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Prot."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Crohn\u2019s disease (CD) is a chronic gastrointestinal disorder involving host genetics, environment, and gut microbiota, with microbial-based approaches holding high therapeutic potential. This study focused on the potential of\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    to attenuate intestinal inflammation in SAMP1\/YitFc mouse models of colitis and ileitis. We tested the potential of\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    to; (i) protect against the severity of dextran sodium sulfate (DSS)-induced colitis (acute flare model), (ii) prolong Dexamethasone (DEX)-induced remission in older SAMP mice with established ileitis (remission model), (iii) prevent\/attenuate disease onset in young SAMP mice (preclinical model). Body weight, fecal myeloperoxidase (fMPO), gut permeability (fluorescein isothiocyanate (FITC)-dextran), colonoscopy, 3-D stereomicroscopy and histology of intestinal tissues were assessed. Administration of\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    (Lac) significantly attenuated intestinal inflammation across multiple SAMP mouse models. In DSS-induced colitis, treatment improved clinical and histologic disease activity, evidenced by greater weight retention, preserved colon length, enhanced barrier integrity, and reduced fMPO and colonoscopy scores (Lac: 3.1\u2009\u00b1\u20090.8 vs. control: 5.3\u2009\u00b1\u20091.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). In DEX-induced remission model,\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    prolonged remission and reduced relapse severity, demonstrated by improved weight maintenance, decreased gut permeability and inflammatory burden, and lower histologic scores (Lac: 6.0\u2009\u00b1\u20092.1 vs. control; 9.6\u2009\u00b1\u20092.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). Early-life intervention further mitigated spontaneous ileitis, with reductions in intestinal permeability, inflammatory activity, and macroscopic lesion severity (Lac: 0.6\u2009\u00b1\u20090.7 vs. control: 1.9\u2009\u00b1\u20090.6,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03).\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    improved gut barrier integrity and attenuated intestinal inflammation in experimental colitis and chronic ileitis models of IBD.\n                  <\/jats:p>","DOI":"10.1007\/s12602-026-11166-9","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:00:44Z","timestamp":1786514444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactobacillus plantarum Attenuates Intestinal Inflammation and Prolongs Remission in Experimental Models of Crohn\u2019s Disease"],"prefix":"10.1007","author":[{"given":"Drishtant","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Achanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Menghini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Delffs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rodriguez-Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Di Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cominelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail Raffner","family":"Basson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"Suppl 1","key":"11166_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/jgh.12751","volume":"30","author":"C Fiocchi","year":"2015","unstructured":"Fiocchi C (2015) Inflammatory bowel disease pathogenesis: where are we? 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Additional support of this work was provided by R56DK055812, P01DK091222 and P30DK097948 (to FC), Germ-free and Gut Microbiome Core P01DK091222 and R21DK118373 (to ARP). We want to acknowledge the support of the Mouse Models, the Histology Imaging, and Tissue Biorepository Cores of the NIH P30 Silvio O. Conte Cleveland Digestive Diseases Research Core Center.","order":2,"name":"Ethics","label":"Financial Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}}]}}