{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:15:19Z","timestamp":1788822919021,"version":"build-2803163510"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100008552","name":"Haryana State Council for Science and Technology","doi-asserted-by":"publisher","award":["HSCSIT\/R&D\/2025\/617"],"award-info":[{"award-number":["HSCSIT\/R&D\/2025\/617"]}],"id":[{"id":"10.13039\/501100008552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s12602-026-10941-y","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:14:05Z","timestamp":1771236845000},"page":"7237-7253","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifactorial Neuroprotective Potential of \u03b3-Aminobutyric acid-Producing Potential Probiotics Against Stress Induced Neuronal Cell Lines"],"prefix":"10.1007","volume":"18","author":[{"given":"Souparno","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayani","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugato","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"10941_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3746\/jfn.2003.8.1.075","volume":"8","author":"S-H Oh","year":"2003","unstructured":"Oh S-H, Moon Y-J (2003) Oh, \u03b3 -aminobutyric acid (GABA) content of selected uncooked foods. Prev Nutr Food Sci 8:75\u201378. https:\/\/doi.org\/10.3746\/jfn.2003.8.1.075","journal-title":"Prev Nutr Food Sci"},{"key":"10941_CR2","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1590\/S1517-83822012000400001","volume":"43","author":"R Dhakal","year":"2012","unstructured":"Dhakal R, Bajpai VK, Baek K-H (2012) Production of GABA (\u03b3 - aminobutyric acid) by microorganisms: a review. Braz J Microbiol 43:1230\u20131241","journal-title":"Braz J Microbiol"},{"key":"10941_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05526","author":"NRM Sahab","year":"2020","unstructured":"Sahab NRM, Subroto E, Balia RL, Utama GL (2020) \u03b3-aminobutyric acid found in fermented foods and beverages: current trends. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2020.e05526","journal-title":"Heliyon"},{"key":"10941_CR4","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.3390\/microorganisms8121923","volume":"8","author":"IBA Yogeswara","year":"2020","unstructured":"Yogeswara IBA, Maneerat S, Haltrich D (2020) Glutamate decarboxylase from lactic acid bacteria-a key enzyme in GABA synthesis. Microorganisms 8:1923","journal-title":"Microorganisms"},{"key":"10941_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jpsychires.2025.05.053","volume":"188","author":"R Moshfeghinia","year":"2025","unstructured":"Moshfeghinia R, Nemati H, Ebrahimi A, Shekouh D, Karami S, Eraghi MM, Mohagheghzadeh H, Hunter J, Pasalar M (2025) The impact of probiotics, prebiotics, and synbiotics on depression and anxiety symptoms of patients with depression: a systematic review and meta-analysis. J Psychiatr Res 188:104\u2013116. https:\/\/doi.org\/10.1016\/j.jpsychires.2025.05.053","journal-title":"J Psychiatr Res"},{"key":"10941_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04846-0","author":"YN Ramadan","year":"2025","unstructured":"Ramadan YN, Alqifari SF, Alshehri K, Alhowiti A, Mirghani H, Alrasheed T, Aljohani F, Alghamdi A, Hetta HF (2025) Microbiome gut-brain-axis: impact on brain development and mental health. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-025-04846-0","journal-title":"Mol Neurobiol"},{"key":"10941_CR7","doi-asserted-by":"publisher","first-page":"e70029","DOI":"10.1111\/jnc.70029","volume":"169","author":"JV Andersen","year":"2025","unstructured":"Andersen JV (2025) The glutamate\/GABA-glutamine cycle: insights, updates, and advances. J Neurochem 169:e70029. https:\/\/doi.org\/10.1111\/jnc.70029","journal-title":"J Neurochem"},{"key":"10941_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2174\/1570159X22666240815120244","volume":"23","author":"M Mamelak","year":"2025","unstructured":"Mamelak M (2025) Depression and the glutamate\/GABA-glutamine cycle. Curr Neuropharmacol 23:75\u201384. https:\/\/doi.org\/10.2174\/1570159X22666240815120244","journal-title":"Curr Neuropharmacol"},{"key":"10941_CR9","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1007\/s11756-023-01512-5","volume":"78","author":"V Jhamb","year":"2023","unstructured":"Jhamb V, Swaminathan P (2023) Role and importance of lactic acid bacteria in different Indian fermented foods. Biologia 78:3609\u20133623. https:\/\/doi.org\/10.1007\/s11756-023-01512-5","journal-title":"Biologia"},{"key":"10941_CR10","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/02601060221085138","volume":"28","author":"U Sarma","year":"2022","unstructured":"Sarma U, Gupta S (2022) An overview on ethnic fermented food and beverages of India: interplay of microbes, immunity and nutrition. Nutr Health 28:331\u2013339. https:\/\/doi.org\/10.1177\/02601060221085138","journal-title":"Nutr Health"},{"key":"10941_CR11","doi-asserted-by":"publisher","first-page":"e17634","DOI":"10.1111\/1750-3841.17634","volume":"90","author":"A Singh","year":"2025","unstructured":"Singh A, Negi PS (2025) Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation. J Food Sci 90:e17634. https:\/\/doi.org\/10.1111\/1750-3841.17634","journal-title":"J Food Sci"},{"key":"10941_CR12","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.lwt.2014.11.013","volume":"61","author":"D Das","year":"2015","unstructured":"Das D, Goyal A (2015) Antioxidant activity and \u03b3-aminobutyric acid (GABA) producing ability of probiotic Lactobacillus plantarum DM5 isolated from Marcha of Sikkim, lebenson. Wiss Technol 61:263\u2013268","journal-title":"Wiss Technol"},{"key":"10941_CR13","doi-asserted-by":"publisher","first-page":"101650","DOI":"10.1016\/j.eti.2021.101650","volume":"23","author":"P Sharma","year":"2021","unstructured":"Sharma P, Sharma A, Singh J, Singh N, Singh S, Tomar GS, Nain PKS, Khare SK, Nain L (2021) Co-production of gamma amino butyric acid (GABA) and lactic acid using Lactobacillus plantarum LP-9 from agro-residues. Environ Technol Innov 23:101650","journal-title":"Environ Technol Innov"},{"key":"10941_CR14","doi-asserted-by":"publisher","first-page":"114511","DOI":"10.1016\/j.lwt.2023.114511","volume":"176","author":"PB Devi","year":"2023","unstructured":"Devi PB, Rajapuram DR, Jayamanohar J, Verma M, Kavitake D, Meenachi Avany BA, Rani PU, Ravi R, Shetty PH (2023) Gamma-aminobutyric acid (GABA) production by potential probiotic strains of indigenous fermented foods origin and RSM based production optimization. Lebenson. Wiss. Technol. 176:114511","journal-title":"Lebenson. Wiss. Technol."},{"key":"10941_CR15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s12602-021-09759-7","volume":"13","author":"S Bs","year":"2021","unstructured":"Bs S, Thankappan B, Mahendran R, Muthusamy G, Femil Selta DR, Angayarkanni J (2021) Evaluation of GABA production and probiotic activities of Enterococcus faecium BS5. Probiotics Antimicrob Proteins 13:993\u20131004","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10941_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00284-023-03580-x","volume":"81","author":"N Sori","year":"2024","unstructured":"Sori N, Khan M (2024) Gamma amino butyric acid (GABA) and ferulic acid esterase (FAE) producing psychobiotic bacteria isolated from cereal-based fermented food. Curr Microbiol 81:59","journal-title":"Curr Microbiol"},{"key":"10941_CR17","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12934-023-02264-2","volume":"22","author":"S Kaur","year":"2023","unstructured":"Kaur S, Sharma P, Mayer MJ, Neuert S, Narbad A, Kaur S (2023) Beneficial effects of GABA-producing potential probiotic Limosilactobacillus fermentum L18 of human origin on intestinal permeability and human gut microbiota. Microb Cell Fact 22:256","journal-title":"Microb Cell Fact"},{"key":"10941_CR18","doi-asserted-by":"publisher","first-page":"4038","DOI":"10.3390\/cells11244038","volume":"11","author":"M Kalyan","year":"2022","unstructured":"Kalyan M, Tousif AH, Sonali S, Vichitra C, Sunanda T, Praveenraj SS, Ray B, Gorantla VR, Rungratanawanich W, Mahalakshmi AM, Qoronfleh MW, Monaghan TM, Song B-J, Essa MM, Chidambaram SB (2022) Role of endogenous lipopolysaccharides in neurological disorders. Cells 11:4038. https:\/\/doi.org\/10.3390\/cells11244038","journal-title":"Cells"},{"key":"10941_CR19","doi-asserted-by":"publisher","first-page":"5790","DOI":"10.1038\/s41598-019-42286-8","volume":"9","author":"J Zhao","year":"2019","unstructured":"Zhao J, Bi W, Xiao S, Lan X, Cheng X, Zhang J, Lu D, Wei W, Wang Y, Li H, Fu Y, Zhu L (2019) Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Sci Rep 9:5790. https:\/\/doi.org\/10.1038\/s41598-019-42286-8","journal-title":"Sci Rep"},{"key":"10941_CR20","doi-asserted-by":"publisher","first-page":"104710","DOI":"10.1016\/j.jff.2021.104710","volume":"86","author":"S Kittibunchakul","year":"2021","unstructured":"Kittibunchakul S, Yuthaworawit N, Whanmek K, Suttisansanee U, Santivarangkna C (2021) Health beneficial properties of a novel plant-based probiotic drink produced by fermentation of brown rice milk with GABA-producing Lactobacillus pentosus isolated from Thai pickled weed. J Funct Foods 86:104710","journal-title":"J Funct Foods"},{"key":"10941_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s13594-013-0127-4","volume":"93","author":"N Lacroix","year":"2013","unstructured":"Lacroix N, St-Gelais D, Champagne CP, Vuillemard JC (2013) Gamma-aminobutyric acid-producing abilities of lactococcal strains isolated from old-style cheese starters. Dairy Sci Technol 93:315\u2013327","journal-title":"Dairy Sci Technol"},{"key":"10941_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27658-5","author":"MR Edalatian Dovom","year":"2023","unstructured":"Edalatian Dovom MR, Habibi Najafi MB, Rahnama Vosough P, Norouzi N, Ebadi Nezhad SJ, Mayo B (2023) Screening of lactic acid bacteria strains isolated from Iranian traditional dairy products for GABA production and optimization by response surface methodology. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-023-27658-5","journal-title":"Sci Rep"},{"key":"10941_CR23","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.foodchem.2010.02.071","volume":"122","author":"B-J Lee","year":"2010","unstructured":"Lee B-J, Kim J-S, Kang YM, Lim J-H, Kim Y-M, Lee M-S, Jeong M-H, Ahn C-B, Je J-Y (2010) Antioxidant activity and \u03b3-aminobutyric acid (GABA) content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods. Food Chem 122:271\u2013276","journal-title":"Food Chem"},{"key":"10941_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88436-9","author":"FS Hussin","year":"2021","unstructured":"Hussin FS, Chay SY, Hussin ASM, Wan Ibadullah WZ, Muhialdin BJ, Abd Ghani MS, Saari N (2021) GABA enhancement by simple carbohydrates in yoghurt fermented using novel, self-cloned Lactobacillus plantarum Taj-Apis362 and metabolomics profiling. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-88436-9","journal-title":"Sci Rep"},{"key":"10941_CR25","doi-asserted-by":"publisher","first-page":"108992","DOI":"10.1016\/j.lwt.2019.108992","volume":"121","author":"BJ Muhialdin","year":"2020","unstructured":"Muhialdin BJ, Kadum H, Zarei M, Hussin AM (2020) Effects of metabolite changes during lacto-fermentation on the biological activity and consumer acceptability for dragon fruit juice. LWT 121:108992. https:\/\/doi.org\/10.1016\/j.lwt.2019.108992","journal-title":"LWT"},{"key":"10941_CR26","doi-asserted-by":"publisher","first-page":"126057","DOI":"10.1016\/j.foodchem.2019.126057","volume":"311","author":"K Ragul","year":"2020","unstructured":"Ragul K, Kandasamy S, Devi PB, Shetty PH (2020) Evaluation of functional properties of potential probiotic isolates from fermented brine pickle. Food Chem 311:126057","journal-title":"Food Chem"},{"key":"10941_CR27","doi-asserted-by":"publisher","first-page":"105230","DOI":"10.1016\/j.jff.2022.105230","volume":"97","author":"L Diez-Guti\u00e9rrez","year":"2022","unstructured":"Diez-Guti\u00e9rrez L, San Vicente L, S\u00e1enz J, Barron LJR, Ch\u00e1varri M (2022) Characterisation of the probiotic potential of Lactiplantibacillus plantarum K16 and its ability to produce the postbiotic metabolite \u03b3-aminobutyric acid. J Funct Foods 97:105230","journal-title":"J Funct Foods"},{"key":"10941_CR28","doi-asserted-by":"publisher","first-page":"e0192978","DOI":"10.1371\/journal.pone.0192978","volume":"13","author":"R Dowarah","year":"2018","unstructured":"Dowarah R, Verma AK, Agarwal N, Singh P, Singh BR (2018) Selection and characterization of probiotic lactic acid bacteria and its impact on growth, nutrient digestibility, health and antioxidant status in weaned piglets. PLoS One 13:e0192978","journal-title":"PLoS One"},{"key":"10941_CR29","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.resmic.2015.03.002","volume":"166","author":"M Anandharaj","year":"2015","unstructured":"Anandharaj M, Sivasankari B, Santhanakaruppu R, Manimaran M, Rani RP, Sivakumar S (2015) Determining the probiotic potential of cholesterol-reducing Lactobacillus and Weissella strains isolated from Gherkins (fermented cucumber) and South Indian fermented Koozh. Res Microbiol 166:428\u2013439","journal-title":"Res Microbiol"},{"key":"10941_CR30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jbiosc.2014.01.015","volume":"118","author":"M Anandharaj","year":"2014","unstructured":"Anandharaj M, Sivasankari B (2014) Isolation of potential probiotic Lactobacillus oris HMI68 from mother\u2019s milk with cholesterol-reducing property. J Biosci Bioeng 118:153\u2013159","journal-title":"J Biosci Bioeng"},{"key":"10941_CR31","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1017\/S0022029918000432","volume":"85","author":"N Rokana","year":"2018","unstructured":"Rokana N, Singh BP, Thakur N, Sharma C, Gulhane RD, Panwar H (2018) Screening of cell surface properties of potential probiotic lactobacilli isolated from human milk. J Dairy Res 85:347\u2013354","journal-title":"J Dairy Res"},{"key":"10941_CR32","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s00217-007-0632-x","volume":"226","author":"MC Collado","year":"2008","unstructured":"Collado MC, Meriluoto J, Salminen S (2008) Adhesion and aggregation properties of probiotic and pathogen strains. Eur Food Res Technol 226:1065\u20131073","journal-title":"Eur Food Res Technol"},{"key":"10941_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3390\/fermentation8010029","volume":"8","author":"S Kim","year":"2022","unstructured":"Kim S, Lee JY, Jeong Y, Kang C-H (2022) Antioxidant activity and probiotic properties of lactic acid bacteria. Fermentation 8:29","journal-title":"Fermentation"},{"key":"10941_CR34","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1080\/10408398.2021.1957765","volume":"63","author":"S Lee","year":"2023","unstructured":"Lee S, Jo K, Jeong HG, Choi Y-S, Yong HI, Jung S (2023) Understanding protein digestion in infants and the elderly: current in vitro digestion models. Crit Rev Food Sci Nutr 63:975\u2013992","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10941_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/microorganisms8020189","volume":"8","author":"A Cozzolino","year":"2020","unstructured":"Cozzolino A, Vergalito F, Tremonte P, Iorizzo M, Lombardi SJ, Sorrentino E, Luongo D, Coppola R, Di Marco R, Succi M (2020) Preliminary evaluation of the safety and probiotic potential of Akkermansia muciniphila DSM 22959 in comparison with Lactobacillus rhamnosus GG. Microorganisms 8:189","journal-title":"Microorganisms"},{"key":"10941_CR36","doi-asserted-by":"crossref","unstructured":"Shipley MM, Mangold CA, Szpara ML (2016) Differentiation of the SH-SY5Y human neuroblastoma cell line. J Vis Exp 53193","DOI":"10.3791\/53193-v"},{"key":"10941_CR37","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.brainresbull.2003.09.011","volume":"62","author":"Z Datki","year":"2003","unstructured":"Datki Z, Juh\u00e1sz A, G\u00e1lfi M, So\u00f3s K, Papp R, Z\u00e1dori D, Penke B (2003) Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells. Brain Res Bull 62:223\u2013229","journal-title":"Brain Res Bull"},{"key":"10941_CR38","doi-asserted-by":"publisher","first-page":"eabn1675","DOI":"10.1126\/sciadv.abn1675","volume":"8","author":"J Jang","year":"2022","unstructured":"Jang J, Park CB (2022) Magnetoelectric dissociation of Alzheimer\u2019s \u03b2-amyloid aggregates. Sci Adv 8:eabn1675","journal-title":"Sci Adv"},{"key":"10941_CR39","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3390\/foods9080985","volume":"9","author":"N Barache","year":"2020","unstructured":"Barache N, Belguesmia Y, Ladjouzi R, Bendali F, Drider D (2020) Clusters of Lactobacillus strains from vegetal origins are associated with beneficial functions: experimental data and statistical interpretations. Foods 9:985","journal-title":"Foods"},{"key":"10941_CR40","doi-asserted-by":"publisher","first-page":"11952","DOI":"10.1038\/s41598-022-16322-z","volume":"12","author":"A Mazlumi","year":"2022","unstructured":"Mazlumi A, Panahi B, Hejazi MA, Nami Y (2022) Probiotic potential characterization and clustering using unsupervised algorithms of lactic acid bacteria from saltwater fish samples. Sci Rep 12:11952","journal-title":"Sci Rep"},{"key":"10941_CR41","doi-asserted-by":"publisher","first-page":"1385301","DOI":"10.3389\/fmicb.2024.1385301","volume":"15","author":"M Moghimani","year":"2024","unstructured":"Moghimani M, Onyeaka H, Hashemi M, Afshari A (2024) Evaluation of the probiotic, technological, safety attributes, and GABA-producing capacity of microorganisms isolated from Iranian milk kefir beverages. Front Microbiol 15:1385301","journal-title":"Front Microbiol"},{"key":"10941_CR42","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3390\/foods10020289","volume":"10","author":"G Di Matteo","year":"2021","unstructured":"Di Matteo G, Spano M, Esposito C, Santarcangelo C, Baldi A, Daglia M, Mannina L, Ingallina C, Sobolev AP (2021) NMR characterization of ten apple cultivars from the Piedmont region. Foods 10:289","journal-title":"Foods"},{"key":"10941_CR43","doi-asserted-by":"publisher","first-page":"122519","DOI":"10.1016\/j.jchromb.2020.122519","volume":"1164","author":"TH de Bie","year":"2021","unstructured":"de Bie TH, Witkamp RF, Jongsma MA, Balvers MGJ (2021) Development and validation of a UPLC-MS\/MS method for the simultaneous determination of gamma-aminobutyric acid and glutamic acid in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 1164:122519","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10941_CR44","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12866-023-02890-1","volume":"23","author":"M Zommara","year":"2023","unstructured":"Zommara M, El-Ghaish S, Haertle T, Chobert J-M, Ghanimah M (2023) Probiotic and technological characterization of selected Lactobacillus strains isolated from different Egyptian cheeses. BMC Microbiol 23:160","journal-title":"BMC Microbiol"},{"key":"10941_CR45","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.3390\/foods10102275","volume":"10","author":"A Hurtado-Romero","year":"2021","unstructured":"Hurtado-Romero A, Toro-Barbosa MD, Gradilla-Hern\u00e1ndez MS, Garcia-Amezquita LE, Garc\u00eda-Cayuela T (2021) Probiotic properties, prebiotic fermentability, and GABA-producing capacity of microorganisms isolated from Mexican milk Kefir grains: a clustering evaluation for functional dairy food applications. Foods 10:2275","journal-title":"Foods"},{"key":"10941_CR46","doi-asserted-by":"publisher","first-page":"109571","DOI":"10.1016\/j.foodres.2020.109571","volume":"136","author":"T Li","year":"2020","unstructured":"Li T, Teng D, Mao R, Hao Y, Wang X, Wang J (2020) A critical review of antibiotic resistance in probiotic bacteria. Food Res Int 136:109571. https:\/\/doi.org\/10.1016\/j.foodres.2020.109571","journal-title":"Food Res Int"},{"key":"10941_CR47","doi-asserted-by":"publisher","first-page":"110327","DOI":"10.1016\/j.lwt.2020.110327","volume":"136","author":"A-N Xia","year":"2021","unstructured":"Xia A-N, Meng X-S, Tang X-J, Zhang Y-Z, Lei S-M, Liu Y-G (2021) Probiotic and related properties of a novel lactic acid bacteria strain isolated from fermented rose jam. LWT 136:110327. https:\/\/doi.org\/10.1016\/j.lwt.2020.110327","journal-title":"LWT"},{"key":"10941_CR48","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s13213-017-1254-6","volume":"67","author":"Y Feng","year":"2017","unstructured":"Feng Y, Qiao L, Liu R, Yao H, Gao C (2017) Potential probiotic properties of lactic acid bacteria isolated from the intestinal mucosa of healthy piglets. Ann Microbiol 67:239\u2013253","journal-title":"Ann Microbiol"},{"key":"10941_CR49","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.bj.2017.06.008","volume":"40","author":"C Prabhurajeshwar","year":"2017","unstructured":"Prabhurajeshwar C, Chandrakanth RK (2017) Probiotic potential of lactobacilli with antagonistic activity against pathogenic strains: an in vitro validation for the production of inhibitory substances. Biomed J 40:270\u2013283","journal-title":"Biomed J"},{"key":"10941_CR50","doi-asserted-by":"publisher","first-page":"323","DOI":"10.2298\/ABS1002323B","volume":"62","author":"H Boke","year":"2010","unstructured":"Boke H, Aslim B, Alp G (2010) The role of resistance to bile salts and acid tolerance of exopolysaccharides (EPSS) produced by yogurt starter bacteria. Arch Biol Sci (Beogr) 62:323\u2013328. https:\/\/doi.org\/10.2298\/ABS1002323B","journal-title":"Arch Biol Sci (Beogr)"},{"key":"10941_CR51","doi-asserted-by":"publisher","first-page":"3902","DOI":"10.1002\/jsfa.10432","volume":"100","author":"S Melchior","year":"2020","unstructured":"Melchior S, Marino M, Innocente N, Calligaris S, Nicoli MC (2020) Effect of different biopolymer-based structured systems on the survival of probiotic strains during storage and in vitro digestion. J Sci Food Agric 100:3902\u20133909","journal-title":"J Sci Food Agric"},{"key":"10941_CR52","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.bej.2009.11.014","volume":"48","author":"K Hori","year":"2010","unstructured":"Hori K, Matsumoto S (2010) Bacterial adhesion: from mechanism to control. Biochem Eng J 48:424\u2013434","journal-title":"Biochem Eng J"},{"key":"10941_CR53","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s00284-017-1285-z","volume":"74","author":"V Santarmaki","year":"2017","unstructured":"Santarmaki V, Kourkoutas Y, Zoumpopoulou G, Mavrogonatou E, Kiourtzidis M, Chorianopoulos N, Tassou C, Tsakalidou E, Simopoulos C, Ypsilantis P (2017) Survival, intestinal mucosa adhesion, and immunomodulatory potential of Lactobacillus plantarum strains. Curr Microbiol 74:1061\u20131067","journal-title":"Curr Microbiol"},{"key":"10941_CR54","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.idairyj.2004.12.008","volume":"15","author":"U Schillinger","year":"2005","unstructured":"Schillinger U, Guigas C, Holzapfel WH (2005) In vitro adherence and other properties of lactobacilli used in probiotic yoghurt-like products. Int Dairy J 15:1289\u20131297. https:\/\/doi.org\/10.1016\/j.idairyj.2004.12.008","journal-title":"Int Dairy J"},{"key":"10941_CR55","doi-asserted-by":"publisher","DOI":"10.1093\/jambio\/lxac005","author":"EK Kanak","year":"2023","unstructured":"Kanak EK, Yilmaz S\u00d6, Altindi\u015f M, Tanriverdi ES, Otlu B (2023) Determination of safety status and probiotic properties of Enterococcus strains isolated from traditional cheeses in Turkey. J Appl Microbiol. https:\/\/doi.org\/10.1093\/jambio\/lxac005","journal-title":"J Appl Microbiol"},{"key":"10941_CR56","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1111\/lam.13794","volume":"75","author":"B Rahmani","year":"2022","unstructured":"Rahmani B, Alimadadi N, Attaran B, Nasr S (2022) Yeasts from Iranian traditional milk Kefir samples: isolation, molecular identification and their potential probiotic properties. Lett Appl Microbiol 75:1264\u20131274","journal-title":"Lett Appl Microbiol"},{"key":"10941_CR57","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3390\/fermentation5040100","volume":"5","author":"G Krausova","year":"2019","unstructured":"Krausova G, Hyrslova I, Hynstova I (2019) In vitro evaluation of adhesion capacity, hydrophobicity, and auto-aggregation of newly isolated potential probiotic strains. Fermentation 5:100. https:\/\/doi.org\/10.3390\/fermentation5040100","journal-title":"Fermentation"},{"key":"10941_CR58","doi-asserted-by":"publisher","first-page":"5092","DOI":"10.1002\/fsn3.2468","volume":"9","author":"W Farid","year":"2021","unstructured":"Farid W, Masud T, Sohail A, Ahmad N, Naqvi SMS, Khan S, Ali A, Khalifa SA, Hussain A, Ali S, Saghir M, Siddeeg A, Manzoor MF (2021) Gastrointestinal transit tolerance, cell surface hydrophobicity, and functional attributes of Lactobacillus acidophilus strains isolated from Indigenous Dahi. Food Sci Nutr 9:5092\u20135102. https:\/\/doi.org\/10.1002\/fsn3.2468","journal-title":"Food Sci Nutr"},{"key":"10941_CR59","doi-asserted-by":"publisher","first-page":"881","DOI":"10.3389\/fmicb.2019.00881","volume":"10","author":"O Baccouri","year":"2019","unstructured":"Baccouri O, Boukerb AM, Farhat LB, Z\u00e9br\u00e9 A, Zimmermann K, Domann E, Cambronel M, Barreau M, Maillot O, Rinc\u00e9 I, Muller C, Marzouki MN, Feuilloley M, Abidi F, Connil N (2019) Probiotic potential and safety evaluation of Enterococcus faecalis OB14 and OB15, isolated from traditional Tunisian Testouri cheese and Rigouta, using physiological and genomic analysis. Front Microbiol 10:881","journal-title":"Front Microbiol"},{"key":"10941_CR60","doi-asserted-by":"publisher","first-page":"105003","DOI":"10.1016\/j.micpath.2021.105003","volume":"157","author":"MA Ozma","year":"2021","unstructured":"Ozma MA, Khodadadi E, Rezaee MA, Kamounah FS, Asgharzadeh M, Ganbarov K, Aghazadeh M, Yousefi M, Pirzadeh T, Kafil HS (2021) Induction of proteome changes involved in biofilm formation of Enterococcus faecalis in response to gentamicin. Microb. Pathog. 157:105003","journal-title":"Microb. Pathog."},{"key":"10941_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1163662","author":"Y Hu","year":"2023","unstructured":"Hu Y, Zhao Y, Jia X, Liu D, Huang X, Wang C, Zhu Y, Yue C, Deng S, Lyu Y (2023) Lactic acid bacteria with a strong antioxidant function isolated from \u201cJiangshui,\u201d pickles, and feces. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2023.1163662","journal-title":"Front Microbiol"},{"key":"10941_CR62","doi-asserted-by":"publisher","first-page":"106181","DOI":"10.1016\/j.fbio.2025.106181","volume":"66","author":"Y Gao","year":"2025","unstructured":"Gao Y, Liang Q, Sun J, Wu X, Song Y, Xu Y, Nie H, Huang J, Mu G (2025) Probiotic potential of lactic acid bacteria with antioxidant properties in modulating health: mechanisms, applications, and future directions. Food Biosci 66:106181. https:\/\/doi.org\/10.1016\/j.fbio.2025.106181","journal-title":"Food Biosci"},{"key":"10941_CR63","doi-asserted-by":"publisher","first-page":"1801944","DOI":"10.1080\/19490976.2020.1801944","volume":"12","author":"T Feng","year":"2020","unstructured":"Feng T, Wang J (2020) Oxidative stress tolerance and antioxidant capacity of lactic acid bacteria as probiotic: a systematic review. Gut Microbes 12:1801944. https:\/\/doi.org\/10.1080\/19490976.2020.1801944","journal-title":"Gut Microbes"},{"key":"10941_CR64","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3920\/BM2019.0040","volume":"10","author":"N Kotowicz","year":"2019","unstructured":"Kotowicz N, Bhardwaj RK, Ferreira WT, Hong HA, Olender A, Ramirez J, Cutting SM (2019) Safety and probiotic evaluation of two Bacillus strains producing antioxidant compounds. Benef Microbes 10:759\u2013771","journal-title":"Benef Microbes"},{"key":"10941_CR65","doi-asserted-by":"publisher","first-page":"6768","DOI":"10.1128\/AEM.01393-07","volume":"73","author":"S Lebeer","year":"2007","unstructured":"Lebeer S, Verhoeven TLA, V\u00e9lez MP, Vanderleyden J, De Keersmaecker SCJ (2007) Impact of environmental and genetic factors on biofilm formation by the probiotic strain Lactobacillus rhamnosus GG. Appl Environ Microbiol 73:6768\u20136775","journal-title":"Appl Environ Microbiol"},{"key":"10941_CR66","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s10571-022-01214-7","volume":"43","author":"H Zhou","year":"2023","unstructured":"Zhou H, Rao Z, Zhang Z, Zhou J (2023) Function of the GABAergic system in diabetic encephalopathy. Cell Mol Neurobiol 43:605\u2013619. https:\/\/doi.org\/10.1007\/s10571-022-01214-7","journal-title":"Cell Mol Neurobiol"},{"key":"10941_CR67","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1186\/s12866-025-04070-9","volume":"25","author":"X Bai","year":"2025","unstructured":"Bai X, Shi P, Chu W (2025) Probiotic attributes, antioxidant and neuromodulatory effects of GABA-producing Lactiplantibacillus plantarum SY1 and optimization of GABA production. BMC Microbiol 25:341. https:\/\/doi.org\/10.1186\/s12866-025-04070-9","journal-title":"BMC Microbiol"},{"key":"10941_CR68","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.610016","author":"PG Cataldo","year":"2020","unstructured":"Cataldo PG, Villena J, Elean M, de Savoy Giori G, Saavedra L, Hebert EM (2020) Immunomodulatory properties of a \u03b3-aminobutyric acid-enriched strawberry juice produced by Levilactobacillus brevis CRL 2013. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2020.610016","journal-title":"Front Microbiol"},{"key":"10941_CR69","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.897056","author":"L Bay\u00f3n-Cordero","year":"2022","unstructured":"Bay\u00f3n-Cordero L, Ochoa-Bueno BI, Ruiz A, Ozalla M, Matute C, S\u00e1nchez-G\u00f3mez MV (2022) GABA receptor agonists protect from excitotoxic damage induced by AMPA in oligodendrocytes. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2022.897056","journal-title":"Front Pharmacol"},{"key":"10941_CR70","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.seizure.2021.06.028","volume":"91","author":"GL Sarlo","year":"2021","unstructured":"Sarlo GL, Holton KF (2021) Brain concentrations of glutamate and GABA in human epilepsy: a review. Seizure 91:213\u2013227. https:\/\/doi.org\/10.1016\/j.seizure.2021.06.028","journal-title":"Seizure"},{"key":"10941_CR71","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.brainres.2005.01.058","volume":"1038","author":"H Wu","year":"2005","unstructured":"Wu H, Jin Y, Wei J, Jin H, Sha D, Wu J-Y (2005) Mode of action of taurine as a neuroprotector. Brain Res 1038:123\u2013131. https:\/\/doi.org\/10.1016\/j.brainres.2005.01.058","journal-title":"Brain Res"},{"key":"10941_CR72","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","volume":"108","author":"JA Bravo","year":"2011","unstructured":"Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A 108:16050\u201316055","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10941_CR73","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.neuroimage.2015.11.018","volume":"125","author":"R Janik","year":"2016","unstructured":"Janik R, Thomason LAM, Stanisz AM, Forsythe P, Bienenstock J, Stanisz GJ (2016) Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate. Neuroimage 125:988\u2013995. https:\/\/doi.org\/10.1016\/j.neuroimage.2015.11.018","journal-title":"Neuroimage"},{"key":"10941_CR74","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bbi.2024.08.029","volume":"122","author":"M Casertano","year":"2024","unstructured":"Casertano M, Dekker M, Valentino V, De Filippis F, Fogliano V, Ercolini D (2024) GABA-producing lactobacilli boost cognitive reactivity to negative mood without improving cognitive performance: a human double-blind placebo-controlled cross-over study. Brain Behav Immun 122:256\u2013265","journal-title":"Brain Behav Immun"},{"key":"10941_CR75","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1080\/10408398.2017.1377684","volume":"59","author":"H Liu","year":"2019","unstructured":"Liu H, Cui SW, Chen M, Li Y, Liang R, Xu F, Zhong F (2019) Protective approaches and mechanisms of microencapsulation to the survival of probiotic bacteria during processing, storage and gastrointestinal digestion: a review. Crit Rev Food Sci Nutr 59:2863\u20132878","journal-title":"Crit Rev Food Sci Nutr"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-10941-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-026-10941-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-10941-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:02:41Z","timestamp":1784059361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-026-10941-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10941"],"URL":"https:\/\/doi.org\/10.1007\/s12602-026-10941-y","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]},"assertion":[{"value":"13 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not Applicable.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}