{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:17:09Z","timestamp":1783397829843,"version":"3.54.6"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Nanjing Science and Technology Plan Project","award":["202110014"],"award-info":[{"award-number":["202110014"]}]},{"name":"Jiangsu Science and Technology Project","award":["BE2022704"],"award-info":[{"award-number":["BE2022704"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12602-025-10860-4","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:35:52Z","timestamp":1764156952000},"page":"5818-5837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential Benefits of Metformin Via Roseburia Intestinalis in High-fat Diet-fed Mice With Colorectal Adenomas"],"prefix":"10.1007","volume":"18","author":[{"given":"Jiankun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhining","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"5","key":"10860_CR1","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/his.12907","volume":"68","author":"RM Feakins","year":"2016","unstructured":"Feakins RM (2016) Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract. Histopathology 68(5):630\u2013640. https:\/\/doi.org\/10.1111\/his.12907","journal-title":"Histopathology"},{"key":"10860_CR2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2023.8549","author":"F Ma","year":"2023","unstructured":"Ma F, Lin Y, Ni Z, Chen T, Wang X (2023) Therapeutic effects of natural polyphenols on colorectal adenomas: focus on preclinical studies (Review). Oncol Rep. https:\/\/doi.org\/10.3892\/or.2023.8549","journal-title":"Oncol Rep"},{"key":"10860_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/dom.15756","volume":"26","author":"JR Petrie","year":"2024","unstructured":"Petrie JR (2024) Metformin beyond type 2 diabetes: emerging and potential new indications. Diabetes Obes Metab 26:31\u201341. https:\/\/doi.org\/10.1111\/dom.15756","journal-title":"Diabetes Obes Metab"},{"issue":"8","key":"10860_CR4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41574-023-00833-4","volume":"19","author":"M Foretz","year":"2023","unstructured":"Foretz M, Guigas B, Viollet B (2023) Metformin: update on mechanisms of action and repurposing potential. Nat Rev Endocrinol 19(8):460\u2013476. https:\/\/doi.org\/10.1038\/s41574-023-00833-4","journal-title":"Nat Rev Endocrinol"},{"key":"10860_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107367","volume":"208","author":"CR Sirtori","year":"2024","unstructured":"Sirtori CR, Castiglione S, Pavanello C (2024) Metformin: from diabetes to cancer to prolongation of life. Pharmacol Res 208:107367. https:\/\/doi.org\/10.1016\/j.phrs.2024.107367","journal-title":"Pharmacol Res"},{"key":"10860_CR6","doi-asserted-by":"publisher","first-page":"103037","DOI":"10.1016\/j.ebiom.2020.103037","volume":"61","author":"X Huang","year":"2020","unstructured":"Huang X, Hong X, Wang J, Sun T, Yu T, Yu Y, Fang J et al (2020) Metformin elicits antitumour effect by modulation of the gut microbiota and rescues Fusobacterium nucleatum-induced colorectal tumourigenesis. EBioMedicine 61:103037. https:\/\/doi.org\/10.1016\/j.ebiom.2020.103037","journal-title":"EBioMedicine"},{"key":"10860_CR7","doi-asserted-by":"publisher","first-page":"757718","DOI":"10.3389\/fcimb.2021.757718","volume":"11","author":"K Nie","year":"2021","unstructured":"Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T et al (2021) Roseburia intestinalis: a beneficial gut organism from the discoveries in genus and species. Front Cell Infect Microbiol 11:757718. https:\/\/doi.org\/10.3389\/fcimb.2021.757718","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10860_CR8","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1007\/s12602-025-10582-7","volume":"17","author":"MK Gupta","year":"2025","unstructured":"Gupta MK, Srivastava R (2025) Gut microbiome interventions: from dysbiosis to next-generation probiotics (NGPs) for disease management. Probiotics Antimicrob Proteins 17(4):2629\u20132652. https:\/\/doi.org\/10.1007\/s12602-025-10582-7","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"8","key":"10860_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12487","volume":"13","author":"HS Han","year":"2024","unstructured":"Han HS, Hwang S, Choi SY, Hitayezu E, Humphrey MA, Enkhbayar A, Song DG et al (2024) Roseburia intestinalis-derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses. J Extracell Vesicles 13(8):e12487. https:\/\/doi.org\/10.1002\/jev2.12487","journal-title":"J Extracell Vesicles"},{"issue":"11","key":"10860_CR10","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1136\/gutjnl-2023-330291","volume":"72","author":"X Kang","year":"2023","unstructured":"Kang X, Liu C, Ding Y, Ni Y, Ji F, Lau HCH, Jiang L et al (2023) Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8(+) T cells. Gut 72(11):2112\u20132122. https:\/\/doi.org\/10.1136\/gutjnl-2023-330291","journal-title":"Gut"},{"key":"10860_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104285","volume":"85","author":"Z Shen","year":"2022","unstructured":"Shen Z, Luo W, Tan B, Nie K, Deng M, Wu S, Xiao M et al (2022) Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn\u2019s disease. EBioMedicine 85:104285. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104285","journal-title":"EBioMedicine"},{"key":"10860_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010122","author":"S Bruscoli","year":"2021","unstructured":"Bruscoli S, Riccardi C, Ronchetti S (2021) GILZ as a regulator of cell fate and inflammation. Cells. https:\/\/doi.org\/10.3390\/cells11010122","journal-title":"Cells"},{"key":"10860_CR13","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.3389\/fimmu.2018.03111","volume":"9","author":"J Hoppstadter","year":"2018","unstructured":"Hoppstadter J, Diesel B, Linnenberger R, Hachenthal N, Flamini S, Minet M, Leidinger P et al (2018) Amplified host defense by Toll-Like Receptor-Mediated downregulation of the Glucocorticoid-Induced leucine zipper (GILZ) in macrophages. Front Immunol 9:3111. https:\/\/doi.org\/10.3389\/fimmu.2018.03111","journal-title":"Front Immunol"},{"issue":"18","key":"10860_CR14","doi-asserted-by":"publisher","first-page":"5177","DOI":"10.3748\/wjg.v20.i18.5177","volume":"20","author":"S Riondino","year":"2014","unstructured":"Riondino S, Roselli M, Palmirotta R, Della-Morte D, Ferroni P, Guadagni F (2014) Obesity and colorectal cancer: role of adipokines in tumor initiation and progression. World J Gastroenterol 20(18):5177\u20135190. https:\/\/doi.org\/10.3748\/wjg.v20.i18.5177","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10860_CR15","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3892\/mmr.2019.10327","volume":"20","author":"W Luo","year":"2019","unstructured":"Luo W, Shen Z, Deng M, Li X, Tan B, Xiao M, Wu S et al (2019) Roseburia intestinalis supernatant ameliorates colitis induced in mice by regulating the immune response. Mol Med Rep 20(2):1007\u20131016. https:\/\/doi.org\/10.3892\/mmr.2019.10327","journal-title":"Mol Med Rep"},{"issue":"1","key":"10860_CR16","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1186\/s12916-023-03034-y","volume":"21","author":"Z Luo","year":"2023","unstructured":"Luo Z, Wang B, Luo F, Guo Y, Jiang N, Wei J, Wang X et al (2023) Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening. BMC Med 21(1):336. https:\/\/doi.org\/10.1186\/s12916-023-03034-y","journal-title":"BMC Med"},{"issue":"1","key":"10860_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/ijc.2910340109","volume":"34","author":"C Paraskeva","year":"1984","unstructured":"Paraskeva C, Buckle BG, Sheer D, Wigley CB (1984) The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from Familial polyposis coli patients. Int J Cancer 34(1):49\u201356. https:\/\/doi.org\/10.1002\/ijc.2910340109","journal-title":"Int J Cancer"},{"key":"10860_CR18","doi-asserted-by":"publisher","unstructured":"Njau F, Haller H (2021) Calcium dobesilate modulates PKCdelta-NADPH Oxidase- MAPK-NF-kappaB signaling pathway to reduce CD14, TLR4, and MMP9 expression during Monocyte-to-Macrophage differentiation: potential therapeutic implications for atherosclerosis. Antioxid (Basel) 10(11). https:\/\/doi.org\/10.3390\/antiox10111798","DOI":"10.3390\/antiox10111798"},{"issue":"10","key":"10860_CR19","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/s41419-021-04235-0","volume":"12","author":"W Xiong","year":"2021","unstructured":"Xiong W, Sun KY, Zhu Y, Zhang X, Zhou YH, Zou X (2021) Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt. Cell Death Dis 12(10):934. https:\/\/doi.org\/10.1038\/s41419-021-04235-0","journal-title":"Cell Death Dis"},{"issue":"1","key":"10860_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02791-0","volume":"21","author":"S Wang","year":"2023","unstructured":"Wang S, Kuai Y, Lin S, Li L, Gu Q, Zhang X, Li X et al (2023) <article-title update=\u201cadded\u201d>NF-\u03baB activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer. BMC Med 21(1):115. https:\/\/doi.org\/10.1186\/s12916-023-02791-0","journal-title":"BMC Med"},{"issue":"9","key":"10860_CR21","doi-asserted-by":"publisher","first-page":"110620","DOI":"10.1016\/j.isci.2024.110620","volume":"27","author":"S Kabatnik","year":"2024","unstructured":"Kabatnik S, Post F, Drici L, Bartels AS, Strauss MT, Zheng X, Madsen GI et al (2024) Spatial characterization and stratification of colorectal adenomas by deep visual proteomics. iScience 27(9):110620. https:\/\/doi.org\/10.1016\/j.isci.2024.110620","journal-title":"iScience"},{"key":"10860_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13070819","author":"K Katsaounou","year":"2023","unstructured":"Katsaounou K, Yiannakou D, Nikolaou E, Brown C, Vogazianos P, Aristodimou A, Chi J et al (2023) Fecal microbiota and associated volatile organic compounds distinguishing no-adenoma from high-risk colon adenoma adults. Metabolites. https:\/\/doi.org\/10.3390\/metabo13070819","journal-title":"Metabolites"},{"issue":"1","key":"10860_CR23","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/jcmm.13342","volume":"22","author":"J Deng","year":"2018","unstructured":"Deng J, Zeng L, Lai X, Li J, Liu L, Lin Q, Chen Y (2018) Metformin protects against intestinal barrier dysfunction via AMPKalpha1-dependent inhibition of JNK signalling activation. J Cell Mol Med 22(1):546\u2013557. https:\/\/doi.org\/10.1111\/jcmm.13342","journal-title":"J Cell Mol Med"},{"key":"10860_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101498","volume":"61","author":"LA Broadfield","year":"2022","unstructured":"Broadfield LA, Saigal A, Szamosi JC, Hammill JA, Bezverbnaya K, Wang D, Gautam J et al (2022) Metformin-induced reductions in tumor growth involves modulation of the gut microbiome. Mol Metab 61:101498. https:\/\/doi.org\/10.1016\/j.molmet.2022.101498","journal-title":"Mol Metab"},{"key":"10860_CR25","doi-asserted-by":"publisher","first-page":"1004617","DOI":"10.3389\/fphar.2022.1004617","volume":"13","author":"D Wang","year":"2022","unstructured":"Wang D, Liu J, Zhong L, Ding L, Zhang Q, Yu M, Li M et al (2022) Potential benefits of Metformin and Pioglitazone combination therapy via gut microbiota and metabolites in high-fat diet-fed mice. Front Pharmacol 13:1004617. https:\/\/doi.org\/10.3389\/fphar.2022.1004617","journal-title":"Front Pharmacol"},{"key":"10860_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126837","author":"E Ermolenko","year":"2022","unstructured":"Ermolenko E, Simanenkova A, Voropaeva L, Lavrenova N, Kotyleva M, Minasian S, Chernikova A et al (2022) Metformin influence on the intestinal microbiota and organism of rats with metabolic syndrome. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23126837","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10860_CR27","doi-asserted-by":"publisher","first-page":"2263934","DOI":"10.1080\/19490976.2023.2263934","volume":"15","author":"Y Cao","year":"2023","unstructured":"Cao Y, Wang J, Hou W, Ding Y, Zhu Y, Zheng J, Huang Q et al (2023) Colorectal cancer-associated T cell receptor repertoire abnormalities are linked to gut microbiome shifts and somatic cell mutations. Gut Microbes 15(2):2263934. https:\/\/doi.org\/10.1080\/19490976.2023.2263934","journal-title":"Gut Microbes"},{"issue":"10","key":"10860_CR28","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1016\/j.apsb.2023.08.002","volume":"13","author":"LL Pan","year":"2023","unstructured":"Pan LL, Ren ZN, Yang J, Li BB, Huang YW, Song DX, Li X et al (2023) Gut microbiota controls the development of chronic pancreatitis: a critical role of short-chain fatty acids-producing Gram-positive bacteria. Acta Pharm Sin B 13(10):4202\u20134216. https:\/\/doi.org\/10.1016\/j.apsb.2023.08.002","journal-title":"Acta Pharm Sin B"},{"key":"10860_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2024.101941","volume":"45","author":"B Huang","year":"2024","unstructured":"Huang B, Yu Z, Cui D, Du F (2024) MAPKAP1 orchestrates macrophage polarization and lipid metabolism in fatty liver-enhanced colorectal cancer. Transl Oncol 45:101941. https:\/\/doi.org\/10.1016\/j.tranon.2024.101941","journal-title":"Transl Oncol"},{"issue":"1","key":"10860_CR30","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/s42003-022-03305-z","volume":"5","author":"TV Rohm","year":"2022","unstructured":"Rohm TV, Keller L, Bosch AJT, AlAsfoor S, Baumann Z, Thomas A, Wiedemann SJ et al (2022) Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity. Commun Biol 5(1):370. https:\/\/doi.org\/10.1038\/s42003-022-03305-z","journal-title":"Commun Biol"},{"issue":"1","key":"10860_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1819155","volume":"12","author":"L Wang","year":"2020","unstructured":"Wang L, Gong Z, Zhang X, Zhu F, Liu Y, Jin C, Du X et al (2020) Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation. Gut Microbes 12(1):1\u201320. https:\/\/doi.org\/10.1080\/19490976.2020.1819155","journal-title":"Gut Microbes"},{"key":"10860_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030532","author":"JAM Souza","year":"2022","unstructured":"Souza JAM, Carvalho AFS, Grossi LC, Zaidan I, de Oliveira LC, Vago JP, Cardoso C et al (2022) Glucocorticoid-induced leucine zipper alleviates lung inflammation and enhances bacterial clearance during pneumococcal pneumonia. Cells. https:\/\/doi.org\/10.3390\/cells11030532","journal-title":"Cells"},{"issue":"4","key":"10860_CR33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/eji.202048582","volume":"50","author":"J Vandewalle","year":"2020","unstructured":"Vandewalle J, Libert C (2020) GILZ in sepsis: poor is the pupil who does not surpass his master. Eur J Immunol 50(4):490\u2013493. https:\/\/doi.org\/10.1002\/eji.202048582","journal-title":"Eur J Immunol"},{"key":"10860_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104842","volume":"158","author":"JP Vago","year":"2020","unstructured":"Vago JP, Galvao I, Negreiros-Lima GL, Teixeira LCR, Lima KM, Sugimoto MA, Moreira IZ et al (2020) Glucocorticoid-induced leucine zipper modulates macrophage polarization and apoptotic cell clearance. Pharmacol Res 158:104842. https:\/\/doi.org\/10.1016\/j.phrs.2020.104842","journal-title":"Pharmacol Res"},{"key":"10860_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/cells12182294","author":"M Paglialunga","year":"2023","unstructured":"Paglialunga M, Flamini S, Contini R, Febo M, Ricci E, Ronchetti S, Bereshchenko O et al (2023) Anti-inflammatory effects of synthetic peptides based on glucocorticoid-induced leucine zipper (GILZ) protein for the treatment of inflammatory bowel diseases (IBDs). Cells. https:\/\/doi.org\/10.3390\/cells12182294","journal-title":"Cells"},{"key":"10860_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113683","volume":"144","author":"X Lai","year":"2025","unstructured":"Lai X, Liu B, Wan Y, Zhou P, Li W, Hu W, Gong W (2025) Metformin alleviates colitis-associated colorectal cancer via inhibition of the TLR4\/MyD88\/NF\u03baB\/MAPK pathway and macrophage M2 polarization. Int Immunopharmacol 144:113683. https:\/\/doi.org\/10.1016\/j.intimp.2024.113683","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"10860_CR37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100778RRRR","volume":"35","author":"M Gentili","year":"2021","unstructured":"Gentili M, Hidalgo-Garcia L, Vezza T, Ricci E, Migliorati G, Rodriguez-Nogales A, Riccardi C et al (2021) A recombinant glucocorticoid-induced leucine zipper protein ameliorates symptoms of dextran sulfate sodium-induced colitis by improving intestinal permeability. FASEB J 35(11):e21950. https:\/\/doi.org\/10.1096\/fj.202100778RRRR","journal-title":"FASEB J"},{"issue":"3","key":"10860_CR38","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/path.4527","volume":"236","author":"MD Burkitt","year":"2015","unstructured":"Burkitt MD, Hanedi AF, Duckworth CA, Williams JM, Tang JM, O\u2019Reilly LA, Putoczki TL et al (2015) NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL\/6 mice. J Pathol 236(3):326\u2013336. https:\/\/doi.org\/10.1002\/path.4527","journal-title":"J Pathol"},{"key":"10860_CR39","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.3389\/fimmu.2019.01823","volume":"10","author":"L Cannarile","year":"2019","unstructured":"Cannarile L, Delfino DV, Adorisio S, Riccardi C, Ayroldi E (2019) Implicating the role of GILZ in glucocorticoid modulation of T-Cell activation. Front Immunol 10:1823. https:\/\/doi.org\/10.3389\/fimmu.2019.01823","journal-title":"Front Immunol"},{"key":"10860_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113153","author":"M Docq","year":"2021","unstructured":"Docq M, Vetillard M, Gallego C, Jaracz-Ros A, Mercier-Nome F, Bachelerie F, Schlecht-Louf G (2021) Multi-tissue characterization of GILZ expression in dendritic cell subsets at steady state and in inflammatory contexts. Cells. https:\/\/doi.org\/10.3390\/cells10113153","journal-title":"Cells"},{"issue":"7","key":"10860_CR41","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1194\/jlr.M067728","volume":"57","author":"MJ Lee","year":"2016","unstructured":"Lee MJ, Yang RZ, Karastergiou K, Smith SR, Chang JR, Gong DW, Fried SK (2016) Low expression of the GILZ may contribute to adipose inflammation and altered adipokine production in human obesity. J Lipid Res 57(7):1256\u20131263. https:\/\/doi.org\/10.1194\/jlr.M067728","journal-title":"J Lipid Res"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10860-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10860-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10860-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:39:34Z","timestamp":1783395574000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10860-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10860"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10860-4","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"20 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted following the Guide for the Care and Use of Laboratory Animals (Eighth Edition) issued by the NIH. The Institutional Animal Care and Use Committee of Nanjing Medical University approved animal studies (approval number: IACUC-2207054).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}