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The purified bacteriocin preparation exhibited strong antibacterial activity against indicator strain\n                    <jats:italic>Latilactobacillus sakei<\/jats:italic>\n                    NCDO 2714. Cytotoxicity testing in RAW 264.7 macrophages revealed minimal effects at concentrations up to 50\u00a0\u00b5g\/ml, with only a modest reduction in cell viability observed at 100\u00a0\u00b5g\/ml. Subsequent evaluation of immunomodulatory properties demonstrated a clear dose-dependent anti-inflammatory effect in LPS-stimulated macrophages. Treatment with gassericins K7 reduced nitric oxide (NO) production, downregulated inducible nitric oxide synthase (iNOS) expression, and suppressed secretion of the pro-inflammatory cytokines TNF-\u03b1 and IL-6. Importantly, exposure of macrophages to gassericins alone did not elicit any inflammatory response. These findings provide the first evidence of anti-inflammatory activity of purified gassericins K7 in eukaryotic immune cells and highlight their potential as postbiotic components or biotherapeutic candidates for inflammatory disorders. The preparative method used in this study enables the production of gassericins K7 in quantities sufficient for advanced in vitro\u00a0and in vivo investigations, facilitating future development of bacteriocin-based therapeutics.\n                  <\/jats:p>","DOI":"10.1007\/s12602-025-10910-x","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:25:51Z","timestamp":1770434751000},"page":"7062-7073","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gassericins from Lactobacillus Paragasseri K7: Preparative Isolation and Discovery of Dose-Dependent Anti-Inflammatory Effects"],"prefix":"10.1007","volume":"18","author":[{"given":"Humna","family":"Liaqat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Pavelj\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jernej","family":"Ober\u010dkal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Ambro\u017eov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00fdna","family":"Turkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1\u0161","family":"Kubala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrijana","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kri\u017eaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana Bogovi\u010d","family":"Matija\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"issue":"20","key":"10910_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015256","volume":"24","author":"J Tan","year":"2023","unstructured":"Tan J, Taitz J, Nanan R, Grau G, Macia L (2023) Dysbiotic gut microbiota-derived metabolites and their role in non-communicable diseases. 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