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Prot."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Probiotic-based strategies have gained increasing attention as potential interventions for obesity and metabolic disorders.\n                    <jats:italic>Lactococcus lactis<\/jats:italic>\n                    subsp.\n                    <jats:italic>lactis<\/jats:italic>\n                    CAB701 (CAB701), a cabbage-derived probiotic strain, has demonstrated anti-adipogenic activity in preclinical studies; however, its clinical efficacy has not been established. We conducted a single-centre, randomized, double-blind, placebo-controlled 12-week trial in 100 Korean adults with overweight or obesity (mean age 48.9\u2009\u00b1\u200913.9 years; body mass index (BMI) 25.8\u2009\u00b1\u20091.8\u00a0kg\/m\u00b2; 19% men). Participants were randomized 1:1 to receive 150\u00a0mg\/day CAB701 or placebo. The primary endpoint was change in total body fat mass measured by dual-energy X-ray absorptiometry (DXA). In the intention-to-treat analysis, the adjusted between-group difference in change in body fat mass was \u2212\u20091.59\u00a0kg (95% CI\u2009\u2212\u20092.50 to \u2212\u20090.67;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with consistent findings in the per-protocol (PP) analysis (\u2212\u20091.54\u00a0kg; 95% CI\u2009\u2212\u20092.25 to \u2212\u20090.83;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Significant reductions were also observed in body weight and BMI; body fat percentage was significant in the PP analysis only. Waist circumference, lipid parameters, adiponectin, and inflammatory markers did not differ between groups. No treatment-related serious adverse events were reported. In conclusion, CAB701 supplementation for 12 weeks significantly reduced DXA-measured body fat mass and was well tolerated. These findings support the potential of CAB701 as a strain-specific functional probiotic for the reduction of adiposity in humans. This trial was registered in clinicaltrials.gov with registration number NCT06628791.\n                  <\/jats:p>","DOI":"10.1007\/s12602-026-11198-1","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:44:41Z","timestamp":1788335081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactococcus Lactis Subsp. 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