{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:06:12Z","timestamp":1790208372280,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s12602-025-10710-3","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T09:46:16Z","timestamp":1755251176000},"page":"3281-3302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Probiotics on Markers of Oxidative\/Nitrosative Stress and Damage Associated with Inflammation in Non-communicable Diseases: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials"],"prefix":"10.1007","volume":"18","author":[{"given":"Natanny Swerts","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7242-8028","authenticated-orcid":false,"given":"Cl\u00e1udio Daniel","family":"Cerdeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Marques","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"10710_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13098-018-0353-2","volume":"10","author":"F Raygan","year":"2018","unstructured":"Raygan F, Rezavandi Z, Bahmani F, Ostadmohammadi V, Ali Mansournia M, Tajabadi-Ebrahimi M, Borzabadi S, Asemi Z (2018) The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease. Diabetol Metab Syndr 10:51","journal-title":"Diabetol Metab Syndr"},{"key":"10710_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12876-021-01660-5","volume":"21","author":"PL Chong","year":"2021","unstructured":"Chong PL, Laight D, Aspinall RJ, Higginson A, Cummings MH (2021) A randomised placebo controlled trial of VSL#3\u00ae probiotic on biomarkers of cardiovascular risk and liver injury in non-alcoholic fatty liver disease. BMC Gastroenterol 21:144","journal-title":"BMC Gastroenterol"},{"key":"10710_CR3","doi-asserted-by":"publisher","unstructured":"Natarajan R, Pechenyak B, Vyas U, Ranganathan P, Weinberg A, Liang P, Mallappallil MC, Norin AJ, Friedman EA, Saggi SJ (2014) Randomized controlled trial of strain-specific probiotic formulation (Renadyl) in dialysis patients. Biomed Res Int 2014:568571. https:\/\/doi.org\/10.1155\/2014\/568571","DOI":"10.1155\/2014\/568571"},{"issue":"5","key":"10710_CR4","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.3390\/biomedicines11051388","volume":"11","author":"C Kunst","year":"2023","unstructured":"Kunst C, Schmid S, Michalski M et al (2023) The influence of gut microbiota on oxidative stress and the immune system. Biomedicines 11(5):1388","journal-title":"Biomedicines"},{"issue":"4","key":"10710_CR5","first-page":"326","volume":"8","author":"S Mahmoudi","year":"2021","unstructured":"Mahmoudi S, Ghane MR, Goodarzi H, Faraji M, Shahjooie F, Javadzadeh HR (2021) The effect of probiotic supplements on oxidative stress in various diseases: a systematic review. J Appl Biotechnol Rep 8(4):326\u2013331","journal-title":"J Appl Biotechnol Rep"},{"key":"10710_CR6","doi-asserted-by":"crossref","unstructured":"Cryan JF, O\u2019Riordan KJ, Cowan CSM et al (2013) The microbiota-gut-brain axis. Physiol Rev 99:1877\u2013201","DOI":"10.1152\/physrev.00018.2018"},{"key":"10710_CR7","doi-asserted-by":"publisher","first-page":"18577","DOI":"10.1038\/s41598-023-46047-6","volume":"13","author":"KM Asghari","year":"2023","unstructured":"Asghari KM, Dolatkhah N, Ayromlou H, Mirnasiri F, Dadfar T, Hashemian M (2023) The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: a randomized clinical trial. Sci Rep 13:18577","journal-title":"Sci Rep"},{"key":"10710_CR8","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","volume":"17","author":"MS Cooke","year":"2003","unstructured":"Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17:1195\u20131214","journal-title":"FASEB J"},{"issue":"5","key":"10710_CR9","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1007\/s10787-023-01332-8","volume":"31","author":"AH Faghfouri","year":"2023","unstructured":"Faghfouri AH, Afrakoti LGMP, Kavyani Z, Nogourani ZS, Musazadeh V, Jafarlou M, Dehghan P (2023) The role of probiotic supplementation in inflammatory biomarkers in adults: an umbrella meta-analysis of randomized controlled trials. Inflammopharmacol 31(5):2253\u20132268","journal-title":"Inflammopharmacol"},{"key":"10710_CR10","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova K, Raptova R, Alomar SY et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol 97:2499\u20132574","journal-title":"Arch Toxicol"},{"key":"10710_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00662","volume":"9","author":"A Agahi","year":"2018","unstructured":"Agahi A, Hamidi GA, Daneshvar R et al (2018) Does severity of Alzheimer\u2019s disease contribute to its responsiveness to modifying gut microbiota? A double blind clinical trial. Front Neurol 9:662","journal-title":"Front Neurol"},{"key":"10710_CR12","doi-asserted-by":"crossref","unstructured":"Tamtaji OR, Taghizadeh M, Kakhaki DR, Kouchaki E, Bahmani F et al (2019) Clinical and metabolic response to probiotic administration in people with Parkinson\u2019s disease: a randomized, double-blind, placebo-controlled trial. Clin Nut 38:1031e1035","DOI":"10.1016\/j.clnu.2018.05.018"},{"key":"10710_CR13","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1007\/s10787-023-01427-2","volume":"32","author":"C Akhgarjand","year":"2024","unstructured":"Akhgarjand C, Vahabi V, Shab-Bidar S, Anoushirvani A, Djafarian K (2024) The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer\u2019s disease: a randomized, double-blind, placebo-controlled study. Inflammopharmacology 32:1413\u20131420","journal-title":"Inflammopharmacology"},{"key":"10710_CR14","doi-asserted-by":"crossref","unstructured":"Hsu YC, Huang YY, Tsai SY, Kuo YW, Lin JH et al (2024) Efficacy of probiotic supplements on brain-derived neurotrophic factor, inflammatory biomarkers, oxidative stress and cognitive function in patients with Alzheimer\u2019s dementia: a 12 week randomized, double-blind active-controlled study. Nutrients 16:16","DOI":"10.3390\/nu16010016"},{"issue":"3","key":"10710_CR15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.nut.2015.09.003","volume":"32","author":"G Akkasheh","year":"2016","unstructured":"Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M et al (2016) Clinical and metabolic response to probiotic administration in patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial. Nutrition 32(3):315\u2013320","journal-title":"Nutrition"},{"key":"10710_CR16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/PRA.0000000000000660","volume":"28","author":"S Sabouri","year":"2022","unstructured":"Sabouri S, Esmailzadeh M, Sadeghinejad A, Shahrbabaki Me, Asadikaram G, Nikvarz N (2022) The effect of adjunctive probiotics on markers of inflammation and oxidative stress in bipolar disorder: a double-blind, randomized, controlled trial. J Psychiatr Pract 28:373\u2013382","journal-title":"J Psychiatr Pract"},{"key":"10710_CR17","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jjcc.2022.06.006","volume":"80","author":"A Karim","year":"2022","unstructured":"Karim A, Muhammad T, Shah I, Khan J, Qaisar R (2022) A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure. J Cardiol 80:449\u2013455","journal-title":"J Cardiol"},{"issue":"4","key":"10710_CR18","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.nut.2013.09.007","volume":"30","author":"E Vaghef-Mehrabany","year":"2014","unstructured":"Vaghef-Mehrabany E, Alipour B, Homayouni-Rad A, Sharif SK, Asghari-Jafarabadi M, Zavvari S (2014) Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis. Nutrition 30(4):430\u2013435","journal-title":"Nutrition"},{"key":"10710_CR19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/07315724.2014.959208","volume":"35","author":"E Vaghef-Mehrabany","year":"2016","unstructured":"Vaghef-Mehrabany E, Homayouni-Rad A, Alipour B, Sharif S-K, Vaghef-Mehrabany L, Alipour-Ajiry S (2016) Effects of probiotic supplementation on oxidative stress indices in women with rheumatoid arthritis: a randomized double-blind clinical trial. J Am Coll Nutr 35:291\u2013299","journal-title":"J Am Coll Nutr"},{"key":"10710_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000349922","volume":"63","author":"Z Asemi","year":"2013","unstructured":"Asemi Z, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A (2013) Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Ann Nutr Metab 63:1\u20139","journal-title":"Ann Nutr Metab"},{"issue":"5","key":"10710_CR21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1053\/j.jrn.2017.04.004","volume":"27","author":"M Miraghajani","year":"2017","unstructured":"Miraghajani M, Zaghian N, Mirlohi M, Feizi A, Ghiasvand R (2017) The impact of probiotic soy milk consumption on oxidative stress among type 2 diabetic kidney disease patients: a randomized controlled clinical trial. J Ren Nutr 27(5):317\u2013324","journal-title":"J Ren Nutr"},{"key":"10710_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.kint.2016.09.040","volume":"91","author":"A Soleimani","year":"2017","unstructured":"Soleimani A, Mojarrad MZ, Bahmani F, Taghizadeh M, Ramezani M, Tajabadi-Ebrahimi M, Jafari P, Esmaillzadeh A, Asemi Z (2017) Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects. Kidney Int 91:435\u2013442","journal-title":"Kidney Int"},{"issue":"3","key":"10710_CR23","first-page":"581","volume":"27","author":"M Hajifaraji","year":"2018","unstructured":"Hajifaraji M, Jahanjou F, Abbasalizadeh F, Aghamohammadzadeh N, Abbasi MM, Dolatkhah N (2018) Effect of probiotic supplements in women with gestational diabetes mellitus on inflammation and oxidative stress biomarkers: a randomized clinical trial. Asia Pac J Clin Nutr 27(3):581\u2013591","journal-title":"Asia Pac J Clin Nutr"},{"key":"10710_CR24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neubiorev.2014.05.007","volume":"45","author":"S Moylan","year":"2014","unstructured":"Moylan S, Berk M, Dean OM et al (2014) Oxidative & nitrosative stress in depression: why so much stress? Neurosci Biobehav Rev 45:46\u201362","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"10710_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12602-019-09559-0","volume":"14","author":"R Tabrizi","year":"2019","unstructured":"Tabrizi R, Ostadmohammadi V, Akbari M et al (2019) The effects of probiotic supplementation on clinical symptom, weight loss, glycemic control, lipid and hormonal profiles, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Probiotics Antimicrob Proteins 14(1):1\u201314","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10710_CR26","doi-asserted-by":"publisher","first-page":"e05925","DOI":"10.1016\/j.heliyon.2021.e05925","volume":"7","author":"J Bohlouli","year":"2021","unstructured":"Bohlouli J, Namjoo I, Borzoo-Isfahani M et al (2021) Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: a systematic review and meta-analysis of clinical trials. Heliyon 7:e05925","journal-title":"Heliyon"},{"key":"10710_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.757673","volume":"8","author":"X Li","year":"2021","unstructured":"Li X, Lv C, Song J, Li J (2021) Effect of probiotic supplementation on cognitive function and metabolic status in mild cognitive impairment and Alzheimer\u2019s disease: a meta-analysis. Front Nutr 8:757673","journal-title":"Front Nutr"},{"key":"10710_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194456","volume":"10","author":"TTU Nguyen","year":"2021","unstructured":"Nguyen TTU, Kim HW, Kim W (2021) Effects of probiotics, prebiotics, and synbiotics on uremic toxins, inflammation, and oxidative stress in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trial. J Clin Med 10:4456","journal-title":"J Clin Med"},{"key":"10710_CR29","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1080\/0886022X.2022.2079522","volume":"44","author":"Y Dai","year":"2022","unstructured":"Dai Y, Quan J, Xiong L, Luo Y, Yi B (2022) Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis. Ren Fail 44:862\u2013880","journal-title":"Ren Fail"},{"key":"10710_CR30","doi-asserted-by":"crossref","unstructured":"Naseri K, Saadati S, Ghaemi F et al (2023) The effects of\u00a0probiotic and\u00a0symbiotic supplementation on\u00a0inflammation, oxidative stress, and\u00a0circulating adiponectin and\u00a0leptin concentration in\u00a0subjects with\u00a0prediabetes and\u00a0type 2 diabetes mellitus: a\u00a0GRADE-assessed systematic review, meta-analysis, and\u00a0meta-regression of\u00a0randomized clinical trials. Eur J Nutr 62:543\u2013561","DOI":"10.1007\/s00394-022-03012-9"},{"key":"10710_CR31","unstructured":"Cerdeira CD, Silva NS, dos Reis TM, Rodrigues MR (2023) Efficacy of probiotics on gut microbiome alpha-diversity and inflammatory markers in patients with inflammatory bowel disease: systematic review and meta-analysis of randomized controlled trials. PROSPERO CRD42023440106"},{"key":"10710_CR32","doi-asserted-by":"crossref","unstructured":"Higgins JP, Altman DG, G\u00f8tzsche PC, J\u00fcni P, Moher D, Oxman AD, Savovi\u0107 J, Schulz KF, Weeks L, Sterne JA (2011) The cochrane collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ 343:d5928","DOI":"10.1136\/bmj.d5928"},{"key":"10710_CR33","unstructured":"Higgins JPT, Green S (eds) (2011) Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration,\u00a0UK, Ed. Wiley"},{"issue":"2","key":"10710_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1056\/EVIDoa2200234","volume":"2","author":"M Paton","year":"2023","unstructured":"Paton M, Chan S, Tipping CJ, Stratton A, Neto AS et al (2023) The effect of mobilization at 6 months after critical illness \u2013 meta-analysis. NEJM Evid 2(2):12","journal-title":"NEJM Evid"},{"key":"10710_CR35","doi-asserted-by":"crossref","unstructured":"Maru\u0161i\u0107 MF, Fidahi\u0107 M, Cepeha CM, Farcas LG, Tseke A et al (2020) Methodological tools and sensitivity analysis for assessing quality or risk of bias used in systematic reviews published in the high-impact anesthesiology journals. BMC Med Res Methodol 20:121","DOI":"10.1186\/s12874-020-00966-4"},{"key":"10710_CR36","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jrsm.1260","volume":"8","author":"R Suurmond","year":"2017","unstructured":"Suurmond R, Rhee R, Hak T (2017) Introduction, comparison and validation of meta-essentials: a free and simple tool for meta-analysis. Res Synth Methods 8:537\u2013553","journal-title":"Res Synth Methods"},{"key":"10710_CR37","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","volume":"4","author":"D Lakens","year":"2013","unstructured":"Lakens D (2013) Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol 4:863","journal-title":"Front Psychol"},{"issue":"4","key":"10710_CR38","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3102\/1076998606298043","volume":"32","author":"LV Hedges","year":"2007","unstructured":"Hedges LV (2007) Effect sizes in cluster-randomized designs. J Educ Behav Stat 32(4):341\u2013370","journal-title":"J Educ Behav Stat"},{"key":"10710_CR39","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557e60","DOI":"10.1136\/bmj.327.7414.557"},{"key":"10710_CR40","doi-asserted-by":"crossref","unstructured":"Atkins D, Best D, Briss PA et al (2004) GRADE working group. Grading quality of evidence and strength of recommendations. BMJ 328:1490","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"10710_CR41","unstructured":"Ryan R, Hill S (2016) How to GRADE the quality of the evidence. Cochrane Consumers and Communication Group, Version 3.0. available at https:\/\/cccrg.cochrane.org\/author-resources"},{"key":"10710_CR42","doi-asserted-by":"crossref","unstructured":"Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C et al (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomized or non-randomized studies of healthcare interventions, or both. BMJ 358:j4008","DOI":"10.1136\/bmj.j4008"},{"key":"10710_CR43","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic review. BMJ 372","DOI":"10.31222\/osf.io\/v7gm2"},{"issue":"9","key":"10710_CR44","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.1039\/C8FO00888D","volume":"9","author":"A Mafi","year":"2018","unstructured":"Mafi A, Namazi G, Soleimani A, Bahmani F, Aghadavod E, Asemi Z (2018) Metabolic and genetic response to probiotics supplementation in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial. Food Funct 9(9):4763\u20134770","journal-title":"Food Funct"},{"issue":"3","key":"10710_CR45","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2970","volume":"34","author":"S Mohseni","year":"2018","unstructured":"Mohseni S, Bayani M, Bahmani F, Tajabadi-Ebrahimi M, Bayani MA et al (2018) The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double\u2010blind, placebo\u2010controlled trial. Diabetes Metab Res Rev 34(3):e2970","journal-title":"Diabetes Metab Res Rev"},{"key":"10710_CR46","first-page":"1","volume":"21","author":"M Karamali","year":"2018","unstructured":"Karamali M, Eghbalpour S, Rajabi S, Jamilian M, Bahmani F et al (2018) Effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Arch Iran Med 21:1\u20137","journal-title":"Arch Iran Med"},{"key":"10710_CR47","doi-asserted-by":"publisher","first-page":"e0126490","DOI":"10.1371\/journal.pone.0126490","volume":"10","author":"C Zhu","year":"2015","unstructured":"Zhu C, Yang H, Geng Q, Ma Q, Long Y, Zhou C, Chen M (2015) Association of oxidative stress biomarkers with gestational diabetes mellitus in pregnant women: a case-control study. PLoS One 10:e0126490","journal-title":"PLoS One"},{"key":"10710_CR48","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1365-2249.2008.03634.x","volume":"152","author":"LI Filippin","year":"2008","unstructured":"Filippin LI, Vercelio R, Marroni NP, Xavier RM (2008) Redox signaling and inflammatory response in rheumatoid arthritis. Clin Exp Immunol 152:415\u2013422","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10710_CR49","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.18632\/aging.102810","volume":"12","author":"H Deng","year":"2020","unstructured":"Deng H, Dong X, Chen M, Zou Z (2020) Efficacy of probiotics on cognition, and biomarkers of inflammation and oxidative stress in adults with Alzheimer\u2019s disease or mild cognitive impairment \u2014 a meta-analysis of randomized controlled trials. Aging 12(4):4010\u20134039","journal-title":"Aging"},{"key":"10710_CR50","doi-asserted-by":"crossref","unstructured":"Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, Quigley EMM (2010) The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut 59:325e332","DOI":"10.1136\/gut.2008.167270"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10710-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10710-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10710-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:58:30Z","timestamp":1774342710000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10710-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10710"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10710-3","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"1 August 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}