{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:19:31Z","timestamp":1783401571199,"version":"3.54.6"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12602-025-10808-8","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:15:38Z","timestamp":1764173738000},"page":"5838-5852","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Probiotic Potential and Immunomodulatory Capacity of Lactococcus lactis NCDO 2118\u00a0Against Bacterial Pathogens and Trypanosoma cruzi"],"prefix":"10.1007","volume":"18","author":[{"given":"Mariana Oliveira","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malu Mateus Santos","family":"Obata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Obata","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamberttan Souza","family":"Desid\u00e9rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Felix","family":"Perini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weslley Guimar\u00e3es","family":"Bovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"de Oliveira Ferrato Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Sguilla","family":"Rotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Fernandes","family":"da Matta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"de Moura Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine Aparecida","family":"de Souza Benedito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Vict\u00f3ria Bernandes e","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia","family":"de Castro Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Barbosa Ferreira","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Dias","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virmondes Rodrigues","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Jos\u00e9 Freire","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helioswilton","family":"Sales-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facio Roberto Can\u00e7ado","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siomar","family":"de Castro Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Reis","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco Ariston","family":"de Carvalho Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vinicius","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"10808_CR1","doi-asserted-by":"publisher","first-page":"1000517","DOI":"10.3389\/fnut.2022.1000517","volume":"9","author":"S You","year":"2022","unstructured":"You S, Ma Y, Yan B, Pei W, Wu Q, Ding C et al (2022) The promotion mechanism of prebiotics for probiotics: a review. Front Nutr 9:1000517","journal-title":"Front Nutr"},{"issue":"1","key":"10808_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4161\/gmic.19320","volume":"3","author":"H-J Wu","year":"2012","unstructured":"Wu H-J, Wu E (2012) The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 3(1):4\u201314","journal-title":"Gut Microbes"},{"key":"10808_CR3","doi-asserted-by":"crossref","unstructured":"Khushboo, Karnwal A, Malik T (2023) Characterization and selection of probiotic lactic acid bacteria from different dietary sources for development of functional foods. Front Microbiol 14:1170725","DOI":"10.3389\/fmicb.2023.1170725"},{"issue":"8","key":"10808_CR4","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.tibtech.2017.05.002","volume":"35","author":"M Sauer","year":"2017","unstructured":"Sauer M, Russmayer H, Grabherr R, Peterbauer CK, Marx H (2017) The efficient clade: lactic acid bacteria for industrial chemical production. Trends Biotechnol 35(8):756\u2013769","journal-title":"Trends Biotechnol"},{"key":"10808_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/nu15071754","author":"Y Komano","year":"2023","unstructured":"Komano Y, Fukao K, Shimada K, Naito H, Ishihara Y, Fujii T et al (2023) Effects of ingesting food containing heat-killed Lactococcus lactis strain plasma on fatigue and immune-related indices after high training load: a randomized, double-blind, placebo-controlled, and parallel-group study. Nutrients. https:\/\/doi.org\/10.3390\/nu15071754","journal-title":"Nutrients"},{"key":"10808_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110409","volume":"129","author":"T Legesse Bedada","year":"2020","unstructured":"Legesse Bedada T, Feto TK, Awoke KS, Garedew AD, Yifat FT, Birri DJ (2020) Probiotics for cancer alternative prevention and treatment. Biomed Pharmacother 129:110409","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10808_CR7","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.ccell.2018.03.015","volume":"33","author":"V Gopalakrishnan","year":"2018","unstructured":"Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA (2018) The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell 33(4):570\u2013580","journal-title":"Cancer Cell"},{"issue":"6","key":"10808_CR8","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1097\/MOG.0b013e32834baa4d","volume":"27","author":"F Yan","year":"2011","unstructured":"Yan F, Polk DB (2011) Probiotics and immune health. Curr Opin Gastroenterol 27(6):496\u2013501","journal-title":"Curr Opin Gastroenterol"},{"issue":"1","key":"10808_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0667-9","volume":"7","author":"C van der Veer","year":"2019","unstructured":"van der Veer C, Hertzberger RY, Bruisten SM, Tytgat HLP, Swanenburg J, de Kat Angelino-Bart A et al (2019) Comparative genomics of human Lactobacillus crispatus isolates reveals genes for glycosylation and glycogen degradation: implications for in vivo dominance of the vaginal microbiota. Microbiome 7(1):49","journal-title":"Microbiome"},{"issue":"2","key":"10808_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ijfoodmicro.2004.04.015","volume":"97","author":"V Coeuret","year":"2004","unstructured":"Coeuret V, Gueguen M, Vernoux JP (2004) Numbers and strains of lactobacilli in some probiotic products. Int J Food Microbiol 97(2):147\u2013156","journal-title":"Int J Food Microbiol"},{"issue":"3","key":"10808_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ijfoodmicro.2005.03.008","volume":"105","author":"S Mathur","year":"2005","unstructured":"Mathur S, Singh R (2005) Antibiotic resistance in food lactic acid bacteria\u2013a review. Int J Food Microbiol 105(3):281\u2013295","journal-title":"Int J Food Microbiol"},{"issue":"11","key":"10808_CR12","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1110\/ps.041032204","volume":"13","author":"H Von D\u00f6hren","year":"2004","unstructured":"Von D\u00f6hren H (2004) Antibiotics: actions, origins, resistance, by C. walsh. 2003. Washington, DC: ASM press. 345 pp. $99.95 (hardcover). Protein Sci 13(11):3059\u20133060. https:\/\/doi.org\/10.1110\/ps.041032204","journal-title":"Protein Sci"},{"key":"10808_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081984","author":"HS Lim","year":"2018","unstructured":"Lim HS, Yeu JE, Hong SP, Kang MS (2018) Characterization of antibacterial cell-free supernatant from oral care probiotic Weissella cibaria, CMU. Molecules. https:\/\/doi.org\/10.3390\/molecules23081984","journal-title":"Molecules"},{"key":"10808_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194673","author":"CAM Wegh","year":"2019","unstructured":"Wegh CAM, Geerlings SY, Knol J, Roeselers G, Belzer C (2019) Postbiotics and their potential applications in early life nutrition and beyond. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20194673","journal-title":"Int J Mol Sci"},{"key":"10808_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1756308","volume":"2018","author":"S De Marco","year":"2018","unstructured":"De Marco S, Sichetti M, Muradyan D, Piccioni M, Traina G, Pagiotti R (2018) Probiotic cell-free supernatants exhibited anti-inflammatory and antioxidant activity on human gut epithelial cells and macrophages stimulated with LPS. Evidence-Based Complementary and Alternative Medicine 2018:1756308","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"10808_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020419","author":"A Barrientos-Dur\u00e1n","year":"2020","unstructured":"Barrientos-Dur\u00e1n A, Fuentes-L\u00f3pez A, de Salazar A, Plaza-D\u00edaz J, Garc\u00eda F (2020) Reviewing the composition of vaginal microbiota: inclusion of nutrition and probiotic factors in the maintenance of eubiosis. Nutrients. https:\/\/doi.org\/10.3390\/nu12020419","journal-title":"Nutrients"},{"issue":"10","key":"10808_CR17","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.4014\/jmb.1503.03033","volume":"25","author":"KJ Han","year":"2015","unstructured":"Han KJ, Lee NK, Park H, Paik HD (2015) Anticancer and anti-inflammatory activity of probiotic Lactococcus lactis NK34. J Microbiol Biotechnol 25(10):1697\u20131701","journal-title":"J Microbiol Biotechnol"},{"issue":"2","key":"10808_CR18","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00253-021-11646-8","volume":"106","author":"MK Yadav","year":"2022","unstructured":"Yadav MK, Kumari I, Singh B, Sharma KK, Tiwari SK (2022) Probiotics, prebiotics and synbiotics: safe options for next-generation therapeutics. Appl Microbiol Biotechnol 106(2):505\u2013521","journal-title":"Appl Microbiol Biotechnol"},{"key":"10808_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.585857","author":"E Duarte-Silva","year":"2020","unstructured":"Duarte-Silva E, Morais LH, Clarke G, Savino W, Peixoto C (2020) Targeting the gut microbiota in Chagas disease: what do we know so far? Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2020.585857","journal-title":"Front Microbiol"},{"issue":"1","key":"10808_CR20","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1128\/AAC.01401-12","volume":"57","author":"MJ Pinazo","year":"2013","unstructured":"Pinazo MJ, Guerrero L, Posada E, Rodr\u00edguez E, Soy D (2013) Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease. Antimicrob Agents Chemother 57(1):390\u2013395 (Gascon J)","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10808_CR21","doi-asserted-by":"publisher","first-page":"371","DOI":"10.15585\/mmwr.mm7110a2","volume":"71","author":"A Abbott","year":"2022","unstructured":"Abbott A, Montgomery SP, Chancey RJ (2022) Characteristics and adverse events of patients for whom Nifurtimox was released through CDC-sponsored investigational new drug program for treatment of Chagas disease - United States, 2001\u20132021. MMWR Morb Mortal Wkly Rep 71(10):371\u2013374","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10808_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00759","volume":"10","author":"W Marques Da Silva","year":"2019","unstructured":"Marques Da Silva W, Oliveira LC, Soares SC, Sousa CS, Tavares GC, Resende CP et al (2019) Quantitative proteomic analysis of the response of probiotic putative Lactococcus lactis NCDO 2118 strain to different oxygen availability under temperature variation. Front Microbiol 10:759","journal-title":"Front Microbiol"},{"issue":"3","key":"10808_CR23","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.pt.2016.11.003","volume":"33","author":"A Hefnawy","year":"2017","unstructured":"Hefnawy A, Berg M, Dujardin JC, De Muylder G (2017) Exploiting knowledge on Leishmania drug resistance to support the quest for new drugs. Trends Parasitol 33(3):162\u2013174","journal-title":"Trends Parasitol"},{"key":"10808_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2024.107065","volume":"197","author":"HF Perini","year":"2024","unstructured":"Perini HF, Pereira BdB, Sousa EG, Matos BS, Silva Prado LCd, Carvalho Azevedo VAd et al (2024) Inhibitory effect of Bacillus velezensis 1273 strain cell-free supernatant against developing and preformed biofilms of Staphylococcus aureus and MRSA. Microb Pathog 197:107065","journal-title":"Microb Pathog"},{"issue":"3","key":"10808_CR25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0309-1740(99)00156-4","volume":"55","author":"S Erkkil\u00e4","year":"2000","unstructured":"Erkkil\u00e4 S, Pet\u00e4j\u00e4 E (2000) Screening of commercial meat starter cultures at low pH and in the presence of bile salts for potential probiotic use. Meat Sci 55(3):297\u2013300","journal-title":"Meat Sci"},{"issue":"2","key":"10808_CR26","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.meatsci.2003.11.003","volume":"67","author":"C Pennacchia","year":"2004","unstructured":"Pennacchia C, Ercolini D, Blaiotta G, Pepe O, Mauriello G, Villani F (2004) Selection of Lactobacillus strains from fermented sausages for their potential use as probiotics. Meat Sci 67(2):309\u2013317","journal-title":"Meat Sci"},{"key":"10808_CR27","first-page":"798","volume-title":"Handbook of probiotics and prebiotics","author":"YK Lee","year":"2009","unstructured":"Lee YK, Salminen S (2009) Handbook of probiotics and prebiotics, 2nd edn. John Wiley & Sons, Hoboken (NJ), p 798","edition":"2"},{"issue":"7","key":"10808_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-019-2675-0","volume":"35","author":"KR Rocha","year":"2019","unstructured":"Rocha KR, Perini HF, de Souza CM, Schueler J, Tosoni NF, Furlaneto MC et al (2019) Inhibitory effect of bacteriocins from enterococci on developing and preformed biofilms of Listeria monocytogenes, Listeria ivanovii and Listeria innocua. World J Microbiol Biotechnol 35(7):96","journal-title":"World J Microbiol Biotechnol"},{"key":"10808_CR29","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2015) Performance standards for antimicrobial susceptibility testing: twenty-fifth informational supplement. CLSI document M100-S25. CLSI,\u00a0Wayne, PA"},{"issue":"2","key":"10808_CR30","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s12602-019-09536-7","volume":"12","author":"P Dowdell","year":"2020","unstructured":"Dowdell P, Chankhamhaengdecha S, Panbangred W, Janvilisri T, Aroonnual A (2020) Probiotic activity of Enterococcus faecium and Lactococcus lactis isolated from Thai fermented sausages and their protective effect against Clostridium difficile. Probiotics Antimicrob Proteins 12(2):641\u2013648","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10808_CR31","doi-asserted-by":"crossref","unstructured":"Ammerman NC, Beier-Sexton M, Azad AF (2008) Growth and maintenance of Vero cell lines. Curr Protoc Microbiol. Appendix 4:Appendix 4E","DOI":"10.1002\/9780471729259.mca04es11"},{"key":"10808_CR32","first-page":"1","volume":"1","author":"K Khalid","year":"2011","unstructured":"Khalid K (2011) An overview of lactic acid bacteria. Int J Biosci 1:1\u201313","journal-title":"Int J Biosci"},{"issue":"4","key":"10808_CR33","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/ibd.21834","volume":"18","author":"C Santos Rocha","year":"2012","unstructured":"Santos Rocha C, Lakhdari O, Blotti\u00e8re HM, Blugeon S, Sokol H, Berm\u00fadez-Humar\u00e1n LG et al (2012) Anti-inflammatory properties of dairy lactobacilli. Inflamm Bowel Dis 18(4):657\u2013666","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"10808_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175116","volume":"12","author":"LC Oliveira","year":"2017","unstructured":"Oliveira LC, Saraiva TD, Silva WM, Pereira UP, Campos BC, Benevides LJ et al (2017) Analyses of the probiotic property and stress resistance-related genes of Lactococcus lactis subsp. lactis NCDO 2118 through comparative genomics and in vitro assays. PLoS ONE 12(4):e0175116","journal-title":"PLoS ONE"},{"issue":"9","key":"10808_CR35","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0963-9969(03)00098-X","volume":"36","author":"CG Vinderola","year":"2003","unstructured":"Vinderola CG, Reinheimer JA (2003) Lactic acid starter and probiotic bacteria: a comparative \u201cin vitro\u201d study of probiotic characteristics and biological barrier resistance. Food Res Int 36(9):895\u2013904","journal-title":"Food Res Int"},{"key":"10808_CR36","doi-asserted-by":"publisher","unstructured":"Tang T, Leisner JJ (2024) Bacteriocin antagonistic potentials of Lactococcus cremoris and Lactococcus lactis isolates from different habitats. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-024-10361-w","DOI":"10.1007\/s12602-024-10361-w"},{"issue":"1","key":"10808_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34586-x","volume":"13","author":"C O\u2019Reilly","year":"2023","unstructured":"O\u2019Reilly C, Grimaud GM, Coakley M, O\u2019Connor PM, Mathur H, Peterson VL et al (2023) Modulation of the gut microbiome with nisin. Sci Rep 13(1):7899","journal-title":"Sci Rep"},{"issue":"1","key":"10808_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-020-01426-w","volume":"19","author":"BH Nataraj","year":"2020","unstructured":"Nataraj BH, Ali SA, Behare PV, Yadav H (2020) Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods. Microb Cell Fact 19(1):168","journal-title":"Microb Cell Fact"},{"issue":"1","key":"10808_CR39","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1046\/j.1440-1711.2000.00886.x","volume":"78","author":"K Kailasapathy","year":"2000","unstructured":"Kailasapathy K, Chin J (2000) Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Immunol Cell Biol 78(1):80\u201388","journal-title":"Immunol Cell Biol"},{"issue":"8","key":"10808_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237754","volume":"15","author":"T Yamazaki","year":"2020","unstructured":"Yamazaki T, Ohshio K, Sugamata M, Morita Y (2020) Lactic acid bacterium, Lactobacillus paracasei KW3110, suppresses inflammatory stress-induced caspase-1 activation by promoting interleukin-10 production in mouse and human immune cells. PLoS ONE 15(8):e0237754","journal-title":"PLoS ONE"},{"issue":"3","key":"10808_CR41","first-page":"220","volume":"13","author":"M Karamese","year":"2016","unstructured":"Karamese M, Aydin H, Sengul E, Gelen V, Sevim C, Ustek D et al (2016) The Immunostimulatory Effect of Lactic Acid Bacteria in a Rat Model. Iranian journal of immunology\u202f: IJI 13(3):220\u2013228","journal-title":"Iranian journal of immunology : IJI"},{"issue":"8","key":"10808_CR42","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.ijmm.2015.07.005","volume":"305","author":"A Rizzo","year":"2015","unstructured":"Rizzo A, Fiorentino M, Buommino E, Donnarumma G, Losacco A, Bevilacqua N (2015) Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro. Int J Med Microbiol 305(8):815\u2013827","journal-title":"Int J Med Microbiol"},{"issue":"1","key":"10808_CR43","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.intimp.2014.04.021","volume":"21","author":"SE Jang","year":"2014","unstructured":"Jang SE, Han MJ, Kim SY, Kim DH (2014) Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages. Int Immunopharmacol 21(1):186\u2013192","journal-title":"Int Immunopharmacol"},{"key":"10808_CR44","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.copbio.2017.05.006","volume":"47","author":"GA Kim","year":"2017","unstructured":"Kim GA, Spence JR, Takayama S (2017) Bioengineering for intestinal organoid cultures. Curr Opin Biotechnol 47:51\u201358","journal-title":"Curr Opin Biotechnol"},{"key":"10808_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-6-33","volume":"6","author":"TD Luerce","year":"2014","unstructured":"Luerce TD, Gomes-Santos AC, Rocha CS, Moreira TG, Cruz DN, Lemos L et al (2014) Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis. Gut Pathog 6:33","journal-title":"Gut Pathog"},{"issue":"3","key":"10808_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032728","volume":"7","author":"WA Rose 2nd","year":"2012","unstructured":"Rose WA 2nd, McGowin CL, Spagnuolo RA, Eaves-Pyles TD, Popov VL, Pyles RB (2012) Commensal bacteria modulate innate immune responses of vaginal epithelial cell multilayer cultures. PLoS ONE 7(3):e32728","journal-title":"PLoS ONE"},{"key":"10808_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010184","author":"C Mazziotta","year":"2023","unstructured":"Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC (2023) Probiotics mechanism of action on immune cells and beneficial effects on human health. Cells. https:\/\/doi.org\/10.3390\/cells12010184","journal-title":"Cells"},{"key":"10808_CR48","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8063647","volume":"2018","author":"MAK Azad","year":"2018","unstructured":"Azad MAK, Sarker M, Wan D (2018) Immunomodulatory effects of probiotics on cytokine profiles. BioMed Res Int 2018:8063647","journal-title":"BioMed Res Int"},{"issue":"1","key":"10808_CR49","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5114\/bta.2023.125085","volume":"104","author":"BO Oladejo","year":"2023","unstructured":"Oladejo BO, Adeboboye CF, Adiji PI, Adebolu TT (2023) Cytokine-mediated immunoregulatory activity of Lactobacillus species in a carrageenan-induced acute inflammatory model. Biotechnologia 104(1):53\u201363","journal-title":"Biotechnologia"},{"key":"10808_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.578386","volume":"12","author":"F Cristofori","year":"2021","unstructured":"Cristofori F, Dargenio VN, Dargenio C, Miniello VL, Barone M, Francavilla R (2021) Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body. Front Immunol 12:578386","journal-title":"Front Immunol"},{"key":"10808_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03063","volume":"9","author":"R Ayyanna","year":"2018","unstructured":"Ayyanna R, Ankaiah D, Arul V (2018) Anti-inflammatory and antioxidant properties of probiotic bacterium Lactobacillus mucosae AN1 and Lactobacillus fermentum SNR1 in Wistar Albino rats. Front Microbiol 9:3063","journal-title":"Front Microbiol"},{"issue":"4","key":"10808_CR52","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1111\/jcmm.14195","volume":"23","author":"M Jin","year":"2019","unstructured":"Jin M, Qian Z, Yin J, Xu W, Zhou X (2019) The role of intestinal microbiota in cardiovascular disease. J Cell Mol Med 23(4):2343\u20132350","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10808_CR53","doi-asserted-by":"publisher","first-page":"638","DOI":"10.4014\/jmb.2201.01015","volume":"32","author":"HJ Noh","year":"2022","unstructured":"Noh HJ, Park JM, Kwon YJ, Kim K, Park SY, Kim I et al (2022) Immunostimulatory effect of heat-killed probiotics on RAW264.7 macrophages. J Microbiol Biotechnol 32(5):638\u2013644","journal-title":"J Microbiol Biotechnol"},{"key":"10808_CR54","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1196\/annals.1428.037","volume":"1149","author":"CR Bautista","year":"2008","unstructured":"Bautista CR, Sandoval A, Aguilar BR (2008) Effect of high- and low-molecular-weight components of Lactobacillus casei on resistance against Babesia microti in NIH mice. Ann N Y Acad Sci 1149:152\u2013154","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"10808_CR55","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1128\/CVI.13.2.219-226.2006","volume":"13","author":"CM Galdeano","year":"2006","unstructured":"Galdeano CM, Perdig\u00f3n G (2006) The probiotic bacterium Lactobacillus casei induces activation of the gut mucosal immune system through innate immunity. Clin Vaccine Immunol 13(2):219\u2013226","journal-title":"Clin Vaccine Immunol"},{"issue":"9","key":"10808_CR56","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.4049\/jimmunol.173.9.5688","volume":"173","author":"AC Oliveira","year":"2004","unstructured":"Oliveira AC, Peixoto JR, de Arruda LB, Campos MA, Gazzinelli RT, Golenbock DT et al (2004) Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 173(9):5688\u20135696","journal-title":"J Immunol"},{"key":"10808_CR57","doi-asserted-by":"crossref","unstructured":"Martinez FO, Gordon S (2014) The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 6:13","DOI":"10.12703\/P6-13"},{"issue":"2","key":"10808_CR58","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00430-021-00703-8","volume":"210","author":"MN Rostami","year":"2021","unstructured":"Rostami MN, Khamesipour A (2021) Potential biomarkers of immune protection in human leishmaniasis. Med Microbiol Immunol 210(2):81\u2013100","journal-title":"Med Microbiol Immunol"},{"key":"10808_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1244071","volume":"14","author":"NS Vellozo","year":"2023","unstructured":"Vellozo NS, Matos-Silva TC, Lopes MF (2023) Immunopathogenesis in Trypanosoma cruzi infection: a role for suppressed macrophages and apoptotic cells. Front Immunol 14:1244071","journal-title":"Front Immunol"},{"key":"10808_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00670","volume":"10","author":"A Dayakar","year":"2019","unstructured":"Dayakar A, Chandrasekaran S, Kuchipudi SV, Kalangi SK (2019) Cytokines: key determinants of resistance or disease progression in visceral leishmaniasis: opportunities for novel diagnostics and immunotherapy. Front Immunol 10:670","journal-title":"Front Immunol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10808-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10808-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10808-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:06:56Z","timestamp":1783400816000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10808-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10808"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10808-8","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"6 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}