{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:17:25Z","timestamp":1783397845131,"version":"3.54.6"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12602-025-10884-w","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T08:26:46Z","timestamp":1766824006000},"page":"6276-6292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Protective Role of Different Probiotic Strains against Bacterial and Endotoxin-Induced Sepsis in a Mouse Model"],"prefix":"10.1007","volume":"18","author":[{"given":"Sabeeka","family":"Sajjal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnat Ahmad","family":"Bilal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambreen","family":"Zahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Musa","family":"Mubashar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Khatoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-9054","authenticated-orcid":false,"given":"Muhammad Imran","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"10884_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s40168-020-00866-1","volume":"8","author":"Y Liu","year":"2020","unstructured":"Liu Y, Liu Y, Du Z, Zhang L, Chen J, Shen Z, Liu Q, Qin J, Lv H, Wang H (2020) Skin microbiota analysis-inspired development of novel anti-infectives. Microbiome 8:85","journal-title":"Microbiome"},{"key":"10884_CR2","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/ijms21020379","volume":"21","author":"L Mazgaeen","year":"2020","unstructured":"Mazgaeen L, Gurung P (2020) Recent advances in lipopolysaccharide recognition systems. Int J Mol Sci 21:379","journal-title":"Int J Mol Sci"},{"key":"10884_CR3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1080\/07388551.2019.1709797","volume":"40","author":"A Basauri","year":"2020","unstructured":"Basauri A, Gonz\u00e1lez-Fern\u00e1ndez C, Fallanza M, Bringas E, Fernandez-Lopez R, Giner L, Moncali\u00e1n G, de la Cruz F, Ortiz I (2020) Biochemical interactions between LPS and LPS-binding molecules. Crit Rev Biotechnol 40:292\u2013305","journal-title":"Crit Rev Biotechnol"},{"key":"10884_CR4","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/1348-0421.12837","volume":"64","author":"P Sarichai","year":"2020","unstructured":"Sarichai P, Buddhasiri S, Walters GE, Khantawa B, Kaewsakhorn T, Chantarasakha K, Tepaamorndech S, Thiennimitr P (2020) Pathogenicity of clinical Salmonella enterica serovar Typhimurium isolates from Thailand in a mouse colitis model. Microbiol Immunol 64:679\u2013693","journal-title":"Microbiol Immunol"},{"key":"10884_CR5","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1007\/s12602-024-10275-7","volume":"16","author":"F Al-Akayleh","year":"2024","unstructured":"Al-Akayleh F, Agha ASA, Al-Remawi M, Al-Adham IS, Daadoue S, Alsisan A, Khattab D, Malath D, Salameh H, Al-Betar M (2024) What we know about the actual role of traditional probiotics in health and disease. Probiotics Antimicrob Proteins 16:1836\u20131856","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10884_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41579-022-00780-3","volume":"21","author":"MM Severn","year":"2023","unstructured":"Severn MM, Horswill AR (2023) Staphylococcus epidermidis and its dual lifestyle in skin health and infection. Nat Rev Microbiol 21:97\u2013111","journal-title":"Nat Rev Microbiol"},{"key":"10884_CR7","doi-asserted-by":"publisher","first-page":"e00930","DOI":"10.1128\/mbio.00930-22","volume":"13","author":"MM Severn","year":"2022","unstructured":"Severn MM, Williams MR, Shahbandi A, Bunch ZL, Lyon LM, Nguyen A, Zaramela LS, Todd DA, Zengler K, Cech NB (2022) The ubiquitous human skin commensal Staphylococcus hominis protects against opportunistic pathogens. mBio 13:e00930\u2013e00922","journal-title":"mBio"},{"key":"10884_CR8","first-page":"1","volume":"27","author":"M Borah","year":"2024","unstructured":"Borah M, Mandal M, Konwar BK (2024) Characterization of probiotic strains of Bacillus sp. from fermented palm wine (Nypa fructicans sp.) and exploration of cellulolytic potential for use as an addition in animal feed. Int Microbiol 27:1\u201313","journal-title":"Int Microbiol"},{"key":"10884_CR9","volume":"13","author":"M Matera","year":"2025","unstructured":"Matera M, Palazzi CM, Bertuccioli A, Di Pierro F, Zerbinati N, Cazzaniga M, Gregoretti A, Cavecchia I (2025) The role of targeted microbiota therapy in the prevention and management of puerperal mastitis. Dis 13:176","journal-title":"Dis"},{"key":"10884_CR10","volume":"14","author":"S Poorni","year":"2022","unstructured":"Poorni S, Nivedhitha M, Srinivasan M, Balasubramaniam A (2022) Effect of probiotic Streptococcus salivarius K12 and M18 lozenges on the cariogram parameters of patients with high caries risk: a randomised control trial. Cureus 14:e22919","journal-title":"Cureus"},{"key":"10884_CR11","doi-asserted-by":"publisher","first-page":"797445","DOI":"10.3389\/fmicb.2021.797445","volume":"12","author":"K Srikham","year":"2021","unstructured":"Srikham K, Daengprok W, Niamsup P, Thirabunyanon M (2021) Characterization of Streptococcus salivarius as new probiotics derived from human breast milk and their potential on proliferative inhibition of liver and breast cancer cells and antioxidant activity. Front Microbiol 12:797445","journal-title":"Front Microbiol"},{"key":"10884_CR12","doi-asserted-by":"crossref","unstructured":"Saeed A, Ali H, Yasmin A, Baig M, Ullah A, Kazmi A, Ahmed MA, Albadrani GM, El-Demerdash FM, Bibi M (2023) Unveiling the antibiotic susceptibility and antimicrobial potential of bacteria from human breast milk of Pakistani women: an exploratory study. Biomed Res Int 2023:6399699","DOI":"10.1155\/2023\/6399699"},{"key":"10884_CR13","doi-asserted-by":"publisher","first-page":"156232","DOI":"10.1016\/j.cyto.2023.156232","volume":"168","author":"A Saeed","year":"2023","unstructured":"Saeed A, Yasmin A, Baig M, Ahmed MA, Farooqi Z, -u-R (2023b) Streptococcus lactarius MB622 and Streptococcus salivarius MB620 isolated from human milk reduce chemokine IL-8 production in response to TNF-\u03b1 in Caco-2 cell line, an exploratory study. Cytokine 168:156232","journal-title":"Cytokine"},{"key":"10884_CR14","doi-asserted-by":"publisher","first-page":"939213","DOI":"10.3389\/fimmu.2022.939213","volume":"13","author":"F Alby-Laurent","year":"2022","unstructured":"Alby-Laurent F, Bela\u00efdouni N, Blanchet B, Rousseau C, Llitjos JF, Sanquer S, Mira JP, P\u00e8ne F, Toubiana J, Chiche JD (2022) Low-dose mycophenolate mofetil improves survival in a murine model of Staphylococcus aureus sepsis by increasing bacterial clearance and phagocyte function. Front Immunol 13:939213","journal-title":"Front Immunol"},{"key":"10884_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.997","volume":"4","author":"SK Kannan","year":"2024","unstructured":"Kannan SK, Kim CY, Heidarian M, Berton RR, Jensen IJ, Griffith TS, Badovinac VP (2024) Mouse models of sepsis. Curr Protoc 4:e997","journal-title":"Curr Protoc"},{"key":"10884_CR16","doi-asserted-by":"publisher","first-page":"7423","DOI":"10.1039\/D2FO00911K","volume":"13","author":"H Kaur","year":"2022","unstructured":"Kaur H, Ali SA (2022) Probiotics and gut microbiota: mechanistic insights into gut immune homeostasis through TLR pathway regulation. Food Funct 13:7423\u20137447","journal-title":"Food Funct"},{"key":"10884_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115921","volume":"22","author":"G Kim","year":"2021","unstructured":"Kim G, Choi KH, Kim H, Chung DK (2021) Alleviation of LPS-induced inflammation and septic shock by Lactiplantibacillus plantarum K8 lysates. Int J Mol Sci 22:5921","journal-title":"Int J Mol Sci"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10884-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-025-10884-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-025-10884-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:40:01Z","timestamp":1783395601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-025-10884-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,27]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10884"],"URL":"https:\/\/doi.org\/10.1007\/s12602-025-10884-w","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,27]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures involving lab animals were conducted in compliance with the animal welfare and ethical standards of the Institutional Biosafety and Bioethics Committee of the University of Agriculture, Faisalabad (UAF), Pakistan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}