{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:01:45Z","timestamp":1773982905186,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12602-025-10612-4","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T04:37:09Z","timestamp":1749271029000},"page":"1226-1233","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Evaluation of Lacticaseibacillus reuteri and Lacticaseibacillus rhamnosus Lysates for Oral Wound Healing"],"prefix":"10.1007","volume":"18","author":[{"given":"Zahra","family":"Harasani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaheh","family":"Ferdosi-Shahandashti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Najafzadehvarzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnaz","family":"Bakhshandeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliakbar","family":"Rajabzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasra","family":"Javadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"10612_CR1","doi-asserted-by":"publisher","first-page":"682143","DOI":"10.3389\/fcell.2021.682143","volume":"9","author":"D Pereira","year":"2021","unstructured":"Pereira D, Sequeira I (2021) A scarless healing tale: comparing homeostasis and wound healing of oral mucosa with skin and oesophagus. Front Cell Dev Biol 9:682143","journal-title":"Front Cell Dev Biol"},{"key":"10612_CR2","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.3390\/biom11081165","volume":"11","author":"M Waasdorp","year":"2021","unstructured":"Waasdorp M, Krom BP, Bikker FJ, van Zuijlen PP, Niessen FB, Gibbs S (2021) The bigger picture: why oral mucosa heals better than skin. Biomolecules 11:1165","journal-title":"Biomolecules"},{"key":"10612_CR3","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.3390\/molecules26103007","volume":"26","author":"R Zhao","year":"2021","unstructured":"Zhao R, Yang R, Cooper PR, Khurshid Z, Shavandi A, Ratnayake J (2021) Bone grafts and substitutes in dentistry: a review of current trends and developments. Molecules 26:3007","journal-title":"Molecules"},{"key":"10612_CR4","doi-asserted-by":"publisher","first-page":"125273","DOI":"10.1016\/j.ijbiomac.2023.125273","volume":"244","author":"X Dou","year":"2023","unstructured":"Dou X, Li G, Wang S, Shao D, Wang D, Deng X et al (2023) Probiotic-loaded calcium alginate\/fucoidan hydrogels for promoting oral ulcer healing. Int J Biol Macromol 244:125273","journal-title":"Int J Biol Macromol"},{"key":"10612_CR5","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/s41591-019-0439-x","volume":"25","author":"J Suez","year":"2019","unstructured":"Suez J, Zmora N, Segal E, Elinav E (2019) The pros, cons, and many unknowns of probiotics. Nat Med 25:716\u2013729","journal-title":"Nat Med"},{"key":"10612_CR6","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.3402\/jom.v1i0.1949","volume":"1","author":"DA Devine","year":"2009","unstructured":"Devine DA, Marsh PD (2009) Prospects for the development of probiotics and prebiotics for oral applications. J Oral Microbiol 1:1949","journal-title":"J Oral Microbiol"},{"key":"10612_CR7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12223-022-01030-y","volume":"68","author":"P Saravanan","year":"2023","unstructured":"Saravanan P, Pooja R, Balachander N, Kesav Ram Singh K, Silpa S, Rupachandra S (2023) Anti-inflammatory and wound healing properties of lactic acid bacteria and its peptides. Folia Microbiol 68:337\u2013353. https:\/\/doi.org\/10.1007\/s12223-022-01030-y","journal-title":"Folia Microbiol"},{"key":"10612_CR8","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.3390\/ijms25115723","volume":"25","author":"VA B\u0103d\u0103lu\u021b\u0103","year":"2024","unstructured":"B\u0103d\u0103lu\u021b\u0103 VA, Curu\u021biu C, Di\u021bu LM, Holban AM, Laz\u0103r V (2024) Probiotics in wound healing. Int J Mol Sci 25:5723","journal-title":"Int J Mol Sci"},{"key":"10612_CR9","doi-asserted-by":"publisher","first-page":"568636","DOI":"10.3389\/fimmu.2020.568636","volume":"11","author":"V Garcia-Castillo","year":"2020","unstructured":"Garcia-Castillo V, Tomokiyo M, Raya Tonetti F, Islam MA, Takahashi H, Kitazawa H, Villena J (2020) Alveolar macrophages are key players in the modulation of the respiratory antiviral immunity induced by orally administered Lacticaseibacillus rhamnosus CRL1505. Front Immunol 11:568636","journal-title":"Front Immunol"},{"key":"10612_CR10","doi-asserted-by":"publisher","first-page":"100136","DOI":"10.1016\/j.bioflm.2023.100136","volume":"6","author":"G Boisen","year":"2023","unstructured":"Boisen G, Prgomet Z, Enggren G, Dahl H, Mkadmi C, Davies JR (2023) Limosilactobacillus reuteri inhibits the acid tolerance response in oral bacteria. Biofilm 6:100136","journal-title":"Biofilm"},{"key":"10612_CR11","doi-asserted-by":"publisher","first-page":"8868618","DOI":"10.1155\/2020\/8868618","volume":"2020","author":"Y Ashoori","year":"2020","unstructured":"Ashoori Y, Mohkam M, Heidari R, Abootalebi SN, Mousavi SM, Hashemi SA et al (2020) Development and in vivo characterization of probiotic lysate-treated chitosan nanogel as a novel biocompatible formulation for wound healing. Biomed Res Int 2020:8868618","journal-title":"Biomed Res Int"},{"key":"10612_CR12","doi-asserted-by":"publisher","first-page":"16147","DOI":"10.1038\/srep16147","volume":"5","author":"W Mohammedsaeed","year":"2015","unstructured":"Mohammedsaeed W, Cruickshank S, McBain AJ, O\u2019Neill CA (2015) Lactobacillus rhamnosus GG lysate increases re-epithelialization of keratinocyte scratch assays by promoting migration. Sci Rep 5:16147","journal-title":"Sci Rep"},{"key":"10612_CR13","doi-asserted-by":"publisher","first-page":"5894","DOI":"10.1038\/s41598-025-86914-y","volume":"15","author":"SD Mercer","year":"2025","unstructured":"Mercer SD, Doherty C, Singh G, Willmott T, Cheesapcharoen T, Teanpaisan R et al (2025) Lactobacillus lysates protect oral epithelial cells from pathogen-associated damage, increase secretion of pro-inflammatory cytokines and enhance barrier integrity. Sci Rep 15:5894","journal-title":"Sci Rep"},{"key":"10612_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-019-1324-8","volume":"10","author":"N Han","year":"2019","unstructured":"Han N, Jia L, Su Y, Du J, Guo L, Luo Z, Liu Y (2019) Lactobacillus reuteri extracts promoted wound healing via PI3K\/AKT\/\u03b2-catenin\/TGF\u03b21 pathway. Stem Cell Res Ther 10:1\u201311","journal-title":"Stem Cell Res Ther"},{"key":"10612_CR15","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.injury.2022.02.006","volume":"53","author":"M Moysidis","year":"2022","unstructured":"Moysidis M, Stavrou G, Cheva A, Deka IA, Tsetis JK, Birba V et al (2022) The 3-D configuration of excisional skin wound healing after topical probiotic application. Injury 53:1385\u20131393","journal-title":"Injury"},{"key":"10612_CR16","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1089\/ten.tec.2024.0169","volume":"30","author":"E Kord-Parijaee","year":"2024","unstructured":"Kord-Parijaee E, Ferdosi-Shahandashti E, Bakhshandeh B, Pournajaf A (2024) Enhancing Gingival-derived mesenchymal stem cell potential in tissue engineering and regenerative medicine through paraprobiotics. Tissue Eng Part C Methods 30:512\u2013521","journal-title":"Tissue Eng Part C Methods"},{"key":"10612_CR17","doi-asserted-by":"publisher","unstructured":"Chen Z, Hui PC, Hui M, Yeoh YK, Wong PY, Chan MC et al (2019) Impact of preservation method and 16S rRNA hypervariable region on gut microbiota profiling. Msystems 4. https:\/\/doi.org\/10.1128\/msystems.00271-18","DOI":"10.1128\/msystems.00271-18"},{"key":"10612_CR18","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s12602-020-09713-z","volume":"13","author":"CF Moreira","year":"2021","unstructured":"Moreira CF, Cassini-Vieira P, Canesso MCC, Felipetto M, Ranfley H, Teixeira MM et al (2021) Lactobacillus rhamnosus CGMCC 1.3724 (LPR) improves skin wound healing and reduces scar formation in mice. Probiotics Antimicrob Proteins 13:709\u2013719","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10612_CR19","doi-asserted-by":"publisher","first-page":"20180150","DOI":"10.1515\/jbcpp-2018-0150","volume":"30","author":"Z Khodaii","year":"2019","unstructured":"Khodaii Z, Afrasiabi S, Hashemi SA, Ardeshirylajimi A, Natanzi MM (2019) Accelerated wound healing process in rat by probiotic Lactobacillus reuteri derived ointment. J Basic Clin Physiol Pharmacol 30:20180150","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"10612_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3390\/microorganisms9010069","volume":"9","author":"A Butera","year":"2020","unstructured":"Butera A, Gallo S, Maiorani C, Molino D, Chiesa A, Preda C et al (2020) Probiotic alternative to chlorhexidine in periodontal therapy: evaluation of clinical and microbiological parameters. Microorganisms 9:69","journal-title":"Microorganisms"},{"key":"10612_CR21","doi-asserted-by":"publisher","first-page":"539","DOI":"10.4103\/jisp.jisp_590_18","volume":"23","author":"L Boyeena","year":"2019","unstructured":"Boyeena L, Koduganti RR, Panthula VR, Jammula SP (2019) Comparison of efficacy of probiotics versus tetracycline fibers as adjuvants to scaling and root planing. J Indian Soc Periodontol 23:539\u2013544","journal-title":"J Indian Soc Periodontol"},{"key":"10612_CR22","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.3390\/nu13082666","volume":"13","author":"Y Nam","year":"2021","unstructured":"Nam Y, Kim J, Baek J, Kim W (2021) Improvement of cutaneous wound healing via topical application of heat-killed lactococcus chungangensis cau 1447 on diabetic mice. Nutrients 13:2666","journal-title":"Nutrients"},{"key":"10612_CR23","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.3390\/nu15081822","volume":"15","author":"D Panagiotou","year":"2023","unstructured":"Panagiotou D, Filidou E, Gaitanidou M, Tarapatzi G, Spathakis M, Kandilogiannakis L et al (2023) Role of Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 in the Wound Healing Process of the Excisional Skin. Nutrients 15:1822","journal-title":"Nutrients"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10612-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10612-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10612-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:31:19Z","timestamp":1773833479000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10612-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10612"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10612-4","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"23 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study met ethical standards regarding the use of laboratory animals, following the protocols outlined by the Ethics Committee of the Babol University of Medical Sciences, Babol, Iran (ethics code: IR.MUBABOL.REC.1401.126).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All the authors reviewed and approved the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}