{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:53:34Z","timestamp":1791266014605,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["No. Zong20240008"],"award-info":[{"award-number":["No. Zong20240008"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds for the Central Universities - Directed Exploration Projec","award":["No. lzujbky-2025-26"],"award-info":[{"award-number":["No. lzujbky-2025-26"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"DOI":"10.1007\/s12602-026-11187-4","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:15:20Z","timestamp":1791263720000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediococcus acidilactici ZQ-19 Ameliorates Ulcerative Colitis via Remodeling Gut Microbiota and Glutathione Redox Homeostasis"],"prefix":"10.1007","author":[{"given":"Yimeng","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunhui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1062-2298","authenticated-orcid":false,"given":"Zitong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"11187_CR1","doi-asserted-by":"publisher","first-page":"6237","DOI":"10.3390\/jcm14176237","volume":"14","author":"I Silva","year":"2025","unstructured":"Silva I, da Silva MTB (2025) Inflammatory Bowel Disease (IBD): Clinical Diagnosis and Treatment. J Clin Med 14:6237. https:\/\/doi.org\/10.3390\/jcm14176237","journal-title":"J Clin Med"},{"key":"11187_CR2","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N et al (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390:2769\u20132778. https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0","journal-title":"Lancet"},{"key":"11187_CR3","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3390\/medicina58050567","volume":"58","author":"AE M\u2019Koma","year":"2022","unstructured":"M\u2019Koma AE (2022) Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview. Med (Kaunas) 58:567. https:\/\/doi.org\/10.3390\/medicina58050567","journal-title":"Med (Kaunas)"},{"key":"11187_CR4","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1080\/00365521.2021.1998601","volume":"57","author":"Y Tsujii","year":"2022","unstructured":"Tsujii Y, Nishida T, Osugi N et al (2022) Classification and clinical features of adverse drug reactions in patients with ulcerative colitis treated with 5-aminosalicylate acid: a single-center, observational study. Scand J Gastroenterol 57:190\u2013196. https:\/\/doi.org\/10.1080\/00365521.2021.1998601","journal-title":"Scand J Gastroenterol"},{"key":"11187_CR5","doi-asserted-by":"publisher","unstructured":"Ying Y, Shen M, Chen J et al (2026) Drug-associated inflammatory bowel disease: a real-world pharmacovigilance study using the FAERS and JADER databases. Front Immunol 17. https:\/\/doi.org\/10.3389\/fimmu.2026.1873829","DOI":"10.3389\/fimmu.2026.1873829"},{"key":"11187_CR6","doi-asserted-by":"publisher","first-page":"e202400568","DOI":"10.1002\/mnfr.202400568","volume":"69","author":"H Li","year":"2025","unstructured":"Li H, Fan L, Yang S et al (2025) Lactobacillus acidophilus 6074 Fermented Jujube Juice Ameliorated DSS-induced Colitis via Repairing Intestinal Barrier, Modulating Inflammatory Factors, and Gut Microbiota. Mol Nutr Food Res 69:e202400568. https:\/\/doi.org\/10.1002\/mnfr.202400568","journal-title":"Mol Nutr Food Res"},{"key":"11187_CR7","doi-asserted-by":"publisher","first-page":"102593","DOI":"10.1016\/j.redox.2022.102593","volume":"59","author":"M Schwarz","year":"2023","unstructured":"Schwarz M, L\u00f6ser A, Cheng Q et al (2023) Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides. Redox Biol 59:102593. https:\/\/doi.org\/10.1016\/j.redox.2022.102593","journal-title":"Redox Biol"},{"key":"11187_CR8","doi-asserted-by":"publisher","first-page":"955112","DOI":"10.3389\/fmicb.2022.955112","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu Y, Jin X, Gao F et al (2022) Selenium-enriched Bifidobacterium longum DD98 effectively ameliorates dextran sulfate sodium-induced ulcerative colitis in mice. Front Microbiol 13:955112. https:\/\/doi.org\/10.3389\/fmicb.2022.955112","journal-title":"Front Microbiol"},{"key":"11187_CR9","doi-asserted-by":"publisher","first-page":"103664","DOI":"10.1016\/j.redox.2025.103664","volume":"83","author":"A Ichikawa","year":"2025","unstructured":"Ichikawa A, Toyama T, Taguchi H et al (2025) The selenoprotein P\/ApoER2 axis facilitates selenium accumulation in selenoprotein P-accepting cells and confers prolonged resistance to ferroptosis. Redox Biol 83:103664. https:\/\/doi.org\/10.1016\/j.redox.2025.103664","journal-title":"Redox Biol"},{"key":"11187_CR10","doi-asserted-by":"publisher","unstructured":"Acampora L, Restolfer F, De Pierro P et al (2026) The gut-thyroid axis: physiological regulation of barrier function, microbiota, endocrine signaling and the consequences on energy metabolism. Front Physiol 17. https:\/\/doi.org\/10.3389\/fphys.2026.1753136","DOI":"10.3389\/fphys.2026.1753136"},{"key":"11187_CR11","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1007\/s12011-021-02832-w","volume":"200","author":"J Cao","year":"2022","unstructured":"Cao J, Liu X, Cheng Y et al (2022) Selenium-enriched Polysaccharide: an Effective and Safe Selenium Source of C57 Mice to Improve Growth Performance, Regulate Selenium Deposition, and Promote Antioxidant Capacity. Biol Trace Elem Res 200:2247\u20132258. https:\/\/doi.org\/10.1007\/s12011-021-02832-w","journal-title":"Biol Trace Elem Res"},{"key":"11187_CR12","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.jff.2017.06.008","volume":"35","author":"W Ding","year":"2017","unstructured":"Ding W, Wang L, Zhang J et al (2017) Characterization of antioxidant properties of lactic acid bacteria isolated from spontaneously fermented yak milk in the Tibetan Plateau. J Funct Foods 35:481\u2013488. https:\/\/doi.org\/10.1016\/j.jff.2017.06.008","journal-title":"J Funct Foods"},{"key":"11187_CR13","doi-asserted-by":"publisher","first-page":"113027","DOI":"10.1016\/j.lwt.2021.113027","volume":"156","author":"Z Ding","year":"2022","unstructured":"Ding Z, Mi J, Zhou J et al (2022) Characterization of the microbial community compositions and diversities in the traditional fermented yak milk from different ecotopes on the Qinghai-Tibetan plateau. LWT 156:113027. https:\/\/doi.org\/10.1016\/j.lwt.2021.113027","journal-title":"LWT"},{"key":"11187_CR14","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12934-019-1161-6","volume":"18","author":"A Li","year":"2019","unstructured":"Li A, Wang Y, Li Z et al (2019) Probiotics isolated from yaks improves the growth performance, antioxidant activity, and cytokines related to immunity and inflammation in mice. Microb Cell Fact 18:112. https:\/\/doi.org\/10.1186\/s12934-019-1161-6","journal-title":"Microb Cell Fact"},{"key":"11187_CR15","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1039\/d3fo05337g","volume":"15","author":"W Li","year":"2024","unstructured":"Li W, Zhang Y, Chen M et al (2024) The antioxidant strain Lactiplantibacillus plantarum AS21 and Clostridium butyricum ameliorate DSS-induced colitis in mice by remodeling the assembly of intestinal microbiota and improving gut functions. Food Funct 15:2022\u20132037. https:\/\/doi.org\/10.1039\/d3fo05337g","journal-title":"Food Funct"},{"key":"11187_CR16","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.4315\/0362-028X.JFP-16-096","volume":"79","author":"S Xu","year":"2016","unstructured":"Xu S, Liu T, Radji CAI et al (2016) Isolation, Identification, and Evaluation of New Lactic Acid Bacteria Strains with Both Cellular Antioxidant and Bile Salt Hydrolase Activities In Vitro. J Food Prot 79:1919\u20131928. https:\/\/doi.org\/10.4315\/0362-028X.JFP-16-096","journal-title":"J Food Prot"},{"key":"11187_CR17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.fm.2012.10.005","volume":"33","author":"AA Argyri","year":"2013","unstructured":"Argyri AA, Zoumpopoulou G, Karatzas K-AG et al (2013) Selection of potential probiotic lactic acid bacteria from fermented olives by in vitro tests. Food Microbiol 33:282\u2013291. https:\/\/doi.org\/10.1016\/j.fm.2012.10.005","journal-title":"Food Microbiol"},{"key":"11187_CR18","doi-asserted-by":"publisher","first-page":"4165","DOI":"10.1002\/jsfa.13298","volume":"104","author":"MA G\u00fcler","year":"2024","unstructured":"G\u00fcler MA, \u00c7etin B, Albayrak B et al (2024) Isolation, identification, and in vitro probiotic characterization of forty novel Bifidobacterium strains from neonatal feces in Erzurum province, T\u00fcrkiye. J Sci Food Agric 104:4165\u20134175. https:\/\/doi.org\/10.1002\/jsfa.13298","journal-title":"J Sci Food Agric"},{"key":"11187_CR19","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1007\/s00210-024-03485-x","volume":"398","author":"J Wang","year":"2025","unstructured":"Wang J, Wang X, Jiang M et al (2025) 5-aminosalicylic acid alleviates colitis and protects intestinal barrier function by modulating gut microbiota in mice. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 398:3681\u20133695. https:\/\/doi.org\/10.1007\/s00210-024-03485-x","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"11187_CR20","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1365-2621.2000.tb09412.x","volume":"65","author":"D Jaroni","year":"2000","unstructured":"Jaroni D, Brashears Mm (2000) Production of Hydrogen Peroxide by Lactobacillus delbrueckii subsp. lactis as Influenced by Media Used for Propagation of Cells. J Food Sci 65:1033\u20131036. https:\/\/doi.org\/10.1111\/j.1365-2621.2000.tb09412.x","journal-title":"J Food Sci"},{"key":"11187_CR21","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3390\/foods10061203","volume":"10","author":"H Zhang","year":"2021","unstructured":"Zhang H, Xu J, Chen Q et al (2021) Physiological, Morphological and Antioxidant Responses of Pediococcus pentosaceus R1 and Lactobacillus fermentum R6 Isolated from Harbin Dry Sausages to Oxidative Stress. Foods 10:1203. https:\/\/doi.org\/10.3390\/foods10061203","journal-title":"Foods"},{"key":"11187_CR22","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.3390\/foods14111863","volume":"14","author":"R Zang","year":"2025","unstructured":"Zang R, Zhou R, Li Y et al (2025) Oleuropein Regulates Bile Acid Metabolism via Modulating the Gut Microbiota, Thereby Alleviating DSS-Induced Ulcerative Colitis in Mice. Foods 14:1863. https:\/\/doi.org\/10.3390\/foods14111863","journal-title":"Foods"},{"key":"11187_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s40168-022-01306-y","volume":"10","author":"I Huber-Ruano","year":"2022","unstructured":"Huber-Ruano I, Calvo E, Mayneris-Perxachs J et al (2022) Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate. Microbiome 10:135. https:\/\/doi.org\/10.1186\/s40168-022-01306-y","journal-title":"Microbiome"},{"key":"11187_CR24","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1053\/j.gastro.2021.09.061","volume":"162","author":"SF Lima","year":"2022","unstructured":"Lima SF, Gogokhia L, Viladomiu M et al (2022) Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. Gastroenterology 162:166\u2013178. https:\/\/doi.org\/10.1053\/j.gastro.2021.09.061","journal-title":"Gastroenterology"},{"key":"11187_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3390\/fermentation10040207","volume":"10","author":"J Yang","year":"2024","unstructured":"Yang J, Fan Y, Jin R et al (2024) Exploring the Intestinal Microbial Community of Lantang Pigs through Metagenome-Assembled Genomes and Carbohydrate Degradation Genes. Fermentation 10:207. https:\/\/doi.org\/10.3390\/fermentation10040207","journal-title":"Fermentation"},{"key":"11187_CR26","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1038\/s41564-019-0540-4","volume":"4","author":"TC Fung","year":"2019","unstructured":"Fung TC, Vuong HE, Luna CDG et al (2019) Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut. Nat Microbiol 4:2064\u20132073. https:\/\/doi.org\/10.1038\/s41564-019-0540-4","journal-title":"Nat Microbiol"},{"key":"11187_CR27","doi-asserted-by":"publisher","first-page":"fiaf077","DOI":"10.1093\/femsec\/fiaf077","volume":"101","author":"SH Duncan","year":"2025","unstructured":"Duncan SH, Sabater C (2025) Emerging probiotics: future therapeutics for human gut health. FEMS Microbiol Ecol 101:fiaf077. https:\/\/doi.org\/10.1093\/femsec\/fiaf077","journal-title":"FEMS Microbiol Ecol"},{"key":"11187_CR28","doi-asserted-by":"publisher","unstructured":"Akanda KMMD, Mehjabin S, Hasan AHMN, Parvez GMM (2025) Role of reactive oxygen species, superoxide dismutases, and inflammation in association with gut microbiota and inflammatory bowel disease. In: Mishra N (ed) Inflammatory bowel diseaseand gut microbiota: Current Strategies and Future Prospects in Nanomedicine. Apple Academic Press, pp 349\u2013374. https:\/\/doi.org\/10.1201\/9781003598336-11","DOI":"10.1201\/9781003598336-11"},{"key":"11187_CR29","doi-asserted-by":"publisher","first-page":"578386","DOI":"10.3389\/fimmu.2021.578386","volume":"12","author":"F Cristofori","year":"2021","unstructured":"Cristofori F, Dargenio VN, Dargenio C et al (2021) Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body. Front Immunol 12:578386. https:\/\/doi.org\/10.3389\/fimmu.2021.578386","journal-title":"Front Immunol"},{"key":"11187_CR30","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/antiox7030036","volume":"7","author":"SK Nettleford","year":"2018","unstructured":"Nettleford SK, Prabhu KS (2018) Selenium and Selenoproteins in Gut Inflammation-A Review. Antioxid (Basel) 7:36. https:\/\/doi.org\/10.3390\/antiox7030036","journal-title":"Antioxid (Basel)"},{"key":"11187_CR31","doi-asserted-by":"publisher","first-page":"4535194","DOI":"10.1155\/2017\/4535194","volume":"2017","author":"T Tian","year":"2017","unstructured":"Tian T, Wang Z, Zhang J (2017) Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxid Med Cell Longev 2017:4535194. https:\/\/doi.org\/10.1155\/2017\/4535194","journal-title":"Oxid Med Cell Longev"},{"key":"11187_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12967-022-03235-8","volume":"20","author":"F Dong","year":"2022","unstructured":"Dong F, Xiao F, Li X et al (2022) Pediococcus pentosaceus CECT 8330 protects DSS-induced colitis and regulates the intestinal microbiota and immune responses in mice. J Transl Med 20:33. https:\/\/doi.org\/10.1186\/s12967-022-03235-8","journal-title":"J Transl Med"},{"key":"11187_CR33","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.celrep.2015.07.042","volume":"12","author":"RM Jones","year":"2015","unstructured":"Jones RM, Desai C, Darby TM et al (2015) Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Cell Rep 12:1217\u20131225. https:\/\/doi.org\/10.1016\/j.celrep.2015.07.042","journal-title":"Cell Rep"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11187-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-026-11187-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11187-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:15:21Z","timestamp":1791263721000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-026-11187-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":33,"alternative-id":["11187"],"URL":"https:\/\/doi.org\/10.1007\/s12602-026-11187-4","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"5 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the Animal Welfare and Ethics Committee of Lanzhou University (Approval No. EAF2023023) and complied with the NIH Guide for the Care and Use of Laboratory Animals.","order":1,"name":"Ethics","label":"Ethical statements","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}