{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:40:01Z","timestamp":1792928401590,"version":"4.5.0"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Reform and Development project of Beijing Academy of Agriculture and Forestry Science","award":["XMS202616"],"award-info":[{"award-number":["XMS202616"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32202679"],"award-info":[{"award-number":["32202679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the R&D Foundation of Institute of Animal Husbandry and Veterinary Medicine, BAAFS","award":["XMS202515"],"award-info":[{"award-number":["XMS202515"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics & Antimicro. Prot."],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s12602-026-10960-9","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:48:50Z","timestamp":1775447330000},"page":"8414-8427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional Integration of Crosstalk Between\u2002Probiotic Lactic Acid Bacteria and Intestinal Immunity Signaling"],"prefix":"10.1007","volume":"18","author":[{"given":"Yuxin","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuzhou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"issue":"3","key":"10960_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nri.2015.17","volume":"16","author":"A Perez-Lopez","year":"2016","unstructured":"Perez-Lopez A, Behnsen J, Nuccio SP, Raffatellu M (2016) Mucosal immunity to pathogenic intestinal bacteria. Nat Rev Immunol 16(3):135\u2013148","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10960_CR2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41385-020-00365-4","volume":"14","author":"F Malard","year":"2021","unstructured":"Malard F, Dore J, Gaugler B, Mohty M (2021) Introduction to host microbiome symbiosis in health and disease. Mucosal Immunol 14(3):547\u2013554","journal-title":"Mucosal Immunol"},{"issue":"4","key":"10960_CR3","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1128\/MMBR.00017-08","volume":"72","author":"S Lebeer","year":"2008","unstructured":"Lebeer S, Vanderleyden J, De Keersmaecker SC (2008) Genes and molecules of Lactobacilli supporting probiotic action. Microbiol Mol Biol Rev 72(4):728\u2013764","journal-title":"Microbiol Mol Biol Rev"},{"issue":"Suppl 1","key":"10960_CR4","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1097\/MCG.0000000000000231","volume":"48","author":"A Cicenia","year":"2014","unstructured":"Cicenia A, Scirocco A, Carabotti M, Pallotta L, Marignani M, Severi C (2014) Postbiotic activities of Lactobacilli-derived factors. J Clin Gastroenterol 48(Suppl 1):S18\u2013S22","journal-title":"J Clin Gastroenterol"},{"issue":"5","key":"10960_CR5","doi-asserted-by":"publisher","first-page":"468","DOI":"10.4161\/gmic.21417","volume":"3","author":"EF O\u2019 Shea","year":"2012","unstructured":"O\u2019 Shea EF, O\u2019 Connor PM, Raftis EJ et al (2012) Subspecies diversity in bacteriocin production by intestinal Lactobacillus salivarius strains. Gut Microbes 3(5):468\u2013473","journal-title":"Gut Microbes"},{"issue":"12","key":"10960_CR6","doi-asserted-by":"publisher","first-page":"e634","DOI":"10.1002\/ctm2.634","volume":"11","author":"JS Yu","year":"2021","unstructured":"Yu JS, Youn GS, Choi J et al (2021) Lactobacillus lactis and pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease. Clin Transl Med 11(12):e634","journal-title":"Clin Transl Med"},{"issue":"1","key":"10960_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbiosc.2022.10.010","volume":"135","author":"LAK Saleena","year":"2023","unstructured":"Saleena LAK, Teo MYM, How YH, In LLA, Pui LP (2023) Immunomodulatory action of Lactococcuslactis. J Biosci Bioeng 135(1):1\u20139","journal-title":"J Biosci Bioeng"},{"key":"10960_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/bs.ai.2020.02.002","volume":"146","author":"RL Fine","year":"2020","unstructured":"Fine RL, Mubiru DL, Kriegel MA (2020) Friend or foe? Lactobacillus in the context of autoimmune disease. Adv Immunol 146:29\u201356","journal-title":"Adv Immunol"},{"issue":"3","key":"10960_CR9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/jgh.14868","volume":"35","author":"CT Zorron","year":"2020","unstructured":"Zorron CT, Pu L, Yamamoto K, Honda T et al (2020) Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon. J Gastroenterol Hepatol 35(3):433\u2013437","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10960_CR10","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12951-025-03280-7","volume":"23","author":"Y Wu","year":"2025","unstructured":"Wu Y, Huang X, Li Q et al (2025) Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release. J Nanobiotechnol 23(1):227","journal-title":"J Nanobiotechnol"},{"issue":"3","key":"10960_CR11","doi-asserted-by":"publisher","first-page":"243","DOI":"10.2169\/internalmedicine.54.2710","volume":"54","author":"B Tiequn","year":"2015","unstructured":"Tiequn B, Guanqun C, Shuo Z (2015) Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis. Intern Med 54(3):243\u2013249","journal-title":"Intern Med"},{"issue":"12","key":"10960_CR12","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1136\/gutjnl-2023-329543","volume":"72","author":"W Fong","year":"2023","unstructured":"Fong W, Li Q, Ji F et al (2023) Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1\/Kyn\/AHR axis. Gut 72(12):2272\u20132285","journal-title":"Gut"},{"issue":"1","key":"10960_CR13","doi-asserted-by":"publisher","first-page":"2430541","DOI":"10.1080\/19490976.2024.2430541","volume":"16","author":"LL Pan","year":"2024","unstructured":"Pan LL, Sun Y, Dong X et al (2024) Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production. Gut Microbes 16(1):2430541","journal-title":"Gut Microbes"},{"issue":"5","key":"10960_CR14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"JL Round","year":"2009","unstructured":"Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313\u2013323","journal-title":"Nat Rev Immunol"},{"key":"10960_CR15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3389\/fimmu.2020.00575","volume":"11","author":"B Zhou","year":"2020","unstructured":"Zhou B, Yuan Y, Zhang S et al (2020) Intestinal flora and disease mutually shape the regional immune system in the intestinal tract. Front Immunol 11:575","journal-title":"Front Immunol"},{"issue":"3","key":"10960_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/jgh.13499","volume":"32","author":"CC Wong","year":"2017","unstructured":"Wong CC, Zhang L, Wu WK et al (2017) Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis. J Gastroenterol Hepatol 32(3):609\u2013619","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"10960_CR17","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s12602-019-09574-1","volume":"12","author":"JS Zhang","year":"2020","unstructured":"Zhang JS, Corredig M, Morales-Rayas R, Hassan A, Griffiths MW, LaPointe G (2020) Downregulation of Salmonella virulence gene expression during invasion of epithelial cells treated with Lactococcus lactis subsp. cremoris JFR1 requires OppA. Probiotics Antimicrob Proteins 12(2):577\u2013588","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"10960_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02904-8","volume":"22","author":"M Yang","year":"2024","unstructured":"Yang M, Gu K, Xu Q et al (2024) Recombinant lactococcus lactis secreting FliC protein nanobodies for resistance against Salmonella enteritidis invasion in the intestinal tract. J Nanobiotechnology 22(1):629","journal-title":"J Nanobiotechnology"},{"issue":"10","key":"10960_CR19","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.imbio.2015.06.004","volume":"220","author":"C Iraporda","year":"2015","unstructured":"Iraporda C, Errea A, Romanin DE et al (2015) Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells. Immunobiology 220(10):1161\u20131169","journal-title":"Immunobiology"},{"issue":"6","key":"10960_CR20","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.chom.2018.11.002","volume":"24","author":"YS Lee","year":"2018","unstructured":"Lee YS, Kim TY, Kim Y et al (2018) Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development. Cell Host Microbe 24(6):833\u2013846e6","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10960_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/nu16050582","volume":"16","author":"X Li","year":"2024","unstructured":"Li X, Yao Z, Qian J, Li H, Li H (2024) Lactate protects intestinal epithelial barrier function from dextran sulfate sodium-induced damage by GPR81 signaling. Nutrients 16(5):582","journal-title":"Nutrients"},{"issue":"5","key":"10960_CR22","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.4049\/jimmunol.1700604","volume":"200","author":"P Ranganathan","year":"2018","unstructured":"Ranganathan P, Shanmugam A, Swafford D et al (2018) GPR81, a cell-surface receptor for lactate, regulates intestinal homeostasis and protects mice from experimental colitis. J Immunol 200(5):1781\u20131789","journal-title":"J Immunol"},{"issue":"3","key":"10960_CR23","doi-asserted-by":"publisher","first-page":"G506","DOI":"10.1152\/ajpgi.90553.2008","volume":"297","author":"T Watanabe","year":"2009","unstructured":"Watanabe T, Nishio H, Tanigawa T et al (2009) Probiotic Lactobacillus casei strain shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. Am J Physiol Gastrointest Liver Physiol 297(3):G506\u2013G513","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"33","key":"10960_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400058","volume":"11","author":"H Wu","year":"2024","unstructured":"Wu H, Mu C, Li X, Fan W, Shen L, Zhu W (2024) Breed-driven microbiome heterogeneity regulates intestinal stem cell proliferation via Lactobacillus-lactate-GPR81 signaling. Adv Sci 11(33):e2400058","journal-title":"Adv Sci"},{"issue":"5","key":"10960_CR25","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1039\/D1FO03360C","volume":"13","author":"P Li","year":"2022","unstructured":"Li P, Chen G, Zhang J et al (2022) Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs\/mitophagy\/NLRP3 inflammasome axis. Food Funct 13(5):2985\u20132997","journal-title":"Food Funct"},{"issue":"5","key":"10960_CR26","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1007\/s12602-024-10243-1","volume":"17","author":"MJ Sun","year":"2025","unstructured":"Sun MJ, Xing JH, Yan QS et al (2025) The acetic acid produced by Lactobacillus regulates immune function to alleviate PEDV infection in piglets. Probiotics Antimicrob Proteins 17(5):2962\u20132979","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"10960_CR27","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s41467-023-36323-4","volume":"14","author":"J Niu","year":"2023","unstructured":"Niu J, Cui M, Yang X et al (2023) Microbiota-derived acetate enhances host antiviral response via NLRP3. Nat Commun 14(1):642","journal-title":"Nat Commun"},{"issue":"1","key":"10960_CR28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/hep.32449","volume":"77","author":"C Hu","year":"2023","unstructured":"Hu C, Xu B, Wang X et al (2023) Gut microbiota-derived short-chain fatty acids regulate group 3 innate lymphoid cells in HCC. Hepatology 77(1):48\u201364","journal-title":"Hepatology"},{"key":"10960_CR29","doi-asserted-by":"publisher","first-page":"1103836","DOI":"10.3389\/fmicb.2022.1103836","volume":"13","author":"V Singh","year":"2023","unstructured":"Singh V, Lee G, Son H et al (2023) Butyrate producers, The Sentinel of Gut: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics. Front Microbiol 13:1103836","journal-title":"Front Microbiol"},{"issue":"2","key":"10960_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020727","volume":"25","author":"H Bao","year":"2024","unstructured":"Bao H, Wang Y, Xiong H, Xia Y, Cui Z, Liu L (2024) Mechanism of iron ion homeostasis in intestinal immunity and gut microbiota remodeling. Int J Mol Sci 25(2):727","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10960_CR31","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1007\/s12602-025-10475-9","volume":"17","author":"MO Cristina","year":"2025","unstructured":"Cristina MO, Elizabeth BR, Jose RM, Berenice PG, Diego Z, Luis CJ (2025) Mechanisms and therapeutic potential of key anti-inflammatory metabiotics: trans-Vaccenic Acid, Indole-3-Lactic Acid, Thiamine, and Butyric Acid. Probiotics Antimicrob Proteins 17(5):2805\u20132818","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"12","key":"10960_CR32","doi-asserted-by":"publisher","first-page":"104280","DOI":"10.1016\/j.psj.2024.104280","volume":"103","author":"X Xiao","year":"2024","unstructured":"Xiao X, Cui T, Qin S et al (2024) Beneficial effects of Lactobacillus plantarum on growth performance, immune status, antioxidant function and intestinal microbiota in broilers. Poult Sci 103(12):104280","journal-title":"Poult Sci"},{"key":"10960_CR33","doi-asserted-by":"publisher","first-page":"706148","DOI":"10.3389\/fnut.2021.706148","volume":"8","author":"B Wang","year":"2021","unstructured":"Wang B, Zhou Y, Mao Y et al (2021) Dietary supplementation with Lactobacillus plantarum ameliorates compromise of growth performance by modulating short-chain fatty acids and intestinal dysbiosis in broilers under Clostridium perfringens challenge. Front Nutr 8:706148","journal-title":"Front Nutr"},{"issue":"1","key":"10960_CR34","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/bph.16219","volume":"181","author":"H Miao","year":"2024","unstructured":"Miao H, Wang YN, Yu XY et al (2024) Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan-produced indole metabolites. Br J Pharmacol 181(1):162\u2013179","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10960_CR35","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1007\/s12602-024-10338-9","volume":"16","author":"G He","year":"2024","unstructured":"He G, Long H, He J, Zhu C (2024) The immunomodulatory effects and applications of probiotic Lactiplantibacillus plantarum in vaccine development. Probiotics Antimicrob Proteins 16(6):2229\u20132250","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"3","key":"10960_CR36","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1080\/08830185.2021.1954638","volume":"41","author":"M Ala","year":"2022","unstructured":"Ala M (2022) Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. Int Rev Immunol 41(3):326\u2013345","journal-title":"Int Rev Immunol"},{"issue":"8","key":"10960_CR37","doi-asserted-by":"publisher","first-page":"e0103924","DOI":"10.1128\/jvi.01039-24","volume":"98","author":"J Wang","year":"2024","unstructured":"Wang J, Zhao Y, Cui T et al (2024) AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection. J Virol 98(8):e0103924","journal-title":"J Virol"},{"issue":"5","key":"10960_CR38","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1021\/acs.jafc.0c05205","volume":"69","author":"J Li","year":"2021","unstructured":"Li J, Zhang L, Wu T, Li Y, Zhou X, Ruan Z (2021) Indole-3-propionic acid improved the intestinal barrier by enhancing epithelial barrier and mucus barrier. J Agric Food Chem 69(5):1487\u20131495","journal-title":"J Agric Food Chem"},{"issue":"7","key":"10960_CR39","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/j.cell.2024.02.022","volume":"187","author":"D Jia","year":"2024","unstructured":"Jia D, Wang Q, Qi Y et al (2024) Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell 187(7):1651\u20131665e21","journal-title":"Cell"},{"issue":"9","key":"10960_CR40","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/j.cell.2023.03.022","volume":"186","author":"MS Pereira","year":"2023","unstructured":"Pereira MS, Kriegel MA (2023) Translocating Lactobacillus torments tumors via tryptophan catabolism. Cell 186(9):1821\u20131823","journal-title":"Cell"},{"issue":"1","key":"10960_CR41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12934-025-02662-8","volume":"24","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Zheng K, Zhang Z et al (2025) Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor. Microb Cell Fact 24(1):34","journal-title":"Microb Cell Fact"},{"issue":"6","key":"10960_CR42","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.cmet.2023.04.015","volume":"35","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Zhao Q, Li T et al (2023) Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity. Cell Metab 35(6):943\u2013960e9","journal-title":"Cell Metab"},{"issue":"1","key":"10960_CR43","doi-asserted-by":"publisher","first-page":"e24093","DOI":"10.1002\/jcla.24093","volume":"36","author":"A Darbandi","year":"2022","unstructured":"Darbandi A, Asadi A, Mahdizade Ari M et al (2022) Bacteriocins: Properties and potential use as antimicrobials. J Clin Lab Anal 36(1):e24093","journal-title":"J Clin Lab Anal"},{"issue":"6","key":"10960_CR44","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1111\/1750-3841.16148","volume":"87","author":"YM Zhang","year":"2022","unstructured":"Zhang YM, Jiang YH, Li HW, Li XZ, Zhang QL (2022) Purification and characterization of Lactobacillus plantarum-derived bacteriocin with activity against Staphylococcus argenteus planktonic cells and biofilm. J Food Sci 87(6):2718\u20132731","journal-title":"J Food Sci"},{"issue":"3","key":"10960_CR45","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.3168\/jds.2021-21126","volume":"105","author":"YH Jiang","year":"2022","unstructured":"Jiang YH, Xin WG, Yang LY et al (2022) A novel bacteriocin against Staphylococcus aureus from Lactobacillus paracasei isolated from Yunnan traditional fermented yogurt: Purification, antibacterial characterization, and antibiofilm activity. J Dairy Sci 105(3):2094\u20132107","journal-title":"J Dairy Sci"},{"key":"10960_CR46","doi-asserted-by":"publisher","first-page":"710862","DOI":"10.3389\/fnut.2021.710862","volume":"8","author":"M Dai","year":"2021","unstructured":"Dai M, Li Y, Xu L et al (2021) A Novel Bacteriocin from Lactobacillus Pentosus ZFM94 and its antibacterial mode of action. Front Nutr 8:710862","journal-title":"Front Nutr"},{"issue":"5","key":"10960_CR47","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1111\/1750-3841.15131","volume":"85","author":"Y Lu","year":"2020","unstructured":"Lu Y, Yan H, Li X et al (2020) Physicochemical properties and mode of action of a novel bacteriocin BM1122 with broad antibacterial spectrum produced by Lactobacillus crustorum MN047. J Food Sci 85(5):1523\u20131535","journal-title":"J Food Sci"},{"issue":"6","key":"10960_CR48","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.chom.2018.11.006","volume":"24","author":"J Hu","year":"2018","unstructured":"Hu J, Ma L, Nie Y et al (2018) A microbiota-derived bacteriocin targets the host to confer diarrhea resistance in early-weaned piglets. Cell Host Microbe 24(6):817\u2013832e8","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10960_CR49","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1080\/19490976.2018.1534513","volume":"10","author":"DD Heeney","year":"2019","unstructured":"Heeney DD, Zhai Z, Bendiks Z et al (2019) Lactobacillus plantarum bacteriocin is associated with intestinal and systemic improvements in diet-induced obese mice and maintains epithelial barrier integrity in vitro. Gut Microbes 10(3):382\u2013397","journal-title":"Gut Microbes"},{"issue":"2","key":"10960_CR50","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3920\/BM2017.0096","volume":"9","author":"X Yin","year":"2018","unstructured":"Yin X, Heeney D, Srisengfa Y, Golomb B, Griffey S, Marco M (2018) Bacteriocin biosynthesis contributes to the anti-inflammatory capacities of probiotic Lactobacillus plantarum. Benef Microbes 9(2):333\u2013344","journal-title":"Benef Microbes"},{"issue":"9","key":"10960_CR51","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1007\/s00253-020-10493-3","volume":"104","author":"E Garcia-Gutierrez","year":"2020","unstructured":"Garcia-Gutierrez E, O\u2019Connor PM, Colquhoun IJ et al (2020) Production of multiple bacteriocins, including the novel bacteriocin gassericin M, by Lactobacillus gasseri LM19, a strain isolated from human milk. Appl Microbiol Biotechnol 104(9):3869\u20133884","journal-title":"Appl Microbiol Biotechnol"},{"key":"10960_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1266510","volume":"15","author":"R Liu","year":"2024","unstructured":"Liu R (2024) A promising area of research in medicine: recent advances in properties and applications of Lactobacillus-derived exosomes. Front Microbiol 15:1266510","journal-title":"Front Microbiol"},{"issue":"1","key":"10960_CR53","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12934-022-01812-6","volume":"21","author":"L Liang","year":"2022","unstructured":"Liang L, Yang C, Liu L et al (2022) Commensal bacteria-derived extracellular vesicles suppress ulcerative colitis through regulating the macrophages polarization and remodeling the gut microbiota. Microb Cell Fact 21(1):88","journal-title":"Microb Cell Fact"},{"issue":"1","key":"10960_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17629-7","volume":"12","author":"A Kurata","year":"2022","unstructured":"Kurata A, Kiyohara S, Imai T et al (2022) Characterization of extracellular vesicles from Lactiplantibacillus plantarum. Sci Rep 12(1):13330","journal-title":"Sci Rep"},{"key":"10960_CR55","doi-asserted-by":"publisher","first-page":"1459213","DOI":"10.3389\/fimmu.2024.1459213","volume":"15","author":"S Gong","year":"2024","unstructured":"Gong S, Zeng R, Liu L et al (2024) Extracellular vesicles from a novel Lactiplantibacillus plantarum strain suppress inflammation and promote M2 macrophage polarization. Front Immunol 15:1459213","journal-title":"Front Immunol"},{"issue":"1","key":"10960_CR56","doi-asserted-by":"publisher","first-page":"1793514","DOI":"10.1080\/20013078.2020.1793514","volume":"9","author":"W Kim","year":"2020","unstructured":"Kim W, Lee EJ, Bae IH et al (2020) Lactobacillus plantarum-derived extracellular vesicles induce anti-inflammatory M2 macrophage polarization in vitro. J Extracell Vesicles 9(1):1793514","journal-title":"J Extracell Vesicles"},{"key":"10960_CR57","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jare.2024.03.011","volume":"69","author":"S Tao","year":"2025","unstructured":"Tao S, Fan J, Li J et al (2025) Extracellular vesicles derived from Lactobacillus johnsonii promote gut barrier homeostasis by enhancing M2 macrophage polarization. J Adv Res 69:545\u2013563","journal-title":"J Adv Res"},{"issue":"10","key":"10960_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103319","volume":"13","author":"L Tong","year":"2021","unstructured":"Tong L, Zhang X, Hao H et al (2021) Lactobacillus rhamnosus GG derived extracellular vesicles modulate gut microbiota and attenuate inflammatory in DSS-induced colitis mice. Nutrients 13(10):3319","journal-title":"Nutrients"},{"issue":"3","key":"10960_CR59","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s12276-019-0359-3","volume":"52","author":"JH Choi","year":"2020","unstructured":"Choi JH, Moon CM, Shin TS et al (2020) Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway. Exp Mol Med 52(3):423\u2013437","journal-title":"Exp Mol Med"},{"issue":"3","key":"10960_CR60","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.gtc.2005.05.011","volume":"34","author":"S Doron","year":"2005","unstructured":"Doron S, Snydman DR, Gorbach SL (2005) Lactobacillus GG: bacteriology and clinical applications. Gastroenterol Clin North Am 34(3):483","journal-title":"Gastroenterol Clin North Am"},{"issue":"1","key":"10960_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37120-6","volume":"9","author":"SN Dean","year":"2019","unstructured":"Dean SN, Leary DH, Sullivan CJ, Oh E, Walper SA (2019) Isolation and characterization of Lactobacillus-derived membrane vesicles. Sci Rep 9(1):877","journal-title":"Sci Rep"},{"issue":"2","key":"10960_CR62","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1177\/09680519050110020601","volume":"11","author":"D Mengin-Lecreulx","year":"2005","unstructured":"Mengin-Lecreulx D, Lemaitre B (2005) Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system. J Endotoxin Res 11(2):105\u2013111","journal-title":"J Endotoxin Res"},{"issue":"15","key":"10960_CR63","doi-asserted-by":"publisher","first-page":"8581","DOI":"10.1021\/acs.jafc.4c00460","volume":"72","author":"J Li","year":"2024","unstructured":"Li J, Yu J, Song Y, Wang S, Mu G, Tuo Y (2024) Exopolysaccharides and surface-layer proteins expressed by biofilm-state Lactiplantibacillus plantarum Y42 play crucial role in preventing intestinal barrier and immunity dysfunction of Balb\/C Mice Infected by Listeria monocytogenes ATCC 19115. J Agric Food Chem 72(15):8581\u20138594","journal-title":"J Agric Food Chem"},{"issue":"Pt 3","key":"10960_CR64","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.semcancer.2021.12.013","volume":"86","author":"K Garbacz","year":"2022","unstructured":"Garbacz K (2022) Anticancer activity of lactic acid bacteria. Semin Cancer Biol 86(Pt 3):356\u2013366","journal-title":"Semin Cancer Biol"},{"key":"10960_CR65","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.carbpol.2015.04.026","volume":"128","author":"Z Wu","year":"2015","unstructured":"Wu Z, Pan D, Guo Y, Sun Y, Zeng X (2015) Peptidoglycan diversity and anti-inflammatory capacity in Lactobacillus strains. Carbohydr Polym 128:130\u2013137","journal-title":"Carbohydr Polym"},{"issue":"2","key":"10960_CR66","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.carbpol.2013.04.028","volume":"96","author":"Z Wu","year":"2013","unstructured":"Wu Z, Pan DD, Guo Y, Zeng X (2013) Structure and anti-inflammatory capacity of peptidoglycan from Lactobacillus acidophilus in RAW-264.7 cells. Carbohydr Polym 96(2):466\u2013473","journal-title":"Carbohydr Polym"},{"issue":"4","key":"10960_CR67","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1021\/acscentsci.1c00200","volume":"7","author":"KL Bersch","year":"2021","unstructured":"Bersch KL, DeMeester KE, Zagani R et al (2021) Bacterial peptidoglycan fragments differentially regulate innate immune signaling. ACS Cent Sci 7(4):688\u2013696","journal-title":"ACS Cent Sci"},{"issue":"12","key":"10960_CR68","doi-asserted-by":"publisher","first-page":"10148","DOI":"10.1002\/fsn3.4517","volume":"12","author":"Z Meng","year":"2024","unstructured":"Meng Z, Huang X, Qiao M, Song L, Liu Y, Hai D (2024) Lactic acid bacteria surface proteins in the mechanisms of cell adhesion and immunoregulation. Food Sci Nutr 12(12):10148\u201310163","journal-title":"Food Sci Nutr"},{"issue":"6","key":"10960_CR69","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.2741\/3843","volume":"16","author":"Z Liu","year":"2011","unstructured":"Liu Z, Shen T, Moyer MP, Qin H (2011) Identification of the Lactobacillus SLP domain that binds gastric mucin. Front Biosci (Landmark Ed) 16(6):2128\u20132143","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10960_CR70","doi-asserted-by":"publisher","first-page":"125146","DOI":"10.1016\/j.ijbiomac.2023.125146","volume":"244","author":"R Choudhary","year":"2023","unstructured":"Choudhary R, Singh KS, Bisht S et al (2023) Host-microbe interaction and pathogen exclusion mediated by an aggregation-prone surface layer protein of Lactobacillus helveticus. Int J Biol Macromol 244:125146","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"10960_CR71","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ijfoodmicro.2006.11.007","volume":"115","author":"X Chen","year":"2007","unstructured":"Chen X, Xu J, Shuai J, Chen J, Zhang Z, Fang W (2007) The S-layer proteins of Lactobacillus crispatus strain ZJ001 is responsible for competitive exclusion against Escherichia coli O157:H7 and Salmonella typhimurium. Int J Food Microbiol 115(3):307\u2013312","journal-title":"Int J Food Microbiol"},{"key":"10960_CR72","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.ijbiomac.2016.12.085","volume":"96","author":"J Meng","year":"2017","unstructured":"Meng J, Zhang QX, Lu RR (2017) Surface layer protein from Lactobacillus acidophilus NCFM inhibit intestinal pathogen-induced apoptosis in HT-29 cells. Int J Biol Macromol 96:766\u2013774","journal-title":"Int J Biol Macromol"},{"key":"10960_CR73","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.vetmic.2019.01.003","volume":"229","author":"X Zhang","year":"2019","unstructured":"Zhang X, Li P, Zheng Q, Hou J (2019) Lactobacillus acidophilus S-layer protein-mediated inhibition of PEDV-induced apoptosis of Vero cells. Vet Microbiol 229:159\u2013167","journal-title":"Vet Microbiol"},{"issue":"21","key":"10960_CR74","doi-asserted-by":"publisher","first-page":"11008","DOI":"10.1039\/D2FO00001F","volume":"13","author":"X Zhang","year":"2022","unstructured":"Zhang X, Li Y, Zhang C et al (2022) Postbiotics derived from Lactobacillus plantarum 1.0386 ameliorate lipopolysaccharide-induced tight junction injury via MicroRNA-200c-3p mediated activation of the MLCK-MLC pathway in Caco-2 cells. Food Funct 13(21):11008\u201311020","journal-title":"Food Funct"},{"issue":"6","key":"10960_CR75","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-023-03610-7","volume":"39","author":"Y Yang","year":"2023","unstructured":"Yang Y, Jiang G, Tian Y (2023) Biological activities and applications of exopolysaccharides produced by lactic acid bacteria: a mini-review. World J Microbiol Biotechnol 39(6):155","journal-title":"World J Microbiol Biotechnol"},{"issue":"4","key":"10960_CR76","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad046","volume":"47","author":"CG Lee","year":"2023","unstructured":"Lee CG, Cha KH, Kim GC, Im SH, Kwon HK (2023) Exploring probiotic effector molecules and their mode of action in gut-immune interactions. FEMS Microbiol Rev 47(4):fuad046","journal-title":"FEMS Microbiol Rev"},{"key":"10960_CR77","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.aninu.2023.02.004","volume":"13","author":"S Yang","year":"2023","unstructured":"Yang S, Xu X, Peng Q, Ma L, Qiao Y, Shi B (2023) Exopolysaccharides from lactic acid bacteria, as an alternative to antibiotics, on regulation of intestinal health and the immune system. Anim Nutr 13:78\u201389","journal-title":"Anim Nutr"},{"key":"10960_CR78","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.ijbiomac.2020.06.190","volume":"162","author":"J Angelin","year":"2020","unstructured":"Angelin J, Kavitha M (2020) Exopolysaccharides from probiotic bacteria and their health potential. Int J Biol Macromol 162:853\u2013865","journal-title":"Int J Biol Macromol"},{"key":"10960_CR79","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8936907","volume":"2021","author":"J Wang","year":"2021","unstructured":"Wang J, Zhang W, Wang S, Wang Y, Chu X, Ji H (2021) Lactobacillus plantarum exhibits antioxidant and cytoprotective activities in porcine intestinal epithelial cells exposed to hydrogen peroxide. Oxid Med Cell Longev 2021:8936907","journal-title":"Oxid Med Cell Longev"},{"issue":"28","key":"10960_CR80","doi-asserted-by":"publisher","first-page":"7863","DOI":"10.1021\/acs.jafc.1c01898","volume":"69","author":"X Zhou","year":"2021","unstructured":"Zhou X, Zhang D, Qi W et al (2021) Exopolysaccharides from Lactobacillus plantarum NCU116 facilitate intestinal homeostasis by modulating intestinal epithelial regeneration and microbiota. J Agric Food Chem 69(28):7863\u20137873","journal-title":"J Agric Food Chem"},{"key":"10960_CR81","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.carbpol.2019.04.025","volume":"217","author":"Y Rahbar Saadat","year":"2019","unstructured":"Rahbar Saadat Y, Yari Khosroushahi A, Pourghassem Gargari B (2019) A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides. Carbohydr Polym 217:79\u201389","journal-title":"Carbohydr Polym"},{"key":"10960_CR82","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/ar.1091490315","volume":"149","author":"HW Deane","year":"1964","unstructured":"Deane HW (1964) Some electron microscopic observations on the lamina propria of the gut, with comments on the close association of macrophages, plasma cells, and eosinophils. Anat Rec 149:453\u2013473","journal-title":"Anat Rec"},{"key":"10960_CR83","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","volume":"79","author":"PJ Murray","year":"2017","unstructured":"Murray PJ (2017) Macrophage polarization. Annu Rev Physiol 79:541\u2013566","journal-title":"Annu Rev Physiol"},{"key":"10960_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2022.113378","volume":"511","author":"L Liu","year":"2022","unstructured":"Liu L, Stokes JV, Tan W, Pruett SB (2022) An optimized flow cytometry panel for classifying macrophage polarization. J Immunol Methods 511:113378","journal-title":"J Immunol Methods"},{"key":"10960_CR85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1352946","volume":"15","author":"M Luo","year":"2024","unstructured":"Luo M, Zhao F, Cheng H, Su M, Wang Y (2024) Macrophage polarization: an important role in inflammatory diseases. Front Immunol 15:1352946","journal-title":"Front Immunol"},{"issue":"12","key":"10960_CR86","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s00262-017-2052-5","volume":"66","author":"XL Fu","year":"2017","unstructured":"Fu XL, Duan W, Su CY et al (2017) Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression. Cancer Immunol Immunother 66(12):1597\u20131608","journal-title":"Cancer Immunol Immunother"},{"key":"10960_CR87","doi-asserted-by":"publisher","first-page":"127821","DOI":"10.1016\/j.micres.2024.127821","volume":"286","author":"LL Zhang","year":"2024","unstructured":"Zhang LL, Xu JY, Xing Y et al (2024) Lactobacillus rhamnosus GG alleviates radiation-induced intestinal injury by modulating intestinal immunity and remodeling gut microbiota. Microbiol Res 286:127821","journal-title":"Microbiol Res"},{"key":"10960_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104939","volume":"156","author":"B Duan","year":"2021","unstructured":"Duan B, Shao L, Liu R, Msuthwana P, Hu J, Wang C (2021) Lactobacillus rhamnosus GG defense against Salmonella enterica serovar Typhimurium infection through modulation of M1 macrophage polarization. Microb Pathog 156:104939","journal-title":"Microb Pathog"},{"key":"10960_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107541","volume":"211","author":"J Feng","year":"2025","unstructured":"Feng J, Cen Q, Cui Y et al (2025) Lactobacillus rhamnosus: an emerging probiotic with therapeutic potential for depression. Pharmacol Res 211:107541","journal-title":"Pharmacol Res"},{"key":"10960_CR90","doi-asserted-by":"publisher","first-page":"123060","DOI":"10.1016\/j.biomaterials.2024.123060","volume":"317","author":"L Kong","year":"2025","unstructured":"Kong L, Hu X, Xia D et al (2025) Janus PEGylated CuS-engineered Lactobacillus casei combats biofilm infections via metabolic interference and innate immunomodulation. Biomaterials 317:123060","journal-title":"Biomaterials"},{"key":"10960_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113662","volume":"174","author":"F Min","year":"2023","unstructured":"Min F, Hu J, Huang T et al (2023) Effects of Lactobacillus casei NCU011054 on immune response and gut microbiota of cyclophosphamide induced immunosuppression mice. Food Chem Toxicol 174:113662","journal-title":"Food Chem Toxicol"},{"issue":"7","key":"10960_CR92","doi-asserted-by":"publisher","first-page":"e0048424","DOI":"10.1128\/msystems.00484-24","volume":"9","author":"D Li","year":"2024","unstructured":"Li D, Jiang Y, Cui Z et al (2024) Lactobacillus acidophilus protects against Corynebacterium pseudotuberculosis infection by regulating the autophagy of macrophages and maintaining gut microbiota homeostasis in C57BL\/6 mice. mSystems 9(7):e0048424","journal-title":"mSystems"},{"key":"10960_CR93","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1302998","volume":"15","author":"S Deng","year":"2024","unstructured":"Deng S, Pei C, Cai K et al (2024) Lactobacillus acidophilus and its metabolite ursodeoxycholic acid ameliorate ulcerative colitis by promoting Treg differentiation and inhibiting M1 macrophage polarization. Front Microbiol 15:1302998","journal-title":"Front Microbiol"},{"issue":"26","key":"10960_CR94","doi-asserted-by":"publisher","first-page":"14713","DOI":"10.1021\/acs.jafc.4c01758","volume":"72","author":"Q Chen","year":"2024","unstructured":"Chen Q, Fang Z, Yang Z et al (2024) Lactobacillus plantarum-derived extracellular vesicles modulate macrophage polarization and gut homeostasis for alleviating ulcerative colitis. J Agric Food Chem 72(26):14713\u201314726","journal-title":"J Agric Food Chem"},{"key":"10960_CR95","doi-asserted-by":"crossref","unstructured":"Park JY, Yoon HJ, Lee NK, Paik HD (2025) Antioxidant and immunostimulatory effects of Lactobacillus Strains in RAW 264.7 macrophages via NF-\u03baB and MAPK signaling pathways. Probiotics Antimicrob Proteins Published online April 4","DOI":"10.1007\/s12602-025-10526-1"},{"issue":"1","key":"10960_CR96","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1021\/acs.jafc.4c07895","volume":"73","author":"X Zhao","year":"2025","unstructured":"Zhao X, Lin T, Jiang W et al (2025) Lactobacillus helveticus LZ-R-5 ameliorates DSS-induced colitis in mice by modulating gut microbiota and enhancing intestinal barrier function. J Agric Food Chem 73(1):464\u2013477","journal-title":"J Agric Food Chem"},{"key":"10960_CR97","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.622306","volume":"12","author":"UC Kucuksezer","year":"2021","unstructured":"Kucuksezer UC, Aktas Cetin E, Esen F et al (2021) The role of natural killer cells in autoimmune diseases. Front Immunol 12:622306","journal-title":"Front Immunol"},{"issue":"1","key":"10960_CR98","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2470372","volume":"17","author":"Y Liang","year":"2025","unstructured":"Liang Y, Du M, Li X et al (2025) Upregulation of Lactobacillus spp. in gut microbiota as a novel mechanism for environmental eustress-induced anti-pancreatic cancer effects. Gut Microbes 17(1):2470372","journal-title":"Gut Microbes"},{"issue":"1","key":"10960_CR99","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3390\/ijms25010141","volume":"25","author":"C Park","year":"2023","unstructured":"Park C, Ji SY, Hwangbo H et al (2023) Enhancement of immune functions by Limosilactobacillus reuteri KBL346: In yitro and in vivo studies. Int J Mol Sci 25(1):141","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10960_CR100","doi-asserted-by":"publisher","DOI":"10.3390\/nu16091339","volume":"16","author":"GH Hong","year":"2024","unstructured":"Hong GH, Lee SY, Kim IA et al (2024) Effect of heat-treated Lactiplantibacillus plantarum nF1 on the immune system including Natural Killer Cell activity: a randomized, placebo-controlled, double-blind study. Nutrients 16(9):1339","journal-title":"Nutrients"},{"issue":"36","key":"10960_CR101","doi-asserted-by":"publisher","first-page":"e2303457","DOI":"10.1002\/advs.202303457","volume":"10","author":"QW Wang","year":"2023","unstructured":"Wang QW, Jia DJ, He JM et al (2023) Lactobacillus Intestinalis primes epithelial cells to suppress colitis-related Th17 response by host-microbe retinoic acid biosynthesis. Adv Sci (Weinh) 10(36):e2303457","journal-title":"Adv Sci (Weinh)"},{"key":"10960_CR102","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1335975","volume":"15","author":"S Saito","year":"2024","unstructured":"Saito S, Okuno A, Peng Z, Cao DY, Tsuji NM (2024) Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells. Front Immunol 15:1335975","journal-title":"Front Immunol"},{"issue":"1","key":"10960_CR103","doi-asserted-by":"publisher","first-page":"2449111","DOI":"10.1080\/19490976.2024.2449111","volume":"17","author":"Y Sun","year":"2025","unstructured":"Sun Y, Wang Q, Jiang Y et al (2025) Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis. Gut Microbes 17(1):2449111","journal-title":"Gut Microbes"},{"issue":"24","key":"10960_CR104","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.3390\/cells11244133","volume":"11","author":"L Zhu","year":"2022","unstructured":"Zhu L, Liao R, Huang J et al (2022) Lactobacillus salivarius SNK-6 regulates liver lipid metabolism partly via the miR-130a-5p\/MBOAT2 pathway in a NAFLD model of laying hens. Cells 11(24):4133","journal-title":"Cells"},{"issue":"2","key":"10960_CR105","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2252447","volume":"15","author":"AE Cuaycal","year":"2023","unstructured":"Cuaycal AE, Teixeira LD, Lorca GL, Gonzalez CF (2023) Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature. Gut Microbes 15(2):2252447","journal-title":"Gut Microbes"},{"issue":"1","key":"10960_CR106","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01900-7","volume":"22","author":"MB Devi","year":"2024","unstructured":"Devi MB, Bhattacharya A, Kumar A et al (2024) Potential probiotic Lactiplantibacillus plantarum strains alleviate TNF-\u03b1 by regulating ADAM17 protein and ameliorate gut integrity through tight junction protein expression in in vitro model. Cell Commun Signal 22(1):520","journal-title":"Cell Commun Signal"},{"issue":"7975","key":"10960_CR107","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","volume":"620","author":"LM Sanmarco","year":"2023","unstructured":"Sanmarco LM, Rone JM, Polonio CM et al (2023) Lactate limits CNS autoimmunity by stabilizing HIF-1\u03b1 in dendritic cells. Nature 620(7975):881\u2013889","journal-title":"Nature"},{"issue":"5","key":"10960_CR108","doi-asserted-by":"publisher","first-page":"3392","DOI":"10.1007\/s12602-024-10292-6","volume":"17","author":"D Luongo","year":"2025","unstructured":"Luongo D, De Sena V, Maurano F, Rossi M (2025) Modulation of mouse dendritic cells in vitro by Lactobacillus gasseri postbiotic proteins. Probiotics Antimicrob Proteins 17(5):3392\u20133401","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"10960_CR109","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12602-023-10043-z","volume":"16","author":"GC Vale","year":"2024","unstructured":"Vale GC, Mota BIS, Ando-Suguimoto ES, Mayer MPA (2024) Lactobacilli probiotics modulate antibacterial response gene transcription of dendritic cells challenged with LPS. Probiotics Antimicrob Proteins 16(1):293\u2013307","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"10960_CR110","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01687-8","volume":"11","author":"S Kim","year":"2023","unstructured":"Kim S, Lee S, Kim TY, Lee SH, Seo SU, Kweon MN (2023) Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection. Microbiome 11(1):260","journal-title":"Microbiome"},{"key":"10960_CR111","doi-asserted-by":"publisher","first-page":"1395380","DOI":"10.3389\/fimmu.2024.1395380","volume":"15","author":"R Nakagawa","year":"2024","unstructured":"Nakagawa R, Gu W, Mizobuchi H et al (2024) Lactococcus lactis subsp. cremoris YRC3780 modifies function of mesenteric lymph node dendritic cells to modulate the balance of T cell differentiation inducing regulatory T cells. Front Immunol 15:1395380","journal-title":"Front Immunol"},{"issue":"1Suppl 1","key":"10960_CR112","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1186\/1475-2859-10-S1-S17","volume":"10","author":"JM Wells","year":"2011","unstructured":"Wells JM (2011) Immunomodulatory mechanisms of lactobacilli. Microb Cell Fact 10(1Suppl 1):S17","journal-title":"Microb Cell Fact"},{"issue":"3","key":"10960_CR113","doi-asserted-by":"publisher","DOI":"10.3390\/foods12030627","volume":"12","author":"C Yang","year":"2023","unstructured":"Yang C, Zhu J, Bai J et al (2023) Effects of Lactobacillus on the differentiation of intestinal mucosa immune cells and the composition of gut microbiota in soybean-sensitized mice. Foods 12(3):627","journal-title":"Foods"},{"issue":"1","key":"10960_CR114","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2145843","volume":"14","author":"DJ Jia","year":"2022","unstructured":"Jia DJ, Wang QW, Hu YY et al (2022) Lactobacillus johnsonii alleviates colitis by TLR1\/2-STAT3 mediated CD206\u2009+\u2009macrophagesIL-10 activation. Gut Microbes 14(1):2145843","journal-title":"Gut Microbes"},{"key":"10960_CR115","doi-asserted-by":"publisher","first-page":"1195382","DOI":"10.3389\/fimmu.2023.1195382","volume":"14","author":"Y Yin","year":"2023","unstructured":"Yin Y, Liao Y, Li J et al (2023) Lactobacillus plantarum GX17 benefits growth performance and improves functions of intestinal barrier\/intestinal flora among yellow-feathered broilers. Front Immunol 14:1195382","journal-title":"Front Immunol"},{"issue":"14","key":"10960_CR116","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147618","volume":"22","author":"A Saez","year":"2021","unstructured":"Saez A, Gomez-Bris R, Herrero-Fernandez B, Mingorance C, Rius C, Gonzalez-Granado JM (2021) Innate lymphoid cells in intestinal homeostasis and inflammatory bowel disease. Int J Mol Sci 22(14):7618","journal-title":"Int J Mol Sci"},{"issue":"10080","key":"10960_CR117","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","volume":"389","author":"J Torres","year":"2017","unstructured":"Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L (2017) Crohn\u2019s disease. Lancet 389(10080):1741\u20131755","journal-title":"Lancet"},{"issue":"1","key":"10960_CR118","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00535-015-1098-4","volume":"51","author":"R Okamoto","year":"2016","unstructured":"Okamoto R, Watanabe M (2016) Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J Gastroenterol 51(1):11\u201321","journal-title":"J Gastroenterol"},{"issue":"1","key":"10960_CR119","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010121","volume":"26","author":"D Aebisher","year":"2024","unstructured":"Aebisher D, Bartusik-Aebisher D, Przyg\u00f3rzewska A, Ole\u015b P, Wo\u017anicki P, Kawczyk-Krupka A (2024) Key interleukins in inflammatory bowel disease-a review of recent studies. Int J Mol Sci 26(1):121","journal-title":"Int J Mol Sci"},{"key":"10960_CR120","doi-asserted-by":"publisher","first-page":"4810258","DOI":"10.1155\/2017\/4810258","volume":"2017","author":"Q Guan","year":"2017","unstructured":"Guan Q, Zhang J (2017) Recent Advances: The imbalance of cytokines in the pathogenesis of inflammatory bowel disease. Mediators Inflamm 2017:4810258","journal-title":"Mediators Inflamm"},{"issue":"6","key":"10960_CR121","doi-asserted-by":"publisher","first-page":"e13412","DOI":"10.1111\/sji.13412","volume":"100","author":"R Chandwaskar","year":"2024","unstructured":"Chandwaskar R, Dalal R, Gupta S et al (2024) Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease. Scand J Immunol 100(6):e13412","journal-title":"Scand J Immunol"},{"issue":"1","key":"10960_CR122","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00281-014-0454-4","volume":"37","author":"K Matsuoka","year":"2015","unstructured":"Matsuoka K, Kanai T (2015) The gut microbiota and inflammatory bowel disease. Semin Immunopathol 37(1):47\u201355","journal-title":"Semin Immunopathol"},{"issue":"6","key":"10960_CR123","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3748\/wjg.14.845","volume":"14","author":"G De Hertogh","year":"2008","unstructured":"De Hertogh G, Aerssens J, Geboes KP, Geboes K (2008) Evidence for the involvement of infectious agents in the pathogenesis of Crohn\u2019s disease. World J Gastroenterol 14(6):845\u2013852","journal-title":"World J Gastroenterol"},{"key":"10960_CR124","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cimid.2015.10.005","volume":"43","author":"SF \u00d8yri","year":"2015","unstructured":"\u00d8yri SF, M\u0171zes G, Sipos F (2015) Dysbiotic gut microbiome: a key element of Crohn\u2019s disease. Comp Immunol Microbiol Infect Dis 43:36\u201349","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"1","key":"10960_CR125","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1053\/j.gastro.2023.09.019","volume":"166","author":"A Gilliland","year":"2024","unstructured":"Gilliland A, Chan JJ, De Wolfe TJ, Yang H, Vallance BA (2024) Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care. Gastroenterology 166(1):44\u201358","journal-title":"Gastroenterology"},{"key":"10960_CR126","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1286667","volume":"14","author":"D Yan","year":"2023","unstructured":"Yan D, Ye S, He Y et al (2023) Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment. Front Immunol 14:1286667","journal-title":"Front Immunol"},{"issue":"6","key":"10960_CR127","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1007\/s12010-021-03498-9","volume":"193","author":"I Chattopadhyay","year":"2021","unstructured":"Chattopadhyay I, Dhar R, Pethusamy K et al (2021) Exploring the role of gut microbiome in colon cancer. Appl Biochem Biotechnol 193(6):1780\u20131799","journal-title":"Appl Biochem Biotechnol"},{"issue":"1","key":"10960_CR128","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2236364","volume":"15","author":"Z Wang","year":"2023","unstructured":"Wang Z, Dan W, Zhang N, Fang J, Yang Y (2023) Colorectal cancer and gut microbiota studies in China. Gut Microbes 15(1):2236364","journal-title":"Gut Microbes"},{"issue":"3","key":"10960_CR129","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1007\/s13277-013-0684-4","volume":"34","author":"Q Zhu","year":"2013","unstructured":"Zhu Q, Gao R, Wu W, Qin H (2013) The role of gut microbiota in the pathogenesis of colorectal cancer. Tumour Biol 34(3):1285\u20131300","journal-title":"Tumour Biol"},{"key":"10960_CR130","doi-asserted-by":"publisher","first-page":"111828","DOI":"10.1016\/j.nut.2022.111828","volume":"103\u2013104","author":"E Ghorbani","year":"2022","unstructured":"Ghorbani E, Avan A, Ryzhikov M, Ferns G, Khazaei M, Soleimanpour S (2022) Role of lactobacillus strains in the management of colorectal cancer: An overview of recent advances. Nutrition 103\u2013104:111828","journal-title":"Nutrition"},{"issue":"8","key":"10960_CR131","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/sj.bjc.6603990","volume":"97","author":"P Osterlund","year":"2007","unstructured":"Osterlund P, Ruotsalainen T, Korpela R et al (2007) Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer 97(8):1028\u20131034","journal-title":"Br J Cancer"},{"issue":"3","key":"10960_CR132","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1637\/aviandiseases-D-22-00033","volume":"66","author":"V Marcano","year":"2022","unstructured":"Marcano V, Gamble T, Maschek K et al (2022) Necrotizing hepatitis associated with clostridium perfringens in broiler chicks. Avian Dis 66(3):337\u2013344","journal-title":"Avian Dis"},{"key":"10960_CR133","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.874976","volume":"10","author":"AM Campos-Martinez","year":"2022","unstructured":"Campos-Martinez AM, Exp\u00f3sito-Herrera J, Gonzalez-Bol\u00edvar M, Fern\u00e1ndez-Marin E, Uberos J (2022) Evaluation of risk and preventive factors for necrotizing enterocolitis in premature newborns. A systematic review of the literature. Front Pediatr 10:874976","journal-title":"Front Pediatr"},{"key":"10960_CR134","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1095368","volume":"11","author":"KZ Zhou","year":"2023","unstructured":"Zhou KZ, Wu K, Deng LX, Hu M, Luo YX, Zhang LY (2023) Probiotics to prevent necrotizing enterocolitis in very low birth weight infants: a network meta-analysis. Front Pediatr 11:1095368","journal-title":"Front Pediatr"},{"issue":"10","key":"10960_CR135","doi-asserted-by":"publisher","first-page":"e0402523","DOI":"10.1128\/spectrum.04025-23","volume":"12","author":"X-Y Wang","year":"2024","unstructured":"Wang X-Y, Meng F-H, Zhang M-Y et al (2024) Gut Lactococcus garvieae promotes protective immunity to foodborne clostridium perfringens infection. Microbiol Spectr 12(10):e0402523","journal-title":"Microbiol Spectr"},{"issue":"4","key":"10960_CR136","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nrmicro3420","volume":"13","author":"DL LaRock","year":"2015","unstructured":"LaRock DL, Chaudhary A, Miller SI (2015) Salmonellae interactions with host processes. Nat Rev Microbiol 13(4):191\u2013205","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"10960_CR137","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-6-225","volume":"9","author":"GD Ehrlich","year":"2008","unstructured":"Ehrlich GD, Hiller NL, Hu FZ (2008) What makes pathogens pathogenic. Genome Biol 9(6):225","journal-title":"Genome Biol"},{"issue":"8","key":"10960_CR138","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080887","volume":"9","author":"MS Park","year":"2017","unstructured":"Park MS, Kwon B, Ku S, Ji GE (2017) The efficacy of Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 probiotic treatment in infants with Rotavirus infection. Nutrients 9(8):887","journal-title":"Nutrients"},{"issue":"4","key":"10960_CR139","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.4049\/jimmunol.1501705","volume":"196","author":"S Kandasamy","year":"2016","unstructured":"Kandasamy S, Vlasova AN, Fischer D et al (2016) Differential effects of Escherichia coli Nissle and Lactobacillus rhamnosus strain GG on human Rotavirus binding, infection, and B cell immunity. J Immunol 196(4):1780\u20131789","journal-title":"J Immunol"},{"issue":"4","key":"10960_CR140","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tim.2018.01.006","volume":"26","author":"B Chassaing","year":"2018","unstructured":"Chassaing B, Cascales E (2018) Antibacterial weapons: targeted destruction in the microbiota. Trends Microbiol 26(4):329\u2013338","journal-title":"Trends Microbiol"},{"issue":"6408","key":"10960_CR141","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat2456","volume":"361","author":"L Garc\u00eda-Bayona","year":"2018","unstructured":"Garc\u00eda-Bayona L, Comstock LE (2018) Bacterial antagonism in host-associated microbial communities. Science 361(6408):eaat2456","journal-title":"Science"},{"key":"10960_CR142","doi-asserted-by":"publisher","first-page":"128221","DOI":"10.1016\/j.micres.2025.128221","volume":"299","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Sun W, Wu H et al (2025) Receptor-targeted Lactococcus lactis mitigate Clostridioides difficile infection. Microbiol Res 299:128221","journal-title":"Microbiol Res"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-10960-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-026-10960-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-10960-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:01:47Z","timestamp":1787727707000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-026-10960-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":142,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10960"],"URL":"https:\/\/doi.org\/10.1007\/s12602-026-10960-9","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"18 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}