{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:36:52Z","timestamp":1791247012645,"version":"4.1.0"},"reference-count":166,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12602-025-10780-3","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T07:24:20Z","timestamp":1760513060000},"page":"3750-3766","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microbiome-Targeted Probiotic Strategies for the Prevention and Treatment of Osteomyelitis: A Novel Biological Approach"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-4809","authenticated-orcid":false,"given":"Habtemariam Alekaw","family":"Habteweld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abate Wondesen","family":"Tsige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassahun Dires","family":"Ayenew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addisu Alekaw","family":"Habtewold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsegahun Asfaw","family":"Abebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malede Berihun","family":"Yismaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haymanot Berhanu","family":"Taye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"issue":"2","key":"10780_CR1","doi-asserted-by":"publisher","first-page":"e00084","DOI":"10.1128\/CMR.00084-17","volume":"31","author":"N Kavanagh","year":"2018","unstructured":"Kavanagh N, Ryan EJ, Widaa A, Sexton G, Fennell J, O\u2019Rourke S, Cahill KC, Kearney CJ, O\u2019Brien FJ, Kerrigan SW (2018) Staphylococcal osteomyelitis: disease progression, treatment challenges, and future directions. Clin Microbiol Rev 31(2):e00084-17. https:\/\/doi.org\/10.1128\/CMR.00084-17","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"10780_CR2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s11914-019-00548-4","volume":"17","author":"G Muthukrishnan","year":"2019","unstructured":"Muthukrishnan G, Masters EA, Daiss JL, Schwarz EM (2019) Mechanisms of immune evasion and bone tissue colonization that make Staphylococcus aureus the primary pathogen in osteomyelitis. Curr Osteoporos Rep 17(6):395\u2013404. https:\/\/doi.org\/10.1007\/s11914-019-00548-4","journal-title":"Curr Osteoporos Rep"},{"issue":"6","key":"10780_CR3","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.berh.2006.08.014","volume":"20","author":"IG Sia","year":"2006","unstructured":"Sia IG, Berbari EF (2006) Infection and musculoskeletal conditions: osteomyelitis. Best Pract Res Clin Rheumatol. 20(6):1065\u201381. https:\/\/doi.org\/10.1016\/j.berh.2006.08.014","journal-title":"Best Pract Res Clin Rheumatol."},{"key":"10780_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.702484","volume":"8","author":"J Chen","year":"2021","unstructured":"Chen J, Xiong A, Ma Y, Qin C, Ho CL (2021) Impact of the host-microbiome on osteomyelitis pathogenesis. Front Mol Biosci 8:702484. https:\/\/doi.org\/10.3389\/fmolb.2021.702484","journal-title":"Front Mol Biosci"},{"issue":"9","key":"10780_CR5","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1080\/14787210.2017.1372192","volume":"15","author":"CA Ford","year":"2017","unstructured":"Ford CA, Cassat JE (2017) Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis. Expert Rev Anti-Infect Ther 15(9):851\u2013860. https:\/\/doi.org\/10.1080\/14787210.2017.1372192","journal-title":"Expert Rev Anti-Infect Ther"},{"issue":"6","key":"10780_CR6","first-page":"520","volume":"29","author":"S Mahpishanian","year":"2022","unstructured":"Mahpishanian S, Fatemi M, Ghandehari F (2022) The effect of Lactobacillus plantarum and Selenium-enriched Lactobacillus plantarum on Staphylococcus aureus-induced osteomyelitis. J Kerman Univ Med Sci 29(6):520\u20138","journal-title":"J Kerman Univ Med Sci"},{"issue":"4","key":"10780_CR7","doi-asserted-by":"publisher","first-page":"e1007744","DOI":"10.1371\/journal.ppat.1007744","volume":"15","author":"NE Putnam","year":"2019","unstructured":"Putnam NE, Fulbright LE, Curry JM, Ford CA, Petronglo JR, Hendrix AS, Cassat JE (2019) MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis. PLoS Pathog 15(4):e1007744. https:\/\/doi.org\/10.1371\/journal.ppat.1007744","journal-title":"PLoS Pathog"},{"key":"10780_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104431","volume":"148","author":"A Nasser","year":"2020","unstructured":"Nasser A, Azimi T, Ostadmohammadi S, Ostadmohammadi S (2020) A comprehensive review of bacterial osteomyelitis with emphasis on Staphylococcus aureus. Microb Pathog 148:104431. https:\/\/doi.org\/10.1016\/j.micpath.2020.104431","journal-title":"Microb Pathog"},{"issue":"8","key":"10780_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12080516","volume":"12","author":"CE Butrico","year":"2020","unstructured":"Butrico CE, Cassat JE (2020) Quorum sensing and toxin production in Staphylococcus aureus osteomyelitis: pathogenesis and paradox. Toxins (Basel) 12(8):516. https:\/\/doi.org\/10.3390\/toxins12080516","journal-title":"Toxins (Basel)"},{"issue":"10","key":"10780_CR10","doi-asserted-by":"publisher","first-page":"e1008988","DOI":"10.1371\/journal.ppat.1008988","volume":"16","author":"EA Masters","year":"2020","unstructured":"Masters EA, de Mesy Bentley KL, Gill AL, Hao SP, Galloway CA, Salminen AT, Guy DR, McGrath JL, Awad HA, Gill SR, Schwarz EM (2020) Identification of Penicillin binding protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice. PLoS Pathog 16(10):e1008988. https:\/\/doi.org\/10.1371\/journal.ppat.1008988","journal-title":"PLoS Pathog"},{"key":"10780_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2019.102039","volume":"21","author":"EA Masters","year":"2019","unstructured":"Masters EA, Salminen AT, Begolo S, Luke EN, Barrett SC, Overby CT, Gill AL, de Mesy Bentley KL, Awad HA, Gill SR, Schwarz EM, McGrath JL (2019) An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis. Nanomedicine 21:102039. https:\/\/doi.org\/10.1016\/j.nano.2019.102039","journal-title":"Nanomedicine"},{"issue":"5","key":"10780_CR12","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s00223-018-0495-0","volume":"104","author":"K Buch","year":"2019","unstructured":"Buch K, Thuesen ACB, Br\u00f8ns C, Schwarz P (2019) Chronic nonbacterial osteomyelitis: a review. Calcif Tissue Int 104(5):544\u2013553. https:\/\/doi.org\/10.1007\/s00223-018-0495-0","journal-title":"Calcif Tissue Int"},{"issue":"11","key":"10780_CR13","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.3899\/jrheum","volume":"43","author":"SR Hofmann","year":"2016","unstructured":"Hofmann SR, Schnabel A, R\u00f6sen-Wolff A, Morbach H, Girschick HJ, Hedrich CM (2016) Chronic nonbacterial osteomyelitis: pathophysiological concepts and current treatment strategies. J Rheumatol. 43(11):1956\u20131964. https:\/\/doi.org\/10.3899\/jrheum","journal-title":"J Rheumatol."},{"key":"10780_CR14","doi-asserted-by":"crossref","unstructured":"Zimmerli W (2021) Osteomyelitis: classification. Bone and joint infections: from microbiology to diagnostics and treatment. 265-72","DOI":"10.1002\/9781119720676.ch16"},{"issue":"1","key":"10780_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/1471-2474-14-187","volume":"14","author":"CJ Sanchez Jr","year":"2013","unstructured":"Sanchez CJ Jr, Ward CL, Romano DR, Hurtgen BJ, Hardy SK, Woodbury RL, Trevino AV, Rathbone CR, Wenke JC (2013) Staphylococcus aureus biofilms decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro. BMC Musculoskelet Disord 14(1):187. https:\/\/doi.org\/10.1186\/1471-2474-14-187","journal-title":"BMC Musculoskelet Disord"},{"key":"10780_CR16","doi-asserted-by":"publisher","first-page":"936285","DOI":"10.3389\/fmicb.2022.936285","volume":"13","author":"S Wu","year":"2022","unstructured":"Wu S, Wu B, Liu Y, Deng S, Lei L, Zhang H (2022) Mini review therapeutic strategies targeting for biofilm and bone infections. Front Microbiol 13:936285. https:\/\/doi.org\/10.3389\/fmicb.2022.936285","journal-title":"Front Microbiol"},{"issue":"2","key":"10780_CR17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3382\/ps\/pev320","volume":"95","author":"RF Wideman","year":"2016","unstructured":"Wideman RF (2016) Bacterial chondronecrosis with osteomyelitis and lameness in broilers: a review. Poult Sci 95(2):325\u201344. https:\/\/doi.org\/10.3382\/ps\/pev320","journal-title":"Poult Sci"},{"issue":"7","key":"10780_CR18","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1007\/s11999-009-0857-z","volume":"467","author":"J Parvizi","year":"2009","unstructured":"Parvizi J, Azzam K, Ghanem E, Austin MS, Rothman RH (2009) Periprosthetic infection due to resistant staphylococci: serious problems on the horizon. Clin Orthop Relat Res 467(7):1732\u20139. https:\/\/doi.org\/10.1007\/s11999-009-0857-z","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"10780_CR19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4103\/0974-777X.68535","volume":"2","author":"PS Loomba","year":"2010","unstructured":"Loomba PS, Taneja J, Mishra B (2010) Methicillin and vancomycin resistant S. aureus in hospitalized patients. J Glob Infect Dis 2(3):275\u201383. https:\/\/doi.org\/10.4103\/0974-777X.68535","journal-title":"J Glob Infect Dis"},{"issue":"27","key":"10780_CR20","doi-asserted-by":"publisher","first-page":"196","DOI":"10.22203\/ecm.v027a15","volume":"25","author":"W Reizner","year":"2014","unstructured":"Reizner W, Hunter JG, O\u2019Malley NT, Southgate RD, Schwarz EM, Kates SL (2014) A systematic review of animal models for Staphylococcus aureus osteomyelitis. Eur Cell Mater. 25(27):196\u2013212. https:\/\/doi.org\/10.22203\/ecm.v027a15","journal-title":"Eur Cell Mater."},{"key":"10780_CR21","unstructured":"Nelson RE, Hyun D, Jezek A, Samore MH. Mortality, length of stay, and healthcare costs associated with multidrug-resistant bacterial infections among elderly hospitalized patients in the United States"},{"issue":"1","key":"10780_CR22","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3390\/microorganisms11010182","volume":"11","author":"HJ Lee","year":"2023","unstructured":"Lee HJ, Lee JB, Park SY, Choi IS, Lee SW (2023) Antimicrobial activity of Ligilactobacillus animalis SWLA-1 and its cell-free supernatant against multidrug-resistant bacteria and its potential use as an alternative to antimicrobial agents. Microorganisms 11(1):182. https:\/\/doi.org\/10.3390\/microorganisms11010182","journal-title":"Microorganisms"},{"issue":"9","key":"10780_CR23","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3390\/antibiotics12091444","volume":"12","author":"SY Park","year":"2023","unstructured":"Park SY, Lee HJ, Kim HS, Kim DH, Lee SW, Yoon HY (2023) Anti-staphylococcal activity of Ligilactobacillus animalis SWLA-1 and its supernatant against multidrug-resistant Staphylococcus pseudintermedius in novel rat model of acute osteomyelitis. Antibiotics 12(9):1444. https:\/\/doi.org\/10.3390\/antibiotics12091444","journal-title":"Antibiotics"},{"key":"10780_CR24","unstructured":"dos Santos TR. Novel therapeutic strategies for the management of diabetic foot infections: the evaluation of selected antimicrobial peptides against clinically isolated bacterial pathogens (Doctoral dissertation, Universidade de Lisboa (Portugal))"},{"issue":"1","key":"10780_CR25","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12934-021-01592-5","volume":"20","author":"F Zhang","year":"2021","unstructured":"Zhang F, Wang B, Liu S, Chen Y, Lin Y, Liu Z, Zhang X, Yu B (2021) Bacillus subtilis revives conventional antibiotics against Staphylococcus aureus osteomyelitis. Microb Cell Fact 20(1):102. https:\/\/doi.org\/10.1186\/s12934-021-01592-5","journal-title":"Microb Cell Fact"},{"issue":"6","key":"10780_CR26","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1136\/gut.52.6.827","volume":"52","author":"DR Mack","year":"2003","unstructured":"Mack DR, Ahrne S, Hyde L, Wei S, Hollingsworth MA (2003) Extracellular MUC3 mucin secretion follows the adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut 52(6):827\u201333. https:\/\/doi.org\/10.1136\/gut.52.6.827","journal-title":"Gut"},{"issue":"1","key":"10780_CR27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00284-020-02247-1","volume":"78","author":"F Kalayc\u0131 Y\u00fcksek","year":"2021","unstructured":"Kalayc\u0131 Y\u00fcksek F, G\u00fcm\u00fc\u015f D, G\u00fcndo\u011fan G\u0130, An\u011f K\u00fc\u00e7\u00fcker M (2021) Cell-free Lactobacillus sp supernatants modulate Staphylococcus aureus growth, adhesion and invasion to human osteoblast (HOB) cells. Curr Microbiol 78(1):125\u2013132. https:\/\/doi.org\/10.1007\/s00284-020-02247-1","journal-title":"Curr Microbiol"},{"issue":"18","key":"10780_CR28","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1073\/pnas.0700440104","volume":"104","author":"SC Corr","year":"2007","unstructured":"Corr SC, Li Y, Riedel CU, O\u2019Toole PW, Hill C, Gahan CG (2007) Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proc Natl Acad Sci U S A 104(18):7617\u201321. https:\/\/doi.org\/10.1073\/pnas.0700440104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10780_CR29","doi-asserted-by":"publisher","first-page":"421","DOI":"10.4141\/A05-049","volume":"85","author":"JD Richards","year":"2005","unstructured":"Richards JD, Gong J, De Lange CF (2005) The gastrointestinal microbiota and its role in monogastric nutrition and health with an emphasis on pigs: current understanding, possible modulations, and new technologies for ecological studies. Can J Anim Sci 85(4):421\u201335","journal-title":"Can J Anim Sci"},{"issue":"1","key":"10780_CR30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12602-020-09673-4","volume":"13","author":"A Algburi","year":"2021","unstructured":"Algburi A, Al-Hasani HM, Ismael TK, Abdelhameed A, Weeks R, Ermakov AM, Chikindas ML (2021) Antimicrobial activity of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 against Staphylococcus aureus biofilms isolated from wound infection. Probiotics Antimicrob Proteins 13(1):125\u2013134. https:\/\/doi.org\/10.1007\/s12602-020-09673-4","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10780_CR31","unstructured":"Niers LE. Probiotic bacteria for prevention of atopic diseases: design and application (Doctoral dissertation, University Utrecht)"},{"issue":"5","key":"10780_CR32","doi-asserted-by":"publisher","first-page":"e64416","DOI":"10.1371\/journal.pone.0064416","volume":"8","author":"I von Ossowski","year":"2013","unstructured":"von Ossowski I, Pietil\u00e4 TE, Rintahaka J, Nummenmaa E, M\u00e4kinen VM, Reunanen J, Satokari R, de Vos WM, Palva I, Palva A (2013) Using recombinant lactococci as an approach to dissect the immunomodulating capacity of surface piliation in probiotic Lactobacillus rhamnosus GG. PLoS One 8(5):e64416. https:\/\/doi.org\/10.1371\/journal.pone.0064416","journal-title":"PLoS One"},{"key":"10780_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101444","volume":"30","author":"J Su","year":"2025","unstructured":"Su J, Wu Y, Wang Z, Zhang D, Yang X, Zhao Y, Yu A (2025) Probiotic biofilm modified scaffolds for facilitating osteomyelitis treatment through sustained release of bacteriophage and regulated macrophage polarization. Mater Today Bio 30:101444. https:\/\/doi.org\/10.1016\/j.mtbio.2025.101444","journal-title":"Mater Today Bio"},{"key":"10780_CR34","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.bioactmat.2025.01.003","volume":"46","author":"FS Fu","year":"2025","unstructured":"Fu FS, Chen HH, Chen Y, Yuan Y, Zhao Y, Yu A, Zhang XZ (2025) Engineered Bacillus subtilis enhances bone regeneration via immunoregulation and anti-infection. Bioact Mater 46:503\u2013515. https:\/\/doi.org\/10.1016\/j.bioactmat.2025.01.003","journal-title":"Bioact Mater"},{"key":"10780_CR35","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-024-10441-x","author":"C Park","year":"2024","unstructured":"Park C, Park OJ, Kwon Y, Lee J, Yun CH, Han SH (2024) Differential regulatory effects of probiotics on bone metabolism by the status of bone health and delivery route. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10441-x","journal-title":"Probiotics Antimicrob Proteins."},{"issue":"6","key":"10780_CR36","doi-asserted-by":"publisher","first-page":"G807","DOI":"10.1152\/ajpgi.00243.2009","volume":"298","author":"CL Ohland","year":"2010","unstructured":"Ohland CL, Macnaughton WK (2010) Probiotic bacteria and intestinal epithelial barrier function. Am J Physiol Gastrointest Liver Physiol. 298(6):G807-19. https:\/\/doi.org\/10.1152\/ajpgi.00243.2009","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"10780_CR37","unstructured":"Chen J, Wedekind KJ, Dibner JJ, Richards JD. Effects of nutrition and gut barrier function on the development of osteomyelitis complex and other forms of lameness in poultry"},{"issue":"1","key":"10780_CR38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3382\/ps\/peu025","volume":"94","author":"RF Wideman Jr","year":"2015","unstructured":"Wideman RF Jr, Al-Rubaye A, Kwon YM, Blankenship J, Lester H, Mitchell KN, Pevzner IY, Lohrmann T, Schleifer J (2015) Prophylactic administration of a combined prebiotic and probiotic, or therapeutic administration of enrofloxacin, to reduce the incidence of bacterial chondronecrosis with osteomyelitis in broilers. Poult Sci 94(1):25\u201336. https:\/\/doi.org\/10.3382\/ps\/peu025","journal-title":"Poult Sci"},{"key":"10780_CR39","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_156_21","volume":"12","author":"N Saidi","year":"2023","unstructured":"Saidi N, Saderi H, Owlia P, Soleimani M (2023) Anti-biofilm potential of Lactobacillus casei and Lactobacillus rhamnosus cell-free supernatant extracts against Staphylococcus aureus. Adv Biomed Res 12:50. https:\/\/doi.org\/10.4103\/abr.abr_156_21","journal-title":"Adv Biomed Res"},{"issue":"4","key":"10780_CR40","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1556\/1886.2018.00022","volume":"8","author":"H Frickmann","year":"2018","unstructured":"Frickmann H, Klenk C, Warnke P, Redanz S, Podbielski A (2018) Influence of probiotic culture supernatants on in vitro biofilm formation of Staphylococci. Eur J Microbiol Immunol (Bp) 8(4):119\u2013127. https:\/\/doi.org\/10.1556\/1886.2018.00022","journal-title":"Eur J Microbiol Immunol (Bp)"},{"issue":"3","key":"10780_CR41","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.3168\/jds.2021-21126","volume":"105","author":"YH Jiang","year":"2022","unstructured":"Jiang YH, Xin WG, Yang LY, Ying JP, Zhao ZS, Lin LB, Li XZ, Zhang QL (2022) A novel bacteriocin against Staphylococcus aureus from Lactobacillus paracasei isolated from Yunnan traditional fermented yogurt: purification, antibacterial characterization, and antibiofilm activity. J Dairy Sci 105(3):2094\u20132107. https:\/\/doi.org\/10.3168\/jds.2021-21126","journal-title":"J Dairy Sci"},{"issue":"1","key":"10780_CR42","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12602-018-9505-9","volume":"12","author":"JS Ong","year":"2020","unstructured":"Ong JS, Taylor TD, Yong CC, Khoo BY, Sasidharan S, Choi SB, Ohno H, Liong MT (2020) Lactobacillus plantarum USM8613 aids in wound healing and suppresses Staphylococcus aureus infection at wound sites. Probiotics Antimicrob Proteins 12(1):125\u2013137. https:\/\/doi.org\/10.1007\/s12602-018-9505-9","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"2","key":"10780_CR43","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1017\/S0266462312000086","volume":"28","author":"A Morrison","year":"2012","unstructured":"Morrison A, Polisena J, Husereau D, Moulton K, Clark M, Fiander M et al (2012) The effect of English-language restriction on systematic review-based meta-analyses: a systematic review of empirical studies. Int J Technol Assess Health Care 28(2):138\u201344","journal-title":"Int J Technol Assess Health Care"},{"issue":"11","key":"10780_CR44","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.2337\/db20-0503","volume":"69","author":"M Zou","year":"2020","unstructured":"Zou M, Cai Y, Hu P, Cao Y, Luo X, Fan X, Zhang B, Wu X, Jiang N, Lin Q, Zhou H, Xue Y, Gao F (2020) Analysis of the composition and functions of the microbiome in diabetic foot osteomyelitis based on 16S rRNA and metagenome sequencing technology. Diabetes 69(11):2423\u20132439. https:\/\/doi.org\/10.2337\/db20-0503","journal-title":"Diabetes"},{"key":"10780_CR45","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fcimb.2018.00282","volume":"8","author":"J Jneid","year":"2018","unstructured":"Jneid J, Cassir N, Schuldiner S, Jourdan N, Sotto A, Lavigne JP, La Scola B (2018) Exploring the microbiota of diabetic foot infections with culturomics. Front Cell Infect Microbiol 8:282. https:\/\/doi.org\/10.3389\/fcimb.2018.00282","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10780_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042375","volume":"23","author":"BK Patel","year":"2022","unstructured":"Patel BK, Patel KH, Huang RY, Lee CN, Moochhala SM (2022) The gut-skin microbiota axis and its role in diabetic wound healing-a review based on current literature. Int J Mol Sci 23(4):2375. https:\/\/doi.org\/10.3390\/ijms23042375","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10780_CR47","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.cmi.2018.04.036","volume":"25","author":"K Johani","year":"2019","unstructured":"Johani K, Fritz BG, Bjarnsholt T, Lipsky BA, Jensen SO, Yang M, Dean A, Hu H, Vickery K, Malone M (2019) Understanding the microbiome of diabetic foot osteomyelitis: insights from molecular and microscopic approaches. Clin Microbiol Infect 25(3):332\u2013339. https:\/\/doi.org\/10.1016\/j.cmi.2018.04.036","journal-title":"Clin Microbiol Infect"},{"issue":"10","key":"10780_CR48","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.7860\/JCDR\/2013\/5628.3531","volume":"7","author":"SK Padhiary","year":"2013","unstructured":"Padhiary SK, Srivastava G, Panda S, Subudhi S, Lenka SE (2013) E. coli associated extensive bilateral maxillary osteomyelitis: a rare case report. J Clin Diagn Res 7(10):2380\u20132. https:\/\/doi.org\/10.7860\/JCDR\/2013\/5628.3531","journal-title":"J Clin Diagn Res"},{"issue":"4","key":"10780_CR49","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1590\/S1517-838220100004000025","volume":"41","author":"E Gaetti-Jardim J\u00fanior","year":"2010","unstructured":"Gaetti-Jardim J\u00fanior E, Fardin AC, Gaetti-Jardim EC, de Castro AL, Schweitzer CM, Avila-Campos MJ (2010) Microbiota associated with chronic osteomyelitis of the jaws. Braz J Microbiol 41(4):1056\u201364. https:\/\/doi.org\/10.1590\/S1517-838220100004000025","journal-title":"Braz J Microbiol"},{"key":"10780_CR50","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/689240","volume":"2015","author":"A Gannepalli","year":"2015","unstructured":"Gannepalli A, Ayinampudi BK, Baghirath PV, Reddy GV (2015) Actinomycotic osteomyelitis of maxilla presenting as oroantral fistula: a rare case report. Case Rep Dent 2015:689240. https:\/\/doi.org\/10.1155\/2015\/689240","journal-title":"Case Rep Dent"},{"key":"10780_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.humic.2017.09.002","author":"J Jneid","year":"2017","unstructured":"Jneid J, Lavigne JP, Scola BL, Cassir N (2017) The diabetic foot microbiota: a review. Hum Microbiome J. https:\/\/doi.org\/10.1016\/j.humic.2017.09.002","journal-title":"Hum Microbiome J"},{"key":"10780_CR52","doi-asserted-by":"publisher","first-page":"115568","DOI":"10.1016\/j.bone.2020.115568","volume":"141","author":"KD Alder","year":"2020","unstructured":"Alder KD, Lee I, Munger AM, Kwon HK, Morris MT, Cahill SV, Back J, Yu KE, Lee FY (2020) Intracellular Staphylococcus aureus in bone and joint infections: a mechanism of disease recurrence, inflammation, and bone and cartilage destruction. Bone 141:115568. https:\/\/doi.org\/10.1016\/j.bone.2020.115568","journal-title":"Bone"},{"issue":"7","key":"10780_CR53","doi-asserted-by":"publisher","first-page":"e00932","DOI":"10.1128\/IAI.00932-19","volume":"88","author":"KL Urish","year":"2020","unstructured":"Urish KL, Cassat JE (2020) Staphylococcus aureus osteomyelitis: bone, bugs, and surgery. Infect Immun 88(7):e00932-19. https:\/\/doi.org\/10.1128\/IAI.00932-19","journal-title":"Infect Immun"},{"issue":"4702","key":"10780_CR54","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1126\/science.4001933","volume":"24","author":"AG Gristina","year":"1985","unstructured":"Gristina AG, Oga M, Webb LX, Hobgood CD (1985) Adherent bacterial colonization in the pathogenesis of osteomyelitis. Science 24(4702):990\u20133. https:\/\/doi.org\/10.1126\/science.4001933","journal-title":"Science"},{"issue":"6","key":"10780_CR55","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3109\/17453674.2010.537810","volume":"81","author":"J Esteban","year":"2010","unstructured":"Esteban J, Molina-Manso D, Spiliopoulou I, Cordero-Ampuero J, Fern\u00e1ndez-Roblas R, Foka A, G\u00f3mez-Barrena E (2010) Biofilm development by clinical isolates of Staphylococcus spp. from retrieved orthopedic prostheses. Acta Orthop 81(6):674\u20139. https:\/\/doi.org\/10.3109\/17453674.2010.537810","journal-title":"Acta Orthop"},{"issue":"9","key":"10780_CR56","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1002\/jbmr.2887","volume":"31","author":"CJ Hernandez","year":"2016","unstructured":"Hernandez CJ, Guss JD, Luna M, Goldring SR (2016) Links between the microbiome and bone. J Bone Miner Res 31(9):1638\u201346. https:\/\/doi.org\/10.1002\/jbmr.2887","journal-title":"J Bone Miner Res"},{"issue":"96","key":"10780_CR57","first-page":"1","volume":"3","author":"C Medina-Gomez","year":"2018","unstructured":"Medina-Gomez C (2018) Bone and the gut microbiome: a new dimension. J Lab Precis Med 3(96):1\u20130","journal-title":"J Lab Precis Med"},{"issue":"4","key":"10780_CR58","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1080\/19490976.2016.1182289","volume":"7","author":"FC Phillips","year":"2016","unstructured":"Phillips FC, Gurung P, Kanneganti TD (2016) Microbiota and caspase-1\/caspase-8 regulate IL-1\u03b2-mediated bone disease. Gut Microbes 7(4):334\u2013341. https:\/\/doi.org\/10.1080\/19490976.2016.1182289","journal-title":"Gut Microbes"},{"issue":"4","key":"10780_CR59","doi-asserted-by":"publisher","first-page":"e0122390","DOI":"10.1371\/journal.pone.0122390","volume":"10","author":"G Tellez","year":"2015","unstructured":"Tellez G, Latorre JD, Kuttappan VA, Hargis BM, Hernandez-Velasco X (2015) Rye affects bacterial translocation, intestinal viscosity, microbiota composition and bone mineralization in Turkey poults. PLoS One 10(4):e0122390. https:\/\/doi.org\/10.1371\/journal.pone.0122390","journal-title":"PLoS One"},{"issue":"5","key":"10780_CR60","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1111\/trf.13477","volume":"56","author":"S Pa\u00efss\u00e9","year":"2016","unstructured":"Pa\u00efss\u00e9 S, Valle C, Servant F, Courtney M, Burcelin R, Amar J, Lelouvier B (2016) Comprehensive description of blood microbiome from healthy donors assessed by 16S targeted metagenomic sequencing. Transfusion 56(5):1138\u201347. https:\/\/doi.org\/10.1111\/trf.13477","journal-title":"Transfusion"},{"issue":"4","key":"10780_CR61","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/femsre\/fuv013","volume":"39","author":"M Potgieter","year":"2015","unstructured":"Potgieter M, Bester J, Kell DB, Pretorius E (2015) The dormant blood microbiome in chronic, inflammatory diseases. FEMS Microbiol Rev 39(4):567\u201391. https:\/\/doi.org\/10.1093\/femsre\/fuv013","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"10780_CR62","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3389\/fendo.2012.00183","volume":"22","author":"RF Wideman","year":"2013","unstructured":"Wideman RF, Prisby RD (2013) Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis. Front Endocrinol (Lausanne). 22(3):183. https:\/\/doi.org\/10.3389\/fendo.2012.00183","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"5","key":"10780_CR63","doi-asserted-by":"publisher","first-page":"406","DOI":"10.4236\/aim.2018.85027","volume":"8","author":"S Panaiotov","year":"2018","unstructured":"Panaiotov S, Filevski G, Equestre M, Nikolova E, Kalfin R (2018) Cultural isolation and characteristics of the blood microbiome of healthy individuals. Adv Microbiol 8(5):406\u201321","journal-title":"Adv Microbiol"},{"issue":"6","key":"10780_CR64","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1017\/S1751731116002433","volume":"11","author":"E Paludo","year":"2017","unstructured":"Paludo E, Ibelli AMG, Peixoto JO, Tavernari FC, Lima-Rosa CAV, Pandolfi JRC, Ledur MC (2017) The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers. Animal 11(6):1063\u20131070. https:\/\/doi.org\/10.1017\/S1751731116002433","journal-title":"Animal"},{"issue":"1","key":"10780_CR65","doi-asserted-by":"publisher","first-page":"25882","DOI":"10.1038\/srep25882","volume":"6","author":"RK Mandal","year":"2016","unstructured":"Mandal RK, Jiang T, Al-Rubaye AA, Rhoads DD, Wideman RF, Zhao J, Pevzner I, Kwon YM (2016) An investigation into blood microbiota and its potential association with bacterial chondronecrosis with osteomyelitis (BCO) in broilers. Sci Rep 6(1):25882. https:\/\/doi.org\/10.1038\/srep25882","journal-title":"Sci Rep"},{"issue":"2","key":"10780_CR66","doi-asserted-by":"publisher","first-page":"e0017022","DOI":"10.1128\/spectrum.00170-22","volume":"10","author":"TI Bui","year":"2022","unstructured":"Bui TI, Gill AL, Mooney RA, Gill SR (2022) Modulation of gut microbiota metabolism in obesity-related type 2 diabetes reduces osteomyelitis severity. Microbiol Spectr 10(2):e0017022. https:\/\/doi.org\/10.1128\/spectrum.00170-22","journal-title":"Microbiol Spectr"},{"issue":"1","key":"10780_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02711-8","volume":"24","author":"P Rausch","year":"2022","unstructured":"Rausch P, Hartmann M, Baines JF, von Bismarck P (2022) Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis. Arthritis Res Ther 24(1):54. https:\/\/doi.org\/10.1186\/s13075-021-02711-8","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10780_CR68","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00393-021-01035-x","volume":"82","author":"M Zeus","year":"2023","unstructured":"Zeus M, Janssen S, Laws HJ, Fischer U, Borkhardt A, Oommen PT (2023) Results from a\u00a0pilot study on the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis. Z Rheumatol 82(2):123\u2013133. https:\/\/doi.org\/10.1007\/s00393-021-01035-x","journal-title":"Z Rheumatol"},{"issue":"1","key":"10780_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-11-47","volume":"11","author":"CM Hedrich","year":"2013","unstructured":"Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ (2013) Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J 11(1):47. https:\/\/doi.org\/10.1186\/1546-0096-11-47","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"10780_CR70","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bone.2005.07.009","volume":"38","author":"PJ Ferguson","year":"2006","unstructured":"Ferguson PJ, Bing X, Vasef MA, Ochoa LA, Mahgoub A, Waldschmidt TJ, Tygrett LT, Schlueter AJ, El-Shanti H (2006) A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis. Bone 38(1):41\u20137. https:\/\/doi.org\/10.1016\/j.bone.2005.07.009","journal-title":"Bone"},{"key":"10780_CR71","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.clim.2018.04.011","volume":"196","author":"D Brandt","year":"2018","unstructured":"Brandt D, Sohr E, Pablik J, Schnabel A, Kapplusch F, M\u00e4bert K, Girschick JH, Morbach H, Thielemann F, Hofmann SR, Hedrich CM (2018) CD14+ monocytes contribute to inflammation in chronic nonbacterial osteomyelitis (CNO) through increased NLRP3 inflammasome expression. Clin Immunol 196:77\u201384. https:\/\/doi.org\/10.1016\/j.clim.2018.04.011","journal-title":"Clin Immunol"},{"issue":"11","key":"10780_CR72","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1093\/jbmr\/zjae141","volume":"39","author":"E Roberts","year":"2024","unstructured":"Roberts E, Charras A, Hahn G, Hedrich CM (2024) An improved understanding of pediatric chronic nonbacterial osteomyelitis pathophysiology informs current and future treatment. J Bone Miner Res 39(11):1523\u20131538. https:\/\/doi.org\/10.1093\/jbmr\/zjae141","journal-title":"J Bone Miner Res"},{"issue":"2","key":"10780_CR73","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.clim.2015.09.013","volume":"161","author":"SR Hofmann","year":"2015","unstructured":"Hofmann SR, Kubasch AS, Ioannidis C, R\u00f6sen-Wolff A, Girschick HJ, Morbach H, Hedrich CM (2015) Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1\u03b2 expression and release. Clin Immunol 161(2):300\u20137. https:\/\/doi.org\/10.1016\/j.clim.2015.09.013","journal-title":"Clin Immunol"},{"issue":"1","key":"10780_CR74","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jbspin.2018.02.008","volume":"86","author":"L Ib\u00e1\u00f1ez","year":"2019","unstructured":"Ib\u00e1\u00f1ez L, Rouleau M, Wakkach A, Blin-Wakkach C (2019) Gut microbiome and bone. Joint Bone Spine 86(1):43\u201347. https:\/\/doi.org\/10.1016\/j.jbspin.2018.02.008","journal-title":"Joint Bone Spine"},{"issue":"11","key":"10780_CR75","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1074\/jbc.H120.012867","volume":"295","author":"EL Hartland","year":"2020","unstructured":"Hartland EL (2020) A potential new target for autoinflammatory bone disease. J Biol Chem 295(11):3401\u20133402. https:\/\/doi.org\/10.1074\/jbc.H120.012867","journal-title":"J Biol Chem"},{"issue":"3","key":"10780_CR76","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1073\/pnas.1318688111","volume":"111","author":"JR Lukens","year":"2014","unstructured":"Lukens JR, Gross JM, Calabrese C, Iwakura Y, Lamkanfi M, Vogel P, Kanneganti TD (2014) Critical role for inflammasome-independent IL-1\u03b2 production in osteomyelitis. Proc Natl Acad Sci U S A 111(3):1066\u201371. https:\/\/doi.org\/10.1073\/pnas.1318688111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10780_CR77","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jcp.24340","volume":"228","author":"LR McCabe","year":"2013","unstructured":"McCabe LR, Irwin R, Schaefer L, Britton RA (2013) Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol 228(8):1793\u20138","journal-title":"J Cell Physiol"},{"issue":"8","key":"10780_CR78","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1097\/MIB.0b013e318289e17b","volume":"19","author":"R Irwin","year":"2013","unstructured":"Irwin R, Lee T, Young VB, Parameswaran N, McCabe LR (2013) Colitis-induced bone loss is gender dependent and associated with increased inflammation. Inflamm Bowel Dis 19(8):1586\u201397","journal-title":"Inflamm Bowel Dis"},{"key":"10780_CR79","doi-asserted-by":"publisher","first-page":"1342172","DOI":"10.3389\/fmicb.2024.1342172","volume":"15","author":"R Xu","year":"2024","unstructured":"Xu R, Li S, Zhang Y, Pu Y, Luo G, Wang X (2024) Causal effects of gut microbiota on the risk of osteomyelitis: a Mendelian randomization study. Front Microbiol 15:1342172. https:\/\/doi.org\/10.3389\/fmicb.2024.1342172","journal-title":"Front Microbiol"},{"key":"10780_CR80","doi-asserted-by":"publisher","first-page":"1338989","DOI":"10.3389\/fcimb.2024.1338989","volume":"14","author":"W Zeng","year":"2024","unstructured":"Zeng W, Wu Y, Liang X, Cun D, Ma L, Zhang J, Huang F, Jiang Z (2024) Causal associations between human gut microbiota and osteomyelitis: a Mendelian randomization study. Front Cell Infect Microbiol 14:1338989. https:\/\/doi.org\/10.3389\/fcimb.2024.1338989","journal-title":"Front Cell Infect Microbiol"},{"issue":"46","key":"10780_CR81","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba5723","volume":"6","author":"L Tan","year":"2020","unstructured":"Tan L, Fu J, Feng F, Liu X, Cui Z, Li B, Han Y, Zheng Y, Yeung KWK, Li Z, Zhu S, Liang Y, Feng X, Wang X, Wu S (2020) Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection. Sci Adv 6(46):eaba5723. https:\/\/doi.org\/10.1126\/sciadv.aba5723","journal-title":"Sci Adv"},{"issue":"16","key":"10780_CR82","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.2147\/IDR.S413416","volume":"23","author":"HA Habteweld","year":"2023","unstructured":"Habteweld HA, Asfaw T (2023) Novel dietary approach with probiotics, prebiotics, and synbiotics to mitigate antimicrobial resistance and subsequent out marketplace of antimicrobial agents: a review. Infect Drug Resist 23(16):3191\u20133211. https:\/\/doi.org\/10.2147\/IDR.S413416","journal-title":"Infect Drug Resist"},{"issue":"30","key":"10780_CR83","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1074\/jbc.M114.610733","volume":"290","author":"J Miyamoto","year":"2015","unstructured":"Miyamoto J, Mizukure T, Park SB, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, Tanabe S (2015) A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway. J Biol Chem 290(30):2902\u201318. https:\/\/doi.org\/10.1074\/jbc.M114.610733","journal-title":"J Biol Chem"},{"issue":"5","key":"10780_CR84","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3945\/jn.110.135657","volume":"141","author":"D Ulluwishewa","year":"2011","unstructured":"Ulluwishewa D, Anderson RC, McNabb WC, Moughan PJ, Wells JM, Roy NC (2011) Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 141(5):769\u201376. https:\/\/doi.org\/10.3945\/jn.110.135657","journal-title":"J Nutr."},{"key":"10780_CR85","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3389\/fimmu.2013.00280","volume":"4","author":"L Pastorelli","year":"2013","unstructured":"Pastorelli L, De Salvo C, Mercado JR, Vecchi M, Pizarro TT (2013) Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front Immunol 4:280. https:\/\/doi.org\/10.3389\/fimmu.2013.00280","journal-title":"Front Immunol"},{"issue":"1","key":"10780_CR86","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/00071668.2013.865834","volume":"55","author":"GR Murugesan","year":"2014","unstructured":"Murugesan GR, Gabler NK, Persia ME (2014) Effects of direct-fed microbial supplementation on broiler performance, intestinal nutrient transport and integrity under experimental conditions with increased microbial challenge. Br Poult Sci 55(1):89\u201397. https:\/\/doi.org\/10.1080\/00071668.2013.865834","journal-title":"Br Poult Sci"},{"issue":"7","key":"10780_CR87","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1007\/s00383-002-0855-7","volume":"18","author":"AF Mattar","year":"2002","unstructured":"Mattar AF, Teitelbaum DH, Drongowski RA, Yongyi F, Harmon CM, Coran AG (2002) Probiotics upregulate MUC-2 mucin gene expression in a Caco-2 cell-culture model. Pediatr Surg Int. 18(7):586\u201390. https:\/\/doi.org\/10.1007\/s00383-002-0855-7","journal-title":"Pediatr Surg Int."},{"issue":"5","key":"10780_CR88","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/s41591-019-0439-x","volume":"25","author":"J Suez","year":"2019","unstructured":"Suez J, Zmora N, Segal E, Elinav E (2019) The pros, cons, and many unknowns of probiotics. Nat Med 25(5):716\u2013729. https:\/\/doi.org\/10.1038\/s41591-019-0439-x","journal-title":"Nat Med"},{"issue":"4","key":"10780_CR89","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1002\/jbmr.3635","volume":"34","author":"JD Schepper","year":"2019","unstructured":"Schepper JD, Collins FL, Rios-Arce ND, Raehtz S, Schaefer L, Gardinier JD, Britton RA, Parameswaran N, McCabe LR (2019) Probiotic Lactobacillus reuteri prevents postantibiotic bone loss by reducing intestinal dysbiosis and preventing barrier disruption. J Bone Miner Res 34(4):681\u2013698. https:\/\/doi.org\/10.1002\/jbmr.3635","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10780_CR90","doi-asserted-by":"publisher","first-page":"870","DOI":"10.3382\/ps.2011-01907","volume":"91","author":"RF Wideman","year":"2012","unstructured":"Wideman RF, Hamal KR, Stark JM, Blankenship J, Lester H, Mitchell KN, Lorenzoni G, Pevzner I (2012) A wire-flooring model for inducing lameness in broilers: evaluation of probiotics as a prophylactic treatment. Poult Sci 91(4):870\u201383. https:\/\/doi.org\/10.3382\/ps.2011-01907","journal-title":"Poult Sci"},{"issue":"9","key":"10780_CR91","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.3382\/ps.2013-03150","volume":"92","author":"RF Wideman Jr","year":"2013","unstructured":"Wideman RF Jr, Al-Rubaye A, Gilley A, Reynolds D, Lester H, Yoho D, Hughes JM, Pevzner I (2013) Susceptibility of 4 commercial broiler crosses to lameness attributable to bacterial chondronecrosis with osteomyelitis. Poult Sci 92(9):2311\u201325. https:\/\/doi.org\/10.3382\/ps.2013-03150","journal-title":"Poult Sci"},{"issue":"5","key":"10780_CR92","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s12223-010-0082-x","volume":"55","author":"B Sadowska","year":"2010","unstructured":"Sadowska B, Walencka E, Wieckowska-Szakiel M, R\u00f3\u017calska B (2010) Bacteria competing with the adhesion and biofilm formation by Staphylococcus aureus. Folia Microbiol (Praha) 55(5):497\u2013501. https:\/\/doi.org\/10.1007\/s12223-010-0082-x","journal-title":"Folia Microbiol (Praha)"},{"issue":"1","key":"10780_CR93","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s12223-008-0009-y","volume":"53","author":"E Walencka","year":"2008","unstructured":"Walencka E, R\u00f3zalska S, Sadowska B, R\u00f3zalska B (2008) The influence of Lactobacillus acidophilus-derived surfactants on staphylococcal adhesion and biofilm formation. Folia Microbiol (Praha). 53(1):61\u20136. https:\/\/doi.org\/10.1007\/s12223-008-0009-y","journal-title":"Folia Microbiol (Praha)."},{"issue":"3","key":"10780_CR94","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000328512","volume":"20","author":"P Varma","year":"2011","unstructured":"Varma P, Nisha N, Dinesh KR, Kumar AV, Biswas R (2011) Anti-infective properties of Lactobacillus fermentum against Staphylococcus aureus and Pseudomonas aeruginosa. J Mol Microbiol Biotechnol 20(3):137\u201343. https:\/\/doi.org\/10.1159\/000328512","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"5","key":"10780_CR95","doi-asserted-by":"publisher","first-page":"854e","DOI":"10.1097\/PRS.0b013e3182a3c11e","volume":"132","author":"VW Wong","year":"2013","unstructured":"Wong VW, Martindale RG, Longaker MT, Gurtner GC (2013) From germ theory to germ therapy: skin microbiota, chronic wounds, and probiotics. Plast Reconstr Surg 132(5):854e\u2013861e. https:\/\/doi.org\/10.1097\/PRS.0b013e3182a3c11e","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"10780_CR96","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1469-0691.2005.01142.x","volume":"11","author":"JC Vald\u00e9z","year":"2005","unstructured":"Vald\u00e9z JC, Peral MC, Rachid M, Santana M, Perdig\u00f3n G (2005) Interference of Lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment. Clin Microbiol Infect 11(6):472\u20139. https:\/\/doi.org\/10.1111\/j.1469-0691.2005.01142.x","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"10780_CR97","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ijantimicag.2013.08.003","volume":"42","author":"H Sikorska","year":"2013","unstructured":"Sikorska H, Smoragiewicz W (2013) Role of probiotics in the prevention and treatment of meticillin-resistant Staphylococcus aureus infections. Int J Antimicrob Agents 42(6):475\u201381. https:\/\/doi.org\/10.1016\/j.ijantimicag.2013.08.003","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"10780_CR98","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1016\/S2666-5247(22)00322-6","volume":"4","author":"P Piewngam","year":"2023","unstructured":"Piewngam P, Khongthong S, Roekngam N, Theapparat Y, Sunpaweravong S, Faroongsarng D, Otto M (2023) Probiotic for pathogen-specific Staphylococcus aureus decolonization in Thailand: a phase 2, double-blind, randomized, placebo-controlled trial. Lancet Microbe 4(2):e75\u2013e83. https:\/\/doi.org\/10.1016\/S2666-5247(22)00322-6","journal-title":"Lancet Microbe"},{"issue":"6","key":"10780_CR99","doi-asserted-by":"publisher","first-page":"68","DOI":"10.14715\/cmb\/2025.71.6.9","volume":"71","author":"M Baazeem","year":"2025","unstructured":"Baazeem M, Niazy A, Rabea S, Alomiery AA (2025) Inhibitory potential of probiotic strains against pathogens associated with osteomyelitis of the jaws: a quantitative MIC and MBC analysis. Cell Mol Biol (Noisy-le-grand) 71(6):68\u201374. https:\/\/doi.org\/10.14715\/cmb\/2025.71.6.9","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"10","key":"10780_CR100","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/nri3312","volume":"12","author":"TR Klaenhammer","year":"2012","unstructured":"Klaenhammer TR, Kleerebezem M, Kopp MV, Rescigno M (2012) The impact of probiotics and prebiotics on the immune system. Nat Rev Immunol 12(10):728\u201334. https:\/\/doi.org\/10.1038\/nri3312","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10780_CR101","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijmm.2009.08.005","volume":"300","author":"TA Oelschlaeger","year":"2010","unstructured":"Oelschlaeger TA (2010) Mechanisms of probiotic actions\u2013a review. Int J Med Microbiol 300(1):57\u201362","journal-title":"Int J Med Microbiol"},{"issue":"2","key":"10780_CR102","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10875-010-9457-7","volume":"31","author":"S Amdekar","year":"2011","unstructured":"Amdekar S, Singh V, Singh R, Sharma P, Keshav P, Kumar A (2011) Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines: Lactobacillus casei: COX-2 inhibitor. J Clin Immunol 31(2):147\u201354. https:\/\/doi.org\/10.1007\/s10875-010-9457-7","journal-title":"J Clin Immunol"},{"key":"10780_CR103","doi-asserted-by":"publisher","DOI":"10.3810\/psm.2008.12.11","author":"JM Fritz","year":"2008","unstructured":"Fritz JM, McDonald JR (2008) Osteomyelitis: approach to diagnosis and treatment. Phys Sportsmed. https:\/\/doi.org\/10.3810\/psm.2008.12.11","journal-title":"Phys Sportsmed"},{"issue":"4","key":"10780_CR104","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.jmii.2013.09.002","volume":"49","author":"WS Lee","year":"2016","unstructured":"Lee WS, Chen YC, Chen HP, Chen TH, Cheng CY (2016) Vertebral osteomyelitis caused by vancomycin-tolerant methicillin-resistant Staphylococcus aureus bacteremia: experience with teicoplanin plus fosfomycin combination therapy. J Microbiol Immunol Infect 49(4):600\u20133. https:\/\/doi.org\/10.1016\/j.jmii.2013.09.002","journal-title":"J Microbiol Immunol Infect"},{"key":"10780_CR105","doi-asserted-by":"publisher","first-page":"100081","DOI":"10.1016\/j.glmedi.2024.100081","volume":"2","author":"KA Sirwan","year":"2024","unstructured":"Sirwan KA, Safin H, Karzan Q, Radhwan HI, Abdulmalik F, Kochr AM, Mona GM (2024) Antimicrobial resistance: impacts, challenges, and future prospects. J Med Surg Public Health 2:100081. https:\/\/doi.org\/10.1016\/j.glmedi.2024.100081","journal-title":"J Med Surg Public Health"},{"issue":"3","key":"10780_CR106","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/BF03022650","volume":"54","author":"S Piechno","year":"2007","unstructured":"Piechno S, Seguin P, Gangneux JP (2007) Fong\u00e9mie \u00e0 Saccharomyces boulardii: m\u00e9fiez-vous de la levure [Saccharomyces boulardii fungal sepsis: beware of the yeast]. Can J Anaesth 54(3):245\u20136. https:\/\/doi.org\/10.1007\/BF03022650","journal-title":"Can J Anaesth"},{"issue":"1","key":"10780_CR107","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1177\/039463201402700120","volume":"27","author":"I Santino","year":"2014","unstructured":"Santino I, Alari A, Bono S, Teti E, Marangi M, Bernardini A, Magrini L, Di Somma S, Teggi A (2014) Saccharomyces cerevisiae fungemia, a possible consequence of the treatment of Clostridium difficile colitis with a probioticum. Int J Immunopathol Pharmacol 27(1):143\u20136. https:\/\/doi.org\/10.1177\/039463201402700120","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"2","key":"10780_CR108","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1186\/cc6843","volume":"12","author":"N Lolis","year":"2008","unstructured":"Lolis N, Veldekis D, Moraitou H, Kanavaki S, Velegraki A, Triandafyllidis C, Tasioudis C, Pefanis A, Pneumatikos I (2008) Saccharomyces boulardii fungaemia in an intensive care unit patient treated with caspofungin. Crit Care 12(2):414. https:\/\/doi.org\/10.1186\/cc6843","journal-title":"Crit Care"},{"issue":"5","key":"10780_CR109","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/MCG.0b013e318279abf0","volume":"47","author":"E Vahabnezhad","year":"2013","unstructured":"Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA (2013) Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol 47(5):437\u20139. https:\/\/doi.org\/10.1097\/MCG.0b013e318279abf0","journal-title":"J Clin Gastroenterol"},{"issue":"4","key":"10780_CR110","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1258\/095646206776253507","volume":"17","author":"D Ledoux","year":"2006","unstructured":"Ledoux D, Labombardi VJ, Karter D (2006) Lactobacillus acidophilus bacteraemia after use of a probiotic in a patient with AIDS and Hodgkin\u2019s disease. Int J STD AIDS 17(4):280\u20132. https:\/\/doi.org\/10.1258\/095646206776253507","journal-title":"Int J STD AIDS"},{"key":"10780_CR111","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-2-315","volume":"2","author":"C Tommasi","year":"2008","unstructured":"Tommasi C, Equitani F, Masala M, Ballardini M, Favaro M, Meledandri M, Fontana C, Narciso P, Nicastri E (2008) Diagnostic difficulties of Lactobacillus casei bacteraemia in immunocompetent patients: a case report. J Med Case Rep 2:315. https:\/\/doi.org\/10.1186\/1752-1947-2-315","journal-title":"J Med Case Rep"},{"issue":"4","key":"10780_CR112","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jpeds.2009.11.041","volume":"156","author":"A Ohishi","year":"2010","unstructured":"Ohishi A, Takahashi S, Ito Y, Ohishi Y, Tsukamoto K, Nanba Y, Ito N, Kakiuchi S, Saitoh A, Morotomi M, Nakamura T (2010) Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr 156(4):679\u201381. https:\/\/doi.org\/10.1016\/j.jpeds.2009.11.041","journal-title":"J Pediatr"},{"issue":"1","key":"10780_CR113","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1542\/peds.2004-2137","volume":"115","author":"MH Land","year":"2005","unstructured":"Land MH, Rouster-Stevens K, Woods CR, Cannon ML, Cnota J, Shetty AK (2005) Lactobacillus sepsis associated with probiotic therapy. Pediatrics 115(1):178\u201381. https:\/\/doi.org\/10.1542\/peds.2004-2137","journal-title":"Pediatrics"},{"issue":"Suppl 2","key":"10780_CR114","doi-asserted-by":"publisher","first-page":"S129","DOI":"10.1093\/cid\/civ085","volume":"60","author":"S Doron","year":"2015","unstructured":"Doron S, Snydman DR (2015) Risk and safety of probiotics. Clin Infect Dis 60(Suppl 2):S129-34. https:\/\/doi.org\/10.1093\/cid\/civ085","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10780_CR115","doi-asserted-by":"publisher","first-page":"e38049","DOI":"10.7759\/cureus.38049","volume":"15","author":"A Rahman","year":"2023","unstructured":"Rahman A, Alqaisi S, Nath J (2023) A case of Lactobacillus casei endocarditis associated with probiotic intake in an immunocompromised patient. Cureus 15(4):e38049. https:\/\/doi.org\/10.7759\/cureus.38049","journal-title":"Cureus"},{"issue":"4","key":"10780_CR116","doi-asserted-by":"publisher","first-page":"e57853","DOI":"10.7759\/cureus.57853","volume":"16","author":"D Corredor-Rengifo","year":"2024","unstructured":"Corredor-Rengifo D, Tello-Cajiao ME, Garc\u00eda-Molina FA, Montero-Riascos LF, Segura-Cheng JD (2024) Bacillus clausii bacteremia following probiotic use: a report of two cases. Cureus 16(4):e57853. https:\/\/doi.org\/10.7759\/cureus.57853","journal-title":"Cureus"},{"key":"10780_CR117","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s10096-025-05115-7","volume":"44","author":"PA Gallego Aristizabal","year":"2025","unstructured":"Gallego Aristizabal PA, Pel\u00e1ez Garc\u00eda S, Caicedo Espinosa JE et al (2025) Alkalihalobacillus clausii bacteremia after probiotic use for acute diarrhea: a case report. Eur J Clin Microbiol Infect Dis 44:1527\u20131529. https:\/\/doi.org\/10.1007\/s10096-025-05115-7","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"10780_CR118","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004548","volume":"44","author":"Kohei Ukai","year":"2025","unstructured":"Ukai Kohei, Okamoto Koh, Ichinose Akinori, Yoshida Mariko, Higurashi Yoshimi, Yoneda Ryu, Yamamoto Shuta, Asahara Takashi (2025) Lacticaseibacillus paracasei bacteremia associated with probiotic use in a child with hypoganglionosis: case report and literature review. Pediatr Infect Dis J 44(2):e56\u2013e59. https:\/\/doi.org\/10.1097\/INF.0000000000004548","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10780_CR119","doi-asserted-by":"publisher","first-page":"e54879","DOI":"10.7759\/cureus.54879","volume":"16","author":"UJ Eze","year":"2024","unstructured":"Eze UJ, Lal A, Elkoush MI, Halytska M, Atif S (2024) Recurrent Lactobacillus rhamnoses bacteremia and complications in an immunocompromised patient with history of probiotic use: a case report. Cureus 16(2):e54879. https:\/\/doi.org\/10.7759\/cureus.54879","journal-title":"Cureus"},{"key":"10780_CR120","unstructured":"National Institutes of Health. Probiotics: fact sheet for health professionals"},{"issue":"4","key":"10780_CR121","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3390\/cells11040743","volume":"11","author":"A de Sire","year":"2022","unstructured":"de Sire A, de Sire R, Curci C, Castiglione F, Wahli W (2022) Role of dietary supplements and probiotics in modulating microbiota and bone health: the gut-bone axis. Cells 11(4):743. https:\/\/doi.org\/10.3390\/cells11040743","journal-title":"Cells"},{"issue":"1","key":"10780_CR122","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s12602-024-10311-6","volume":"17","author":"M Heidarrezaei","year":"2025","unstructured":"Heidarrezaei M, Mauriello G, Shokravi H, Lau WJ, Ismail AF (2025) Delivery of probiotic-loaded microcapsules in the gastrointestinal tract: a review. Probiotics Antimicrob Proteins 17(1):193\u2013211. https:\/\/doi.org\/10.1007\/s12602-024-10311-6","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"6","key":"10780_CR123","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/02652048.2021.1949062","volume":"38","author":"R Iqbal","year":"2021","unstructured":"Iqbal R, Liaqat A, Jahangir Chughtai MF, Tanweer S, Tehseen S, Ahsan S, Nadeem M, Mehmood T, Ur Rehman SJ, Saeed K, Sameed N, Aziz S, Tahir AB, Khaliq A (2021) Microencapsulation: a pragmatic approach towards delivery of probiotics in gut. J Microencapsul 38(6):437\u2013458. https:\/\/doi.org\/10.1080\/02652048.2021.1949062","journal-title":"J Microencapsul"},{"issue":"2","key":"10780_CR124","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1111\/1541-4337.12532","volume":"19","author":"M Yao","year":"2020","unstructured":"Yao M, Xie J, Du H, McClements DJ, Xiao H, Li L (2020) Progress in microencapsulation of probiotics: a review. Compr Rev Food Sci Food Saf 19(2):857\u2013874. https:\/\/doi.org\/10.1111\/1541-4337.12532","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"8","key":"10780_CR125","doi-asserted-by":"publisher","first-page":"4679","DOI":"10.1007\/s13197-014-1516-2","volume":"52","author":"S Iravani","year":"2015","unstructured":"Iravani S, Korbekandi H, Mirmohammadi SV (2015) Technology and potential applications of probiotic encapsulation in fermented milk products. J Food Sci Technol 52(8):4679\u201396. https:\/\/doi.org\/10.1007\/s13197-014-1516-2","journal-title":"J Food Sci Technol"},{"issue":"9","key":"10780_CR126","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1080\/10408398.2020.1761773","volume":"61","author":"G Frakolaki","year":"2021","unstructured":"Frakolaki G, Giannou V, Kekos D, Tzia C (2021) A review of the microencapsulation techniques for the incorporation of probiotic bacteria in functional foods. Crit Rev Food Sci Nutr 61(9):1515\u20131536. https:\/\/doi.org\/10.1080\/10408398.2020.1761773","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"10780_CR127","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jconrel.2011.04.002","volume":"154","author":"C Maderuelo","year":"2011","unstructured":"Maderuelo C, Zarzuelo A, Lanao JM (2011) Critical factors in the release of drugs from sustained release hydrophilic matrices. J Control Release 154(1):2\u201319. https:\/\/doi.org\/10.1016\/j.jconrel.2011.04.002","journal-title":"J Control Release"},{"issue":"3","key":"10780_CR128","first-page":"170","volume":"96","author":"T Wilkins","year":"2017","unstructured":"Wilkins T, Sequoia J (2017) Probiotics for gastrointestinal conditions: a summary of the evidence. Am Fam Physician 96(3):170\u2013178","journal-title":"Am Fam Physician"},{"key":"10780_CR129","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ejps.2018.05.022","volume":"121","author":"J Mirti\u010d","year":"2018","unstructured":"Mirti\u010d J, Rijavec T, Zupan\u010di\u010d \u0160, Zvonar Pobirk A, Lapanje A, Kristl J (2018) Development of probiotic-loaded microcapsules for local delivery: physical properties, cell release and growth. Eur J Pharm Sci 121:178\u2013187. https:\/\/doi.org\/10.1016\/j.ejps.2018.05.022","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"10780_CR130","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s12602-024-10311-6","volume":"17","author":"M Heidarrezaei","year":"2025","unstructured":"Heidarrezaei M, Mauriello G, Shokravi H, Lau WJ, Ismail AF (2025) Delivery of probiotic-loaded microcapsules in the gastrointestinal tract: a review. Probiotics Antimicrob Proteins 17(1):193\u2013211","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10780_CR131","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00347","volume":"6","author":"E Esaiassen","year":"2018","unstructured":"Esaiassen E, Hjerde E, Cavanagh JP, Pedersen T, Andresen JH, Rettedal SI, St\u00f8en R, Nakstad B, Willassen NP, Klingenberg C (2018) Effects of probiotic supplementation on the gut microbiota and antibiotic resistome development in preterm infants. Front Pediatr 6:347. https:\/\/doi.org\/10.3389\/fped.2018.00347","journal-title":"Front Pediatr"},{"issue":"310","key":"10780_CR132","doi-asserted-by":"publisher","first-page":"125977","DOI":"10.1016\/j.foodchem.2019.125977","volume":"25","author":"K Feng","year":"2020","unstructured":"Feng K, Huang RM, Wu RQ, Wei YS, Zong MH, Linhardt RJ, Wu H (2020) A novel route for double-layered encapsulation of probiotics with improved viability under adverse conditions. Food Chem 25(310):125977. https:\/\/doi.org\/10.1016\/j.foodchem.2019.125977","journal-title":"Food Chem"},{"issue":"1","key":"10780_CR133","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hjb.2016.12.008","volume":"24","author":"AB Shori","year":"2017","unstructured":"Shori AB (2017) Microencapsulation improved probiotics survival during gastric transit. HAYATI J Biosci 24(1):1\u20135","journal-title":"HAYATI J Biosci"},{"issue":"11","key":"10780_CR134","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112436","volume":"14","author":"P Srivastava","year":"2022","unstructured":"Srivastava P, Sondak T, Sivashanmugam K, Kim KS (2022) A review of immunomodulatory reprogramming by probiotics in combating chronic and acute diabetic foot ulcers (DFUs). Pharmaceutics 14(11):2436. https:\/\/doi.org\/10.3390\/pharmaceutics14112436","journal-title":"Pharmaceutics"},{"issue":"210","key":"10780_CR135","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.110018","volume":"15","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Wang Z, Bai L, Deng J, Zhou Q (2021) Biomaterial-based encapsulated probiotics for biomedical applications: current status and future perspectives. Mater Des 15(210):110018","journal-title":"Mater Des"},{"issue":"1","key":"10780_CR136","first-page":"35","volume":"3","author":"T Amin","year":"2013","unstructured":"Amin T, Thakur M, Jain SC (2013) Microencapsulation-the future of probiotic cultures. J Microbiol Biotechnol Food Sci 3(1):35\u201343","journal-title":"J Microbiol Biotechnol Food Sci"},{"key":"10780_CR137","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fmicb.2019.00142","volume":"10","author":"L Hong","year":"2019","unstructured":"Hong L, Kim WS, Lee SM, Kang SK, Choi YJ, Cho CS (2019) Pullulan nanoparticles as prebiotics enhance the antibacterial properties of Lactobacillus plantarum through the induction of mild stress in probiotics. Front Microbiol 10:142. https:\/\/doi.org\/10.3389\/fmicb.2019.00142","journal-title":"Front Microbiol"},{"key":"10780_CR138","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ijpharm.2015.03.078","volume":"487","author":"MJM Villena","year":"2015","unstructured":"Villena MJM, Lara-Villoslada F, Mart\u00ednez MAR, Hern\u00e1ndez MEM (2015) Development of gastro-resistant tablets for the protection and intestinal delivery of Lactobacillus fermentum cect 5716. Int J Pharm 487:314\u2013319","journal-title":"Int J Pharm"},{"key":"10780_CR139","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jconrel.2022.10.030","volume":"352","author":"N Luo","year":"2022","unstructured":"Luo N, De Souza Y, Ramachandran C, Wang M, Yi S, Ma H, Zhang Z, Lin LK (2022) Precise oral delivery systems for probiotics: a review. J Control Release 352:371\u2013384","journal-title":"J Control Release"},{"issue":"2","key":"10780_CR140","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3390\/polym17020144","volume":"17","author":"ZD Wang","year":"2025","unstructured":"Wang ZD, Zhang W, Liang TX (2025) Advancements in oral delivery systems for probiotics based on polysaccharides. Polymers 17(2):144. https:\/\/doi.org\/10.3390\/polym17020144","journal-title":"Polymers"},{"issue":"3","key":"10780_CR141","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3390\/fermentation8030117","volume":"8","author":"AJ Garcia-Brand","year":"2022","unstructured":"Garcia-Brand AJ, Quezada V, Gonzalez-Melo C, Bola\u00f1os-Barbosa AD, Cruz JC, Reyes LH (2022) Novel developments on stimuli-responsive probiotic encapsulates: from smart hydrogels to nanostructured platforms. Fermentation 8(3):117. https:\/\/doi.org\/10.3390\/fermentation8030117","journal-title":"Fermentation"},{"key":"10780_CR142","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.addr.2020.07.014","volume":"161\u2013162","author":"S Asgari","year":"2020","unstructured":"Asgari S, Pourjavadi A, Licht TR, Boisen A, Ajalloueian F (2020) Polymeric carriers for enhanced delivery of probiotics. Adv Drug Deliv Rev 161\u2013162:1\u201321. https:\/\/doi.org\/10.1016\/j.addr.2020.07.014","journal-title":"Adv Drug Deliv Rev"},{"issue":"9","key":"10780_CR143","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1080\/10408398.2011.573152","volume":"53","author":"T Huq","year":"2013","unstructured":"Huq T, Khan A, Khan RA, Riedl B, Lacroix M (2013) Encapsulation of probiotic bacteria in biopolymeric system. Crit Rev Food Sci Nutr 53(9):909\u201316. https:\/\/doi.org\/10.1080\/10408398.2011.573152","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"10780_CR144","doi-asserted-by":"publisher","first-page":"52","DOI":"10.17113\/ftb.54.01.16.4234","volume":"54","author":"M Seyedain-Ardabili","year":"2016","unstructured":"Seyedain-Ardabili M, Sharifan A, Tarzi BG (2016) The production of synbiotic bread by microencapsulation. Food Technol Biotechnol 54(1):52\u201359. https:\/\/doi.org\/10.17113\/ftb.54.01.16.4234","journal-title":"Food Technol Biotechnol"},{"key":"10780_CR145","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116965","volume":"250","author":"T Jayani","year":"2020","unstructured":"Jayani T, Sanjeev B, Marimuthu S, Uthandi S (2020) Bacterial cellulose nano fiber (BCNF) as carrier support for the immobilization of probiotic, Lactobacillus acidophilus 016. Carbohydr Polym 250:116965. https:\/\/doi.org\/10.1016\/j.carbpol.2020.116965","journal-title":"Carbohydr Polym"},{"issue":"116","key":"10780_CR146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106192","volume":"1","author":"J Arratia-Quijada","year":"2024","unstructured":"Arratia-Quijada J, Nu\u00f1o K, Ru\u00edz-Santoyo V, Andrade-Espinoza BA (2024) Nano-encapsulation of probiotics: need and critical considerations to design new non-dairy probiotic products. J Funct Foods 1(116):106192","journal-title":"J Funct Foods"},{"issue":"10","key":"10780_CR147","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1039\/d0na00952k","volume":"3","author":"S Razavi","year":"2021","unstructured":"Razavi S, Janfaza S, Tasnim N, Gibson DL, Hoorfar M (2021) Nanomaterial-based encapsulation for controlled gastrointestinal delivery of viable probiotic bacteria. Nanoscale Adv 3(10):2699\u20132709. https:\/\/doi.org\/10.1039\/d0na00952k","journal-title":"Nanoscale Adv"},{"key":"10780_CR148","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejpb.2019.01.013","volume":"136","author":"K \u0160krlec","year":"2019","unstructured":"\u0160krlec K, Zupan\u010di\u010d \u0160, Prpar Mihevc S, Kocbek P, Kristl J, Berlec A (2019) Development of electrospun nanofibers that enable high loading and long-term viability of probiotics. Eur J Pharm Biopharm 136:108\u2013119. https:\/\/doi.org\/10.1016\/j.ejpb.2019.01.013","journal-title":"Eur J Pharm Biopharm"},{"key":"10780_CR149","doi-asserted-by":"publisher","first-page":"107216","DOI":"10.1016\/j.foodhyd.2021.107216","volume":"124","author":"C Xu","year":"2022","unstructured":"Xu C, Ma J, Wang W, Liu Z, Gu L, Qian S, Hou J, Jiang Z (2022) Preparation of pectin-based nanofibers encapsulating Lactobacillus rhamnosus 1.0320 by electrospinning. Food Hydrocolloids 124:107216","journal-title":"Food Hydrocolloids"},{"issue":"123","key":"10780_CR150","doi-asserted-by":"publisher","first-page":"107112","DOI":"10.1016\/j.foodhyd.2021.107112","volume":"1","author":"F Ajalloueian","year":"2022","unstructured":"Ajalloueian F, Guerra PR, Bahl MI, Torp AM, Te Hwu E, Licht TR, Boisen A (2022) Multi-layer PLGA-pullulan-PLGA electrospun nanofibers for probiotic delivery. Food Hydrocolloids 1(123):107112","journal-title":"Food Hydrocolloids"},{"key":"10780_CR151","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116447","volume":"244","author":"MT Yilmaz","year":"2020","unstructured":"Yilmaz MT, Taylan O, Karakas CY, Dertli E (2020) An alternative way to encapsulate probiotics within electrospun alginate nanofibers as monitored under simulated gastrointestinal conditions and in kefir. Carbohydr Polym 244:116447. https:\/\/doi.org\/10.1016\/j.carbpol.2020.116447","journal-title":"Carbohydr Polym"},{"issue":"1","key":"10780_CR152","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13010086","volume":"13","author":"A Naskar","year":"2021","unstructured":"Naskar A, Kim KS (2021) Potential novel food-related and biomedical applications of nanomaterials combined with bacteriocins. Pharmaceutics 13(1):86. https:\/\/doi.org\/10.3390\/pharmaceutics13010086","journal-title":"Pharmaceutics"},{"issue":"9","key":"10780_CR153","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1111\/1750-3841.16709","volume":"88","author":"M Adeel","year":"2023","unstructured":"Adeel M, Afzaal M, Saeed F, Ahmed A, Mahmood K, Abbas Shah Y, Ateeq H, Sibat A, Khan MR, Busquets R (2023) Encapsulation of probiotic bacteria using polyelectrolytes stabilized nanoliposomes for improved viability under hostile conditions. J Food Sci 88(9):3839\u20133848. https:\/\/doi.org\/10.1111\/1750-3841.16709","journal-title":"J Food Sci"},{"key":"10780_CR154","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131358","volume":"372","author":"SF Hosseini","year":"2022","unstructured":"Hosseini SF, Ansari B, Gharsallaoui A (2022) Polyelectrolytes-stabilized liposomes for efficient encapsulation of Lactobacillus rhamnosus and improvement of its survivability under adverse conditions. Food Chem 372:131358. https:\/\/doi.org\/10.1016\/j.foodchem.2021.131358","journal-title":"Food Chem"},{"key":"10780_CR155","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2022.102781","volume":"309","author":"Q Gu","year":"2022","unstructured":"Gu Q, Yin Y, Yan X, Liu X, Liu F, McClements DJ (2022) Encapsulation of multiple probiotics, synbiotics, or nutrabiotics for improved health effects: a review. Adv Colloid Interface Sci 309:102781. https:\/\/doi.org\/10.1016\/j.cis.2022.102781","journal-title":"Adv Colloid Interface Sci"},{"issue":"121","key":"10780_CR156","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2019.108928","volume":"1","author":"L Wang","year":"2020","unstructured":"Wang L, Song M, Zhao Z, Chen X, Cai J, Cao Y, Xiao J (2020) Lactobacillus acidophilus loaded pickering double emulsion with enhanced viability and colon-adhesion efficiency. LWT 1(121):108928","journal-title":"LWT"},{"key":"10780_CR157","unstructured":"Alemzadeh I, Hajiabbas M (2020) Encapsulation of food components and bioactive ingredients and targeted release. Int J Eng"},{"issue":"71","key":"10780_CR158","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.lwt.2016.04.012","volume":"1","author":"AT Holkem","year":"2016","unstructured":"Holkem AT, Raddatz GC, Nunes GL, Cichoski AJ, Jacob-Lopes E, Grosso CR, de Menezes CR (2016) Development and characterization of alginate microcapsules containing Bifidobacterium BB-12 produced by emulsification\/internal gelation followed by freeze drying. LWT-Food Sci Technol 1(71):302\u20138","journal-title":"LWT-Food Sci Technol"},{"key":"10780_CR159","doi-asserted-by":"publisher","first-page":"S148","DOI":"10.1016\/j.matpr.2020.05.008","volume":"40","author":"S Vaishanavi","year":"2021","unstructured":"Vaishanavi S, Preetha R (2021) Soy protein incorporated nanoemulsion for enhanced stability of probiotic (Lactobacillus delbrueckii subsp. bulgaricus) and its characterization. Mater Today Proc 40:S148-53","journal-title":"Mater Today Proc"},{"issue":"1","key":"10780_CR160","first-page":"e40443","volume":"8","author":"M Sadeghi-Naini","year":"2017","unstructured":"Sadeghi-Naini M, Sabagh M, Yamini A, Nakhjavani F, Siavashi B, Hing CB (2017) Investigating the therapeutic potential of a probiotic in a rat model for infection following fracture fixation. Asian J Sports Med 8(1):e40443","journal-title":"Asian J Sports Med"},{"issue":"9","key":"10780_CR161","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1086\/340126","volume":"185","author":"BS Gan","year":"2002","unstructured":"Gan BS, Kim J, Reid G, Cadieux P, Howard JC (2002) Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats. J Infect Dis 185(9):1369\u201372. https:\/\/doi.org\/10.1086\/340126","journal-title":"J Infect Dis"},{"issue":"8","key":"10780_CR162","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1073\/pnas.1716580115","volume":"115","author":"E V\u00e5gesj\u00f6","year":"2018","unstructured":"V\u00e5gesj\u00f6 E, \u00d6hnstedt E, Mortier A, Lofton H, Huss F, Proost P, Roos S, Phillipson M (2018) Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria. Proc Natl Acad Sci U S A 115(8):1895\u20131900. https:\/\/doi.org\/10.1073\/pnas.1716580115","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10780_CR163","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1017\/S0007114507787469","volume":"98","author":"H Kimoto-Nira","year":"2007","unstructured":"Kimoto-Nira H, Suzuki C, Kobayashi M, Sasaki K, Kurisaki J, Mizumachi K (2007) Anti-aging effect of a lactococcal strain: analysis using senescence-accelerated mice. Br J Nutr 98(6):1178\u201386. https:\/\/doi.org\/10.1017\/S0007114507787469","journal-title":"Br J Nutr"},{"key":"10780_CR164","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2970","author":"S Mohseni","year":"2018","unstructured":"Mohseni S, Bayani M, Bahmani F, Tajabadi-Ebrahimi M, Bayani MA, Jafari P, Asemi Z (2018) The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Diabetes Metab Res Rev. https:\/\/doi.org\/10.1002\/dmrr.2970","journal-title":"Diabetes Metab Res Rev"},{"issue":"10","key":"10780_CR165","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/jbm.b.34821","volume":"109","author":"A Jeyanathan","year":"2021","unstructured":"Jeyanathan A, Ramalhete R, Blunn G, Gibbs H, Pumilia CA, Meckmongkol T, Lovejoy J, Coathup MJ (2021) Lactobacillus cell-free supernatant as a novel bioagent and biosurfactant against Pseudomonas aeruginosa in the prevention and treatment of orthopedic implant infection. J Biomed Mater Res B Appl Biomater 109(10):1634\u20131643. https:\/\/doi.org\/10.1002\/jbm.b.34821","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"9","key":"10780_CR166","doi-asserted-by":"publisher","DOI":"10.3390\/ani14091369","volume":"14","author":"ADT Do","year":"2024","unstructured":"Do ADT, Anthney A, Alharbi K, Asnayanti A, Meuter A, Alrubaye AAK (2024) Assessing the impact of spraying an Enterococcus faecium-based probiotic on day-old broiler chicks at hatch on the incidence of bacterial chondronecrosis with osteomyelitis lameness using a Staphylococcus challenge model. Animals (Basel) 14(9):1369. https:\/\/doi.org\/10.3390\/ani14091369","journal-title":"Animals (Basel)"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10780-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10780-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10780-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:58:12Z","timestamp":1778749092000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10780-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":166,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10780"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10780-3","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"21 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}