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Prot."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Data analysing the impact of probiotics in preventing the occurrence of acute diverticulitis (AD) in patients having symptomatic uncomplicated diverticular disease (SUDD) of the colon are still scarce. We assessed the effectiveness of\n                    <jats:italic>Lactobacillus paracasei<\/jats:italic>\n                    \u00a0CNCM I 1572 in preventing the first episode of AD in patients with SUDD. A post-hoc analysis of a 12-month, multicentre, double-blind, placebo-controlled study was conducted. One hundred and five patients were randomly enrolled in a double-blind fashion into Group L (\n                    <jats:italic>Lactobacillus paracasei<\/jats:italic>\n                    \u00a0\n                    <jats:italic>CNCM I 1572<\/jats:italic>\n                    , 24 billion CFU\/day) and Group P (placebo). Patients received treatment for 10\u00a0days per month for 12\u00a0months. The occurrence of AD was defined according to radiological criteria from abdominal computerised tomography. AD occurred in 7 of the analysed patients during follow-up: 6 patients were in group P and one patient in group L (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036). AD was uncomplicated in 6 out of 7 patients, while one patient receiving placebo underwent surgery due to free perforation. During the follow-up, mild adverse events (7.27% in group L and 9.0% in group P,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.90) were recorded and did not necessitate treatment discontinuation.\n                    <jats:italic>Lactobacillus paracasei<\/jats:italic>\n                    \u00a0CNCM I 1572 appears to be more effective than placebo in preventing the first episode of AD in SUDD patients. It could therefore be a real chance for the prevention of this diverticular disease complication. We need more data from prospective placebo-controlled trials enrolling a large population of patients to confirm this finding.\n                  <\/jats:p>","DOI":"10.1007\/s12602-025-10812-y","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:07:18Z","timestamp":1760702838000},"page":"4738-4745","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lactobacillus Paracasei CNCM I 1572 is Better than Placebo in Preventing Acute Diverticulitis Occurrence (Revised Manuscript 661a120f-b910-4133-ab7e-4bd3e1713c96)"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-5541","authenticated-orcid":false,"given":"Antonio","family":"Tursi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-8240","authenticated-orcid":false,"given":"Marcello","family":"Picchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-0194","authenticated-orcid":false,"given":"Walter","family":"Elisei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Brandimarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di Mario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-1351","authenticated-orcid":false,"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-7298","authenticated-orcid":false,"given":"Alfredo","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"10812_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41572-020-0153-5","volume":"6","author":"A Tursi","year":"2020","unstructured":"Tursi A, Scarpignato C, Strate LL, Lanas A, Kruis W, Lahat A, Danese S (2020) Colonic diverticular disease. 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Br J Gen Pract 64:595. https:\/\/doi.org\/10.3399\/bjgp14X682525","journal-title":"Br J Gen Pract"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10812-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10812-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10812-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:57:49Z","timestamp":1778749069000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10812-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10812"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10812-y","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"30 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the World Medical Association Declaration of Helsinki (1975). It was approved by the Ethics Committee of the coordinating centre\u00a0and all participating centres. The study was recorded at\n                      \n                      (NCT01534754).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All study participants provided informed written consent before undergoing endoscopic investigation and participating in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patients Consent"}},{"value":"Antonio Tursi served as speaker and\/or consultant for AbbVie, Bayer, Fenix Pharma, Gal\u00e1pagos, Janssen, Nalkein, Omega Pharma, and Sila;  Alfredo Papa served as a speaker for AlfaSigma and Janssen;  Silvio Danese served as speaker, consultant, and\/or advisory board member for AbbVie, Allergan, Alfa Wassermann, Biogen, Boehringer Ingelheim, Celgene, Celltrion, Ferring, Gilead, Hospira, Johnson & Johnson, Merck, MSD, Mundipharma, Pfizer Inc., Sandoz, Takeda, Tigenix, UCB Pharma, and Vifor.   The remaining authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}