{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:23:30Z","timestamp":1791123810440,"version":"4.1.0"},"reference-count":7,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":5003,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1007\/s12603-010-0065-2","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T22:49:49Z","timestamp":1272667789000},"page":"294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pre-dementia Alzheimer's trials: Overview"],"prefix":"10.1016","volume":"14","author":[{"given":"P.S.","family":"Aisen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1007\/s12603-010-0065-2_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12603-010-0066-1","article-title":"The Potential and Limits for Clinical Trials for Early Alzheimer\u2019s Disease and Some Recommendations","volume":"14","author":"Schneider","year":"2010","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"10.1007\/s12603-010-0065-2_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12603-010-0067-0","article-title":"Evolving Early (Pre-Dementia) Alzheimer\u2019s Disease Trials: Suit the Outcomes to the Population and Study Design","volume":"14","author":"Doody","year":"2010","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"10.1007\/s12603-010-0065-2_bib3","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s12603-010-0068-z","article-title":"Clinical Trials for Early (Pre-Dementia) Alzheimer\u2019s Disease: A Case for Mild Cognitive Impairment","volume":"14","author":"Petersen","year":"2010","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"10.1007\/s12603-010-0065-2_bib4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s12603-010-0069-y","article-title":"Seeing with New Eyes: Finding a Path to Early Intervention Trials in Alzheimer\u2019s Disease","volume":"14","author":"Cedarbaum","year":"2010","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"10.1007\/s12603-010-0065-2_bib5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12603-010-0070-5","article-title":"Dose Ranging for Trials through Biomarkers of Drug Effects","volume":"14","author":"Potter","year":"2010","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"10.1007\/s12603-010-0065-2_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s12603-010-0071-4","article-title":"Study Design Considerations: Conducting Global Clinical Trials in Early Alzheimer\u2019s Disease","volume":"14","author":"Schindler","year":"2010","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"10.1007\/s12603-010-0065-2_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12603-010-0072-3","article-title":"Methodological issues in a cluster-randomized trial to prevent dementia by intensive vascular care","volume":"14","author":"Richard","year":"2010","journal-title":"J Nutr Health Aging"}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-010-0065-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12603-010-0065-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723019188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723019188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-010-0065-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:01:54Z","timestamp":1761138114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770723019188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":7,"aliases":["10.1007\/s12603-009-0222-7"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S1279770723019188"],"URL":"https:\/\/doi.org\/10.1007\/s12603-010-0065-2","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-dementia Alzheimer's trials: Overview","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-010-0065-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}