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The capacity of EcN 2.0 to inhibit in vitro the growth of\n                    <jats:italic>E. coli<\/jats:italic>\n                    was demonstrated using strain JJ1886, a representative human clinical ST131 isolate. We evaluated the efficacy of EcN 2.0 in a murine model of stable colonization of the intestinal microbiota by the multidrug-resistant\n                    <jats:italic>E. coli<\/jats:italic>\n                    JJ1886. The administration of EcN 2.0 reduced the individual load of JJ1886 in feces when compared to the placebo-treated animals. Following a 30-day course of daily oral administration of EcN 2.0, 8 of 17 mice no longer excreted the ST131 strain. Furthermore, the results demonstrated that EcN 2.0 was more efficient than EcN WT against clinical multidrug-resistant uropathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    isolates from humans and animals. Accordingly, the probiotic EcN 2.0 may represent a viable strategy to limit the carriage of ST131 and potentially other multidrug-resistant pandemic enterobacterial clones, which in turn could help limit the spread of antimicrobial resistance and the incidence of urinary tract infection.\n                  <\/jats:p>","DOI":"10.1007\/s12602-025-10777-y","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T01:12:33Z","timestamp":1762823553000},"page":"5413-5427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Non-genotoxic Variant of Escherichia coli Nissle 1917 EcN 2.0 Overexpressing Microcins Reduces Intestinal Carriage of ST131 ESBL-Producing Escherichia coli"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-9482","authenticated-orcid":false,"given":"Nicolas","family":"Jousserand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Massiera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Jean","family":"Bordignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Boury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Tremblay-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Dobrindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lavou\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-0081","authenticated-orcid":false,"given":"Eric","family":"Oswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-7986","authenticated-orcid":false,"given":"Delphine","family":"Payros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"10777_CR1","unstructured":"Sobel JD, Brown P. 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