{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:24:24Z","timestamp":1794108264900,"version":"4.8.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s12602-025-10650-y","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T09:51:28Z","timestamp":1755251488000},"page":"2699-2715","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Alginate Oligosaccharide Alleviates\u00a0Salmonella Typhimurium-Induced Liver Injury by Regulating\u00a0Oxidative Stress, Apoptosis, and Inflammatory Signaling Pathway"],"prefix":"10.1007","volume":"18","author":[{"given":"Yanan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"10650_CR1","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/j.1574-6976.2012.00332.x","volume":"36","author":"T Ruby","year":"2012","unstructured":"Ruby T, McLaughlin L, Gopinath S, Monack D (2012) Salmonella\u2019s long-term relationship with its host. FEMS Microbiol Rev 36:600\u201315. https:\/\/doi.org\/10.1111\/j.1574-6976.2012.00332.x","journal-title":"FEMS Microbiol Rev"},{"key":"10650_CR2","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1086\/650733","volume":"50","author":"SE Majowicz","year":"2010","unstructured":"Majowicz SE, Musto J, Scallan E, Angulo FJ, Kirk M et al (2010) The global burden of nontyphoidal Salmonella gastroenteritis. Clin Infect Dis 50:882\u20139. https:\/\/doi.org\/10.1086\/650733","journal-title":"Clin Infect Dis"},{"key":"10650_CR3","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.tim.2017.05.004","volume":"25","author":"R Gresse","year":"2017","unstructured":"Gresse R, Chaucheyras-Durand F, Fleury MA, Van de Wiele T, Forano E et al (2017) Gut microbiota dysbiosis in postweaning piglets: understanding the keys to health. Trends Microbiol 25:851\u2013873. https:\/\/doi.org\/10.1016\/j.tim.2017.05.004","journal-title":"Trends Microbiol"},{"key":"10650_CR4","doi-asserted-by":"publisher","unstructured":"Lamichhane B, Mawad AMM, Saleh M, Kelley WG, Harrington PJ 2nd et al (2024) Salmonellosis: an overview of epidemiology, pathogenesis, and innovative approaches to mitigate the antimicrobial resistant infections. Antibiotics (Basel) 13:76.\u00a0https:\/\/doi.org\/10.3390\/antibiotics13010076","DOI":"10.3390\/antibiotics13010076"},{"key":"10650_CR5","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1128\/cmr.00066-12","volume":"26","author":"A F\u00e0brega","year":"2013","unstructured":"F\u00e0brega A, Vila J (2013) Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulation. Clin Microbiol Rev 26:308\u201341. https:\/\/doi.org\/10.1128\/cmr.00066-12","journal-title":"Clin Microbiol Rev"},{"key":"10650_CR6","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.3389\/fmicb.2016.01827","volume":"7","author":"EV Gart","year":"2016","unstructured":"Gart EV, Suchodolski JS, Welsh TH Jr, Alaniz RC, Randel RD et al (2016) Salmonella Typhimurium and multidirectional communication in the gut. Front Microbiol 7:1827. https:\/\/doi.org\/10.3389\/fmicb.2016.01827","journal-title":"Front Microbiol"},{"key":"10650_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1146\/annurev.med.52.1.259","volume":"52","author":"ME Ohl","year":"2001","unstructured":"Ohl ME, Miller SI (2001) Salmonella: a model for bacterial pathogenesis. Annu Rev Med 52:259\u201374. https:\/\/doi.org\/10.1146\/annurev.med.52.1.259","journal-title":"Annu Rev Med"},{"key":"10650_CR8","doi-asserted-by":"publisher","unstructured":"Harrell JE, Hahn MM, D'Souza SJ, Vasicek EM, Sandala JL et al (2020) Salmonella biofilm formation, chronic infection, and immunity within the intestine and hepatobiliary tract. front cell infect microbiol 10: 624622. https:\/\/doi.org\/10.3389\/fcimb.2020.624622","DOI":"10.3389\/fcimb.2020.624622"},{"key":"10650_CR9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/cmi.2016.3","volume":"13","author":"MW Robinson","year":"2016","unstructured":"Robinson MW, Harmon C, O\u2019Farrelly C (2016) Liver immunology and its role in inflammation and homeostasis. Cell Mol Immunol 13:267\u201376. https:\/\/doi.org\/10.1038\/cmi.2016.3","journal-title":"Cell Mol Immunol"},{"key":"10650_CR10","doi-asserted-by":"publisher","first-page":"16194","DOI":"10.1038\/s41598-020-73208-8","volume":"10","author":"S Lorente","year":"2020","unstructured":"Lorente S, Hautefeuille M, Sanchez-Cedillo A (2020) The liver, a functionalized vascular structure. Sci Rep 10:16194. https:\/\/doi.org\/10.1038\/s41598-020-73208-8","journal-title":"Sci Rep"},{"key":"10650_CR11","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s42452-024-06151-2","volume":"6","author":"MM Rahman","year":"2024","unstructured":"Rahman MM, Shahid MA, Hossain MT, Sheikh MS, Rahman MS et al (2024) Sources, extractions, and applications of alginate: a review. Discover Appl Sci 6:443. https:\/\/doi.org\/10.1007\/s42452-024-06151-2","journal-title":"Discover Appl Sci"},{"key":"10650_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s11274-023-03658-5","volume":"39","author":"L Li","year":"2023","unstructured":"Li L, Jiang J, Yao Z, Zhu B (2023) Recent advances in the production, properties and applications of alginate oligosaccharides - a mini review. World J Microbiol Biotechnol 39:207. https:\/\/doi.org\/10.1007\/s11274-023-03658-5","journal-title":"World J Microbiol Biotechnol"},{"key":"10650_CR13","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.ijbiomac.2020.07.199","volume":"164","author":"D Cheng","year":"2020","unstructured":"Cheng D, Jiang C, Xu J, Liu Z, Mao X (2020) Characteristics and applications of alginate lyases: a review. Int J Biol Macromol 164:1304\u20131320. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.199","journal-title":"Int J Biol Macromol"},{"key":"10650_CR14","doi-asserted-by":"publisher","unstructured":"Guo JJ, Ma LL, Shi HT, Zhu JB, Wu J et al (2016) Alginate oligosaccharide prevents acute doxorubicin cardiotoxicity by suppressing oxidative stress and endoplasmic reticulum-mediated apoptosis. Mar Drugs 14. https:\/\/doi.org\/10.3390\/md14120231","DOI":"10.3390\/md14120231"},{"key":"10650_CR15","doi-asserted-by":"publisher","unstructured":"Hao Y, Fang H, Yan X, Shen W, Liu J et al (2023) Alginate oligosaccharides repair liver injury by improving anti-inflammatory capacity in a busulfan-induced mouse model. Int J Mol Sci 24. https:\/\/doi.org\/10.3390\/ijms24043097","DOI":"10.3390\/ijms24043097"},{"key":"10650_CR16","doi-asserted-by":"publisher","first-page":"107084","DOI":"10.1016\/j.intimp.2020.107084","volume":"89","author":"J Wan","year":"2020","unstructured":"Wan J, Zhang J, Yin H, Chen D, Yu B et al (2020) Ameliorative effects of alginate oligosaccharide on tumour necrosis factor-\u03b1-induced intestinal epithelial cell injury. Int Immunopharmacol 89:107084. https:\/\/doi.org\/10.1016\/j.intimp.2020.107084","journal-title":"Int Immunopharmacol"},{"key":"10650_CR17","doi-asserted-by":"publisher","first-page":"118316","DOI":"10.1016\/j.carbpol.2021.118316","volume":"270","author":"J Wan","year":"2021","unstructured":"Wan J, Zhang J, Xu Q, Yin H, Chen D et al (2021) Alginate oligosaccharide protects against enterotoxigenic Escherichia coli-induced porcine intestinal barrier injury. Carbohydr Polym 270:118316. https:\/\/doi.org\/10.1016\/j.carbpol.2021.118316","journal-title":"Carbohydr Polym"},{"key":"10650_CR18","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.foodchem.2014.05.053","volume":"164","author":"M Falkeborg","year":"2014","unstructured":"Falkeborg M, Cheong LZ, Gianfico C, Sztukiel KM, Kristensen K et al (2014) Alginate oligosaccharides: enzymatic preparation and antioxidant property evaluation. Food Chem 164:185\u201394. https:\/\/doi.org\/10.1016\/j.foodchem.2014.05.053","journal-title":"Food Chem"},{"key":"10650_CR19","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/s1499-3872(16)60113-3","volume":"15","author":"YT Li","year":"2016","unstructured":"Li YT, Yu CB, Yan D, Huang JR, Li LJ (2016) Effects of Salmonella infection on hepatic damage following acute liver injury in rats. Hepatobiliary Pancreat Dis Int 15:399\u2013405. https:\/\/doi.org\/10.1016\/s1499-3872(16)60113-3","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10650_CR20","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1574-6941.2009.00703.x","volume":"69","author":"P Rishi","year":"2009","unstructured":"Rishi P, Mavi SK, Bharrhan S, Shukla G, Tewari R (2009) Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage. FEMS Microbiol Ecol 69:222\u201330. https:\/\/doi.org\/10.1111\/j.1574-6941.2009.00703.x","journal-title":"FEMS Microbiol Ecol"},{"key":"10650_CR21","doi-asserted-by":"publisher","unstructured":"Wang R, Li S, Jia H, Si X, Lei Y et al (2021) Protective effects of cinnamaldehyde on the inflammatory response, oxidative stress, and apoptosis in liver of Salmonella typhimurium-challenged mice. Molecules 26. https:\/\/doi.org\/10.3390\/molecules26082309","DOI":"10.3390\/molecules26082309"},{"key":"10650_CR22","doi-asserted-by":"publisher","unstructured":"Zhang Y, Guo C, Li Y, Han X, Luo X et al (2022) Alginate oligosaccharides ameliorate dss-induced colitis through modulation of AMPK\/NF-\u03baB pathway and intestinal microbiota. Nutrients 14. https:\/\/doi.org\/10.3390\/nu14142864","DOI":"10.3390\/nu14142864"},{"key":"10650_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","volume":"125","author":"T McGarry","year":"2018","unstructured":"McGarry T, Biniecka M, Veale DJ, Fearon U (2018) Hypoxia, oxidative stress and inflammation. Free Radic Biol Med 125:15\u201324. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.03.042","journal-title":"Free Radic Biol Med"},{"key":"10650_CR24","doi-asserted-by":"publisher","first-page":"102553","DOI":"10.1016\/j.redox.2022.102553","volume":"58","author":"X Shi","year":"2022","unstructured":"Shi X, Zhou H, Wei J, Mo W, Li Q et al (2022) The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases. Redox Biol 58:102553. https:\/\/doi.org\/10.1016\/j.redox.2022.102553","journal-title":"Redox Biol"},{"key":"10650_CR25","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","volume":"73","author":"A Loboda","year":"2016","unstructured":"Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J (2016) Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci 73:3221\u201347. https:\/\/doi.org\/10.1007\/s00018-016-2223-0","journal-title":"Cell Mol Life Sci"},{"key":"10650_CR26","doi-asserted-by":"publisher","first-page":"110074","DOI":"10.1016\/j.biopha.2020.110074","volume":"126","author":"B Li","year":"2020","unstructured":"Li B, Nasser MI, Masood M, Adlat S, Huang Y et al (2020) Efficiency of traditional Chinese medicine targeting the Nrf2\/HO-1 signaling pathway. Biomed Pharmacother 126:110074. https:\/\/doi.org\/10.1016\/j.biopha.2020.110074","journal-title":"Biomed Pharmacother"},{"key":"10650_CR27","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","volume":"18","author":"D Bertheloot","year":"2021","unstructured":"Bertheloot D, Latz E, Franklin BS (2021) Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol Immunol 18:1106\u20131121. https:\/\/doi.org\/10.1038\/s41423-020-00630-3","journal-title":"Cell Mol Immunol"},{"key":"10650_CR28","doi-asserted-by":"publisher","first-page":"167378","DOI":"10.1016\/j.jmb.2021.167378","volume":"434","author":"N Ketelut-Carneiro","year":"2022","unstructured":"Ketelut-Carneiro N, Fitzgerald KA (2022) Apoptosis, pyroptosis, and necroptosis-oh my! The many ways a cell can die. J Mol Biol 434:167378. https:\/\/doi.org\/10.1016\/j.jmb.2021.167378","journal-title":"J Mol Biol"},{"key":"10650_CR29","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/sj.cdd.4400783","volume":"7","author":"SJ Korsmeyer","year":"2000","unstructured":"Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ et al (2000) Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 7:1166\u201373. https:\/\/doi.org\/10.1038\/sj.cdd.4400783","journal-title":"Cell Death Differ"},{"key":"10650_CR30","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.tibs.2011.08.009","volume":"36","author":"LD Walensky","year":"2011","unstructured":"Walensky LD, Gavathiotis E (2011) BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. Trends Biochem Sci 36:642\u201352. https:\/\/doi.org\/10.1016\/j.tibs.2011.08.009","journal-title":"Trends Biochem Sci"},{"key":"10650_CR31","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/bab.2233","volume":"69","author":"M Asadi","year":"2022","unstructured":"Asadi M, Taghizadeh S, Kaviani E, Vakili O, Taheri-Anganeh M et al (2022) Caspase-3: structure, function, and biotechnological aspects. Biotechnol Appl Biochem 69:1633\u20131645. https:\/\/doi.org\/10.1002\/bab.2233","journal-title":"Biotechnol Appl Biochem"},{"key":"10650_CR32","doi-asserted-by":"publisher","unstructured":"Silva F, Pad\u00edn-Iruegas ME, Caponio VCA, Lorenzo-Pouso AI, Saavedra-Nieves P et al (2022) Caspase 3 and cleaved caspase 3 expression in tumorogenesis and its correlations with prognosis in head and neck cancer: a systematic review and meta-analysis. Int J Mol Sci 23. https:\/\/doi.org\/10.3390\/ijms231911937","DOI":"10.3390\/ijms231911937"},{"key":"10650_CR33","doi-asserted-by":"publisher","unstructured":"Wang L, Zhao X, Xia X, Zhu C, Zhang H et al (2019) Inhibitory effects of antimicrobial peptide JH-3 on Salmonella enterica serovar Typhimurium strain CVCC541 infection-induced inflammatory cytokine release and apoptosis in RAW264.7 Cells. Molecules 24. https:\/\/doi.org\/10.3390\/molecules24030596","DOI":"10.3390\/molecules24030596"},{"key":"10650_CR34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40104-018-0273-x","volume":"9","author":"J Wan","year":"2018","unstructured":"Wan J, Zhang J, Chen D, Yu B, Mao X et al (2018) Alginate oligosaccharide-induced intestinal morphology, barrier function and epithelium apoptosis modifications have beneficial effects on the growth performance of weaned pigs. J Anim Sci Biotechnol 9:58. https:\/\/doi.org\/10.1186\/s40104-018-0273-x","journal-title":"J Anim Sci Biotechnol"},{"key":"10650_CR35","doi-asserted-by":"publisher","first-page":"5438","DOI":"10.1016\/j.biomaterials.2011.04.024","volume":"32","author":"SK Tusi","year":"2011","unstructured":"Tusi SK, Khalaj L, Ashabi G, Kiaei M, Khodagholi F (2011) Alginate oligosaccharide protects against endoplasmic reticulum- and mitochondrial-mediated apoptotic cell death and oxidative stress. Biomaterials 32:5438\u201358. https:\/\/doi.org\/10.1016\/j.biomaterials.2011.04.024","journal-title":"Biomaterials"},{"key":"10650_CR36","doi-asserted-by":"publisher","unstructured":"Qiu X, Yin F, Du C, Ma J, Gan S (2024) Alginate oligosaccharide alleviates lipopolysaccharide-induced apoptosis and inflammatory response of rumen epithelial cells through NF-\u03baB signaling pathway. Animals (Basel) 14. https:\/\/doi.org\/10.3390\/ani14091298","DOI":"10.3390\/ani14091298"},{"key":"10650_CR37","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1189\/jlb.1105672","volume":"80","author":"SM Miggin","year":"2006","unstructured":"Miggin SM, O\u2019Neill LA (2006) New insights into the regulation of TLR signaling. J Leukoc Biol 80:220\u20136. https:\/\/doi.org\/10.1189\/jlb.1105672","journal-title":"J Leukoc Biol"},{"key":"10650_CR38","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cell.2011.01.031","volume":"144","author":"N Arpaia","year":"2011","unstructured":"Arpaia N, Godec J, Lau L, Sivick KE, McLaughlin LM et al (2011) TLR signaling is required for Salmonella typhimurium virulence. Cell 144:675\u201388. https:\/\/doi.org\/10.1016\/j.cell.2011.01.031","journal-title":"Cell"},{"key":"10650_CR39","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s12016-013-8402-y","volume":"47","author":"Y Liu","year":"2014","unstructured":"Liu Y, Yin H, Zhao M, Lu Q (2014) TLR2 and TLR4 in autoimmune diseases: a comprehensive review. Clin Rev Allergy Immunol 47:136\u201347. https:\/\/doi.org\/10.1007\/s12016-013-8402-y","journal-title":"Clin Rev Allergy Immunol"},{"key":"10650_CR40","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","volume":"13","author":"T Kawai","year":"2007","unstructured":"Kawai T, Akira S (2007) Signaling to NF-kappaB by toll-like receptors. Trends Mol Med 13:460\u20139. https:\/\/doi.org\/10.1016\/j.molmed.2007.09.002","journal-title":"Trends Mol Med"},{"key":"10650_CR41","doi-asserted-by":"publisher","unstructured":"Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1: a001651. https:\/\/doi.org\/10.1101\/cshperspect.a001651","DOI":"10.1101\/cshperspect.a001651"},{"key":"10650_CR42","doi-asserted-by":"publisher","first-page":"133699","DOI":"10.1016\/j.ijbiomac.2024.133699","volume":"276","author":"Y Teng","year":"2024","unstructured":"Teng Y, Li J, Guo J, Yan C, Wang A et al (2024) Alginate oligosaccharide improves 5-fluorouracil-induced intestinal mucositis by enhancing intestinal barrier and modulating intestinal levels of butyrate and isovalerate. Int J Biol Macromol 276:133699. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.133699","journal-title":"Int J Biol Macromol"},{"key":"10650_CR43","doi-asserted-by":"publisher","first-page":"13482","DOI":"10.1039\/c8ra01943f","volume":"8","author":"J Wan","year":"2018","unstructured":"Wan J, Zhang J, Chen D, Yu B, Huang Z et al (2018) Alginate oligosaccharide enhances intestinal integrity of weaned pigs through altering intestinal inflammatory responses and antioxidant status. RSC Adv 8:13482\u201313492. https:\/\/doi.org\/10.1039\/c8ra01943f","journal-title":"RSC Adv"},{"key":"10650_CR44","doi-asserted-by":"publisher","first-page":"13415","DOI":"10.1021\/acs.jafc.4c03019","volume":"72","author":"J Li","year":"2024","unstructured":"Li J, Liu H, Fu H, Yang Y, Wu Z (2024) An isofibrous diet with fiber konjac glucomannan ameliorates Salmonella typhimurium-induced colonic injury by regulating TLR2-NF-\u03baB signaling and intestinal microbiota in mice. J Agric Food Chem 72:13415\u201313430. https:\/\/doi.org\/10.1021\/acs.jafc.4c03019","journal-title":"J Agric Food Chem"},{"key":"10650_CR45","doi-asserted-by":"publisher","unstructured":"Pang J, Wang S, Wang Z, Wu Y, Zhang X et al (2021) Xylo-oligosaccharide alleviates Salmonella induced inflammation by stimulating Bifidobacterium animalis and inhibiting Salmonella colonization. Faseb j 35: e21977. https:\/\/doi.org\/10.1096\/fj.202100919RR","DOI":"10.1096\/fj.202100919RR"},{"key":"10650_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jare.2023.03.001","volume":"56","author":"Y Wu","year":"2024","unstructured":"Wu Y, Zhang X, Liu X, Li Y, Han D et al (2024) Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection. J Adv Res 56:1\u201314. https:\/\/doi.org\/10.1016\/j.jare.2023.03.001","journal-title":"J Adv Res"},{"key":"10650_CR47","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.3389\/fmicb.2019.02037","volume":"10","author":"S Gupta","year":"2019","unstructured":"Gupta S, Lokesh J, Abdelhafiz Y, Siriyappagouder P, Pierre R et al (2019) Macroalga-derived alginate oligosaccharide alters intestinal bacteria of Atlantic salmon. Front Microbiol 10:2037. https:\/\/doi.org\/10.3389\/fmicb.2019.02037","journal-title":"Front Microbiol"},{"key":"10650_CR48","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1136\/gutjnl-2023-330365","volume":"73","author":"E Medawar","year":"2024","unstructured":"Medawar E, Beyer F, Thieleking R, Haange SB, Rolle-Kampczyk U et al (2024) Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial. Gut 73:298\u2013310. https:\/\/doi.org\/10.1136\/gutjnl-2023-330365","journal-title":"Gut"},{"key":"10650_CR49","doi-asserted-by":"publisher","unstructured":"Stojanov S, Berlec A, \u0160trukelj B (2020) The influence of probiotics on the firmicutes\/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease. Microorganisms 8. https:\/\/doi.org\/10.3390\/microorganisms8111715","DOI":"10.3390\/microorganisms8111715"},{"key":"10650_CR50","doi-asserted-by":"publisher","first-page":"e2100955","DOI":"10.1002\/mnfr.202100955","volume":"66","author":"X Si","year":"2022","unstructured":"Si X, Jia H, Liu N, Li J, Pan L et al (2022) Alpha-ketoglutarate attenuates colitis in mice by increasing Lactobacillus abundance and regulating stem cell proliferation via Wnt-hippo signaling. Mol Nutr Food Res 66:e2100955. https:\/\/doi.org\/10.1002\/mnfr.202100955","journal-title":"Mol Nutr Food Res"},{"key":"10650_CR51","doi-asserted-by":"publisher","first-page":"728929","DOI":"10.3389\/fcimb.2021.728929","volume":"11","author":"Y Liu","year":"2021","unstructured":"Liu Y, Zhou M, Yang M, Jin C, Song Y et al (2021) Pulsatilla chinensis saponins ameliorate inflammation and DSS-induced ulcerative colitis in rats by regulating the composition and diversity of intestinal flora. Front Cell Infect Microbiol 11:728929. https:\/\/doi.org\/10.3389\/fcimb.2021.728929","journal-title":"Front Cell Infect Microbiol"},{"key":"10650_CR52","doi-asserted-by":"publisher","first-page":"117990","DOI":"10.1016\/j.jep.2024.117990","volume":"326","author":"Y Luo","year":"2024","unstructured":"Luo Y, Fu S, Liu Y, Kong S, Liao Q et al (2024) Banxia Xiexin decoction modulates gut microbiota and gut microbiota metabolism to alleviate DSS-induced ulcerative colitis. J Ethnopharmacol 326:117990. https:\/\/doi.org\/10.1016\/j.jep.2024.117990","journal-title":"J Ethnopharmacol"},{"key":"10650_CR53","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s12672-024-01393-3","volume":"15","author":"J Fu","year":"2024","unstructured":"Fu J, Li G, Li X, Song S, Cheng L et al (2024) Gut commensal alistipes as a potential pathogenic factor in colorectal cancer. Discov Oncol 15:473. https:\/\/doi.org\/10.1007\/s12672-024-01393-3","journal-title":"Discov Oncol"},{"key":"10650_CR54","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.3748\/wjg.v19.i28.4576","volume":"19","author":"Z Xiang","year":"2013","unstructured":"Xiang Z, Chen YP, Ye YF, Ma KF, Chen SH et al (2013) Helicobacter pylori and Crohn\u2019s disease: a retrospective single-center study from China. World J Gastroenterol 19:4576\u201381. https:\/\/doi.org\/10.3748\/wjg.v19.i28.4576","journal-title":"World J Gastroenterol"},{"key":"10650_CR55","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1093\/jn\/nxab250","volume":"151","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Mu T, Yang Y, Zhang J, Ren F et al (2021) Lactobacillus johnsonii attenuates Citrobacter rodentium-induced colitis by regulating inflammatory responses and endoplasmic reticulum stress in mice. J Nutr 151:3391\u20133399. https:\/\/doi.org\/10.1093\/jn\/nxab250","journal-title":"J Nutr"},{"key":"10650_CR56","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12929-023-00958-8","volume":"30","author":"CM Chen","year":"2023","unstructured":"Chen CM, Yang YSH, Chou HC, Lin S (2023) Intranasal administration of Lactobacillus johnsonii attenuates hyperoxia-induced lung injury by modulating gut microbiota in neonatal mice. J Biomed Sci 30:57. https:\/\/doi.org\/10.1186\/s12929-023-00958-8","journal-title":"J Biomed Sci"},{"key":"10650_CR57","doi-asserted-by":"publisher","first-page":"134643","DOI":"10.1016\/j.foodchem.2022.134643","volume":"404","author":"Z Lin","year":"2023","unstructured":"Lin Z, Wu J, Wang J, Levesque CL, Ma X (2023) Dietary Lactobacillus reuteri prevent from inflammation mediated apoptosis of liver via improving intestinal microbiota and bile acid metabolism. Food Chem 404:134643. https:\/\/doi.org\/10.1016\/j.foodchem.2022.134643","journal-title":"Food Chem"},{"key":"10650_CR58","doi-asserted-by":"publisher","unstructured":"Cheng J, Xiao M, Ren X, Secundo F, Yu Y et al (2023) Response of Salmonella enterica serovar Typhimurium to alginate oligosaccharides fermented with fecal inoculum: integrated transcriptomic and metabolomic analyses. Mar Life Sci Technol 5:242\u2013256.\u00a0https:\/\/doi.org\/10.1007\/s42995-023-00176-z","DOI":"10.1007\/s42995-023-00176-z"},{"key":"10650_CR59","doi-asserted-by":"publisher","first-page":"119043","DOI":"10.1016\/j.carbpol.2021.119043","volume":"284","author":"N Zhang","year":"2022","unstructured":"Zhang N, Jin M, Wang K, Zhang Z, Shah NP et al (2022) Functional oligosaccharide fermentation in the gut: improving intestinal health and its determinant factors\u2014a review. Carbohydr Polym 284:119043. https:\/\/doi.org\/10.1016\/j.carbpol.2021.119043","journal-title":"Carbohydr Polym"},{"key":"10650_CR60","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1039\/c7fo00031f","volume":"8","author":"L Wang","year":"2017","unstructured":"Wang L, Hu L, Yan S, Jiang T, Fang S et al (2017) Effects of different oligosaccharides at various dosages on the composition of gut microbiota and short-chain fatty acids in mice with constipation. Food Funct 8:1966\u20131978. https:\/\/doi.org\/10.1039\/c7fo00031f","journal-title":"Food Funct"},{"key":"10650_CR61","doi-asserted-by":"publisher","first-page":"108273","DOI":"10.1016\/j.pharmthera.2022.108273","volume":"239","author":"T Ikeda","year":"2022","unstructured":"Ikeda T, Nishida A, Yamano M, Kimura I (2022) Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases. Pharmacol Ther 239:108273. https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108273","journal-title":"Pharmacol Ther"},{"key":"10650_CR62","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1574-6941.2002.tb00907.x","volume":"39","author":"LJ Fooks","year":"2002","unstructured":"Fooks LJ, Gibson GR (2002) In vitro investigations of the effect of probiotics and prebiotics on selected human intestinal pathogens. FEMS Microbiol Ecol 39:67\u201375. https:\/\/doi.org\/10.1111\/j.1574-6941.2002.tb00907.x","journal-title":"FEMS Microbiol Ecol"},{"key":"10650_CR63","doi-asserted-by":"publisher","first-page":"14951","DOI":"10.1021\/acs.jafc.3c00278","volume":"71","author":"Z Wu","year":"2023","unstructured":"Wu Z, He J, Zhang Z, Li J, Zou H et al (2023) Propionic acid driven by the Lactobacillus johnsonii culture supernatant alleviates colitis by inhibiting M1 macrophage polarization by modulating the MAPK pathway in mice. J Agric Food Chem 71:14951\u201314966. https:\/\/doi.org\/10.1021\/acs.jafc.3c00278","journal-title":"J Agric Food Chem"},{"key":"10650_CR64","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1093\/jn\/nxz088","volume":"149","author":"Y Cui","year":"2019","unstructured":"Cui Y, Qi S, Zhang W, Mao J, Tang R et al (2019) Lactobacillus reuteri ZJ617 culture supernatant attenuates acute liver injury induced in mice by lipopolysaccharide. J Nutr 149:2046\u20132055. https:\/\/doi.org\/10.1093\/jn\/nxz088","journal-title":"J Nutr"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10650-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10650-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10650-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:58:00Z","timestamp":1774342680000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10650-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10650"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10650-y","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"26 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}