{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:49:11Z","timestamp":1785898151907,"version":"3.56.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82203031 to Y.L."],"award-info":[{"award-number":["82203031 to Y.L."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["BK20220375 to Y.L."],"award-info":[{"award-number":["BK20220375 to Y.L."]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12602-025-10818-6","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:36:20Z","timestamp":1762162580000},"page":"4954-4968","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multi-Strain Probiotics Alleviate Alcoholic Liver Disease Via Microbiota\u2013Metabolism Axis: A Randomized Controlled Study"],"prefix":"10.1007","volume":"18","author":[{"given":"Jiaying","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"issue":"6","key":"10818_CR1","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1097\/HEP.0000000000000899","volume":"80","author":"F Aberg","year":"2024","unstructured":"Aberg F, Jiang ZG, Cortez-Pinto H, Mannisto V (2024) Alcohol-associated liver disease-global epidemiology. Hepatology 80(6):1307\u20131322","journal-title":"Hepatology"},{"issue":"1","key":"10818_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0014-7","volume":"4","author":"HK Seitz","year":"2018","unstructured":"Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H (2018) Alcoholic liver disease. Nat Rev Dis Primers 4(1):16","journal-title":"Nat Rev Dis Primers"},{"key":"10818_CR3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-077090","volume":"383","author":"M Thursz","year":"2023","unstructured":"Thursz M, Lingford-Hughes A (2023) Advances in the understanding and management of alcohol-related liver disease. BMJ 383:e077090","journal-title":"BMJ"},{"key":"10818_CR4","doi-asserted-by":"crossref","unstructured":"Bj\u00f8rkhaug ST, Aanes H, Prasad S, J\u00f8rgen N (2019) Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption. Gut Microbes 10(6):663\u2013675","DOI":"10.1080\/19490976.2019.1580097"},{"issue":"12","key":"10818_CR5","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nrgastro.2017.152","volume":"14","author":"K Ray","year":"2017","unstructured":"Ray K (2017) Alcoholic liver disease: gut-liver axis: PPIs, Enterococcus and promotion of alcoholic liver disease. Nat Rev Gastroenterol Hepatol 14(12):689","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10818_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","volume":"16","author":"JS Bajaj","year":"2019","unstructured":"Bajaj JS (2019) Alcohol, liver disease and the gut microbiota. Nat Rev Gastroenterol Hepatol 16:235\u2013246","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"10818_CR7","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","volume":"141","author":"B Gao","year":"2011","unstructured":"Gao B, Bataller R (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141(5):1572\u20131585","journal-title":"Gastroenterology"},{"issue":"1","key":"10818_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04166-8","volume":"21","author":"C Yan","year":"2023","unstructured":"Yan C, Hu W, Tu J, Li J, Liang QL, Han S (2023) Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. J Transl Med 21(1):300","journal-title":"J Transl Med"},{"issue":"1","key":"10818_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/biom7010009","volume":"7","author":"F Magdaleno","year":"2017","unstructured":"Magdaleno F, Blajszczak CC, Nieto N (2017) Key events participating in the pathogenesis of alcoholic liver disease. Biomolecules 7(1):9","journal-title":"Biomolecules"},{"issue":"1","key":"10818_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-014-0240-4","volume":"14","author":"MCC Canesso","year":"2014","unstructured":"Canesso MCC, Lacerda NL, Ferreira CM, Gon\u00e7alves JL, Almeida D, Gamba C, Cassali G, Pedroso SH, Moreira C, Martins FS, Nicoli JR, Teixeira MM, Godard ALB, Vieira AT (2014) Comparing the effects of acute alcohol consumption in germ-free and conventional mice: the role of the gut microbiota. BMC Microbiol 14(1):240","journal-title":"BMC Microbiol"},{"issue":"5","key":"10818_CR11","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","volume":"67","author":"G Christoph","year":"2018","unstructured":"Christoph G, Verena EAT, Patrick W, Laura L, Benedek W, V W D G, Felix G, Alexandra RGR, Barbara P, Dragos E, Sophie C, Lisa M, Matthias M, Patrizia D, Gabriel MRMA, Gyongyi P, Marie S, Herbert CA T (2018) Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease. Gut 67(5):891\u2013901","journal-title":"Gut"},{"key":"10818_CR12","volume":"8","author":"L Yue","year":"2022","unstructured":"Yue L, Jiaqi W, Changxin W (2022) Modulation of gut microbiota and immune system by probiotics, pre-biotics, and post-biotics. Front Nutr 8:634897\u2013634897","journal-title":"Front Nutr"},{"issue":"2","key":"10818_CR13","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/nu17020320","volume":"17","author":"J Zhang","year":"2025","unstructured":"Zhang J, Li C, Duan M, Qu Z, Wang Y, Dong Y, Wu Y, Fang S, Gu S (2025) The improvement effects of Weizmannia coagulans BC99 on liver function and gut microbiota of Long-Term alcohol drinkers: a randomized Double-Blind clinical trial. Nutrients 17(2):320\u2013320","journal-title":"Nutrients"},{"issue":"1","key":"10818_CR14","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3390\/antiox14010117","volume":"14","author":"Y Wu","year":"2025","unstructured":"Wu Y, Li C, Gao Y, Zhang J, Dong Y, Zhao L, Li Y, Gu S (2025) Weizmannia coagulans BC99 attenuates oxidative stress induced by acute alcoholic liver injury via Nrf2\/SKN-1 pathway and liver metabolism regulation. Antioxidants 14(1):117\u2013117","journal-title":"Antioxidants"},{"key":"10818_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2025.106752","volume":"127","author":"Z Wan","year":"2025","unstructured":"Wan Z, Zhang J, Cui F, Li X, Zhang Z, Meng J, Zhang M (2025) The effect of Lacticaseibacillus rhamnosus LRa05 probiotic tablets on the immune function of mice and its safety. J Funct Foods 127:106752\u2013106752","journal-title":"J Funct Foods"},{"issue":"8","key":"10818_CR16","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.tim.2021.03.010","volume":"29","author":"IPM Gregor","year":"2021","unstructured":"Gregor IPM, A T H R J (2021) Lacticaseibacillus rhamnosus GR-1, a.k.a. Lactobacillus rhamnosus GR-1: past and future perspectives. Trends Microbiol 29(8):747\u2013761","journal-title":"Trends Microbiol"},{"key":"10818_CR17","volume":"10","author":"G Zhonghui","year":"2023","unstructured":"Zhonghui G, Yao D, Fei X, Junli Z, Yujiao Y, Yuwen W (2023) Changes in the gut microbiota composition of healthy young volunteers after administration of Lacticaseibacillus rhamnosus LRa05: a placebo-controlled study. Front Nutr 10:1105694\u20131105694","journal-title":"Front Nutr"},{"issue":"1","key":"10818_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13568-022-01411-z","volume":"12","author":"D Yao","year":"2022","unstructured":"Yao D, Wenyan L, Jing T, Teng F, Zhonghui G, Mei H (2022) Bifidobacterium BLa80 mitigates colitis by altering gut microbiota and alleviating inflammation. AMB Express 12(1):67\u201367","journal-title":"AMB Express"},{"issue":"2","key":"10818_CR19","first-page":"1749","volume":"32","author":"X Peng","year":"2023","unstructured":"Peng X, Kuopeng C, Liming C, Shaoshu C, Zheng W (2023) Effect of dietary bifidobacterium animalis subsp. lactis BLa80 on growth, immune response, antioxidant capacity, and intestinal microbiota of juvenile Japanese seabass (Lateolabrax japonicus). Aquacult Int 32(2):1749\u20131769","journal-title":"Aquacult Int"},{"issue":"2","key":"10818_CR20","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.3390\/ijms24021502","volume":"24","author":"Z Jiayuan","year":"2023","unstructured":"Jiayuan Z, Xiaoling Z, Jinxiao L, Yicong Z, Zhihua L, Mingming Y (2023) Changes in lipidomics, metabolomics, and the gut microbiota in CDAA-induced NAFLD mice after polyene phosphatidylcholine treatment. Int J Mol Sci 24(2):1502\u20131502","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10818_CR21","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/biof.1495","volume":"45","author":"Y Haining","year":"2019","unstructured":"Haining Y, Zhen Y, Haiyong H, Peng L, Qiu T, Xique W, Shengrong S (2019) Gut microbiota signatures and lipids metabolism profiles by exposure to polyene phosphatidylcholine. Biofactors 45(3):439\u2013449","journal-title":"Biofactors"},{"issue":"16","key":"10818_CR22","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.3390\/cells11162617","volume":"11","author":"dV Raffaella","year":"2022","unstructured":"Raffaella dV, Carmela C, Giovanna T (2022) A Multi-Strain probiotic formulation improves intestinal barrier function by the modulation of tight and adherent junction proteins. Cells 11(16):2617\u20132617","journal-title":"Cells"},{"issue":"4","key":"10818_CR23","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3390\/biology10040322","volume":"10","author":"AAO D. K I","year":"2021","unstructured":"D. K I AAO, Moses O, A. A M (2021) Multi-Strain probiotics: synergy among isolates enhances biological activities. Biology 10(4):322\u2013322","journal-title":"Biology"},{"issue":"4","key":"10818_CR24","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/MOL.0000000000000426","volume":"28","author":"SR Aj","year":"2017","unstructured":"Aj SR, Wouter JJ, Stella T (2017) Increasing HDL-C levels with medication: current perspectives. Curr Opin Lipidol 28(4):361\u2013366","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"10818_CR25","first-page":"21","volume":"13","author":"KSM Jeewon","year":"2021","unstructured":"Jeewon KSM, Nicholas G, Julia J, Surabhi M, Madeleine T, Orville NJMP, John KE (2021) Butyrate-producing human gut symbiont, clostridium butyricum, and its role in health and disease. Gut Microbes 13(1):21\u201328","journal-title":"Gut Microbes"},{"issue":"3","key":"10818_CR26","volume":"6","author":"W Lifu","year":"2021","unstructured":"Lifu W, Yao L, Ruibing Y, Zifeng Z, Lichao Z, Zhongdao W, Xi S (2021) An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae\/butyrate\/retinoic acid axis. Bioeng Transl Med 6(3):e10219\u2013e10219","journal-title":"Bioeng Transl Med"},{"issue":"4","key":"10818_CR27","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1158\/1078-0432.CCR-23-0195","volume":"30","author":"R Alba","year":"2024","unstructured":"Alba R, Andr\u00e9s A, Roberto G, Luz MM, Rub\u00e9n G, Pablo J, Clara C, Jose S, Nieves L, Rafael A, Noemi P, MariaVictoria M, Rosa A, Dulcenombre G, Joaquin M, Mar\u00eda L (2024) Short-chain fatty acid production by gut microbiota predicts treatment response in multiple myeloma. Clin Cancer Research: Official J Am Association Cancer Res 30(4):904\u2013917","journal-title":"Clin Cancer Research: Official J Am Association Cancer Res"},{"issue":"6","key":"10818_CR28","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1159\/000522247","volume":"40","author":"F Howard","year":"2022","unstructured":"Howard F (2022) The role of Faecalibacterium, Roseburia and butyrate in inflammatory bowel disease. Digestive diseases (Basel. Switzerland) 40(6):793\u2013795","journal-title":"Digestive diseases (Basel. Switzerland)"},{"issue":"12","key":"10818_CR29","doi-asserted-by":"publisher","first-page":"102026","DOI":"10.1016\/j.cdnut.2023.102026","volume":"7","author":"A Raz","year":"2023","unstructured":"Raz A, Jessica E, Rana A-S (2023) Role of bifidobacterium in modulating the intestinal epithelial tight junction barrier: current knowledge and perspectives. Curr Developments Nutr 7(12):102026","journal-title":"Curr Developments Nutr"},{"key":"10818_CR30","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nature13823","volume":"514","author":"JM Pickard","year":"2014","unstructured":"Pickard JM, Maurice CF, Kinnebrew MA, Abt MC, Schenten D, Golovkina TV, Bogatyrev SR, Ismagilov RF, Pamer EG, Turnbaugh PJ (2014) Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature 514:638\u2013641","journal-title":"Nature"},{"issue":"4","key":"10818_CR31","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1172\/JCI45538","volume":"121","author":"F Jianxin","year":"2011","unstructured":"Jianxin F, Bo W, Tao W, Xiaowei EVJM, Emily L, Samuel BATK, Lilah M, Maomeng M, Michael T, S T MJJ, Hong RTJ, Jonathan CCHG, Lijun B X (2011) Loss of intestinal core 1\u2013derived O-glycans causes spontaneous colitis in mice. J Clin Invest 121(4):1657\u20131666","journal-title":"J Clin Invest"},{"issue":"4","key":"10818_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2021.04.010","volume":"10","author":"J Hao","year":"2021","unstructured":"Hao J, Ye L, Meng G, Song Y, Fu J, Wu X (2021) The protective effect and crucial biological pathways analysis of trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics. Food Sci Hum Wellness 10(4):10","journal-title":"Food Sci Hum Wellness"},{"issue":"3","key":"10818_CR33","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.jid.2020.07.017","volume":"141","author":"PH Hart","year":"2020","unstructured":"Hart PH, Norval M (2020) The multiple roles of urocanic acid in health and disease. J Invest Dermatol 141(3):496\u2013502","journal-title":"J Invest Dermatol"},{"issue":"11","key":"10818_CR34","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.3390\/nu13114120","volume":"13","author":"L Ling","year":"2021","unstructured":"Ling L, Li Z, An L, Dongyin Y, Yingqi P, Sheng Z, Yinhua L, Jinhua C, Wenjun X, Zhihua G (2021) Role of Epigallocatechin gallate in Glucose, Lipid, and protein metabolism and L-Theanine in the metabolism-Regulatory effects of Epigallocatechin gallate. Nutrients 13(11):4120\u20134120","journal-title":"Nutrients"},{"key":"10818_CR35","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.foodchem.2018.09.120","volume":"275","author":"J Xiang","year":"2018","unstructured":"Xiang J, Apea-Bah FB, Ndolo VU, Katundu MC, Beta T (2018) Profile of phenolic compounds and antioxidant activity of finger millet varieties. Food Chem 275:361\u2013368","journal-title":"Food Chem"},{"issue":"1","key":"10818_CR36","doi-asserted-by":"publisher","first-page":"15676","DOI":"10.1038\/s41598-025-99944-3","volume":"15","author":"T Urbanowicz","year":"2025","unstructured":"Urbanowicz T, Gutaj P, Plewa S, Spasenenko I, Wi\u015bniewska AO, Krasi\u0144ska B, Tykarski A, Plachta AK, Szcze\u015bniak \u0141P, Krasi\u0144ski Z, Grywalska E, Rahnama M, Matysiak J, O\u017cegowska EW (2025) Obesity and acylcarnitine derivates interplay with coronary artery disease. Sci Rep 15(1):15676\u201315676","journal-title":"Sci Rep"},{"issue":"1","key":"10818_CR37","first-page":"11","volume":"80","author":"M Camille","year":"2020","unstructured":"Camille M, Ludovica M, Pierre MBH, Nicolas L (2020) L SCFA: mechanisms and functional importance in the gut. Proc Nutr Soc 80(1):11\u201313","journal-title":"Proc Nutr Soc"},{"issue":"2","key":"10818_CR38","first-page":"361","volume":"151","author":"TJ Kai","year":"2022","unstructured":"Kai TJ, Laurence M, R M C (2022) Dietary fiber and SCFAs in the regulation of mucosal immunity. J Allergy Clin Immunol 151(2):361\u2013370","journal-title":"J Allergy Clin Immunol"},{"key":"10818_CR39","doi-asserted-by":"crossref","unstructured":"Xiong SY, Wu GS, Li C, Ma W, Luo HR (2024) Clinical efficacy of probiotics in the treatment of alcoholic liver disease: a systematic review and meta-analysis. Front Cell Infect Microbiol 14:1358063","DOI":"10.3389\/fcimb.2024.1358063"},{"issue":"4","key":"10818_CR40","volume":"102","author":"Z Xiangyu","year":"2023","unstructured":"Xiangyu Z, Jincheng W, Sufang Z, Jiajia L, Zuoyu Y, Leiming M (2023) Efficacy of probiotics on nonalcoholic fatty liver disease: a meta-analysis. Medicine (Baltimore) 102(4):e32734\u2013e32734","journal-title":"Medicine (Baltimore)"},{"key":"10818_CR41","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.70074","author":"K Huang","year":"2025","unstructured":"Huang K, Ma L, Shi S, Wang X, Jiang S, Zhang Y (2025) Research on the characteristics of gut microbiota in overweight patients with early-onset type 2 diabetes mellitus. J Diabetes Investig. https:\/\/doi.org\/10.1111\/jdi.70074","journal-title":"J Diabetes Investig"},{"issue":"1","key":"10818_CR42","first-page":"i400","volume":"16","author":"NQM C","year":"2022","unstructured":"C NQM, C Q, K G HAB, Y O, N I NSPH, S M, N L, R H, A H, D G, T I (2022) P409 FMT induced increase in gut microbial diversity and clostridia is associated with clinical response in patients with ulcerative colitis \u2013 results from STOP colitis trial. J Crohn\u2019s Colitis 16(1):i400\u2013i400","journal-title":"J Crohn\u2019s Colitis"},{"key":"10818_CR43","doi-asserted-by":"publisher","first-page":"142156","DOI":"10.1016\/j.foodchem.2024.142156","volume":"467","author":"X Feng","year":"2024","unstructured":"Feng X, Chen Y, Luo L, Fang Z, Ma S, Li Z, Huang J, Pan Y, Lv H, Gong S, Zheng X, Fan F, Chen P, Zhu J, Chu Q (2024) Liubao insect tea polyphenols ameliorate DSS-induced experimental colitis by protecting intestinal barrier and regulating intestinal microbiota. Food Chem 467:142156","journal-title":"Food Chem"},{"issue":"1","key":"10818_CR44","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1038\/s41467-022-30240-8","volume":"13","author":"W Ruiqing","year":"2022","unstructured":"Ruiqing W, Xinyu Y, Jinting L, Fang Z, Chen Z, Yuhong C, Tao S, Chunyan J, Daoxin M (2022) Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate. Nat Commun 13(1):2522\u20132522","journal-title":"Nat Commun"},{"issue":"1","key":"10818_CR45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41522-024-00533-5","volume":"10","author":"TV Wehle","year":"2024","unstructured":"Wehle TV, Vital M (2024) Investigating the response of the butyrate production potential to major fibers in dietary intervention studies. NPJ Biofilms Microbiomes 10(1):63\u201363","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"11","key":"10818_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111116","volume":"27","author":"X Lv","year":"2024","unstructured":"Lv X, Zhan L, Ye T, Xie H, Chen Z, Lin Y, Cai X, Yang W, Liao X, Liu J, Sun J (2024) Gut commensal Agathobacter rectalis alleviates microglia-mediated neuroinflammation against pathogenesis of alzheimer disease. iScience 27(11):111116\u2013111116","journal-title":"iScience"},{"key":"10818_CR47","doi-asserted-by":"publisher","first-page":"1434150","DOI":"10.3389\/fnut.2024.1434150","volume":"11","author":"S Maruyama","year":"2024","unstructured":"Maruyama S, Matsuoka T, Hosomi K, Park J, Murakami H, Miyachi M, Kawashima H, Mizuguchi K, Kobayashi T, Ooka T, Yamagata Z, Kunisawa J (2024) High barley intake in non-obese individuals is associated with high Natto consumption and abundance of butyrate-producing bacteria in the gut: a cross-sectional study. Front Nutr 11:1434150\u20131434150","journal-title":"Front Nutr"},{"key":"10818_CR48","doi-asserted-by":"publisher","first-page":"1103836","DOI":"10.3389\/fmicb.2022.1103836","volume":"13","author":"S Vineet","year":"2023","unstructured":"Vineet S, GyuDae L, HyunWoo S, Hong K, Soo KE, Tatsuya U, Ho SJ (2023) Butyrate producers, the sentinel of gut: their intestinal significance with and beyond butyrate,and prospective use as microbial therapeutics. Front Microbiol 13:1103836\u20131103836","journal-title":"Front Microbiol"},{"issue":"5","key":"10818_CR49","doi-asserted-by":"publisher","first-page":"6375","DOI":"10.18632\/aging.202739","volume":"13","author":"G Claudia","year":"2021","unstructured":"Claudia G, Sylv\u00e8re D, Romain D, Kristina I, Fabien L, Lisa D, Fanny A, No\u00e9lie B, Nitharsshini N, Frank M, Laurence Z, Guido K (2021) Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites. Aging 13(5):6375\u20136405","journal-title":"Aging"},{"issue":"4","key":"10818_CR50","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.3390\/ijms24043900","volume":"24","author":"J Huafeng","year":"2023","unstructured":"Huafeng J, Yating L, Xiaoming W, Xinyang D, Xiaoting Z (2023) Akkermansia muciniphila as a next-generation probiotic in modulating human metabolic homeostasis and disease progression: a role mediated by Gut\u2013Liver\u2013Brain axes? Int J Mol Sci 24(4):3900\u20133900","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10818_CR51","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2406379","volume":"16","author":"ME Panzetta","year":"2024","unstructured":"Panzetta ME, Valdivia RH (2024) Akkermansia in the gastrointestinal tract as a modifier of human health. Gut Microbes 16(1):2406379","journal-title":"Gut Microbes"},{"key":"10818_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-023-10104-3","author":"MR Kathiriya","year":"2023","unstructured":"Kathiriya MR, Vekariya Y, Hati S (2023) Understanding the probiotic bacterial responses against various stresses in food matrix and gastrointestinal tract: a review. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-023-10104-3","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"2","key":"10818_CR53","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","volume":"47","author":"JM Ridlon","year":"2006","unstructured":"Ridlon JM, Kang DJ, Hylemon PB (2006) Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47(2):241\u2013259","journal-title":"J Lipid Res"},{"issue":"2","key":"10818_CR54","first-page":"37","volume":"18","author":"Y Wang","year":"2018","unstructured":"Wang Y, Hua X, Jia D, Wu Y, Dai W (2018) Lactobacillus rhamnosus B10 supernatant improving the barrier dysfunction of Caco-2 cell monolayer induced by alcohol. J Chin Inst Food Sci Technol 18(2):37\u201343","journal-title":"J Chin Inst Food Sci Technol"},{"issue":"11","key":"10818_CR55","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s13213-019-01500-8","volume":"69","author":"S Hati","year":"2019","unstructured":"Hati S, Patel M, Mishra BK, Das S (2019) Short-chain fatty acid and vitamin production potentials of Lactobacillus isolated from fermented foods of Khasi Tribes, Meghalaya, India. Ann Microbiol 69(11):1191\u20131199","journal-title":"Ann Microbiol"},{"key":"10818_CR56","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-024-01621-0","author":"YJ Kim","year":"2024","unstructured":"Kim YJ, Jung DH, Park CS (2024) Important roles of Ruminococcaceae in the human intestine for resistant starch utilization. Food Sci Biotechnol. https:\/\/doi.org\/10.1007\/s10068-024-01621-0","journal-title":"Food Sci Biotechnol"},{"key":"10818_CR57","doi-asserted-by":"crossref","unstructured":"Guo R, Shi AM, Deng L, Li L, Wang LC, Oteng AB, Wei MP, Zhao ZH, Hooiveld G, Zhang C (2022) Back cover. Short-Chain Fatty Acids Produced by Ruminococcaceae Mediate \u03b1-Linolenic Acid Promote Intestinal Stem Cells Proliferation. Mol Nutr Food Res 66(1):2270004","DOI":"10.1002\/mnfr.202270004"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10818-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10818-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10818-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:03:20Z","timestamp":1778753000000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10818-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10818"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10818-6","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"assertion":[{"value":"15 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}