2021","unstructured":"Parhi S, Pal S, Das SK, Ghosh P (2021) Strategies toward development of antimicrobial biomaterials for dental healthcare applications. Biotechnol Bioeng 118(12):4590\u20134622. https:\/\/doi.org\/10.1002\/bit.27948","journal-title":"Biotechnol Bioeng"},{"key":"10577_CR2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.14744\/EEJ.2020.73626","volume":"5","author":"M Barbosa-Ribeiro","year":"2020","unstructured":"Barbosa-Ribeiro M, Arruda-Vasconcelos R, Louzada LM, Lima AR, Marciano MA, Almeida JFA, Dejesus-Soares A, Zaia AA, Ferraz CCR, Gomes BPFA (2020) Microbiological investigation in teeth with persistent\/secondary endodontic infection in different stages of root canal retreatment. Eur. Endod. J. 5:219\u2013225. https:\/\/doi.org\/10.14744\/EEJ.2020.73626","journal-title":"Eur. Endod. J."},{"key":"10577_CR3","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s40496-017-0161-z","volume":"4","author":"IF Persoon","year":"2017","unstructured":"Persoon IF, \u00d6zok AR (2017) Definitions and epidemiology of endodontic infections. Curr Oral Health Rep 4:278\u2013285. https:\/\/doi.org\/10.1007\/s40496-017-0161-z","journal-title":"Curr Oral Health Rep"},{"key":"10577_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1807-3107bor-2017.vol31.0108","volume":"31","author":"M Pourhajibagher","year":"2017","unstructured":"Pourhajibagher M, Ghorbanzadeh R, Bahador A (2017) Culture-dependent approaches to explore the prevalence of root canal pathogens from endodontic infections. Braz Oral Res 31:1\u20137. https:\/\/doi.org\/10.1590\/1807-3107bor-2017.vol31.0108","journal-title":"Braz Oral Res"},{"issue":"1","key":"10577_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cden.2016.08.001","volume":"61","author":"AF Fouad","year":"2017","unstructured":"Fouad AF (2017) Endodontic microbiology and pathobiology: current state of knowledge. Dent Clin 61(1):1\u201315. https:\/\/doi.org\/10.1016\/j.cden.2016.08.001","journal-title":"Dent Clin"},{"issue":"1","key":"10577_CR6","doi-asserted-by":"publisher","first-page":"6657167","DOI":"10.1155\/2021\/6657167","volume":"2021","author":"MI Karobari","year":"2021","unstructured":"Karobari MI, Maqbool M, Ahmad P, Abdul MS, Marya A, Venugopal A, Shaik GM, Scardina GA, Messina P, Noorani TY (2021) Endodontic microbiology: a bibliometric analysis of the top 50 classics. BioMed Res Int 2021(1):6657167. https:\/\/doi.org\/10.1155\/2021\/6657167","journal-title":"BioMed Res Int"},{"key":"10577_CR7","doi-asserted-by":"publisher","first-page":"233","DOI":"10.4103\/0972-0707.73386","volume":"13","author":"Ll Narayanan","year":"2010","unstructured":"Narayanan Ll, Vaishnavi C (2010) Endodontic microbiology. J Conserv Dent 13:233. https:\/\/doi.org\/10.4103\/0972-0707.73386","journal-title":"J Conserv Dent"},{"issue":"1","key":"10577_CR8","doi-asserted-by":"publisher","first-page":"6667624","DOI":"10.1155\/2021\/6667624","volume":"2021","author":"H Ahmadi","year":"2021","unstructured":"Ahmadi H, Ebrahimi A, Ahmadi F (2021) Antibiotic therapy in dentistry. Int J Dent 2021(1):6667624. https:\/\/doi.org\/10.1155\/2021\/6667624","journal-title":"Int J Dent"},{"key":"10577_CR9","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.4103\/jfmpc.jfmpc_768_19","volume":"8","author":"R Bansal","year":"2019","unstructured":"Bansal R, Jain A, Goyal M, Singh T, Sood H, Malviya H (2019) Antibiotic abuse during endodontic treatment: a contributing factor to antibiotic resistance. J Fam Med Prim Care 8:3518. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_768_19","journal-title":"J Fam Med Prim Care"},{"key":"10577_CR10","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.joen.2011.06.028","volume":"37","author":"GB Jungermann","year":"2011","unstructured":"Jungermann GB, Burns K, Nandakumar R, Tolba M, Venezia RA, Fouad AF (2011) Antibiotic resistance in primary and persistent endodontic infections. J Endod 37:1337\u20131344. https:\/\/doi.org\/10.1016\/j.joen.2011.06.028","journal-title":"J Endod"},{"key":"10577_CR11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ddtec.2014.02.003","volume":"11","author":"A Jolivet-Gougeon","year":"2014","unstructured":"Jolivet-Gougeon A, Bonnaure-Mallet M (2014) Biofilms as a mechanism of bacterial resistance. Drug Discov Today: Technol 11:49\u201356. https:\/\/doi.org\/10.1016\/j.ddtec.2014.02.003","journal-title":"Drug Discov Today: Technol"},{"issue":"1","key":"10577_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/antibiotics10010003","volume":"10","author":"C Uru\u00e9n","year":"2020","unstructured":"Uru\u00e9n C, Chopo-Escuin G, Tommassen J, Mainar-Jaime RC, Arenas J (2020) Biofilms as promoters of bacterial antibiotic resistance and tolerance. Antibiotics 10(1):3. https:\/\/doi.org\/10.3390\/antibiotics10010003","journal-title":"Antibiotics"},{"key":"10577_CR13","doi-asserted-by":"publisher","first-page":"170666","DOI":"10.1016\/j.peptides.2021.170666","volume":"146","author":"Y Han","year":"2021","unstructured":"Han Y, Zhang M, Lai R, Zhang Z (2021) Chemical modifications to increase the therapeutic potential of antimicrobial peptides. Peptides 146:170666. https:\/\/doi.org\/10.1016\/j.peptides.2021.170666","journal-title":"Peptides"},{"issue":"7","key":"10577_CR14","first-page":"3919","volume":"11","author":"J Lei","year":"2019","unstructured":"Lei J, Sun L, Huang S, Zhu C, Li P, He J, Mackey V, Coy DH, He Q (2019) The antimicrobial peptides and their potential clinical applications. Am J Transl Res 11(7):3919","journal-title":"Am J Transl Res"},{"key":"10577_CR15","doi-asserted-by":"publisher","first-page":"11472","DOI":"10.1021\/acs.jmedchem.1c00795","volume":"64","author":"D Sand\u00edn","year":"2021","unstructured":"Sand\u00edn D, Valle J, Chaves-Arquero B, Prats-Ejarque G, Larrosa MN, Gonz\u00e1lez-L\u00f3pez JJ, Jim\u00e9nez M\u00c1, Boix E, Andreu D, Torrent M (2021) Rationally modified antimicrobial peptides from the N-terminal domain of human RNase 3 show exceptional serum stability. J Med Chem 64:11472\u201311482. https:\/\/doi.org\/10.1021\/acs.jmedchem.1c00795","journal-title":"J Med Chem"},{"key":"10577_CR16","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.3389\/fmicb.2019.01703","volume":"10","author":"LR Pizzolato-Cezar","year":"2019","unstructured":"Pizzolato-Cezar LR, Okuda-Shinagawa NM, Machini MT (2019) Combinatory therapy antimicrobial peptide-antibiotic to minimize the ongoing rise of resistance. Front Microbiol 10:1703. https:\/\/doi.org\/10.3389\/fmicb.2019.01703","journal-title":"Front Microbiol"},{"key":"10577_CR17","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.3389\/fmicb.2017.02409","volume":"8","author":"L Grassi","year":"2017","unstructured":"Grassi L, Maisetta G, Esin S, Batoni G (2017) Combination strategies to enhance the efficacy of antimicrobial peptides against bacterial biofilms. Front Microbiol 8:2409. https:\/\/doi.org\/10.3389\/fmicb.2017.02409","journal-title":"Front Microbiol"},{"issue":"3","key":"10577_CR18","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.3390\/ijms23031445","volume":"23","author":"M Akbarian","year":"2022","unstructured":"Akbarian M, Khani A, Eghbalpour S, Uversky VN (2022) Bioactive peptides: synthesis, sources, applications, and proposed mechanisms of action. Int J Mol Sci 23(3):1445. https:\/\/doi.org\/10.3390\/ijms23031445","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10577_CR19","doi-asserted-by":"publisher","first-page":"102129","DOI":"10.1155\/2015\/102129","volume":"2015","author":"CE Salas","year":"2015","unstructured":"Salas CE, Badillo-Corona JA, Ram\u00edrez-Sotelo G, Oliver-Salvador C (2015) Biologically active and antimicrobial peptides from plants. BioMed Res Int 2015(1):102129. https:\/\/doi.org\/10.1155\/2015\/102129","journal-title":"BioMed Res Int"},{"key":"10577_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9010024","author":"CH Chen","year":"2020","unstructured":"Chen CH, Lu TK (2020) Development and challenges of antimicrobial peptides for therapeutic applications. Antibiotics. https:\/\/doi.org\/10.3390\/antibiotics9010024","journal-title":"Antibiotics"},{"key":"10577_CR21","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1039\/d1tb02617h","volume":"10","author":"A Rai","year":"2022","unstructured":"Rai A, Ferr\u00e3o R, Palma P, Patricio T, Parreira P, Anes E, Tonda-Turo C, Martins MCL, Alves N, Ferreira L (2022) Antimicrobial peptide-based materials: opportunities and challenges. J Mater Chem B 10:2384\u20132429. https:\/\/doi.org\/10.1039\/d1tb02617h","journal-title":"J Mater Chem B"},{"issue":"9","key":"10577_CR22","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/antibiotics10091095","volume":"10","author":"M Rima","year":"2021","unstructured":"Rima M, Rima M, Fajloun Z, Sabatier JM, Bechinger B, Naas T (2021) Antimicrobial peptides: a potent alternative to antibiotics. Antibiotics 10(9):1095. https:\/\/doi.org\/10.3390\/antibiotics10091095","journal-title":"Antibiotics"},{"key":"10577_CR23","doi-asserted-by":"publisher","unstructured":"Sanjeevamuthu S, Shanmugam V, Vairamuthu R, Sundar JK (2019) Antimicrobial peptides. In: Biocidal Polymers. pp 263\u2013294. https:\/\/doi.org\/10.1515\/9783110639131-012","DOI":"10.1515\/9783110639131-012"},{"issue":"19","key":"10577_CR24","doi-asserted-by":"publisher","first-page":"7047","DOI":"10.3390\/ijms21197047","volume":"21","author":"K Browne","year":"2020","unstructured":"Browne K, Chakraborty S, Chen R, Willcox MD, Black DS, Walsh WR, Kumar N (2020) A new era of antibiotics: the clinical potential of antimicrobial peptides. Int J Mol Sci 21(19):7047. https:\/\/doi.org\/10.3390\/ijms21197047","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10577_CR25","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3390\/molecules27041343","volume":"27","author":"G L\u00f3pez-Garc\u00eda","year":"2022","unstructured":"L\u00f3pez-Garc\u00eda G, Dublan-Garc\u00eda O, Arizmendi-Cotero D, G\u00f3mez Oliv\u00e1n LM (2022) Antioxidant and antimicrobial peptides derived from food proteins. Molecules 27(4):1343. https:\/\/doi.org\/10.3390\/molecules27041343","journal-title":"Molecules"},{"key":"10577_CR26","doi-asserted-by":"publisher","first-page":"668632","DOI":"10.3389\/fcimb.2021.668632","volume":"11","author":"A Moretta","year":"2021","unstructured":"Moretta A, Scieuzo C, Petrone AM, Salvia R, Manniello MD, Franco A, Lucchetti D, Vassallo A, Vogel H, Sgambato A, Falabella P (2021) Antimicrobial peptides: a new hope in biomedical and pharmaceutical fields. Front Cell Infect Microbiol 11:668632. https:\/\/doi.org\/10.3389\/fcimb.2021.668632","journal-title":"Front Cell Infect Microbiol"},{"key":"10577_CR27","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.3389\/fmicb.2019.02866","volume":"10","author":"N Raheem","year":"2019","unstructured":"Raheem N, Straus SK (2019) Mechanisms of action for antimicrobial peptides with antibacterial and antibiofilm functions. Front Microbiol 10:2866. https:\/\/doi.org\/10.3389\/fmicb.2019.02866","journal-title":"Front Microbiol"},{"issue":"3","key":"10577_CR28","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jsps.2018.01.001","volume":"26","author":"MH Semreen","year":"2018","unstructured":"Semreen MH, El-Gamal MI, Abdin S, Alkhazraji H, Kamal L, Hammad S, El-Awady F, Waleed D, Kourbaj L (2018) Recent updates of marine antimicrobial peptides. Saudi Pharm J 26(3):396\u2013409. https:\/\/doi.org\/10.1016\/j.jsps.2018.01.001","journal-title":"Saudi Pharm J"},{"issue":"1","key":"10577_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.biotechadv.2014.10.013","volume":"33","author":"SM de Freitas Lima","year":"2015","unstructured":"de Freitas Lima SM, de P\u00e1dua GM, da Costa Sousa MG, de Souza Freire M, Franco OL, Rezende TMB (2015) Antimicrobial peptide-based treatment for endodontic infections\u2014Biotechnological innovation in endodontics. Biotechnol Adv 33(1):203\u2013213. https:\/\/doi.org\/10.1016\/j.biotechadv.2014.10.013","journal-title":"Biotechnol Adv"},{"issue":"1","key":"10577_CR30","doi-asserted-by":"publisher","first-page":"9746720","DOI":"10.1155\/2017\/9746720","volume":"2017","author":"X Wang","year":"2017","unstructured":"Wang X, Yu H, Xing R, Li P (2017) Characterization, preparation, and purification of marine bioactive peptides. BioMed Res Int 2017(1):9746720. https:\/\/doi.org\/10.1155\/2017\/9746720","journal-title":"BioMed Res Int"},{"issue":"4","key":"10577_CR31","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s12393-012-9058-8","volume":"4","author":"J Carrasco-Castilla","year":"2012","unstructured":"Carrasco-Castilla J, Hern\u00e1ndez-\u00c1lvarez AJ, Jim\u00e9nez-Mart\u00ednez C, Guti\u00e9rrez-L\u00f3pez GF, D\u00e1vila-Ortiz G (2012) Use of proteomics and peptidomics methods in food bioactive peptide science and engineering. Food Eng. Rev 4(4):224\u2013243. https:\/\/doi.org\/10.1007\/s12393-012-9058-8","journal-title":"Food Eng. Rev"},{"issue":"11","key":"10577_CR32","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.3390\/nu10111738","volume":"10","author":"S Chakrabarti","year":"2018","unstructured":"Chakrabarti S, Guha S, Majumder K (2018) Food-derived bioactive peptides in human health: challenges and opportunities. Nutrients 10(11):1738. https:\/\/doi.org\/10.3390\/nu10111738","journal-title":"Nutrients"},{"key":"10577_CR33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.foodres.2015.05.013","volume":"74","author":"RJS de Castro","year":"2015","unstructured":"de Castro RJS, Sato HH (2015) Biologically active peptides: processes for their generation, purification and identification and applications as natural additives in the food and pharmaceutical industries. Food Res Int 74:185\u2013198. https:\/\/doi.org\/10.1016\/j.foodres.2015.05.013","journal-title":"Food Res Int"},{"issue":"1","key":"10577_CR34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/fqsafe\/fyx006","volume":"1","author":"A S\u00e1nchez","year":"2017","unstructured":"S\u00e1nchez A, V\u00e1zquez A (2017) Bioactive peptides: a review. Food Qual Saf 1(1):29\u201346. https:\/\/doi.org\/10.1093\/fqsafe\/fyx006","journal-title":"Food Qual Saf"},{"key":"10577_CR35","doi-asserted-by":"publisher","first-page":"815640","DOI":"10.3389\/fnut.2021.815640","volume":"8","author":"AA Zaky","year":"2022","unstructured":"Zaky AA, Simal-Gandara J, Eun JB, Shim JH, Abd El-Aty AM (2022) Bioactivities, applications, safety, and health benefits of bioactive peptides from food and by-products: a review. Front Nutr 8:815640. https:\/\/doi.org\/10.3389\/fnut.2021.815640","journal-title":"Front Nutr"},{"issue":"6","key":"10577_CR36","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s13205-021-02811-x","volume":"11","author":"N Choudhary","year":"2021","unstructured":"Choudhary N, Khatik GL, Sharma R, Khurana N, Lobo R, Bhatt S, Tewari D, Suttee A (2021) Ameliorative potential of Operculina turpethum against streptozotocin-induced diabetes in rats: biochemical and histopathological studies. 3 Biotech. 11(6):309. https:\/\/doi.org\/10.1007\/s13205-021-02811-x","journal-title":"3 Biotech."},{"key":"10577_CR37","doi-asserted-by":"publisher","first-page":"681","DOI":"10.15517\/am.v32i2.41437","volume":"32","author":"M Montero-Barrantes","year":"2021","unstructured":"Montero-Barrantes M (2021) Protein hydrolyzed from byproducts of the fishery industry: obtaining and functionality. Agron Mesoamerican 32:681\u2013699. https:\/\/doi.org\/10.15517\/am.v32i2.41437","journal-title":"Agron Mesoamerican"},{"key":"10577_CR38","doi-asserted-by":"crossref","unstructured":"Tewari D, Patni P, Bishayee, Anusha, Sah AN, Bishayee, Anupam (2022) Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: a novel therapeutic strategy. In: Seminars in Cancer Biology. Academic Press, pp 1\u201317","DOI":"10.1016\/j.semcancer.2019.12.008"},{"key":"10577_CR39","doi-asserted-by":"publisher","first-page":"102036","DOI":"10.1016\/j.pdpdt.2020.102036","volume":"32","author":"F Afkhami","year":"2020","unstructured":"Afkhami F, Karimi M, Bahador A, Ahmadi P, Pourhajibagher M, Chiniforush N (2020) Evaluation of antimicrobial photodynamic therapy with toluidine blue against Enterococcus faecalis: Laser vs LED. Photodiagnosis Photodyn Ther 32:102036. https:\/\/doi.org\/10.1016\/j.pdpdt.2020.102036","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10577_CR40","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jff.2013.01.012","volume":"5","author":"D Chen","year":"2013","unstructured":"Chen D, Liu Z, Huang W, Zhao Y, Dong S, Zeng M (2013) Purification and characterisation of a zinc-binding peptide from oyster protein hydrolysate. J Funct Foods 5:689\u2013697. https:\/\/doi.org\/10.1016\/j.jff.2013.01.012","journal-title":"J Funct Foods"},{"issue":"5","key":"10577_CR41","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3390\/biom11050631","volume":"11","author":"SH Peighambardoust","year":"2021","unstructured":"Peighambardoust SH, Karami Z, Pateiro M, Lorenzo JM (2021) A review on health-promoting, biological, and functional aspects of bioactive peptides in food applications. Biomolecules 11(5):631. https:\/\/doi.org\/10.3390\/biom11050631","journal-title":"Biomolecules"},{"issue":"4","key":"10577_CR42","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3390\/fermentation5040096","volume":"5","author":"D Tagliazucchi","year":"2019","unstructured":"Tagliazucchi D, Martini S, Solieri L (2019) Bioprospecting for bioactive peptide production by lactic acid bacteria isolated from fermented dairy food. Fermentation 5(4):96. https:\/\/doi.org\/10.3390\/fermentation5040096","journal-title":"Fermentation"},{"key":"10577_CR43","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1080\/10498850.2013.797534","volume":"24","author":"SF Deraz","year":"2015","unstructured":"Deraz SF (2015) Protein hydrolysate from visceral waste proteins of Bolti fish (Tilapia nilotica): chemical and nutritional variations as affected by processing pHs and time of hydrolysis. J Aquat Food Prod Technol 24:614\u2013631. https:\/\/doi.org\/10.1080\/10498850.2013.797534","journal-title":"J Aquat Food Prod Technol"},{"issue":"6","key":"10577_CR44","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1002\/med.21579","volume":"39","author":"KR Rengasamy","year":"2019","unstructured":"Rengasamy KR, Khan H, Ahmad I, Lobine D, Mahomoodally F, Suroowan S, Hassan ST, Xu S, Patel S, Daglia M, Nabavi SM (2019) Bioactive peptides and proteins as alternative antiplatelet drugs. Med Res Rev 39(6):2153\u20132171. https:\/\/doi.org\/10.1002\/med.21579","journal-title":"Med Res Rev"},{"issue":"2","key":"10577_CR45","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3390\/molecules23020307","volume":"23","author":"E Pogorzelska-Nowicka","year":"2018","unstructured":"Pogorzelska-Nowicka E, Atanasov AG, Horba\u0144czuk J, Wierzbicka A (2018) Bioactive compounds in functional meat products. Molecules 23(2):307. https:\/\/doi.org\/10.3390\/molecules23020307","journal-title":"Molecules"},{"key":"10577_CR46","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.meatsci.2012.02.007","volume":"91","author":"E Escudero","year":"2012","unstructured":"Escudero E, Toldr\u00e1 F, Sentandreu MA, Nishimura H, Arihara K (2012) Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat. Meat Sci 91:382\u2013384. https:\/\/doi.org\/10.1016\/j.meatsci.2012.02.007","journal-title":"Meat Sci"},{"key":"10577_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/md20080466","volume":"20","author":"S Ahmed","year":"2022","unstructured":"Ahmed S, Alam W, Jeandet P, Aschner M, Alsharif KF, Saso L, Khan H (2022) Therapeutic potential of marine peptides in prostate cancer: mechanistic insights. Mar Drugs 20:1\u201318. https:\/\/doi.org\/10.3390\/md20080466","journal-title":"Mar Drugs"},{"key":"10577_CR48","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1039\/c4fo00621f","volume":"6","author":"J Borawska","year":"2015","unstructured":"Borawska J, Darewicz M, Vegarud GE, Iwaniak A, Minkiewicz P (2015) Ex vivo digestion of carp muscle tissue - ACE inhibitory and antioxidant activities of the obtained hydrolysates. Food Funct 6:210\u2013217. https:\/\/doi.org\/10.1039\/c4fo00621f","journal-title":"Food Funct"},{"key":"10577_CR49","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.foodchem.2013.12.074","volume":"154","author":"H Jiang","year":"2014","unstructured":"Jiang H, Tong T, Sun J, Xu Y, Zhao Z, Liao D (2014) Purification and characterization of antioxidative peptides from round scad (Decapterus maruadsi) muscle protein hydrolysate. Food Chem 154:158\u2013163. https:\/\/doi.org\/10.1016\/j.foodchem.2013.12.074","journal-title":"Food Chem"},{"key":"10577_CR50","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jfca.2015.08.007","volume":"44","author":"AL Capriotti","year":"2015","unstructured":"Capriotti AL, Caruso G, Cavaliere C, Samperi R, Ventura S, Zenezini Chiozzi R, Lagan\u00e0 A (2015) Identification of potential bioactive peptides generated by simulated gastrointestinal digestion of soybean seeds and soy milk proteins. J Food Compos Anal 44:205\u2013213. https:\/\/doi.org\/10.1016\/j.jfca.2015.08.007","journal-title":"J Food Compos Anal"},{"key":"10577_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/s40529-021-00312-x","author":"J Li","year":"2021","unstructured":"Li J, Hu S, Jian W, Xie C, Yang X (2021) Plant antimicrobial peptides: structures, functions, and applications. Bot Stud. https:\/\/doi.org\/10.1186\/s40529-021-00312-x","journal-title":"Bot Stud"},{"key":"10577_CR52","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.3389\/fmicb.2016.02136","volume":"7","author":"BT Meneguetti","year":"2017","unstructured":"Meneguetti BT, Machado LDS, Oshiro KG, Nogueira ML, Carvalho CM, Franco OL (2017) Antimicrobial peptides from fruits and their potential use as biotechnological tools\u2014a review and outlook. Front Microbiol 7:2136. https:\/\/doi.org\/10.3389\/fmicb.2016.02136","journal-title":"Front Microbiol"},{"issue":"4","key":"10577_CR53","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/ph8040711","volume":"8","author":"JP Tam","year":"2015","unstructured":"Tam JP, Wang S, Wong KH, Tan WL (2015) Antimicrobial peptides from plants. Pharmaceuticals 8(4):711\u2013757. https:\/\/doi.org\/10.3390\/ph8040711","journal-title":"Pharmaceuticals"},{"key":"10577_CR54","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3389\/fmicb.2017.00592","volume":"8","author":"S Garrigues","year":"2017","unstructured":"Garrigues S, Gand\u00eda M, Borics A, Marx F, Manzanares P, Marcos JF (2017) Mapping and identification of antifungal peptides in the putative antifungal protein AfpB from the filamentous fungus Penicillium digitatum. Front Microbiol 8:592. https:\/\/doi.org\/10.3389\/fmicb.2017.00592","journal-title":"Front Microbiol"},{"key":"10577_CR55","doi-asserted-by":"publisher","unstructured":"Mart\u00ednez-Medina GA, Barrag\u00e1n AP, Ruiz HA, Ilyina A, Hern\u00e1ndez JLM, Rodr\u00edguez-Jasso RM, Hoyos-Concha JL, Aguilar-Gonz\u00e1lez CN (2018) Fungal proteases and production of bioactive peptides for the food industry. In: Enzymes in Food Biotechnology: Production, Applications, and Future Prospects. pp 221\u2013246. https:\/\/doi.org\/10.1016\/B978-0-12-813280-7.00014-1","DOI":"10.1016\/B978-0-12-813280-7.00014-1"},{"key":"10577_CR56","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1021\/acschembio.0c00794","volume":"16","author":"TD Vo","year":"2021","unstructured":"Vo TD, Spahn C, Heilemann M, Bode HB (2021) Microbial cationic peptides as a natural defense mechanism against insect antimicrobial peptides. ACS Chem Biol 16:447\u2013451. https:\/\/doi.org\/10.1021\/acschembio.0c00794","journal-title":"ACS Chem Biol"},{"issue":"5","key":"10577_CR57","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/md19050270","volume":"19","author":"T Fang","year":"2021","unstructured":"Fang T, Zhang X, Hu S, Yu Y, Sun X, Xu N (2021) Enzymatic degradation of gracilariopsis lemaneiformis polysaccharide and the antioxidant activity of its degradation products. Mar Drugs 19(5):270. https:\/\/doi.org\/10.3390\/md19050270","journal-title":"Mar Drugs"},{"key":"10577_CR58","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.foodres.2013.08.027","volume":"54","author":"A Alem\u00e1n","year":"2013","unstructured":"Alem\u00e1n A, G\u00f3mez-Guill\u00e9n MC, Montero P (2013) Identification of ace-inhibitory peptides from squid skin collagen after in vitro gastrointestinal digestion. Food Res Int 54:790\u2013795. https:\/\/doi.org\/10.1016\/j.foodres.2013.08.027","journal-title":"Food Res Int"},{"key":"10577_CR59","first-page":"903","volume":"26","author":"NM Sarbon","year":"2019","unstructured":"Sarbon NM, Howell NK, Wan Ahmad WAN (2019) Angiotensin-I converting enzyme (ACE) inhibitory peptides from chicken skin gelatin hydrolysate and its antihypertensive effect in spontaneously hypertensive rats. Int Food Res J 26:903\u2013911","journal-title":"Int Food Res J"},{"key":"10577_CR60","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s13197-010-0115-0","volume":"48","author":"Q Sun","year":"2011","unstructured":"Sun Q, Shen H, Luo Y (2011) Antioxidant activity of hydrolysates and peptide fractions derived from porcine hemoglobin. J Food Sci Technol 48:53\u201360. https:\/\/doi.org\/10.1007\/s13197-010-0115-0","journal-title":"J Food Sci Technol"},{"key":"10577_CR61","doi-asserted-by":"publisher","first-page":"831","DOI":"10.5851\/kosfa.2015.35.6.831","volume":"35","author":"YW Park","year":"2015","unstructured":"Park YW, Nam MS (2015) Bioactive peptides in milk and dairy products: a review. Korean J Food Sci Anim Resour 35:831\u2013840. https:\/\/doi.org\/10.5851\/kosfa.2015.35.6.831","journal-title":"Korean J Food Sci Anim Resour"},{"key":"10577_CR62","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/10408398.2015.1136590","volume":"58","author":"S Sultan","year":"2018","unstructured":"Sultan S, Huma N, Butt MS, Aleem M, Abbas M (2018) Therapeutic potential of dairy bioactive peptides: a contemporary perspective. Crit Rev Food Sci Nutr 58:105\u2013115. https:\/\/doi.org\/10.1080\/10408398.2015.1136590","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10577_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/ph15020222","author":"D Al Shaer","year":"2022","unstructured":"Al Shaer D, Al Musaimi O, Albericio F, de la Torre BG (2022) 2021 FDA TIDES (peptides and oligonucleotides) harvest. Pharmaceuticals. https:\/\/doi.org\/10.3390\/ph15020222","journal-title":"Pharmaceuticals"},{"issue":"1\u20132","key":"10577_CR64","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.drudis.2009.10.009","volume":"15","author":"P Vlieghe","year":"2010","unstructured":"Vlieghe P, Lisowski V, Martinez J, Khrestchatisky M (2010) Synthetic therapeutic peptides: science and market. Drug Discov Today 15(1\u20132):40\u201356. https:\/\/doi.org\/10.1016\/j.drudis.2009.10.009","journal-title":"Drug Discov Today"},{"issue":"2","key":"10577_CR65","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1177\/1091581820977846","volume":"40","author":"D Zane","year":"2021","unstructured":"Zane D, Feldman PL, Sawyer T, Sobol Z, Hawes J (2021) Development and regulatory challenges for peptide therapeutics. Int J Toxicol 40(2):10\u2013124. https:\/\/doi.org\/10.1177\/1091581820977846","journal-title":"Int J Toxicol"},{"issue":"4","key":"10577_CR66","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.3390\/molecules18044373","volume":"18","author":"S Chandrudu","year":"2013","unstructured":"Chandrudu S, Simerska P, Toth I (2013) Chemical methods for peptide and protein production. Molecules 18(4):4373\u20134388. https:\/\/doi.org\/10.3390\/molecules18044373","journal-title":"Molecules"},{"key":"10577_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-62703-544-6_1","volume":"1047","author":"KJ Jensen","year":"2013","unstructured":"Jensen KJ (2013) Solid-phase peptide synthesis: an introduction. Methods Mol Biol 1047:1\u201321. https:\/\/doi.org\/10.1007\/978-1-62703-544-6_1","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10577_CR68","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/17518253.2021.1877363","volume":"14","author":"K Wegner","year":"2021","unstructured":"Wegner K, Barnes D, Manzor K, Jardine A, Moran D (2021) Evaluation of greener solvents for solid-phase peptide synthesis. Green Chem Lett Rev 14(1):153\u2013164. https:\/\/doi.org\/10.1080\/17518253.2021.1877363","journal-title":"Green Chem Lett Rev"},{"key":"10577_CR69","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1021\/acs.joc.8b03001","volume":"84","author":"A Isidro-Llobet","year":"2019","unstructured":"Isidro-Llobet A, Kenworthy MN, Mukherjee S, Kopach ME, Wegner K, Gallou F, Smith AG, Roschangar F (2019) Sustainability challenges in peptide synthesis and purification: From R&D to Production. J Org Chem 84:4615\u20134628. https:\/\/doi.org\/10.1021\/acs.joc.8b03001","journal-title":"J Org Chem"},{"issue":"1","key":"10577_CR70","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/psc.2836","volume":"22","author":"R Behrendt","year":"2016","unstructured":"Behrendt R, White P, Offer J (2016) Advances in Fmoc solid-phase peptide synthesis. J Pept Sci 22(1):4\u201327. https:\/\/doi.org\/10.1002\/psc.2836","journal-title":"J Pept Sci"},{"issue":"62","key":"10577_CR71","doi-asserted-by":"publisher","first-page":"32658","DOI":"10.1039\/c4ra02458c","volume":"4","author":"JM Palomo","year":"2014","unstructured":"Palomo JM (2014) Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides. Rsc Adv 4(62):32658\u201332672. https:\/\/doi.org\/10.1039\/c4ra02458c","journal-title":"Rsc Adv"},{"issue":"11","key":"10577_CR72","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.3390\/molecules23112877","volume":"23","author":"YF Varela","year":"2018","unstructured":"Varela YF, Vanegas Murcia M, Patarroyo ME (2018) Synthetic evaluation of standard and microwave-assisted solid phase peptide synthesis of a long chimeric peptide derived from four Plasmodium falciparum proteins. Molecules 23(11):2877. https:\/\/doi.org\/10.3390\/molecules23112877","journal-title":"Molecules"},{"key":"10577_CR73","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201801807","author":"KG Varnava","year":"2019","unstructured":"Varnava KG, Sarojini V (2019) Making solid-phase peptide synthesis greener: a review of the literature. Chem - An Asian J. https:\/\/doi.org\/10.1002\/asia.201801807","journal-title":"Chem - An Asian J"},{"key":"10577_CR74","doi-asserted-by":"publisher","first-page":"5362","DOI":"10.1016\/j.matpr.2021.01.947","volume":"45","author":"N Choudhary","year":"2021","unstructured":"Choudhary N, Chatterjee M, Kumar S, Singh G, Suttee A (2021a) Effect of conventional method and microwave assisted extraction on phytoconstituents of Chenopodium album. Mater Today: Proc 45:5362\u20135367. https:\/\/doi.org\/10.1016\/j.matpr.2021.01.947","journal-title":"Mater Today: Proc"},{"key":"10577_CR75","doi-asserted-by":"publisher","first-page":"151","DOI":"10.13982\/j.mfst.1673-9078.2015.4.024","volume":"31","author":"B Hu","year":"2015","unstructured":"Hu B, Fan DM, Wusgal, Lian HZ, Zhang H, Chen W (2015) The radical production and oxidative properties of rice protein under microwave radiatio. Mod. Food Sci. Technol. 31:151\u2013156. https:\/\/doi.org\/10.13982\/j.mfst.1673-9078.2015.4.024","journal-title":"Mod. Food Sci. Technol."},{"key":"10577_CR76","doi-asserted-by":"publisher","unstructured":"Hussein WM, Skwarczynski M, Toth I (2020) An isodipeptide building block for microwave-assisted solid-phase synthesis of difficult sequence-containing peptides. In: Methods in Molecular Biology. pp 139\u2013150. https:\/\/doi.org\/10.1007\/978-1-0716-0227-0_9","DOI":"10.1007\/978-1-0716-0227-0_9"},{"key":"10577_CR77","doi-asserted-by":"publisher","first-page":"8034","DOI":"10.1021\/acssuschemeng.8b01531","volume":"6","author":"A Kumar","year":"2018","unstructured":"Kumar A, Jad YE, Collins JM, Albericio F, De La Torre BG (2018) Microwave-assisted green solid-phase peptide synthesis using \u03b3-valerolactone (GVL) as solvent. ACS Sustain Chem Eng 6:8034\u20138039. https:\/\/doi.org\/10.1021\/acssuschemeng.8b01531","journal-title":"ACS Sustain Chem Eng"},{"issue":"8","key":"10577_CR78","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.21608\/EJCHEM.2019.7119.1611","volume":"62","author":"S Osman","year":"2019","unstructured":"Osman S, Jones S, Zewail M, Rabie A, Shalaby A, Howl J (2019) Microwave assisted peptide synthesis of some rationally designed cell penetrating peptides from c-kit receptor. Egypt J Chem 62(8):1377\u20131389. https:\/\/doi.org\/10.21608\/EJCHEM.2019.7119.1611","journal-title":"Egypt J Chem"},{"key":"10577_CR79","doi-asserted-by":"publisher","unstructured":"Kremsmayr T, Muttenthaler M (2022) Fmoc solid phase peptide synthesis of oxytocin and analogues. In: Methods in Molecular Biology. pp 175\u2013199. https:\/\/doi.org\/10.1007\/978-1-0716-1759-5_11","DOI":"10.1007\/978-1-0716-1759-5_11"},{"key":"10577_CR80","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1055\/s-0036-1589037","volume":"28","author":"P Sun","year":"2017","unstructured":"Sun P, Tang W, Huang Y, Hu BH (2017) Improved Fmoc solid-phase peptide synthesis of oxytocin with high bioactivity. Synlett 28:1780\u20131784. https:\/\/doi.org\/10.1055\/s-0036-1589037","journal-title":"Synlett"},{"key":"10577_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.02123-20","volume":"11","author":"GB De Cesare","year":"2020","unstructured":"De Cesare GB, Cristy SA, Garsin DA, Lorenz MC (2020) Antimicrobial peptides: a new frontier in antifungal therapy. MBio 11:1\u201321. https:\/\/doi.org\/10.1128\/mBio.02123-20","journal-title":"MBio"},{"issue":"3","key":"10577_CR82","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/omi.12333","volume":"36","author":"JY Niu","year":"2021","unstructured":"Niu JY, Yin IX, Mei ML, Wu WKK, Li QL, Chu CH (2021) The multifaceted roles of antimicrobial peptides in oral diseases. Mol Oral Microbiol 36(3):159\u2013171. https:\/\/doi.org\/10.1111\/omi.12333","journal-title":"Mol Oral Microbiol"},{"key":"10577_CR83","doi-asserted-by":"publisher","unstructured":"Bruggeman M, Ijakipour H, Stamboulis A (2019) Defensin-like peptides and their antimicrobial activity in free-form and immobilized on material surfaces. In: Peptide Synthesis. https:\/\/doi.org\/10.5772\/intechopen.85508","DOI":"10.5772\/intechopen.85508"},{"issue":"4","key":"10577_CR84","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/ja.2013.138","volume":"67","author":"N Singh","year":"2014","unstructured":"Singh N, Abraham J (2014) Ribosomally synthesized peptides from natural sources. J Antibiot (Tokyo) 67(4):277\u2013289. https:\/\/doi.org\/10.1038\/ja.2013.138","journal-title":"J Antibiot (Tokyo)"},{"key":"10577_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40508-016-0057-6","volume":"4","author":"MA Mart\u00ednez-N\u00fa\u00f1ez","year":"2016","unstructured":"Mart\u00ednez-N\u00fa\u00f1ez MA, L\u00f3pez VELY (2016) Nonribosomal peptides synthetases and their applications in industry. Sustain Chem Proc 4:1\u20138. https:\/\/doi.org\/10.1186\/s40508-016-0057-6","journal-title":"Sustain Chem Proc"},{"key":"10577_CR86","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3389\/fcimb.2016.00194","volume":"6","author":"M Mahlapuu","year":"2016","unstructured":"Mahlapuu M, H\u00e5kansson J, Ringstad L, Bj\u00f6rn C (2016) Antimicrobial peptides: an emerging category of therapeutic agents. Front Cell Infect Microbiol 6:194. https:\/\/doi.org\/10.3389\/fcimb.2016.00194","journal-title":"Front Cell Infect Microbiol"},{"key":"10577_CR87","doi-asserted-by":"publisher","first-page":"4349","DOI":"10.1007\/s13197-020-04915-3","volume":"58","author":"U Mohanty","year":"2021","unstructured":"Mohanty U, Majumdar RK, Mohanty B, Mehta NK, Parhi J (2021) Influence of the extent of enzymatic hydrolysis on the functional properties of protein hydrolysates from visceral waste of Labeo rohita. J Food Sci Technol 58:4349\u20134358. https:\/\/doi.org\/10.1007\/s13197-020-04915-3","journal-title":"J Food Sci Technol"},{"issue":"16","key":"10577_CR88","doi-asserted-by":"publisher","first-page":"7108","DOI":"10.1039\/d1fo01265g","volume":"12","author":"L Jia","year":"2021","unstructured":"Jia L, Wang L, Liu C, Liang Y, Lin Q (2021) Bioactive peptides from foods: production, function, and application. Food Funct 12(16):7108\u20137125. https:\/\/doi.org\/10.1039\/d1fo01265g","journal-title":"Food Funct"},{"key":"10577_CR89","doi-asserted-by":"publisher","first-page":"100183","DOI":"10.1016\/j.fochx.2021.100183","volume":"13","author":"A Peredo-Lovillo","year":"2022","unstructured":"Peredo-Lovillo A, Hern\u00e1ndez-Mendoza A, Vallejo-Cordoba B, Romero-Luna HE (2022) Conventional and in silico approaches to select promising food-derived bioactive peptides: a review. Food Chem: X 13:100183. https:\/\/doi.org\/10.1016\/j.fochx.2021.100183","journal-title":"Food Chem: X"},{"issue":"2","key":"10577_CR90","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jff.2009.01.007","volume":"1","author":"H Korhonen","year":"2009","unstructured":"Korhonen H (2009) Milk-derived bioactive peptides: from science to applications. J Funct Foods 1(2):177\u2013187. https:\/\/doi.org\/10.1016\/j.jff.2009.01.007","journal-title":"J Funct Foods"},{"issue":"5","key":"10577_CR91","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.sjbs.2015.06.005","volume":"23","author":"DP Mohanty","year":"2016","unstructured":"Mohanty DP, Mohapatra S, Misra S, Sahu DP (2016) Milk derived bioactive peptides and their impact on human health\u2013A review. Saudi J Biol Sci 23(5):577\u2013583. https:\/\/doi.org\/10.1016\/j.sjbs.2015.06.005","journal-title":"Saudi J Biol Sci"},{"key":"10577_CR92","doi-asserted-by":"publisher","first-page":"100771","DOI":"10.1016\/j.fbio.2020.100771","volume":"38","author":"SK Shivanna","year":"2020","unstructured":"Shivanna SK, Nataraj BH (2020) Revisiting therapeutic and toxicological fingerprints of milk-derived bioactive peptides: an overview. Food Biosci 38:100771. https:\/\/doi.org\/10.1016\/j.fbio.2020.100771","journal-title":"Food Biosci"},{"key":"10577_CR93","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1016\/j.procbio.2012.08.019","volume":"47","author":"CB Ahn","year":"2012","unstructured":"Ahn CB, Jeon YJ, Kim YT, Je JY (2012) Angiotensin i converting enzyme (ACE) inhibitory peptides from salmon byproduct protein hydrolysate by Alcalase hydrolysis. Process Biochem 47:2240\u20132245. https:\/\/doi.org\/10.1016\/j.procbio.2012.08.019","journal-title":"Process Biochem"},{"key":"10577_CR94","doi-asserted-by":"publisher","first-page":"e20201636","DOI":"10.1590\/0001-3765202220201636","volume":"94","author":"AP De Amorim","year":"2022","unstructured":"De Amorim AP, Da Silva GH, Brand\u00e3o RMP, Porto ALF, Bezerra RP (2022) Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review. An Acad Bras Cienc 94:e20201636. https:\/\/doi.org\/10.1590\/0001-3765202220201636","journal-title":"An Acad Bras Cienc"},{"key":"10577_CR95","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.idairyj.2005.03.010","volume":"16","author":"S Roufik","year":"2006","unstructured":"Roufik S, Gauthier SF, Turgeon SL (2006) In vitro digestibility of bioactive peptides derived from bovine \u03b2-lactoglobulin. Int Dairy J 16:294\u2013302. https:\/\/doi.org\/10.1016\/j.idairyj.2005.03.010","journal-title":"Int Dairy J"},{"issue":"7","key":"10577_CR96","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3390\/foods9070846","volume":"9","author":"A Jakubczyk","year":"2020","unstructured":"Jakubczyk A, Kara\u015b M, Rybczy\u0144ska-Tkaczyk K, Zieli\u0144ska E, Zieli\u0144ski D (2020) Current trends of bioactive peptides\u2014New sources and therapeutic effect. Foods 9(7):846. https:\/\/doi.org\/10.3390\/foods9070846","journal-title":"Foods"},{"issue":"4\u20135","key":"10577_CR97","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1051\/lait:2007019","volume":"87","author":"I L\u00f3pez-Exp\u00f3sito","year":"2007","unstructured":"L\u00f3pez-Exp\u00f3sito I, Quir\u00f3s A, Amigo L, Recio I (2007) Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides. Lait 87(4\u20135):241\u2013249. https:\/\/doi.org\/10.1051\/lait:2007019","journal-title":"Lait"},{"issue":"5","key":"10577_CR98","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/foods6050032","volume":"6","author":"EBM Daliri","year":"2017","unstructured":"Daliri EBM, Oh DH, Lee BH (2017) Bioactive peptides. Foods 6(5):32. https:\/\/doi.org\/10.3390\/foods6050032","journal-title":"Foods"},{"key":"10577_CR99","doi-asserted-by":"publisher","unstructured":"Barberis SE, Origone AL, Adaro MO, Bersi G (2018) Bioactive peptides as functional food ingredients. In: Role of Materials Science in Food Bioengineering. pp 147\u2013186. https:\/\/doi.org\/10.1016\/B978-0-12-811448-3.00005-X","DOI":"10.1016\/B978-0-12-811448-3.00005-X"},{"key":"10577_CR100","doi-asserted-by":"publisher","unstructured":"Mine Y, Li-Chan E, Jiang B (2010) Bioactive proteins and peptides as functional foods and nutraceuticals, bioactive proteins and peptides as functional foods and nutraceuticals. https:\/\/doi.org\/10.1002\/9780813811048","DOI":"10.1002\/9780813811048"},{"key":"10577_CR101","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1039\/c9fo01293a","volume":"11","author":"AI Mulet-Cabero","year":"2020","unstructured":"Mulet-Cabero AI, Egger L, Portmann R, M\u00e9nard O, Marze S, Minekus M, Le Feunteun S, Sarkar A, Grundy MML, Carri\u00e8re F, Golding M, Dupont D, Recio I, Brodkorb A, Mackie A (2020) A standardised semi-dynamic: in vitro digestion method suitable for food-an international consensus. Food Funct 11:1702\u20131720. https:\/\/doi.org\/10.1039\/c9fo01293a","journal-title":"Food Funct"},{"key":"10577_CR102","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1007\/s11694-018-9833-1","volume":"12","author":"L Najafian","year":"2018","unstructured":"Najafian L, Babji AS (2018) Fractionation and identification of novel antioxidant peptides from fermented fish (pekasam). J Food Meas Charact 12:2174\u20132183. https:\/\/doi.org\/10.1007\/s11694-018-9833-1","journal-title":"J Food Meas Charact"},{"key":"10577_CR103","doi-asserted-by":"publisher","first-page":"e13620","DOI":"10.1111\/jfpp.13620","volume":"42","author":"SR Subin","year":"2018","unstructured":"Subin SR, Mohan A, Khiari Z, Udenigwe CC, Mason B (2018) Yield, physicochemical, and antioxidant properties of Atlantic salmon visceral hydrolysate: comparison of lactic acid bacterial fermentation with Flavourzyme proteolysis and formic acid treatment. J Food Process Preserv 42:e13620. https:\/\/doi.org\/10.1111\/jfpp.13620","journal-title":"J Food Process Preserv"},{"key":"10577_CR104","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3934\/microbiol.2018.4.665","volume":"4","author":"T Bintsis","year":"2018","unstructured":"Bintsis T (2018) Lactic acid bacteria as starter cultures: an update in their metabolism and genetics. AIMS Microbiol 4:665\u2013684. https:\/\/doi.org\/10.3934\/microbiol.2018.4.665","journal-title":"AIMS Microbiol"},{"issue":"1","key":"10577_CR105","doi-asserted-by":"publisher","first-page":"608979","DOI":"10.1155\/2014\/608979","volume":"2014","author":"S Chakrabarti","year":"2014","unstructured":"Chakrabarti S, Jahandideh F, Wu J (2014) Food-derived bioactive peptides on inflammation and oxidative stress. BioMed Res Int 2014(1):608979. https:\/\/doi.org\/10.1155\/2014\/608979","journal-title":"BioMed Res Int"},{"key":"10577_CR106","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.3389\/fmicb.2018.02354","volume":"9","author":"C Raveschot","year":"2018","unstructured":"Raveschot C, Cudennec B, Coutte F, Flahaut C, Fremont M, Drider D, Dhulster P (2018) Production of bioactive peptides by lactobacillus species: from gene to application. Front Microbiol 9:2354. https:\/\/doi.org\/10.3389\/fmicb.2018.02354","journal-title":"Front Microbiol"},{"issue":"2","key":"10577_CR107","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3390\/nu12020425","volume":"12","author":"K D\u2019Souza","year":"2020","unstructured":"D\u2019Souza K, Mercer A, Mawhinney H, Pulinilkunnil T, Udenigwe CC, Kienesberger PC (2020) Whey peptides stimulate differentiation and lipid metabolism in adipocytes and ameliorate lipotoxicity-induced insulin resistance in muscle cells. Nutrients 12(2):425. https:\/\/doi.org\/10.3390\/nu12020425","journal-title":"Nutrients"},{"issue":"4","key":"10577_CR108","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/fermentation6040106","volume":"6","author":"R Sharma","year":"2020","unstructured":"Sharma R, Garg P, Kumar P, Bhatia SK, Kulshrestha S (2020) Microbial fermentation and its role in quality improvement of fermented foods. Fermentation 6(4):106. https:\/\/doi.org\/10.3390\/fermentation6040106","journal-title":"Fermentation"},{"key":"10577_CR109","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1365-2672.2006.03072.x","volume":"102","author":"T Virtanen","year":"2007","unstructured":"Virtanen T, Pihlanto A, Akkanen S, Korhonen H (2007) Development of antioxidant activity in milk whey during fermentation with lactic acid bacteria. J Appl Microbiol 102:106\u2013115. https:\/\/doi.org\/10.1111\/j.1365-2672.2006.03072.x","journal-title":"J Appl Microbiol"},{"issue":"1","key":"10577_CR110","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/1568026615666150703120753","volume":"16","author":"R Zhang","year":"2016","unstructured":"Zhang R, Eckert T, Lutteke T, Hanstein S, Scheidig A, MJJ Bonvin A, E Nifantiev N, Kozar T, Schauer R, Abdulaziz Enani M, Siebert HC (2015) Structure-function relationships of antimicrobial peptides and proteins with respect to contact molecules on pathogen surfaces. Curr Top Med Chem 16(1):89\u201398","journal-title":"Curr Top Med Chem"},{"key":"10577_CR111","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1089\/mdr.2017.0392","volume":"24","author":"H Moravej","year":"2018","unstructured":"Moravej H, Moravej Z, Yazdanparast M, Heiat M, Mirhosseini A, Moosazadeh Moghaddam M, Mirnejad R (2018) Antimicrobial peptides: features, action, and their resistance mechanisms in bacteria. Microb Drug Resist 24:747\u2013767. https:\/\/doi.org\/10.1089\/mdr.2017.0392","journal-title":"Microb Drug Resist"},{"issue":"2","key":"10577_CR112","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3109\/07388551.2011.594423","volume":"32","author":"M Pasupuleti","year":"2012","unstructured":"Pasupuleti M, Schmidtchen A, Malmsten M (2012) Antimicrobial peptides: key components of the innate immune system. Crit Rev Biotechnol 32(2):143\u2013171. https:\/\/doi.org\/10.3109\/07388551.2011.594423","journal-title":"Crit Rev Biotechnol"},{"key":"10577_CR113","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/0929866526666190822165812","volume":"27","author":"JK Boparai","year":"2019","unstructured":"Boparai JK, Sharma PK (2019) Mini review on antimicrobial peptides, sources, mechanism and recent applications. Protein Pept Lett 27:4\u201316. https:\/\/doi.org\/10.2174\/0929866526666190822165812","journal-title":"Protein Pept Lett"},{"key":"10577_CR114","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.ejmech.2017.11.086","volume":"143","author":"M Je\u017cowska-Bojczuk","year":"2018","unstructured":"Je\u017cowska-Bojczuk M, Stokowa-So\u0142tys K (2018) Peptides having antimicrobial activity and their complexes with transition metal ions. Eur J Med Chem 143:997\u20131009. https:\/\/doi.org\/10.1016\/j.ejmech.2017.11.086","journal-title":"Eur J Med Chem"},{"key":"10577_CR115","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.foodres.2014.06.008","volume":"64","author":"L Jiang","year":"2014","unstructured":"Jiang L, Wang B, Li B, Wang C, Luo Y (2014) Preparation and identification of peptides and their zinc complexes with antimicrobial activities from silver carp (Hypophthalmichthys molitrix) protein hydrolysates. Food Res Int 64:91\u201398. https:\/\/doi.org\/10.1016\/j.foodres.2014.06.008","journal-title":"Food Res Int"},{"issue":"1","key":"10577_CR116","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1038\/srep01854","volume":"3","author":"B Ding","year":"2013","unstructured":"Ding B, Soblosky L, Nguyen K, Geng J, Yu X, Ramamoorthy A, Chen Z (2013) Physiologically-relevant modes of membrane interactions by the human antimicrobial peptide, LL-37, revealed by SFG experiments. Sci Rep 3(1):1854. https:\/\/doi.org\/10.1038\/srep01854","journal-title":"Sci Rep"},{"issue":"1","key":"10577_CR117","doi-asserted-by":"publisher","first-page":"16158","DOI":"10.1038\/s41598-018-34467-8","volume":"8","author":"U Gerstel","year":"2018","unstructured":"Gerstel U, Latendorf T, Bartels J, Becker A, Tholey A, Schr\u00f6der JM (2018) Hornerin contains a linked series of ribosome-targeting peptide antibiotics. Sci Rep 8(1):16158. https:\/\/doi.org\/10.1038\/s41598-018-34467-8","journal-title":"Sci Rep"},{"issue":"11","key":"10577_CR118","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3390\/toxins10110461","volume":"10","author":"Q Wu","year":"2018","unstructured":"Wu Q, Pato\u010dka J, Ku\u010da K (2018) Insect antimicrobial peptides, a mini review. Toxins (Basel) 10(11):461. https:\/\/doi.org\/10.3390\/toxins10110461","journal-title":"Toxins (Basel)"},{"key":"10577_CR119","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1080\/10408398.2015.1117412","volume":"57","author":"DC Dallas","year":"2017","unstructured":"Dallas DC, Sanctuary MR, Qu Y, Khajavi SH, Van Zandt AE, Dyandra M, Frese SA, Barile D, German JB (2017) Personalizing protein nourishment. Crit Rev Food Sci Nutr 57:3313\u20133331. https:\/\/doi.org\/10.1080\/10408398.2015.1117412","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10577_CR120","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1017\/S0022029907002609","volume":"74","author":"B Hern\u00e1ndez-Ledesma","year":"2007","unstructured":"Hern\u00e1ndez-Ledesma B, Miguel M, Amigo L, Aleixandre MA, Recio I (2007) Effect of simulated gastrointestinal digestion on the antihypertensive properties of synthetic \u03b2-lactoglobulin peptide sequences. J Dairy Res 74:336\u2013339. https:\/\/doi.org\/10.1017\/S0022029907002609","journal-title":"J Dairy Res"},{"key":"10577_CR121","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.2147\/IJN.S41521","volume":"8","author":"AA Khan","year":"2013","unstructured":"Khan AA, Mudassir J, Mohtar N, Darwis Y (2013) Advanced drug delivery to the lymphatic system: lipid-based nanoformulations. Int J Nanomed 8:2733\u20132744. https:\/\/doi.org\/10.2147\/IJN.S41521","journal-title":"Int J Nanomed"},{"key":"10577_CR122","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.physbeh.2011.04.056","volume":"105","author":"AB Kohan","year":"2011","unstructured":"Kohan AB, Yoder SM, Tso P (2011) Using the lymphatics to study nutrient absorption and the secretion of gastrointestinal hormones. Physiol Behav 105:82\u201388. https:\/\/doi.org\/10.1016\/j.physbeh.2011.04.056","journal-title":"Physiol Behav"},{"key":"10577_CR123","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.addr.2016.07.007","volume":"106","author":"P Lundquist","year":"2016","unstructured":"Lundquist P, Artursson P (2016) Oral absorption of peptides and nanoparticles across the human intestine: opportunities, limitations and studies in human tissues. Adv Drug Deliv Rev 106:256\u2013276. https:\/\/doi.org\/10.1016\/j.addr.2016.07.007","journal-title":"Adv Drug Deliv Rev"},{"issue":"1\u20132","key":"10577_CR124","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijpharm.2013.02.030","volume":"447","author":"J Renukuntla","year":"2013","unstructured":"Renukuntla J, Vadlapudi AD, Patel A, Boddu SH, Mitra AK (2013) Approaches for enhancing oral bioavailability of peptides and proteins. Int J Pharm 447(1\u20132):75\u201393. https:\/\/doi.org\/10.1016\/j.ijpharm.2013.02.030","journal-title":"Int J Pharm"},{"issue":"8","key":"10577_CR125","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1016\/j.apsb.2021.04.001","volume":"11","author":"Q Zhu","year":"2021","unstructured":"Zhu Q, Chen Z, Paul PK, Lu Y, Wu W, Qi J (2021) Oral delivery of proteins and peptides: challenges, status quo and future perspectives. Acta Pharm Sin B 11(8):2416\u20132448. https:\/\/doi.org\/10.1016\/j.apsb.2021.04.001","journal-title":"Acta Pharm Sin B"},{"key":"10577_CR126","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.aoas.2015.10.007","volume":"60","author":"SA Elsohaimy","year":"2015","unstructured":"Elsohaimy SA, Refaay TM, Zaytoun MAM (2015) Physicochemical and functional properties of quinoa protein isolate. Ann Agric Sci 60:297\u2013305. https:\/\/doi.org\/10.1016\/j.aoas.2015.10.007","journal-title":"Ann Agric Sci"},{"key":"10577_CR127","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/1541-4337.12135","volume":"14","author":"BL Graf","year":"2015","unstructured":"Graf BL, Rojas-Silva P, Rojo LE, Delatorre-Herrera J, Balde\u00f3n ME, Raskin I (2015) Innovations in health value and functional food development of quinoa (Chenopodium quinoa Willd.). Compr Rev Food Sci Food Saf 14:431\u2013445. https:\/\/doi.org\/10.1111\/1541-4337.12135","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"10577_CR128","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112275","author":"MM Abeer","year":"2021","unstructured":"Abeer MM, Trajkovic S, Brayden DJ (2021) Measuring the oral bioavailability of protein hydrolysates derived from food sources: a critical review of current bioassays. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2021.112275","journal-title":"Biomed Pharmacother"},{"issue":"19","key":"10577_CR129","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.3390\/molecules25194479","volume":"25","author":"L Amigo","year":"2020","unstructured":"Amigo L, Hern\u00e1ndez-Ledesma B (2020) Current evidence on the bioavailability of food bioactive peptides. Molecules 25(19):4479. https:\/\/doi.org\/10.3390\/molecules25194479","journal-title":"Molecules"},{"key":"10577_CR130","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.ijantimicag.2014.12.015","volume":"45","author":"C Bj\u00f6rn","year":"2015","unstructured":"Bj\u00f6rn C, Noppa L, N\u00e4slund Salomonsson E, Johansson AL, Nilsson E, Mahlapuu M, H\u00e5kansson J (2015) Efficacy and safety profile of the novel antimicrobial peptide PXL150 in a mouse model of infected burn wounds. Int J Antimicrob Agents 45:519\u2013524. https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.12.015","journal-title":"Int J Antimicrob Agents"},{"issue":"3","key":"10577_CR131","doi-asserted-by":"publisher","first-page":"e01318","DOI":"10.1128\/spectrum.01318-21","volume":"9","author":"J Chen","year":"2021","unstructured":"Chen J, Hao D, Mei K, Li X, Li T, Ma C, Xi X, Li L, Wang L, Zhou M, Chen T (2021) In Vitro and in vivo studies on the antibacterial activity and safety of a new antimicrobial peptide dermaseptin-AC. Microbiol Spectr 9(3):e01318-e1321. https:\/\/doi.org\/10.1128\/spectrum.01318-21","journal-title":"Microbiol Spectr"},{"key":"10577_CR132","doi-asserted-by":"publisher","unstructured":"Chen X, Chen, Xu, Han J, Wang S (2021) A review of antimicrobial peptides from marine fish and its potential application in food safety. Shipin Kexue\/Food Sci. https:\/\/doi.org\/10.7506\/spkx1002-6630-20200507-077","DOI":"10.7506\/spkx1002-6630-20200507-077"},{"issue":"18","key":"10577_CR133","doi-asserted-by":"publisher","first-page":"eaay6817","DOI":"10.1126\/sciadv.aay6817","volume":"6","author":"YP Di","year":"2020","unstructured":"Di YP, Lin Q, Chen C, Montelaro RC, Doi Y, Deslouches BJSA (2020) Enhanced therapeutic index of an antimicrobial peptide in mice by increasing safety and activity against multidrug-resistant bacteria. Sci Adv 6(18):eaay6817. https:\/\/doi.org\/10.1126\/sciadv.aay6817","journal-title":"Sci Adv"},{"issue":"12","key":"10577_CR134","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.3390\/ph6121543","volume":"6","author":"AA Bahar","year":"2013","unstructured":"Bahar AA, Ren D (2013) Antimicrobial peptides. Pharmaceuticals 6(12):1543\u20131575. https:\/\/doi.org\/10.3390\/ph6121543","journal-title":"Pharmaceuticals"},{"key":"10577_CR135","doi-asserted-by":"publisher","first-page":"31492","DOI":"10.1038\/srep31492","volume":"6","author":"J Singh","year":"2016","unstructured":"Singh J, Joshi S, Mumtaz S, Maurya N, Ghosh I, Khanna S, Natarajan VT, Mukhopadhyay K (2016) Enhanced cationic charge is a key factor in promoting staphylocidal activity of \u03b1-melanocyte stimulating hormone via selective lipid affinity. Sci Rep 6:31492. https:\/\/doi.org\/10.1038\/srep31492","journal-title":"Sci Rep"},{"key":"10577_CR136","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1093\/jac\/dkt322","volume":"69","author":"H Kim","year":"2014","unstructured":"Kim H, Jang JH, Kim SC, Cho JH (2014) De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. J Antimicrob Chemother 69:121\u2013132. https:\/\/doi.org\/10.1093\/jac\/dkt322","journal-title":"J Antimicrob Chemother"},{"key":"10577_CR137","doi-asserted-by":"publisher","first-page":"e3137","DOI":"10.1002\/psc.3137","volume":"25","author":"T Thery","year":"2019","unstructured":"Thery T, Shwaiki LN, O\u2019Callaghan YC, O\u2019Brien NM, Arendt EK (2019) Antifungal activity of a de novo synthetic peptide and derivatives against fungal food contaminants. J Pept Sci 25:e3137. https:\/\/doi.org\/10.1002\/psc.3137","journal-title":"J Pept Sci"},{"issue":"18","key":"10577_CR138","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1016\/j.jmb.2018.12.015","volume":"431","author":"MD Torres","year":"2019","unstructured":"Torres MD, Sothiselvam S, Lu TK, de la Fuente-Nunez C (2019) Peptide design principles for antimicrobial applications. J Mol Biol 431(18):3547\u20133567. https:\/\/doi.org\/10.1016\/j.jmb.2018.12.015","journal-title":"J Mol Biol"},{"key":"10577_CR139","doi-asserted-by":"publisher","first-page":"13206","DOI":"10.1038\/s41598-020-69995-9","volume":"10","author":"I Greco","year":"2020","unstructured":"Greco I, Molchanova N, Holmedal E, Jenssen H, Hummel BD, Watts JL, H\u00e5kansson J, Hansen PR, Svenson J (2020) Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides. Sci Rep 10:13206. https:\/\/doi.org\/10.1038\/s41598-020-69995-9","journal-title":"Sci Rep"},{"key":"10577_CR140","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1016\/j.fct.2010.04.016","volume":"48","author":"A Anad\u00f3n","year":"2010","unstructured":"Anad\u00f3n A, Mart\u00ednez MA, Ares I, Ramos E, Mart\u00ednez-Larra\u00f1aga MR, Contreras MM, Ramos M, Recio I (2010) Acute and repeated dose (4 weeks) oral toxicity studies of two antihypertensive peptides, RYLGY and AYFYPEL, that correspond to fragments (90\u201394) and (143\u2013149) from \u03b1s1-casein. Food Chem Toxicol 48:1836\u20131845. https:\/\/doi.org\/10.1016\/j.fct.2010.04.016","journal-title":"Food Chem Toxicol"},{"key":"10577_CR141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2891-9-52","volume":"9","author":"E Boelsma","year":"2010","unstructured":"Boelsma E, Kloek J (2010) IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial. Nutr J 9:1\u20137. https:\/\/doi.org\/10.1186\/1475-2891-9-52","journal-title":"Nutr J"},{"issue":"1","key":"10577_CR142","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10989-019-09823-5","volume":"26","author":"D Bhandari","year":"2020","unstructured":"Bhandari D, Rafiq S, Gat Y, Gat P, Waghmare R, Kumar V (2020) A review on bioactive peptides: physiological functions, bioavailability and safety. Int J Pept Res Ther 26(1):139\u2013150. https:\/\/doi.org\/10.1007\/s10989-019-09823-5","journal-title":"Int J Pept Res Ther"},{"key":"10577_CR143","doi-asserted-by":"publisher","first-page":"236","DOI":"10.2174\/1570163815666180219112806","volume":"15","author":"F Khan","year":"2018","unstructured":"Khan F, Niaz K, Abdollahi M (2018) Toxicity of biologically active peptides and future safety aspects: an update. Curr Drug Discov Technol 15:236\u2013242. https:\/\/doi.org\/10.2174\/1570163815666180219112806","journal-title":"Curr Drug Discov Technol"},{"key":"10577_CR144","doi-asserted-by":"publisher","unstructured":"Singh G, Paul RS, Arora A, Kumar S, Jindal L, Raina S (2020) Disease of pulp and periradicular tissue: an overview. J Curr Med Res Opin 3. https:\/\/doi.org\/10.15520\/jcmro.v3i10.351","DOI":"10.15520\/jcmro.v3i10.351"},{"key":"10577_CR145","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1002\/JLB.4MA0620-072RR","volume":"108","author":"MM Jones","year":"2020","unstructured":"Jones MM, Vanyo ST, Ibraheem W, Maddi A, Visser MB (2020) Treponema denticola stimulates Oncostatin M cytokine release and de novo synthesis in neutrophils and macrophages. J Leukoc Biol 108:1527\u20131541. https:\/\/doi.org\/10.1002\/JLB.4MA0620-072RR","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10577_CR146","doi-asserted-by":"publisher","first-page":"182513","DOI":"10.1155\/2014\/182513","volume":"2014","author":"YA AlJehani","year":"2014","unstructured":"AlJehani YA (2014) [Retracted] Risk factors of periodontal disease: review of the literature. Int J Dent 2014(1):182513. https:\/\/doi.org\/10.1155\/2014\/182513","journal-title":"Int J Dent"},{"issue":"1","key":"10577_CR147","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","volume":"42","author":"FQ Bui","year":"2019","unstructured":"Bui FQ, Almeida-da-Silva CL, Huynh B, Trinh A, Liu J, Woodward J, Asadi H, Ojcius DM (2019) Association between periodontal pathogens and systemic disease. Biomed J 42(1):27\u201335. https:\/\/doi.org\/10.1016\/j.bj.2018.12.001","journal-title":"Biomed J"},{"issue":"2","key":"10577_CR148","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/odi.13045","volume":"26","author":"M Jiang","year":"2020","unstructured":"Jiang M, Li Z, Zhu G (2020) The role of autophagy in the pathogenesis of periodontal disease. Oral Dis 26(2):259\u2013269. https:\/\/doi.org\/10.1111\/odi.13045","journal-title":"Oral Dis"},{"key":"10577_CR149","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1590\/1807-3107bor-2018.vol32.0069","volume":"32","author":"BPFDA Gomes","year":"2018","unstructured":"Gomes BPFDA, Herrera DR (2018) Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology. Braz Oral Res 32:82\u2013110. https:\/\/doi.org\/10.1590\/1807-3107bor-2018.vol32.0069","journal-title":"Braz Oral Res"},{"key":"10577_CR150","doi-asserted-by":"publisher","first-page":"672887","DOI":"10.3389\/froh.2021.672887","volume":"2","author":"J Wong","year":"2021","unstructured":"Wong J, Manoil D, N\u00e4sman P, Belibasakis GN, Neelakantan P (2021) Microbiological aspects of root canal infections and disinfection strategies: an update review on the current knowledge and challenges. Front Oral Health 2:672887. https:\/\/doi.org\/10.3389\/froh.2021.672887","journal-title":"Front Oral Health"},{"issue":"1","key":"10577_CR151","doi-asserted-by":"publisher","first-page":"230251","DOI":"10.1155\/2015\/230251","volume":"2015","author":"JC Farges","year":"2015","unstructured":"Farges JC, Alliot-Licht B, Renard E, Ducret M, Gaudin A, Smith AJ, Cooper PR (2015) Dental pulp defence and repair mechanisms in dental caries. Mediators Inflamm 2015(1):230251. https:\/\/doi.org\/10.1155\/2015\/230251","journal-title":"Mediators Inflamm"},{"issue":"4","key":"10577_CR152","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/femsre\/fuw007","volume":"40","author":"RF Maldonado","year":"2016","unstructured":"Maldonado RF, S\u00e1-Correia I, Valvano MA (2016) Lipopolysaccharide modification in gram-negative bacteria during chronic infection. FEMS Microbiol Rev 40(4):480\u2013493. https:\/\/doi.org\/10.1093\/femsre\/fuw007","journal-title":"FEMS Microbiol Rev"},{"issue":"5","key":"10577_CR153","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.ijmm.2016.03.001","volume":"306","author":"A Steimle","year":"2016","unstructured":"Steimle A, Autenrieth IB, Frick JS (2016) Structure and function: lipid A modifications in commensals and pathogens. Int J Med Microbiol 306(5):290\u2013301. https:\/\/doi.org\/10.1016\/j.ijmm.2016.03.001","journal-title":"Int J Med Microbiol"},{"issue":"4","key":"10577_CR154","doi-asserted-by":"publisher","first-page":"373","DOI":"10.18683\/germs.2023.1407","volume":"13","author":"A Gliga","year":"2023","unstructured":"Gliga A, S\u0103ndulescu M, Amza O, St\u0103nescu R, Imre M (2023) Dental pathologies of endodontic origin and subsequent bacterial involvement\u2013a literature review. Germs 13(4):373. https:\/\/doi.org\/10.18683\/germs.2023.1407","journal-title":"Germs"},{"key":"10577_CR155","doi-asserted-by":"publisher","first-page":"e364","DOI":"10.4317\/medoral.22907","volume":"24","author":"I Prada","year":"2019","unstructured":"Prada I, Mic\u00f3-Mu\u00f1oz P, Giner-Lluesma T, Mic\u00f3-Mart\u00ednez P, Collado-Castellano N, Manzano-Saiz A (2019) Influence of microbiology on endodontic failure. Literature review. Med Oral Patol Oral y Cir Bucal 24:e364\u2013e372. https:\/\/doi.org\/10.4317\/medoral.22907","journal-title":"Med Oral Patol Oral y Cir Bucal"},{"issue":"2","key":"10577_CR156","doi-asserted-by":"publisher","first-page":"54","DOI":"10.14744\/eej.2020.42714","volume":"5","author":"K Karamifar","year":"2020","unstructured":"Karamifar K, Tondari A, Saghiri MA (2020) Endodontic periapical lesion: an overview on the etiology, diagnosis and current treatment modalities. Eur Endod J 5(2):54. https:\/\/doi.org\/10.14744\/eej.2020.42714","journal-title":"Eur Endod J"},{"key":"10577_CR157","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.biopha.2018.01.146","volume":"99","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Wang X, Li H, Ni C, Du Z, Yan F (2018) Human oral microbiota and its modulation for oral health. Biomed Pharmacother 99:883\u2013893. https:\/\/doi.org\/10.1016\/j.biopha.2018.01.146","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10577_CR158","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.fshw.2018.12.001","volume":"8","author":"M Lu","year":"2019","unstructured":"Lu M, Xuan S, Wang Z (2019) Oral microbiota: a new view of body health. Food Sci Hum Wellness 8(1):8\u201315. https:\/\/doi.org\/10.1016\/j.fshw.2018.12.001","journal-title":"Food Sci Hum Wellness"},{"key":"10577_CR159","doi-asserted-by":"publisher","first-page":"629723","DOI":"10.3389\/fcimb.2021.629723","volume":"11","author":"M Lenartova","year":"2021","unstructured":"Lenartova M, Tesinska B, Janatova T, Hrebicek O, Mysak J, Janata J, Najmanova L (2021) The oral microbiome in periodontal health. Front Cell Infect Microbiol 11:629723. https:\/\/doi.org\/10.3389\/fcimb.2021.629723","journal-title":"Front Cell Infect Microbiol"},{"key":"10577_CR160","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/bs.aambs.2016.08.002","volume":"97","author":"B Sampaio-Maia","year":"2016","unstructured":"Sampaio-Maia B, Caldas IM, Pereira ML, P\u00e9rez-Mongiovi D, Araujo R (2016) The oral microbiome in health and its implication in oral and systemic diseases. Adv Appl Microbiol 97:171\u2013210. https:\/\/doi.org\/10.1016\/bs.aambs.2016.08.002","journal-title":"Adv Appl Microbiol"},{"issue":"4","key":"10577_CR161","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00203-018-1505-3","volume":"200","author":"D Verma","year":"2018","unstructured":"Verma D, Garg PK, Dubey AK (2018) Insights into the human oral microbiome. Arch Microbiol 200(4):525\u2013540. https:\/\/doi.org\/10.1007\/s00203-018-1505-3","journal-title":"Arch Microbiol"},{"key":"10577_CR162","first-page":"103","volume":"6","author":"M Javidi","year":"2011","unstructured":"Javidi M, Zarei M, Afkhami F (2011) Antibacterial effect of calcium hydroxide on intraluminal and intratubular Enterococcus faecalis. Iran Endod J 6:103\u2013106","journal-title":"Iran Endod J"},{"issue":"1","key":"10577_CR163","doi-asserted-by":"publisher","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","volume":"23","author":"PN Deo","year":"2019","unstructured":"Deo PN, Deshmukh R (2019) Oral microbiome: unveiling the fundamentals. J Oral Maxillofac Pathol 23(1):122\u2013128. https:\/\/doi.org\/10.4103\/jomfp.JOMFP_304_18","journal-title":"J Oral Maxillofac Pathol"},{"issue":"7","key":"10577_CR164","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.3390\/diagnostics11071283","volume":"11","author":"YH Lee","year":"2021","unstructured":"Lee YH, Chung SW, Auh QS, Hong SJ, Lee YA, Jung J, Lee GJ, Park HJ, Shin SI, Hong JY (2021) Progress in oral microbiome related to oral and systemic diseases: an update. Diagnostics 11(7):1283. https:\/\/doi.org\/10.3390\/diagnostics11071283","journal-title":"Diagnostics"},{"key":"10577_CR165","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12866-017-1064-9","volume":"17","author":"BA Peters","year":"2017","unstructured":"Peters BA, Wu J, Hayes RB, Ahn J (2017) The oral fungal mycobiome: characteristics and relation to periodontitis in a pilot study. BMC Microbiol 17:1\u201311. https:\/\/doi.org\/10.1186\/s12866-017-1064-9","journal-title":"BMC Microbiol"},{"key":"10577_CR166","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1080\/21505594.2021.1982373","volume":"12","author":"S Zhu","year":"2021","unstructured":"Zhu S, Viejo-Borbolla A (2021) Pathogenesis and virulence of herpes simplex virus. Virulence 12:2670\u20132702. https:\/\/doi.org\/10.1080\/21505594.2021.1982373","journal-title":"Virulence"},{"issue":"1","key":"10577_CR167","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s12105-019-01003-7","volume":"13","author":"SJ Betz","year":"2019","unstructured":"Betz SJ (2019) HPV-related papillary lesions of the oral mucosa: a review. Head Neck Pathol 13(1):80\u201390. https:\/\/doi.org\/10.1007\/s12105-019-01003-7","journal-title":"Head Neck Pathol"},{"issue":"1","key":"10577_CR168","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/adj.12020","volume":"58","author":"SR Prabhu","year":"2013","unstructured":"Prabhu SR, Wilson DF (2013) Human papillomavirus and oral disease\u2013emerging evidence: a review. Aust Dent J 58(1):2\u201310. https:\/\/doi.org\/10.1111\/adj.12020","journal-title":"Aust Dent J"},{"key":"10577_CR169","first-page":"43","volume":"27","author":"A Pakfetrat","year":"2015","unstructured":"Pakfetrat A, Falaki F, Delavarian Z, Dalirsani Z, Sanatkhani M, Marani MZ (2015) Oral manifestations of human immunodeficiency virus-infected patients. Iran J Otorhinolaryngol 27:43\u201354","journal-title":"Iran J Otorhinolaryngol"},{"key":"10577_CR170","doi-asserted-by":"publisher","unstructured":"Siqueira JF, R\u00f4\u00e7as IN (2019) Microbiology of apical periodontitis. In: Essential Endodontology: Prevention and Treatment of Apical Periodontitis. pp 91\u2013142. https:\/\/doi.org\/10.1002\/9781119272014.ch4","DOI":"10.1002\/9781119272014.ch4"},{"issue":"3","key":"10577_CR171","doi-asserted-by":"publisher","first-page":"1900060","DOI":"10.1002\/prca.201900060","volume":"14","author":"D Manoil","year":"2020","unstructured":"Manoil D, Al-Manei K, Belibasakis GN (2020) A systematic review of the root canal microbiota associated with apical periodontitis: lessons from next-generation sequencing. Proteomics-Clin Appl 14(3):1900060. https:\/\/doi.org\/10.1002\/prca.201900060","journal-title":"Proteomics-Clin Appl"},{"key":"10577_CR172","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/iej.13677","volume":"55","author":"JF Siqueira Jr","year":"2022","unstructured":"Siqueira JF Jr, R\u00f4\u00e7as IN (2022) Present status and future directions: microbiology of endodontic infections. Int Endod J 55:512\u2013530. https:\/\/doi.org\/10.1111\/iej.13677","journal-title":"Int Endod J"},{"key":"10577_CR173","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/00004770-200307000-00003","volume":"29","author":"JF Siqueira","year":"2003","unstructured":"Siqueira JF, R\u00f4\u00e7as IN (2003) Positive and negative bacterial associations involving Dialister pneumosintes in primary endodontic infections. J Endod 29:438\u2013441. https:\/\/doi.org\/10.1097\/00004770-200307000-00003","journal-title":"J Endod"},{"key":"10577_CR174","doi-asserted-by":"publisher","first-page":"155","DOI":"10.17796\/jcpd.38.2.5252712533082gt0","volume":"38","author":"N Topcuoglu","year":"2013","unstructured":"Topcuoglu N, Bozdo\u01e7an E, Aktoren O, Kulekci G (2013) Presence of oral bacterial species in primary endodontic infections of primary teeth. J Clin Pediatr Dent 38:155\u2013160. https:\/\/doi.org\/10.17796\/jcpd.38.2.5252712533082gt0","journal-title":"J Clin Pediatr Dent"},{"issue":"1","key":"10577_CR175","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1128\/mmbr.00037-15","volume":"80","author":"H Dang","year":"2016","unstructured":"Dang H, Lovell CR (2016) Microbial surface colonization and biofilm development in marine environments. Microbiol Mol Biol Rev 80(1):91\u2013138. https:\/\/doi.org\/10.1128\/mmbr.00037-15","journal-title":"Microbiol Mol Biol Rev"},{"issue":"2","key":"10577_CR176","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/dj7020047","volume":"7","author":"M Dioguardi","year":"2019","unstructured":"Dioguardi M, Di Gioia G, Illuzzi G, Arena C, Caponio VC, Caloro GA, Zhurakivska K, Adipietro I, Troiano G, Muzio, Lo L (2019) Inspection of the microbiota in endodontic lesions. Dent J 7(2):47. https:\/\/doi.org\/10.3390\/dj7020047","journal-title":"Dent J"},{"issue":"14","key":"10577_CR177","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.3390\/ijms20143423","volume":"20","author":"W Yin","year":"2019","unstructured":"Yin W, Wang Y, Liu L, He J (2019) Biofilms: the microbial \u201cprotective clothing\u201d in extreme environments. Int J Mol Sci 20(14):3423. https:\/\/doi.org\/10.3390\/ijms20143423","journal-title":"Int J Mol Sci"},{"key":"10577_CR178","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.3389\/fmicb.2018.02374","volume":"9","author":"S Bouillaguet","year":"2018","unstructured":"Bouillaguet S, Manoil D, Girard M, Louis J, Ga\u00efa N, Leo S, Schrenzel J, Lazarevic V (2018) Root microbiota in primary and secondary apical periodontitis. Front Microbiol 9:2374. https:\/\/doi.org\/10.3389\/fmicb.2018.02374","journal-title":"Front Microbiol"},{"key":"10577_CR179","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255003","author":"A Alberti","year":"2021","unstructured":"Alberti A, Corbella S, Taschieri S, Francetti L, Fakhruddin KS, Samaranayake LP (2021) Fungal species in endodontic infections: a systematic review and meta-analysis. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0255003","journal-title":"PLoS ONE"},{"key":"10577_CR180","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7257","author":"F Alghamdi","year":"2020","unstructured":"Alghamdi F, Shakir M (2020) The influence of Enterococcus faecalis as a dental root canal pathogen on endodontic treatment: a systematic review. Cureus. https:\/\/doi.org\/10.7759\/cureus.7257","journal-title":"Cureus"},{"issue":"11","key":"10577_CR181","doi-asserted-by":"publisher","first-page":"e49576","DOI":"10.1371\/journal.pone.0049576","volume":"7","author":"AC Anderson","year":"2012","unstructured":"Anderson AC, Hellwig E, Vespermann R, Wittmer A, Schmid M, Karygianni L, Al-Ahmad A (2012) Comprehensive analysis of secondary dental root canal infections: a combination of culture and culture-independent approaches reveals new insights. PLoS ONE 7(11):e49576. https:\/\/doi.org\/10.1371\/journal.pone.0049576","journal-title":"PLoS ONE"},{"key":"10577_CR182","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.joen.2017.03.019","volume":"43","author":"C Keskin","year":"2017","unstructured":"Keskin C, Demiry\u00fcrek E\u00d6, Onuk EE (2017) Pyrosequencing analysis of cryogenically ground samples from primary and secondary\/persistent endodontic infections. J Endod 43:1309\u20131316. https:\/\/doi.org\/10.1016\/j.joen.2017.03.019","journal-title":"J Endod"},{"key":"10577_CR183","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1399-302X.2007.00423.x","volume":"23","author":"M Sakamoto","year":"2008","unstructured":"Sakamoto M, Siqueira JFJ, R\u00f4\u00e7as IN, Benno Y (2008) Molecular analysis of the root canal microbiota associated with endodontic treatment failures. Oral Microbiol Immunol 23:275\u2013281. https:\/\/doi.org\/10.1111\/j.1399-302X.2007.00423.x","journal-title":"Oral Microbiol Immunol"},{"issue":"4","key":"10577_CR184","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/jicd.12045","volume":"5","author":"M Del Fabbro","year":"2014","unstructured":"Del Fabbro M, Samaranayake LP, Lolato A, Weinstein T, Taschieri S (2014) Analysis of the secondary endodontic lesions focusing on the extraradicular microorganisms: an overview. J Investig Clin Dent 5(4):245\u2013254. https:\/\/doi.org\/10.1111\/jicd.12045","journal-title":"J Investig Clin Dent"},{"key":"10577_CR185","doi-asserted-by":"publisher","first-page":"798367","DOI":"10.3389\/fcimb.2021.798367","volume":"11","author":"X Sun","year":"2022","unstructured":"Sun X, Yang Z, Nie Y, Hou B (2022) Microbial communities in the extraradicular and intraradicular infections associated with persistent apical periodontitis. Front Cell Infect Microbiol 11:798367. https:\/\/doi.org\/10.3389\/fcimb.2021.798367","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"10577_CR186","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3390\/jcm9030739","volume":"9","author":"M Dioguardi","year":"2020","unstructured":"Dioguardi M, Alovisi M, Crincoli V, Aiuto R, Malagnino G, Quarta C, Laneve E, Sovereto D, Lo Russo L, Troiano G, Muzio, Lo L (2020a) Prevalence of the genus propionibacterium in primary and persistent endodontic lesions: a systematic review. J Clin Med 9(3):739. https:\/\/doi.org\/10.3390\/jcm9030739","journal-title":"J Clin Med"},{"issue":"2","key":"10577_CR187","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3390\/jcm9020457","volume":"9","author":"M Dioguardi","year":"2020","unstructured":"Dioguardi M, Crincoli V, Laino L, Alovisi M, Sovereto D, Lo Muzio L, Troiano G (2020b) Prevalence of bacteria of genus actinomyces in persistent extraradicular lesions\u2014systematic review. J Clin Med 9(2):457. https:\/\/doi.org\/10.3390\/jcm9020457","journal-title":"J Clin Med"},{"key":"10577_CR188","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jfma.2016.08.010","volume":"116","author":"LW Lee","year":"2017","unstructured":"Lee LW, Lee YL, Hsiao SH, Lin HP (2017) Bacteria in the apical root canals of teeth with apical periodontitis. J Formos Med Assoc 116:448\u2013456. https:\/\/doi.org\/10.1016\/j.jfma.2016.08.010","journal-title":"J Formos Med Assoc"},{"key":"10577_CR189","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00082-12","author":"JF Siqueira","year":"2013","unstructured":"Siqueira JF, R\u00f4\u00e7as IN (2013) Microbiology and treatment of acute apical abscesses. Clin Microbiol Rev. https:\/\/doi.org\/10.1128\/CMR.00082-12","journal-title":"Clin Microbiol Rev"},{"key":"10577_CR190","doi-asserted-by":"publisher","first-page":"CD010136","DOI":"10.1002\/14651858.CD010136.pub3","volume":"5","author":"AL Cope","year":"2024","unstructured":"Cope AL, Francis N, Wood F, Thompson W, Chestnutt IG (2024) Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. Cochrane Database Syst Rev 5:CD010136. https:\/\/doi.org\/10.1002\/14651858.CD010136.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"10577_CR191","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.joen.2011.05.026","volume":"37","author":"IN R\u00f4as","year":"2011","unstructured":"R\u00f4as IN, Siqueira JF, Debelian GJ (2011) Analysis of symptomatic and asymptomatic primary root canal infections in adult Norwegian patients. J Endod 37:1206\u20131212. https:\/\/doi.org\/10.1016\/j.joen.2011.05.026","journal-title":"J Endod"},{"issue":"4","key":"10577_CR192","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1128\/CMR.17.4.840-862.2004","volume":"17","author":"JE Clarridge III","year":"2004","unstructured":"Clarridge JE III (2004) Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Clin Microbiol Rev 17(4):840\u2013862. https:\/\/doi.org\/10.1128\/CMR.17.4.840-862.2004","journal-title":"Clin Microbiol Rev"},{"issue":"9","key":"10577_CR193","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3390\/jcm8091339","volume":"8","author":"G Dahlen","year":"2019","unstructured":"Dahlen G, Basic A, Bylund J (2019) Importance of virulence factors for the persistence of oral bacteria in the inflamed gingival crevice and in the pathogenesis of periodontal disease. J Clin Med 8(9):1339. https:\/\/doi.org\/10.3390\/jcm8091339","journal-title":"J Clin Med"},{"key":"10577_CR194","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.5037\/jomr.2011.2401","volume":"2","author":"I Graunaite","year":"2011","unstructured":"Graunaite I, Lodiene G, Maciulskiene V (2011) Pathogenesis of apical periodontitis: a literature review. J. Oral Maxillofac. Res. 2:e1. https:\/\/doi.org\/10.5037\/jomr.2011.2401","journal-title":"J. Oral Maxillofac. Res."},{"issue":"2","key":"10577_CR195","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3390\/microorganisms9020445","volume":"9","author":"Z Heredia-Ponce","year":"2021","unstructured":"Heredia-Ponce Z, de Vicente A, Cazorla FM, Guti\u00e9rrez-Barranquero JA (2021) Beyond the wall: exopolysaccharides in the biofilm lifestyle of pathogenic and beneficial plant-associated pseudomonas. Microorganisms 9(2):445. https:\/\/doi.org\/10.3390\/microorganisms9020445","journal-title":"Microorganisms"},{"key":"10577_CR196","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1128\/microbiolspec.mb-0011-2014","volume":"3","author":"DH Limoli","year":"2015","unstructured":"Limoli DH, Jones CJ, Wozniak DJ (2015) Bacterial extracellular polysaccharides in biofilm formation and function. Microbial Spectr 3:223\u2013247. https:\/\/doi.org\/10.1128\/microbiolspec.mb-0011-2014","journal-title":"Microbial Spectr"},{"key":"10577_CR197","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1049\/mnl.2019.0747","volume":"15","author":"F Mohammadi","year":"2020","unstructured":"Mohammadi F, Abbaszadegan A, Gholami A (2020) Recent advances in nanodentistry: a special focus on endodontics. Micro Nano Lett 15:812\u2013816. https:\/\/doi.org\/10.1049\/mnl.2019.0747","journal-title":"Micro Nano Lett"},{"key":"10577_CR198","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4103\/1305-7456.175682","volume":"10","author":"S Tabassum","year":"2016","unstructured":"Tabassum S, Khan FR (2016) Failure of endodontic treatment: the usual suspects. Eur J Dent 10:144\u2013147. https:\/\/doi.org\/10.4103\/1305-7456.175682","journal-title":"Eur J Dent"},{"issue":"4","key":"10577_CR199","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4161\/viru.23987","volume":"4","author":"SS Grant","year":"2013","unstructured":"Grant SS, Hung DT (2013) Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence 4(4):273\u2013283. https:\/\/doi.org\/10.4161\/viru.23987","journal-title":"Virulence"},{"key":"10577_CR200","doi-asserted-by":"publisher","first-page":"171","DOI":"10.18773\/austprescr.2016.059","volume":"39","author":"E Bursle","year":"2016","unstructured":"Bursle E, Robson J (2016) Non-culture methods for detecting infection. Aust Prescr 39:171\u2013175. https:\/\/doi.org\/10.18773\/austprescr.2016.059","journal-title":"Aust Prescr"},{"key":"10577_CR201","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1111\/1541-4337.12618","volume":"19","author":"M Ferone","year":"2020","unstructured":"Ferone M, Gowen A, Fanning S, Scannell AGM (2020) Microbial detection and identification methods: bench top assays to omics approaches. Compr Rev Food Sci Food Saf 19:3106\u20133129. https:\/\/doi.org\/10.1111\/1541-4337.12618","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"10577_CR202","doi-asserted-by":"publisher","first-page":"22259","DOI":"10.1038\/srep22259","volume":"6","author":"K Nakamura","year":"2016","unstructured":"Nakamura K, Iizuka R, Nishi S, Yoshida T, Hatada Y, Takaki Y, Iguchi A, Yoon DH, Sekiguchi T, Shoji S, Funatsu T (2016) Culture-independent method for identification of microbial enzyme-encoding genes by activity-based single-cell sequencing using a water-in-oil microdroplet platform. Sci Rep 6:22259. https:\/\/doi.org\/10.1038\/srep22259","journal-title":"Sci Rep"},{"key":"10577_CR203","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","volume":"6","author":"M Balouiri","year":"2016","unstructured":"Balouiri M, Sadiki M, Ibnsouda SK (2016) Methods for in vitro evaluating antimicrobial activity: a review. J. Pharm. Anal. 6:71\u201379. https:\/\/doi.org\/10.1016\/j.jpha.2015.11.005","journal-title":"J. Pharm. Anal."},{"key":"10577_CR204","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.547458","author":"O Braissant","year":"2020","unstructured":"Braissant O, Astasov-Frauenhoffer M, Waltimo T, Bonkat G (2020) A review of methods to determine viability, vitality, and metabolic rates in microbiology. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2020.547458","journal-title":"Front Microbiol"},{"key":"10577_CR205","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1128\/CMR.00110-14","volume":"28","author":"JC Lagier","year":"2015","unstructured":"Lagier JC, Edouard S, Pagnier I, Mediannikov O, Drancourt M, Raoult D (2015) Current and past strategies for bacterial culture in clinical microbiology. Clin Microbiol Rev 28:208\u2013236. https:\/\/doi.org\/10.1128\/CMR.00110-14","journal-title":"Clin Microbiol Rev"},{"issue":"12","key":"10577_CR206","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.3390\/jcm10122707","volume":"10","author":"I Korona-Glowniak","year":"2021","unstructured":"Korona-Glowniak I, Piatek D, Fornal E, Lukowiak A, Gerasymchuk Y, Kedziora A, Bugla-P\u0142oskonska G, Grywalska E, Bachanek T, Malm A (2021) Patterns of oral microbiota in patients with apical periodontitis. J Clin Med 10(12):2707. https:\/\/doi.org\/10.3390\/jcm10122707","journal-title":"J Clin Med"},{"key":"10577_CR207","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s13205-012-0074-4","volume":"3","author":"F Adzitey","year":"2013","unstructured":"Adzitey F, Huda N, Ali GRR (2013) Molecular techniques for detecting and typing of bacteria, advantages and application to foodborne pathogens isolated from ducks. 3 Biotech 3:97\u2013107. https:\/\/doi.org\/10.1007\/s13205-012-0074-4","journal-title":"3 Biotech"},{"key":"10577_CR208","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1093\/cid\/cir692","volume":"53","author":"SK Rampini","year":"2011","unstructured":"Rampini SK, Bloemberg GV, Keller PM, B\u00fcchler AC, Dollenmaier G, Speck RF, B\u00f6ttger EC (2011) Broad-range 16S rRNA gene polymerase chain reaction for diagnosis of culture-negative bacterial infections. Clin Infect Dis 53:1245\u20131251. https:\/\/doi.org\/10.1093\/cid\/cir692","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10577_CR209","doi-asserted-by":"publisher","first-page":"32165","DOI":"10.1038\/srep32165","volume":"6","author":"R Rosselli","year":"2016","unstructured":"Rosselli R, Romoli O, Vitulo N, Vezzi A, Campanaro S, de Pascale F, Schiavon R, Tiarca M, Poletto F, Concheri G, Valle G (2016) Direct 16S rRNA-seq from bacterial communities: a PCR-independent approach to simultaneously assess microbial diversity and functional activity potential of each taxon. Sci Rep 6(1):32165. https:\/\/doi.org\/10.1038\/srep32165","journal-title":"Sci Rep"},{"key":"10577_CR210","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/tvst.9.13.2","volume":"9","author":"TF Somerville","year":"2020","unstructured":"Somerville TF, Corless CE, Sueke H, Neal T, Kaye SB (2020) 16S ribosomal RNA PCR versus conventional diagnostic culture in the investigation of suspected bacterial keratitis. Transl Vis Sci Technol 9:1\u20138. https:\/\/doi.org\/10.1167\/tvst.9.13.2","journal-title":"Transl Vis Sci Technol"},{"key":"10577_CR211","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ajodo.2019.01.026","volume":"157","author":"AN Gujar","year":"2020","unstructured":"Gujar AN, Al-Hazmi A, Raj AT, Patil S (2020) Microbial profile in different orthodontic appliances by checkerboard DNA-DNA hybridization: an in-vivo study. Am J Orthod Dentofac Orthop 157:49\u201358. https:\/\/doi.org\/10.1016\/j.ajodo.2019.01.026","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10577_CR212","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/aej.12159","volume":"42","author":"V Aw","year":"2016","unstructured":"Aw V (2016) Discuss the role of microorganisms in the aetiology and pathogenesis of periapical disease. Aust Endod J 42:53\u201359. https:\/\/doi.org\/10.1111\/aej.12159","journal-title":"Aust Endod J"},{"key":"10577_CR213","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-016-1976-2","volume":"16","author":"VB Rudkj\u00f8bing","year":"2016","unstructured":"Rudkj\u00f8bing VB, Thomsen TR, Xu Y, Melton-Kreft R, Ahmed A, Eickhardt S, Bjarnsholt T, Poulsen SS, Nielsen PH, Earl JP, Ehrlich GD (2016) Comparing culture and molecular methods for the identification of microorganisms involved in necrotizing soft tissue infections. BMC Infect Dis 16:1\u20133. https:\/\/doi.org\/10.1186\/s12879-016-1976-2","journal-title":"BMC Infect Dis"},{"issue":"12","key":"10577_CR214","doi-asserted-by":"publisher","first-page":"9121","DOI":"10.1002\/jcp.26956","volume":"233","author":"W Wei","year":"2018","unstructured":"Wei W, Ji S (2018) Cellular senescence: molecular mechanisms and pathogenicity. J Cell Physiol 233(12):9121\u20139135. https:\/\/doi.org\/10.1002\/jcp.26956","journal-title":"J Cell Physiol"},{"key":"10577_CR215","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.joen.2013.08.025","volume":"40","author":"M Brundin","year":"2014","unstructured":"Brundin M, Figdor D, Johansson A, Sj\u00f6gren U (2014) Preservation of bacterial DNA by human dentin. J Endod 40:241\u2013245. https:\/\/doi.org\/10.1016\/j.joen.2013.08.025","journal-title":"J Endod"},{"issue":"8","key":"10577_CR216","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.3390\/ijms18081748","volume":"18","author":"P Neelakantan","year":"2017","unstructured":"Neelakantan P, Romero M, Vera J, Daood U, Khan AU, Yan A, Cheung GSP (2017) Biofilms in endodontics\u2014current status and future directions. Int J Mol Sci 18(8):1748. https:\/\/doi.org\/10.3390\/ijms18081748","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10577_CR217","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.chom.2016.07.009","volume":"20","author":"FC Fang","year":"2016","unstructured":"Fang FC, Frawley ER, Tapscott T, V\u00e1zquez-Torres A (2016) Bacterial stress responses during host infection. Cell Host Microbe 20(2):133\u2013143. https:\/\/doi.org\/10.1016\/j.chom.2016.07.009","journal-title":"Cell Host Microbe"},{"key":"10577_CR218","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1007\/s00784-019-03075-9","volume":"24","author":"N Zargar","year":"2020","unstructured":"Zargar N, Ashraf H, Marashi SMA, Sabeti M, Aziz A (2020) Identification of microorganisms in irreversible pulpitis and primary endodontic infections with respect to clinical and radiographic findings. Clin Oral Investig 24:2099\u20132108. https:\/\/doi.org\/10.1007\/s00784-019-03075-9","journal-title":"Clin Oral Investig"},{"issue":"3","key":"10577_CR219","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.3390\/ijms22031480","volume":"22","author":"KM Galler","year":"2021","unstructured":"Galler KM, Weber M, Korkmaz Y, Widbiller M, Feuerer M (2021) Inflammatory response mechanisms of the dentine\u2013pulp complex and the periapical tissues. Int J Mol Sci 22(3):1480. https:\/\/doi.org\/10.3390\/ijms22031480","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10577_CR220","doi-asserted-by":"publisher","first-page":"038210","DOI":"10.1155\/2007\/38210","volume":"2007","author":"I Brekalo Pr\u0161o","year":"2007","unstructured":"Brekalo Pr\u0161o I, Kocjan W, \u0160imi\u0107 H, Brumini G, Pezelj-Ribari\u0107 S, Bor\u010di\u0107 J, Ferreri S, Mileti\u0107Karlovi\u0107 I (2007) Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions. Mediators Inflamm 2007(1):038210. https:\/\/doi.org\/10.1155\/2007\/38210","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10577_CR221","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41368-019-0068-8","volume":"12","author":"R Cheng","year":"2020","unstructured":"Cheng R, Wu Z, Li M, Shao M, Hu T (2020) Interleukin-1\u03b2 is a potential therapeutic target for periodontitis: a narrative review. Int J Oral Sci 12(1):2. https:\/\/doi.org\/10.1038\/s41368-019-0068-8","journal-title":"Int J Oral Sci"},{"issue":"03","key":"10577_CR222","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1055\/s-0040-1712718","volume":"14","author":"DE Ramadan","year":"2020","unstructured":"Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I (2020) Cytokines and chemokines in periodontitis. Eur J Dent 14(03):483\u2013495. https:\/\/doi.org\/10.1055\/s-0040-1712718","journal-title":"Eur J Dent"},{"issue":"11","key":"10577_CR223","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.3390\/ijms21113829","volume":"21","author":"SSB Qasim","year":"2020","unstructured":"Qasim SSB, Al-Otaibi D, Al-Jasser R, Gul SS, Zafar MS (2020) An evidence-based update on the molecular mechanisms underlying periodontal diseases. Int J Mol Sci 21(11):3829. https:\/\/doi.org\/10.3390\/ijms21113829","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10577_CR224","doi-asserted-by":"publisher","first-page":"e1009514","DOI":"10.1371\/journal.ppat.1009514","volume":"17","author":"EJ Stevens","year":"2021","unstructured":"Stevens EJ, Bates KA, King KC (2021) Host microbiota can facilitate pathogen infection. PLoS Pathog 17(5):e1009514. https:\/\/doi.org\/10.1371\/journal.ppat.1009514","journal-title":"PLoS Pathog"},{"issue":"3","key":"10577_CR225","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1086\/322044","volume":"184","author":"A Casadevall","year":"2001","unstructured":"Casadevall A, Pirofski LA (2001) Host-pathogen interactions: the attributes of virulence. J Infect Dis 184(3):337\u2013344. https:\/\/doi.org\/10.1086\/322044","journal-title":"J Infect Dis"},{"issue":"4","key":"10577_CR226","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.3390\/cells9041022","volume":"9","author":"B Lin","year":"2020","unstructured":"Lin B, Qing X, Liao J, Zhuo K (2020) Role of protein glycosylation in host-pathogen interaction. Cells 9(4):1022. https:\/\/doi.org\/10.3390\/cells9041022","journal-title":"Cells"},{"issue":"12","key":"10577_CR227","doi-asserted-by":"publisher","first-page":"e13261","DOI":"10.1111\/cmi.13261","volume":"22","author":"A Peignier","year":"2020","unstructured":"Peignier A, Parker D (2020) Trained immunity and host-pathogen interactions. Cell Microbiol 22(12):e13261. https:\/\/doi.org\/10.1111\/cmi.13261","journal-title":"Cell Microbiol"},{"issue":"1","key":"10577_CR228","doi-asserted-by":"publisher","first-page":"8209","DOI":"10.1038\/s41598-021-87464-9","volume":"11","author":"DE Gates","year":"2021","unstructured":"Gates DE, Staley M, Tardy L, Giraudeau M, Hill GE, McGraw KJ, Bonneaud C (2021) Levels of pathogen virulence and host resistance both shape the antibody response to an emerging bacterial disease. Sci Rep 11(1):8209. https:\/\/doi.org\/10.1038\/s41598-021-87464-9","journal-title":"Sci Rep"},{"key":"10577_CR229","doi-asserted-by":"publisher","first-page":"98","DOI":"10.9790\/0853-15080398102","volume":"15","author":"BD Deo","year":"2016","unstructured":"Deo BD, K S, Bhat KG (2016) Viruses in endodontic infections. IOSR J. Dent. Med. Sci. 15:98\u2013102. https:\/\/doi.org\/10.9790\/0853-15080398102","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"10577_CR230","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.2174\/1381612822666160216145107","volume":"22","author":"H Sasaki","year":"2016","unstructured":"Sasaki H, Hirai K, Martins M, C., Furusho, H., Battaglino, R., Hashimoto, K., (2016) Interrelationship between periapical lesion and systemic metabolic disorders. Curr Pharm Des 22:2204\u20132215. https:\/\/doi.org\/10.2174\/1381612822666160216145107","journal-title":"Curr Pharm Des"},{"issue":"2","key":"10577_CR231","doi-asserted-by":"publisher","first-page":"e356","DOI":"10.4317\/medoral.17452","volume":"17","author":"JJ Segura-Egea","year":"2011","unstructured":"Segura-Egea JJ, Castellanos-Cosano L, Machuca G, L\u00f3pez-L\u00f3pez J, Mart\u00edn-Gonz\u00e1lez J, Velasco-Ortega E, S\u00e1nchez-Dom\u00ednguez B, L\u00f3pez-Fr\u00edas FJ (2011) Diabetes mellitus, periapical inflammation and endodontic treatment outcome. Med Oral Patol Oral Cir Bucal 17(2):e356. https:\/\/doi.org\/10.4317\/medoral.17452","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10577_CR232","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1067\/moe.2002.126163","volume":"94","author":"JF Siqueira","year":"2002","unstructured":"Siqueira JF (2002) Endodontic infections: concepts, paradigms, and perspectives. Oral Surg. Oral Med. Oral Pathol Oral Radiol Endod 94:281\u2013293. https:\/\/doi.org\/10.1067\/moe.2002.126163","journal-title":"Oral Pathol Oral Radiol Endod"},{"key":"10577_CR233","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/iej.13647","volume":"55","author":"M Zehnder","year":"2022","unstructured":"Zehnder M, Belibasakis GN (2022) A critical analysis of research methods to study clinical molecular biomarkers in Endodontic research. Int Endod J 55:37\u201345. https:\/\/doi.org\/10.1111\/iej.13647","journal-title":"Int Endod J"},{"key":"10577_CR234","first-page":"106","volume":"11","author":"I Laxmi","year":"2021","unstructured":"Laxmi I, Kumar S, Ramesh S (2021) Comparison of inflammatory markers in saliva before and after endodontic treatment. Ann Med Health Sci Res 11:106\u2013112","journal-title":"Ann Med Health Sci Res"},{"key":"10577_CR235","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/jre.12181","volume":"50","author":"X Wu","year":"2015","unstructured":"Wu X, Offenbacher S, L\u00f3pez NJ, Chen D, Wang HY, Rogus J, Zhou J, Beck J, Jiang S, Bao X, Wilkins L, Doucette-Stamm L, Kornman K (2015) Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities. J Periodontal Res 50:52\u201361. https:\/\/doi.org\/10.1111\/jre.12181","journal-title":"J Periodontal Res"},{"key":"10577_CR236","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.joen.2015.01.037","volume":"41","author":"E Cotti","year":"2015","unstructured":"Cotti E, Zedda A, Deidda M, Piras A, Flore G, Ideo F, Madeddu C, Pau VM, Mercuro G (2015) Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women. J Endod 41:594\u2013600. https:\/\/doi.org\/10.1016\/j.joen.2015.01.037","journal-title":"J Endod"},{"issue":"11","key":"10577_CR237","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.joen.2019.07.017","volume":"45","author":"AC Georgiou","year":"2019","unstructured":"Georgiou AC, Crielaard W, Armenis I, de Vries R, van der Waal SV (2019) Apical periodontitis is associated with elevated concentrations of inflammatory mediators in peripheral blood: a systematic review and meta-analysis. J Endod 45(11):1279\u20131295. https:\/\/doi.org\/10.1016\/j.joen.2019.07.017","journal-title":"J Endod"},{"key":"10577_CR238","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/odi.12817","volume":"24","author":"U Harjunmaa","year":"2018","unstructured":"Harjunmaa U, Doyle R, J\u00e4rnstedt J, Kamiza S, Jorgensen JM, Stewart CP, Shaw L, Hallamaa L, Ashorn U, Klein N, Dewey KG, Maleta K, Ashorn P (2018) Periapical infection may affect birth outcomes via systemic inflammation. Oral Dis 24:847\u2013855. https:\/\/doi.org\/10.1111\/odi.12817","journal-title":"Oral Dis"},{"key":"10577_CR239","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1080\/00016357.2018.1522447","volume":"77","author":"DA Sirin","year":"2019","unstructured":"Sirin DA, Ozcelik F, Uzun C, Ersahan S, Yesilbas S (2019) Association between C-reactive protein, neutrophil to lymphocyte ratio and the burden of apical periodontitis: a case-control study. Acta Odontol Scand 77:142\u2013149. https:\/\/doi.org\/10.1080\/00016357.2018.1522447","journal-title":"Acta Odontol Scand"},{"key":"10577_CR240","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/iej.13444","volume":"54","author":"L Poornima","year":"2021","unstructured":"Poornima L, Ravishankar P, Abbott PV, Subbiya A, PradeepKumar AR (2021) Impact of root canal treatment on high-sensitivity C-reactive protein levels in systemically healthy adults with apical periodontitis \u2013 a preliminary prospective, longitudinal interventional study. Int Endod J 54:501\u2013508. https:\/\/doi.org\/10.1111\/iej.13444","journal-title":"Int Endod J"},{"issue":"9","key":"10577_CR241","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/iej.13786","volume":"55","author":"A Bakhsh","year":"2022","unstructured":"Bakhsh A, Moyes D, Proctor G, Mannocci F, Niazi SA (2022) The impact of apical periodontitis, non-surgical root canal retreatment and periapical surgery on serum inflammatory biomarkers. Int Endod J 55(9):923\u2013937. https:\/\/doi.org\/10.1111\/iej.13786","journal-title":"Int Endod J"},{"issue":"7","key":"10577_CR242","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3390\/medicina58070931","volume":"58","author":"SA Niazi","year":"2022","unstructured":"Niazi SA, Bakhsh A (2022) Association between endodontic infection, its treatment and systemic health: a narrative review. Medicina 58(7):931","journal-title":"Medicina"},{"key":"10577_CR243","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.11.008","author":"A Aminoshariae","year":"2017","unstructured":"Aminoshariae A, Kulild JC, Mickel A, Fouad AF (2017) Association between systemic diseases and endodontic outcome: a systematic review. J Endod. https:\/\/doi.org\/10.1016\/j.joen.2016.11.008","journal-title":"J Endod"},{"key":"10577_CR244","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1177\/0022034516660509","volume":"95","author":"JM Liljestrand","year":"2016","unstructured":"Liljestrand JM, M\u00e4ntyl\u00e4 P, Paju S, Buhlin K, Kopra KAE, Persson GR, Hernandez M, Nieminen MS, Sinisalo J, Tj\u00e4derhane L, Pussinen PJ (2016) Association of endodontic lesions with coronary artery disease. J Dent Res 95:1358\u20131365. https:\/\/doi.org\/10.1177\/0022034516660509","journal-title":"J Dent Res"},{"key":"10577_CR245","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/iej.12507","volume":"48","author":"JJ Segura-Egea","year":"2015","unstructured":"Segura-Egea JJ, Mart\u00edn-Gonz\u00e1lez J, Castellanos-Cosano L (2015) Endodontic medicine: connections between apical periodontitis and systemic diseases. Int Endod J 48:933\u2013951. https:\/\/doi.org\/10.1111\/iej.12507","journal-title":"Int Endod J"},{"key":"10577_CR246","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph17197261","volume":"17","author":"MJ Byon","year":"2020","unstructured":"Byon MJ, Kim SY, Kim JS, Kim HN, Kim JB (2020) Association of periodontitis with atherosclerotic cardiovascular diseases: a nationwide population-based retrospective matched cohort study. Int J Environ Res Public Health 17:1\u201310. https:\/\/doi.org\/10.3390\/ijerph17197261","journal-title":"Int J Environ Res Public Health"},{"key":"10577_CR247","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10266-006-0060-6","volume":"94","author":"J Kim","year":"2006","unstructured":"Kim J, Amar S (2006) Periodontal disease and systemic conditions: a bidirectional relationship. Odontology 94:10\u201321. https:\/\/doi.org\/10.1007\/s10266-006-0060-6","journal-title":"Odontology"},{"key":"10577_CR248","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1017\/erm.2013.8","volume":"15","author":"T Yucel-Lindberg","year":"2013","unstructured":"Yucel-Lindberg T, B\u00e5ge T (2013) Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med 15:e7. https:\/\/doi.org\/10.1017\/erm.2013.8","journal-title":"Expert Rev Mol Med"},{"key":"10577_CR249","doi-asserted-by":"publisher","first-page":"609614","DOI":"10.3389\/fphys.2020.609614","volume":"11","author":"O Paul","year":"2021","unstructured":"Paul O, Arora P, Mayer M, Chatterjee S (2021) Inflammation in periodontal disease: possible link to vascular disease. Front Physiol 11:609614. https:\/\/doi.org\/10.3389\/fphys.2020.609614","journal-title":"Front Physiol"},{"key":"10577_CR250","doi-asserted-by":"publisher","first-page":"e68","DOI":"10.1590\/1807-3107bor-2018.vol32.0068","volume":"32","author":"LTA Cintra","year":"2018","unstructured":"Cintra LTA, Estrela C, Azuma MM, Queiroz \u00cdODA, Kawai T, Gomes-Filho JE (2018) Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials. Braz Oral Res 32:e68. https:\/\/doi.org\/10.1590\/1807-3107bor-2018.vol32.0068","journal-title":"Braz Oral Res"},{"key":"10577_CR251","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/jech-2015-206745","volume":"71","author":"NGFM Beukers","year":"2017","unstructured":"Beukers NGFM, van der Heijden GJMG, van Wijk AJ, Loos BG (2017) Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands. J Epidemiol Community Health 71:37\u201342. https:\/\/doi.org\/10.1136\/jech-2015-206745","journal-title":"J Epidemiol Community Health"},{"key":"10577_CR252","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1111\/jcpe.12089","volume":"84","author":"MS Tonetti","year":"2013","unstructured":"Tonetti MS, Van Dyke TE (2013) Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol 84:S24\u2013S29. https:\/\/doi.org\/10.1111\/jcpe.12089","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10577_CR253","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/prd.12393","volume":"87","author":"L Sedghi","year":"2021","unstructured":"Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL (2021) The oral microbiome: role of key organisms and complex networks in oral health and disease. Periodontol 2000 87(1):107\u2013131. https:\/\/doi.org\/10.1111\/prd.12393","journal-title":"Periodontol 2000"},{"key":"10577_CR254","doi-asserted-by":"publisher","first-page":"241","DOI":"10.4103\/2278-9626.115996","volume":"2","author":"PVK Chakravarthy","year":"2013","unstructured":"Chakravarthy PVK (2013) Diabetes mellitus: an endodontic perspective. Eur J Gen Dent 2:241\u2013245. https:\/\/doi.org\/10.4103\/2278-9626.115996","journal-title":"Eur J Gen Dent"},{"key":"10577_CR255","doi-asserted-by":"publisher","first-page":"e3647","DOI":"10.7717\/peerj.3647","volume":"5","author":"CK Chen","year":"2017","unstructured":"Chen CK, Wu YT, Chang YC (2017) Periodontal inflammatory disease is associated with the risk of Parkinson\u2019s disease: a population-based retrospective matched-cohort study. PeerJ 5:e3647. https:\/\/doi.org\/10.7717\/peerj.3647","journal-title":"PeerJ"},{"key":"10577_CR256","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-020-05681-5","volume":"20","author":"J Gong","year":"2020","unstructured":"Gong J, Dong H, Xia QS, Huang ZY, Wang DK, Zhao Y, Liu WH, Tu SH, Zhang MM, Wang Q, Lu FE (2020) Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study. BMC Infect Dis 20:1\u20137. https:\/\/doi.org\/10.1186\/s12879-020-05681-5","journal-title":"BMC Infect Dis"},{"issue":"1","key":"10577_CR257","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/prd.12226","volume":"78","author":"A Sabharwal","year":"2018","unstructured":"Sabharwal A, Gomes-Filho IS, Stellrecht E, Scannapieco FA (2018) Role of periodontal therapy in management of common complex systemic diseases and conditions: an update. Periodontol 2000 78(1):212\u2013226","journal-title":"Periodontol 2000"},{"key":"10577_CR258","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12903-020-01356-4","volume":"21","author":"A Wojtkowska","year":"2021","unstructured":"Wojtkowska A, Zapolski T, Wysoki\u0144ska-Miszczuk J, Wysoki\u0144ski AP (2021) The inflammation link between periodontal disease and coronary atherosclerosis in patients with acute coronary syndromes: case\u2013control study. BMC Oral Health 21:1\u201317. https:\/\/doi.org\/10.1186\/s12903-020-01356-4","journal-title":"BMC Oral Health"},{"key":"10577_CR259","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm9123877","volume":"9","author":"L Manoharan","year":"2020","unstructured":"Manoharan L, Brundin M, Rakhimova O, de Paz LC, Vestman NR (2020) New insights into the microbial profiles of infected root canals in traumatized teeth. J Clin Med 9:1\u201314. https:\/\/doi.org\/10.3390\/jcm9123877","journal-title":"J Clin Med"},{"issue":"12","key":"10577_CR260","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/iej.12741","volume":"50","author":"JJ Segura-Egea","year":"2017","unstructured":"Segura-Egea JJ, Gould K, \u015een BH, Jonasson P, Cotti E, Mazzoni A, Sunay H, Tj\u00e4derhane L, Dummer PM (2017a) Antibiotics in endodontics: a review. Int Endod J 50(12):1169\u20131184. https:\/\/doi.org\/10.1111\/iej.12741","journal-title":"Int Endod J"},{"issue":"3","key":"10577_CR261","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.adaj.2015.11.002","volume":"147","author":"A Aminoshariae","year":"2016","unstructured":"Aminoshariae A, Kulild JC (2016) Evidence-based recommendations for antibiotic usage to treat endodontic infections and pain: A systematic review of randomized controlled trials. J Am Dent Assoc 147(3):186\u2013191. https:\/\/doi.org\/10.1016\/j.adaj.2015.11.002","journal-title":"J Am Dent Assoc"},{"issue":"8","key":"10577_CR262","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.3390\/ijms21082822","volume":"21","author":"SW Kim","year":"2020","unstructured":"Kim SW, Lee JS, Park SB, Lee AR, Jung JW, Chun JH, Lazarte JM, Kim J, Seo JS, Kim JH, Song JW (2020) The importance of porins and \u03b2-lactamase in outer membrane vesicles on the hydrolysis of \u03b2-lactam antibiotics. Int J Mol Sci 21(8):2822. https:\/\/doi.org\/10.3390\/ijms21082822","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10577_CR263","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1021\/acsinfecdis.8b00160","volume":"4","author":"PW Smith","year":"2018","unstructured":"Smith PW, Zuccotto F, Bates RH, Martinez-Martinez MS, Read KD, Peet C, Epemolu O (2018) Pharmacokinetics of \u03b2-lactam antibiotics: clues from the past to help discover long-acting oral drugs in the future. ACS Infect Dis 4(10):1439\u20131447. https:\/\/doi.org\/10.1021\/acsinfecdis.8b00160","journal-title":"ACS Infect Dis"},{"issue":"9","key":"10577_CR264","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1111\/iej.12913","volume":"51","author":"P Montero-Miralles","year":"2018","unstructured":"Montero-Miralles P, Mart\u00edn-Gonz\u00e1lez J, Alonso-Ezpeleta O, Jim\u00e9nez-S\u00e1nchez MC, Velasco-Ortega E, Segura-Egea JJ (2018) Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review. Int Endod J 51(9):981\u2013988. https:\/\/doi.org\/10.1111\/iej.12913","journal-title":"Int Endod J"},{"key":"10577_CR265","doi-asserted-by":"publisher","first-page":"448","DOI":"10.4067\/s0718-381x2020000300448","volume":"14","author":"N Seguel","year":"2020","unstructured":"Seguel N, Quezada-Aguiluz M, Gonz\u00e1lez-Rocha G, Bello-Toledo H, S\u00e1nchez-Sanhueza G (2020) Antibiotic resistance of Enterococcus faecalis from persistent endodontic infections. Int J Odontostomatol 14:448\u2013456. https:\/\/doi.org\/10.4067\/s0718-381x2020000300448","journal-title":"Int J Odontostomatol"},{"key":"10577_CR266","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.apjtm.2017.10.003","volume":"10","author":"E\u015e Y\u0131lmaz","year":"2017","unstructured":"Y\u0131lmaz E\u015e, Aslanta\u015f \u00d6 (2017) Antimicrobial resistance and underlying mechanisms in Staphylococcus aureus isolates. Asian Pac J Trop Med 10:1059\u20131064. https:\/\/doi.org\/10.1016\/j.apjtm.2017.10.003","journal-title":"Asian Pac J Trop Med"},{"key":"10577_CR267","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.11.028","author":"A Huttner","year":"2020","unstructured":"Huttner A, Bielicki J, Clements MN, Frimodt-M\u00f8ller N, Muller AE, Paccaud JP, Mouton JW (2020) Oral amoxicillin and amoxicillin\u2013clavulanic acid: properties, indications and usage. Clin Microbiol Infect. https:\/\/doi.org\/10.1016\/j.cmi.2019.11.028","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"10577_CR268","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ijantimicag.2016.08.018","volume":"48","author":"PM Lang","year":"2016","unstructured":"Lang PM, Jacinto RC, Dal Pizzol TS, Ferreira MBC, Montagner F (2016) Resistance profiles to antimicrobial agents in bacteria isolated from acute endodontic infections: systematic review and meta-analysis. Int J Antimicrob Agents 48(5):467\u2013474. https:\/\/doi.org\/10.1016\/j.ijantimicag.2016.08.018","journal-title":"Int J Antimicrob Agents"},{"issue":"1","key":"10577_CR269","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/iej.12781","volume":"51","author":"JJ Segura-Egea","year":"2018","unstructured":"Segura-Egea JJ, Gould K, Hakan \u015een B, Jonasson P, Cotti E, Mazzoni A, Sunay H, Tj\u00e4derhane L, Dummer PM (2018) European Society of Endodontology position statement: the use of antibiotics in endodontics. Int Endod J 51(1):20\u201325. https:\/\/doi.org\/10.1111\/iej.12781","journal-title":"Int Endod J"},{"issue":"1","key":"10577_CR270","doi-asserted-by":"publisher","first-page":"e000665","DOI":"10.1136\/bmjdrc-2019-000665","volume":"8","author":"JR G\u00f3mez-Sandoval","year":"2020","unstructured":"G\u00f3mez-Sandoval JR, Robles-Cervantes JA, Hern\u00e1ndez-Gonz\u00e1lez SO, Espinel-Bermudez MC, Mariaud-Schmidt R, Mart\u00ednez-Rodr\u00edguez V, Morgado-Castillo KC, Mercado-Sesma AR (2020) Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial. BMJ Open Diabetes Res Care 8(1):e000665. https:\/\/doi.org\/10.1136\/bmjdrc-2019-000665","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10577_CR271","doi-asserted-by":"publisher","unstructured":"Lim K, Widyarman AS (2018) The comparison of metronidazole, clindamycin, and amoxicillin againts Streptococcus sanguinis. J Indones Dent Assoc 1. https:\/\/doi.org\/10.32793\/jida.v1i1.293","DOI":"10.32793\/jida.v1i1.293"},{"key":"10577_CR272","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ijd.2012.03.002","volume":"4","author":"N Mittal","year":"2013","unstructured":"Mittal N, Jain J (2013) Antibiotics as an intracanal medicament in endodontics: a review. Indian J Dent 4:29\u201334. https:\/\/doi.org\/10.1016\/j.ijd.2012.03.002","journal-title":"Indian J Dent"},{"issue":"6","key":"10577_CR273","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/2042098614554919","volume":"5","author":"C Llor","year":"2014","unstructured":"Llor C, Bjerrum L (2014) Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf 5(6):229\u2013241. https:\/\/doi.org\/10.1177\/2042098614554919","journal-title":"Ther Adv Drug Saf"},{"issue":"4","key":"10577_CR274","doi-asserted-by":"publisher","first-page":"561","DOI":"10.24911\/ijmdc.51-1549060699","volume":"40","author":"N Mobarki","year":"2019","unstructured":"Mobarki N, Almerabi B, Hattan A (2019) Antibiotic resistance crisis. Int. J. Med. Dev. Ctries 40(4):561\u2013564. https:\/\/doi.org\/10.24911\/ijmdc.51-1549060699","journal-title":"Int. J. Med. Dev. Ctries"},{"key":"10577_CR275","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ejim.2022.01.029","volume":"99","author":"S Bassetti","year":"2022","unstructured":"Bassetti S, Tschudin-Sutter S, Egli A, Osthoff M (2022) Optimizing antibiotic therapies to reduce the risk of bacterial resistance. Eur J Intern Med 99:7\u201312. https:\/\/doi.org\/10.1016\/j.ejim.2022.01.029","journal-title":"Eur J Intern Med"},{"key":"10577_CR276","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1016\/j.jiph.2021.11.005","volume":"14","author":"HJ Kim","year":"2021","unstructured":"Kim HJ, Na SW, Alodaini HA, Al-Dosary MA, Nandhakumari P, Dyona L (2021) Prevalence of multidrug-resistant bacteria associated with polymicrobial infections. J Infect Public Health 14:1864\u20131869. https:\/\/doi.org\/10.1016\/j.jiph.2021.11.005","journal-title":"J Infect Public Health"},{"key":"10577_CR277","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.3389\/fmicb.2018.02928","volume":"9","author":"E Peterson","year":"2018","unstructured":"Peterson E, Kaur P (2018) Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front Microbiol 9:2928. https:\/\/doi.org\/10.3389\/fmicb.2018.02928","journal-title":"Front Microbiol"},{"key":"10577_CR278","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1128\/CMR.00086-12","volume":"26","author":"I Brook","year":"2013","unstructured":"Brook I, Wexler HM, Goldstein EJC (2013) Antianaerobic antimicrobials: spectrum and susceptibility testing. Clin Microbiol Rev 26:526\u2013546. https:\/\/doi.org\/10.1128\/CMR.00086-12","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"10577_CR279","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.sjbs.2017.01.004","volume":"24","author":"IA Rather","year":"2017","unstructured":"Rather IA, Kim BC, Bajpai VK, Park YH (2017) Self-medication and antibiotic resistance: crisis, current challenges, and prevention. Saudi J Biol Sci 24(4):808\u2013812. https:\/\/doi.org\/10.1016\/j.sjbs.2017.01.004","journal-title":"Saudi J Biol Sci"},{"issue":"12","key":"10577_CR280","doi-asserted-by":"publisher","first-page":"e0244585","DOI":"10.1371\/journal.pone.0244585","volume":"15","author":"SB Abraham","year":"2020","unstructured":"Abraham SB, Abdulla N, Himratul-Aznita WH, Awad M, Samaranayake LP, Ahmed HMA (2020) Antibiotic prescribing practices of dentists for endodontic infections; a cross-sectional study. PLoS ONE 15(12):e0244585. https:\/\/doi.org\/10.1371\/journal.pone.0244585","journal-title":"PLoS ONE"},{"issue":"5","key":"10577_CR281","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.mib.2013.06.013","volume":"16","author":"C De la Fuente-N\u00fa\u00f1ez","year":"2013","unstructured":"De la Fuente-N\u00fa\u00f1ez C, Reffuveille F, Fern\u00e1ndez L, Hancock RE (2013) Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. Curr Opin Microbiol 16(5):580\u2013589. https:\/\/doi.org\/10.1016\/j.mib.2013.06.013","journal-title":"Curr Opin Microbiol"},{"key":"10577_CR282","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.micpath.2017.11.039","volume":"114","author":"U Shabir","year":"2018","unstructured":"Shabir U, Ali S, Magray AR, Ganai BA, Firdous P, Hassan T, Nazir R (2018) Fish antimicrobial peptides (AMP\u2019s) as essential and promising molecular therapeutic agents: a review. Microbial Pathog 114:50\u201356. https:\/\/doi.org\/10.1016\/j.micpath.2017.11.039","journal-title":"Microbial Pathog"},{"issue":"4","key":"10577_CR283","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/AAC.02340-16","volume":"61","author":"CF Le","year":"2017","unstructured":"Le CF, Fang CM, Sekaran SD (2017) Intracellular targeting mechanisms by antimicrobial peptides. Antimicrob Agents Chemother 61(4):10\u20131128. https:\/\/doi.org\/10.1128\/AAC.02340-16","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10577_CR284","doi-asserted-by":"publisher","first-page":"250349","DOI":"10.1155\/2011\/250349","volume":"2011","author":"P Barbosa Pelegrini","year":"2011","unstructured":"Barbosa Pelegrini P, Del Sarto RP, Silva ON, Franco OL, Grossi-de-Sa MF (2011) Antibacterial peptides from plants: what they are and how they probably work. Biochem Res Int 2011(1):250349. https:\/\/doi.org\/10.1155\/2011\/250349","journal-title":"Biochem Res Int"},{"key":"10577_CR285","doi-asserted-by":"publisher","first-page":"610997","DOI":"10.3389\/fmedt.2020.610997","volume":"2","author":"AH Benfield","year":"2020","unstructured":"Benfield AH, Henriques ST (2020) Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms. Front Med Technol 2:610997. https:\/\/doi.org\/10.3389\/fmedt.2020.610997","journal-title":"Front Med Technol"},{"key":"10577_CR286","doi-asserted-by":"publisher","first-page":"107990","DOI":"10.1016\/j.pharmthera.2021.107990","volume":"232","author":"S Gera","year":"2022","unstructured":"Gera S, Kankuri E, Kogermann K (2022) Antimicrobial peptides\u2013unleashing their therapeutic potential using nanotechnology. Pharmacol Ther 232:107990. https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107990","journal-title":"Pharmacol Ther"},{"key":"10577_CR287","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1039\/b922985j","volume":"6","author":"S Taheri-Araghi","year":"2010","unstructured":"Taheri-Araghi S, Ha BY (2010) Cationic antimicrobial peptides: a physical basis for their selective membrane-disrupting activity. Soft Matter 6:1933\u20131940. https:\/\/doi.org\/10.1039\/b922985j","journal-title":"Soft Matter"},{"key":"10577_CR288","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.593215","author":"L Assoni","year":"2020","unstructured":"Assoni L, Milani B, Carvalho MR, Nepomuceno LN, Waz NT, Guerra MES, Converso TR, Darrieux M (2020) Resistance mechanisms to antimicrobial peptides in gram-positive bacteria. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2020.593215","journal-title":"Front Microbiol"},{"key":"10577_CR289","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1146\/annurev-micro-092412-155620","volume":"67","author":"S Brown","year":"2013","unstructured":"Brown S, Santa Maria JP, Walker S (2013) Wall teichoic acids of gram-positive bacteria. Annu Rev Microbiol 67:313\u2013336. https:\/\/doi.org\/10.1146\/annurev-micro-092412-155620","journal-title":"Annu Rev Microbiol"},{"issue":"4","key":"10577_CR290","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.jmii.2016.12.005","volume":"50","author":"PY Chung","year":"2017","unstructured":"Chung PY, Khanum R (2017) Antimicrobial peptides as potential anti-biofilm agents against multidrug-resistant bacteria. J Microbiol Immunol Infect 50(4):405\u2013410. https:\/\/doi.org\/10.1016\/j.jmii.2016.12.005","journal-title":"J Microbiol Immunol Infect"},{"issue":"4","key":"10577_CR291","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3390\/biom10040652","volume":"10","author":"A Di Somma","year":"2020","unstructured":"Di Somma A, Moretta A, Can\u00e8 C, Cirillo A, Duilio A (2020) Antimicrobial and antibiofilm peptides. Biomolecules 10(4):652. https:\/\/doi.org\/10.3390\/biom10040652","journal-title":"Biomolecules"},{"key":"10577_CR292","doi-asserted-by":"publisher","first-page":"76","DOI":"10.2174\/1568026615666150703121009","volume":"16","author":"M Scocchi","year":"2015","unstructured":"Scocchi M, Mardirossian M, Runti G, Benincasa M (2015) Non-membrane permeabilizing modes of action of antimicrobial peptides on bacteria. Curr Top Med Chem 16:76\u201388. https:\/\/doi.org\/10.2174\/1568026615666150703121009","journal-title":"Curr Top Med Chem"},{"key":"10577_CR293","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.bbamem.2015.02.021","volume":"1848","author":"T Anunthawan","year":"2015","unstructured":"Anunthawan T, De La Fuente-N\u00fa\u00f1ez C, Hancock REW, Klaynongsruang S (2015) Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria. Biochim Biophys Acta - Biomembr 1848:1352\u20131358. https:\/\/doi.org\/10.1016\/j.bbamem.2015.02.021","journal-title":"Biochim Biophys Acta - Biomembr"},{"issue":"02","key":"10577_CR294","doi-asserted-by":"publisher","first-page":"254","DOI":"10.4103\/1305-7456.130626","volume":"8","author":"SB Winfred","year":"2014","unstructured":"Winfred SB, Meiyazagan G, Panda JJ, Nagendrababu V, Deivanayagam K, Chauhan VS, Venkatraman G (2014) Antimicrobial activity of cationic peptides in endodontic procedures. Eur J Dent 8(02):254\u2013260. https:\/\/doi.org\/10.4103\/1305-7456.130626","journal-title":"Eur J Dent"},{"key":"10577_CR295","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40779-021-00343-2","volume":"8","author":"QY Zhang","year":"2021","unstructured":"Zhang QY, Yan ZB, Meng YM, Hong XY, Shao G, Ma JJ, Cheng XR, Liu J, Kang J, Fu CY (2021) Antimicrobial peptides: mechanism of action, activity and clinical potential. Mil Med Res 8:1\u201325. https:\/\/doi.org\/10.1186\/s40779-021-00343-2","journal-title":"Mil Med Res"},{"key":"10577_CR296","doi-asserted-by":"publisher","first-page":"24797","DOI":"10.1038\/srep24797","volume":"6","author":"S Devaraj","year":"2016","unstructured":"Devaraj S, Jagannathan N, Neelakantan P (2016) Antibiofilm efficacy of photoactivated curcumin, triple and double antibiotic paste, 2% chlorhexidine and calcium hydroxide against Enterococcus fecalis in vitro. Sci Rep 6:24797. https:\/\/doi.org\/10.1038\/srep24797","journal-title":"Sci Rep"},{"issue":"8","key":"10577_CR297","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/iej.12629","volume":"49","author":"KM Galler","year":"2016","unstructured":"Galler KM, Krastl G, Simon S, Van Gorp G, Meschi N, Vahedi B, Lambrechts P (2016) European Society of Endodontology position statement: revitalization procedures. Int Endod J 49(8):717\u2013723. https:\/\/doi.org\/10.1111\/iej.12629","journal-title":"Int Endod J"},{"key":"10577_CR298","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cden.2012.05.010","volume":"56","author":"TM Geisler","year":"2012","unstructured":"Geisler TM (2012) Clinical considerations for regenerative endodontic procedures. Dent Clin North Am 56:603\u2013626. https:\/\/doi.org\/10.1016\/j.cden.2012.05.010","journal-title":"Dent Clin North Am"},{"issue":"Suppl 3","key":"10577_CR299","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/iej.13731","volume":"55","author":"R Ordinola-Zapata","year":"2022","unstructured":"Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J (2022) Present status and future directions of intracanal medicaments. Int Endod J 55(Suppl 3):613\u2013636. https:\/\/doi.org\/10.1111\/iej.13731","journal-title":"Int Endod J"},{"key":"10577_CR300","doi-asserted-by":"publisher","first-page":"116139","DOI":"10.1016\/j.biopha.2024.116139","volume":"171","author":"VF Pedrinha","year":"2024","unstructured":"Pedrinha VF, Santos LM, Gon\u00e7alves CP, Garcia MT, Lameira OA, Queiroga CL, Marcucci MC, Shahbazi M-A, Sharma PK, Junqueira JC, Sipert CR, de Andrade FB (2024) Effects of natural antimicrobial compounds propolis and copaiba on periodontal ligament fibroblasts, molecular docking, and in vivo study in Galleria mellonella. Biomed Pharmacother 171:116139. https:\/\/doi.org\/10.1016\/j.biopha.2024.116139","journal-title":"Biomed Pharmacother"},{"key":"10577_CR301","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ijantimicag.2006.09.007","volume":"29","author":"E Urb\u00e1n","year":"2007","unstructured":"Urb\u00e1n E, Nagy E, P\u00e1l T, Sonnevend \u00c1, Conlon JM (2007) Activities of four frog skin-derived antimicrobial peptides (temporin-1DRa, temporin-1Va and the melittin-related peptides AR-23 and RV-23) against anaerobic bacteria. Int J Antimicrob Agents 29:317\u2013321. https:\/\/doi.org\/10.1016\/j.ijantimicag.2006.09.007","journal-title":"Int J Antimicrob Agents"},{"key":"10577_CR302","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1099\/13500872-145-4-965","volume":"145","author":"DA Devine","year":"1999","unstructured":"Devine DA, Marsh PD, Percival RS, Rangarajan M, Curtis MA (1999) Modulation of antibacterial peptide activity by products of Porphyromonas gingivalis and Prevotella spp. Microbiology 145:965\u2013971. https:\/\/doi.org\/10.1099\/13500872-145-4-965","journal-title":"Microbiology"},{"key":"10577_CR303","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.peptides.2012.01.006","volume":"33","author":"W Wang","year":"2012","unstructured":"Wang W, Tao R, Tong Z, Ding Y, Kuang R, Zhai S, Liu J, Ni L (2012) Effect of a novel antimicrobial peptide chrysophsin-1 on oral pathogens and Streptococcus mutans biofilms. Peptides 33:212\u2013219. https:\/\/doi.org\/10.1016\/j.peptides.2012.01.006","journal-title":"Peptides"},{"issue":"4","key":"10577_CR304","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.3390\/ijms23042066","volume":"23","author":"D Mancino","year":"2022","unstructured":"Mancino D, Kharouf N, Scavello F, Hell\u00e9 S, Salloum-Yared F, Mutschler A, Mathieu E, Lavalle P, Metz-Boutigue MH, Ha\u00efkel Y (2022) The catestatin-derived peptides are new actors to fight the development of oral candidosis. Int J Mol Sci 23(4):2066. https:\/\/doi.org\/10.3390\/ijms23042066","journal-title":"Int J Mol Sci"},{"key":"10577_CR305","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.2147\/IJN.S155245","volume":"13","author":"KL Aida","year":"2018","unstructured":"Aida KL, Kreling PF, Caiaffa KS, Calixto GMF, Chorilli M, Spolidorio DMP, Santos-Filho NA, Cilli EM, Duque C (2018) Antimicrobial peptide-loaded liquid crystalline precursor bioadhesive system for the prevention of dental caries. Int J Nanomedicine 13:3081\u20133091. https:\/\/doi.org\/10.2147\/IJN.S155245","journal-title":"Int J Nanomedicine"},{"key":"10577_CR306","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1159\/000442898","volume":"50","author":"H Tu","year":"2016","unstructured":"Tu H, Fan Y, Lv X, Han S, Zhou X, Zhang L (2016) Activity of synthetic antimicrobial peptide GH12 against oral streptococci. Caries Res 50:48\u201361. https:\/\/doi.org\/10.1159\/000442898","journal-title":"Caries Res"},{"key":"10577_CR307","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.joen.2011.12.026","volume":"38","author":"SH Lee","year":"2012","unstructured":"Lee SH, Baek DH (2012) Antibacterial and neutralizing effect of human \u03b2-defensins on enterococcus faecalis and enterococcus faecalis lipoteichoic acid. J Endod 38:351\u2013356. https:\/\/doi.org\/10.1016\/j.joen.2011.12.026","journal-title":"J Endod"},{"key":"10577_CR308","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ijantimicag.2008.05.022","volume":"33","author":"W Song","year":"2009","unstructured":"Song W, Shi Y, Xiao M, Lu H, Qu T, Li P, Wu G, Tian Y (2009) In vitro bactericidal activity of recombinant human \u03b2-defensin-3 against pathogenic bacterial strains in human tooth root canal. Int J Antimicrob Agents 33:237\u2013243. https:\/\/doi.org\/10.1016\/j.ijantimicag.2008.05.022","journal-title":"Int J Antimicrob Agents"},{"key":"10577_CR309","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/j.1600-0765.2006.00962.x","volume":"42","author":"S Ji","year":"2007","unstructured":"Ji S, Hyun J, Park E, Lee BL, Kim KK, Choi Y (2007) Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils. J Periodontal Res 42:410\u2013419. https:\/\/doi.org\/10.1111\/j.1600-0765.2006.00962.x","journal-title":"J Periodontal Res"},{"key":"10577_CR310","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1128\/IAI.05903-11","volume":"80","author":"G Rosen","year":"2012","unstructured":"Rosen G, Sela MN, Bachrach G (2012) The antibacterial activity of LL-37 against Treponema denticola is dentilisin protease independent and facilitated by the major outer sheath protein virulence factor. Infect Immun 80:1107\u20131114. https:\/\/doi.org\/10.1128\/IAI.05903-11","journal-title":"Infect Immun"},{"key":"10577_CR311","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bpj.2009.09.060","volume":"98","author":"S Thennarasu","year":"2010","unstructured":"Thennarasu S, Tan A, Penumatchu R, Shelburne CE, Heyl DL, Ramamoorthy A (2010) Antimicrobial and membrane disrupting activities of a peptide derived from the human cathelicidin antimicrobial peptide ll37. Biophys J 98:248\u2013257. https:\/\/doi.org\/10.1016\/j.bpj.2009.09.060","journal-title":"Biophys J"},{"key":"10577_CR312","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/yea.2925","volume":"29","author":"D Vukosavljevic","year":"2012","unstructured":"Vukosavljevic D, Custodio W, Del Bel Cury AA, Siqueira WL (2012) The effect of histatin 5, adsorbed on PMMA and hydroxyapatite, on Candida albicans colonization. Yeast 29:459\u2013466. https:\/\/doi.org\/10.1002\/yea.2925","journal-title":"Yeast"},{"key":"10577_CR313","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1902\/jop.2012.120017","volume":"84","author":"UK Gursoy","year":"2013","unstructured":"Gursoy UK, K\u00f6n\u00f6nen E, Luukkonen N, Uitto V-J (2013) Human neutrophil defensins and their effect on epithelial cells. J Periodontol 84:126\u2013133. https:\/\/doi.org\/10.1902\/jop.2012.120017","journal-title":"J Periodontol"},{"issue":"10","key":"10577_CR314","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.3390\/antibiotics10101220","volume":"10","author":"G Mergoni","year":"2021","unstructured":"Mergoni G, Manfredi M, Bertani P, Ciociola T, Conti S, Giovati L (2021) Activity of two antimicrobial peptides against enterococcus faecalis in a model of biofilm-mediated endodontic infection. Antibiotics 10(10):1220. https:\/\/doi.org\/10.3390\/antibiotics10101220","journal-title":"Antibiotics"},{"key":"10577_CR315","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1080\/08927014.2017.1370087","volume":"33","author":"KS Caiaffa","year":"2017","unstructured":"Caiaffa KS, Massunari L, Danelon M, Abuna GF, Bedran TBL, Santos-Filho NA, Spolidorio DMP, Vizoto NL, Cilli EM, Duque C (2017) KR-12-a5 is a non-cytotoxic agent with potent antimicrobial effects against oral pathogens. Biofouling 33:807\u2013818. https:\/\/doi.org\/10.1080\/08927014.2017.1370087","journal-title":"Biofouling"},{"key":"10577_CR316","doi-asserted-by":"publisher","first-page":"6656","DOI":"10.12659\/MSM.909093","volume":"24","author":"H Yuan","year":"2018","unstructured":"Yuan H, Zhang H, Hong L, Zhao H, Wang J, Li H, Che H, Zhang Z (2018) MicroRNA let-7c-5p suppressed lipopolysaccharide-induced dental pulp inflammation by inhibiting dentin matrix protein-1-mediated nuclear factor kappa b (NF-\u03bab) pathway in vitro and in vivo. Med Sci Monit 24:6656\u20136665. https:\/\/doi.org\/10.12659\/MSM.909093","journal-title":"Med Sci Monit"},{"key":"10577_CR317","doi-asserted-by":"publisher","first-page":"4125","DOI":"10.1128\/AAC.00208-07","volume":"51","author":"N Beckloff","year":"2007","unstructured":"Beckloff N, Laube D, Castro T, Furgang D, Park S, Perlin D, Clements D, Tang H, Scott RW, Tew GN, Diamond G (2007) Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens. Antimicrob Agents Chemother 51:4125\u20134132. https:\/\/doi.org\/10.1128\/AAC.00208-07","journal-title":"Antimicrob Agents Chemother"},{"key":"10577_CR318","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/j.1365-2591.2004.00846.x","volume":"37","author":"SR Turner","year":"2004","unstructured":"Turner SR, Love RM, Lyons KM (2004) An in-vitro investigation of the antibacterial effect of nisin in root canals and canal wall radicular dentine. Int Endod J 37:664\u2013671. https:\/\/doi.org\/10.1111\/j.1365-2591.2004.00846.x","journal-title":"Int Endod J"},{"key":"10577_CR319","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.peptides.2011.06.008","volume":"32","author":"R Tao","year":"2011","unstructured":"Tao R, Tong Z, Lin Y, Xue Y, Wang W, Kuang R, Wang P, Tian Y, Ni L (2011) Antimicrobial and antibiofilm activity of pleurocidin against cariogenic microorganisms. Peptides 32:1748\u20131754. https:\/\/doi.org\/10.1016\/j.peptides.2011.06.008","journal-title":"Peptides"},{"key":"10577_CR320","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1111\/odi.13799","volume":"28","author":"K Xiong","year":"2022","unstructured":"Xiong K, Chen X, Zhu H, Ji M, Zou L (2022) Anticaries activity of GERM CLEAN in Streptococcus mutans and Candida albicans dual-species biofilm. Oral Dis 28:829\u2013839. https:\/\/doi.org\/10.1111\/odi.13799","journal-title":"Oral Dis"},{"key":"10577_CR321","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1399-302X.2007.00389.x","volume":"23","author":"PL Weistroffer","year":"2008","unstructured":"Weistroffer PL, Joly S, Srikantha R, Tack BF, Brogden KA, Guthmiller JM (2008) SMAP29 congeners demonstrate activity against oral bacteria and reduced toxicity against oral keratinocytes. Oral Microbiol Immunol 23:89\u201395. https:\/\/doi.org\/10.1111\/j.1399-302X.2007.00389.x","journal-title":"Oral Microbiol Immunol"},{"key":"10577_CR322","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/cbf.3528","volume":"38","author":"J Hu","year":"2020","unstructured":"Hu J, Chen W, Qiu Z, Lv H (2020) Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel. Cell Biochem Funct 38:676\u2013682. https:\/\/doi.org\/10.1002\/cbf.3528","journal-title":"Cell Biochem Funct"},{"key":"10577_CR323","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/imm.12668","volume":"150","author":"R Singh","year":"2017","unstructured":"Singh R, Hui T, Matsui A, Allahem Z, Johnston CD, Ruiz-Torruella M, Rittling SR (2017) Modulation of infection-mediated migration of neutrophils and CXCR2 trafficking by osteopontin. Immunology 150:74\u201386. https:\/\/doi.org\/10.1111\/imm.12668","journal-title":"Immunology"},{"key":"10577_CR324","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1128\/IAI.00361-10","volume":"79","author":"CA Daep","year":"2011","unstructured":"Daep CA, Novak EA, Lamont RJ, Demuth DR (2011) Structural dissection and in vivo effectiveness of a peptide inhibitor of porphyromonas gingivalis adherence to streptococcus gordonii. Infect Immun 79:67\u201374. https:\/\/doi.org\/10.1128\/IAI.00361-10","journal-title":"Infect Immun"},{"key":"10577_CR325","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/jre.12393","volume":"52","author":"A Wilensky","year":"2017","unstructured":"Wilensky A, Potempa J, Houri-Haddad Y, Shapira L (2017) Vaccination with recombinant RgpA peptide protects against Porphyromonas gingivalis-induced bone loss. J Periodontal Res 52:285\u2013291. https:\/\/doi.org\/10.1111\/jre.12393","journal-title":"J Periodontal Res"},{"issue":"5","key":"10577_CR326","doi-asserted-by":"publisher","first-page":"e24122","DOI":"10.1002\/pep2.24122","volume":"111","author":"HB Koo","year":"2019","unstructured":"Koo HB, Seo J (2019) Antimicrobial peptides under clinical investigation. Pept Sci 111(5):e24122. https:\/\/doi.org\/10.1002\/pep2.24122","journal-title":"Pept Sci"},{"key":"10577_CR327","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/wrr.12211","volume":"22","author":"A Gr\u00f6nberg","year":"2014","unstructured":"Gr\u00f6nberg A, Mahlapuu M, St\u00e5hle M, Whately-Smith C, Rollman O (2014) Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trial. Wound Repair Regen 22:613\u2013621. https:\/\/doi.org\/10.1111\/wrr.12211","journal-title":"Wound Repair Regen"},{"issue":"6","key":"10577_CR328","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1080\/14712598.2017.1315402","volume":"17","author":"JM Sierra","year":"2017","unstructured":"Sierra JM, Fust\u00e9 E, Rabanal F, Vinuesa T, Vi\u00f1as M (2017) An overview of antimicrobial peptides and the latest advances in their development. Expert Opin Biol Ther 17(6):663\u2013676. https:\/\/doi.org\/10.1080\/14712598.2017.1315402","journal-title":"Expert Opin Biol Ther"},{"issue":"2","key":"10577_CR329","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3390\/v13020271","volume":"13","author":"A Bakovic","year":"2021","unstructured":"Bakovic A, Risner K, Bhalla N, Alem F, Chang TL, Weston WK, Harness JA, Narayanan A (2021) Brilacidin demonstrates inhibition of sars-cov-2 in cell culture. Viruses 13(2):271. https:\/\/doi.org\/10.3390\/v13020271","journal-title":"Viruses"},{"key":"10577_CR330","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1186\/s12903-024-04255-0","volume":"24","author":"S Shen","year":"2024","unstructured":"Shen S, Liu X, Huang J, Sun Y, Liu B, Song W, Meng L, Du M, Feng Q (2024) Efficacy of a mouthwash containing \u03b5-poly-L-lysine, funme peptides and domiphen in reducing halitosis and supragingival plaque: a randomized clinical trial. BMC Oral Health 24:525. https:\/\/doi.org\/10.1186\/s12903-024-04255-0","journal-title":"BMC Oral Health"},{"key":"10577_CR331","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.identj.2024.11.017","volume":"75","author":"X Liu","year":"2025","unstructured":"Liu X, Meng L, Song W, Zhi M, Wang P, Liu B, Du M, Feng Q (2025) Efficacy of toothpaste containing polylysine and funme peptide on oral microbiome and oral health. Int Dent J 75:1068\u20131080. https:\/\/doi.org\/10.1016\/j.identj.2024.11.017","journal-title":"Int Dent J"},{"key":"10577_CR332","doi-asserted-by":"publisher","first-page":"e943","DOI":"10.1002\/cre2.943","volume":"10","author":"JB Ryan","year":"2024","unstructured":"Ryan JB, Kirkwood BJ, Leung KP (2024) Combined phase 1\/2a initial clinical safety trials and proof-of-concept assessment of a novel antimicrobial peptide KSL-W anti-plaque chewing gum. Clin Exp Dent Res 10:e943. https:\/\/doi.org\/10.1002\/cre2.943","journal-title":"Clin Exp Dent Res"},{"key":"10577_CR333","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00784-024-05562-0","volume":"28","author":"SM Atteya","year":"2024","unstructured":"Atteya SM, Amer HA, Saleh SM, Safwat Y (2024) The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial. Clin Oral Investig 28:167. https:\/\/doi.org\/10.1007\/s00784-024-05562-0","journal-title":"Clin Oral Investig"},{"key":"10577_CR334","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1016\/j.jds.2024.07.011","volume":"19","author":"Y-F Wu","year":"2024","unstructured":"Wu Y-F, Han B-C, Lin W-Y, Wang S-Y, Linn TY, Hsu H-W, Wen C-C, Liu H-Y, Chen Y-H, Chang W-J (2024) Efficacy of antimicrobial peptide P113 oral health care products on the reduction of oral bacteria number and dental plaque formation in a randomized clinical assessment. J Dent Sci 19:2367\u20132376. https:\/\/doi.org\/10.1016\/j.jds.2024.07.011","journal-title":"J Dent Sci"},{"key":"10577_CR335","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1186\/s13104-015-1527-8","volume":"8","author":"S Takayama","year":"2015","unstructured":"Takayama S, Kato T, Imamura K, Kita D, Ota K, Suzuki E, Sugito H, Saitoh E, Taniguchi M, Saito A (2015) Effect of a mouthrinse containing rice peptide CL(14\u201325) on early dental plaque regrowth: a randomized crossover pilot study. BMC Res Notes 8:531. https:\/\/doi.org\/10.1186\/s13104-015-1527-8","journal-title":"BMC Res Notes"},{"key":"10577_CR336","doi-asserted-by":"publisher","first-page":"e0166997","DOI":"10.1371\/journal.pone.0166997","volume":"11","author":"T Zhang","year":"2016","unstructured":"Zhang T, Wang Z, Hancock REW, de la Fuente-N\u00fa\u00f1ez C, Haapasalo M (2016) Treatment of oral biofilms by a D-enantiomeric peptide. PLoS ONE 11:e0166997. https:\/\/doi.org\/10.1371\/journal.pone.0166997","journal-title":"PLoS ONE"},{"key":"10577_CR337","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.3390\/pharmaceutics14102081","volume":"14","author":"G Marianantoni","year":"2022","unstructured":"Marianantoni G, Meogrossi G, Tollapi E, Rencinai A, Brunetti J, Marruganti C, Gaeta C, Pini A, Bracci L, Ferrari M, Grandini S, Falciani C (2022) Antimicrobial peptides active in in vitro models of endodontic bacterial infections modulate inflammation in human cardiac fibroblasts. Pharmaceutics 14:2018. https:\/\/doi.org\/10.3390\/pharmaceutics14102081","journal-title":"Pharmaceutics"},{"issue":"2","key":"10577_CR338","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3390\/bioengineering10020214","volume":"10","author":"L Hardan","year":"2023","unstructured":"Hardan L, Chedid JC, Bourgi R, Cuevas-Su\u00e1rez CE, Lukomska-Szymanska M, Tosco V, Monjar\u00e1s-\u00c1vila AJ, Jabra M, Salloum-Yared F, Kharouf N, Mancino D (2023) Peptides in dentistry: a scoping review. Bioengineering 10(2):214. https:\/\/doi.org\/10.3390\/bioengineering10020214","journal-title":"Bioengineering"},{"key":"10577_CR339","doi-asserted-by":"publisher","first-page":"582779","DOI":"10.3389\/fmicb.2020.582779","volume":"11","author":"Y Huan","year":"2020","unstructured":"Huan Y, Kong Q, Mou H, Yi H (2020) Antimicrobial peptides: classification, design, application and research progress in multiple fields. Front Microbiol 11:582779. https:\/\/doi.org\/10.3389\/fmicb.2020.582779","journal-title":"Front Microbiol"},{"key":"10577_CR340","doi-asserted-by":"publisher","first-page":"D1087","DOI":"10.1093\/nar\/gkv1278","volume":"44","author":"G Wang","year":"2016","unstructured":"Wang G, Li X, Wang Z (2016) APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Res 44:D1087\u2013D1093. https:\/\/doi.org\/10.1093\/nar\/gkv1278","journal-title":"Nucleic Acids Res"},{"key":"10577_CR341","doi-asserted-by":"publisher","unstructured":"Haney EF, Mansour SC, Hancock REW (2017) Antimicrobial peptides: an introduction. In: Methods in Molecular Biology. pp 3\u201322. https:\/\/doi.org\/10.1007\/978-1-4939-6737-7_1","DOI":"10.1007\/978-1-4939-6737-7_1"},{"key":"10577_CR342","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.joen.2020.06.021","volume":"46","author":"FT Lundy","year":"2020","unstructured":"Lundy FT, Irwin CR, McLean DF, Linden GJ, El Karim IA (2020) Natural antimicrobials in the dental pulp. J Endod 46:S2\u2013S9. https:\/\/doi.org\/10.1016\/j.joen.2020.06.021","journal-title":"J Endod"},{"key":"10577_CR343","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.drup.2016.04.002","volume":"26","author":"DI Andersson","year":"2016","unstructured":"Andersson DI, Hughes D, Kubicek-Sutherland JZ (2016) Mechanisms and consequences of bacterial resistance to antimicrobial peptides. Drug Resist Updat 26:43\u201357. https:\/\/doi.org\/10.1016\/j.drup.2016.04.002","journal-title":"Drug Resist Updat"},{"key":"10577_CR344","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3934\/microbiol.2018.3.482","volume":"4","author":"WC Reygaert","year":"2018","unstructured":"Reygaert WC (2018) An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol 4:482\u2013501. https:\/\/doi.org\/10.3934\/microbiol.2018.3.482","journal-title":"AIMS Microbiol"},{"key":"10577_CR345","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3390\/antibiotics11101417","volume":"11","author":"J Talapko","year":"2022","unstructured":"Talapko J, Me\u0161trovi\u0107 T, Juzba\u0161i\u0107 M, Tomas M, Eri\u0107 S, Horvat Aleksijevi\u0107 L, Beki\u0107 S, Schwarz D, Mati\u0107 S, Neuberg M, \u0160krlec I (2022) Antimicrobial peptides-mechanisms of action, antimicrobial effects and clinical applications. Antibiot (Basel, Switzerland) 11:1417. https:\/\/doi.org\/10.3390\/antibiotics11101417","journal-title":"Antibiot (Basel, Switzerland)"},{"key":"10577_CR346","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.bbalip.2006.07.002","volume":"1761","author":"A Mulgrew-Nesbitt","year":"2006","unstructured":"Mulgrew-Nesbitt A, Diraviyam K, Wang J, Singh S, Murray P, Li Z, Rogers L, Mirkovic N, Murray D (2006) The role of electrostatics in protein\u2013membrane interactions. Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1761:812\u2013826. https:\/\/doi.org\/10.1016\/j.bbalip.2006.07.002","journal-title":"Biophys. Acta - Mol. Cell Biol. Lipids"},{"key":"10577_CR347","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev-micro-091213-112949","volume":"68","author":"MG Percy","year":"2014","unstructured":"Percy MG, Gr\u00fcndling A (2014) Lipoteichoic acid synthesis and function in gram-positive bacteria. Annu Rev Microbiol 68:81\u2013100. https:\/\/doi.org\/10.1146\/annurev-micro-091213-112949","journal-title":"Annu Rev Microbiol"},{"issue":"1695","key":"10577_CR348","doi-asserted-by":"publisher","first-page":"20150292","DOI":"10.1098\/rstb.2015.0292","volume":"371","author":"HS Joo","year":"2016","unstructured":"Joo HS, Fu CI, Otto M (2016) Bacterial strategies of resistance to antimicrobial peptides. Philos Trans R Soc B: Biol Sci 371(1695):20150292. https:\/\/doi.org\/10.1098\/rstb.2015.0292","journal-title":"Philos Trans R Soc B: Biol Sci"},{"key":"10577_CR349","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.3389\/fmicb.2017.01437","volume":"8","author":"R Kamar","year":"2017","unstructured":"Kamar R, R\u00e9jasse A, J\u00e9hanno I, Attieh Z, Courtin P, Chapot-Chartier MP, Nielsen-Leroux C, Lereclus D, El Chamy L, Kallassy M, Sanchis-Borja V (2017) DltX of bacillus thuringiensis is essential for D-Alanylation of teichoic acids and resistance to antimicrobial response in insects. Front Microbiol 8:1437. https:\/\/doi.org\/10.3389\/fmicb.2017.01437","journal-title":"Front Microbiol"},{"issue":"5","key":"10577_CR350","doi-asserted-by":"publisher","first-page":"e1004919","DOI":"10.1371\/journal.ppat.1004919","volume":"11","author":"F Carvalho","year":"2015","unstructured":"Carvalho F, Atilano ML, Pombinho R, Covas G, Gallo RL, Filipe SR, Sousa S, Cabanes D (2015) L-Rhamnosylation of Listeria monocytogenes wall teichoic acids promotes resistance to antimicrobial peptides by delaying interaction with the membrane. PLoS Pathog 11(5):e1004919. https:\/\/doi.org\/10.1371\/journal.ppat.1004919","journal-title":"PLoS Pathog"},{"key":"10577_CR351","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.anaerobe.2015.09.001","volume":"35","author":"S Wydau-Dematteis","year":"2015","unstructured":"Wydau-Dematteis S, Louis M, Zahr N, Lai-Kuen R, Saubam\u00e9a B, Butel MJ, Pons JL (2015) The functional dlt operon of Clostridium butyricum controls the d-alanylation of cell wall components and influences cell septation and vancomycin-induced lysis. Anaerobe 35:105\u2013114. https:\/\/doi.org\/10.1016\/j.anaerobe.2015.09.001","journal-title":"Anaerobe"},{"issue":"10","key":"10577_CR352","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3390\/genes12101527","volume":"12","author":"M Kawada-Matsuo","year":"2021","unstructured":"Kawada-Matsuo M, Le MNT, Komatsuzawa H (2021) Antibacterial peptides resistance in staphylococcus aureus: various mechanisms and the association with pathogenicity. Genes 12(10):1527. https:\/\/doi.org\/10.3390\/genes12101527","journal-title":"Genes"},{"issue":"1","key":"10577_CR353","doi-asserted-by":"publisher","first-page":"e02667","DOI":"10.1128\/mbio.02667-22","volume":"14","author":"A Guyet","year":"2023","unstructured":"Guyet A, Alofi A, Daniel RA (2023) Insights into the roles of lipoteichoic acids and MprF in Bacillus subtilis. MBio 14(1):e02667-e2722. https:\/\/doi.org\/10.1128\/mbio.02667-22","journal-title":"MBio"},{"key":"10577_CR354","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3210","author":"M Abdi","year":"2019","unstructured":"Abdi M, Mirkalantari S, Amirmozafari N (2019) Bacterial resistance to antimicrobial peptides. J Pept Sci. https:\/\/doi.org\/10.1002\/psc.3210","journal-title":"J Pept Sci"},{"key":"10577_CR355","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.bbamem.2015.03.007","volume":"1848","author":"R Kumariya","year":"2015","unstructured":"Kumariya R, Sood SK, Rajput YS, Saini N, Garsa AK (2015) Increased membrane surface positive charge and altered membrane fluidity leads to cationic antimicrobial peptide resistance in Enterococcus faecalis. Biochim Biophys Acta - Biomembr 1848:1367\u20131375. https:\/\/doi.org\/10.1016\/j.bbamem.2015.03.007","journal-title":"Biochim Biophys Acta - Biomembr"},{"issue":"1","key":"10577_CR356","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/antibiotics4010018","volume":"4","author":"VI Band","year":"2014","unstructured":"Band VI, Weiss DS (2014) Mechanisms of antimicrobial peptide resistance in gram-negative bacteria. Antibiotics 4(1):18\u201341. https:\/\/doi.org\/10.3390\/antibiotics4010018","journal-title":"Antibiotics"},{"key":"10577_CR357","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1021\/acs.biochem.1c00287","volume":"60","author":"T Shprung","year":"2021","unstructured":"Shprung T, Wani NA, Wilmes M, Mangoni ML, Bitler A, Shimoni E, Sahl HG, Shai Y (2021) Opposing effects of PhoPQ and PmrAB on the properties of Salmonella enterica serovar Typhimurium: implications on resistance to antimicrobial peptides. Biochemistry 60:2943\u20132955. https:\/\/doi.org\/10.1021\/acs.biochem.1c00287","journal-title":"Biochemistry"},{"issue":"7","key":"10577_CR358","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrmicro3047","volume":"11","author":"BD Needham","year":"2013","unstructured":"Needham BD, Trent MS (2013) Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis. Nat Rev Microbiol 11(7):467\u2013481. https:\/\/doi.org\/10.1038\/nrmicro3047","journal-title":"Nat Rev Microbiol"},{"key":"10577_CR359","doi-asserted-by":"publisher","first-page":"101780","DOI":"10.1016\/j.jcot.2022.101780","volume":"25","author":"T Hill","year":"2022","unstructured":"Hill T, Jain VK, Iyengar KP (2022) Antimicrobial peptides (AMP) in biofilm induced orthopaedic device-related infections. J Clin Orthop Trauma 25:101780. https:\/\/doi.org\/10.1016\/j.jcot.2022.101780","journal-title":"J Clin Orthop Trauma"},{"key":"10577_CR360","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.ebiom.2015.08.012","volume":"2","author":"JZ Kubicek-Sutherland","year":"2015","unstructured":"Kubicek-Sutherland JZ, Heithoff DM, Ersoy SC, Shimp WR, House JK, Marth JD, Smith JW, Mahan MJ (2015) Host-dependent induction of transient antibiotic resistance: a prelude to treatment failure. EBioMedicine 2:1169\u20131178. https:\/\/doi.org\/10.1016\/j.ebiom.2015.08.012","journal-title":"EBioMedicine"},{"issue":"10","key":"10577_CR361","doi-asserted-by":"publisher","first-page":"e0224440","DOI":"10.1371\/journal.pone.0224440","volume":"14","author":"MC Chambers","year":"2019","unstructured":"Chambers MC, Jacobson E, Khalil S, Lazzaro BP (2019) Consequences of chronic bacterial infection in Drosophila melanogaster. PLoS ONE 14(10):e0224440. https:\/\/doi.org\/10.1371\/journal.pone.0224440","journal-title":"PLoS ONE"},{"issue":"3","key":"10577_CR362","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.bbalip.2012.08.007","volume":"1831","author":"W Dowhan","year":"2013","unstructured":"Dowhan W (2013) A retrospective: Use of Escherichia coli as a vehicle to study phospholipid synthesis and function. Biochim Biophys Acta (BBA ) - Mol Cell Biol Lipids 1831(3):471\u2013494. https:\/\/doi.org\/10.1016\/j.bbalip.2012.08.007","journal-title":"Biochim Biophys Acta (BBA ) - Mol Cell Biol Lipids"},{"key":"10577_CR363","doi-asserted-by":"publisher","first-page":"11584","DOI":"10.1074\/jbc.M114.554444","volume":"289","author":"TH Zhang","year":"2014","unstructured":"Zhang TH, Muraih JK, Tishbi N, Herskowitz J, Victor RL, Silverman J, Uwumarenogie S, Taylor SD, Palmer M, Mintzer E (2014) Cardiolipin prevents membrane translocation and permeabilization by daptomycin. J Biol Chem 289:11584\u201311591. https:\/\/doi.org\/10.1074\/jbc.M114.554444","journal-title":"J Biol Chem"},{"key":"10577_CR364","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3139\/113.110632","volume":"56","author":"A Chojecka","year":"2019","unstructured":"Chojecka A, Tarka P, Kanecki K, Nitsch-Osuch A (2019) Evaluation of the Bactericidal activity of didecyl dimethyl ammonium chloride in 2-propanol against pseudomonas aeruginosa strains with adaptive resistance to this active substance according to European standards. Tenside, Surfactants, Deterg 56:287\u2013293. https:\/\/doi.org\/10.3139\/113.110632","journal-title":"Tenside, Surfactants, Deterg"},{"issue":"3","key":"10577_CR365","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ijantimicag.2010.11.019","volume":"37","author":"A Skiada","year":"2011","unstructured":"Skiada A, Markogiannakis A, Plachouras D, Daikos GL (2011) Adaptive resistance to cationic compounds in Pseudomonas aeruginosa. Int J Antimicrob Agents 37(3):187\u2013193. https:\/\/doi.org\/10.1016\/j.ijantimicag.2010.11.019","journal-title":"Int J Antimicrob Agents"},{"key":"10577_CR366","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/infdis\/jir396","volume":"204","author":"C Aubry","year":"2011","unstructured":"Aubry C, Goulard C, Nahori MA, Cayet N, Decalf J, Sachse M, Boneca IG, Cossart P, Dussurget O (2011) OatA, a peptidoglycan O-acetyltransferase involved in Listeria monocytogenes immune escape, is critical for virulence. J Infect Dis 204:731\u2013740. https:\/\/doi.org\/10.1093\/infdis\/jir396","journal-title":"J Infect Dis"},{"key":"10577_CR367","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1074\/jbc.M110.183236","volume":"286","author":"MH Laaberki","year":"2011","unstructured":"Laaberki MH, Pfeffer J, Clarke AJ, Dworkin J (2011) O-acetylation of peptidoglycan is required for proper cell separation and S-layer anchoring in Bacillus anthracis. J Biol Chem 286:5278\u20135288. https:\/\/doi.org\/10.1074\/jbc.M110.183236","journal-title":"J Biol Chem"},{"issue":"3","key":"10577_CR368","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/med.21869","volume":"42","author":"V Vimberg","year":"2022","unstructured":"Vimberg V, Buri\u00e1nkov\u00e1 K, Mazumdar A, Branny P, Novotn\u00e1 GB (2022) Role of membrane proteins in bacterial resistance to antimicrobial peptides. Med Res Rev 42(3):1023\u20131036. https:\/\/doi.org\/10.1002\/med.21869","journal-title":"Med Res Rev"},{"key":"10577_CR369","doi-asserted-by":"publisher","first-page":"18692","DOI":"10.1074\/jbc.M111.226886","volume":"286","author":"J Andr\u00e4","year":"2011","unstructured":"Andr\u00e4 J, Goldmann T, Ernst CM, Peschel A, Gutsmann T (2011) Multiple peptide resistance factor (MprF)-mediated resistance of Staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl- phosphatidylglycerol. J Biol Chem 286:18692\u201318700. https:\/\/doi.org\/10.1074\/jbc.M111.226886","journal-title":"J Biol Chem"},{"key":"10577_CR370","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1016\/j.bbamem.2014.04.018","volume":"1838","author":"E Cox","year":"2014","unstructured":"Cox E, Michalak A, Pagentine S, Seaton P, Pokorny A (2014) Lysylated phospholipids stabilize models of bacterial lipid bilayers and protect against antimicrobial peptides. Biochim Biophys Acta - Biomembr 1838:2198\u20132204. https:\/\/doi.org\/10.1016\/j.bbamem.2014.04.018","journal-title":"Biochim Biophys Acta - Biomembr"},{"key":"10577_CR371","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1128\/AAC.02182-12","volume":"57","author":"NN Mishra","year":"2013","unstructured":"Mishra NN, Bayer AS (2013) Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant staphylococcus aureus. Antimicrob Agents Chemother 57:1082\u20131085. https:\/\/doi.org\/10.1128\/AAC.02182-12","journal-title":"Antimicrob Agents Chemother"},{"key":"10577_CR372","doi-asserted-by":"publisher","first-page":"19066","DOI":"10.1074\/jbc.RA119.009510","volume":"294","author":"L Grifoll-Romero","year":"2019","unstructured":"Grifoll-Romero L, Sainz-Polo MA, Albesa-Jov\u00e9 D, Guerin ME, Biarn\u00e9s X, Planas A (2019) Structure-function relationships underlying the dual N-acetylmuramic and N-acetylglucosamine specificities of the bacterial peptidoglycan deacetylase PdaC. J Biol Chem 294:19066\u201319080. https:\/\/doi.org\/10.1074\/jbc.RA119.009510","journal-title":"J Biol Chem"},{"issue":"4","key":"10577_CR373","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3390\/pathogens9040290","volume":"9","author":"D Meireles","year":"2020","unstructured":"Meireles D, Pombinho R, Carvalho F, Sousa S, Cabanes D (2020) Listeria monocytogenes wall teichoic acid glycosylation promotes surface anchoring of virulence factors, resistance to antimicrobial peptides, and decreased susceptibility to antibiotics. Pathogens 9(4):290. https:\/\/doi.org\/10.3390\/pathogens9040290","journal-title":"Pathogens"},{"key":"10577_CR374","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12551-021-00784-y","volume":"13","author":"P Cardoso","year":"2021","unstructured":"Cardoso P, Glossop H, Meikle TG, Aburto-Medina A, Conn CE, Sarojini V, Valery C (2021) Molecular engineering of antimicrobial peptides: microbial targets, peptide motifs and translation opportunities. Biophys Rev 13:35\u201369. https:\/\/doi.org\/10.1007\/s12551-021-00784-y","journal-title":"Biophys Rev"},{"key":"10577_CR375","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1128\/microbiolspec.vmbf-0006-2015","volume":"4","author":"JN Cole","year":"2016","unstructured":"Cole JN, Nizet V (2016) Bacterial evasion of host antimicrobial peptide defenses. Microbiol. Spectr. 4:413\u2013443. https:\/\/doi.org\/10.1128\/microbiolspec.vmbf-0006-2015","journal-title":"Microbiol. Spectr."},{"issue":"6","key":"10577_CR376","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/antibiotics10060650","volume":"10","author":"KE Ridyard","year":"2021","unstructured":"Ridyard KE, Overhage J (2021) The potential of human peptide ll-37 as an antimicrobial and anti-biofilm agent. Antibiotics 10(6):650. https:\/\/doi.org\/10.3390\/antibiotics10060650","journal-title":"Antibiotics"},{"key":"10577_CR377","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.bbamem.2015.11.003","volume":"1858","author":"D Xhindoli","year":"2016","unstructured":"Xhindoli D, Pacor S, Benincasa M, Scocchi M, Gennaro R, Tossi A (2016) The human cathelicidin LL-37 - a pore-forming antibacterial peptide and host-cell modulator. Biochim Biophys Acta - Biomembr 1858:546\u2013566. https:\/\/doi.org\/10.1016\/j.bbamem.2015.11.003","journal-title":"Biochim Biophys Acta - Biomembr"},{"issue":"13","key":"10577_CR378","doi-asserted-by":"publisher","first-page":"7820","DOI":"10.1039\/d0cs00729c","volume":"50","author":"BH Gan","year":"2021","unstructured":"Gan BH, Gaynord J, Rowe SM, Deingruber T, Spring DR (2021) The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions. Chem Soc Rev 50(13):7820\u20137880. https:\/\/doi.org\/10.1039\/d0cs00729c","journal-title":"Chem Soc Rev"},{"key":"10577_CR379","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.fsi.2017.11.003","volume":"72","author":"B Houyvet","year":"2018","unstructured":"Houyvet B, Bouchon-Navaro Y, Bouchon C, Goux D, Bernay B, Corre E, Zatylny-Gaudin C (2018) Identification of a moronecidin-like antimicrobial peptide in the venomous fish Pterois volitans: functional and structural study of pteroicidin-\u03b1. Fish Shellfish Immunol 72:318\u2013324. https:\/\/doi.org\/10.1016\/j.fsi.2017.11.003","journal-title":"Fish Shellfish Immunol"},{"issue":"8","key":"10577_CR380","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.3390\/ph6081055","volume":"6","author":"W Aoki","year":"2013","unstructured":"Aoki W, Ueda M (2013) Characterization of antimicrobial peptides toward the development of novel antibiotics. Pharmaceuticals 6(8):1055\u20131081. https:\/\/doi.org\/10.3390\/ph6081055","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10577_CR381","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/IAI.00755-17","volume":"86","author":"N Dzvova","year":"2018","unstructured":"Dzvova N, Colmer-Hamood JA, Griswold JA, Hamood AN (2018) Heparinase is essential for Pseudomonas aeruginosa virulence during thermal injury and infection. Infect Immun 86(1):10\u20131128. https:\/\/doi.org\/10.1128\/IAI.00755-17","journal-title":"Infect Immun"},{"issue":"2","key":"10577_CR382","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4103\/ijmr.IJMR_2079_17","volume":"149","author":"A Sharma","year":"2019","unstructured":"Sharma A, Gupta VK, Pathania R (2019) Efflux pump inhibitors for bacterial pathogens: from bench to bedside. Indian J Med Res 149(2):129\u2013145. https:\/\/doi.org\/10.4103\/ijmr.IJMR_2079_17","journal-title":"Indian J Med Res"},{"key":"10577_CR383","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1128\/JB.185.1.51-59.2003","volume":"185","author":"R Ohki","year":"2003","unstructured":"Ohki R, Tateno K, Okada Y, Okajima H, Asai K, Sadaie Y, Murata M, Aiso T (2003) A bacitracin-resistant Bacillus subtilis gene encodes a homologue of the membrane-spanning subunit of the Bacillus licheniformis ABC transporter. J Bacteriol 185:51\u201359. https:\/\/doi.org\/10.1128\/JB.185.1.51-59.2003","journal-title":"J Bacteriol"},{"key":"10577_CR384","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1128\/JB.00419-13","volume":"195","author":"F Kallenberg","year":"2013","unstructured":"Kallenberg F, Dintner S, Schmitz R, Gebhard S (2013) Identification of regions important for resistance and signalling within the antimicrobial peptide transporter BceAB of Bacillus subtilis. J Bacteriol 195:3287\u20133297. https:\/\/doi.org\/10.1128\/JB.00419-13","journal-title":"J Bacteriol"},{"key":"10577_CR385","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1111\/iwj.12790","volume":"14","author":"S Lindsay","year":"2017","unstructured":"Lindsay S, Oates A, Bourdillon K (2017) The detrimental impact of extracellular bacterial proteases on wound healing. Int Wound J 14:1237\u20131247. https:\/\/doi.org\/10.1111\/iwj.12790","journal-title":"Int Wound J"},{"key":"10577_CR386","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/fmicb.2013.00353","volume":"4","author":"F Guilhelmelli","year":"2013","unstructured":"Guilhelmelli F, Vilela N, Albuquerque P, Derengowski LDS, Silva-Pereira I, Kyaw CM (2013) Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance. Front Microbiol 4:353. https:\/\/doi.org\/10.3389\/fmicb.2013.00353","journal-title":"Front Microbiol"},{"key":"10577_CR387","doi-asserted-by":"publisher","first-page":"22926","DOI":"10.1074\/jbc.M114.579672","volume":"289","author":"A Sol","year":"2014","unstructured":"Sol A, Skvirsky Y, Nashef R, Zelentsova K, Burstyn-Cohen T, Blotnick E, Muhlrad A, Bachrach G (2014) Actin enables the antimicrobial action of LL-37 peptide in the presence of microbial proteases. J Biol Chem 289:22926\u201322941. https:\/\/doi.org\/10.1074\/jbc.M114.579672","journal-title":"J Biol Chem"},{"key":"10577_CR388","doi-asserted-by":"publisher","first-page":"691532","DOI":"10.3389\/fchem.2021.691532","volume":"9","author":"T Sarkar","year":"2021","unstructured":"Sarkar T, Chetia M, Chatterjee S (2021) Antimicrobial peptides and proteins: from nature\u2019s reservoir to the laboratory and beyond. Front Chem 9:691532. https:\/\/doi.org\/10.3389\/fchem.2021.691532","journal-title":"Front Chem"},{"issue":"3","key":"10577_CR389","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1177\/0022034516679973","volume":"96","author":"B Bechinger","year":"2017","unstructured":"Bechinger B, Gorr SU (2017) Antimicrobial Peptides: mechanisms of action and resistance. J Dent Res 96(3):254\u2013260. https:\/\/doi.org\/10.1177\/0022034516679973","journal-title":"J Dent Res"},{"key":"10577_CR390","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1128\/IAI.05674-11","volume":"80","author":"JL Thomassin","year":"2012","unstructured":"Thomassin JL, Brannon JR, Gibbs BF, Gruenheid S, Le Moual H (2012) OmpT outer membrane proteases of enterohemorrhagic and enteropathogenic Escherichia coli contribute differently to the degradation of human LL-37. Infect Immun 80:483\u2013492. https:\/\/doi.org\/10.1128\/IAI.05674-11","journal-title":"Infect Immun"},{"key":"10577_CR391","doi-asserted-by":"publisher","first-page":"5682","DOI":"10.1128\/AEM.01797-13","volume":"79","author":"TM Bergholz","year":"2013","unstructured":"Bergholz TM, Tang S, Wiedmann M, Boor KJ (2013) Nisin resistance of listeria monocytogenes is increased by exposure to salt stress and is mediated via liar. Appl Environ Microbiol 79:5682\u20135688. https:\/\/doi.org\/10.1128\/AEM.01797-13","journal-title":"Appl Environ Microbiol"},{"key":"10577_CR392","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/fsn3.1285","volume":"8","author":"X Wu","year":"2020","unstructured":"Wu X, Ju X, Du L, Wang L, He R, Chen Z (2020) The Man-PTS subunit IIC is responsible for the sensitivity of Listeria monocytogenes to durancin GL. Food Sci Nutr 8:150\u2013161. https:\/\/doi.org\/10.1002\/fsn3.1285","journal-title":"Food Sci Nutr"},{"issue":"10","key":"10577_CR393","doi-asserted-by":"publisher","first-page":"e0164973","DOI":"10.1371\/journal.pone.0164973","volume":"11","author":"W Zhou","year":"2016","unstructured":"Zhou W, Wang G, Wang C, Ren F, Hao Y (2016) Both IIC and IID components of mannose phosphotransferase system are involved in the specific recognition between immunity protein PedB and bacteriocin-receptor complex. PLoS ONE 11(10):e0164973. https:\/\/doi.org\/10.1371\/journal.pone.0164973","journal-title":"PLoS ONE"},{"key":"10577_CR394","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1089\/wound.2016.0713","volume":"6","author":"GL Griffith","year":"2017","unstructured":"Griffith GL, Kasus-Jacobi A, Pereira HA (2017) Bioactive antimicrobial peptides as therapeutics for corneal wounds and infections. Adv Wound Care 6:175\u2013190. https:\/\/doi.org\/10.1089\/wound.2016.0713","journal-title":"Adv Wound Care"},{"issue":"8","key":"10577_CR395","doi-asserted-by":"publisher","first-page":"669","DOI":"10.2217\/imt-2020-0312","volume":"13","author":"K Kardani","year":"2021","unstructured":"Kardani K, Bolhassani A (2021) Antimicrobial\/anticancer peptides: bioactive molecules and therapeutic agents. Immunotherapy 13(8):669\u2013684. https:\/\/doi.org\/10.2217\/imt-2020-0312","journal-title":"Immunotherapy"},{"key":"10577_CR396","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fmicb.2020.00103","volume":"11","author":"B El Shazely","year":"2020","unstructured":"El Shazely B, Yu G, Johnston PR, Rolff J (2020) Resistance evolution against antimicrobial peptides in Staphylococcus aureus alters pharmacodynamics beyond the MIC. Front Microbiol 11:103. https:\/\/doi.org\/10.3389\/fmicb.2020.00103","journal-title":"Front Microbiol"},{"key":"10577_CR397","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1128\/AAC.05551-11","volume":"56","author":"G Sakoulas","year":"2012","unstructured":"Sakoulas G, Bayer AS, Pogliano J, Tsuji BT, Yang SJ, Mishra NN, Nizet V, Yeaman MR, Moise PA (2012) Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 56:838\u2013844. https:\/\/doi.org\/10.1128\/AAC.05551-11","journal-title":"Antimicrob Agents Chemother"},{"key":"10577_CR398","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fcimb.2019.00128","volume":"9","author":"MS Zharkova","year":"2019","unstructured":"Zharkova MS, Orlov DS, Golubeva OY, Chakchir OB, Eliseev IE, Grinchuk TM, Shamova OV (2019) Application of antimicrobial peptides of the innate immune system in combination with conventional antibiotics\u2014a novel way to combat antibiotic resistance? Front Cell Infect Microbiol 9:128. https:\/\/doi.org\/10.3389\/fcimb.2019.00128","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10577_CR399","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1002\/med.21879","volume":"42","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Hao W, Wang X, Ouyang J, Deng X, Yu H, Wang Y (2022) Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug-resistant infections. Med Res Rev 42(4):1377\u20131422. https:\/\/doi.org\/10.1002\/med.21879","journal-title":"Med Res Rev"},{"key":"10577_CR400","doi-asserted-by":"publisher","first-page":"940","DOI":"10.2174\/0929866522666150728115439","volume":"22","author":"J Amani","year":"2015","unstructured":"Amani J, Barjini K, Moghaddam M, Asadi A (2015) In vitro synergistic effect of the CM11 antimicrobial peptide in combination with common antibiotics against clinical isolates of six species of multidrug-resistant pathogenic bacteria. Protein Pept Lett 22:940\u2013951. https:\/\/doi.org\/10.2174\/0929866522666150728115439","journal-title":"Protein Pept Lett"},{"key":"10577_CR401","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/fbe2.12057","volume":"2","author":"A Alzaydi","year":"2023","unstructured":"Alzaydi A, Barbhuiya RI, Routray W, Elsayed A, Singh A (2023) Bioactive peptides: synthesis, applications, and associated challenges. Food Bioeng. 2:273\u2013290. https:\/\/doi.org\/10.1002\/fbe2.12057","journal-title":"Food Bioeng."},{"issue":"18","key":"10577_CR402","doi-asserted-by":"publisher","first-page":"14056","DOI":"10.3390\/ijms241814056","volume":"24","author":"M Leveque","year":"2023","unstructured":"Leveque M, Bekhouche M, Farges JC, Aussel A, Sy K, Richert R, Ducret M (2023) Bioactive endodontic hydrogels: from parameters to personalized medicine. Int J Mol Sci 24(18):14056. https:\/\/doi.org\/10.3390\/ijms241814056","journal-title":"Int J Mol Sci"},{"key":"10577_CR403","doi-asserted-by":"publisher","first-page":"655495","DOI":"10.3389\/fmats.2021.655495","volume":"8","author":"M Berm\u00fadez","year":"2021","unstructured":"Berm\u00fadez M, Hoz L, Montoya G, Nidome M, P\u00e9rez-Soria A, Romo E, Soto-Barreras U, Garnica-Palazuelos J, Aguilar-Medina M, Ramos-Pay\u00e1n R (2021) Bioactive synthetic peptides for oral tissues regeneration. Front Mater 8:655495","journal-title":"Front Mater"},{"key":"10577_CR404","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/0972-0707.148861","volume":"18","author":"R Bansal","year":"2015","unstructured":"Bansal R, Jain A, Mittal S (2015) Current overview on challenges in regenerative endodontics. J Conserv Dent 18:1\u20136. https:\/\/doi.org\/10.4103\/0972-0707.148861","journal-title":"J Conserv Dent"},{"issue":"4","key":"10577_CR405","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3390\/biomimetics7040229","volume":"7","author":"N Kumar","year":"2022","unstructured":"Kumar N, Maher N, Amin F, Ghabbani H, Zafar MS, Rodr\u00edguez-Lozano FJ, O\u00f1ate-S\u00e1nchez RE (2022) Biomimetic approaches in clinical endodontics. Biomimetics 7(4):229. https:\/\/doi.org\/10.3390\/biomimetics7040229","journal-title":"Biomimetics"},{"key":"10577_CR406","doi-asserted-by":"publisher","first-page":"120","DOI":"10.18502\/ijm.v11i2.1073","volume":"11","author":"N Zargar","year":"2019","unstructured":"Zargar N, Marashi MA, Ashraf H, Hakopian R, Beigi P (2019) Identification of microorganisms in persistent\/secondary endodontic infections with respect to clinical and radiographic findings: bacterial culture and molecular detection. Iran. J. Microbiol. 11:120\u2013128. https:\/\/doi.org\/10.18502\/ijm.v11i2.1073","journal-title":"Iran. J. Microbiol."}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10577-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10577-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10577-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:58:30Z","timestamp":1774342710000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10577-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":406,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10577"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10577-4","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"30 April 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}