{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:06:09Z","timestamp":1784189169948,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Natural Science Foundation of China under Grant","award":["32172189"],"award-info":[{"award-number":["32172189"]}]},{"name":"College Students' Innovative Entrepreneurial Training Plan Program","award":["JLAU2023-25"],"award-info":[{"award-number":["JLAU2023-25"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"DOI":"10.1007\/s12602-026-11141-4","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:30:44Z","timestamp":1784187044000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heat-Inactivated Lactiplantibacillus plantarum H6 Potentiates Low-Dose Simvastatin Efficacy Against Hypercholesterolemia in Mice Through Gut Microbiota Modulation"],"prefix":"10.1007","author":[{"given":"Yue","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengsheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"3","key":"11141_CR1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3760\/cma.j.cn112148-20230119-00038","volume":"51","author":"Joint Expert Committee for the Revi","year":"2023","unstructured":"Joint Expert Committee for the Revision of China's Lipid Management Guidelines (2023) Chinese guidelines for lipid management (2023). Zhonghua xin xue guan bing za zhi 51(3):221\u2013255. https:\/\/doi.org\/10.3760\/cma.j.cn112148-20230119-00038","journal-title":"Zhonghua xin xue guan bing za zhi"},{"issue":"9","key":"11141_CR2","doi-asserted-by":"publisher","first-page":"e2127573","DOI":"10.1001\/jamanetworkopen.2021.27573","volume":"4","author":"Y Lu","year":"2021","unstructured":"Lu Y, Zhang H, Lu J et al (2021) Prevalence of dyslipidemia and availability of Lipid-Lowering medications among primary health care settings in China. JAMA Netw Open 4(9):e2127573. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.27573","journal-title":"JAMA Netw Open"},{"key":"11141_CR3","doi-asserted-by":"publisher","first-page":"107424842211382","DOI":"10.1177\/10742484221138284","volume":"27","author":"AL Catapano","year":"2022","unstructured":"Catapano AL, Vrablik M, Karpov Y et al (2022) A phase 3 randomized controlled trial to evaluate efficacy and safety of new-formulation zenon (Rosuvastatin\/Ezetimibe Fixed-Dose Combination) in primary hypercholesterolemia inadequately controlled by statins. J Cardiovasc Pharmacol Ther 27:10742484221138284. https:\/\/doi.org\/10.1177\/10742484221138284","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"9","key":"11141_CR4","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","volume":"18","author":"S Salminen","year":"2021","unstructured":"Salminen S, Collado MC, Endo A et al (2021) The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol 18(9):649\u2013667. https:\/\/doi.org\/10.1038\/s41575-021-00440-6","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"11141_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.cmet.2024.03.004","volume":"36","author":"X Zhao","year":"2024","unstructured":"Zhao X, Liu S, Li S et al (2024) Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals. Cell Metab 36(4):725\u2013744. https:\/\/doi.org\/10.1016\/j.cmet.2024.03.004","journal-title":"Cell Metab"},{"issue":"1","key":"11141_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","volume":"19","author":"Y Fan","year":"2021","unstructured":"Fan Y, Pedersen O (2021) Gut microbiota in human metabolic health and disease. Nat Rev Microbiol 19(1):55\u201371. https:\/\/doi.org\/10.1038\/s41579-020-0433-9","journal-title":"Nat Rev Microbiol"},{"issue":"7808","key":"11141_CR7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/s41586-020-2269-x","volume":"581","author":"S Vieira-Silva","year":"2020","unstructured":"Vieira-Silva S, Falony G, Belda E et al (2020) Statin therapy is associated with lower prevalence of gut microbiota dysbiosis. Nature 581(7808):310\u2013315. https:\/\/doi.org\/10.1038\/s41586-020-2269-x","journal-title":"Nature"},{"issue":"7","key":"11141_CR8","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/s41569-020-0396-6","volume":"17","author":"GB Lim","year":"2020","unstructured":"Lim GB (2020) Improved gut microbiota profile in individuals with obesity taking statins. Nat Rev Cardiol 17(7):385. https:\/\/doi.org\/10.1038\/s41569-020-0396-6","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"11141_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s40168-023-01658-z","volume":"11","author":"S Shen","year":"2023","unstructured":"Shen S, Wang J, Ma C et al (2023) Understanding the individual drug reaction from the perspective of the interaction between probiotics and lovastatin in vitro and in vivo. Microbiome 11(1):209. https:\/\/doi.org\/10.1186\/s40168-023-01658-z","journal-title":"Microbiome"},{"key":"11141_CR10","doi-asserted-by":"publisher","first-page":"106716","DOI":"10.1016\/j.prostaglandins.2023.106716","volume":"165","author":"G \u00c7iftci","year":"2023","unstructured":"\u00c7iftci G, \u00c7iftci A, Onuk B et al (2023) Investigation of the effects of atorvastatin and Lactobacillus acidophilus on some hormones and oxidative stress in experimental hypercholesterolemia. Prostaglandins Other Lipid Mediat 165:106716. https:\/\/doi.org\/10.1016\/j.prostaglandins.2023.106716","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"1","key":"11141_CR11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41538-022-00167-x","volume":"6","author":"Y Li","year":"2022","unstructured":"Li Y, Chen M, Ma Y et al (2022) Regulation of viable\/inactivated\/lysed probiotic Lactobacillus plantarum H6 on intestinal microbiota and metabolites in hypercholesterolemic mice. NPJ Sci Food 6(1):50. https:\/\/doi.org\/10.1038\/s41538-022-00167-x","journal-title":"NPJ Sci Food"},{"key":"11141_CR12","doi-asserted-by":"publisher","first-page":"113773","DOI":"10.1016\/j.foodres.2023.113773","volume":"175","author":"L Xiao","year":"2024","unstructured":"Xiao L, Zhang C, Zhang X et al (2024) Effects of Lacticaseibacillus paracasei SNB-derived postbiotic components on intestinal barrier dysfunction and composition of gut microbiota. Food Res Int 175:113773. https:\/\/doi.org\/10.1016\/j.foodres.2023.113773","journal-title":"Food Res Int"},{"issue":"3","key":"11141_CR13","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s00253-015-7039-6","volume":"100","author":"C Liu","year":"2016","unstructured":"Liu C, Zhao D, Ma W et al (2016) Denitrifying sulfide removal process on high-salinity wastewaters in the presence of Halomonas sp. Appl Microbiol Biotechnol 100(3):1421\u20131426. https:\/\/doi.org\/10.1007\/s00253-015-7039-6","journal-title":"Appl Microbiol Biotechnol"},{"issue":"6","key":"11141_CR14","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","volume":"38","author":"GM Douglas","year":"2020","unstructured":"Douglas GM, Maffei VJ, Zaneveld JR et al (2020) PICRUSt2 for prediction of metagenome functions. Nat Biotechnol 38(6):685\u2013688. https:\/\/doi.org\/10.1038\/s41587-020-0548-6","journal-title":"Nat Biotechnol"},{"issue":"51","key":"11141_CR15","doi-asserted-by":"publisher","first-page":"E5593","DOI":"10.1073\/pnas.1419161111","volume":"111","author":"S Shen","year":"2014","unstructured":"Shen S, Park JW, Lu ZX et al (2014) rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data. Proc Natl Acad Sci U S A 111(51):E5593\u2013E5601. https:\/\/doi.org\/10.1073\/pnas.1419161111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"11141_CR16","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nbt.3122","volume":"33","author":"M Pertea","year":"2015","unstructured":"Pertea M, Pertea GM, Antonescu CM et al (2015) StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol 33(3):290\u2013295. https:\/\/doi.org\/10.1038\/nbt.3122","journal-title":"Nat Biotechnol"},{"issue":"5","key":"11141_CR17","doi-asserted-by":"publisher","first-page":"102724","DOI":"10.1016\/j.jiph.2025.102724","volume":"18","author":"L Shamkhali","year":"2025","unstructured":"Shamkhali L, Mobarez AM, Siadat SD et al (2025) Synergistic antibacterial effects of carbon dots derived from Lactobacillus acidophilus alone and in combination against carbapenem-resistant Klebsiella pneumoniae. J Infect Public Health 18(5):102724. https:\/\/doi.org\/10.1016\/j.jiph.2025.102724","journal-title":"J Infect Public Health"},{"issue":"5","key":"11141_CR18","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3390\/nu17050763","volume":"17","author":"CK Oh","year":"2025","unstructured":"Oh CK, Chung HH, Kim YJ et al (2025) Comparison of rifaximin monotherapy and rifaximin combined with probiotics in patients with irritable bowel syndrome: a randomized controlled trial. Nutrients 17(5):763. https:\/\/doi.org\/10.3390\/nu17050763","journal-title":"Nutrients"},{"key":"11141_CR19","doi-asserted-by":"publisher","first-page":"117492","DOI":"10.1016\/j.biopha.2024.117492","volume":"180","author":"T Somers","year":"2024","unstructured":"Somers T, Siddiqi S, Janssen MCM et al (2024) Effect of statins on mitochondrial function and contractile force in human skeletal and cardiac muscle. Biomed Pharmacother 180:117492. https:\/\/doi.org\/10.1016\/j.biopha.2024.117492","journal-title":"Biomed Pharmacother"},{"key":"11141_CR20","doi-asserted-by":"publisher","first-page":"106052","DOI":"10.1016\/j.tiv.2025.106052","volume":"106","author":"SXH Mthembu","year":"2025","unstructured":"Mthembu SXH, Mazibuko-Mbeje SE, Silvestri S et al (2025) Prolonged exposure to simvastatin affects coenzyme Q(9\/10) status leading to impaired mitochondrial respiratory capacity and reduced viability of cultured cardiac cells. Toxicol in Vitro 106:106052. https:\/\/doi.org\/10.1016\/j.tiv.2025.106052","journal-title":"Toxicol Vitro"},{"issue":"Pt 1","key":"11141_CR21","doi-asserted-by":"publisher","first-page":"132860","DOI":"10.1016\/j.ijbiomac.2024.132860","volume":"272","author":"J Long","year":"2024","unstructured":"Long J, Li M, Yao C et al (2024) Structural characterization of Astragalus polysaccharide-D1 and its improvement of low-dose metformin effect by enriching Staphylococcus lentus. Int J Biol Macromol 272(Pt 1):132860. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.132860","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"11141_CR22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/s2213-8587(24)00040-8","volume":"12","author":"Effects of statin therapy on diagnoses of new-onset","year":"2024","unstructured":"Effects of statin therapy on diagnoses of new-onset (2024) diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis. Lancet Diabetes Endocrinol 12(5):306\u2013319. https:\/\/doi.org\/10.1016\/s2213-8587(24)00040-8","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"11141_CR23","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4162\/nrp.2021.15.4.431","volume":"15","author":"YJ Kim","year":"2021","unstructured":"Kim YJ, Yoon DS, Jung UJ (2021) Efficacy of nobiletin in improving hypercholesterolemia and nonalcoholic fatty liver disease in high-cholesterol diet-fed mice. Nutr Res Pract 15(4):431\u2013443. https:\/\/doi.org\/10.4162\/nrp.2021.15.4.431","journal-title":"Nutr Res Pract"},{"issue":"10","key":"11141_CR24","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/j.chom.2024.09.010","volume":"32","author":"JH Hill","year":"2024","unstructured":"Hill JH, Round JL (2024) Intestinal fungal-host interactions in promoting and maintaining health. Cell Host Microbe 32(10):1668\u20131680. https:\/\/doi.org\/10.1016\/j.chom.2024.09.010","journal-title":"Cell Host Microbe"},{"issue":"8","key":"11141_CR25","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1016\/j.cell.2024.03.014","volume":"187","author":"C Li","year":"2024","unstructured":"Li C, Stra\u017ear M, Mohamed AMT et al (2024) Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria. Cell 187(8):1834\u20131852e19. https:\/\/doi.org\/10.1016\/j.cell.2024.03.014","journal-title":"Cell"},{"issue":"24","key":"11141_CR26","doi-asserted-by":"publisher","first-page":"8233","DOI":"10.1007\/s00253-022-12265-7","volume":"106","author":"T Zhai","year":"2022","unstructured":"Zhai T, Ren W, Wang P et al (2022) Lactobacillus rhamnosus GG protects against atherosclerosis by improving ketone body synthesis. Appl Microbiol Biotechnol 106(24):8233\u20138243. https:\/\/doi.org\/10.1007\/s00253-022-12265-7","journal-title":"Appl Microbiol Biotechnol"},{"key":"11141_CR27","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.ijbiomac.2022.05.130","volume":"213","author":"Y Li","year":"2022","unstructured":"Li Y, Bai D, Lu Y et al (2022) The crude guava polysaccharides ameliorate high-fat diet-induced obesity in mice via reshaping gut microbiota. Int J Biol Macromol 213:234\u2013246. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.05.130","journal-title":"Int J Biol Macromol"},{"key":"11141_CR28","doi-asserted-by":"publisher","first-page":"1127785","DOI":"10.3389\/fimmu.2023.1127785","volume":"14","author":"H Cheng","year":"2023","unstructured":"Cheng H, Zhang D, Wu J et al (2023) Atractylodes macrocephala Koidz. volatile oil relieves acute ulcerative colitis via regulating gut microbiota and gut microbiota metabolism. Front Immunol 14:1127785. https:\/\/doi.org\/10.3389\/fimmu.2023.1127785","journal-title":"Front Immunol"},{"issue":"9","key":"11141_CR29","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1124\/dmd.114.058354","volume":"42","author":"DH Yoo","year":"2014","unstructured":"Yoo DH, Kim IS, Van Le TK et al (2014) Gut microbiota-mediated drug interactions between lovastatin and antibiotics. Drug Metab Dispos 42(9):1508\u20131513. https:\/\/doi.org\/10.1124\/dmd.114.058354","journal-title":"Drug Metab Dispos"},{"key":"11141_CR30","doi-asserted-by":"publisher","unstructured":"Lucas LN, Mallikarjun J, Cattaneo LE et al (2025) Investigation of bile salt hydrolase activity in human gut bacteria reveals production of conjugated secondary bile ccids. bioRxiv 633392. https:\/\/doi.org\/10.1101\/2025.01.16.633392","DOI":"10.1101\/2025.01.16.633392"},{"key":"11141_CR31","doi-asserted-by":"publisher","first-page":"106357","DOI":"10.1016\/j.jff.2024.106357","volume":"120","author":"G Agolino","year":"2024","unstructured":"Agolino G, Pino A, Vaccalluzzo A et al (2024) bile salt hydrolase: The complexity behind its mechanism in relation to lowering-cholesterol lactobacilli probiotics. J Funct Foods 120:106357. https:\/\/doi.org\/10.1016\/j.jff.2024.106357","journal-title":"J Funct Foods"},{"issue":"10","key":"11141_CR32","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1111\/1751-7915.14293","volume":"16","author":"W Wu","year":"2023","unstructured":"Wu W, Kaicen W, Bian X et al (2023) Akkermansia muciniphila alleviates high-fat-diet-related metabolic-associated fatty liver disease by modulating gut microbiota and bile acids. Microb Biotechnol 16(10):1924\u20131939. https:\/\/doi.org\/10.1111\/1751-7915.14293","journal-title":"Microb Biotechnol"},{"issue":"2","key":"11141_CR33","doi-asserted-by":"publisher","first-page":"CD014857","DOI":"10.1002\/14651858.CD014857","volume":"24","author":"SP Adams","year":"2023","unstructured":"Adams SP, Alaeiilkhchi N, Wright JM (2023) Simvastatin for lowering lipids. Cochrane Database Syst Rev 24(2):CD014857. https:\/\/doi.org\/10.1002\/14651858.CD014857","journal-title":"Cochrane Database Syst Rev"},{"issue":"29","key":"11141_CR34","doi-asserted-by":"publisher","first-page":"eabg3188","DOI":"10.1126\/sciadv.abg3188","volume":"7","author":"M Hu","year":"2021","unstructured":"Hu M, Yang F, Huang Y et al (2021) Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake. Sci Adv 7(29):eabg3188. https:\/\/doi.org\/10.1126\/sciadv.abg3188","journal-title":"Sci Adv"},{"issue":"2","key":"11141_CR35","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1134\/S0026893323020188","volume":"57","author":"DV Sherbakov","year":"2023","unstructured":"Sherbakov DV, Arefieva AB, Komleva PD et al (2023) Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration. Mol Biol (Mosk) 57(2):299\u2013306","journal-title":"Mol Biol (Mosk)"},{"issue":"23","key":"11141_CR36","doi-asserted-by":"publisher","first-page":"12808","DOI":"10.3390\/ijms222312808","volume":"22","author":"M Zhao","year":"2021","unstructured":"Zhao M, Ma J, Li M et al (2021) Cytochrome P450 enzymes and drug metabolism in humans. Int J Mol Sci 22(23):12808. https:\/\/doi.org\/10.3390\/ijms222312808","journal-title":"Int J Mol Sci"},{"key":"11141_CR37","doi-asserted-by":"publisher","first-page":"4680732","DOI":"10.1155\/2017\/4680732","volume":"2017","author":"WA Garc\u00eda-Su\u00e1stegui","year":"2017","unstructured":"Garc\u00eda-Su\u00e1stegui WA, Ramos-Ch\u00e1vez LA, Rubio-Osornio M et al (2017) The role of CYP2E1 in the drug metabolism or bioactivation in the brain. Oxid Med Cell Longev 2017:4680732. https:\/\/doi.org\/10.1155\/2017\/4680732","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"11141_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1039\/c7tx00020k","volume":"6","author":"JH Hartman","year":"2017","unstructured":"Hartman JH, Miller GP, Meyer JN (2017) Toxicological implications of mitochondrial localization of CYP2E1. Toxicol Res 6(3):273\u2013289. https:\/\/doi.org\/10.1039\/c7tx00020k","journal-title":"Toxicol Res"},{"issue":"15","key":"11141_CR39","doi-asserted-by":"publisher","first-page":"4811","DOI":"10.7150\/ijbs.87975","volume":"19","author":"Y Liu","year":"2023","unstructured":"Liu Y, Liu T, Zhang F et al (2023) Unraveling the complex interplay between epigenetics and immunity in alcohol-associated liver disease: A comprehensive review. Int J Biol Sci 19(15):4811\u20134830. https:\/\/doi.org\/10.7150\/ijbs.87975","journal-title":"Int J Biol Sci"},{"issue":"6","key":"11141_CR40","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3390\/jpm11060554","volume":"11","author":"Y Jarrar","year":"2021","unstructured":"Jarrar Y, Lee S-J (2021) The functionality of UDP-glucuronosyltransferase genetic variants and their association with drug responses and human diseases. J Personalized Med 11(6):554","journal-title":"J Personalized Med"},{"issue":"6","key":"11141_CR41","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","volume":"23","author":"A Agus","year":"2018","unstructured":"Agus A, Planchais J, Sokol H (2018) Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23(6):716\u2013724. https:\/\/doi.org\/10.1016\/j.chom.2018.05.003","journal-title":"Cell Host Microbe"},{"issue":"1","key":"11141_CR42","doi-asserted-by":"publisher","first-page":"191","DOI":"10.26599\/FSHW.2022.9250016","volume":"13","author":"X Li","year":"2024","unstructured":"Li X, Ma W, Yang T et al (2024) Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: A community-based case-control study in the Chinese elderly. Food Sci Hum Wellness 13(1):191\u2013197. https:\/\/doi.org\/10.26599\/FSHW.2022.9250016","journal-title":"Food Sci Hum Wellness"},{"issue":"10","key":"11141_CR43","doi-asserted-by":"publisher","first-page":"6423","DOI":"10.1021\/cr200021m","volume":"111","author":"WD Nes","year":"2011","unstructured":"Nes WD (2011) Biosynthesis of cholesterol and other sterols. Chem Rev 111(10):6423\u20136451. https:\/\/doi.org\/10.1021\/cr200021m","journal-title":"Chem Rev"},{"key":"11141_CR44","doi-asserted-by":"publisher","first-page":"115586","DOI":"10.1016\/j.biopha.2023.115586","volume":"170","author":"Q Sun","year":"2024","unstructured":"Sun Q, Xing X, Wang H et al (2024) SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors. Biomed Pharmacother 170:115586. https:\/\/doi.org\/10.1016\/j.biopha.2023.115586","journal-title":"Biomed Pharmacother"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11141-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-026-11141-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11141-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:30:47Z","timestamp":1784187047000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-026-11141-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":44,"alternative-id":["11141"],"URL":"https:\/\/doi.org\/10.1007\/s12602-026-11141-4","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"13 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}