{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:22:14Z","timestamp":1778750534060,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Major investment project of Shanghai science and technology service industry","award":["24KF3501200"],"award-info":[{"award-number":["24KF3501200"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12602-025-10788-9","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T07:18:00Z","timestamp":1759907880000},"page":"4610-4620","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Screening and Genetic Analysis of Bifidobacterium longum subsp. Longum dipro-X for IBD Alleviation"],"prefix":"10.1007","volume":"18","author":[{"given":"Yanqing","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"10788_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110784","volume":"131","author":"D Lu","year":"2020","unstructured":"Lu D, Huang Y, Kong Y, Tao T, Zhu X (2020) Gut microecology: why our microbes could be key to our health. Biomed Pharmacother 131:110784. https:\/\/doi.org\/10.1016\/j.biopha.2020.110784","journal-title":"Biomed Pharmacother"},{"key":"10788_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1225120","volume":"10","author":"S Pedroza Matute","year":"2023","unstructured":"Pedroza Matute S, Iyavoo S (2023) Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics. Front Nutr 10:1225120. https:\/\/doi.org\/10.3389\/fnut.2023.1225120","journal-title":"Front Nutr"},{"issue":"1","key":"10788_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-020-01066-8","volume":"10","author":"O Bajinka","year":"2020","unstructured":"Bajinka O, Tan Y, Abdelhalim KA, Ozdemir G, Qiu X (2020) Extrinsic factors influencing gut microbes, the immediate consequences and restoring eubiosis. AMB Express 10(1):130. https:\/\/doi.org\/10.1186\/s13568-020-01066-8","journal-title":"AMB Express"},{"issue":"2","key":"10788_CR4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.biopsycho.2007.09.010","volume":"77","author":"SR Knowles","year":"2008","unstructured":"Knowles SR, Nelson EA, Palombo EA (2008) Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: a possible mechanism underlying susceptibility to illness. Biol Psychol 77(2):132\u2013137. https:\/\/doi.org\/10.1016\/j.biopsycho.2007.09.010","journal-title":"Biol Psychol"},{"key":"10788_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-14-189","volume":"14","author":"JD Galley","year":"2014","unstructured":"Galley JD, Nelson MC, Yu Z, Dowd SE, Walter J, Kumar PS, Lyte M, Bailey MT (2014) Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota. BMC Microbiol 14:189. https:\/\/doi.org\/10.1186\/1471-2180-14-189","journal-title":"BMC Microbiol"},{"key":"10788_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.bbr.2018.02.005","volume":"345","author":"KA Partrick","year":"2018","unstructured":"Partrick KA, Chassaing B, Beach LQ, McCann KE, Gewirtz AT, Huhman KL (2018) Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters. Behav Brain Res 345:39\u201348. https:\/\/doi.org\/10.1016\/j.bbr.2018.02.005","journal-title":"Behav Brain Res"},{"issue":"10114","key":"10788_CR7","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL et al (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390(10114):2769\u20132778. https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0","journal-title":"Lancet"},{"issue":"8","key":"10788_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"C Chelakkot","year":"2018","unstructured":"Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50(8):1\u20139. https:\/\/doi.org\/10.1038\/s12276-018-0126-x","journal-title":"Exp Mol Med"},{"key":"10788_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1108289","volume":"14","author":"S Lechuga","year":"2023","unstructured":"Lechuga S, Braga-Neto MB, Naydenov NG, Rieder F, Ivanov AI (2023) Understanding disruption of the gut barrier during inflammation: should we abandon traditional epithelial cell lines and switch to intestinal organoids? Front Immunol 14:1108289. https:\/\/doi.org\/10.3389\/fimmu.2023.1108289","journal-title":"Front Immunol"},{"key":"10788_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.pharmthera.2014.12.006","volume":"149","author":"G Cammarota","year":"2015","unstructured":"Cammarota G, Ianiro G, Cianci R, Bibbo S, Gasbarrini A, Curro D (2015) The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy. Pharmacol Ther 149:191\u2013212. https:\/\/doi.org\/10.1016\/j.pharmthera.2014.12.006","journal-title":"Pharmacol Ther"},{"issue":"32","key":"10788_CR11","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.2174\/0113816128318032240702045822","volume":"30","author":"AH Barjasteh","year":"2024","unstructured":"Barjasteh AH, Al-Asady AM, Latifi H, Al Okla S, Al-Nazwani N, Avan A, Khazaei M, Ryzhikov M, Nadi-Yazdi H, Hassanian SM (2024) Maximizing treatment options for IBD through drug repurposing. Curr Pharm Des 30(32):2538\u20132549. https:\/\/doi.org\/10.2174\/0113816128318032240702045822","journal-title":"Curr Pharm Des"},{"issue":"6","key":"10788_CR12","doi-asserted-by":"publisher","first-page":"832","DOI":"10.14309\/ajg.0000000000000608","volume":"115","author":"JJ Rozich","year":"2020","unstructured":"Rozich JJ, Holmer A, Singh S (2020) Effect of lifestyle factors on outcomes in patients with inflammatory bowel diseases. Am J Gastroenterol 115(6):832\u2013840. https:\/\/doi.org\/10.14309\/ajg.0000000000000608","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10788_CR13","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s00464-010-1275-8","volume":"25","author":"KJ Gash","year":"2011","unstructured":"Gash KJ, Goede AC, Chambers W, Greenslade GL, Dixon AR (2011) Laparoendoscopic single-site surgery is feasible in complex colorectal resections and could enable day case colectomy. Surg Endosc 25(3):835\u2013840. https:\/\/doi.org\/10.1007\/s00464-010-1275-8","journal-title":"Surg Endosc"},{"issue":"2","key":"10788_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jsps.2013.02.003","volume":"22","author":"MJ Alomar","year":"2014","unstructured":"Alomar MJ (2014) Factors affecting the development of adverse drug reactions (review article). Saudi Pharm J 22(2):83\u201394. https:\/\/doi.org\/10.1016\/j.jsps.2013.02.003","journal-title":"Saudi Pharm J"},{"issue":"5","key":"10788_CR15","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004FromNLMMedline","volume":"17","author":"F Backhed","year":"2015","unstructured":"Backhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, Li Y, Xia Y, Xie H, Zhong H et al (2015) Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host Microbe 17(5):690\u2013703. https:\/\/doi.org\/10.1016\/j.chom.2015.04.004FromNLMMedline","journal-title":"Cell Host Microbe"},{"key":"10788_CR16","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00036-17","author":"C Milani","year":"2017","unstructured":"Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J, Belzer C, Delgado Palacio S, Arboleya Montes S, Mancabelli L et al (2017) The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev. https:\/\/doi.org\/10.1128\/MMBR.00036-17","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"10788_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-022-01411-z","volume":"12","author":"Y Dong","year":"2022","unstructured":"Dong Y, Liao W, Tang J, Fei T, Gai Z, Han M (2022) Bifidobacterium BLa80 mitigates colitis by altering gut microbiota and alleviating inflammation. AMB Express 12(1):67. https:\/\/doi.org\/10.1186\/s13568-022-01411-z","journal-title":"AMB Express"},{"issue":"37","key":"10788_CR18","doi-asserted-by":"publisher","first-page":"11678","DOI":"10.1021\/acs.jafc.2c02909","volume":"70","author":"J Shang","year":"2022","unstructured":"Shang J, Yang S, Tang Z, Chen Y, Duan B, Meng X (2022) Bifidobacterium bifidum H3\u2013R2 and its molecular communication within the context of ulcerative colitis. J Agric Food Chem 70(37):11678\u201311688. https:\/\/doi.org\/10.1021\/acs.jafc.2c02909","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10788_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75702-5","volume":"10","author":"S Singh","year":"2020","unstructured":"Singh S, Bhatia R, Khare P, Sharma S, Rajarammohan S, Bishnoi M, Bhadada SK, Sharma SS, Kaur J, Kondepudi KK (2020) Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice. Sci Rep 10(1):18597. https:\/\/doi.org\/10.1038\/s41598-020-75702-5","journal-title":"Sci Rep"},{"issue":"3","key":"10788_CR20","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1039\/c9fo00014c","volume":"10","author":"S Yan","year":"2019","unstructured":"Yan S, Yang B, Zhao J, Zhao J, Stanton C, Ross RP, Zhang H, Chen W (2019) A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation. Food Funct 10(3):1595\u20131608. https:\/\/doi.org\/10.1039\/c9fo00014c","journal-title":"Food Funct"},{"issue":"4","key":"10788_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175935","volume":"12","author":"LS Celiberto","year":"2017","unstructured":"Celiberto LS, Bedani R, Dejani NN, Ivo de Medeiros A, Sampaio Zuanon JA, Spolidorio LC, Tallarico Adorno MA, Amancio Varesche MB, Carrilho Galvao F, Valentini SR et al (2017) Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis. PLoS One 12(4):e0175935. https:\/\/doi.org\/10.1371\/journal.pone.0175935. From NLM Medline","journal-title":"PLoS One"},{"key":"10788_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.nutres.2019.03.008","volume":"67","author":"H Kim","year":"2019","unstructured":"Kim H, Kim JK, Kim JY, Jang SE, Han MJ, Kim DH (2019) Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 simultaneously alleviate high-fat diet-induced colitis, endotoxemia, liver steatosis, and obesity in mice. Nutr Res 67:78\u201389. https:\/\/doi.org\/10.1016\/j.nutres.2019.03.008","journal-title":"Nutr Res"},{"issue":"14","key":"10788_CR23","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1093\/nar\/gkw569","volume":"44","author":"T Tatusova","year":"2016","unstructured":"Tatusova T, DiCuccio M, Badretdin A, Chetvernin V, Nawrocki EP, Zaslavsky L, Lomsadze A, Pruitt KD, Borodovsky M, Ostell J (2016) NCBI prokaryotic genome annotation pipeline. Nucleic Acids Res 44(14):6614\u20136624. https:\/\/doi.org\/10.1093\/nar\/gkw569","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10788_CR24","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1093\/bioinformatics\/btt086","volume":"29","author":"A Gurevich","year":"2013","unstructured":"Gurevich A, Saveliev V, Vyahhi N, Tesler G (2013) QUAST: quality assessment tool for genome assemblies. Bioinformatics 29(8):1072\u20131075. https:\/\/doi.org\/10.1093\/bioinformatics\/btt086","journal-title":"Bioinformatics"},{"issue":"14","key":"10788_CR25","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","volume":"30","author":"T Seemann","year":"2014","unstructured":"Seemann T (2014) Prokka: rapid prokaryotic genome annotation. Bioinformatics 30(14):2068\u20132069. https:\/\/doi.org\/10.1093\/bioinformatics\/btu153","journal-title":"Bioinformatics"},{"issue":"22","key":"10788_CR26","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1093\/bioinformatics\/btv421","volume":"31","author":"AJ Page","year":"2015","unstructured":"Page AJ, Cummins CA, Hunt M, Wong VK, Reuter S, Holden MT, Fookes M, Falush D, Keane JA, Parkhill J (2015) Roary: rapid large-scale prokaryote pan genome analysis. Bioinformatics 31(22):3691\u20133693. https:\/\/doi.org\/10.1093\/bioinformatics\/btv421","journal-title":"Bioinformatics"},{"key":"10788_CR27","doi-asserted-by":"publisher","unstructured":"Chen L, Yang J, Yu J, Yao Z, Sun L, Shen Y, Jin Q (2005) VFDB: a reference database for bacterial virulence factors. Nucleic Acids Res 33(Database issue):D325\u2013328. https:\/\/doi.org\/10.1093\/nar\/gki008. From NLM Medline","DOI":"10.1093\/nar\/gki008"},{"key":"10788_CR28","unstructured":"Xu T, Si J, Yan M, Lu B, Liu X, Wang Y, Geng W (2023) Whole genome sequencing analysis of Bifidobacterium longum W13. Food Res Dev 44(18):185\u2013192. From Cnki"},{"key":"10788_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.777147","volume":"12","author":"H Hao","year":"2021","unstructured":"Hao H, Zhang X, Tong L, Liu Q, Liang X, Bu Y, Gong P, Liu T, Zhang L, Xia Y et al (2021) Effect of extracellular vesicles derived from Lactobacillus plantarum Q7 on gut microbiota and ulcerative colitis in mice. Front Immunol 12:777147. https:\/\/doi.org\/10.3389\/fimmu.2021.777147","journal-title":"Front Immunol"},{"issue":"3","key":"10788_CR30","doi-asserted-by":"publisher","first-page":"372","DOI":"10.5507\/bp.2016.044FromNLMMedline","volume":"160","author":"VD Palumbo","year":"2016","unstructured":"Palumbo VD, Romeo M, Marino Gammazza A, Carini F, Damiani P, Damiano G, Buscemi S, Lo Monte AI, Gerges-Geagea A, Jurjus A et al (2016) The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 160(3):372\u2013377. https:\/\/doi.org\/10.5507\/bp.2016.044FromNLMMedline","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10788_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102080","author":"JW Yoo","year":"2022","unstructured":"Yoo JW, Shin YJ, Ma X, Son YH, Jang HM, Lee CK, Kim DH (2022) The alleviation of gut microbiota-induced depression and colitis in mice by anti-inflammatory probiotics NK151, NK173, and NK175. Nutrients. https:\/\/doi.org\/10.3390\/nu14102080","journal-title":"Nutrients"},{"issue":"19","key":"10788_CR32","doi-asserted-by":"publisher","first-page":"5985","DOI":"10.3748\/wjg.v21.i19.5985FromNLMMedline","volume":"21","author":"Y Yoshimatsu","year":"2015","unstructured":"Yoshimatsu Y, Yamada A, Furukawa R, Sono K, Osamura A, Nakamura K, Aoki H, Tsuda Y, Hosoe N, Takada N et al (2015) Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis. World J Gastroenterol 21(19):5985\u20135994. https:\/\/doi.org\/10.3748\/wjg.v21.i19.5985FromNLMMedline","journal-title":"World J Gastroenterol"},{"key":"10788_CR33","doi-asserted-by":"publisher","unstructured":"Hao R, Liu Q, Wang L, Jian W, Cheng Y, Zhang Q, Hayer K, Kamarudin Raja Idris R, Zhang Y, Lu H et al (2023) Anti-inflammatory effect of Lactiplantibacillus plantarum T1 cell-free supernatants through suppression of oxidative stress and NF-\u03baB- and MAPK-signaling pathways. Appl Environ Microbiol 89(10):e0060823. https:\/\/doi.org\/10.1128\/aem.00608-23. IF: 3.7 Q2","DOI":"10.1128\/aem.00608-23"},{"key":"10788_CR34","doi-asserted-by":"publisher","unstructured":"Woo IK, Hyun JH, Jang HJ, Lee NK, Paik HD (2024) Probiotic pediococcus acidilactici strains exert anti-inflammatory effects by regulating intracellular signaling pathways in lps-induced raw 264.7 cells. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10263-x. From NLM Publisher","DOI":"10.1007\/s12602-024-10263-x"},{"key":"10788_CR35","doi-asserted-by":"publisher","unstructured":"Ma X, Xie B, Du J, Zhang A, Hao J, Wang S, Wang J, Cao G (2017) The anti-inflammatory effect and structure of epcp1-2 from crypthecodinium cohnii via modulation of tlr4-nf-kappab pathways in lps-induced raw 264.7 cells. Mar Drugs 15(12). https:\/\/doi.org\/10.3390\/md15120376.\u00a0From NLM Medline","DOI":"10.3390\/md15120376"},{"key":"10788_CR36","doi-asserted-by":"publisher","unstructured":"Guglielmetti S, Zanoni I, Balzaretti S, Miriani M, Taverniti V, De Noni I, Presti I, Stuknyte M, Scarafoni A, Arioli S et al.\u00a0(2014) Murein lytic enzyme TgaA of Bifidobacterium bifidum MIMBb75 modulates dendritic cell maturation through its cysteine- and histidine-dependent amidohydrolase\/peptidase (CHAP) amidase domain. Appl Environ Microbiol 80(17):5170\u20135177. https:\/\/doi.org\/10.1128\/AEM.00761-14. From NLM Medline","DOI":"10.1128\/AEM.00761-14"},{"key":"10788_CR37","doi-asserted-by":"publisher","unstructured":"Thangavelu G, Andrejeva G, Bolivar-Wagers S, Jin S, Zaiken MC, Loschi M, Aguilar EG, Furlan SN, Brown CC, Lee YC et al. (2022) Retinoic acid signaling acts as a rheostat to balance Treg function. Cell Mol Immunol 19(7):820\u2013833. https:\/\/doi.org\/10.1038\/s41423-022-00869-y. From NLM Medline","DOI":"10.1038\/s41423-022-00869-y"},{"key":"10788_CR38","doi-asserted-by":"publisher","unstructured":"Scuotto A, Romond PC, Djorie S, Alric M, Romond MB (2016) In silico mining and characterization of bifidobacterial lipoprotein with CHAP domain secreted in an aggregated form. Int J Biol Macromol 82:653\u2013662. https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.10.023. From NLM Medline","DOI":"10.1016\/j.ijbiomac.2015.10.023"},{"key":"10788_CR39","doi-asserted-by":"publisher","unstructured":"Meddings J (2008) The significance of the gut barrier in disease. Gut 57(4):438\u2013440. https:\/\/doi.org\/10.1136\/gut.2007.143172. From NLM Medline","DOI":"10.1136\/gut.2007.143172"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10788-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10788-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10788-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:59:35Z","timestamp":1778749175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10788-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10788"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10788-9","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were approved by the Animal Ethics Committee of Pharmalegacy Laboratories (Shanghai) Co., Ltd. (Approval Number: PL230912-2).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal Ethics and Consent to Publication"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}