{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:48:57Z","timestamp":1791676137574,"version":"4.3.4"},"reference-count":157,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Yuelushan Laboratory joint talent introduction project","award":["2024RC2053"],"award-info":[{"award-number":["2024RC2053"]}]},{"name":"Natural Science Foundation of Changsha, China","award":["Grant No. kq2502176"],"award-info":[{"award-number":["Grant No. kq2502176"]}]},{"name":"Scientific Research Project of Hunan Provincial Department of Education","award":["24B0219"],"award-info":[{"award-number":["24B0219"]}]},{"name":"Hunan Province Postgraduate Education Teaching Reform Research Project","award":["2025JGZD053"],"award-info":[{"award-number":["2025JGZD053"]}]},{"name":"National Key Research and Development Program of China","award":["2023YFD1301200"],"award-info":[{"award-number":["2023YFD1301200"]}]},{"name":"Hunan Poultry Industry Technology System","award":["HARS-06"],"award-info":[{"award-number":["HARS-06"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"DOI":"10.1007\/s12602-026-11246-w","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:32:48Z","timestamp":1791667968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Gut-Brain Axis and Neurodegenerative Diseases: From Mechanistic Pathways to Therapeutic Interventions"],"prefix":"10.1007","author":[{"given":"Weilun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"issue":"6","key":"11246_CR1","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","volume":"23","author":"A Agus","year":"2018","unstructured":"Agus A, Planchais J, Sokol H (2018) Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23(6):716\u2013724. https:\/\/doi.org\/10.1016\/j.chom.2018.05.003","journal-title":"Cell Host Microbe"},{"issue":"2","key":"11246_CR2","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1007\/s10787-023-01427-2","volume":"32","author":"C Akhgarjand","year":"2024","unstructured":"Akhgarjand C, Vahabi Z, Shab-Bidar S, Anoushirvani A, Djafarian K (2024) The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer\u2019s disease: A randomized, double-blind, placebo-controlled study. Inflammopharmacology 32(2):1413\u20131420. https:\/\/doi.org\/10.1007\/s10787-023-01427-2","journal-title":"Inflammopharmacology"},{"key":"11246_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.neurobiolaging.2025.01.003","volume":"147","author":"HSS Al Shamsi","year":"2025","unstructured":"Al Shamsi HSS, Gardener SL, Rainey-Smith SR, Pedrini S, Sohrabi HR, Taddei K, Masters CL, Martins RN, Fernando WMADB, AIBL research group (2025) The moderating effect of diet on the relationship between depressive symptoms and Alzheimer\u2019s disease-related blood-based biomarkers. Neurobiol Aging 147:213\u2013222. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.01.003","journal-title":"Neurobiol Aging"},{"issue":"1","key":"11246_CR4","doi-asserted-by":"publisher","first-page":"23095","DOI":"10.1038\/s41598-024-74400-w","volume":"14","author":"V Andreozzi","year":"2024","unstructured":"Andreozzi V, Cuoco S, Balestrieri M, Fierro F, Ferrara N, Erro R, Di Filippo M, Barbella G, Memoli MC, Silvestri A, Squillante M, Guglielmetti S, Barone P, Iovino P, Pellecchia MT (2024) Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson\u2019s disease: Results from an open label single-arm study. Sci Rep 14(1):23095. https:\/\/doi.org\/10.1038\/s41598-024-74400-w","journal-title":"Sci Rep"},{"issue":"4","key":"11246_CR5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/YCO.0000000000000605","volume":"33","author":"C Angeloni","year":"2020","unstructured":"Angeloni C, Businaro R, Vauzour D (2020) The role of diet in preventing and reducing cognitive decline. Curr Opin Psychiatry 33(4):432\u2013438. https:\/\/doi.org\/10.1097\/YCO.0000000000000605","journal-title":"Curr Opin Psychiatry"},{"issue":"1","key":"11246_CR6","doi-asserted-by":"publisher","first-page":"18577","DOI":"10.1038\/s41598-023-46047-6","volume":"13","author":"KM Asghari","year":"2023","unstructured":"Asghari KM, Dolatkhah N, Ayromlou H, Mirnasiri F, Dadfar T, Hashemian M (2023) The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: A randomized clinical trial. Sci Rep 13(1):18577. https:\/\/doi.org\/10.1038\/s41598-023-46047-6","journal-title":"Sci Rep"},{"issue":"6","key":"11246_CR7","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.chom.2015.05.012","volume":"17","author":"F B\u00e4ckhed","year":"2015","unstructured":"B\u00e4ckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, Li Y, Xia Y, Xie H, Zhong H, Khan MT, Zhang J, Li J, Xiao L, Al-Aama J, Zhang D, Lee YS, Kotowska D, Colding C, Wang J (2015) Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17(6):852. https:\/\/doi.org\/10.1016\/j.chom.2015.05.012","journal-title":"Cell Host Microbe"},{"issue":"20","key":"11246_CR8","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.3390\/nu17203313","volume":"17","author":"H-I Baek","year":"2025","unstructured":"Baek H-I, Kwon S-Y, Noh H-J, Son SY, Joo JC, Park SJ (2025) Efficacy and safety of lactobacillus delbrueckii subsp. lactis CKDB001 supplementation on cognitive function in mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial. Nutrients 17(20):3313. https:\/\/doi.org\/10.3390\/nu17203313","journal-title":"Nutrients"},{"key":"11246_CR9","doi-asserted-by":"publisher","first-page":"102236","DOI":"10.1016\/j.arr.2024.102236","volume":"95","author":"B Bashir","year":"2024","unstructured":"Bashir B, Alam S, Khandale N, Birla D, Vishwas S, Pandey NK, Gupta G, Paudel KR, Dureja H, Kumar P, Singh TG, Kuppusamy G, Zacconi FC, Pinto T, de Dhanasekaran JA, Gulati M, Dua M, K., Singh SK (2024) Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation. Ageing Res Rev 95:102236. https:\/\/doi.org\/10.1016\/j.arr.2024.102236","journal-title":"Ageing Res Rev"},{"issue":"1","key":"11246_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41531-025-00885-5","volume":"11","author":"JR Bedarf","year":"2025","unstructured":"Bedarf JR, Romano S, Heinzmann SS, Duncan A, Traka MH, Ng D, Segovia-Lizano D, Simon M-C, Narbad A, W\u00fcllner U, Hildebrand F (2025) A prebiotic dietary pilot intervention restores faecal metabolites and may be neuroprotective in Parkinson\u2019s Disease. NPJ Parkinson\u2019s Disease 11(1):66. https:\/\/doi.org\/10.1038\/s41531-025-00885-5","journal-title":"NPJ Parkinson\u2019s Disease"},{"issue":"2","key":"11246_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.chom.2021.01.009","volume":"29","author":"N Benech","year":"2021","unstructured":"Benech N, Rolhion N, Sokol H (2021) Tryptophan metabolites get the gut moving. Cell Host Microbe 29(2):145\u2013147. https:\/\/doi.org\/10.1016\/j.chom.2021.01.009","journal-title":"Cell Host Microbe"},{"issue":"10291","key":"11246_CR12","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet (London England) 397(10291):2284\u20132303. https:\/\/doi.org\/10.1016\/S0140-6736(21)00218-X","journal-title":"Lancet (London England)"},{"issue":"13","key":"11246_CR13","doi-asserted-by":"publisher","first-page":"11312","DOI":"10.1074\/jbc.M211609200","volume":"278","author":"AJ Brown","year":"2003","unstructured":"Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Dowell SJ (2003) The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278(13):11312\u201311319. https:\/\/doi.org\/10.1074\/jbc.M211609200","journal-title":"J Biol Chem"},{"key":"11246_CR14","doi-asserted-by":"publisher","first-page":"102563","DOI":"10.1016\/j.eclinm.2024.102563","volume":"71","author":"A Bruggeman","year":"2024","unstructured":"Bruggeman A, Vandendriessche C, Hamerlinck H, De Looze D, Tate DJ, Vuylsteke M, De Commer L, Devolder L, Raes J, Verhasselt B, Laukens D, Vandenbroucke RE, Santens P (2024) Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson\u2019s disease (GUT-PARFECT): A double-blind, placebo-controlled, randomised, phase 2 trial. EClinicalMedicine 71:102563. https:\/\/doi.org\/10.1016\/j.eclinm.2024.102563","journal-title":"EClinicalMedicine"},{"issue":"7","key":"11246_CR15","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.biopsych.2016.12.031","volume":"82","author":"A Burokas","year":"2017","unstructured":"Burokas A, Arboleya S, Moloney RD, Peterson VL, Murphy K, Clarke G, Stanton C, Dinan TG, Cryan JF (2017) Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biol Psychiatry 82(7):472\u2013487. https:\/\/doi.org\/10.1016\/j.biopsych.2016.12.031","journal-title":"Biol Psychiatry"},{"issue":"10","key":"11246_CR16","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1002\/mds.28675","volume":"36","author":"M Camacho","year":"2021","unstructured":"Camacho M, Greenland JC, Williams-Gray CH (2021) The gastrointestinal dysfunction scale for Parkinson\u2019s disease. Mov Disorders: Official J Mov Disorder Soc 36(10):2358\u20132366. https:\/\/doi.org\/10.1002\/mds.28675","journal-title":"Mov Disorders: Official J Mov Disorder Soc"},{"issue":"1","key":"11246_CR17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12974-025-03454-y","volume":"22","author":"Q Cao","year":"2025","unstructured":"Cao Q, Shen M, Li R, Liu Y, Zeng Z, Zhou J, Niu D, Zhang Q, Wang R, Yao J, Zhang G (2025) Elucidating the specific mechanisms of the gut-brain axis: The short-chain fatty acids-microglia pathway. J Neuroinflamm 22(1):133. https:\/\/doi.org\/10.1186\/s12974-025-03454-y","journal-title":"J Neuroinflamm"},{"issue":"8","key":"11246_CR18","doi-asserted-by":"publisher","first-page":"102256","DOI":"10.1016\/j.xcrm.2025.102256","volume":"6","author":"MM Carter","year":"2025","unstructured":"Carter MM, Demis D, Perelman D, St Onge M, Petlura C, Cunanan K, Mathi K, Maecker HT, Chow JM, Robinson JL, Sabag-Daigle A, Sonnenburg ED, Buck RH, Gardner CD, Sonnenburg JL (2025) A human milk oligosaccharide alters the microbiome, circulating hormones, and metabolites in a randomized controlled trial of older adults. Cell Rep Med 6(8):102256. https:\/\/doi.org\/10.1016\/j.xcrm.2025.102256","journal-title":"Cell Rep Med"},{"issue":"40","key":"11246_CR19","doi-asserted-by":"publisher","first-page":"10713","DOI":"10.1073\/pnas.1711235114","volume":"114","author":"E Cekanaviciute","year":"2017","unstructured":"Cekanaviciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, Kanner R, Bencosme Y, Lee YK, Hauser SL, Crabtree-Hartman E, Sand IK, Gacias M, Zhu Y, Casaccia P, Cree BAC, Knight R, Mazmanian SK, Baranzini SE (2017) Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc Natl Acad Sci 114(40):10713\u201310718. https:\/\/doi.org\/10.1073\/pnas.1711235114","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"11246_CR20","doi-asserted-by":"publisher","first-page":"eadr8055","DOI":"10.1126\/sciadv.adr8055","volume":"11","author":"X Chang","year":"2025","unstructured":"Chang X, Tse AM, Fayzullina M, Albanese A, Kim M, Wang CF, Zheng Z, Joshi RV, Williams CK, Magaki SD, Vinters HV, Jones JO, Haworth IS, Seidler PM (2025) Monoaminergic neurotransmitters are bimodal effectors of tau aggregation. Sci Adv 11(5):eadr8055. https:\/\/doi.org\/10.1126\/sciadv.adr8055","journal-title":"Sci Adv"},{"issue":"11","key":"11246_CR21","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1136\/gutjnl-2021-326269","volume":"71","author":"C Chen","year":"2022","unstructured":"Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K (2022) Gut microbiota regulate Alzheimer\u2019s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut 71(11):2233\u20132252. https:\/\/doi.org\/10.1136\/gutjnl-2021-326269","journal-title":"Gut"},{"issue":"4","key":"11246_CR22","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.3233\/JPD-223179","volume":"12","author":"S-J Chen","year":"2022","unstructured":"Chen S-J, Chen C-C, Liao H-Y, Wu Y-W, Liou J-M, Wu M-S, Kuo C-H, Lin C-H (2022) Alteration of gut microbial metabolites in the systemic circulation of patients with Parkinson\u2019s disease. J Parkinson\u2019s Disease 12(4):1219\u20131230. https:\/\/doi.org\/10.3233\/JPD-223179","journal-title":"J Parkinson\u2019s Disease"},{"issue":"2","key":"11246_CR23","doi-asserted-by":"publisher","first-page":"2284247","DOI":"10.1080\/19490976.2023.2284247","volume":"15","author":"Y Cheng","year":"2023","unstructured":"Cheng Y, Tan G, Zhu Q, Wang C, Ruan G, Ying S, Qie J, Hu X, Xiao Z, Xu F, Chen L, Chen M, Pei Y, Zhang H, Tian Y, Chen D, Liu X, Huang H, Wei Y (2023) Efficacy of fecal microbiota transplantation in patients with Parkinson\u2019s disease: Clinical trial results from a randomized, placebo-controlled design. Gut Microbes 15(2):2284247. https:\/\/doi.org\/10.1080\/19490976.2023.2284247","journal-title":"Gut Microbes"},{"issue":"1","key":"11246_CR24","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","volume":"11","author":"I Choi","year":"2020","unstructured":"Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z (2020) Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration. Nat Commun 11(1):1386. https:\/\/doi.org\/10.1038\/s41467-020-15119-w","journal-title":"Nat Commun"},{"issue":"1","key":"11246_CR25","doi-asserted-by":"publisher","first-page":"9558","DOI":"10.1038\/s41598-024-59250-w","volume":"14","author":"ZSW Chui","year":"2024","unstructured":"Chui ZSW, Chan LML, Zhang EWH, Liang S, Choi EPH, Lok KYW, Tun HM, Kwok JYY (2024) Effects of microbiome-based interventions on neurodegenerative diseases: A systematic review and meta-analysis. Sci Rep 14(1):9558. https:\/\/doi.org\/10.1038\/s41598-024-59250-w","journal-title":"Sci Rep"},{"issue":"1","key":"11246_CR26","doi-asserted-by":"publisher","first-page":"2371950","DOI":"10.1080\/19490976.2024.2371950","volume":"16","author":"KA Conn","year":"2024","unstructured":"Conn KA, Borsom EM, Cope EK (2024) Implications of microbe-derived \u0263-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer\u2019s disease. Gut Microbes 16(1):2371950. https:\/\/doi.org\/10.1080\/19490976.2024.2371950","journal-title":"Gut Microbes"},{"key":"11246_CR27","doi-asserted-by":"publisher","first-page":"101323","DOI":"10.1016\/j.arr.2021.101323","volume":"68","author":"J Conway","year":"2021","unstructured":"Conway J, Duggal A, N (2021) Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing. Ageing Res Rev 68:101323. https:\/\/doi.org\/10.1016\/j.arr.2021.101323","journal-title":"Ageing Res Rev"},{"issue":"5","key":"11246_CR28","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/ana.25463","volume":"85","author":"JA Cree, Hollenbach","year":"2019","unstructured":"Cree, Hollenbach JA, Bove R, Kirkish G, Sacco S, Caverzasi E, Bischof A, Gundel T, Zhu AH, Papinutto N, Stern WA, Bevan C, Romeo A, Goodin DS, Gelfand JM, Graves J, Green AJ, Wilson MR, Zamvil SS, Hauser SL (2019) Silent progression in disease activity-free relapsing multiple sclerosis. Ann Neurol 85(5):653\u2013666. https:\/\/doi.org\/10.1002\/ana.25463","journal-title":"Ann Neurol"},{"issue":"1","key":"11246_CR29","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegeneration 14(1):32. https:\/\/doi.org\/10.1186\/s13024-019-0333-5","journal-title":"Mol Neurodegeneration"},{"issue":"9","key":"11246_CR30","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.3390\/microorganisms10091838","volume":"10","author":"LMT Dicks","year":"2022","unstructured":"Dicks LMT (2022) Gut bacteria and neurotransmitters. Microorganisms 10(9):1838. https:\/\/doi.org\/10.3390\/microorganisms10091838","journal-title":"Microorganisms"},{"issue":"7","key":"11246_CR31","doi-asserted-by":"publisher","first-page":"e70541","DOI":"10.1111\/cns.70541","volume":"31","author":"Y Du","year":"2025","unstructured":"Du Y, Wang L, Cui Y, Xu X, Zhang M, Li Y, Gao T, Gao D, Sheng Z, Wang S, Tuo H (2025) Effect of probiotics supplementation on REM sleep behavior disorder and motor symptoms in Parkinson\u2019s disease: A Pilot Study. CNS Neurosci Ther 31(7):e70541. https:\/\/doi.org\/10.1111\/cns.70541","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"11246_CR32","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.celrep.2019.09.002","volume":"29","author":"D Duc","year":"2019","unstructured":"Duc D, Vigne S, Bernier-Latmani J, Yersin Y, Ruiz F, Ga\u00efa N, Leo S, Lazarevic V, Schrenzel J, Petrova TV, Pot C (2019) Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis. Cell Rep 29(2):378\u2013390e4. https:\/\/doi.org\/10.1016\/j.celrep.2019.09.002","journal-title":"Cell Rep"},{"key":"11246_CR33","doi-asserted-by":"publisher","first-page":"1104759","DOI":"10.3389\/fneur.2023.1104759","volume":"14","author":"HL DuPont","year":"2023","unstructured":"DuPont HL, Suescun J, Jiang Z-D, Brown EL, Essigmann HT, Alexander AS, DuPont AW, Iqbal T, Utay NS, Newmark M, Schiess MC (2023) Fecal microbiota transplantation in Parkinson\u2019s disease\u2014A randomized repeat-dose, placebo-controlled clinical pilot study. Front Neurol 14:1104759. https:\/\/doi.org\/10.3389\/fneur.2023.1104759","journal-title":"Front Neurol"},{"issue":"7","key":"11246_CR34","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"D Erny","year":"2015","unstructured":"Erny D, Hrab\u011b de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Uterm\u00f6hlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit I, Prinz M (2015) Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 18(7):965\u2013977. https:\/\/doi.org\/10.1038\/nn.4030","journal-title":"Nat Neurosci"},{"key":"11246_CR35","unstructured":"European consensus conference on faecal microbiota transplantation in clinical practice | Gut. (n.d.). Retrieved August 28, (2026) from https:\/\/gut.bmj.com\/content\/66\/4\/569.short"},{"key":"11246_CR36","doi-asserted-by":"publisher","first-page":"111042","DOI":"10.1016\/j.neuropharm.2026.111042","volume":"297","author":"MN Fawzy","year":"2026","unstructured":"Fawzy MN, Abdelaziz AM, Shokr MM, Fathy MK (2026) Targeting the microbiome-NLRP3-ferroptosis axis in multiple sclerosis: Neuropharmacological implications for microglial dysfunction and demyelination. Neuropharmacology 297:111042. https:\/\/doi.org\/10.1016\/j.neuropharm.2026.111042","journal-title":"Neuropharmacology"},{"issue":"1","key":"11246_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12031-026-02490-4","volume":"76","author":"MN Fawzy","year":"2026","unstructured":"Fawzy MN, Fathy MK (2026) Targeting the gut-brain-ferroptosis axis: molecular mechanisms and therapeutic potential in Alzheimer\u2019s disease and epilepsy. J Mol Neuroscience: MN 76(1):42. https:\/\/doi.org\/10.1007\/s12031-026-02490-4","journal-title":"J Mol Neuroscience: MN"},{"issue":"700","key":"11246_CR38","doi-asserted-by":"publisher","first-page":"eabo2984","DOI":"10.1126\/scitranslmed.abo2984","volume":"15","author":"AL Ferreiro","year":"2023","unstructured":"Ferreiro AL, Choi J, Ryou J, Newcomer EP, Thompson R, Bollinger RM, Hall-Moore C, Ndao IM, Sax L, Benzinger TLS, Stark SL, Holtzman DM, Fagan AM, Schindler SE, Cruchaga C, Butt OH, Morris JC, Tarr PI, Ances BM, Dantas G (2023) Gut microbiome composition may be an indicator of preclinical Alzheimer\u2019s disease. Sci Transl Med 15(700):eabo2984. https:\/\/doi.org\/10.1126\/scitranslmed.abo2984","journal-title":"Sci Transl Med"},{"issue":"5","key":"11246_CR39","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1021\/acs.jafc.3c07927","volume":"72","author":"L Filipp","year":"2024","unstructured":"Filipp L, Bausch F, Neuhaus LS, Flade J, Henle T (2024) Metabolization of the Amadori product N-\u03b5-Fructosyllysine by probiotic bacteria. J Agric Food Chem 72(5):2718\u20132726. https:\/\/doi.org\/10.1021\/acs.jafc.3c07927","journal-title":"J Agric Food Chem"},{"key":"11246_CR40","doi-asserted-by":"publisher","first-page":"104714","DOI":"10.1016\/j.nbd.2019.104714","volume":"136","author":"TC Fung","year":"2020","unstructured":"Fung TC (2020) The microbiota-immune axis as a central mediator of gut-brain communication. Neurobiol Dis 136:104714. https:\/\/doi.org\/10.1016\/j.nbd.2019.104714","journal-title":"Neurobiol Dis"},{"issue":"1","key":"11246_CR41","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","volume":"8","author":"C Gao","year":"2023","unstructured":"Gao C, Jiang J, Tan Y, Chen S (2023) Microglia in neurodegenerative diseases: Mechanism and potential therapeutic targets. Signal Transduct Target Therapy 8(1):359. https:\/\/doi.org\/10.1038\/s41392-023-01588-0","journal-title":"Signal Transduct Target Therapy"},{"issue":"4","key":"11246_CR42","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","volume":"23","author":"GBD 2021 Nervous System Disorders Collaborators","year":"2024","unstructured":"GBD 2021 Nervous System Disorders Collaborators (2024) Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol 23(4):344\u2013381. https:\/\/doi.org\/10.1016\/S1474-4422(24)00038-3","journal-title":"Lancet Neurol"},{"key":"11246_CR43","doi-asserted-by":"publisher","unstructured":"Ghezzi L, Cantoni C, Pinget G, Zhou Y, Piccio L (2021) Targeting the gut to treat multiple sclerosis. J Clin Invest 131(13). https:\/\/doi.org\/10.1172\/JCI143774","DOI":"10.1172\/JCI143774"},{"issue":"10","key":"11246_CR44","doi-asserted-by":"publisher","first-page":"e2413953122","DOI":"10.1073\/pnas.2413953122","volume":"122","author":"S Ghimire","year":"2025","unstructured":"Ghimire S, Lehman PC, Aguilar Meza LS, Shahi SK, Hoang J, Olalde H, Paullus M, Cherwin C, Wang K, Gill C, Cho T, Mangalam AK (2025) Specific microbial ratio in the gut microbiome is associated with multiple sclerosis. Proc Natl Acad Sci 122(10):e2413953122. https:\/\/doi.org\/10.1073\/pnas.2413953122","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"11246_CR45","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","volume":"14","author":"GR Gibson","year":"2017","unstructured":"Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8):491\u2013502. https:\/\/doi.org\/10.1038\/nrgastro.2017.75","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"11246_CR46","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.bbi.2004.09.002","volume":"19","author":"LE Goehler","year":"2005","unstructured":"Goehler LE, Gaykema RPA, Opitz N, Reddaway R, Badr N, Lyte M (2005) Activation in vagal afferents and central autonomic pathways: Early responses to intestinal infection with Campylobacter jejuni. Brain Behav Immun 19(4):334\u2013344. https:\/\/doi.org\/10.1016\/j.bbi.2004.09.002","journal-title":"Brain Behav Immun"},{"issue":"12","key":"11246_CR47","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1007\/s10482-020-01474-7","volume":"113","author":"EZ Gomaa","year":"2020","unstructured":"Gomaa EZ (2020) Human gut microbiota\/microbiome in health and diseases: A review. Antonie Van Leeuwenhoek 113(12):2019\u20132040. https:\/\/doi.org\/10.1007\/s10482-020-01474-7","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"10","key":"11246_CR48","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.7150\/ijbs.85259","volume":"19","author":"Y Gong","year":"2023","unstructured":"Gong Y, Chen A, Zhang G, Shen Q, Zou L, Li J, Miao Y-B, Liu W (2023) Cracking brain diseases from gut microbes-mediated metabolites for precise treatment. Int J Biol Sci 19(10):2974\u20132998. https:\/\/doi.org\/10.7150\/ijbs.85259","journal-title":"Int J Biol Sci"},{"issue":"1","key":"11246_CR49","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00441-017-2775-9","volume":"373","author":"V Grozdanov","year":"2018","unstructured":"Grozdanov V, Danzer KM (2018) Release and uptake of pathologic alpha-synuclein. Cell Tissue Res 373(1):175\u2013182. https:\/\/doi.org\/10.1007\/s00441-017-2775-9","journal-title":"Cell Tissue Res"},{"issue":"1","key":"11246_CR50","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1186\/s12951-025-03719-x","volume":"23","author":"YM Hassan","year":"2025","unstructured":"Hassan YM, Wanas A, Ali AA, El-Sayed WM (2025) Integrating artificial intelligence with nanodiagnostics for early detection and precision management of neurodegenerative diseases. J Nanobiotechnol 23(1):668. https:\/\/doi.org\/10.1186\/s12951-025-03719-x","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"11246_CR51","doi-asserted-by":"publisher","first-page":"2554195","DOI":"10.1080\/19490976.2025.2554195","volume":"17","author":"T Hensen","year":"2025","unstructured":"Hensen T, Thiele I (2025) Metabolic modeling links gut microbiota to metabolic markers of Parkinson\u2019s disease. Gut Microbes 17(1):2554195. https:\/\/doi.org\/10.1080\/19490976.2025.2554195","journal-title":"Gut Microbes"},{"issue":"1","key":"11246_CR52","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s12035-025-05321-6","volume":"63","author":"HF Hetta","year":"2026","unstructured":"Hetta HF, Alanazi FE, Alqifari SF, Ali MAS, Albalwi MA, Albalawi AA, Ramadan YN (2026) The gut\u2013brain axis in autism: inflammatory mechanisms, molecular insights, and emerging microbiome-based therapies. Mol Neurobiol 63(1):211. https:\/\/doi.org\/10.1007\/s12035-025-05321-6","journal-title":"Mol Neurobiol"},{"issue":"4","key":"11246_CR53","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3390\/immuno4040026","volume":"4","author":"HF Hetta","year":"2024","unstructured":"Hetta HF, Ramadan YN, Alharbi AA, Alsharef S, Alkindy TT, Alkhamali A, Albalawi AS, Amin E, H (2024) Gut microbiome as a target of intervention in inflammatory bowel disease pathogenesis and therapy. Immuno 4(4):400\u2013425. https:\/\/doi.org\/10.3390\/immuno4040026","journal-title":"Immuno"},{"issue":"4","key":"11246_CR54","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/diseases13040115","volume":"13","author":"HF Hetta","year":"2025","unstructured":"Hetta HF, Sirag N, Elfadil H, Salama A, Aljadrawi SF, Alfaifi AJ, Alwabisi AN, AbuAlhasan BM, Alanazi LS, Aljohani YA, Ramadan YN, Ellah A, N. H., Algammal AM (2025) Artificial sweeteners: a double-edged sword for gut microbiome. Diseases 13(4):115. https:\/\/doi.org\/10.3390\/diseases13040115","journal-title":"Diseases"},{"issue":"8","key":"11246_CR55","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11(8):506\u2013514. https:\/\/doi.org\/10.1038\/nrgastro.2014.66","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7","key":"11246_CR56","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/jamaneurol.2023.1135","volume":"80","author":"M Hittle","year":"2023","unstructured":"Hittle M, Culpepper WJ, Langer-Gould A, Marrie RA, Cutter GR, Kaye WE, Wagner L, Topol B, LaRocca NG, Nelson LM, Wallin MT (2023) Population-based estimates for the prevalence of multiple sclerosis in the united states by race, ethnicity, age, sex, and geographic region. JAMA Neurol 80(7):693\u2013701. https:\/\/doi.org\/10.1001\/jamaneurol.2023.1135","journal-title":"JAMA Neurol"},{"issue":"1","key":"11246_CR57","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","volume":"7","author":"K Hou","year":"2022","unstructured":"Hou K, Wu Z-X, Chen X-Y, Wang J-Q, Zhang D, Xiao C, Zhu D, Koya JB, Wei L, Li J, Chen Z-S (2022) Microbiota in health and diseases. Signal Transduct Target Therapy 7(1):135. https:\/\/doi.org\/10.1038\/s41392-022-00974-4","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"11246_CR58","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","volume":"3","author":"MC Houser","year":"2017","unstructured":"Houser MC, Tansey MG (2017) The gut-brain axis: Is intestinal inflammation a silent driver of Parkinson\u2019s disease pathogenesis? Npj Parkinson\u2019s Disease 3(1):3. https:\/\/doi.org\/10.1038\/s41531-016-0002-0","journal-title":"Npj Parkinson\u2019s Disease"},{"issue":"2","key":"11246_CR59","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s40572-017-0142-3","volume":"4","author":"RL Jayaraj","year":"2017","unstructured":"Jayaraj RL, Rodriguez EA, Wang Y, Block ML (2017) Outdoor ambient air pollution and neurodegenerative diseases: the neuroinflammation hypothesis. Curr Environ Health Rep 4(2):166\u2013179. https:\/\/doi.org\/10.1007\/s40572-017-0142-3","journal-title":"Curr Environ Health Rep"},{"issue":"1","key":"11246_CR60","doi-asserted-by":"publisher","first-page":"29924","DOI":"10.1038\/s41598-025-15355-4","volume":"15","author":"N Jouni","year":"2025","unstructured":"Jouni N, Akhgarjand C, Vahabi Z, Shab-Bidar S, Khalifeh H, Djafarian K (2025) Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer\u2019s disease: A randomized, double blind, placebo controlled trial. Sci Rep 15(1):29924. https:\/\/doi.org\/10.1038\/s41598-025-15355-4","journal-title":"Sci Rep"},{"key":"11246_CR61","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neuroscience.2025.11.019","volume":"591","author":"FH Jouriani","year":"2025","unstructured":"Jouriani FH, Gholizadeh Khiavi A, Beglari EH, Rezaie S, Aghamohammad N, S., Rohani M (2025) Neuroprotective and antioxidant potential of probiotics in countering nickel-induced oxidative stress in the brain. Neuroscience 591:110\u2013115. https:\/\/doi.org\/10.1016\/j.neuroscience.2025.11.019","journal-title":"Neuroscience"},{"issue":"3","key":"11246_CR62","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1002\/cphy.c140065","volume":"5","author":"M Keller-Wood","year":"2015","unstructured":"Keller-Wood M (2015) Hypothalamic-Pituitary\u2014Adrenal Axis-Feedback Control. Compr Physiol 5(3):1161\u20131182. https:\/\/doi.org\/10.1002\/cphy.c140065","journal-title":"Compr Physiol"},{"key":"11246_CR63","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2024.k.0267","author":"B-H Kim","year":"2025","unstructured":"Kim B-H, Kwon M, Yim S-V, Park J-W, Lee C-N, Chae S-W, Choi JG, Park SC, Sohn MW, Choi SZ, Lee JS (2025) Efficacy and safety of MT104, a dietary supplement based on cuscuta seeds and heat-killed probiotics, on cognitive function in patients with mild cognitive impairment: a 12-week, multicenter, randomized, double-blind, placebo-controlled clinical trial. J Med Food. (140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA) https:\/\/doi.org\/10.1089\/jmf.2024.k.0267","journal-title":"J Med Food"},{"key":"11246_CR64","doi-asserted-by":"publisher","first-page":"782082","DOI":"10.3389\/fnagi.2021.782082","volume":"13","author":"EM Klann","year":"2021","unstructured":"Klann EM, Dissanayake U, Gurrala A, Farrer M, Wagle Shukla A, Ramirez-Zamora A, Mai V, Vedam-Mai V (2021) The gut-brain axis and its relation to Parkinson\u2019s disease: a review. Front Aging Neurosci 13:782082. https:\/\/doi.org\/10.3389\/fnagi.2021.782082","journal-title":"Front Aging Neurosci"},{"issue":"23","key":"11246_CR65","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.3390\/cells11233795","volume":"11","author":"T K\u00f6rt\u00e9si","year":"2022","unstructured":"K\u00f6rt\u00e9si T, Spekker E, V\u00e9csei L (2022) Exploring the tryptophan metabolic pathways in migraine-related mechanisms. Cells 11(23):3795. https:\/\/doi.org\/10.3390\/cells11233795","journal-title":"Cells"},{"issue":"7900","key":"11246_CR66","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41586-022-04432-7","volume":"603","author":"TV Lanz","year":"2022","unstructured":"Lanz TV, Brewer RC, Ho PP, Moon J-S, Jude KM, Fernandez D, Fernandes RA, Gomez AM, Nadj G-S, Bartley CM, Schubert RD, Hawes IA, Vazquez SE, Iyer M, Zuchero JB, Teegen B, Dunn JE, Lock CB, Kipp LB, Robinson WH (2022) Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature 603(7900):321\u2013327. https:\/\/doi.org\/10.1038\/s41586-022-04432-7","journal-title":"Nature"},{"issue":"3","key":"11246_CR67","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10096-019-03721-w","volume":"39","author":"Q Le Bastard","year":"2020","unstructured":"Le Bastard Q, Chapelet G, Javaudin F, Lepelletier D, Batard E, Montassier E (2020) The effects of inulin on gut microbial composition: A systematic review of evidence from human studies. Eur J Clin Microbiol Infect Dis 39(3):403\u2013413. https:\/\/doi.org\/10.1007\/s10096-019-03721-w","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"52","key":"11246_CR68","doi-asserted-by":"publisher","first-page":"36406","DOI":"10.1074\/jbc.M803519200","volume":"283","author":"AC LeBoeuf","year":"2008","unstructured":"LeBoeuf AC, Levy SF, Gaylord M, Bhattacharya A, Singh AK, Jordan MA, Wilson L, Feinstein SC (2008) FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: An alternative core model for normal and pathological Tau action. J Biol Chem 283(52):36406\u201336415. https:\/\/doi.org\/10.1074\/jbc.M803519200","journal-title":"J Biol Chem"},{"issue":"12","key":"11246_CR69","doi-asserted-by":"publisher","first-page":"e2170024","DOI":"10.1002\/mnfr.202170024","volume":"65","author":"H-J Lee","year":"2021","unstructured":"Lee H-J, Hwang Y-H, Kim D-H (2021) Lactobacillus plantarum C29-Fermented Soybean (DW2009) alleviates memory impairment in 5XFAD transgenic mice by regulating microglia activation and gut microbiota composition. Mol Nutr Food Res 65(12):e2170024. https:\/\/doi.org\/10.1002\/mnfr.202170024","journal-title":"Mol Nutr Food Res"},{"issue":"12","key":"11246_CR70","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.1002\/mds.70047","volume":"40","author":"V Leta","year":"2025","unstructured":"Leta V, Zinzalias P, Batzu L, Mandal G, Staunton J, Jernstedt F, Rosqvist K, Timpka J, van Vliet T, Trivedi D, Podlewska A, Parry M, van Wamelen DJ, Rizos A, Sportelli C, Bonder AL, Chung-Faye G, Falup-Pecurariu C, Gaisford S, Ray Chaudhuri K (2025a) Effects of a four-strain probiotic on gut microbiota, inflammation, and symptoms in Parkinson\u2019s disease: a randomized clinical trial. Mov Disorders: Official J Mov Disorder Soc 40(12):2710\u20132721. https:\/\/doi.org\/10.1002\/mds.70047","journal-title":"Mov Disorders: Official J Mov Disorder Soc"},{"key":"11246_CR71","doi-asserted-by":"publisher","DOI":"10.1002\/mds.70047","author":"V Leta","year":"2025","unstructured":"Leta V, Zinzalias P, Batzu L, Mandal G, Staunton J, Jernstedt F, Rosqvist K, Timpka J, van Vliet T, Trivedi D, Podlewska A, Parry M, van Wamelen DJ, Rizos A, Sportelli C, Bonder AL, Chung-Faye G, Falup-Pecurariu C, Gaisford S, Ray Chaudhuri K (2025b) Effects of a four-strain probiotic on gut microbiota, inflammation, and symptoms in parkinson\u2019s disease: a randomized clinical Trial. Mov Disorders: Official J Mov Disorder Soc. https:\/\/doi.org\/10.1002\/mds.70047","journal-title":"Mov Disorders: Official J Mov Disorder Soc"},{"key":"11246_CR72","doi-asserted-by":"publisher","first-page":"8163789","DOI":"10.1155\/2020\/8163789","volume":"2020","author":"J Li","year":"2020","unstructured":"Li J, Zhang K, Zhang Q, Zhou X, Wen L, Ma J, Niu L, Li C (2020) PPAR-\u03b3 Mediates Ta-VNS-Induced angiogenesis and subsequent functional recovery after experimental stroke in rats. Biomed Res Int 2020:8163789. https:\/\/doi.org\/10.1155\/2020\/8163789","journal-title":"Biomed Res Int"},{"issue":"15","key":"11246_CR73","doi-asserted-by":"publisher","first-page":"7865","DOI":"10.1039\/D4FO00886C","volume":"15","author":"L Li","year":"2024","unstructured":"Li L, Yang C, Jia M, Wang Y, Zhao Y, Li Q, Gong J, He Y, Xu K, Liu X, Chen X, Hu J, Liu Z (2024) Synbiotic therapy with Clostridium sporogenes and xylan promotes gut-derived indole-3-propionic acid and improves cognitive impairments in an Alzheimer\u2019s disease mouse model. Food Funct 15(15):7865\u20137882. https:\/\/doi.org\/10.1039\/D4FO00886C","journal-title":"Food Funct"},{"key":"11246_CR74","doi-asserted-by":"publisher","unstructured":"Li M, van Esch BCAM, Henricks PAJ, Folkerts G, Garssen J (2018) The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor \u03b1-stimulated endothelial cells via activation of GPR41\/43 and inhibition of HDACs. Front Pharmacol 9. https:\/\/doi.org\/10.3389\/fphar.2018.00533","DOI":"10.3389\/fphar.2018.00533"},{"issue":"1","key":"11246_CR75","doi-asserted-by":"publisher","first-page":"2402547","DOI":"10.1080\/19490976.2024.2402547","volume":"16","author":"N Li","year":"2024","unstructured":"Li N, Han X, Ruan M, Huang F, Yang L, Xu T, Wang H, Wu H, Shi S, Wang Y, Wu X, Wang S (2024) Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids. Gut Microbes 16(1):2402547. https:\/\/doi.org\/10.1080\/19490976.2024.2402547","journal-title":"Gut Microbes"},{"key":"11246_CR76","doi-asserted-by":"publisher","unstructured":"Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore CS, Michel L, Althekair F, Rajasekharan S, Gommerman JL, Prat A, Fillatreau S, Bar-Or A & Canadian B cells in MS Team. (2015). Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Sci Transl Med, 7(310), 310ra166. https:\/\/doi.org\/10.1126\/scitranslmed.aab4176","DOI":"10.1126\/scitranslmed.aab4176"},{"issue":"5","key":"11246_CR77","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/foods14050813","volume":"14","author":"W Li","year":"2025","unstructured":"Li W, Xu M, Liu Y, Zhang S, Wang J, Zhang Z, Xiao G, Wang R, Zhang J, Xue H (2025) Lactiplantibacillus plantarum GOLDGUT-HNU082 Alleviates CUMS-Induced depressive-like behaviors in mice by modulating the gut microbiota and neurotransmitter levels. Foods 14(5):813. https:\/\/doi.org\/10.3390\/foods14050813","journal-title":"Foods"},{"issue":"1","key":"11246_CR78","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/cns.13990","volume":"29","author":"Z Li","year":"2023","unstructured":"Li Z, Liang H, Hu Y, Lu L, Zheng C, Fan Y, Wu B, Zou T, Luo X, Zhang X, Zeng Y, Liu Z, Zhou Z, Yue Z, Ren Y, Li Z, Su Q, Xu P (2023) Gut bacterial profiles in Parkinson\u2019s disease: A systematic review. CNS Neurosci Ther 29(1):140\u2013157. https:\/\/doi.org\/10.1111\/cns.13990","journal-title":"CNS Neurosci Ther"},{"issue":"7638","key":"11246_CR79","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, M\u00fcnch AE, Chung W-S, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Barres BA (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541(7638):481\u2013487. https:\/\/doi.org\/10.1038\/nature21029","journal-title":"Nature"},{"issue":"12","key":"11246_CR80","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1007\/s12035-020-02073-3","volume":"57","author":"S Liu","year":"2020","unstructured":"Liu S, Gao J, Zhu M, Liu K, Zhang H-L (2020) Gut microbiota and dysbiosis in Alzheimer\u2019s disease: implications for pathogenesis and treatment. Mol Neurobiol 57(12):5026\u20135043. https:\/\/doi.org\/10.1007\/s12035-020-02073-3","journal-title":"Mol Neurobiol"},{"key":"11246_CR81","doi-asserted-by":"publisher","first-page":"116413","DOI":"10.1016\/j.carbpol.2020.116413","volume":"242","author":"W Liu","year":"2020","unstructured":"Liu W, Li X, Zhao Z, Pi X, Meng Y, Fei D, Liu D, Wang X (2020) Effect of chitooligosaccharides on human gut microbiota and antiglycation. Carbohydr Polym 242:116413. https:\/\/doi.org\/10.1016\/j.carbpol.2020.116413","journal-title":"Carbohydr Polym"},{"issue":"1","key":"11246_CR82","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40035-026-00542-8","volume":"15","author":"Z Liu","year":"2026","unstructured":"Liu Z, Nie J, Li Y, Huang M, Chen Z, Yu S, Zheng J, Tan Y, Chen S (2026) Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinson\u2019s disease mouse model by modulating gut microbiota dysbiosis and inhibiting the NLRP3 signaling pathway. Translational Neurodegeneration 15(1):7. https:\/\/doi.org\/10.1186\/s40035-026-00542-8","journal-title":"Translational Neurodegeneration"},{"issue":"2","key":"11246_CR83","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1177\/13872877251345157","volume":"106","author":"L Loffredo","year":"2025","unstructured":"Loffredo L, Alfano AR, Ettorre E, Desideri G, Carnevale R, Forte M, Maglione V, Bartimoccia S, Castellani V, Tot\u00e8 CM, Pignatelli P, Violi F, Neurodegenerative Disease study group (2025) Effect of the probiotic Escherichia coli Nissle 1917 on serum levels of NADPH oxidase-2 and lipopolysaccharide in patients with Alzheimer\u2019s disease. J Alzheimer\u2019s Disease: JAD 106(2):774\u2013782. https:\/\/doi.org\/10.1177\/13872877251345157","journal-title":"J Alzheimer\u2019s Disease: JAD"},{"key":"11246_CR84","doi-asserted-by":"publisher","first-page":"107974","DOI":"10.1016\/j.phrs.2025.107974","volume":"221","author":"S Luo","year":"2025","unstructured":"Luo S, Pan M, Fu G, Meng X, Zhao Z, Yu H, Yue G, Lei T (2025) Vagus nerve and brain-gut communication in neurodegenerative diseases: Mechanism and therapeutic perspectives. Pharmacol Res 221:107974. https:\/\/doi.org\/10.1016\/j.phrs.2025.107974","journal-title":"Pharmacol Res"},{"issue":"1","key":"11246_CR85","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40035-024-00404-1","volume":"13","author":"Y-Y Ma","year":"2024","unstructured":"Ma Y-Y, Li X, Yu J-T, Wang Y-J (2024) Therapeutics for neurodegenerative diseases by targeting the gut microbiome: From bench to bedside. Translational Neurodegeneration 13(1):12. https:\/\/doi.org\/10.1186\/s40035-024-00404-1","journal-title":"Translational Neurodegeneration"},{"key":"11246_CR86","doi-asserted-by":"publisher","first-page":"106138","DOI":"10.1016\/j.bbi.2025.106138","volume":"131","author":"M Marizzoni","year":"2025","unstructured":"Marizzoni M, Mombelli E, Alboni S, Rosa M, Moretti DV, Mirabelli P, Coppola L, Luongo D, Salamone D, Saleri S, Piazza F, Begni V, Salvatore M, Frisoni GB, Cattaneo A (2025) Microbiota-gut-brain axis dysregulation in Alzheimer\u2019s disease and its modulation through probiotic supplementation. Brain Behav Immun 131:106138. https:\/\/doi.org\/10.1016\/j.bbi.2025.106138","journal-title":"Brain Behav Immun"},{"issue":"13","key":"11246_CR87","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1097\/01.MIB.0000435444.14860.ea","volume":"19","author":"R Masui","year":"2013","unstructured":"Masui R, Sasaki M, Funaki Y, Ogasawara N, Mizuno M, Iida A, Izawa S, Kondo Y, Ito Y, Tamura Y, Yanamoto K, Noda H, Tanabe A, Okaniwa N, Yamaguchi Y, Iwamoto T, Kasugai K (2013) G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells. Inflamm Bowel Dis 19(13):2848\u20132856. https:\/\/doi.org\/10.1097\/01.MIB.0000435444.14860.ea","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"11246_CR88","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1038\/s41380-023-01972-w","volume":"28","author":"EA Mayer","year":"2023","unstructured":"Mayer EA, Ryu HJ, Bhatt RR (2023) The neurobiology of irritable bowel syndrome. Mol Psychiatry 28(4):1451\u20131465. https:\/\/doi.org\/10.1038\/s41380-023-01972-w","journal-title":"Mol Psychiatry"},{"key":"11246_CR89","doi-asserted-by":"publisher","first-page":"111661","DOI":"10.1016\/j.biopha.2021.111661","volume":"139","author":"R Mirzaei","year":"2021","unstructured":"Mirzaei R, Bouzari B, Hosseini-Fard SR, Mazaheri M, Ahmadyousefi Y, Abdi M, Jalalifar S, Karimitabar Z, Teimoori A, Keyvani H, Zamani F, Yousefimashouf R, Karampoor S (2021) Role of microbiota-derived short-chain fatty acids in nervous system disorders. Biomed Pharmacotherapy = Biomedecine Pharmacotherapie 139:111661. https:\/\/doi.org\/10.1016\/j.biopha.2021.111661","journal-title":"Biomed Pharmacotherapy = Biomedecine Pharmacotherapie"},{"issue":"1","key":"11246_CR90","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s40168-022-01408-7","volume":"10","author":"TL Montgomery","year":"2022","unstructured":"Montgomery TL, Eckstrom K, Lile KH, Caldwell S, Heney ER, Lahue KG, D\u2019Alessandro A, Wargo MJ, Krementsov DN (2022) Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity. Microbiome 10(1):198. https:\/\/doi.org\/10.1186\/s40168-022-01408-7","journal-title":"Microbiome"},{"issue":"11","key":"11246_CR91","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1080\/1028415X.2022.2128010","volume":"26","author":"AR Moravejolahkami","year":"2023","unstructured":"Moravejolahkami AR, Chitsaz A, Hassanzadeh A, Paknahad Z (2023) Effects of anti-Inflammatory-antioxidant-rich diet and co-supplemented synbiotics intervention in patients with progressive forms of multiple sclerosis: A single-center, single-blind randomized clinical trial. Nutr Neurosci 26(11):1078\u20131089. https:\/\/doi.org\/10.1080\/1028415X.2022.2128010","journal-title":"Nutr Neurosci"},{"issue":"10423","key":"11246_CR92","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","volume":"403","author":"HR Morris","year":"2024","unstructured":"Morris HR, Spillantini MG, Sue CM, Williams-Gray CH (2024) The pathogenesis of Parkinson\u2019s disease. Lancet (London England) 403(10423):293\u2013304. https:\/\/doi.org\/10.1016\/S0140-6736(23)01478-2","journal-title":"Lancet (London England)"},{"key":"11246_CR93","doi-asserted-by":"publisher","first-page":"796288","DOI":"10.3389\/fimmu.2022.796288","volume":"13","author":"Y Mou","year":"2022","unstructured":"Mou Y, Du Y, Zhou L, Yue J, Hu X, Liu Y, Chen S, Lin X, Zhang G, Xiao H, Dong B (2022) Gut microbiota interact with the brain through systemic chronic inflammation: implications on neuroinflammation, neurodegeneration, and aging. Front Immunol 13:796288. https:\/\/doi.org\/10.3389\/fimmu.2022.796288","journal-title":"Front Immunol"},{"issue":"1","key":"11246_CR94","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s40520-024-02729-3","volume":"36","author":"F Nabizadeh","year":"2024","unstructured":"Nabizadeh F, Valizadeh P, Fallahi MS, Alzheimer\u2019s disease Neuroimaging Initiative (2024) Bile acid profile associated with CSF and PET biomarkers in Alzheimer\u2019s disease. Aging Clin Exp Res 36(1):62. https:\/\/doi.org\/10.1007\/s40520-024-02729-3","journal-title":"Aging Clin Exp Res"},{"issue":"3","key":"11246_CR95","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3233\/jpd-191627","volume":"9","author":"B Ni","year":"2019","unstructured":"Ni B, Mtm H (2019) Sleep Disturbance as Potential Risk and Progression Factor for Parkinson\u2019s Disease. J Parkinson\u2019s Disease 9(3):603\u2013614. https:\/\/doi.org\/10.3233\/jpd-191627","journal-title":"J Parkinson\u2019s Disease"},{"issue":"1","key":"11246_CR96","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1186\/s12916-025-04488-y","volume":"23","author":"J Ni","year":"2025","unstructured":"Ni J, Hern\u00e1ndez-Cacho A, Nishi SK, Babio N, Belzer C, Konstati P, Vioque J, Corella D, Casta\u00f1er O, Vidal J, Moreno-Indias I, Torres-Collado L, Coltell O, Fit\u00f3 M, Ruiz-Canela M, Wang DD, Tinahones FJ, Salas-Salvad\u00f3 J (2025) Mediterranean diet, gut microbiota, and cognitive decline in older adults with obesity\/overweight and metabolic syndrome: A prospective cohort study. BMC Med 23(1):669. https:\/\/doi.org\/10.1186\/s12916-025-04488-y","journal-title":"BMC Med"},{"key":"11246_CR97","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.clnesp.2025.03.002","volume":"67","author":"FO Okunlola","year":"2025","unstructured":"Okunlola FO, Okunlola AR, Adetuyi BO, Soliman MES, Alexiou A, Papadakis M, Fawzy MN, Batiha E-S, G (2025) Beyond the gut: Unraveling the multifaceted influence of microbiome on cardiovascular health. Clin Nutr ESPEN 67:71\u201389. https:\/\/doi.org\/10.1016\/j.clnesp.2025.03.002","journal-title":"Clin Nutr ESPEN"},{"issue":"5","key":"11246_CR98","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.3390\/ijerph20054624","volume":"20","author":"A Ordo\u00f1ez-Rodriguez","year":"2023","unstructured":"Ordo\u00f1ez-Rodriguez A, Roman P, Rueda-Ruzafa L, Campos-Rios A, Cardona D (2023) Changes in gut microbiota and multiple sclerosis: a systematic review. Int J Environ Res Public Health 20(5):4624. https:\/\/doi.org\/10.3390\/ijerph20054624","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"11246_CR99","doi-asserted-by":"publisher","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"W Poewe","year":"2017","unstructured":"Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag A-E, Lang AE (2017) Parkinson disease. Nat Reviews Disease Primers 3(1):17013. https:\/\/doi.org\/10.1038\/nrdp.2017.13","journal-title":"Nat Reviews Disease Primers"},{"issue":"5","key":"11246_CR100","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.chom.2023.03.020","volume":"31","author":"S Porcari","year":"2023","unstructured":"Porcari S, Benech N, Valles-Colomer M, Segata N, Gasbarrini A, Cammarota G, Sokol H, Ianiro G (2023) Key determinants of success in fecal microbiota transplantation: From microbiome to clinic. Cell Host Microbe 31(5):712\u2013733. https:\/\/doi.org\/10.1016\/j.chom.2023.03.020","journal-title":"Cell Host Microbe"},{"issue":"53","key":"11246_CR101","doi-asserted-by":"publisher","first-page":"eabc7191","DOI":"10.1126\/sciimmunol.abc7191","volume":"5","author":"A-K Pr\u00f6bstel","year":"2020","unstructured":"Pr\u00f6bstel A-K, Zhou X, Baumann R, Wischnewski S, Kutza M, Rojas OL, Sellrie K, Bischof A, Kim K, Ramesh A, Dandekar R, Greenfield AL, Schubert RD, Bisanz JE, Vistnes S, Khaleghi K, Landefeld J, Kirkish G, Liesche-Starnecker F, Baranzini SE (2020) Gut microbiota-specific IgA\u2009+\u2009B cells traffic to the CNS in active multiple sclerosis. Sci Immunol 5(53):eabc7191. https:\/\/doi.org\/10.1126\/sciimmunol.abc7191","journal-title":"Sci Immunol"},{"issue":"23","key":"11246_CR102","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.3390\/molecules25235773","volume":"25","author":"R Purgatorio","year":"2020","unstructured":"Purgatorio R, Gambacorta N, Catto M, de Candia M, Pisani L, Espargar\u00f3 A, Sabat\u00e9 R, Cellamare S, Nicolotti O, Altomare CD (2020) Pharmacophore modeling and 3D-QSAR study of indole and isatin derivatives as antiamyloidogenic agents targeting Alzheimer\u2019s disease. Molecules 25(23):5773. https:\/\/doi.org\/10.3390\/molecules25235773","journal-title":"Molecules"},{"key":"11246_CR103","doi-asserted-by":"publisher","unstructured":"Qin R, Li C, Yuan X, Chen Y (2025) Microbiome-targeted Alzheimer\u2019s interventions via gut-brain axis. Front Microbiol 16. https:\/\/doi.org\/10.3389\/fmicb.2025.1729708","DOI":"10.3389\/fmicb.2025.1729708"},{"issue":"2","key":"11246_CR104","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1080\/1028415X.2020.1758887","volume":"25","author":"M Rahimlou","year":"2022","unstructured":"Rahimlou M, Hosseini SA, Majdinasab N, Haghighizadeh MH, Husain D (2022) Effects of long-term administration of Multi-Strain Probiotic on circulating levels of BDNF, NGF, IL-6 and mental health in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled trial. Nutr Neurosci 25(2):411\u2013422. https:\/\/doi.org\/10.1080\/1028415X.2020.1758887","journal-title":"Nutr Neurosci"},{"issue":"8","key":"11246_CR105","doi-asserted-by":"publisher","first-page":"10813","DOI":"10.1007\/s12035-025-04846-0","volume":"62","author":"YN Ramadan","year":"2025","unstructured":"Ramadan YN, Alqifari SF, Alshehri K, Alhowiti A, Mirghani H, Alrasheed T, Aljohani F, Alghamdi A, Hetta HF (2025) Microbiome gut-brain-axis: impact on brain development and mental health. Mol Neurobiol 62(8):10813\u201310833. https:\/\/doi.org\/10.1007\/s12035-025-04846-0","journal-title":"Mol Neurobiol"},{"issue":"10","key":"11246_CR106","doi-asserted-by":"publisher","first-page":"116326","DOI":"10.1016\/j.celrep.2025.116326","volume":"44","author":"J Rebeaud","year":"2025","unstructured":"Rebeaud J, Vigne S, Bressoud V, Carre R, Ruiz F, Peter B, Phillips NE, Siewert L, Roloff T, Egli A, Kuhle J, Collet T-H, Pr\u00f6bstel AK, Pot C (2025) Gut-derived metabolites drive Th17 cell pathogenicity in multiple sclerosis. Cell Rep 44(10):116326. https:\/\/doi.org\/10.1016\/j.celrep.2025.116326","journal-title":"Cell Rep"},{"issue":"5","key":"11246_CR107","doi-asserted-by":"publisher","first-page":"101543","DOI":"10.1016\/j.xcrm.2024.101543","volume":"5","author":"Z Ren","year":"2024","unstructured":"Ren Z, Zhao L, Zhao M, Bao T, Chen T, Zhao A, Zheng X, Gu X, Sun T, Guo Y, Tang Y, Xie G, Jia W (2024) Increased intestinal bile acid absorption contributes to age-related cognitive impairment. Cell Rep Med 5(5):101543. https:\/\/doi.org\/10.1016\/j.xcrm.2024.101543","journal-title":"Cell Rep Med"},{"issue":"17","key":"11246_CR108","doi-asserted-by":"publisher","first-page":"9279","DOI":"10.3390\/ijms25179279","volume":"25","author":"L Romero-Ram\u00edrez","year":"2024","unstructured":"Romero-Ram\u00edrez L, Mey J (2024) Emerging roles of bile acids and TGR5 in the central nervous system: molecular functions and therapeutic implications. Int J Mol Sci 25(17):9279. https:\/\/doi.org\/10.3390\/ijms25179279","journal-title":"Int J Mol Sci"},{"key":"11246_CR109","doi-asserted-by":"publisher","first-page":"S199","DOI":"10.1016\/S1353-8020(11)70062-1","volume":"18","author":"GW Ross","year":"2012","unstructured":"Ross GW, Abbott RD, Petrovitch H, Tanner CM, White LR (2012) Pre-motor features of Parkinson\u2019s disease: The Honolulu-Asia Aging Study experience. Parkinsonism Relat Disorders Proc WFN XIX World Congress Parkinson\u2019s Disease Relat Disorders 18:S199\u2013S202. https:\/\/doi.org\/10.1016\/S1353-8020(11)70062-1","journal-title":"Parkinsonism Relat Disorders Proc WFN XIX World Congress Parkinson\u2019s Disease Relat Disorders"},{"issue":"2","key":"11246_CR110","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s12276-021-00561-7","volume":"53","author":"W Rungratanawanich","year":"2021","unstructured":"Rungratanawanich W, Qu Y, Wang X, Essa MM, Song B-J (2021) Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury. Exp Mol Med 53(2):168\u2013188. https:\/\/doi.org\/10.1038\/s12276-021-00561-7","journal-title":"Exp Mol Med"},{"issue":"1","key":"11246_CR111","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/s41598-018-38218-7","volume":"9","author":"N Saji","year":"2019","unstructured":"Saji N, Niida S, Murotani K, Hisada T, Tsuduki T, Sugimoto T, Kimura A, Toba K, Sakurai T (2019) Analysis of the relationship between the gut microbiome and dementia: A cross-sectional study conducted in Japan. Sci Rep 9(1):1008. https:\/\/doi.org\/10.1038\/s41598-018-38218-7","journal-title":"Sci Rep"},{"issue":"6","key":"11246_CR112","doi-asserted-by":"publisher","first-page":"e200638","DOI":"10.1212\/NXI.0000000000200638","volume":"13","author":"A S\u00e1nchez-Sanz","year":"2026","unstructured":"S\u00e1nchez-Sanz A, Baranzini SE (2026) The Gut Microbiome in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflammation 13(6):e200638. https:\/\/doi.org\/10.1212\/NXI.0000000000200638","journal-title":"Neurol Neuroimmunol Neuroinflammation"},{"issue":"9","key":"11246_CR113","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1001\/jamaneurol.2024.2305","volume":"81","author":"F Scheperjans","year":"2024","unstructured":"Scheperjans F, Levo R, Bosch B, L\u00e4\u00e4peri M, Pereira PAB, Smolander O-P, Aho VTE, Vetkas N, Toivio L, Kainulainen V, Fedorova TD, Lahtinen P, Ortiz R, Kaasinen V, Satokari R, Arkkila P (2024) Fecal microbiota transplantation for treatment of Parkinson disease: a randomized clinical trial. JAMA Neurol 81(9):925\u2013938. https:\/\/doi.org\/10.1001\/jamaneurol.2024.2305","journal-title":"JAMA Neurol"},{"issue":"1","key":"11246_CR114","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S1474-4422(14)70287-X","volume":"14","author":"A Schrag","year":"2015","unstructured":"Schrag A, Horsfall L, Walters K, Noyce A, Petersen I (2015) Prediagnostic presentations of Parkinson\u2019s disease in primary care: A case-control study. Lancet Neurol 14(1):57\u201364. https:\/\/doi.org\/10.1016\/S1474-4422(14)70287-X","journal-title":"Lancet Neurol"},{"issue":"6","key":"11246_CR115","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1080\/19490976.2017.1349041","volume":"8","author":"SK Shahi","year":"2017","unstructured":"Shahi SK, Freedman SN, Mangalam AK (2017) Gut microbiome in multiple sclerosis: The players involved and the roles they play. Gut Microbes 8(6):607\u2013615. https:\/\/doi.org\/10.1080\/19490976.2017.1349041","journal-title":"Gut Microbes"},{"key":"11246_CR116","doi-asserted-by":"publisher","first-page":"636545","DOI":"10.3389\/fnagi.2021.636545","volume":"13","author":"T Shen","year":"2021","unstructured":"Shen T, Yue Y, He T, Huang C, Qu B, Lv W, Lai H-Y (2021) The association between the gut microbiota and Parkinson\u2019s disease, a meta-analysis. Front Aging Neurosci 13:636545. https:\/\/doi.org\/10.3389\/fnagi.2021.636545","journal-title":"Front Aging Neurosci"},{"key":"11246_CR117","doi-asserted-by":"publisher","first-page":"1795042","DOI":"10.3389\/fimmu.2026.1795042","volume":"17","author":"X Shen","year":"2026","unstructured":"Shen X, Zheng C, Lin R, Wang J, Chen Z (2026) Mechanisms and therapeutic advances of gut metabolites in the regulation of neuroimmune inflammatory diseases. Front Immunol 17:1795042. https:\/\/doi.org\/10.3389\/fimmu.2026.1795042","journal-title":"Front Immunol"},{"issue":"1","key":"11246_CR118","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13195-022-00977-x","volume":"14","author":"C Sheng","year":"2022","unstructured":"Sheng C, Yang K, He B, Du W, Cai Y, Han Y (2022) Combination of gut microbiota and plasma amyloid-\u03b2 as a potential index for identifying preclinical Alzheimer\u2019s disease: A cross-sectional analysis from the SILCODE study. Alzheimer\u2019s Res Therapy 14(1):35. https:\/\/doi.org\/10.1186\/s13195-022-00977-x","journal-title":"Alzheimer\u2019s Res Therapy"},{"issue":"4","key":"11246_CR119","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3390\/nu5041417","volume":"5","author":"J Slavin","year":"2013","unstructured":"Slavin J (2013) Fiber and prebiotics: Mechanisms and health benefits. Nutrients 5(4):1417\u20131435. https:\/\/doi.org\/10.3390\/nu5041417","journal-title":"Nutrients"},{"key":"11246_CR120","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.tifs.2022.10.019","volume":"129","author":"Z Song","year":"2022","unstructured":"Song Z, Cheng L, Liu Y, Zhan S, Wu Z, Zhang X (2022) Plant-derived bioactive components regulate gut microbiota to prevent depression and depressive-related neurodegenerative diseases: Focus on neurotransmitters. Trends Food Sci Technol 129:581\u2013590. https:\/\/doi.org\/10.1016\/j.tifs.2022.10.019","journal-title":"Trends Food Sci Technol"},{"key":"11246_CR121","doi-asserted-by":"publisher","first-page":"0911675717","DOI":"10.1101\/2025.09.11.675717","volume":"2025","author":"S Soriano","year":"2025","unstructured":"Soriano S, Marshall A, Holcomb M, Flinn H, Burke M, Kara G, Scalzo P, Villapol S (2025) Sex-specific effects of fecal microbiota transplantation on TBI-exacerbated Alzheimer\u2019s pathology in mice. bioRxiv: Preprint Serv Biology 2025:0911675717. https:\/\/doi.org\/10.1101\/2025.09.11.675717","journal-title":"bioRxiv: Preprint Serv Biology"},{"issue":"2","key":"11246_CR122","doi-asserted-by":"publisher","first-page":"e1900636","DOI":"10.1002\/mnfr.201900636","volume":"64","author":"J Sun","year":"2020","unstructured":"Sun J, Xu J, Yang B, Chen K, Kong Y, Fang N, Gong T, Wang F, Ling Z, Liu J (2020) Effect of Clostridium butyricum against Microglia-Mediated Neuroinflammation in Alzheimer\u2019s Disease via Regulating Gut Microbiota and Metabolites Butyrate. Mol Nutr Food Res 64(2):e1900636. https:\/\/doi.org\/10.1002\/mnfr.201900636","journal-title":"Mol Nutr Food Res"},{"key":"11246_CR123","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.ijbiomac.2020.07.208","volume":"164","author":"Q Sun","year":"2020","unstructured":"Sun Q, Cheng L, Zeng X, Zhang X, Wu Z, Weng P (2020) The modulatory effect of plant polysaccharides on gut flora and the implication for neurodegenerative diseases from the perspective of the microbiota-gut-brain axis. Int J Biol Macromol 164:1484\u20131492. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.208","journal-title":"Int J Biol Macromol"},{"issue":"44","key":"11246_CR124","doi-asserted-by":"publisher","first-page":"27509","DOI":"10.1073\/pnas.1921223117","volume":"117","author":"S Sun","year":"2020","unstructured":"Sun S, Luo L, Liang W, Yin Q, Guo J, Rush AM, Lv Z, Liang Q, Fischbach MA, Sonnenburg JL, Dodd D, Davis MM, Wang F (2020) Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade. Proc Natl Acad Sci USA 117(44):27509\u201327515. https:\/\/doi.org\/10.1073\/pnas.1921223117","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"11246_CR125","doi-asserted-by":"publisher","first-page":"3970","DOI":"10.3390\/ijms24043970","volume":"24","author":"R Suzuki","year":"2023","unstructured":"Suzuki R, Takahashi H, Yoshida C, Hidaka M, Ogawa T, Futai E (2023) Specific mutations near the amyloid precursor protein cleavage site increase \u03b3-Secretase sensitivity and modulate Amyloid-\u03b2 production. Int J Mol Sci 24(4):3970. https:\/\/doi.org\/10.3390\/ijms24043970","journal-title":"Int J Mol Sci"},{"issue":"30","key":"11246_CR126","doi-asserted-by":"publisher","first-page":"e43542","DOI":"10.1097\/MD.0000000000043542","volume":"104","author":"OP-C Ugwu","year":"2025","unstructured":"Ugwu OP-C, Okon MB, Alum EU, Ugwu CN, Anyanwu EG, Mariam B, Ogenyi FC, Eze VHU, Anyanwu CN, Ezeonwumelu JOC, Egba SI, Uti DE, Onohuean H, Aja PM, Ugwu MN (2025) Unveiling the therapeutic potential of the gut microbiota-brain axis: Novel insights and clinical applications in neurological disorders. Medicine 104(30):e43542. https:\/\/doi.org\/10.1097\/MD.0000000000043542","journal-title":"Medicine"},{"key":"11246_CR127","doi-asserted-by":"publisher","first-page":"102466","DOI":"10.1016\/j.arr.2024.102466","volume":"100","author":"S Vashishth","year":"2024","unstructured":"Vashishth S, Ambasta RK, Kumar P (2024) Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder. Ageing Res Rev 100:102466. https:\/\/doi.org\/10.1016\/j.arr.2024.102466","journal-title":"Ageing Res Rev"},{"issue":"5","key":"11246_CR128","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1093\/brain\/awx056","volume":"140","author":"H Vicente Miranda","year":"2017","unstructured":"Vicente Miranda H, Szego \u00c9M, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Sim\u00f5es T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Outeiro TF (2017) Glycation potentiates \u03b1-synuclein-associated neurodegeneration in synucleinopathies. Brain 140(5):1399\u20131419. https:\/\/doi.org\/10.1093\/brain\/awx056","journal-title":"Brain"},{"issue":"11","key":"11246_CR129","doi-asserted-by":"publisher","first-page":"4766","DOI":"10.1073\/pnas.91.11.4766","volume":"91","author":"MP Vitek","year":"1994","unstructured":"Vitek MP, Bhattacharya K, Glendening JM, Stopa E, Vlassara H, Bucala R, Manogue K, Cerami A (1994) Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci USA 91(11):4766\u20134770. https:\/\/doi.org\/10.1073\/pnas.91.11.4766","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"11246_CR130","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13195-025-01880-x","volume":"18","author":"B Wang","year":"2026","unstructured":"Wang B, Pan M, Yang L, Xu J, Ye C, Li Y, Gong Q, Liu C, Li L, Qin J, Ren D, Zhao C, Liang C (2026) Akkermansia muciniphila reduces neuroinflammation and A\u03b2 deposition via tryptophan metabolism in the APP\/PS1 mouse model of Alzheimer\u2019s disease. Alzheimer\u2019s Res Therapy 18(1):41. https:\/\/doi.org\/10.1186\/s13195-025-01880-x","journal-title":"Alzheimer\u2019s Res Therapy"},{"issue":"5","key":"11246_CR131","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.cell.2020.09.054","volume":"183","author":"J Wang","year":"2020","unstructured":"Wang J, Jelcic I, M\u00fchlenbruch L, Haunerdinger V, Toussaint NC, Zhao Y, Cruciani C, Faigle W, Naghavian R, Foege M, Binder TMC, Eiermann T, Opitz L, Fuentes-Font L, Reynolds R, Kwok WW, Nguyen JT, Lee J-H, Lutterotti A, Martin R (2020) HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell 183(5):1264\u20131281e20. https:\/\/doi.org\/10.1016\/j.cell.2020.09.054","journal-title":"Cell"},{"key":"11246_CR132","doi-asserted-by":"publisher","first-page":"106086","DOI":"10.1016\/j.bbi.2025.106086","volume":"130","author":"J Wang","year":"2025","unstructured":"Wang J, Xue L, Zhang M, Shen P, Zhao W, Tong Q, Wu S, Dai W, Yang X, Wang H (2025) Colonoscopic fecal microbiota transplantation for Mild-to-Moderate Parkinson\u2019s Disease: A randomized controlled trial. Brain Behav Immun 130:106086. https:\/\/doi.org\/10.1016\/j.bbi.2025.106086","journal-title":"Brain Behav Immun"},{"key":"11246_CR133","doi-asserted-by":"publisher","first-page":"1757551","DOI":"10.3389\/fmicb.2026.1757551","volume":"17","author":"J Wang","year":"2026","unstructured":"Wang J, Zhang Y, Wu Q, Zhong Y, Xu Z, Yang J (2026) Interactions of bile acids and gut microbiota modulate neurological health: A comprehensive review on mechanisms and therapeutic potential of dietary phytochemicals. Front Microbiol 17:1757551. https:\/\/doi.org\/10.3389\/fmicb.2026.1757551","journal-title":"Front Microbiol"},{"issue":"1","key":"11246_CR134","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","volume":"4","author":"S Weidinger","year":"2018","unstructured":"Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD (2018) Atopic dermatitis. Nat Reviews Disease Primers 4(1):1. https:\/\/doi.org\/10.1038\/s41572-018-0001-z","journal-title":"Nat Reviews Disease Primers"},{"issue":"5","key":"11246_CR135","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","volume":"72","author":"MD Weingarten","year":"1975","unstructured":"Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci USA 72(5):1858\u20131862. https:\/\/doi.org\/10.1073\/pnas.72.5.1858","journal-title":"Proc Natl Acad Sci USA"},{"key":"11246_CR136","doi-asserted-by":"publisher","first-page":"102667","DOI":"10.1016\/j.arr.2025.102667","volume":"104","author":"P Wen","year":"2025","unstructured":"Wen P, Sun Z, Gou F, Wang J, Fan Q, Zhao D, Yang L (2025) Oxidative stress and mitochondrial impairment: Key drivers in neurodegenerative disorders. Ageing Res Rev 104:102667. https:\/\/doi.org\/10.1016\/j.arr.2025.102667","journal-title":"Ageing Res Rev"},{"issue":"4","key":"11246_CR137","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","volume":"186","author":"DM Wilson","year":"2023","unstructured":"Wilson DM, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I (2023) Hallmarks of neurodegenerative diseases. Cell 186(4):693\u2013714. https:\/\/doi.org\/10.1016\/j.cell.2022.12.032","journal-title":"Cell"},{"issue":"1","key":"11246_CR138","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s13578-023-01053-z","volume":"13","author":"C Xing","year":"2023","unstructured":"Xing C, Huang X, Wang D, Yu D, Hou S, Cui H, Song L (2023) Roles of bile acids signaling in neuromodulation under physiological and pathological conditions. Cell Bioscience 13(1):106. https:\/\/doi.org\/10.1186\/s13578-023-01053-z","journal-title":"Cell Bioscience"},{"issue":"1","key":"11246_CR139","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.cmet.2024.10.006","volume":"37","author":"H Xu, Huang","year":"2025","unstructured":"Xu, Huang H, Cao J, Liu S, Bian X, Zhang Y, Xiao F, Xie Y, Wang W, Zhang C (2025) Microbiota-derived lysophosphatidylcholine alleviates Alzheimer\u2019s disease pathology via suppressing ferroptosis. Cell Metabol 37(1):169\u2013186e9. https:\/\/doi.org\/10.1016\/j.cmet.2024.10.006","journal-title":"Cell Metabol"},{"key":"11246_CR140","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.ijbiomac.2020.05.180","volume":"161","author":"M Xu","year":"2020","unstructured":"Xu M, Mo X, Huang H, Chen X, Liu H, Peng Z, Chen L, Rong S, Yang W, Xu S, Liu L (2020) Yeast \u03b2-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in A\u03b21\u201342-induced AD-like mice. Int J Biol Macromol 161:258\u2013270. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.05.180","journal-title":"Int J Biol Macromol"},{"key":"11246_CR141","doi-asserted-by":"publisher","unstructured":"Xu T, Roy SP, Hadia R, Annu A, Bhowmik S, Panchal A (2026) The gut\u2013brain axis in pharmacology: Microbiome-driven modulation of CNS drugs and neuropsychiatric outcomes. Front Pharmacol 17. https:\/\/doi.org\/10.3389\/fphar.2026.1826681","DOI":"10.3389\/fphar.2026.1826681"},{"key":"11246_CR142","doi-asserted-by":"publisher","first-page":"114660","DOI":"10.1016\/j.ecoenv.2023.114660","volume":"253","author":"Y Xu","year":"2023","unstructured":"Xu Y, Wei S, Zhu L, Huang C, Yang T, Wang S, Zhang Y, Duan Y, Li X, Wang Z, Pan W (2023) Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons. Ecotoxicol Environ Saf 253:114660. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114660","journal-title":"Ecotoxicol Environ Saf"},{"issue":"35","key":"11246_CR143","doi-asserted-by":"publisher","first-page":"e22035","DOI":"10.1097\/MD.0000000000022035","volume":"99","author":"L-J Xue","year":"2020","unstructured":"Xue L-J, Yang X-Z, Tong Q, Shen P, Ma S-J, Wu S-N, Zheng J-L, Wang H-G (2020) Fecal microbiota transplantation therapy for Parkinson\u2019s disease: A preliminary study. Medicine 99(35):e22035. https:\/\/doi.org\/10.1097\/MD.0000000000022035","journal-title":"Medicine"},{"key":"11246_CR144","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.crfs.2022.06.003","volume":"5","author":"M Yamamoto","year":"2022","unstructured":"Yamamoto M, Handa N, Nakamura A, Takahashi H, Kuda T (2022) In vitro antioxidant, anti-glycation, and bile acid-lowering capacity of peanut milk fermented with Lactiplantibacillus plantarum Kinko-SU4. Curr Res Food Sci 5:992\u2013997. https:\/\/doi.org\/10.1016\/j.crfs.2022.06.003","journal-title":"Curr Res Food Sci"},{"issue":"5","key":"11246_CR145","doi-asserted-by":"publisher","first-page":"200","DOI":"10.5607\/en25022","volume":"34","author":"L Yan","year":"2025","unstructured":"Yan L, Zhou L, Liu H, Huang X, Li Y, Li X, Huang S (2025) G protein-coupled estrogen receptor activation exerts protective effects via modulating brain and Gut NLRP3 inflammasome in Parkinson\u2019s disease. Experimental Neurobiol 34(5):200\u2013213. https:\/\/doi.org\/10.5607\/en25022","journal-title":"Experimental Neurobiol"},{"issue":"7","key":"11246_CR146","doi-asserted-by":"publisher","first-page":"e70406","DOI":"10.1002\/alz.70406","volume":"21","author":"C Yang","year":"2025","unstructured":"Yang C, Sun J, Li L, Zheng J, Wang C, Zhao Y, Yun D, Jia M, Wu Z, Liang H, Li W, Hu T, Guo R, Xiao L, Zou Y, Liu Z (2025) Synbiotics of Lactobacillus suilingensis and inulin alleviates cognitive impairment via regulating gut microbiota indole-3-lactic acid metabolism in female AD mice. Alzheimer\u2019s Dementia: J Alzheimer\u2019s Association 21(7):e70406. https:\/\/doi.org\/10.1002\/alz.70406","journal-title":"Alzheimer\u2019s Dementia: J Alzheimer\u2019s Association"},{"issue":"8","key":"11246_CR147","doi-asserted-by":"publisher","first-page":"e656","DOI":"10.1002\/mco2.656","volume":"5","author":"M You","year":"2024","unstructured":"You M, Chen N, Yang Y, Cheng L, He H, Cai Y, Liu Y, Liu H, Hong G (2024) The gut microbiota-brain axis in neurological disorders. MedComm 5(8):e656. https:\/\/doi.org\/10.1002\/mco2.656","journal-title":"MedComm"},{"issue":"9","key":"11246_CR148","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1007\/s00213-024-06606-9","volume":"241","author":"A Zali","year":"2024","unstructured":"Zali A, Hajyani S, Salari M, Tajabadi-Ebrahimi M, Mortazavian AM, Pakpour B (2024) Co-administration of probiotics and vitamin D reduced disease severity and complications in patients with Parkinson\u2019s disease: A randomized controlled clinical trial. Psychopharmacology 241(9):1905\u20131914. https:\/\/doi.org\/10.1007\/s00213-024-06606-9","journal-title":"Psychopharmacology"},{"issue":"22","key":"11246_CR149","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1212\/WNL.0000000000003391","volume":"87","author":"X Zhan","year":"2016","unstructured":"Zhan X, Stamova B, Jin L-W, DeCarli C, Phinney B, Sharp FR (2016) Gram-negative bacterial molecules associate with Alzheimer disease pathology. Neurology 87(22):2324\u20132332. https:\/\/doi.org\/10.1212\/WNL.0000000000003391","journal-title":"Neurology"},{"issue":"14","key":"11246_CR150","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.3390\/nu17142312","volume":"17","author":"G Zhang","year":"2025","unstructured":"Zhang G, Dou Y, Xie H, Pu D, Wang L, Wang R, Han X (2025) Sea cucumber egg oligopeptides ameliorate cognitive impairments and pathology of Alzheimer\u2019s disease through regulating HDAC3 and BDNF\/NT3 via the microbiota\u2013gut\u2013brain axis. Nutrients 17(14):2312. https:\/\/doi.org\/10.3390\/nu17142312","journal-title":"Nutrients"},{"issue":"5","key":"11246_CR151","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3892\/ijmm.2025.5633","volume":"56","author":"H Zhang","year":"2025","unstructured":"Zhang H, Luan J, He L, Pan X, Zhang H, Li Y, Li H (2025) Role of the gut-brain axis in neurological diseases: Molecular connections and therapeutic implications (Review). Int J Mol Med 56(5):192. https:\/\/doi.org\/10.3892\/ijmm.2025.5633","journal-title":"Int J Mol Med"},{"issue":"1","key":"11246_CR152","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41392-026-02604-9","volume":"11","author":"R Zhang","year":"2026","unstructured":"Zhang R, Feng R, Wang J, Chen Y, Liu H, Zhu Q, Tian H, Qin C, Teng J, Tang B, Wu M, Zeng J, Wu E, Ding X, Wang X (2026) Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-na\u00efve Parkinson\u2019s disease: A randomized phase 2 trial. Signal Transduct Target Therapy 11(1):94. https:\/\/doi.org\/10.1038\/s41392-026-02604-9","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"11246_CR153","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1186\/s12967-025-07209-4","volume":"23","author":"W Zhang","year":"2025","unstructured":"Zhang W, Song J, Zhong F, Yu W, Qin Z, Yang Z, Liu J, Wang X, Chen L, L\u00fc W, Xing D, Liu J, Huang C, Wu J, Liu X, Yu W, L\u00fc Y (2025) Computerized cognitive training enhances cognitive function in Alzheimer\u2019s disease by downregulating Ruminococcus-TMAO pathway. J Translational Med 23(1):1173. https:\/\/doi.org\/10.1186\/s12967-025-07209-4","journal-title":"J Translational Med"},{"key":"11246_CR154","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jare.2025.04.025","volume":"80","author":"Y Zhao","year":"2026","unstructured":"Zhao Y, Zhao W, Chai X, Sun P, Huang J, Guo X, Zhang L, Ren D, Yi C, Zhu X, Zhao S (2026) Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer\u2019s disease. J Adv Res 80:219\u2013237. https:\/\/doi.org\/10.1016\/j.jare.2025.04.025","journal-title":"J Adv Res"},{"issue":"19","key":"11246_CR155","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1016\/j.cell.2022.08.021","volume":"185","author":"X Zhou","year":"2022","unstructured":"Zhou X, Baumann R, Gao X, Mendoza M, Singh S, Katz Sand I, Xia Z, Cox LM, Chitnis T, Yoon H, Moles L, Caillier SJ, Santaniello A, Ackermann G, Harroud A, Lincoln R, Gomez R, Gonz\u00e1lez Pe\u00f1a A, Digga E, Baranzini SE (2022a) Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell 185(19):3467\u20133486e16. https:\/\/doi.org\/10.1016\/j.cell.2022.08.021","journal-title":"Cell"},{"issue":"19","key":"11246_CR156","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1016\/j.cell.2022.08.021","volume":"185","author":"X Zhou","year":"2022","unstructured":"Zhou X, Baumann R, Gao X, Mendoza M, Singh S, Katz Sand I, Xia Z, Cox LM, Chitnis T, Yoon H, Moles L, Caillier SJ, Santaniello A, Ackermann G, Harroud A, Lincoln R, Gomez R, Gonz\u00e1lez Pe\u00f1a A, Digga E, Baranzini SE (2022b) Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell 185(19):3467\u20133486e16. https:\/\/doi.org\/10.1016\/j.cell.2022.08.021","journal-title":"Cell"},{"issue":"1","key":"11246_CR157","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41575-022-00663-1","volume":"20","author":"S Zundler","year":"2023","unstructured":"Zundler S, G\u00fcnther C, Kremer AE, Zaiss MM, Rothhammer V, Neurath MF (2023) Gut immune cell trafficking: Inter-organ communication and immune-mediated inflammation. Nat Rev Gastroenterol Hepatol 20(1):50\u201364. https:\/\/doi.org\/10.1038\/s41575-022-00663-1","journal-title":"Nat Rev Gastroenterol Hepatol"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11246-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-026-11246-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11246-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:04:43Z","timestamp":1791673483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12602-026-11246-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":157,"alternative-id":["11246"],"URL":"https:\/\/doi.org\/10.1007\/s12602-026-11246-w","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"assertion":[{"value":"13 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}