{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:46:19Z","timestamp":1792439179513,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key R&D Program of Gansu Province, China","award":["23ZDKA0007"],"award-info":[{"award-number":["23ZDKA0007"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2025-26"],"award-info":[{"award-number":["lzujbky-2025-26"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Probiotics &amp; Antimicro. Prot."],"DOI":"10.1007\/s12602-026-11255-9","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:08:40Z","timestamp":1792393720000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactiplantibacillus plantarum Strains LP5 and BX62 Alleviate Liver Injury of NAFLD in Rats via Regulating Hepatic Cholesterol Metabolism and Antioxidant Signaling Pathways"],"prefix":"10.1007","author":[{"given":"Mengya","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaorui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1062-2298","authenticated-orcid":false,"given":"Zitong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"11255_CR1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/BF02205240","volume":"5","author":"KD Rainsford","year":"1975","unstructured":"Rainsford KD (1975) The biochemical pathology of aspirin-induced gastric damage. Agents Actions 5:326\u2013344. https:\/\/doi.org\/10.1007\/BF02205240","journal-title":"Agents Actions"},{"key":"11255_CR2","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","volume":"55","author":"J Ludwig","year":"1980","unstructured":"Ludwig J, Viggiano TR, McGill DB et al (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55:434\u2013438","journal-title":"Mayo Clin Proc"},{"key":"11255_CR3","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1002\/hep.29085","volume":"65","author":"PS Dulai","year":"2017","unstructured":"Dulai PS, Singh S, Patel J et al (2017) Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis. Hepatology 65:1557\u20131565. https:\/\/doi.org\/10.1002\/hep.29085","journal-title":"Hepatology"},{"key":"11255_CR4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/cld.1061","volume":"17","author":"S Cheemerla","year":"2021","unstructured":"Cheemerla S, M Balakrishnan (2021) Global Epidemiology of Chronic Liver Disease. Clin Liver Disease 17:365\u2013370. https:\/\/doi.org\/10.1002\/cld.1061","journal-title":"Clin Liver Disease"},{"key":"11255_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.7861\/clinmedicine.7-2-119","volume":"7","author":"S Whalley","year":"2007","unstructured":"Whalley S, Puvanachandra P, Desai A et al (2007) Hepatology outpatient service provision in secondary care: a study of liver disease incidence and resource costs. Clin Med (Lond) 7:119\u2013124. https:\/\/doi.org\/10.7861\/clinmedicine.7-2-119","journal-title":"Clin Med (Lond)"},{"key":"11255_CR6","unstructured":"(N.d (2026) Global burden of disease 2023: findings from the GBD 2023 study | institute for health metrics and evaluation,. https:\/\/www.healthdata.org\/research-analysis\/library\/global-burden-disease-2023-findings-gbd-2023-study"},{"key":"11255_CR7","first-page":"9","volume":"13","author":"P Paschos","year":"2009","unstructured":"Paschos P, Paletas K (2009) Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia 13:9\u201319","journal-title":"Hippokratia"},{"key":"11255_CR8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.cld.2017.08.010","volume":"22","author":"D Kim","year":"2018","unstructured":"Kim D, Touros A, Kim WR (2018) Nonalcoholic Fatty Liver Disease and Metabolic Syndrome. Clin Liver Dis 22:133\u2013140. https:\/\/doi.org\/10.1016\/j.cld.2017.08.010","journal-title":"Clin Liver Dis"},{"key":"11255_CR9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","volume":"68","author":"F Marra","year":"2018","unstructured":"Marra F, Svegliati-Baroni G (2018) Lipotoxicity and the gut-liver axis in NASH pathogenesis. J Hepatol 68:280\u2013295. https:\/\/doi.org\/10.1016\/j.jhep.2017.11.014","journal-title":"J Hepatol"},{"key":"11255_CR10","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.29367","volume":"67","author":"N Chalasani","year":"2018","unstructured":"Chalasani N, Younossi Z, Lavine JE et al (2018) The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology 67:328\u2013357. https:\/\/doi.org\/10.1002\/hep.29367","journal-title":"Hepatology"},{"key":"11255_CR11","doi-asserted-by":"publisher","first-page":"110490","DOI":"10.1016\/j.foodres.2021.110490","volume":"147","author":"C Tang","year":"2021","unstructured":"Tang C, Kong L, Shan M et al (2021) Protective and ameliorating effects of probiotics against diet-induced obesity: A review. Food Res Int 147:110490. https:\/\/doi.org\/10.1016\/j.foodres.2021.110490","journal-title":"Food Res Int"},{"key":"11255_CR12","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1039\/C4FO00549J","volume":"5","author":"C Li","year":"2014","unstructured":"Li C, Nie S-P, Zhu K-X et al (2014) Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease. Food Funct 5:3216\u20133223. https:\/\/doi.org\/10.1039\/C4FO00549J","journal-title":"Food Funct"},{"key":"11255_CR13","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.1007\/s10620-015-3770-1","volume":"60","author":"W Sohn","year":"2015","unstructured":"Sohn W, Jun DW, Lee KN et al (2015) Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis. Dig Dis Sci 60:3340\u20133350. https:\/\/doi.org\/10.1007\/s10620-015-3770-1","journal-title":"Dig Dis Sci"},{"key":"11255_CR14","doi-asserted-by":"publisher","first-page":"8342","DOI":"10.1039\/D0FO01939A","volume":"11","author":"Z Ding","year":"2020","unstructured":"Ding Z, Hanif A, Li W et al (2020) Influence of a cholesterol-lowering strain Lactobacillus plantarum LP5 isolated from traditional fermented yak milk on gut bacterial microbiota and metabolome of rats fed with a high-fat diet. Food Funct 11:8342\u20138353. https:\/\/doi.org\/10.1039\/D0FO01939A","journal-title":"Food Funct"},{"key":"11255_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2024.100915","author":"Q Qin","year":"2024","unstructured":"Qin Q, Hu G, Zhou X et al (2024) Therapeutic potential of the probiotic Lactiplantibacillus plantarum BX 62 and its postbiotics in alleviating rheumatoid arthritis in mice. Curr Res Food Sci. https:\/\/doi.org\/10.1016\/j.crfs.2024.100915. 9,100915","journal-title":"Curr Res Food Sci"},{"key":"11255_CR16","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.cgh.2012.08.012","volume":"10","author":"A Fasano","year":"2012","unstructured":"Fasano A (2012) Intestinal Permeability and Its Regulation by Zonulin: Diagnostic and Therapeutic Implications. Clin Gastroenterol Hepatol 10:1096\u20131100. https:\/\/doi.org\/10.1016\/j.cgh.2012.08.012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"11255_CR17","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cld.2009.07.009","volume":"13","author":"K Cusi","year":"2009","unstructured":"Cusi K (2009) Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis. Clin Liver Dis 13:545\u2013563. https:\/\/doi.org\/10.1016\/j.cld.2009.07.009","journal-title":"Clin Liver Dis"},{"key":"11255_CR18","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nature09646","volume":"469","author":"S Fukuda","year":"2011","unstructured":"Fukuda S, Toh H, Hase K et al (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469:543\u2013547. https:\/\/doi.org\/10.1038\/nature09646","journal-title":"Nature"},{"key":"11255_CR19","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1113\/jphysiol.2011.224568","volume":"590","author":"NA Hering","year":"2012","unstructured":"Hering NA, Fromm M, Schulzke J-D (2012) Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J Physiol 590:1035\u20131044. https:\/\/doi.org\/10.1113\/jphysiol.2011.224568","journal-title":"J Physiol"},{"key":"11255_CR20","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.nutres.2015.12.001","volume":"36","author":"S-M Lim","year":"2016","unstructured":"Lim S-M, Jeong J-J, Woo KH et al (2016) Lactobacillus sakei OK67 ameliorates high-fat diet\u2013induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression. Nutr Res 36:337\u2013348. https:\/\/doi.org\/10.1016\/j.nutres.2015.12.001","journal-title":"Nutr Res"},{"key":"11255_CR21","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1039\/C9FO03003D","volume":"11","author":"M Chen","year":"2020","unstructured":"Chen M, Guo WL, Li QY (2020) The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet. Food Funct 11:3316\u20133331. https:\/\/doi.org\/10.1039\/C9FO03003D","journal-title":"Food Funct"},{"key":"11255_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"Z Younossi","year":"2018","unstructured":"Younossi Z, Anstee QM, Marietti M (2018) Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 15:11\u201320. https:\/\/doi.org\/10.1038\/nrgastro.2017.109","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"11255_CR23","doi-asserted-by":"publisher","first-page":"8342","DOI":"10.1039\/D0FO01939A","volume":"11","author":"Z Ding","year":"2020","unstructured":"Ding Z, Hanif A, Li W et al (2020) Influence of a cholesterol-lowering strain Lactobacillus plantarum LP5 isolated from traditional fermented yak milk on gut bacterial microbiota and metabolome of rats fed with a high-fat diet. Food Funct 11:8342\u20138353. https:\/\/doi.org\/10.1039\/D0FO01939A","journal-title":"Food Funct"},{"key":"11255_CR24","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1056\/NEJM199205213262107","volume":"326","author":"JE Manson","year":"1992","unstructured":"Manson JE, Tosteson H, Ridker PM et al (1992) The primary prevention of myocardial infarction, N. Engl. J Med 326:1406\u20131416. https:\/\/doi.org\/10.1056\/NEJM199205213262107","journal-title":"J Med"},{"key":"11255_CR25","doi-asserted-by":"publisher","first-page":"20779","DOI":"10.1021\/acs.jafc.5c03853","volume":"73","author":"X Zhang","year":"2025","unstructured":"Zhang X, Zhao S, Cai S et al (2025) Screening Cholesterol-Lowering Lactiplantibacillus plantarum through In Vitro Experiments, Whole Genomics Analysis, and In Silico Approaches: From the Perspective of Bile Salt Hydrolase and Cholesterol. J Agric Food Chem 73:20779\u201320791. https:\/\/doi.org\/10.1021\/acs.jafc.5c03853","journal-title":"J Agric Food Chem"},{"key":"11255_CR26","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1039\/c7fo01108c","volume":"8","author":"H Ye","year":"2017","unstructured":"Ye H, Li Q, Zhang Z et al (2017) Effect of a novel potential probiotic Lactobacillus paracasei Jlus66 isolated from fermented milk on nonalcoholic fatty liver in rats. Food Funct 8:4539\u20134546. https:\/\/doi.org\/10.1039\/c7fo01108c","journal-title":"Food Funct"},{"key":"11255_CR27","doi-asserted-by":"publisher","first-page":"153728","DOI":"10.1016\/j.phymed.2021.153728","volume":"95","author":"X Li","year":"2022","unstructured":"Li X, Chu L, Liu S et al (2022) Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice. Phytomedicine 95:153728. https:\/\/doi.org\/10.1016\/j.phymed.2021.153728","journal-title":"Phytomedicine"},{"key":"11255_CR28","doi-asserted-by":"publisher","first-page":"690817","DOI":"10.3389\/fimmu.2021.690817","volume":"12","author":"S Papoutsopoulou","year":"2021","unstructured":"Papoutsopoulou S, Pollock L, Walker C et al (2021) Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals. Front Immunol 12:690817. https:\/\/doi.org\/10.3389\/fimmu.2021.690817","journal-title":"Front Immunol"},{"key":"11255_CR29","doi-asserted-by":"publisher","first-page":"0222339","DOI":"10.1371\/journal.pone.0222339","volume":"14","author":"X Liu","year":"2019","unstructured":"Liu X, Wang Y, Yi C et al (2019) Protective effect of Lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae. PLoS ONE 14:0222339. https:\/\/doi.org\/10.1371\/journal.pone.0222339","journal-title":"PLoS ONE"},{"key":"11255_CR30","doi-asserted-by":"publisher","first-page":"101138","DOI":"10.1016\/j.crfs.2025.101138","volume":"11","author":"J Lu","year":"2025","unstructured":"Lu J, Dong X, Gao Z et al (2025) Probiotics as a therapeutic strategy for metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis. Curr Res Food Sci 11:101138. https:\/\/doi.org\/10.1016\/j.crfs.2025.101138","journal-title":"Curr Res Food Sci"},{"key":"11255_CR31","doi-asserted-by":"publisher","first-page":"9250211","DOI":"10.26599\/FSHW.2024.9250211","volume":"14","author":"W Fang","year":"2025","unstructured":"Fang W, Zhou F, Wang K et al (2025) Protective effect of Fu brick tea on high-fat diet-induced metabolic syndrome: relevant to protecting the intestinal barrier and regulating the gut microbiota. Food Sci Hum Wellness 14:9250211. https:\/\/doi.org\/10.26599\/FSHW.2024.9250211","journal-title":"Food Sci Hum Wellness"},{"key":"11255_CR32","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/apt.15035","volume":"49","author":"C Caussy","year":"2019","unstructured":"Caussy C, Hsu C, Singh S et al (2019) Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Aliment Pharmacol Ther 49:183\u2013193. https:\/\/doi.org\/10.1111\/apt.15035","journal-title":"Aliment Pharmacol Ther"},{"key":"11255_CR33","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41575-021-00502-9","volume":"18","author":"M Masoodi","year":"2021","unstructured":"Masoodi M, Gastaldelli A, Hy\u00f6tyl\u00e4inen T et al (2021) Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. Nat Rev Gastroenterol Hepatol 18:835\u2013856. https:\/\/doi.org\/10.1038\/s41575-021-00502-9","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"11255_CR34","doi-asserted-by":"publisher","first-page":"154457","DOI":"10.1016\/j.metabol.2020.154457","volume":"116","author":"N Nimer","year":"2021","unstructured":"Nimer N, Choucair I, Wang Z et al (2021) Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression. Metabolism 116:154457. https:\/\/doi.org\/10.1016\/j.metabol.2020.154457","journal-title":"Metabolism"},{"key":"11255_CR35","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.cmi.2018.03.011","volume":"24","author":"J Rello","year":"2018","unstructured":"Rello J, Engelen TSR, Alp E (2018) Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases. Clin Microbiol Infect 24:1264\u20131272. https:\/\/doi.org\/10.1016\/j.cmi.2018.03.011","journal-title":"Clin Microbiol Infect"},{"key":"11255_CR36","doi-asserted-by":"publisher","first-page":"e476","DOI":"10.1002\/mco2.476","volume":"5","author":"J Guo","year":"2024","unstructured":"Guo J, Chen S, Zhang Y et al (2024) Cholesterol metabolism: physiological regulation and diseases. MedComm 5:e476. https:\/\/doi.org\/10.1002\/mco2.476","journal-title":"MedComm"},{"key":"11255_CR37","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jhep.2003.11.006","volume":"40","author":"JYL Chiang","year":"2004","unstructured":"Chiang JYL (2004) Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J Hepatol 40:539\u2013551. https:\/\/doi.org\/10.1016\/j.jhep.2003.11.006","journal-title":"J Hepatol"},{"key":"11255_CR38","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.jcmgh.2016.08.004","volume":"2","author":"SJ Keely","year":"2016","unstructured":"Keely SJ, Walters JRF (2016) The Farnesoid X Receptor: Good for BAD. Cell Mol Gastroenterol Hepatol 2:725\u2013732. https:\/\/doi.org\/10.1016\/j.jcmgh.2016.08.004","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"11255_CR39","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.cmet.2012.04.004","volume":"15","author":"HK Min","year":"2012","unstructured":"Min HK, Kapoor A, Fuchs M (2012) Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab 15:665\u2013674. https:\/\/doi.org\/10.1016\/j.cmet.2012.04.004","journal-title":"Cell Metab"},{"key":"11255_CR40","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0005-2760(95)00116-t","volume":"1258","author":"DG Fast","year":"1995","unstructured":"Fast DG, DE Vance (1995) Nascent VLDL phospholipid composition is altered when phosphatidylcholine biosynthesis is inhibited: evidence for a novel mechanism that regulates VLDL secretion. Biochim Biophys Acta 1258:159\u2013168. https:\/\/doi.org\/10.1016\/0005-2760(95)00116-t","journal-title":"Biochim Biophys Acta"},{"key":"11255_CR41","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1161\/ATVBAHA.109.188672","volume":"29","author":"Y Zhao","year":"2009","unstructured":"Zhao Y, Su B, Jacobs RL et al (2009) Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol 29:1349\u20131355. https:\/\/doi.org\/10.1161\/ATVBAHA.109.188672","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"11255_CR42","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.3945\/jn.110.124917","volume":"140","author":"KE Christensen","year":"2010","unstructured":"Christensen KE, Wu Q, Wang X et al (2010) Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. J Nutr 140:1736\u20131741. https:\/\/doi.org\/10.3945\/jn.110.124917","journal-title":"J Nutr"},{"key":"11255_CR43","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/poh2.70043","volume":"5","author":"R Wang","year":"2026","unstructured":"Wang R, Liu Z, Lin J et al (2026) Uric acid in metabolic dysfunction-associated steatotic liver disease. Portal Hypertens Cirrhosis 5:189\u2013206. https:\/\/doi.org\/10.1002\/poh2.70043","journal-title":"Portal Hypertens Cirrhosis"},{"key":"11255_CR44","doi-asserted-by":"publisher","unstructured":"Ryter SW (2022) Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders. https:\/\/doi.org\/10.3390\/antiox11030555. Antioxidants 11:","DOI":"10.3390\/antiox11030555"},{"key":"11255_CR45","doi-asserted-by":"publisher","first-page":"9250299","DOI":"10.26599\/FSHW.2024.9250299","volume":"14","author":"X Song","year":"2025","unstructured":"Song X, Li D, Sun J et al (2025) Dietary lycopene mitigates nonalcoholic steatohepatitis by regulating Nrf2\/PPAR\u03b1-dependent ferroptosis. Food Sci Hum Wellness 14:9250299. https:\/\/doi.org\/10.26599\/FSHW.2024.9250299","journal-title":"Food Sci Hum Wellness"},{"key":"11255_CR46","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2025.9250826","author":"X Liu","year":"2025","unstructured":"Liu X, He Y, Li X et al (2025) Cyanidin-3-O-Glucoside Ameliorated Hepatic Steatosis in AGEs-rich MCD Diet Induced NAFLD Mice Model via Inhibiting Endoplasmic Reticulum Stress, Food Sci. Hum Wellness. https:\/\/doi.org\/10.26599\/FSHW.2025.9250826","journal-title":"Hum Wellness"},{"key":"11255_CR47","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cell.2011.11.030","volume":"148","author":"Z Wang","year":"2012","unstructured":"Wang Z, Jiang H, Chen S et al (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148:228\u2013243. https:\/\/doi.org\/10.1016\/j.cell.2011.11.030","journal-title":"Cell"},{"key":"11255_CR48","doi-asserted-by":"publisher","unstructured":"Meng Z, Liu Q, Sun F et al (2019) Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK\/SREBP-1c signaling. Lipids Health Dis 18. https:\/\/doi.org\/10.1186\/s12944-019-1136-y","DOI":"10.1186\/s12944-019-1136-y"},{"key":"11255_CR49","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1039\/D0FO02501A","volume":"12","author":"A Sharma","year":"2021","unstructured":"Sharma A, Anand SK, Singh N et al (2021) Berbamine induced activation of the SIRT1\/LKB1\/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats. Food Funct 12:892\u2013909. https:\/\/doi.org\/10.1039\/D0FO02501A","journal-title":"Food Funct"},{"key":"11255_CR50","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s12602-023-10190-3","volume":"17","author":"P Li","year":"2025","unstructured":"Li P, He X, Feng E et al (2025) Lactobacillus acidophilus JYLA-126 ameliorates obesity-associated metabolic disorders by positively regulating the AMPK signaling pathway through the gut-liver axis. Probiotics Antimicrob Proteins 17:62\u201380. https:\/\/doi.org\/10.1007\/s12602-023-10190-3","journal-title":"Probiotics Antimicrob Proteins"},{"key":"11255_CR51","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1007\/s12602-025-10464-y","volume":"17","author":"Y Zhao","year":"2025","unstructured":"Zhao Y, Xie W, Duan J et al (2025) Probiotic limosilactobacillus reuteri DSM 17938 alleviates acute liver injury by activating the AMPK signaling via gut microbiota-derived propionate. Probiotics Antimicrob Proteins 17:5075\u20135094. https:\/\/doi.org\/10.1007\/s12602-025-10464-y","journal-title":"Probiotics Antimicrob Proteins"},{"key":"11255_CR52","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","volume":"13","author":"Y Li","year":"2011","unstructured":"Li Y, Xu S, Mihaylova MM (2011) AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice. Cell Metab 13:376\u2013388. https:\/\/doi.org\/10.1016\/j.cmet.2011.03.009","journal-title":"Cell Metab"},{"key":"11255_CR53","doi-asserted-by":"publisher","unstructured":"Diniz TA, Lima Junior EA, Teixeira AA (2021) Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-\u03b1 signaling in obese mice. Life Sci 266. https:\/\/doi.org\/10.1016\/j.lfs.2020.118868","DOI":"10.1016\/j.lfs.2020.118868"},{"key":"11255_CR54","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/j.fshw.2022.06.012","volume":"11","author":"P Ma","year":"2022","unstructured":"Ma P, Huang R, Ou Y (2022) A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice. Food Sci Hum Wellness 11:1544\u20131554. https:\/\/doi.org\/10.1016\/j.fshw.2022.06.012","journal-title":"Food Sci Hum Wellness"},{"key":"11255_CR55","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s10571-020-00955-7","volume":"42","author":"GS Ribas","year":"2022","unstructured":"Ribas GS, Vargas CR (2022) Evidence that Oxidative Disbalance and Mitochondrial Dysfunction are Involved in the Pathophysiology of Fatty Acid Oxidation Disorders. Cell Mol Neurobiol 42:521\u2013532. https:\/\/doi.org\/10.1007\/s10571-020-00955-7","journal-title":"Cell Mol Neurobiol"},{"key":"11255_CR56","doi-asserted-by":"publisher","unstructured":"Matzinger M, Fischhuber K, D P\u00f6l\u00f6ske et al (2020) AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes. Redox Biol 29. https:\/\/doi.org\/10.1016\/j.redox.2019.101393","DOI":"10.1016\/j.redox.2019.101393"}],"container-title":["Probiotics and Antimicrobial Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11255-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-026-11255-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12602-026-11255-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:02:45Z","timestamp":1792436565000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12602-026-11255-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":56,"alternative-id":["11255"],"URL":"https:\/\/doi.org\/10.1007\/s12602-026-11255-9","relation":{},"ISSN":["1867-1306","1867-1314"],"issn-type":[{"value":"1867-1306","type":"print"},{"value":"1867-1314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"8 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}